Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TAS2R14 P2RY12 ADGRG2 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 CCR8 TAS2R39 VN1R1 PTH1R GPR139 OR10D4P	8.34e-11	884	54	17	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TAS2R14 P2RY12 ADGRG2 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 CCR8 TAS2R39 VN1R1 EDA2R PTH1R GPR139 OR10D4P	7.53e-09	1353	54	18	GO:0004888
GeneOntologyMolecularFunction	protein-cysteine S-myristoyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	3.72e-07	6	54	3	GO:0019705
GeneOntologyMolecularFunction	protein-cysteine S-stearoyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	6.49e-07	7	54	3	GO:0140439
GeneOntologyMolecularFunction	myristoyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	3.04e-06	11	54	3	GO:0019107
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ATP11C ATP11A ANO10 ATP9A	1.09e-05	51	54	4	GO:0140303
GeneOntologyMolecularFunction	olfactory receptor activity	OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 OR10J4 OR10D4P	1.93e-05	431	54	8	GO:0004984
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	4.65e-05	26	54	3	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	4.65e-05	26	54	3	GO:0019707
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP11C ATP11A ATP9A	5.84e-05	28	54	3	GO:0140326
GeneOntologyMolecularFunction	phosphatidylserine flippase activity	ATP11C ATP11A	7.14e-05	5	54	2	GO:0140346
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	7.21e-05	30	54	3	GO:0016417
GeneOntologyMolecularFunction	taste receptor activity	TAS2R14 TAS1R1 TAS2R39	9.63e-05	33	54	3	GO:0008527
GeneOntologyMolecularFunction	palmitoyltransferase activity	ZDHHC2 ZDHHC20 ZDHHC15	1.36e-04	37	54	3	GO:0016409
GeneOntologyMolecularFunction	phosphatidylethanolamine flippase activity	ATP11C ATP11A	1.49e-04	7	54	2	GO:0090555
GeneOntologyMolecularFunction	aminophospholipid flippase activity	ATP11C ATP11A	1.49e-04	7	54	2	GO:0015247
GeneOntologyMolecularFunction	lipid transporter activity	ABCB11 ATP11C ATP11A ANO10 ATP9A	1.85e-04	196	54	5	GO:0005319
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP11C ATP11A	2.55e-04	9	54	2	GO:0090556
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ATP11C ATP11A	6.40e-04	14	54	2	GO:0140333
GeneOntologyMolecularFunction	floppase activity	ATP11C ATP11A	8.41e-04	16	54	2	GO:0140328
GeneOntologyMolecularFunction	flippase activity	ATP11C ATP11A	9.51e-04	17	54	2	GO:0140327
GeneOntologyMolecularFunction	phospholipid transporter activity	ATP11C ATP11A ANO10	1.06e-03	74	54	3	GO:0005548
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R14 TAS2R39	2.41e-03	27	54	2	GO:0033038
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ZDHHC2 ZDHHC20 ZDHHC15 CASD1	3.90e-03	238	54	4	GO:0016747
GeneOntologyMolecularFunction	odorant binding	OR5B12 OR10J3 OR10J4	4.92e-03	127	54	3	GO:0005549
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC17A5 ABCB11	5.77e-03	42	54	2	GO:0015144
GeneOntologyMolecularFunction	transporter activity	SLC30A7 SLC17A5 PIEZO1 ABCB11 SV2C ATP11C ATP11A ANO10 ATP9A	7.23e-03	1289	54	9	GO:0005215
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39 VN1R1 OR10D4P	1.67e-08	547	55	12	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39 OR10D4P	5.11e-08	485	55	11	GO:0050907
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	TAS2R14 P2RY12 ADGRG2 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 CCR8 TAS2R39 VN1R1 PTH1R GPR139 OR10D4P	6.83e-08	1395	55	17	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39 OR10D4P	1.12e-07	524	55	11	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39 OR10D4P	3.19e-07	582	55	11	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 PIEZO1 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39 OR10D4P	3.40e-07	722	55	12	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 OR10J4 OR10D4P	1.78e-05	432	55	8	GO:0050911
GeneOntologyBiologicalProcess	sensory perception	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39 VN1R1 OR10D4P	2.01e-05	1072	55	12	GO:0007600
GeneOntologyBiologicalProcess	sensory perception of smell	OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 OR10J4 OR10D4P	3.02e-05	465	55	8	GO:0007608
GeneOntologyBiologicalProcess	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	ZDHHC2 ZDHHC20 ZDHHC15	3.49e-05	24	55	3	GO:0018231
GeneOntologyBiologicalProcess	peptidyl-L-cysteine S-palmitoylation	ZDHHC2 ZDHHC20 ZDHHC15	3.49e-05	24	55	3	GO:0018230
GeneOntologyBiologicalProcess	protein palmitoylation	ZDHHC2 ZDHHC20 ZDHHC15	9.25e-05	33	55	3	GO:0018345
GeneOntologyBiologicalProcess	aminophospholipid translocation	ATP11C ATP11A	1.45e-04	7	55	2	GO:0140331
GeneOntologyBiologicalProcess	aminophospholipid transport	ATP11C ATP11A	2.48e-04	9	55	2	GO:0015917
GeneOntologyBiologicalProcess	peptidyl-cysteine modification	ZDHHC2 ZDHHC20 ZDHHC15	3.22e-04	50	55	3	GO:0018198
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	TAS2R14 TAS1R1 TAS2R39	3.22e-04	50	55	3	GO:0050912
GeneOntologyBiologicalProcess	phospholipid translocation	ATP11C ATP11A ATP9A	4.27e-04	55	55	3	GO:0045332
GeneOntologyBiologicalProcess	lipid translocation	ATP11C ATP11A ATP9A	5.51e-04	60	55	3	GO:0034204
GeneOntologyBiologicalProcess	positive regulation of integrin activation	P2RY12 PIEZO1	6.22e-04	14	55	2	GO:0033625
GeneOntologyBiologicalProcess	regulation of membrane lipid distribution	ATP11C ATP11A ATP9A	6.97e-04	65	55	3	GO:0097035
GeneOntologyBiologicalProcess	sensory perception of taste	TAS2R14 TAS1R1 TAS2R39	8.65e-04	70	55	3	GO:0050909
GeneOntologyBiologicalProcess	myotube differentiation	CD9 PIEZO1 KEL ATP11A	9.58e-04	164	55	4	GO:0014902
GeneOntologyCellularComponent	recycling endosome membrane	ZDHHC2 ABCB11 ATP11C ATP9A	2.16e-04	112	55	4	GO:0055038
GeneOntologyCellularComponent	recycling endosome	ZDHHC2 ABCB11 ATP11C ATP11A ATP9A	2.92e-04	222	55	5	GO:0055037
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP11C ATP11A	6.06e-04	14	55	2	GO:1990531
Domain	P_typ_ATPase_c	ATP11C ATP11A ATP9A	7.25e-06	14	52	3	IPR032630
Domain	P-type_ATPase_N	ATP11C ATP11A ATP9A	7.25e-06	14	52	3	IPR032631
Domain	P-type_ATPase_IV	ATP11C ATP11A ATP9A	7.25e-06	14	52	3	IPR006539
Domain	PhoLip_ATPase_C	ATP11C ATP11A ATP9A	7.25e-06	14	52	3	PF16212
Domain	PhoLip_ATPase_N	ATP11C ATP11A ATP9A	7.25e-06	14	52	3	PF16209
Domain	GPCR_Rhodpsn_7TM	P2RY12 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 CCR8 VN1R1 GPR139	1.34e-05	670	52	10	IPR017452
Domain	G_PROTEIN_RECEP_F1_1	P2RY12 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 CCR8 VN1R1 GPR139	1.62e-05	685	52	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	P2RY12 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 CCR8 VN1R1 GPR139	1.74e-05	691	52	10	PS50262
Domain	GPCR_Rhodpsn	P2RY12 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 CCR8 VN1R1 GPR139	1.77e-05	692	52	10	IPR000276
Domain	zf-DHHC	ZDHHC2 ZDHHC20 ZDHHC15	3.47e-05	23	52	3	PF01529
Domain	DHHC	ZDHHC2 ZDHHC20 ZDHHC15	4.48e-05	25	52	3	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC2 ZDHHC20 ZDHHC15	4.48e-05	25	52	3	IPR001594
Domain	7tm_1	P2RY12 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 CCR8 GPR139	9.33e-05	677	52	9	PF00001
Domain	-	ATP11C ATP11A ATP9A	9.54e-05	32	52	3	2.70.150.10
Domain	-	ATP11C ATP11A ATP9A	9.54e-05	32	52	3	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP11C ATP11A ATP9A	1.25e-04	35	52	3	IPR023299
Domain	ATPase_P-typ_P_site	ATP11C ATP11A ATP9A	1.36e-04	36	52	3	IPR018303
Domain	P_typ_ATPase	ATP11C ATP11A ATP9A	1.36e-04	36	52	3	IPR001757
Domain	ATPASE_E1_E2	ATP11C ATP11A ATP9A	1.36e-04	36	52	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP11C ATP11A ATP9A	1.48e-04	37	52	3	IPR008250
Domain	E1-E2_ATPase	ATP11C ATP11A ATP9A	1.48e-04	37	52	3	PF00122
Domain	Olfact_rcpt	OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2	7.51e-04	393	52	6	IPR000725
Domain	-	ATP11C ATP11A ATP9A	7.52e-04	64	52	3	3.40.50.1000
Domain	HAD-like_dom	ATP11C ATP11A ATP9A	1.39e-03	79	52	3	IPR023214
Domain	TAS2R	TAS2R14 TAS2R39	2.37e-03	26	52	2	PF05296
Domain	T2R	TAS2R14 TAS2R39	2.37e-03	26	52	2	IPR007960
Domain	GPCR_2_secretin-like_CS	ADGRG2 PTH1R	4.03e-03	34	52	2	IPR017983
Domain	G_PROTEIN_RECEP_F2_2	ADGRG2 PTH1R	8.55e-03	50	52	2	PS00650
Domain	7tm_2	ADGRG2 PTH1R	8.55e-03	50	52	2	PF00002
Pathway	REACTOME_SENSORY_PERCEPTION	TAS2R14 OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 TAS1R1 OR2S2 OR10J4 TAS2R39	3.04e-05	636	46	10	M41834
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TAS2R14 TAS1R1 TAS2R39	1.37e-04	31	46	3	MM15691
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R14 TAS1R1 TAS2R39	2.34e-04	37	46	3	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R14 TAS1R1 TAS2R39	2.74e-04	39	46	3	M793
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2 OR10J4	3.72e-04	417	46	7	M4072
Pathway	REACTOME_GPCR_LIGAND_BINDING	TAS2R14 P2RY12 TAS1R1 KEL CCR8 TAS2R39 PTH1R	4.48e-04	430	46	7	MM15160
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TAS2R14 TAS1R1 TAS2R39	4.77e-04	47	46	3	M42524
Pathway	KEGG_TASTE_TRANSDUCTION	TAS2R14 TAS1R1 TAS2R39	6.43e-04	52	46	3	M5785
Pathway	REACTOME_GPCR_LIGAND_BINDING	TAS2R14 P2RY12 TAS1R1 KEL CCR8 TAS2R39 PTH1R	6.95e-04	463	46	7	M507
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP11C ATP11A ATP9A	7.58e-04	55	46	3	M971
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP11C ATP11A ATP9A	8.41e-04	57	46	3	MM15643
Pathway	REACTOME_LATE_SARS_COV_2_INFECTION_EVENTS	ZDHHC2 ZDHHC20 ANO10	1.53e-03	70	46	3	M46438
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR5B12 OR6C4 OR10J3 OR6C76 OR6C75 OR2S2	1.56e-03	389	46	6	M14091
Pathway	WP_GPCRS_NONODORANT	TAS2R14 P2RY12 ADGRG2 CCR8 PTH1R	1.68e-03	266	46	5	MM15843
Pathway	WP_GPCRS_ODORANT	TAS2R14 TAS1R1 TAS2R39 GPR139	1.68e-03	157	46	4	MM15872
Pathway	WP_FARNESOID_X_RECEPTOR_PATHWAY	PPARGC1A ABCB11	1.72e-03	19	46	2	M39411
Pubmed	ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.	ATP11C ATP11A ATP9A	8.15e-07	12	55	3	21914794
Pubmed	Differential expression of putative transbilayer amphipath transporters.	ATP11C ATP11A ATP9A	1.06e-06	13	55	3	11015572
Pubmed	Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.	ABCB11 ATP11A G6PC2	1.35e-06	14	55	3	20858683
Pubmed	Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.	ZDHHC2 ZDHHC20 ZDHHC15	2.07e-06	16	55	3	23034182
Pubmed	Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.	TAS2R14 TAS2R39	2.46e-06	2	55	2	21942422
Pubmed	A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.	ABCB11 G6PC2	2.46e-06	2	55	2	19669124
Pubmed	Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up.	SLC17A5 GOT1	2.46e-06	2	55	2	27872510
Pubmed	An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.	ABCB11 G6PC2	2.46e-06	2	55	2	37552875
Pubmed	X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase.	ATP11C ATP11A	2.46e-06	2	55	2	15533723
Pubmed	Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes.	ATP11C ATP11A	2.46e-06	2	55	2	36162506
Pubmed	Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.	ABCB11 G6PC2	2.46e-06	2	55	2	18521185
Pubmed	Identification of PSD-95 palmitoylating enzymes.	ZDHHC2 ZDHHC20 ZDHHC15	2.50e-06	17	55	3	15603741
Pubmed	Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.	PIEZO1 ABCB11 G6PC2	2.50e-06	17	55	3	24647736
Pubmed	Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.	ZDHHC2 ZDHHC20 ZDHHC15	4.19e-06	20	55	3	16647879
Pubmed	DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.	ZDHHC2 CD9	7.36e-06	3	55	2	18508921
Pubmed	Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.	PIEZO1 ATP11A	7.36e-06	3	55	2	29799007
Pubmed	S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.	ZDHHC2 ZDHHC20	7.36e-06	3	55	2	34428449
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C4 OR6C76 OR6C75	7.40e-06	24	55	3	24152035
Pubmed	Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane.	ATP11C ATP11A	1.47e-05	4	55	2	25315773
Pubmed	Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.	ATP11C ATP11A	1.47e-05	4	55	2	30355768
Pubmed	Palmitoylation of SARS-CoV-2 Envelope protein is central to virus particle formation.	ZDHHC20 ZDHHC15	2.45e-05	5	55	2	39287388
Pubmed	Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.	ZDHHC2 ZDHHC15	2.45e-05	5	55	2	28167757
Pubmed	Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium.	ATP11C ATP11A	2.45e-05	5	55	2	26567335
Pubmed	ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum.	ATP11C ATP11A	2.45e-05	5	55	2	31571211
Pubmed	Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.	ABCB11 G6PC2	2.45e-05	5	55	2	19937311
Pubmed	Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin.	CD9 HERC5	3.67e-05	6	55	2	20581239
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	P2RY12 VN1R1 GPR139	5.41e-05	46	55	3	12044878
Pubmed	Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice.	ABCB11 ATP11C	8.78e-05	9	55	2	26926046
Pubmed	The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.	ATP11C ATP9A	1.10e-04	10	55	2	15919184
Pubmed	Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy.	PPARGC1A PTH1R	1.34e-04	11	55	2	27402918
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5B12 OR10J3 OR6C76 OR6C75 OR10D4P	2.02e-04	340	55	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5B12 OR10J3 OR6C76 OR6C75 OR10D4P	2.02e-04	340	55	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5B12 OR10J3 OR6C76 OR6C75 OR10D4P	2.10e-04	343	55	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5B12 OR10J3 OR6C76 OR6C75 OR10D4P	2.19e-04	346	55	5	14611657
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5B12 OR10J3 OR2S2 OR10J4	4.06e-04	219	55	4	12213199
Pubmed	Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.	SLC17A5 ATP11A	5.56e-04	22	55	2	17983586
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R14 TAS2R39	5.56e-04	22	55	2	12734386
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R14 TAS2R39	6.08e-04	23	55	2	20022913
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TTC28 SV2C ATP11A	6.09e-04	104	55	3	10470851
Pubmed	Receptors for bitter and sweet taste.	TAS2R14 TAS2R39	7.20e-04	25	55	2	12139982
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	ABCB11 G6PC2	7.79e-04	26	55	2	19060910
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R14 TAS2R39	7.79e-04	26	55	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R14 TAS2R39	8.40e-04	27	55	2	12581520
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R14 TAS2R39	9.04e-04	28	55	2	15744053
Pubmed	EBF2 determines and maintains brown adipocyte identity.	PPARGC1A ADGRG2	9.70e-04	29	55	2	23499423
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R14 TAS2R39	1.04e-03	30	55	2	12679530
Pubmed	Integral and associated lysosomal membrane proteins.	SLC17A5 ATP11C ATP11A	1.06e-03	126	55	3	17897319
Pubmed	14-3-3ζ coordinates adipogenesis of visceral fat.	PPARGC1A G6PC2	1.33e-03	34	55	2	26220403
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R14 TAS2R39	1.33e-03	34	55	2	15496549
Cytoband	12q13.2	OR6C4 OR6C76 OR6C75	4.08e-05	55	55	3	12q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	NBEAL2 ANO10 QARS1 PTH1R	5.70e-04	316	55	4	chr3p21
Cytoband	1q23.2	OR10J3 OR10J4	8.17e-04	35	55	2	1q23.2
GeneFamily	ATPase phospholipid transporting	ATP11C ATP11A ATP9A	6.42e-06	15	45	3	1210
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC2 ZDHHC20 ZDHHC15	2.81e-05	24	45	3	76
GeneFamily	Olfactory receptors, family 6	OR6C4 OR6C76 OR6C75	2.76e-04	51	45	3	153
GeneFamily	Olfactory receptors, family 10	OR10J3 OR10J4 OR10D4P	5.91e-04	66	45	3	157
GeneFamily	Taste 2 receptors	TAS2R14 TAS2R39	4.23e-03	39	45	2	1162
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL18 P2RY12 ATP11A PTH1R	3.84e-05	156	54	4	d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL18 P2RY12 ATP11A PTH1R	4.04e-05	158	54	4	d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL18 P2RY12 ATP11A PTH1R	4.04e-05	158	54	4	df614450e10629dc9115d7365397663e82f9e48f
ToppCell	VE-CD8-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	TAS2R14 CCR8 URB2 ATP9A	4.35e-05	161	54	4	a114f4f75859d9ef900e5146686438d051241429
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC15 ASB5 CCR8 FAM124B	5.37e-05	170	54	4	aff226a84e397ab58204325aa9d8b396a881986e
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC15 ASB5 CCR8 FAM124B	5.37e-05	170	54	4	6af16e6f276aec6389ece99505ba13c7edc4c4fa
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 CD9 P2RY12 NBEAL2	6.42e-05	178	54	4	63f5880a5b514e20ef2c07a6a9cb8df34e6cede5
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 CD9 P2RY12 NBEAL2	6.42e-05	178	54	4	82c84f8b8a7e6a3d3be3351b348a37143279c100
ToppCell	PND14-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 CD9 P2RY12 NBEAL2	6.42e-05	178	54	4	cb91558469ae0748106fb0b6d702edb0ff21a884
ToppCell	megakaryocytic-Platelet\|World / Lineage and Cell class	CD9 P2RY12 ATP9A ABLIM3	6.70e-05	180	54	4	c007c3e63c2bb35ed34327dd8863899b5db93115
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	MRPS30 ZDHHC15 URB2 PTH1R	7.00e-05	182	54	4	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD9 P2RY12 ATP9A ABLIM3	7.61e-05	186	54	4	9e2e8e2c3de711734cdb4775bafb0757b4db97b1
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD9 P2RY12 ATP9A ABLIM3	7.61e-05	186	54	4	1dfd3fc4012bf0254adfa1f5eddadc9b6107455b
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD9 P2RY12 ATP9A ABLIM3	7.61e-05	186	54	4	107bc473f5e57238390f8e0ab9f7263a8f93948c
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD9 P2RY12 ATP9A ABLIM3	7.61e-05	186	54	4	8fbf5cb31192066b4c202f80baf6d7f2bdefedb9
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Hematopoietic-Megakaryocytic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD9 P2RY12 ATP9A ABLIM3	7.61e-05	186	54	4	49d23c985b2f5e16790f4d7ccf81ef7b794c0877
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD9 P2RY12 ATP9A ABLIM3	7.61e-05	186	54	4	13a9ddcf93b0c4319ab9d484af5e2056e9754caa
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	CD9 NBEAL2 ATP11A PTH1R	9.69e-05	198	54	4	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD9 SPINT1 ATP11A PTH1R	1.01e-04	200	54	4	33b7af6c50e65dc1bdf429572574ed072f8bc29f
ToppCell	background-Hepatocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	PPARGC1A ABCB11 ABLIM3 GOT1	1.01e-04	200	54	4	423cca10df6ae0489a8fe7e7df87e70364dac022
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD9 SPINT1 ATP11A PTH1R	1.01e-04	200	54	4	741e59c68ae4a3a7be830e98771a14f920c9e883
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD9 SPINT1 ATP11A PTH1R	1.01e-04	200	54	4	55b7b17f2d413b9ebb262ef8bd210ef45618a7f3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD9 SPINT1 ATP11A PTH1R	1.01e-04	200	54	4	d9dab2aed11e45c60d11ff0c5af1f2fbb9cb45d8
Disease	syndrome (implicated_via_orthology)	ZDHHC2 ZDHHC20 ZDHHC15	4.13e-06	18	52	3	DOID:225 (implicated_via_orthology)
Disease	aspartate aminotransferase measurement	SLC17A5 PPARGC1A TTC28 PIEZO1 ABCB11 CCR8 GOT1	9.96e-04	904	52	7	EFO_0004736
Disease	HbA1c measurement	PIEZO1 TAS1R1 ABCB11 KEL ATP11A G6PC2	1.17e-03	675	52	6	EFO_0004541
Disease	amyotrophic lateral sclerosis (is_implicated_in)	PPARGC1A GOT1	1.46e-03	32	52	2	DOID:332 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLDSYFKEGNQLLCF	URB2	311	Q14146
LAQSGFFFKNQEYIC	ABLIM3	56	O94929
FVSCLNFLFFLVYFN	ALG6	476	Q9Y672
IFNTLQGFFIFIFYC	ADGRG2	866	Q8IZP9
QGFFIFIFYCVAKEN	ADGRG2	871	Q8IZP9
FKTAIQKANIYGFCF	ABCB11	971	O95342
AILLCNFFLYFGKKA	CC2D2B	1186	Q6DHV5
FNYREFNKGSLFYLC	ARMCX2	586	Q7L311
SAYACFLFAPLFFQQ	RAD9A	46	Q99638
VFNFLNCFASLFYIA	ANO10	406	Q9NW15
NCFASLFYIAFVLKD	ANO10	411	Q9NW15
LFLFSSFYLCTLLGN	OR10D4P	26	Q8NGN7
QFKYFFNLYFLLLAC	ATP9A	76	O75110
YFFLGNLSFLDICFT	OR2S2	61	Q9NQN1
GDKFILYNACATQFF	OR5B12	86	Q96R08
FIYFFLCKSFRNSLI	P2RY12	296	Q9H244
SFAGCLTQYFFAIFL	OR6C4	91	Q8NGE1
YNACAAQLFFFIFLG	OR6C76	91	A6NM76
RYFFFGVLCGLSLFN	HERC5	766	Q9UII4
FELYFCGRKQFFKSN	PPARGC1A	746	Q9UBK2
ALFYLFSAFGNILSC	PABPC5	121	Q96DU9
FFNLLAVLSYLKFFN	POMT1	161	Q9Y6A1
GTKCIKYLLFGFNFI	CD9	6	P21926
LQKSNFCFFVLYASK	FAM124B	166	Q9H5Z6
FCFFVLYASKSFALQ	FAM124B	171	Q9H5Z6
LLFICFLAYSQGAFE	CASD1	561	Q96PB1
FYCLLFVFSLLGNSL	CCR8	41	P51685
FEAGQYFNKIQCFCF	COX11	206	Q9Y6N1
FFCAQSFSKNFGLYN	GOT1	251	P17174
NVYFTILSLFCFKLF	ASB5	16	Q8WWX0
RNIFFIYFPLCFQFN	G6PC2	36	Q9NQR9
LNTAINFFLYCFISK	GPR139	276	Q6DWJ6
CSARYNLAILAFFGF	SLC17A5	36	Q9NRA2
RFFFDVGCNKYGVFL	PURB	231	Q96QR8
SYNGCVAQLFFFIFL	OR6C75	91	A6NL08
KVFFLFYSFFNPTLN	OR2A1;	271	Q8NGT9
QLFFYLTFGINNCFL	OR10J3	101	Q5JRS4
QLFFYLTFGVNKCFL	OR10J4	101	P0C629
ITDGKYFSFFCYQLN	MRPS30	361	Q9NP92
FNFGYAKANNGICFL	QARS1	286	P47897
FYFLKIANFSNSIFL	TAS2R14	106	Q9NYV8
YAFKISFIFLNFCSL	TAS2R39	111	P59534
SFVQGYGFFLFCRLL	SV2C	236	Q496J9
FKNLDYASIFFLVCL	FBXL18	741	Q96ME1
FFIDQANYFLNFPCK	NBEAL2	1991	Q6ZNJ1
VCFIFPQFLYQFFCG	ATP11A	891	P98196
CFILPQFLYQFFCGF	ATP11C	886	Q8NB49
NCVGFSNYKFFLLFL	ZDHHC20	161	Q5W0Z9
YNEAKCVTFSLLFNF	TAS1R1	756	Q7RTX1
LFNSFQGFFVAIIYC	PTH1R	446	Q03431
AILGYCFFKNQRKDF	SPINT1	481	O43278
LGNSFLLCFYNLILF	VN1R1	61	Q9GZP7
RNLFFFLCLNLSFAF	SLC30A7	36	Q8NEW0
AYCNLGLAFKALLNF	TTC28	676	Q96AY4
NNCVGFSNYKFFLLF	ZDHHC2	161	Q9UIJ5
DQDLLGCLKYFINFF	PIEZO1	976	Q92508
FINFFFYKFGLEICF	PIEZO1	986	Q92508
TLAFLGLFFLYCKQF	EDA2R	151	Q9HAV5
IGFSNYKFFLQFLAY	ZDHHC15	166	Q96MV8
GLLLCFSVLLFYNFQ	KEL	56	P23276