Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransition metal ion binding

LARGE2 ESRRB GATA1 NSD1 LANCL1 APOBEC3A SETDB1 MELTF P3H2 HLTF ZNF638 TNKS PLOD2 D2HGDH ALOX5 ALOX12B ZMYM3 PRNP DNMT1

5.15e-0611899919GO:0046914
GeneOntologyMolecularFunctionp53 binding

HIF1A GATA1 GSK3B SETD7 HDAC1

4.03e-0577995GO:0002039
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

ERCC1 DDX5 SETDB1 HDAC1 DNMT1

5.78e-0583995GO:1990841
GeneOntologyMolecularFunctiontranscription factor binding

MED6 HIF1A ERCC1 ESRRB GATA1 NSD1 GSK3B DDX5 MAPK3 UHRF2 RBFOX2 HDAC1 DNMT1

8.75e-057539913GO:0008134
GeneOntologyMolecularFunctiondioxygenase activity

IDO2 P3H2 PLOD2 ALOX5 ALOX12B

1.28e-0498995GO:0051213
GeneOntologyMolecularFunctionarachidonate 12(S)-lipoxygenase activity

ALOX5 ALOX12B

1.45e-044992GO:0004052
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

HIF1A ESRRB GATA1 NSD1 GSK3B DDX5 MAPK3 UHRF2 RBFOX2 HDAC1 DNMT1

1.45e-045829911GO:0140297
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

HIF1A ESRRB GATA1 NSD1 GSK3B DDX5 UHRF2 HDAC1 DNMT1

2.29e-04417999GO:0061629
GeneOntologyMolecularFunctionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

IDO2 ALOX5 ALOX12B

2.51e-0425993GO:0016702
GeneOntologyMolecularFunctionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen

IDO2 ALOX5 ALOX12B

2.83e-0426993GO:0016701
GeneOntologyBiologicalProcessregulation of telomere capping

ERCC1 TNKS MAPK3 TNKS2

7.73e-0627984GO:1904353
GeneOntologyBiologicalProcesstelomere capping

ERCC1 TNKS MAPK3 TNKS2

4.24e-0541984GO:0016233
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

SOX30 SPIN4 GSK3B AMER2 LRP6 MACF1 TNKS TNKS2 HDAC1

6.47e-05368989GO:0030111
GeneOntologyBiologicalProcesspositive regulation of telomere capping

TNKS MAPK3 TNKS2

6.74e-0517983GO:1904355
GeneOntologyBiologicalProcessregulation of ossification

HIF1A GATA1 SCUBE2 LRP6 MAPK3 ALOX5

7.26e-05147986GO:0030278
DomainLANC-like

LANCL1 LANCL2

8.32e-053992IPR007822
DomainLANC_like

LANCL1 LANCL2

8.32e-053992SM01260
DomainLANC_like

LANCL1 LANCL2

8.32e-053992PF05147
DomainLanC-like_prot_euk

LANCL1 LANCL2

8.32e-053992IPR020464
DomainAbLIM_anchor

ABLIM1 ABLIM2

1.66e-044992PF16182
DomainAbLIM_anchor

ABLIM1 ABLIM2

1.66e-044992IPR032402
DomainEGF-like_dom

FAT2 FCGBP SCUBE2 TENM1 SCUBE3 LRP6 C8B

3.61e-04249997IPR000742
Domain-

DST MACF1

4.11e-0469923.90.1290.10
DomainLipOase_mml

ALOX5 ALOX12B

4.11e-046992IPR001885
DomainLIPOXYGENASE_1

ALOX5 ALOX12B

4.11e-046992PS00711
DomainLipOase_C

ALOX5 ALOX12B

4.11e-046992IPR013819
DomainGAR

DST MACF1

4.11e-046992PS51460
DomainLIPOXYGENASE_2

ALOX5 ALOX12B

4.11e-046992PS00081
DomainLipOase_Fe_BS

ALOX5 ALOX12B

4.11e-046992IPR020833
DomainLipOase_CS

ALOX5 ALOX12B

4.11e-046992IPR020834
DomainGAS2

DST MACF1

4.11e-046992PF02187
DomainLipoxygenase

ALOX5 ALOX12B

4.11e-046992PF00305
DomainLIPOXYGENASE_3

ALOX5 ALOX12B

4.11e-046992PS51393
DomainLipOase

ALOX5 ALOX12B

4.11e-046992IPR000907
Domain-

DST MACF1

4.11e-0469923.30.920.20
DomainGAS_dom

DST MACF1

4.11e-046992IPR003108
DomainGAS2

DST MACF1

4.11e-046992SM00243
DomainPlectin

DST MACF1

5.74e-047992PF00681
DomainPlectin_repeat

DST MACF1

5.74e-047992IPR001101
DomainPLEC

DST MACF1

5.74e-047992SM00250
DomainPHD

BRPF3 NSD1 CHD5 UHRF2

6.77e-0475994PF00628
Domain6hp_glycosidase

LANCL1 LANCL2

7.63e-048992IPR012341
DomainHP

ABLIM1 ABLIM2

7.63e-048992PS51089
Domain-

ABLIM1 ABLIM2

7.63e-0489921.10.950.10
DomainVHP

ABLIM1 ABLIM2

7.63e-048992SM00153
DomainVHP

ABLIM1 ABLIM2

7.63e-048992PF02209
Domain-

LANCL1 LANCL2

7.63e-0489921.50.10.10
DomainVillin_headpiece

ABLIM1 ABLIM2

7.63e-048992IPR003128
DomainZnf_PHD-finger

BRPF3 NSD1 CHD5 UHRF2

8.23e-0479994IPR019787
Domain-

TENM1 LRP6 ROS1

1.15e-03399932.120.10.30
DomainPHD

BRPF3 NSD1 CHD5 UHRF2

1.28e-0389994SM00249
DomainSET

NSD1 SETDB1 SETD7

1.33e-0341993PF00856
DomainZnf_PHD

BRPF3 NSD1 CHD5 UHRF2

1.39e-0391994IPR001965
DomainEphrin_rec_like

SCUBE2 SCUBE3

1.48e-0311992PF07699
DomainBAH

DNMT1 BAHCC1

1.48e-0311992PS51038
DomainBAH_dom

DNMT1 BAHCC1

1.48e-0311992IPR001025
DomainBAH

DNMT1 BAHCC1

1.48e-0311992SM00439
DomainBAH

DNMT1 BAHCC1

1.48e-0311992PF01426
DomainEGF

FAT2 FCGBP SCUBE2 TENM1 SCUBE3 LRP6

1.58e-03235996SM00181
DomainEGF_3

FAT2 SCUBE2 TENM1 SCUBE3 LRP6 C8B

1.58e-03235996PS50026
DomainZF_PHD_2

BRPF3 NSD1 CHD5 UHRF2

1.63e-0395994PS50016
DomainZF_PHD_1

BRPF3 NSD1 CHD5 UHRF2

1.70e-0396994PS01359
DomainEGF_dom

SCUBE2 SCUBE3

1.77e-0312992IPR024731
DomainEGF_3

SCUBE2 SCUBE3

1.77e-0312992PF12947
DomainSET

NSD1 SETDB1 SETD7

1.86e-0346993SM00317
Domain6-blade_b-propeller_TolB-like

TENM1 LRP6 ROS1

1.86e-0346993IPR011042
Domain6-hairpin_glycosidase-like

LANCL1 LANCL2

2.09e-0313992IPR008928
DomainSET_dom

NSD1 SETDB1 SETD7

2.36e-0350993IPR001214
DomainSET

NSD1 SETDB1 SETD7

2.36e-0350993PS50280
DomainEGF_1

FAT2 SCUBE2 TENM1 SCUBE3 LRP6 C8B

2.37e-03255996PS00022
DomainHelicase_C

DDX5 CHD5 HLTF ASCC3

2.53e-03107994PF00271
DomainHELICc

DDX5 CHD5 HLTF ASCC3

2.53e-03107994SM00490
DomainHelicase_C

DDX5 CHD5 HLTF ASCC3

2.61e-03108994IPR001650
DomainEGF-like_CS

FAT2 SCUBE2 TENM1 SCUBE3 LRP6 C8B

2.67e-03261996IPR013032
DomainHELICASE_CTER

DDX5 CHD5 HLTF ASCC3

2.70e-03109994PS51194
DomainHELICASE_ATP_BIND_1

DDX5 CHD5 HLTF ASCC3

2.70e-03109994PS51192
DomainDEXDc

DDX5 CHD5 HLTF ASCC3

2.70e-03109994SM00487
DomainHelicase_ATP-bd

DDX5 CHD5 HLTF ASCC3

2.79e-03110994IPR014001
DomainLY

LRP6 ROS1

2.79e-0315992SM00135
DomainLDLR_classB_rpt

LRP6 ROS1

2.79e-0315992IPR000033
DomainEGF_2

FAT2 SCUBE2 TENM1 SCUBE3 LRP6 C8B

2.87e-03265996PS01186
DomainPost-SET_dom

NSD1 SETDB1

3.18e-0316992IPR003616
DomainDENN

DENND3 DENND4C

3.18e-0316992SM00799
DomainPostSET

NSD1 SETDB1

3.18e-0316992SM00508
DomainP4Hc

P3H2 PLOD2

3.18e-0316992SM00702
DomainDENN

DENND3 DENND4C

3.18e-0316992PF02141
DomaindDENN

DENND3 DENND4C

3.18e-0316992PF03455
DomainUDENN

DENND3 DENND4C

3.18e-0316992PS50946
DomainDDENN

DENND3 DENND4C

3.18e-0316992PS50947
DomaindDENN

DENND3 DENND4C

3.18e-0316992SM00801
DomaindDENN_dom

DENND3 DENND4C

3.18e-0316992IPR005112
DomainuDENN_dom

DENND3 DENND4C

3.18e-0316992IPR005113
DomainDENN

DENND3 DENND4C

3.18e-0316992PS50211
DomainDENN_dom

DENND3 DENND4C

3.18e-0316992IPR001194
DomainPro_4_hyd_alph

P3H2 PLOD2

3.18e-0316992IPR006620
DomainPOST_SET

NSD1 SETDB1

3.18e-0316992PS50868
DomainPoly(ADP-ribose)pol_cat_dom

TNKS TNKS2

3.59e-0317992IPR012317
DomainPARP_CATALYTIC

TNKS TNKS2

3.59e-0317992PS51059
DomainPARP

TNKS TNKS2

3.59e-0317992PF00644
Domain-

TNKS TNKS2

3.59e-03179923.90.228.10
DomainLH2

ALOX5 ALOX12B

4.03e-0318992SM00308
Domain2OG-FeII_Oxy

P3H2 PLOD2

4.48e-0319992PF03171
DomainEGF

FAT2 SCUBE2 SCUBE3 LRP6

4.54e-03126994PF00008
DomainPWWP

BRPF3 NSD1

4.97e-0320992SM00293
DomainZinc_finger_PHD-type_CS

BRPF3 NSD1 CHD5

4.97e-0365993IPR019786
PathwayKEGG_LYSINE_DEGRADATION

NSD1 SETDB1 SETD7 AADAT PLOD2

3.67e-0644765M13720
PathwayREACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING

HIF1A HDAC1 DNMT1

2.41e-0511763M42523
PathwayREACTOME_SIGNALING_BY_WNT_IN_CANCER

GSK3B LRP6 TNKS TNKS2

3.20e-0534764M27405
PathwayKEGG_AXON_GUIDANCE

PAK5 GSK3B ABLIM1 MAPK3 ABLIM2 PLXNA2

6.76e-05129766M5539
PathwayPID_PS1_PATHWAY

GSK3B LRP6 MAPK3 HDAC1

1.07e-0446764M70
Pubmed

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

GSK3B DST LRP6 MACF1

2.01e-081199416815997
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

ERCC1 CARD10 GSK3B TGFBR1 SCUBE2 ABCA6 LRP6 TNKS ROS1 ALOX5

1.45e-07381991018676680
Pubmed

M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.

UHRF2 HDAC1 DNMT1

4.45e-07699322411829
Pubmed

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

GSK3B TNKS TNKS2

4.45e-07699319759537
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

RPN1 LANCL1 LANCL2 GSK3B DDX5 FASN THOP1 ATP6V0D1 DST CLPTM1 MACF1 RAB21 PLOD2 DNAJC3 HDAC1 DNMT1

7.83e-071297991633545068
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RPN1 LANCL2 DENND4C DDX5 ABLIM1 FASN DST LRP6 GIGYF2 MACF1 ASCC3 HDAC1

8.49e-07708991239231216
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

ERCC1 GSK3B TGFBR1 SCUBE2 ABCA6 LRP6 TNKS ROS1 ALOX5

1.29e-0637499919625176
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

ERCC1 GSK3B TGFBR1 SCUBE2 ABCA6 LRP6 TNKS ROS1 ALOX5

1.54e-0638299919170196
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

LARGE2 RPN1 LANCL1 PGAP4 TGFBR1 MELTF PTPRK P3H2 CLPTM1 LRP6 RAB21 PLOD2 DNAJC3 PRNP DNMT1

1.55e-061201991535696571
Pubmed

GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.

GSK3B MAPK3 HDAC1

1.86e-06999315469820
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

IFT140 SETDB1 DST MACF1 PLXNA2 BAHCC1

2.05e-0613099612421765
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GABRG2 RPN1 CORO1C LANCL2 GSK3B DDX5 USP31 ABLIM1 FASN ATP6V0D1 DST STXBP1 MACF1 MAPK3 ABLIM2 PRNP

2.80e-061431991637142655
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

DENND4C SETDB1 FASN DST ANAPC1 GIGYF2 ASCC3 ZMYM3 HDAC1

3.20e-0641899934709266
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

ERCC1 GSK3B TGFBR1 SCUBE2 ABCA6 LRP6 TNKS ROS1 ALOX5

3.39e-0642199919692168
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

RPN1 CORO1C NSD1 ABLIM1 FASN ANAPC1 GIGYF2 ASCC3 HDAC1 DNMT1

3.92e-06549991038280479
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

GSK3B ABLIM1 AMER2 DST STXBP1 GIGYF2 MACF1 ABLIM2

7.05e-0634799817114649
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

HIF1A RPN1 LANCL1 DDX5 KIFAP3 ABLIM1 FASN PTPRK ANAPC1 CLPTM1 TNKS RAB21 ZMYM3 PRNP

7.99e-061203991429180619
Pubmed

Tankyrase is necessary for canonical Wnt signaling during kidney development.

TNKS TNKS2

8.02e-06299220549720
Pubmed

Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review).

HIF1A PRNP

8.02e-06299228901450
Pubmed

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.

TNKS TNKS2

8.02e-06299227494558
Pubmed

A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

DDX5 HDAC1

8.02e-06299220022962
Pubmed

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

HIF1A MAPK3

8.02e-06299210551817
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

DST MACF1

8.02e-06299211002341
Pubmed

The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure.

LANCL1 LANCL2

8.02e-06299236834900
Pubmed

Evaluation of epigenetic-related gene expression (DNMT, HDAC1) in Iranian patients with systemic lupus erythematosus.

HDAC1 DNMT1

8.02e-06299237661113
Pubmed

Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis.

HIF1A FASN

8.02e-06299236604718
Pubmed

HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis.

GATA1 HDAC1

8.02e-06299234450641
Pubmed

SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α.

HIF1A SETD7

8.02e-06299234617577
Pubmed

The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.

MAPK3 PRNP

8.02e-06299221586567
Pubmed

PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer.

HIF1A PLOD2

8.02e-06299229603227
Pubmed

Hypoxia-inducible factor 1-mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions.

HIF1A GATA1

8.02e-06299222050843
Pubmed

Regulation of tankyrase activity by a catalytic domain dimer interface.

TNKS TNKS2

8.02e-06299230055800
Pubmed

Fox-2 protein regulates the alternative splicing of scleroderma-associated lysyl hydroxylase 2 messenger RNA.

PLOD2 RBFOX2

8.02e-06299220131247
Pubmed

Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma.

HIF1A HDAC1

8.02e-06299231704828
Pubmed

Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation.

HDAC1 DNMT1

8.02e-06299217682057
Pubmed

DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.

HDAC1 DNMT1

8.02e-06299216960727
Pubmed

The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.

HIF1A ACO1

8.02e-06299230415773
Pubmed

Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved.

HIF1A ACO1

8.02e-06299221360641
Pubmed

Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis.

HDAC1 DNMT1

8.02e-06299224027299
Pubmed

Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.

TNKS TNKS2

8.02e-06299224291818
Pubmed

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

GATA1 NSD1

8.02e-06299232533074
Pubmed

ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells.

GSK3B MAPK3

8.02e-06299226151480
Pubmed

Hypoxic inactivation of glycogen synthase kinase-3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling.

HIF1A GSK3B

8.02e-06299227365055
Pubmed

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.

TNKS TNKS2

8.02e-06299218612384
Pubmed

Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.

TNKS TNKS2

8.02e-06299228723574
Pubmed

Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.

TNKS TNKS2

8.02e-06299218026951
Pubmed

Novel alterations in IFT172 and KIFAP3 may induce basal cell carcinoma.

IFT172 KIFAP3

8.02e-06299234674729
Pubmed

Structural insights into SAM domain-mediated tankyrase oligomerization.

TNKS TNKS2

8.02e-06299227328430
Pubmed

The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer.

GATA1 SETD7

8.02e-06299226848522
Pubmed

Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma.

HIF1A TGFBR1

8.02e-06299231339433
Pubmed

GSK3β negatively regulates HIF1α mRNA stability via nucleolin in the MG63 osteosarcoma cell line.

HIF1A GSK3B

8.02e-06299224333432
Pubmed

Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.

TNKS TNKS2

8.02e-06299224116873
Pubmed

Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.

HIF1A PFKFB4

8.02e-06299221640852
Pubmed

Hypoxia-inducible factor-1 α regulates prion protein expression to protect against neuron cell damage.

HIF1A PRNP

8.02e-06299222036844
Pubmed

Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.

TNKS TNKS2

8.02e-06299215795250
Pubmed

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.

HIF1A PLOD2

8.02e-06299238472175
Pubmed

A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.

FASN ALOX5

8.02e-06299220126469
Pubmed

The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs.

GATA1 DNMT1

8.02e-06299224021675
Pubmed

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.

SETD7 DNMT1

8.02e-06299219282482
Pubmed

Scube regulates synovial angiogenesis-related signaling.

SCUBE2 SCUBE3

8.02e-06299224084593
Pubmed

Roles of GSK3β in odor habituation and spontaneous neural activity of the mouse olfactory bulb.

GSK3B CNGA2

8.02e-06299223658842
Pubmed

HIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells.

HIF1A PFKFB4

8.02e-06299227181362
Pubmed

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.

TNKS TNKS2

8.02e-06299229263426
Pubmed

NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.

HIF1A NPAS2

8.02e-06299236978001
Pubmed

Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.

HDAC1 DNMT1

8.02e-06299219424621
Pubmed

A human MAP kinase interactome.

IFT140 PAK5 SETDB1 ABLIM1 DST GIGYF2 MACF1 ABLIM2 RBFOX2

1.07e-0548699920936779
Pubmed

High-throughput RNAi screening reveals novel regulators of telomerase.

TNKS MAPK3 TNKS2

1.22e-051699321531765
Pubmed

Comprehensive interactome of Otx2 in the adult mouse neural retina.

ESRRB LANCL2 DDX5 ZNF638

1.62e-055399426426291
Pubmed

Proteomic analysis of in vivo phosphorylated synaptic proteins.

ABLIM1 STXBP1 MAPK3 PLXNA2

1.62e-055399415572359
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ERCC1 IFT172 ACO1 CORO1C SETDB1 ABLIM1 THOP1 DST STXBP1 PTPRK MACF1 TNKS TNKS2 DNMT1

1.67e-051285991435914814
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NSD1 FASN DST ANAPC1 ZNF638 GIGYF2 MACF1 ASCC3 ZMYM3 DNMT1

1.77e-05653991022586326
Pubmed

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.

SETDB1 HDAC1 DNMT1

1.77e-051899324025402
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CORO1C PAK5 NSD1 GSK3B ABLIM1 DST ANAPC1 GIGYF2 MACF1 TNKS MAPK3 DNMT1

1.92e-05963991228671696
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

HIF1A ESRRB GATA1 ABLIM1 HLTF ZNF638 ABLIM2 UHRF2 PLXNA2 DNMT1 NPAS2

1.96e-05808991120412781
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

RPN1 CORO1C DDX5 ABLIM1 FASN DST ANAPC1 MAPK3

2.00e-0540199825852190
Pubmed

Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex.

GSK3B LRP6 MAPK3

2.10e-051999334431536
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

IFT172 USP31 SETDB1 ABLIM1 GIGYF2 MACF1 PLXNA2 ZMYM3

2.22e-0540799812693553
Pubmed

Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation.

MAPK3 DNMT1

2.40e-05399220212170
Pubmed

Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.

TNKS TNKS2

2.40e-05399232442396
Pubmed

De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1.

GSK3B MAPK3

2.40e-05399217273789
Pubmed

Regulation of the HIF-1alpha stability by histone deacetylases.

HIF1A HDAC1

2.40e-05399217273746
Pubmed

SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

DDX5 HDAC1

2.40e-05399217369852
Pubmed

Expression of the mouse Macf2 gene during inner ear development.

DST MACF1

2.40e-05399212399109
Pubmed

Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells.

HDAC1 DNMT1

2.40e-05399228102109
Pubmed

The histone deacetylase HDAC1 activates HIF1α/VEGFA signal pathway in colorectal cancer.

HIF1A HDAC1

2.40e-05399232525044
Pubmed

Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.

SCUBE2 SCUBE3

2.40e-05399212270931
Pubmed

Derepression of the DNA Methylation Machinery of the Gata1 Gene Triggers the Differentiation Cue for Erythropoiesis.

GATA1 DNMT1

2.40e-05399228069743
Pubmed

Functional regulation of hypoxia inducible factor-1α by SET9 lysine methyltransferase.

HIF1A SETD7

2.40e-05399225637186
Pubmed

Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.

HIF1A FASN

2.40e-05399226951539
Pubmed

Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells.

TGFBR1 HDAC1

2.40e-05399215155736
Pubmed

LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome.

LANCL1 LANCL2

2.40e-05399233932340
Pubmed

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.

SETD7 DNMT1

2.40e-05399221151116
Pubmed

Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes.

HDAC1 DNMT1

2.40e-05399223548937
Pubmed

Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma.

HIF1A FASN

2.40e-05399230914315
Pubmed

A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.

GSK3B MAPK3

2.40e-05399229136244
Pubmed

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation.

SETD7 DNMT1

2.40e-05399219098913
Pubmed

MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia.

HIF1A GATA1

2.40e-05399227485543
Pubmed

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.

TNKS TNKS2

2.40e-05399211739745
Pubmed

Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells.

GSK3B MAPK3

2.40e-05399218263590
Pubmed

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

TNKS TNKS2

2.40e-05399225939383
InteractionAPC interactions

EPB41L4A GSK3B KIFAP3 SETDB1 DST GIGYF2 MACF1 TNKS PRNP RBFOX2 HDAC1 DNMT1

4.61e-073899912int:APC
InteractionSP1 interactions

HIF1A ESRRB GATA1 GSK3B DDX5 FASN HLTF MAPK3 DNAJC3 HDAC1 DNMT1

1.80e-063659911int:SP1
InteractionCAMSAP2 interactions

DENND4C GSK3B DDX5 ZNF638 GIGYF2 MACF1 SETD7 DNAJC3

1.85e-06169998int:CAMSAP2
InteractionZFPM1 interactions

ESRRB GATA1 GSK3B HDAC1

3.74e-0622994int:ZFPM1
InteractionESRRA interactions

BRPF3 HIF1A ESRRB NSD1 MACF1

1.96e-0567995int:ESRRA
InteractionHDAC1 interactions

HIF1A ESRRB GATA1 DENND4C DDX5 SETDB1 FASN DST CHD5 ZNF638 GIGYF2 ASCC3 UHRF2 ZMYM3 HDAC1 DNMT1 BAHCC1

2.60e-0511089917int:HDAC1
InteractionRCOR1 interactions

ESRRB DENND4C FASN DST ANAPC1 GIGYF2 ASCC3 UHRF2 ZMYM3 PRNP HDAC1

3.10e-054949911int:RCOR1
InteractionIQGAP1 interactions

HIF1A CORO1C PAK5 GSK3B DDX5 ABLIM1 DST LRP6 MAPK3 ASCC3 PRNP HDAC1

3.27e-055919912int:IQGAP1
InteractionUSP7 interactions

HIF1A PAK5 GATA1 NSD1 EPB41L4A SPIN4 GSK3B DDX5 FAT2 DST HLTF ZNF638 GIGYF2 MACF1 UHRF2 PRNP HDAC1 DNMT1

6.42e-0513139918int:USP7
InteractionSYNE3 interactions

RPN1 CARD10 GSK3B ABLIM1 DST ANAPC1 MACF1 PLOD2 DNAJC3 PRNP

6.60e-054449910int:SYNE3
InteractionHDAC4 interactions

HIF1A IFT172 GATA1 DENND4C GSK3B DDX5 THOP1 ZNF638 GIGYF2 TNKS MAPK3 DNAJC3 DNMT1

7.07e-057449913int:HDAC4
GeneFamilyArachidonate lipoxygenases

ALOX5 ALOX12B

2.26e-046712407
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD1 SETDB1 SETD7

3.18e-0434713487
GeneFamilyTudor domain containing

SPIN4 SETDB1 UHRF2

4.10e-0437713780
GeneFamilyEF-hand domain containing|Plakins

DST MACF1

4.19e-048712939
GeneFamilyPHD finger proteins

BRPF3 NSD1 CHD5 UHRF2

4.32e-049071488
GeneFamilyPHD finger proteins|NuRD complex

CHD5 HDAC1

9.78e-04127121305
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

TNKS TNKS2

1.99e-0317712684
GeneFamilyPWWP domain containing

BRPF3 NSD1

3.34e-03227121147
GeneFamilyIntraflagellar transport proteins|Tetratricopeptide repeat domain containing

IFT140 IFT172

3.97e-0324712615
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND3 DENND4C

4.30e-0325712504
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

HIF1A GSK3B KIFAP3 SETDB1 DST PTPRK HLTF ZNF638 GIGYF2 MACF1 TNKS ASCC3 RAB21 PLOD2 RBFOX2

6.65e-078569815M4500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

ARHGAP42 TGFBR1 USP31 SETDB1 ANGPTL2 ANAPC1 GIGYF2 TNKS TNKS2 PLXNA2 RBFOX2

2.08e-073129811gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500

ARHGAP42 TGFBR1 USP31 GIGYF2 TNKS TNKS2 PLXNA2 RBFOX2

4.49e-07149988gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

TGFBR1 USP31 ANGPTL2 PTPRK ANAPC1 TNKS ASCC3 TNKS2 DNAJC3 PLXNA2 RBFOX2

1.65e-063859811gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_1000

HIF1A NSD1 GSK3B TGFBR1 USP31 SETDB1 ANGPTL2 ANAPC1 ASCC3 TNKS2 RBFOX2

2.22e-063979811gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_k-means-cluster#1_top-relative-expression-ranked_1000

TGFBR1 USP31 TNKS TNKS2 PLXNA2 RBFOX2

7.37e-06101986gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#5_top-relative-expression-ranked_500

NSD1 TGFBR1 USP31 SETDB1 ASCC3 TNKS2 RBFOX2

1.15e-05165987DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k5_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#1_top-relative-expression-ranked_500

NSD1 GSK3B TGFBR1 USP31 SETDB1 ASCC3 TNKS2 RBFOX2

1.18e-05231988gudmap_developingLowerUrinaryTract_e14.5_ bladder_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#5_top-relative-expression-ranked_200

TGFBR1 USP31 ANGPTL2 TNKS2 RBFOX2

1.68e-0569985gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_200_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

HIF1A NSD1 GSK3B TGFBR1 USP31 SETDB1 ASCC3 TNKS2 RBFOX2

2.22e-05330989DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_200

NSD1 GSK3B TGFBR1 TNKS2 RBFOX2

3.05e-0578985gudmap_developingLowerUrinaryTract_e14.5_ bladder_200_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500

TGFBR1 USP31 ANGPTL2 ANAPC1 TNKS2 PLXNA2 RBFOX2

5.25e-05209987gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

GSK3B TGFBR1 USP31 GIGYF2 TNKS TNKS2 RBFOX2

5.25e-05209987gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_500

ARHGAP42 TGFBR1 TENM1 HLTF SCUBE3 GIGYF2 ASCC3 TNKS2 RBFOX2

8.09e-05390989gudmap_developingKidney_e15.5_cortic collect duct_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000

NSD1 LANCL1 TGFBR1 USP31 SETDB1 DST GIGYF2 TNKS ASCC3 TNKS2 CRISPLD1 PLXNA2 RBFOX2

8.44e-058069813DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

ARHGAP42 LANCL1 TGFBR1 USP31 SETDB1 DST ANGPTL2 ANAPC1 GIGYF2 TNKS TNKS2 PLXNA2 RBFOX2

8.44e-058069813gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_200

TGFBR1 TENM1 HLTF SCUBE3 GIGYF2 TNKS2

8.61e-05156986gudmap_developingKidney_e15.5_cortic collect duct_200
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500

ARHGAP42 TGFBR1 GIGYF2 ASCC3 TNKS2 RBFOX2

1.10e-04163986gudmap_developingKidney_e15.5_cortic collect duct_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500

ARHGAP42 TGFBR1 USP31 DST GIGYF2 TNKS TNKS2 PLXNA2 RBFOX2

1.12e-04407989gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#1_top-relative-expression-ranked_200

TGFBR1 USP31 SETDB1 RBFOX2

1.82e-0461984DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k1_200
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000

ARHGAP42 LARGE2 TGFBR1 TENM1 HLTF SCUBE3 GIGYF2 ROS1 ASCC3 TNKS2 DNAJC3 RBFOX2

2.32e-047749812gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#3_top-relative-expression-ranked_500

TGFBR1 GIGYF2 TNKS2 AADAT RBFOX2

2.56e-04122985gudmap_developingLowerUrinaryTract_e15.5_Urothelium_500_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_500

NSD1 TGFBR1 USP31 SETDB1 TNKS2 RBFOX2

2.82e-04194986DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_500
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000

ARHGAP42 NSD1 TGFBR1 DST HLTF SCUBE3 GIGYF2 TNKS ASCC3 TNKS2 DNAJC3 RBFOX2

2.96e-047959812gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

NSD1 TGFBR1 USP31 SETDB1 TNKS ASCC3 TNKS2 RBFOX2

3.11e-04369988DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_500

ARHGAP42 TGFBR1 GIGYF2 TNKS2 DNAJC3 RBFOX2

3.41e-04201986gudmap_developingKidney_e15.5_500_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_1000

HIF1A NSD1 GSK3B TGFBR1 USP31 SETDB1 ANGPTL2 ANAPC1 GIGYF2 ASCC3 TNKS2 RBFOX2

3.55e-048119812gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_1000

TGFBR1 SETDB1 ANAPC1 TNKS2 DNAJC3 RBFOX2

3.60e-04203986gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_200

TGFBR1 USP31 SETDB1 RBFOX2

4.03e-0475984DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#3_top-relative-expression-ranked_100

NSD1 TGFBR1 RBFOX2

5.14e-0434983gudmap_developingLowerUrinaryTract_e14.5_ bladder_100_k3
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000

TGFBR1 USP31 TNKS TNKS2 RBFOX2

5.83e-04146985gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_500

NSD1 TGFBR1 USP31 SETDB1 DST GIGYF2 TNKS2 RBFOX2

6.05e-04408988DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_500
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29965_k-means-cluster#5_top-relative-expression-ranked_1000

TGFBR1 USP31 HLTF TNKS2

6.20e-0484984gudmap_developingKidney_e15.5_Endothelial cells_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_top-relative-expression-ranked_500

CARD10 TGFBR1 USP31 ANAPC1 P3H2 TNKS TNKS2 DNAJC3

6.66e-04414988gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_500

NSD1 GSK3B TGFBR1 USP31 SETDB1 ASCC3 TNKS2 RBFOX2

7.42e-04421988gudmap_developingLowerUrinaryTract_e14.5_ bladder_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_500

USP31 GIGYF2 TNKS2 RBFOX2

7.71e-0489984gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#4_top-relative-expression-ranked_1000

SPIN4 TGFBR1 USP31 RBFOX2

8.04e-0490984gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500

NSD1 TGFBR1 USP31 SETDB1 TENM1 ASCC3 TNKS2 RBFOX2

8.14e-04427988DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#4_top-relative-expression-ranked_200

TGFBR1 GIGYF2 RBFOX2

8.32e-0440983gudmap_developingKidney_e15.5_Ureteral Smooth Musc_200_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

GSK3B TGFBR1 USP31 DST TENM1 HLTF GIGYF2 TNKS TNKS2 CRISPLD1 RBFOX2

8.36e-047699811gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#3

ERCC1 SPIN4 TGFBR1 USP31 SETDB1 ATP6V0D1 LRP6 TNKS FAM118B

8.93e-04541989Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K3
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_1000

IFT172 LANCL1 TGFBR1 USP31 HLTF SCUBE3 TNKS TNKS2 UHRF2 CRISPLD1 RBFOX2

9.28e-047799811gudmap_developingKidney_e15.5_Cap mesenchyme_1000
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 AMER2 ATP6V0D1 STXBP1 PRNP RBFOX2

1.60e-0820099844bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

HIF1A CORO1C MACF1 ABLIM2 ALOX5 PLXNA2 NPAS2

2.47e-071929978b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD1 DDX5 DST STXBP1 MACF1 ASCC3 TNKS2

2.74e-071959973e519cffa6144a62b06124642a14c9ff39b76554
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 AMER2 STXBP1 CES4A RBFOX2

3.04e-07198997d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 DDX5 KIFAP3 AMER2 STXBP1 RBFOX2

3.14e-07199997b2508bf591720830e8e3494b1337aab14539956d
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 AMER2 ATP6V0D1 STXBP1 RBFOX2

3.25e-07200997e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 ABLIM2 RBFOX2

3.25e-0720099748d801219bc771d6c7e151dc88ca4c179988de85
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 AMER2 ATP6V0D1 STXBP1 RBFOX2

3.25e-0720099709fd3cb31bcc02444f1045f01fe39bce09359d35
ToppCelllung-Type_II_Pneumocytes|lung / shred on tissue and cell subclass

FASN STXBP1 P3H2 ROS1 AADAT PLXNA2

9.58e-071479968a3039de45b8087f8319e2e37329acf7278219b7
ToppCellCTRL-Myeloid-Alveolar_Macrophage|Myeloid / Disease state, Lineage and Cell class

ACO1 EPB41L4A JAML DENND4C DST ALOX5

4.64e-0619399680871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCellMacrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

CORO1C GMFG JAML DENND4C DST ALOX5

4.78e-0619499654fda501ce1d041285d04c3c96c15983f454bed4
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EPB41L4A DST STXBP1 PTPRK MACF1 RBFOX2

4.78e-061949960b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 GMFG JAML ATP6V0D1 C8B ALOX5

4.78e-06194996412c2b8eb522da6c84f8b00d32d6f0bee555251f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.07e-06196996676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 GMFG JAML ATP6V0D1 C8B ALOX5

5.07e-06196996eb7d6bbfb766cdeaf5fe0f0bb66a5f491fd5ef26
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 GMFG JAML ATP6V0D1 C8B ALOX5

5.07e-061969962793ad692d49b3ee78a5cd2d8e0220bf5188a686
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 GMFG JAML ATP6V0D1 C8B ALOX5

5.07e-06196996aae79eafe5bc2c7de16958994a2fe97439d7bea1
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 GMFG JAML ATP6V0D1 C8B ALOX5

5.22e-061979964f022bae7af2ca23689cc0d35046a7e23dba6e9c
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

LARGE2 CACNA1F PFKFB4 FASN P3H2 NIM1K

5.22e-061979961a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 GMFG JAML ATP6V0D1 C8B ALOX5

5.22e-0619799669671ed173057a67265ac39ed03fbd57dbd22c5c
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.37e-06198996c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.37e-061989966d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.37e-061989968ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellTracheal-10x5prime-Stromal-Chondrocytic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GABRG2 ANGPTL2 SCUBE2 P3H2 SCUBE3 CRISPLD1

5.37e-06198996c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.37e-061989964ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellTracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GABRG2 ANGPTL2 SCUBE2 P3H2 SCUBE3 CRISPLD1

5.37e-0619899655f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.37e-061989960ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-Neurons|GW10 / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 AMER2 STXBP1 RBFOX2

5.53e-061999960c5a5fbb174a013be10961f0db65c65c797ab4af
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

PAK5 KIFAP3 ABLIM1 DST CHD5 RBFOX2

5.53e-061999961b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 STXBP1 CHD5 RBFOX2

5.53e-061999965de2a32bc2e9c752eb19a013b1807949153728fc
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

PAK5 KIFAP3 ABLIM1 DST CHD5 RBFOX2

5.53e-061999964bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

PAK5 KIFAP3 STXBP1 CHD5 PLXNA2 RBFOX2

5.53e-0619999677b4aa00f14b86ef5db0490be98787e063979541
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PAK5 KIFAP3 AMER2 STXBP1 PLXNA2 RBFOX2

5.69e-0620099684e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PAK5 KIFAP3 AMER2 STXBP1 PLXNA2 RBFOX2

5.69e-062009961decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-Neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

GABRG2 PAK5 KIFAP3 AMER2 STXBP1 RBFOX2

5.69e-06200996ddac952ad1d46021c2d17d816de9bc31730a0941
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 EPB41L4A MELTF CHD5 PLXNA2

2.67e-051579956ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellfacs-BAT-Fat-18m-Myeloid-granulocyte|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMFG PFKFB4 JAML DENND3 ALOX5

3.79e-05169995d3e6c75e5eda133fb6535cfe6c6a1026641f26ac
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MELTF NIM1K SCUBE3 CES4A CRISPLD1

4.01e-05171995d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACO1 CORO1C DENND4C C8B ALOX5

4.12e-05172995c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ESRRB FCGBP ABCA6 SCUBE3 LRP6

4.24e-051739950c74bdb40e635d906fd180412c23bf7fed61621e
ToppCellSevere-B_naive-8|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

LARGE2 VPREB3 DDX5 ALOX5 BAHCC1

4.35e-05174995f3f8c924420f46321bd47e2b97f18c7241541599
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD1 ZNF638 MACF1 TNKS ASCC3

4.60e-05176995749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 CARD10 MELTF TENM1 SCUBE3

4.60e-0517699595d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

NSD1 DCDC2B MELTF DST TNKS

4.72e-0517799582fdd6185b368f54f03de389427cbe3071d21a99
ToppCellfacs-Brain_Myeloid-Striatum|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A RPN1 TGFBR1 CRYBB1 MACF1

4.72e-05177995efb1990fd1d216f64261e81017299783afb24a1e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 CARD10 MELTF TENM1 SCUBE3

4.98e-051799953b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

JAML FCGBP P3H2 CLPTM1 ALOX5

5.12e-05180995289f8c4b53ffd164fee1f459a9315c0deb5f76d0
ToppCellsystemic_lupus_erythematosus-treated-Hematopoietic-progenitor_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GATA1 PGAP4 PLOD2 CRISPLD1 RBFOX2

5.12e-051809952694f5deaed551c53e74d8a9fbd41d3734bb9f37
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

FASN PTPRK P3H2 NIM1K ROS1

5.12e-05180995198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellsystemic_lupus_erythematosus-treated-Hematopoietic-progenitor_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GATA1 PGAP4 PLOD2 CRISPLD1 RBFOX2

5.12e-05180995ef0de602fc8ccfd32a06978ac0100afe0ce1beeb
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

5.39e-051829956497eeafb2b137e70261ec0314782831892a940d
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

5.39e-05182995d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

5.39e-05182995bd1626261803324084fafca2f6665b50854e7fae
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

5.39e-051829952a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

5.39e-05182995918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

5.39e-051829950d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCellBasal|World / shred by cell class for mouse tongue

LARGE2 CARD10 DST P3H2 PLXNA2

5.53e-05183995c6729a207526ff4aa48176207b9353176f631fea
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HIF1A EPB41L4A USP31 ASCC3 PLXNA2

5.68e-05184995c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LANCL1 ABLIM1 FASN TENM1 ZNF638

5.68e-05184995bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD1 VPREB3 ZNF638 MACF1 ASCC3

5.68e-051849951154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellCOPD-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

ACO1 DENND4C DST C8B ALOX5

5.68e-051849957fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCellIPF-Myeloid-DC_Langerhans|IPF / Disease state, Lineage and Cell class

JAML TAMALIN IDO2 FCGBP P3H2

5.82e-05185995f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-B_cells-Pro-B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LARGE2 GMFG VPREB3 DENND3 ALOX5

5.98e-051869954a5264e32ba004ed58dc4102d84e4bc4dbbe1440
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-B_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LARGE2 GMFG VPREB3 DENND3 ALOX5

5.98e-05186995528ee88f6e27863c7bcdffd4416cbbd83fc65e9d
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MELTF FCGBP ABCA6 PRPF40B MAPK3

6.13e-0518799559d28f4ee1d463ae20abb8d7e7399b504d80698a
ToppCellControl-Myeloid-MoAM5|Control / Disease group,lineage and cell class (2021.01.30)

MELTF FCGBP ABCA6 PRPF40B MAPK3

6.13e-051879958769341be67382cea2a590d962f4def7c39de883
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MELTF FCGBP ABCA6 PRPF40B MAPK3

6.13e-0518799525adf648c05c21534b4913254e73d43fc5f64e06
ToppCellBAL-Control-Myeloid-MoAM-MoAM5|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MELTF FCGBP ABCA6 PRPF40B MAPK3

6.13e-051879953b0cfa9e5ea5e7d6dda689c328b9b5110b43ee1d
ToppCellBAL-Control-Myeloid-MoAM-MoAM5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MELTF FCGBP ABCA6 PRPF40B MAPK3

6.13e-051879950d589de12108230ced5b60229564f4a181e2f172
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EPB41L4A DENND3 ABLIM1 P3H2 PLXNA2

6.29e-05188995eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellnormal-na-Hematopoietic-progenitor_cell|normal / PBMC cell types (v2) per disease, treatment status, and sex

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

6.29e-05188995013162466a3334b6967c0cb670c8577d809b1396
ToppCellnormal-na-Hematopoietic-progenitor_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

6.29e-05188995be25371e6459504b5f0c9ece3a0fe8f80c7824ca
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GMFG GATA1 JAML IDO2 ALOX5

6.44e-051899958419d62e6991851bdc6ad861f5c9086ff808b222
ToppCellControl-Myeloid-Macrophage_Alveolar|Control / Disease state, Lineage and Cell class

ACO1 EPB41L4A DENND4C DST ALOX5

6.44e-05189995937e876122bc4b94372a4104e9c1a9068c232018
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-dendritic_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

JAML TAMALIN FCGBP P3H2 DNMT1

6.44e-05189995e97c64609b1f8158d750edb869df56e5bd10538b
ToppCellHealthy-HSPC|Healthy / disease group, cell group and cell class

GATA1 PGAP4 AADAT PLOD2 CRISPLD1

6.44e-05189995214b225effc40ca1b83dd8052f2a7b80b65d4938
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACO1 JAML DST C8B ALOX5

6.61e-051909950eef5a8bd88ef8a25a67d9dd522d9472fa4b3d2f
ToppCellCOPD-Myeloid-Macrophage_Alveolar|COPD / Disease state, Lineage and Cell class

ACO1 CORO1C DENND4C DST ALOX5

6.61e-05190995006e31606d637033bc81333816ee332773d36b08
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PFKFB4 JAML DENND3 APOBEC3A ALOX5

6.61e-05190995ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LARGE2 VPREB3 TAMALIN PTPRK ALOX5

6.61e-0519099560bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ACO1 JAML DST C8B ALOX5

6.61e-051909952724e8f375d8d9f5f2a77444e0491af264babac5
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

ACO1 EPB41L4A JAML DST ALOX5

6.61e-051909952592765016f291565697265800a232b2edef3792
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

ACO1 CORO1C EPB41L4A DENND4C DST

6.61e-051909959fc763d65470ba8858b973689c4d4358faab7dd3
ToppCell3'_v3-Lung-Myeloid_Dendritic-DC2|Lung / Manually curated celltypes from each tissue

JAML TAMALIN FCGBP ABCA6 P3H2

6.61e-05190995468525c05e38158a3b8a445882b2d63dfb1d2c63
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_2|343B / Donor, Lineage, Cell class and subclass (all cells)

ACO1 CORO1C JAML C8B ALOX5

6.61e-051909956514f00d222eef08c282face7f177259bca62f0e
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ACO1 JAML DST C8B ALOX5

6.61e-0519099511fbd4e9f02750354b3aadf30edc991f8d4f8f41
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACO1 JAML DST C8B ALOX5

6.61e-05190995148d43dd72e2e22b2cd68e17fedae6bd98b32aee
ToppCellSevere_COVID-19-Myeloid-TRAM1|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ACO1 JAML DST C8B ALOX5

6.77e-05191995bd641aab36276dd952a7265ee79ba455b38d8e6b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HIF1A ESRRB ABLIM1 P3H2 PLOD2

6.77e-051919952fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ACO1 JAML DST C8B ALOX5

6.77e-051919952b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ACO1 JAML DST C8B ALOX5

6.77e-0519199502e1ae144da7274171e055356d10e8d175c5347f
ToppCellSevere_COVID-19-Myeloid-TRAM3|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ACO1 JAML DST C8B ALOX5

6.77e-0519199505867b96199a46a415848409130697c810d18937
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ACO1 JAML DST C8B ALOX5

6.77e-051919954c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PAK5 TAMALIN DST MAPK3 CRISPLD1

6.77e-05191995d162917816dd2e4767c97447c1cddae9397713ab
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACO1 JAML DST C8B ALOX5

6.77e-05191995de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-OPC_related-OPC|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ARHGAP42 LARGE2 ANGPTL2 SCUBE2 PLOD2

6.94e-051929955d9bc234f01c73b2531edf8960588d5b6cf260a7
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_A_+_HSC|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA1 PGAP4 DST CRISPLD1 BAHCC1

6.94e-05192995959c28d28397bc0b9d3970d1fe3293d2750e63d4
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACO1 JAML DST C8B ALOX5

6.94e-0519299534505a13b8a47c9286c560122fa7861b9c331a08
ToppCellCOVID-19-Myeloid-TRAM1|COVID-19 / Condition, Lineage and Cell class

ACO1 JAML DST C8B ALOX5

6.94e-0519299552b8578699325b0d35a2d3ba36772096130ccc0c
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACO1 JAML DST C8B ALOX5

6.94e-0519299557c1410ebf90c230993e065eb78385daa3360960
DrugFelodipine [72509-76-3]; Down 200; 10.4uM; HL60; HT_HG-U133A

MED6 NSD1 LANCL1 DENND4C CLPTM1 LRP6 PLOD2 BAHCC1

2.12e-061949982433_DN
DiseaseProstatic Neoplasms

HIF1A GSK3B SETDB1 PTPRK MAPK3 DNAJC3 ALOX5 ALOX12B ZMYM3 PRNP DNMT1

5.89e-066169711C0033578
DiseaseMalignant neoplasm of prostate

HIF1A GSK3B SETDB1 PTPRK MAPK3 DNAJC3 ALOX5 ALOX12B ZMYM3 PRNP DNMT1

5.89e-066169711C0376358
DiseaseMainzer-Saldino Disease

IFT140 IFT172

1.07e-052972C1849437
DiseaseCongenital anosmia

TENM1 CNGA2

1.07e-052972C0393778
Diseaseschizophrenia (is_marker_for)

GSK3B SETDB1 MAPK3 DNMT1

1.35e-0544974DOID:5419 (is_marker_for)
DiseaseAdenocarcinoma of lung (disorder)

ERCC1 PAK5 FASN ROS1 ALOX5 ALOX12B

6.27e-05206976C0152013
Diseaselung carcinoma (implicated_via_orthology)

ERCC1 DNMT1

1.06e-045972DOID:3905 (implicated_via_orthology)
DiseaseCEROID LIPOFUSCINOSIS, NEURONAL, 6

GSK3B MAPK3

1.59e-046972C1866282
Diseasemyelofibrosis (is_marker_for)

ERCC1 GATA1

1.59e-046972DOID:4971 (is_marker_for)
Diseasemelanoma

ERCC1 SETDB1 MELTF FASN PTPRK ROS1

1.73e-04248976C0025202
Diseasecolorectal cancer (is_marker_for)

HIF1A ERCC1 GATA1 FASN HDAC1

1.74e-04157975DOID:9256 (is_marker_for)
DiseaseMood Disorders

HIF1A GSK3B PRNP HDAC1 DNMT1

2.38e-04168975C0525045
DiseaseNeoplasm Invasiveness

HIF1A ACO1 MAPK3 ALOX5 DNMT1

3.62e-04184975C0027626
DiseaseCreutzfeldt Jacob Disease

PRNP NPAS2

3.79e-049972EFO_0004226
DiseaseHereditary Diffuse Gastric Cancer

ERCC1 FCGBP MAPK3 ALOX5 PRNP DNMT1

4.22e-04293976C1708349
Diseasemiddle cerebral artery infarction (implicated_via_orthology)

HIF1A GSK3B MAPK3

4.42e-0445973DOID:3525 (implicated_via_orthology)
DiseaseStomach Neoplasms

ERCC1 FCGBP MAPK3 ALOX5 PRNP DNMT1

4.54e-04297976C0038356
Diseasealopecia areata (is_marker_for)

HDAC1 DNMT1

4.73e-0410972DOID:986 (is_marker_for)
DiseaseMalignant neoplasm of stomach

ERCC1 FCGBP MAPK3 ALOX5 PRNP DNMT1

4.78e-04300976C0024623
Diseaseacute myeloid leukemia (is_marker_for)

ERCC1 GATA1 DNMT1

5.69e-0449973DOID:9119 (is_marker_for)
DiseaseJeune thoracic dystrophy

IFT140 IFT172

5.77e-0411972C0265275
DiseaseSchizophrenia

GABRG2 CACNA1F GSK3B SETDB1 STXBP1 MAPK3 PLXNA2 HDAC1 DNMT1 NPAS2

6.58e-048839710C0036341
Diseasesalicylurate measurement

ABLIM1 ZNF638

8.15e-0413972EFO_0010532
DiseaseShort Rib-Polydactyly Syndrome

IFT140 IFT172

8.15e-0413972C0036996
DiseaseInfantile Severe Myoclonic Epilepsy

GABRG2 STXBP1

8.15e-0413972C0751122
DiseaseSaldino-Noonan Syndrome

IFT140 IFT172

9.49e-0414972C0036069
DiseaseMajewski Syndrome

IFT140 IFT172

9.49e-0414972C0024507
DiseaseTesticular Germ Cell Tumor

ALOX5 ALOX12B

9.49e-0414972C1336708
Diseaseovarian neoplasm

FASN MAPK3 ALOX5 ALOX12B

1.02e-03134974C0919267
Diseasehepatic encephalopathy (biomarker_via_orthology)

GABRG2 HIF1A

1.09e-0315972DOID:13413 (biomarker_via_orthology)
DiseaseMalignant neoplasm of ovary

FASN MAPK3 ALOX5 ALOX12B

1.10e-03137974C1140680
Diseaserespiratory system disease

TGFBR1 PTPRK SCUBE3 D2HGDH

1.36e-03145974EFO_0000684
DiseaseDementia

PRNP DNMT1

1.41e-0317972C0497327
DiseaseBenign Neoplasm

ERCC1 APOBEC3A FASN

1.48e-0368973C0086692
DiseaseNeoplasms

ERCC1 APOBEC3A FASN

1.48e-0368973C0027651
DiseasePancreatic carcinoma

ALOX5 ALOX12B

1.76e-0319972C0235974
DiseaseNon-Small Cell Lung Carcinoma

HIF1A ERCC1 CORO1C ROS1

1.78e-03156974C0007131
Diseasealkaline phosphatase measurement

PGAP4 GSK3B ABCA6 CLPTM1 SCUBE3 MACF1 TNKS TNKS2 FAM118B DNMT1

1.87e-0310159710EFO_0004533
Diseasecancer (implicated_via_orthology)

ESRRB DDX5 DST MACF1 MAPK3

1.94e-03268975DOID:162 (implicated_via_orthology)
Diseasecorneal hysteresis

ABCA6 ANAPC1

1.96e-0320972EFO_0010066
Diseaseage of onset of asthma

SCUBE3 D2HGDH NPAS2

2.27e-0379973OBA_2001001
DiseaseFEV/FEC ratio

ARHGAP42 SOX30 NSD1 DENND3 DDX5 FCGBP DST ANAPC1 SCUBE3 MAPK3 D2HGDH

2.34e-0312289711EFO_0004713
Diseasepulmonary hypertension (biomarker_via_orthology)

HIF1A ALOX5 HDAC1

2.36e-0380973DOID:6432 (biomarker_via_orthology)
DiseaseHodgkins lymphoma

FCGBP PTPRK MAPK3

2.53e-0382973EFO_0000183
DiseaseQRS duration, response to sulfonylurea

LANCL2 ZNF638

2.59e-0323972EFO_0005055, EFO_0007922
DiseaseMalignant neoplasm of breast

HIF1A PFKFB4 APOBEC3A FASN P3H2 CHD5 TENM1 MACF1 CNGA2 DNMT1

2.81e-0310749710C0006142

Protein segments in the cluster

PeptideGeneStartEntry
ARVVFDQDGYYYPDS

ACO1

186

P21399
RKYDFLIIEDDPYYF

AADAT

221

Q8N5Z0
DRQDLYYLAGTYDPT

BAHCC1

2611

Q9P281
PRDSYSGDALYDLYA

AMER2

546

Q8N7J2
RGYEAFLEALEFYYP

CARD10

91

Q9BWT7
LEDFLEYEGYKYERI

CHD5

1056

Q8TDI0
EDLYPEHYRKYSDYI

DNMT1

966

P26358
YDIERPDLITYEPFY

ABLIM1

396

O14639
YEPFYTSGYDDKQER

ABLIM1

406

O14639
AARIYDYDPLYKEAL

APOBEC3A

126

P31941
YFDKILPYGDERHYS

ABCA6

416

Q8N139
YRGYQYLLEPGDFRH

CRYBB1

201

P53674
RYFEITDESPYVHYL

CORO1C

291

Q9ULV4
AYYRYIEKPPEDLDA

BRPF3

136

Q9ULD4
YISKDGLPYCEADYH

ABLIM2

191

Q6H8Q1
YASFRLEPESEYYKL

ANGPTL2

381

Q9UKU9
YGVVAQYYRPLHDEY

DENND3

76

A2RUS2
GDPDNYIAYYRRATV

DNAJC3

66

Q13217
PIYYRDSNGAILVYD

RAB21

86

Q9UL25
YRQYYVEAFGDPSER

NSD1

361

Q96L73
DGYGRVYTADPYHAL

RBFOX2

351

O43251
DIDFLPAYSLYDYLR

LARGE2

521

Q8N3Y3
PFEVLGTSGYDYYHI

NPAS2

276

Q99743
DLKLGPYVDHYYRDY

ANAPC1

796

Q9H1A4
YREKSLYGDDLDPYY

PAK5

146

Q9P286
LYGDDLDPYYRGSHA

PAK5

151

Q9P286
IDAYAEDHGPIYNYR

CACNA1F

1096

O60840
LYLHLYDVFGDPAYL

LANCL1

71

O43813
PRFVVYSYKYVHDDG

GMFG

66

O60234
YYAVNYPLRDGIDDE

HDAC1

221

Q13547
GYIDYYEFVAALHPN

DST

7251

Q03001
EPEELLGRSIYEYYH

HIF1A

266

Q16665
DLPDELLYGRAGYLY

LANCL2

191

Q9NS86
YDYPNSSEDYIHRIG

DDX5

416

P17844
SPEEAGRYLETYKAY

ERCC1

201

P07992
DYVDPDIFYAGIRIF

IDO2

236

Q6ZQW0
DLDRSGIPYLDYRTY

PLXNA2

1306

O75051
EDYTYFRIDPYLGDI

FAT2

2111

Q9NYQ8
YRYRYPKGESYEDLV

PFKFB4

356

Q16877
YHRDAGLPVYLYEFE

CES4A

436

Q5XG92
DGYIDYYEFVAALHP

MACF1

3221

O94854
HAIAIDYDPVEGYIY

LRP6

361

O75581
VEEALAHPYLEQYYD

MAPK3

321

P27361
YVPVANRYEGTEDDY

PGAP4

161

Q9BRR3
CEGPQRFEEYEYLGY

P3H2

251

Q8IVL5
YAAPELFRDEHYIGI

NIM1K

236

Q8IY84
YAALEDYHPAELYRA

TAMALIN

56

Q7Z6J2
ALSPDGYYARSEDYV

PLOD2

431

O00469
PRYEDYVDQHYKEFL

IFT172

1386

Q9UG01
AYYRDAEAYRHSPVF

GATA1

61

P15976
SPYEVHDYIRAYLGD

GIGYF2

1166

Q6Y7W6
YYVAVGEDEFKDLPY

DCDC2B

196

A2VCK2
ETDFGLRVAYDLVYY

FCGBP

3761

Q9Y6R7
YKEGSDRYYPPREEE

CRISPLD1

241

Q9H336
LEFSSYGYPREEIVY

GABRG2

206

P18507
YYRAPELIFGATDYT

GSK3B

221

P49841
AYKAGLIFRYPEEDY

DENND4C

206

Q5VZ89
QDLPGYYYRDDSLAV

ALOX12B

491

O75342
ISYGDDYADLPEYFK

FAM118B

301

Q9BPY3
DVHLNFYVYYGPDRI

HLTF

501

Q14527
RSLPYDDKLVYAEDY

ESRRB

291

O95718
YKELRLRGYDYGPHF

FASN

991

P49327
ELGDYDPYKHTAGYV

EPB41L4A

146

Q9HCS5
ARGFQVPYVTYDEDY

SCUBE2

911

Q9NQ36
ARGFQIPYVTYDEDY

SCUBE3

906

Q8IX30
PYYYFTRKPEEADRE

IFT140

726

Q96RY7
VKRLPLEYSYGEYRD

C8B

321

P07358
DGYVYKYDLSLPVER

D2HGDH

396

Q8N465
EQYLYGDDRIEPYIH

KIFAP3

696

Q92845
ADYYIIAGVIYQAPD

MED6

96

O75586
APEQYRFCYDVALEY

PTPRK

1421

Q15262
EGVCDKSPLERYYDY

MELTF

196

P08582
ESKEDIPYYFYRDDG

ALOX5

461

P09917
YHEGYELAQEFAPYK

ARHGAP42

211

A6NI28
PGEHAKDEYVLYYYS

JAML

61

Q86YT9
PYEISRAPDELHYTY

RPN1

386

P04843
YVYPDERTALYGKFI

SETD7

146

Q8WTS6
EILYTPYGDIYHDTY

TENM1

2336

Q9UKZ4
AYSAYNPEVGYHRDL

TBC1D26

176

Q86UD7
ATLKEYPAVRYRGEY

STXBP1

181

P61764
PECLSYYEDRYPKHE

SOX30

646

O94993
YYEDRYPKHEGIFST

SOX30

651

O94993
FYYILDITYGKEDVP

SETDB1

676

Q15047
SIGGIHEDYQLPYYD

TGFBR1

416

P36897
EYYDGKTRRYVDFPI

ASCC3

1666

Q8N3C0
VKFDAVSGDYYPIIY

CLPTM1

266

O96005
SEEGPADEYYIIYRN

CLHC1

41

Q8NHS4
NITDPEYGYLAREYI

CNGA2

311

Q16280
QRKRDGPDLAEYYYD

C11orf94

81

C9JXX5
DVIYHIQYDEYPESG

UHRF2

206

Q96PU4
YAPEEGNRYDGIYKV

UHRF2

576

Q96PU4
YKDGDLRIIPDSNYY

SPIN4

171

Q56A73
EYVIYRGEQAYPEYL

TNKS

1291

O95271
YEGGYYHGKLIFPRE

UBE2J2

56

Q8N2K1
RPIIHFGSDYEDRYY

PRNP

136

P04156
HVAPDGRIYYYNADD

PRPF40B

101

Q6NWY9
GYVFYLLRDGIYRAD

ROS1

421

P08922
LAEYVIYRGEQAYPE

TNKS2

1136

Q9H2K2
AGSAPRYLLYYRSEE

VPREB3

61

Q9UKI3
YGLGRDPEDYIYDLY

USP31

696

Q70CQ4
FYLDLYPREGKYGHA

THOP1

411

P52888
KYGYTEDPLEVRIYD

ZNF638

216

Q14966
NGERYEPDSIYYLCL

ZMYM3

1126

Q14202
NVADYYPEYKLLFEG

ATP6V0D1

266

P61421