Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

FZD1 FZD6 FZD7 IL12B CELSR2 HTR6 GPR32 GPR32P1 P2RY11 IL17RE OPN3 FZD5 OR2D3 OPN5 RXFP4 GRIK4 GRIK5 ADGRE1 PKD1L3 OR6T1 ABCA7 GABRA1

1.23e-0713539122GO:0004888
GeneOntologyMolecularFunctionWnt-protein binding

FZD1 FZD6 FZD7 FZD5 WIF1

4.41e-0734915GO:0017147
GeneOntologyMolecularFunctionWnt receptor activity

FZD1 FZD6 FZD7 FZD5

9.18e-0717914GO:0042813
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 WDR77

2.01e-0682916GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 WDR77

4.76e-0695916GO:0140767
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

5.11e-0655915GO:0042974
GeneOntologyMolecularFunctionG protein-coupled receptor activity

FZD1 FZD6 FZD7 CELSR2 HTR6 GPR32 GPR32P1 P2RY11 OPN3 FZD5 OR2D3 OPN5 RXFP4 ADGRE1 OR6T1

1.03e-058849115GO:0004930
GeneOntologyMolecularFunctionphotoreceptor activity

CRY2 OPN3 OPN5

5.94e-0517913GO:0009881
GeneOntologyMolecularFunctionneurotransmitter receptor activity

HTR6 P2RY11 GRIK4 GRIK5 GABRA1

9.42e-05100915GO:0030594
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK4 GRIK5 GABRA1

1.73e-0424913GO:0099507
GeneOntologyMolecularFunctionN-formyl peptide receptor activity

GPR32 GPR32P1

2.04e-045912GO:0004982
GeneOntologyMolecularFunctionnuclear receptor binding

CRY2 PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

2.15e-04187916GO:0016922
GeneOntologyMolecularFunctionmannosyltransferase activity

POMT2 DPY19L2 DPY19L2P2

2.76e-0428913GO:0000030
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK4 GRIK5

3.04e-046912GO:0015277
GeneOntologyMolecularFunction11-cis retinal binding

OPN3 OPN5

4.25e-047912GO:0005502
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A18 CLCN5 ABCB9 SLC6A16 HPX OTOP1 TCIRG1 GRIK4 GRIK5 PKD1L3 ABCA7 SLC7A14 SLC39A13 GABRA1

8.76e-0411809114GO:0022857
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A18 GRIK4 GRIK5 SLC7A14

1.36e-03105914GO:0015171
GeneOntologyMolecularFunctioncomplement receptor activity

GPR32 GPR32P1

1.80e-0314912GO:0004875
GeneOntologyMolecularFunctiontransporter activity

SLC6A18 CLCN5 ABCB9 SLC6A16 HPX OTOP1 TCIRG1 GRIK4 GRIK5 PKD1L3 ABCA7 SLC7A14 SLC39A13 GABRA1

2.02e-0312899114GO:0005215
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

OPN3 OPN5

2.08e-0315912GO:0008020
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIK4 GRIK5 GABRA1

2.24e-0357913GO:1904315
GeneOntologyMolecularFunctionoxysterol binding

INSIG1 INSIG2

2.36e-0316912GO:0008142
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIK4 GRIK5 GABRA1

2.60e-0360913GO:0099529
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK4 GRIK5

2.67e-0317912GO:0004970
GeneOntologyMolecularFunctionligand-gated sodium channel activity

GRIK4 GRIK5

3.00e-0318912GO:0015280
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIK4 GRIK5 GABRA1

3.26e-0365913GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIK4 GRIK5 GABRA1

3.26e-0365913GO:0022824
GeneOntologyMolecularFunctionretinal binding

OPN3 OPN5

4.08e-0321912GO:0016918
GeneOntologyMolecularFunctionsterol binding

GPR155 INSIG1 INSIG2

4.18e-0371913GO:0032934
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIK4 GRIK5 GABRA1

4.88e-0375913GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GRIK4 GRIK5 GABRA1

5.25e-0377913GO:0005230
GeneOntologyBiologicalProcessSREBP-SCAP complex retention in endoplasmic reticulum

INSIG1 INSIG2

1.88e-052902GO:0036316
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

FZD1 FZD6 FZD7 CELSR2 FZD5

2.18e-0577905GO:0035567
GeneOntologyBiologicalProcessmaintenance of protein localization in endoplasmic reticulum

INSIG1 INSIG2 GRIK5

3.52e-0515903GO:0035437
GeneOntologyBiologicalProcessnegative regulation of SREBP signaling pathway

INSIG1 INSIG2

5.63e-053902GO:2000639
GeneOntologyBiologicalProcessoocyte development

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 WDR77

7.32e-0599905GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 WDR77

8.84e-05103905GO:0009994
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

FZD1 FZD6 FZD7 CELSR2

9.75e-0555904GO:0060071
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

FZD1 FZD6 FZD7 PDE3B CELSR2 HTR6 GPR32 GPR32P1 P2RY11 OPN3 FZD5 ATRNL1 OR2D3 OPN5 RXFP4 ADGRE1 OR6T1

9.79e-0513959017GO:0007186
GeneOntologyBiologicalProcessprotein mannosylation

POMT2 DPY19L2 DPY19L2P2

1.72e-0425903GO:0035268
GeneOntologyBiologicalProcesscholesterol biosynthetic process

INSIG1 EBP INSIG2 PLPP6

1.87e-0465904GO:0006695
GeneOntologyBiologicalProcesssecondary alcohol biosynthetic process

INSIG1 EBP INSIG2 PLPP6

1.87e-0465904GO:1902653
GeneOntologyBiologicalProcessmannosylation

POMT2 DPY19L2 DPY19L2P2

1.94e-0426903GO:0097502
GeneOntologyBiologicalProcesscellular response to sterol

GPR155 INSIG1 INSIG2

1.94e-0426903GO:0036315
GeneOntologyBiologicalProcesssterol biosynthetic process

INSIG1 EBP INSIG2 PLPP6

2.78e-0472904GO:0016126
GeneOntologyBiologicalProcesspeptidyl-tryptophan modification

DPY19L2 DPY19L2P2

2.79e-046902GO:0018211
GeneOntologyBiologicalProcessprotein C-linked glycosylation via tryptophan

DPY19L2 DPY19L2P2

2.79e-046902GO:0018317
GeneOntologyBiologicalProcessprotein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan

DPY19L2 DPY19L2P2

2.79e-046902GO:0018406
GeneOntologyBiologicalProcessprotein C-linked glycosylation

DPY19L2 DPY19L2P2

2.79e-046902GO:0018103
GeneOntologyBiologicalProcessresponse to blue light

CRY2 OPN3

2.79e-046902GO:0009637
GeneOntologyBiologicalProcessblastocyst formation

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

3.78e-0478904GO:0001825
GeneOntologyBiologicalProcessnegative regulation of apoptotic process

FZD1 PRAMEF33 TMEM161A PRAMEF10 TNFSF18 ATAD3A OPN3 PRAMEF19 SUPV3L1 DNAJC5 PRAMEF17 PRAMEF18 MUC4 PHIP

3.80e-0411339014GO:0043066
GeneOntologyBiologicalProcessresponse to sterol

GPR155 INSIG1 INSIG2

4.36e-0434903GO:0036314
GeneOntologyBiologicalProcessregulation of SREBP signaling pathway

INSIG1 INSIG2

5.18e-048902GO:2000638
GeneOntologyBiologicalProcessnegative regulation of programmed cell death

FZD1 PRAMEF33 TMEM161A PRAMEF10 TNFSF18 ATAD3A OPN3 PRAMEF19 SUPV3L1 DNAJC5 PRAMEF17 PRAMEF18 MUC4 PHIP

5.28e-0411719014GO:0043069
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell activation

IL12B TNFSF18 TCIRG1 NKG7 VSIR

5.57e-04153905GO:0035710
GeneOntologyBiologicalProcessalcohol biosynthetic process

ACER1 INSIG1 EBP INSIG2 PLPP6

5.74e-04154905GO:0046165
GeneOntologyBiologicalProcessregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

IL12B TNFSF18 FZD5 HPX MUC4 VSIR

5.75e-04235906GO:0002822
GeneOntologyBiologicalProcessoogenesis

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 WDR77

6.08e-04156905GO:0048477
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.86e-0647915GO:0031462
GeneOntologyCellularComponentSREBP-SCAP-Insig complex

INSIG1 INSIG2

5.61e-053912GO:0032937
GeneOntologyCellularComponentcell surface

FZD1 FZD6 IL12B TNFSF18 FZD5 SCARB1 WIF1 CD48 DCSTAMP ADGRE1 PKD1L3 ZZEF1 ABCA7 VSIR CD163

8.50e-0511119115GO:0009986
GeneOntologyCellularComponentlysosomal membrane

GPR155 CLCN5 ABCB9 MARCHF9 SCARB1 TCIRG1 DNAJC5 NKG7 SLC7A14

1.84e-04462919GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

GPR155 CLCN5 ABCB9 MARCHF9 SCARB1 TCIRG1 DNAJC5 NKG7 SLC7A14

1.84e-04462919GO:0098852
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK4 GRIK5

2.78e-046912GO:0032983
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 WDR77

3.30e-04212916GO:0031461
GeneOntologyCellularComponentvacuolar membrane

GPR155 CLCN5 ABCB9 MARCHF9 SCARB1 TCIRG1 DNAJC5 NKG7 SLC7A14

3.64e-04507919GO:0005774
GeneOntologyCellularComponentendoplasmic reticulum membrane

POMT2 FZD6 ACER1 ABCB9 TMEM178A INSIG1 EBP INSIG2 DIPK1B DCSTAMP SLC39A13 PLPP6 RETREG3 DUOXA2

1.36e-0312939114GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

POMT2 FZD6 ACER1 ABCB9 TMEM178A INSIG1 EBP INSIG2 DIPK1B DCSTAMP SLC39A13 PLPP6 RETREG3 DUOXA2

1.42e-0312999114GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

POMT2 FZD6 ACER1 ABCB9 TMEM178A INSIG1 EBP INSIG2 DIPK1B DCSTAMP SLC39A13 PLPP6 RETREG3 DUOXA2

1.73e-0313279114GO:0042175
GeneOntologyCellularComponentnuclear inner membrane

DPY19L2 DPY19L2P2 PLPP6

2.18e-0359913GO:0005637
MousePhenoabnormal spermatogonia proliferation

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

5.34e-0647765MP:0002685
MousePhenoincreased kidney weight

PRAMEF33 PRAMEF10 PRAMEF19 TCIRG1 PRAMEF17 PRAMEF18 ZZEF1

1.34e-05145767MP:0003917
MousePhenoabnormal circulating amylase level

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 RETREG3 DUOXA2

2.16e-05156767MP:0008804
MousePhenoincreased circulating amylase level

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 RETREG3

4.51e-05119766MP:0008806
MousePhenoabnormal jejunum morphology

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

7.01e-0541764MP:0004002
MousePhenoabnormal kidney weight

PRAMEF33 PRAMEF10 PRAMEF19 TCIRG1 PRAMEF17 PRAMEF18 ZZEF1

1.34e-04208767MP:0002707
MousePhenoabnormal sperm individualization

DPY19L2 DPY19L2P2

1.74e-044762MP:0031372
DomainFrizzled

FZD1 FZD6 FZD7 FZD5

1.48e-0711884IPR000539
DomainFrizzled

FZD1 FZD6 FZD7 FZD5

1.48e-0711884PF01534
DomainFrizzled

FZD1 FZD6 FZD7 FZD5

1.48e-0711884SM01330
DomainGPCR_2-like

FZD1 FZD6 FZD7 CELSR2 FZD5 ADGRE1

3.76e-0760886IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD1 FZD6 FZD7 CELSR2 FZD5 ADGRE1

4.15e-0761886PS50261
DomainFrizzled/SFRP

FZD1 FZD6 FZD7 FZD5

8.02e-0716884IPR015526
DomainPRAME_family

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.69e-0619884IPR026271
DomainFRI

FZD1 FZD6 FZD7 FZD5

2.10e-0620884SM00063
Domain-

FZD1 FZD6 FZD7 FZD5

2.59e-06218841.10.2000.10
DomainFrizzled_dom

FZD1 FZD6 FZD7 FZD5

4.55e-0624884IPR020067
DomainFZ

FZD1 FZD6 FZD7 FZD5

4.55e-0624884PS50038
DomainFz

FZD1 FZD6 FZD7 FZD5

4.55e-0624884PF01392
DomainGPCR_2_secretin-like

FZD1 FZD6 FZD7 CELSR2 ADGRE1

9.22e-0660885IPR000832
DomainTransmembrane_161A/B

TMEM161A TMEM161B

2.19e-052882IPR019395
DomainINSIG_fam

INSIG1 INSIG2

2.19e-052882IPR025929
DomainTmemb_161AB

TMEM161A TMEM161B

2.19e-052882PF10268
DomainINSIG

INSIG1 INSIG2

2.19e-052882PF07281
DomainINSIG-1

INSIG1 INSIG2

2.19e-052882IPR009904
DomainEGF

CELSR2 ATRNL1 WIF1 LAMA4 ADGRE1 MUC4 TMEFF2

1.22e-04235887SM00181
DomainEGF-like_dom

CELSR2 ATRNL1 WIF1 LAMA4 ADGRE1 MUC4 TMEFF2

1.74e-04249887IPR000742
DomainEGF_1

CELSR2 ATRNL1 WIF1 LAMA4 ADGRE1 MUC4 TMEFF2

2.02e-04255887PS00022
DomainEGF-like_CS

CELSR2 ATRNL1 WIF1 LAMA4 ADGRE1 MUC4 TMEFF2

2.33e-04261887IPR013032
DomainPIP49_C

DIPK1B DIPK2B

3.25e-046882PF12260
DomainFAM69_kinase_dom

DIPK1B DIPK2B

3.25e-046882IPR022049
DomainEGF_LAM_2

CELSR2 ATRNL1 LAMA4

3.74e-0430883PS50027
DomainEGF_LAM_1

CELSR2 ATRNL1 LAMA4

3.74e-0430883PS01248
DomainGPS

CELSR2 ADGRE1 PKD1L3

5.44e-0434883SM00303
DomainGPS

CELSR2 ADGRE1 PKD1L3

5.93e-0435883PF01825
DomainEGF_Lam

CELSR2 ATRNL1 LAMA4

5.93e-0435883SM00180
DomainMARCH-like

MARCHF9 MARCHF11

6.03e-048882IPR033275
DomainRetinal_BS

OPN3 OPN5

6.03e-048882IPR027430
DomainGPS

CELSR2 ADGRE1 PKD1L3

6.45e-0436883PS50221
DomainGPS

CELSR2 ADGRE1 PKD1L3

6.99e-0437883IPR000203
DomainLaminin_EGF

CELSR2 ATRNL1 LAMA4

7.57e-0438883IPR002049
DomainEGF_3

CELSR2 ATRNL1 WIF1 ADGRE1 MUC4 TMEFF2

8.54e-04235886PS50026
DomainOPSIN

OPN3 OPN5

9.64e-0410882PS00238
DomainRINGv

MARCHF9 MARCHF11

1.17e-0311882PF12906
DomainOpsin

OPN3 OPN5

1.17e-0311882IPR001760
DomainZF_RING_CH

MARCHF9 MARCHF11

1.17e-0311882PS51292
DomainEGF_2

CELSR2 ATRNL1 WIF1 ADGRE1 MUC4 TMEFF2

1.58e-03265886PS01186
DomainZnf_RING-CH

MARCHF9 MARCHF11

2.85e-0317882IPR011016
DomainRINGv

MARCHF9 MARCHF11

2.85e-0317882SM00744
DomainEGF

CELSR2 WIF1 MUC4 TMEFF2

2.98e-03126884PF00008
DomainIontro_rcpt

GRIK4 GRIK5

3.20e-0318882IPR001320
DomainLig_chan-Glu_bd

GRIK4 GRIK5

3.20e-0318882PF10613
DomainIono_rcpt_met

GRIK4 GRIK5

3.20e-0318882IPR001508
DomainGlu/Gly-bd

GRIK4 GRIK5

3.20e-0318882IPR019594
DomainNA_NEUROTRAN_SYMP_2

SLC6A18 SLC6A16

3.20e-0318882PS00754
DomainLig_chan-Glu_bd

GRIK4 GRIK5

3.20e-0318882SM00918
DomainLig_chan

GRIK4 GRIK5

3.20e-0318882PF00060
DomainPBPe

GRIK4 GRIK5

3.20e-0318882SM00079
DomainSNF

SLC6A18 SLC6A16

3.56e-0319882PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A18 SLC6A16

3.56e-0319882PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A18 SLC6A16

3.56e-0319882PS50267
DomainNa/ntran_symport

SLC6A18 SLC6A16

3.56e-0319882IPR000175
DomainWD40_repeat_CS

PRPF4 CIAO1 WDR77 PHIP

7.55e-03164884IPR019775
DomainhEGF

CELSR2 WIF1

7.66e-0328882PF12661
DomainWD40_repeat

PRPF4 FBXW12 CIAO1 WDR77 PHIP

9.27e-03272885IPR001680
PathwayPID_WNT_SIGNALING_PATHWAY

FZD1 FZD6 FZD7 FZD5 WIF1

1.17e-0728615M77
PathwayWP_GPCRS_NONODORANT

FZD1 FZD6 FZD7 CELSR2 HTR6 OPN3 FZD5 OPN5 RXFP4 ADGRE1

1.87e-072666110MM15843
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD1 FZD6 FZD7 FZD5

3.07e-0714614M47834
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD1 FZD6 FZD7 FZD5

5.55e-0716614M47823
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD1 FZD6 FZD7 FZD5

1.17e-0619614M47833
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD6 FZD7 FZD5

1.69e-0536614M39699
PathwayREACTOME_GPCR_LIGAND_BINDING

FZD1 FZD6 FZD7 HTR6 P2RY11 OPN3 FZD5 OPN5 RXFP4 ADGRE1

2.66e-054636110M507
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD1 FZD6 FZD7 FZD5

3.78e-0544614MM15878
PathwayREACTOME_SIGNALING_BY_GPCR

FZD1 FZD6 FZD7 PDE3B HTR6 GPR32 P2RY11 OPN3 FZD5 OPN5 RXFP4 ADGRE1

3.89e-057026112M746
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

FZD1 FZD6 FZD7 FZD5 WIF1

4.03e-0589615M39563
PathwayWNT_SIGNALING

FZD1 FZD6 FZD7 FZD5 WIF1

4.03e-0589615M5493
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD1 FZD6 FZD7 FZD5

4.14e-0545614M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD1 FZD6 FZD7 FZD5

4.52e-0546614M47409
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

FZD1 FZD6 FZD7 FZD5 ADGRE1

5.25e-0594615M797
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

FZD1 FZD6 FZD7 FZD5 WIF1

6.40e-0598615M39731
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD1 FZD6 FZD7 FZD5

9.18e-0555614M17807
PathwayWP_WNT_SIGNALING_WP428

FZD1 FZD6 FZD7 FZD5 WIF1

1.26e-04113615M39669
PathwayWP_WNT_SIGNALING

FZD1 FZD6 FZD7 FZD5

1.38e-0461614MM15893
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

FZD1 FZD6 FZD7 FZD5

1.87e-0466614M39642
PathwayPID_WNT_NONCANONICAL_PATHWAY

FZD6 FZD7 FZD5

3.50e-0432613M23
PathwayKEGG_WNT_SIGNALING_PATHWAY

FZD1 FZD6 FZD7 FZD5 WIF1

4.84e-04151615M19428
PathwayREACTOME_PCP_CE_PATHWAY

FZD1 FZD6 FZD7 FZD5

4.95e-0485614MM15041
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

FZD1 FZD6 FZD7 FZD5

4.95e-0485614M48315
PathwayREACTOME_SIGNALING_BY_RNF43_MUTANTS

FZD6 FZD5

5.07e-048612M27433
PathwayREACTOME_OPSINS

OPN3 OPN5

6.50e-049612M6285
PathwayREACTOME_PCP_CE_PATHWAY

FZD1 FZD6 FZD7 FZD5

6.67e-0492614M27322
PathwayWP_GPCRS_OTHER

FZD1 FZD7 CELSR2 FZD5

7.83e-0496614MM15939
PathwayREACTOME_OPSINS

OPN3 OPN5

8.11e-0410612MM15063
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK4 GRIK5

8.11e-0410612M10272
PathwayKEGG_MELANOGENESIS

FZD1 FZD6 FZD7 FZD5

9.47e-04101614M7761
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

FZD1 FZD6 FZD7 FZD5

9.47e-04101614MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

FZD1 FZD6 FZD7 FZD5

9.47e-04101614M39387
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK4 GRIK5

1.18e-0312612MM15142
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

CLCN5 SCARB1 INSIG1 EBP INSIG2 CD163 PLPP6

1.24e-03381617M48063
PathwayWP_WNT_SIGNALING_PATHWAY

FZD1 FZD6 FZD7 FZD5

1.30e-03110614MM15977
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

FZD1 FZD6 FZD7 FZD5

1.58e-03116614MM15863
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

FZD1 FZD6 FZD7 FZD5

1.63e-03117614M39530
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

FZD1 FZD6 FZD7 FZD5

1.69e-03118614M39852
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD1 FZD6 FZD7 FZD5

1.96e-03123614MM14988
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD7 FZD5

2.21e-0360613MM15150
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

SCARB1 HPX CD163

2.21e-0360613MM14872
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

FZD1 FZD7

2.40e-0317612M39525
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD1 FZD7 FZD5

2.66e-0364613M27396
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

FZD6 FZD5

3.33e-0320612MM15155
PathwayWP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING

SCARB1 INSIG1 INSIG2

3.58e-0371613M39395
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

FZD1 FZD6 FZD7 FZD5

3.65e-03146614M27288
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

FZD6 FZD5

3.67e-0321612M27401
PathwayBIOCARTA_WNT_PATHWAY

FZD1 WIF1

4.40e-0323612MM1527
PathwayREACTOME_METABOLISM_OF_STEROIDS

INSIG1 EBP INSIG2 PLPP6

4.41e-03154614M27832
PathwayWP_BREAST_CANCER_PATHWAY

FZD1 FZD6 FZD7 FZD5

4.41e-03154614M39739
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

PDE3B HTR6 GPR32 P2RY11

4.72e-03157614M4904
PathwayBIOCARTA_WNT_PATHWAY

FZD1 WIF1

4.78e-0324612M16517
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

FZD1 FZD6 FZD7 FZD5

5.16e-03161614M39770
PathwayWP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA

FZD6 WIF1

5.60e-0326612M39407
PathwayREACTOME_CHOLESTEROL_BIOSYNTHESIS

EBP PLPP6

6.03e-0327612M16227
PathwayREACTOME_CHOLESTEROL_BIOSYNTHESIS

EBP PLPP6

6.03e-0327612MM14735
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF33 PRAMEF10 FBXW12 PRAMEF19 PRAMEF17 PRAMEF18

1.64e-103092638786026
Pubmed

Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.

FZD1 FZD6 FZD7 FZD5

2.29e-10592419543507
Pubmed

Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).

FZD1 FZD6 FZD7 FZD5

1.59e-09792415370539
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.74e-092092526694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

2.95e-092292531729367
Pubmed

Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.

FZD1 FZD6 FZD7 FZD5

3.18e-09892410559494
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

5.91e-092592537451217
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD1 FZD6 FZD7 FZD5

9.51e-091092415245425
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD1 FZD6 FZD7 FZD5

9.51e-091092417532316
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.09e-082892525089626
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD1 FZD6 FZD7 FZD5

1.49e-081192424860427
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD1 FZD6 FZD7 FZD5

1.49e-081192430978219
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD1 FZD6 FZD7 FZD5

1.49e-081192417582687
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD1 FZD6 FZD7 FZD5

1.49e-081192417576136
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

3.54e-083592519389355
Pubmed

Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.

FZD1 FZD6 FZD7 FZD5 WIF1

5.44e-083892521041481
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.06e-071792423565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.06e-071792437781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.36e-071892423894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.36e-071892412890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.36e-071892429731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.36e-071892414675769
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.36e-071892439181896
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

FZD1 FZD6 FZD7 CELSR2 FZD5

1.63e-074792533141892
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.72e-071992428604677
Pubmed

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

FZD1 FZD6 FZD7 FZD5

1.72e-071992421623369
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

2.15e-072092416580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

2.15e-072092421425410
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

2.24e-075092531806660
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD1 FZD6 FZD7 FZD5

3.23e-072292417064353
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

3.91e-072392419480014
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

5.56e-072592412620990
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

FZD1 FZD6 FZD7 FZD5

5.56e-072592412812787
Pubmed

Myocilin is a modulator of Wnt signaling.

FZD1 FZD7 WIF1

6.22e-07792319188438
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

6.55e-072692418500982
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD1 FZD6 FZD7 FZD5

1.04e-062992418364260
Pubmed

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells.

FZD6 FZD7 FZD5

1.49e-0699239160667
Pubmed

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

FZD1 FZD7 FZD5

1.49e-0699239707618
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.56e-063292437889087
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

FZD1 FZD6 FZD7 PRAMEF10 FBXW12 FZD5 PRAMEF19 PRAMEF17 PRAMEF18

1.94e-0642492921731673
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

CRY2 FZD7 TMEM161A HTR6 METTL9 SCARB1 INSIG1 RXFP4 ABCA7 SLC39A13 TMEFF2

2.39e-06697921128298427
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD1 FZD6 FZD7 FZD5

2.53e-063692424151333
Pubmed

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.

FZD6 FZD7 FZD5 WIF1

2.53e-063692412412008
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

PRAMEF33 PRAMEF10 FBXW12 PRAMEF19 EBP ABHD13 PRAMEF17 PRAMEF18

2.57e-0632692817015433
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

FZD1 FZD6 FZD7 FZD5

2.83e-063792435831952
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

FZD1 FZD6 FZD7 FZD5

2.83e-063792415342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

FZD1 FZD6 FZD7 FZD5

2.83e-063792418800919
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

FZD1 FZD6 FZD7 FZD5

3.16e-063892418635608
Pubmed

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

FZD1 FZD6 FZD7 FZD5 WIF1

4.27e-069092519515997
Pubmed

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.

FZD1 FZD7 CELSR2

5.03e-061392321246654
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

6.87e-064692417287250
Pubmed

High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling.

GRIK4 GRIK5

6.92e-06292219778510
Pubmed

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.

INSIG1 INSIG2

6.92e-06292220090767
Pubmed

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

INSIG1 INSIG2

6.92e-06292219638338
Pubmed

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

INSIG1 INSIG2

6.92e-06292216955138
Pubmed

Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.

INSIG1 INSIG2

6.92e-06292219360322
Pubmed

The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.

INSIG1 INSIG2

6.92e-06292218989534
Pubmed

Subunit-specific desensitization of heteromeric kainate receptors.

GRIK4 GRIK5

6.92e-06292220026616
Pubmed

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.

INSIG1 INSIG2

6.92e-06292219617589
Pubmed

Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.

DPY19L2 DPY19L2P2

6.92e-06292222764053
Pubmed

Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.

GRIK4 GRIK5

6.92e-06292222203159
Pubmed

Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.

INSIG1 INSIG2

6.92e-06292220877301
Pubmed

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

INSIG1 INSIG2

6.92e-06292212624180
Pubmed

Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.

DPY19L2 DPY19L2P2

6.92e-06292225354700
Pubmed

Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.

DPY19L2 DPY19L2P2

6.92e-06292225354701
Pubmed

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.

INSIG1 INSIG2

6.92e-06292224337570
Pubmed

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

FZD1 FZD6 FZD7 FZD5

7.50e-064792428813421
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

FZD1 FZD6 FZD7 FZD5

7.50e-064792418351675
Pubmed

Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.

FZD1 FZD6 FZD7 FZD5

8.87e-064992419562671
Pubmed

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

FZD1 FZD6 FZD7 FZD5

9.62e-065092427510977
Pubmed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

FZD1 FZD7 FZD5

1.19e-051792328733458
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

FZD6 PRAMEF10 CLCN5 OPN3 PRAMEF19 EBP PRAMEF17 KLHL34 DCSTAMP PRAMEF18

1.21e-05674921037196079
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.74e-055892431598710
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.87e-055992411279525
Pubmed

SPRR2C, DEFB4A, WIF1, CRY2, and KRT19 are correlated with the development of atopic eczema.

CRY2 WIF1

2.07e-05392233629313
Pubmed

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.

INSIG1 INSIG2

2.07e-05392231953408
Pubmed

Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.

DPY19L2 DPY19L2P2

2.07e-05392225775128
Pubmed

Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

FZD1 FZD7

2.07e-0539229813155
Pubmed

Cloning genes encoding receptors related to chemoattractant receptors.

GPR32 GPR32P1

2.07e-0539229653656
Pubmed

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

FZD1 FZD7

2.07e-05392227680706
Pubmed

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.

INSIG1 INSIG2

2.07e-05392234298014
Pubmed

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

INSIG1 INSIG2

2.07e-05392212482938
Pubmed

Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing?

OPN3 OPN5

2.07e-05392230168605
Pubmed

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

FZD7 FZD5

2.07e-05392225892522
Pubmed

The expansion of the PRAME gene family in Eutheria.

PRAMEF19 PRAMEF18

2.07e-05392221347312
Pubmed

Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.

GRIK4 GRIK5

2.07e-05392216325263
Pubmed

Duplication and relocation of the functional DPY19L2 gene within low copy repeats.

DPY19L2 DPY19L2P2

2.07e-05392216526957
Pubmed

Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.

INSIG1 INSIG2

2.07e-05392224806461
Pubmed

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.

INSIG1 INSIG2

2.07e-05392216549805
Pubmed

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.

FZD1 FZD7

2.07e-05392235296808
Pubmed

Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands.

INSIG1 INSIG2

2.07e-05392231558435
Pubmed

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

FZD7 FZD5

2.07e-05392228600348
Pubmed

Integral and associated lysosomal membrane proteins.

CLCN5 ABCB9 SCARB1 TCIRG1 DNAJC5

2.20e-0512692517897319
Pubmed

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.

FZD6 FZD7 CELSR2 WIF1

2.58e-056492424431302
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

DPY19L2 IL17RE TMEM178A WIF1 DPY19L2P2 VSIR TMEFF2 SLC35F5

3.11e-0546092820562862
Pubmed

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

FZD6 FZD7 FZD5

3.48e-05249239096311
Pubmed

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

FZD6 FZD7 FZD5

3.48e-05249238626800
Pubmed

Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.

GRIK4 GRIK5

4.14e-05492212954862
Pubmed

A novel predicted calcium-regulated kinase family implicated in neurological disorders.

DIPK1B DIPK2B

4.14e-05492223840464
Pubmed

Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.

INSIG1 INSIG2

4.14e-05492219740467
InteractionTTYH1 interactions

POMT2 FZD7 PDE3B ABCB9 HTR6 TMEM161B EBP ABCA7 RETREG3 SLC35F5

3.40e-073008110int:TTYH1
InteractionPLPP6 interactions

EBP SLC7A14 VSIR PLPP6 RETREG3

7.35e-0667815int:PLPP6
InteractionCCL4L2 interactions

EBP SLC7A14 VSIR RETREG3

1.02e-0534814int:CCL4L2
Cytoband1p36.21

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.86e-07639251p36.21
Cytoband19q13.33

GPR32 GPR32P1 SLC6A16 TBC1D17

6.42e-0510692419q13.33
CytobandXp11.23-p11.22

CLCN5 EBP

8.29e-057922Xp11.23-p11.22
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF33 PRAMEF10 HTR6 ATAD3A PRAMEF19 PRAMEF17 PRAMEF18

4.52e-04681927chr1p36
CytobandEnsembl 112 genes in cytogenetic band chr12q14

DPY19L2 MARCHF9 WIF1

1.63e-03115923chr12q14
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD1 FZD6 FZD7 FZD5

4.93e-0811654286
GeneFamilyPRAME family

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.53e-0624654686
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK4 GRIK5

1.26e-0456521199
GeneFamilyOpsin receptors

OPN3 OPN5

6.85e-0411652215
GeneFamilyRing finger proteins|Membrane associated ring-CH-type fingers

MARCHF9 MARCHF11

6.85e-041165260
GeneFamilyWD repeat domain containing

PRPF4 FBXW12 CIAO1 WDR77 PHIP

2.50e-03262655362
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SCARB1 CD163

4.22e-03276521253
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS

PRAMEF33 PRAMEF10 PRAMEF19 TCIRG1 PRAMEF17 PRAMEF18 SKAP2

2.75e-06180897MM612
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

5.33e-0634894MM955
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

8.42e-0681895MM938
CoexpressionINGRAM_SHH_TARGETS_UP

GPR155 PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

1.56e-05156896MM550
CoexpressionMORI_SMALL_PRE_BII_LYMPHOCYTE_UP

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18 SKAP2

2.13e-0598895MM592
CoexpressionDESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR

PRAMEF33 PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

2.13e-0598895MM3656
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

PRAMEF10 PRAMEF19 PRAMEF17 PRAMEF18

4.28e-0557894MM1262
CoexpressionGSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_DN

GPR155 IL12B PDE3B HTR6 GRIK5 PHIP

4.59e-05189896M3112
CoexpressionGSE20727_ROS_INH_VS_ROS_INH_AND_DNFB_ALLERGEN_TREATED_DC_DN

FZD1 CELSR2 TNFSF18 RTL3 MUC4 VSIR

5.62e-05196896M9248
CoexpressionGSE26030_TH1_VS_TH17_DAY15_POST_POLARIZATION_UP

GPR155 IL12B GRIK5 ADGRE1 SLC35F5 DUOXA2

6.11e-05199896M8562
CoexpressionGSE5589_UNSTIM_VS_180MIN_LPS_AND_IL10_STIM_MACROPHAGE_UP

FZD1 CLCN5 TAFA3 TCIRG1 ABHD13 SLC35F5

6.29e-05200896M6604
CoexpressionGSE27786_LSK_VS_NKCELL_DN

FZD7 CRNKL1 PDE3B TMEM161B ABCA7 RETREG3

6.29e-05200896M4753
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

PRAMEF33 PRAMEF10 DPY19L2 PRAMEF19 PRAMEF17 PRAMEF18 DPY19L2P2

8.92e-05309897MM1244
CoexpressionKRAS.AMP.LUNG_UP.V1_DN

CRY2 IL12B SLC6A16 GRIK5 ADGRE1

1.25e-04142895M2859
CoexpressionYAMAZAKI_TCEB3_TARGETS_DN

PRAMEF33 PRAMEF10 FZD5 PRAMEF19 PRAMEF17 PRAMEF18

1.42e-04232896MM1019
CoexpressionHALLMARK_NOTCH_SIGNALING

FZD1 FZD7 FZD5

1.75e-0432893M5903
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Neuronal-GABAergic_neurons|GW12 / Sample Type, Dataset, Time_group, and Cell type.

FZD1 P2RY11 FBXW12 OPN3 GRIK4 GABRA1 DIPK2B

1.65e-07195927efdea22118d5be46c5abfe8e3fbe39503390665d
DiseaseLDL cholesterol change measurement

CELSR2 PKD1L3

1.47e-047792EFO_0007804
DiseaseEarly Pregnancy Loss

IL12B LAMA4 MUC4 CD163

2.14e-04109794C3830362
DiseaseMiscarriage

IL12B LAMA4 MUC4 CD163

2.14e-04109794C4552766
DiseaseSpontaneous abortion

IL12B LAMA4 MUC4 CD163

2.14e-04109794C0000786
DiseaseAbortion, Tubal

IL12B LAMA4 MUC4 CD163

2.14e-04109794C0000822
Diseaseeicosapentaenoate EPA; 20:5n3 measurement

FZD1 GRIK5

9.38e-0417792EFO_0021049
Diseaseserum albumin measurement

ABCB9 TCIRG1 OPN5 GRIK5 PKD1L3 ZZEF1 SLC39A13

1.05e-03592797EFO_0004535
Diseasesensorineural hearing loss (implicated_via_orthology)

SCARB1 SLC7A14

1.18e-0319792DOID:10003 (implicated_via_orthology)
Diseaselipoprotein measurement, phospholipid measurement

CELSR2 SCARB1 TRIM31

1.56e-0385793EFO_0004639, EFO_0004732
Diseaseapolipoprotein A 1 measurement

PDE3B CELSR2 ABCB9 SCARB1 PKD1L3 PHIP CD163 SLC39A13

1.95e-03848798EFO_0004614
Diseaseapolipoprotein L1 measurement

HPX PKD1L3

2.04e-0325792EFO_0021854

Protein segments in the cluster

PeptideGeneStartEntry
NFWTIWSGARVLSCS

PRAMEF33

111

A0A0G2JMD5
IALASWSWALCRISL

ABHD13

16

Q7L211
RWVLARGLCLLWTAF

HTR6

91

P50406
FSCGTWLPSRAEWLL

AASDHPPT

21

Q9NRN7
SWISDRLLCSFWQRI

ACER1

186

Q8TDN7
LVWAWSLCRAGAVQT

ATAD3A

106

Q9NVI7
QRASWLAFGVWLLAA

GPR32

156

O75388
CWLSIYDTLIWSFAG

CELSR2

2511

Q9HCU4
CIFLAWLGVFAGSWL

DIPK1B

31

Q5VUD6
WLALLLWVSALSCSF

DIPK2B

16

Q9H7Y0
LSRAVLWLGWFLSCL

ABCA7

586

Q8IZY2
RWGLGSRQLCSFTSW

MUC4

4601

Q99102
AWAVSAAGWVLAALL

P2RY11

146

Q96G91
WAWSGLRCAVLQLAE

KLHL34

611

Q8N239
NFWTIWSGARALSCS

PRAMEF17

111

Q5VTA0
IIGLFANLSSCLWWL

GPR155

666

Q7Z3F1
SSAYIPCRTWWALFS

IL17RE

51

Q8NFR9
LWRSLSLQRWDCSNF

FBXW12

41

Q6X9E4
WAAGAAWLRTLLSVC

PDE3B

101

Q13370
ACWFLPSIIAAAASW

DCSTAMP

51

Q9H295
NFWTIWSGARLLSCS

PRAMEF18

111

Q5VWM3
LTLAALSLGLWWTFD

INSIG1

191

O15503
ICLAAIWAYASFWTT

OPN5

151

Q6U736
GWLCLSLASVWLARR

METTL9

6

Q9H1A3
GLSDCLWAWILLLST

GABRA1

6

P14867
VCLWLSFRSWASGAL

OR2D3

156

Q8NGH3
SAWWCGTIILKFLTS

DPY19L2

431

Q6NUT2
LSSWWAKALFVFCGL

DNAJC5

101

Q9H3Z4
TLAALSIGLWWTFDR

INSIG2

136

Q9Y5U4
YSGRFTCWWLTTIST

IL12B

136

P29460
GSLFLVASISWLIWS

MARCHF9

191

Q86YJ5
RWSLLCQEEGTWFLA

PRSS36

511

Q5K4E3
TFTFVSCLRNGWVWD

OPN3

96

Q9H1Y3
SWLISWGSILAILCA

OTOP1

401

Q7RTM1
LRFSRTWIGIWSVLC

FZD1

316

Q9UP38
TFWIGLWSVLCFIST

FZD5

236

Q13467
TWFLAAGRKWSCEAI

FZD6

306

O60353
WVGVWSVLCCASTLF

FZD7

256

O75084
SATLWVAFCFWLLSN

DUOXA2

181

Q1HG44
AWSSQFRRLTWGCAL

CRNKL1

46

Q9BZJ0
ACFLTRGDLWVSWES

CRY2

381

Q49AN0
SWLIFLDTTLCSAWL

LINC00473

111

A8K010
QRASWLAFGVWLLAA

GPR32P1

156

Q8NGA4
LWGALFIRTNIAWCR

CLCN5

401

P51795
FAFGWSKWNLLCNST

DNAI7

606

Q6TDU7
GASSWLLDGNSWLLC

ATRNL1

31

Q5VV63
GSLFLIASVTWLLWS

MARCHF11

251

A6NNE9
VPLGTWRRLSLCWFA

EBP

56

Q15125
WRRLSLCWFAVCGFI

EBP

61

Q15125
LSTRCVSGVWWAFTL

GRIK4

616

Q16099
STRCVSGVWWAFTLI

GRIK5

616

Q16478
WLFLSSCNGNETSLW

CD163

436

Q86VB7
TLARSFGVEWIASWL

CD48

216

P09326
WGALLSGERLDTWIC

SLC39A13

56

Q96H72
WSFYLGWVSAILLLC

NKG7

131

Q16617
SAWWCGTIILKFLTS

DPY19L2P2

241

Q6ZN68
ASSLSGRCWAGSLWL

WDR77

46

Q9BQA1
LPLWLLWSAACSRAA

LAMA4

11

Q16363
SWPAVGNCSSALRWL

HPX

181

P02790
NCFSGRAGWWFQLLL

RTL3

281

Q8N8U3
FWARIATLAVWAAAA

RXFP4

156

Q8TDU9
ERNWSTGGWLLALCL

TAFA3

6

Q7Z5A8
AALSEWLTAIRAWFC

TRIM31

406

Q9BZY9
LWRFAYLWLNSGGCS

SLC6A16

126

Q9GZN6
SEFLWLWGCFLTSSL

SLC35F5

411

Q8WV83
GWWALLALVTLLSFA

POMT2

56

Q9UKY4
WFWLSLTGVSLAGAL

POMT2

226

Q9UKY4
WWTAACQLLASLFGL

TMEM161A

456

Q9NX61
RGLLSFLTWWIAACL

TMEM161B

456

Q8NDZ6
FLTWWIAACLFSTSL

TMEM161B

461

Q8NDZ6
SSWTLCEGFCWLLLL

TMEFF2

11

Q9UIK5
SFLGFEWQKRWCALS

SKAP2

131

O75563
LATACWSGLCKLWSV

PRPF4

246

O43172
WSIFCAWCSLGFIVA

TMEM178A

256

Q8NBL3
NFWTIWSGARPLSCS

PRAMEF19

111

Q5SWL8
SNGLSKWLTSVCWLL

PKD1L3

1146

Q7Z443
KWLTSVCWLLLGFTS

PKD1L3

1151

Q7Z443
SLACWGKGASDRTLW

SCARB1

481

Q8WTV0
LYCWREAATTWGLST

SPATA31E1

306

Q6ZUB1
CSQLVLASWLAGFLW

OR6T1

141

Q8NGN1
RGWAWTRALLGLCAE

SUPV3L1

301

Q8IYB8
SGSIQWWLLICLAAS

SLC6A18

176

Q96N87
SLGASFLLWWLLSTV

ABCB9

126

Q9NP78
RCWLNTETGFIWSFL

ADGRE1

741

Q14246
DSRCWFLAWNPAGTL

CIAO1

16

O76071
ARSALWCLGLNAAFW

RETREG3

66

Q86VR2
WCLGLNAAFWFFALT

RETREG3

71

Q86VR2
STITWIRFAVWCFVG

SLC7A14

651

Q8TBB6
SGSLCFCFRWLLIWF

TBC1D17

486

Q9HA65
LSSTGADGTICFWLW

PHIP

286

Q8WWQ0
TQGAQRSSWKLWLFC

TNFSF18

16

Q9UNG2
SWRWGSLLFALFLAA

VSIR

11

Q9H7M9
NFWTIWSGARVLSCS

PRAMEF10

111

O60809
AFPAAALWLWSILLC

WIF1

6

Q9Y5W5
WLLGTLYCLCRSDSW

PLPP6

146

Q8IY26
FSLFWSVQGSLLSWC

ZZEF1

961

O43149
KWLCVWAARAASAPS

TCIRG1

591

Q13488