Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 ADGRL1 OR8H1 OR2T2 GPRC6A OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	5.66e-10	884	68	18	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	1.97e-09	431	68	13	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 PKD1 GPR141 ADGRL1 GRIA2 OR8H1 OR2T2 GPRC6A OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	1.29e-08	1353	68	20	GO:0004888
GeneOntologyMolecularFunction	monoatomic cation channel activity	PIEZO2 KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1	2.11e-05	343	68	8	GO:0005261
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY10 ADCY3 ADCY8	2.97e-05	18	68	3	GO:0004016
GeneOntologyMolecularFunction	cyclase activity	ADCY10 ADCY3 ADCY8	7.26e-05	24	68	3	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY10 ADCY3 ADCY8	8.23e-05	25	68	3	GO:0016849
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY3 ADCY8	1.14e-04	5	68	2	GO:0008294
GeneOntologyMolecularFunction	monoatomic ion channel activity	PIEZO2 KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1	1.62e-04	459	68	8	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1 SLC34A3	1.77e-04	465	68	8	GO:0046873
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC24A2 SCN1A SCN3A GRIA2 SLC34A3	2.93e-04	171	68	5	GO:0015081
GeneOntologyMolecularFunction	channel activity	PIEZO2 KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1	4.01e-04	525	68	8	GO:0015267
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	PIEZO2 KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1 SLC34A3	4.02e-04	664	68	9	GO:0008324
GeneOntologyMolecularFunction	passive transmembrane transporter activity	PIEZO2 KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1	4.06e-04	526	68	8	GO:0022803
GeneOntologyMolecularFunction	prostaglandin receptor activity	PTGFR PTGIR	6.16e-04	11	68	2	GO:0004955
GeneOntologyMolecularFunction	prostanoid receptor activity	PTGFR PTGIR	7.38e-04	12	68	2	GO:0004954
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN3A GRIA2	7.41e-04	52	68	3	GO:0005272
GeneOntologyMolecularFunction	odorant binding	OR8H2 OR14K1 OR8H1 OR6K6	9.28e-04	127	68	4	GO:0005549
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN3A	1.01e-03	14	68	2	GO:0031402
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1 SLC34A3	1.27e-03	627	68	8	GO:0022890
GeneOntologyMolecularFunction	icosanoid receptor activity	PTGFR PTGIR	1.33e-03	16	68	2	GO:0004953
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	PIEZO2 KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1 SLC34A3	1.42e-03	793	68	9	GO:0015075
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN3A	3.52e-03	26	68	2	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN3A	3.52e-03	26	68	2	GO:0031420
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	KCNH8 SLC24A2 SCN1A SCN3A PKD1 GRIA2 TRPM1 SLC34A3	4.12e-03	758	68	8	GO:0015318
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2T8 OR8H2 ADCY10 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 ADGRL1 OR8H1 OR2T2 GPRC6A TRPM1 OR6C65 OR2T12 ZDHHC3 PTGFR PTGIR ADCY3 OR2AE1 ADCY8 OR6K6	4.34e-11	1395	68	23	GO:0007186
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 ADCY3 OR2AE1 OR6K6	2.93e-10	465	68	14	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2T8 OR8H2 OR14K1 OR2K2 PIEZO2 OR2T33 OR2T35 SCN1A OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	5.34e-10	582	68	15	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR2T8 OR8H2 OR14K1 OR2K2 PIEZO2 OR2T33 OR2T35 SCN1A OR6C74 PKD1 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	1.16e-09	722	68	16	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	1.38e-09	432	68	13	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 ADCY3 OR2AE1 OR6K6	2.39e-09	547	68	14	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	5.53e-09	485	68	13	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	1.39e-08	524	68	13	GO:0009593
GeneOntologyBiologicalProcess	sensory perception	OR2T8 OR8H2 OR14K1 OR2K2 PIEZO2 OR2T33 OR2T35 SCN1A OR6C74 OR8H1 OR2T2 TRPM1 OR6C65 OR2T12 ADCY3 OR2AE1 OR6K6	4.73e-08	1072	68	17	GO:0007600
GeneOntologyBiologicalProcess	cAMP biosynthetic process	ADCY10 ADCY3 ADCY8	5.55e-06	11	68	3	GO:0006171
GeneOntologyBiologicalProcess	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ADCY10 ADGRL1 PTGFR PTGIR ADCY3 ADCY8	3.96e-05	191	68	6	GO:0007189
GeneOntologyBiologicalProcess	cyclic nucleotide biosynthetic process	ADCY10 ADCY3 ADCY8	5.79e-05	23	68	3	GO:0009190
GeneOntologyBiologicalProcess	cAMP metabolic process	ADCY10 ADCY3 ADCY8	7.48e-05	25	68	3	GO:0046058
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ADCY10 ADGRL1 PTGFR PTGIR ADCY3 ADCY8	3.59e-04	286	68	6	GO:0007188
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	ADCY10 ADCY3 ADCY8	4.12e-04	44	68	3	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	ADCY10 ADCY3 ADCY8	4.40e-04	45	68	3	GO:0009187
GeneOntologyBiologicalProcess	protein tetramerization	MS4A1 PKD1 GRIA2 TRPM1	5.31e-04	113	68	4	GO:0051262
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	MS4A1 SLC24A2 TRPM1	5.33e-04	48	68	3	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	MS4A1 SLC24A2 TRPM1	5.33e-04	48	68	3	GO:1902656
MousePheno	abnormal chemical nociception	ESR2 GRIA2 PTGIR ADCY8	1.38e-05	44	47	4	MP:0002735
Domain	Olfact_rcpt	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 OR2AE1 OR6K6	1.18e-09	393	67	13	IPR000725
Domain	7tm_1	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 OR8H1 OR2T2 OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	1.50e-09	677	67	16	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 OR8H1 OR2T2 OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	1.77e-09	685	67	16	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 OR8H1 OR2T2 OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	2.01e-09	691	67	16	PS50262
Domain	GPCR_Rhodpsn	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 OR8H1 OR2T2 OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	2.05e-09	692	67	16	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR2T8 OR8H2 OR2K2 OR2T33 OR2T35 OR6C74 GPR141 OR8H1 OR2T2 OR6C65 OR2T12 PTGFR PTGIR OR2AE1 OR6K6	1.10e-08	670	67	15	IPR017452
Domain	Nucleotide_cyclase	ADCY10 ADCY3 ADCY8	3.46e-05	18	67	3	IPR029787
Domain	-	ADCY10 ADCY3 ADCY8	3.46e-05	18	67	3	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY10 ADCY3 ADCY8	4.10e-05	19	67	3	PS00452
Domain	Guanylate_cyc	ADCY10 ADCY3 ADCY8	4.10e-05	19	67	3	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY10 ADCY3 ADCY8	4.10e-05	19	67	3	PS50125
Domain	A/G_cyclase	ADCY10 ADCY3 ADCY8	4.10e-05	19	67	3	IPR001054
Domain	CYCc	ADCY10 ADCY3 ADCY8	4.10e-05	19	67	3	SM00044
Domain	-	GTF2IRD2B GTF2IRD2	7.57e-05	4	67	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	7.57e-05	4	67	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	7.57e-05	4	67	2	PF02946
Domain	GTF2I	GTF2IRD2B GTF2IRD2	7.57e-05	4	67	2	IPR004212
Domain	Thbox_rcpt	PTGFR PTGIR	1.26e-04	5	67	2	IPR001105
Domain	Na_trans_cytopl	SCN1A SCN3A	1.88e-04	6	67	2	PF11933
Domain	Na_trans_cytopl	SCN1A SCN3A	1.88e-04	6	67	2	IPR024583
Domain	ARM-type_fold	NCAPD3 DOCK11 NOM1 INTS1 TMCO6 UNC79 SDAD1	2.08e-04	339	67	7	IPR016024
Domain	Prostanoid_rcpt	PTGFR PTGIR	3.50e-04	8	67	2	IPR008365
Domain	AC_N	ADCY3 ADCY8	3.50e-04	8	67	2	IPR032628
Domain	Adcy	ADCY3 ADCY8	3.50e-04	8	67	2	IPR030672
Domain	AC_N	ADCY3 ADCY8	3.50e-04	8	67	2	PF16214
Domain	Na_channel_asu	SCN1A SCN3A	5.60e-04	10	67	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN3A	5.60e-04	10	67	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN3A	5.60e-04	10	67	2	PF06512
Domain	Ion_trans_dom	KCNH8 SCN1A SCN3A TRPM1	7.50e-04	114	67	4	IPR005821
Domain	Ion_trans	KCNH8 SCN1A SCN3A TRPM1	7.50e-04	114	67	4	PF00520
Domain	A/G_cyclase_CS	ADCY3 ADCY8	1.67e-03	17	67	2	IPR018297
Domain	GPS	PKD1 ADGRL1	6.60e-03	34	67	2	SM00303
Domain	GPS	PKD1 ADGRL1	6.99e-03	35	67	2	PF01825
Domain	GPS	PKD1 ADGRL1	7.38e-03	36	67	2	PS50221
Domain	GPS	PKD1 ADGRL1	7.79e-03	37	67	2	IPR000203
Domain	ANF_lig-bd_rcpt	GRIA2 GPRC6A	7.79e-03	37	67	2	IPR001828
Domain	ANF_receptor	GRIA2 GPRC6A	7.79e-03	37	67	2	PF01094
Domain	Peripla_BP_I	GRIA2 GPRC6A	8.62e-03	39	67	2	IPR028082
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 ADCY3 OR2AE1 OR6K6	2.66e-10	417	53	14	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T8 OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 SCN3A OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 ADCY3 OR2AE1 OR6K6	7.02e-09	636	53	15	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T8 OR8H2 OR2K2 OR2T33 OR6C74 OR8H1 OR2T2 OR6C65 OR2T12 ADCY3 OR2AE1 OR6K6	1.58e-08	389	53	12	M14091
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY10 ADCY3 ADCY8	2.71e-05	16	53	3	M39849
Pathway	REACTOME_PROSTANOID_LIGAND_RECEPTORS	PTGFR PTGIR	4.91e-04	9	53	2	MM15014
Pathway	REACTOME_PROSTANOID_LIGAND_RECEPTORS	PTGFR PTGIR	4.91e-04	9	53	2	M804
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY3 ADCY8	6.12e-04	10	53	2	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY3 ADCY8	6.12e-04	10	53	2	MM14668
Pathway	WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY	ADCY10 ADCY3 ADCY8	6.80e-04	46	53	3	M39828
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	ADCY10 ADCY3 ADCY8	1.15e-03	55	53	3	M39763
Pathway	REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS	PTGFR PTGIR	1.23e-03	14	53	2	MM15012
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY3 ADCY8	1.23e-03	14	53	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY3 ADCY8	1.23e-03	14	53	2	M750
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY3 ADCY8	1.41e-03	15	53	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY3 ADCY8	1.41e-03	15	53	2	M56
Pathway	REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS	PTGFR PTGIR	1.41e-03	15	53	2	M10620
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY3 ADCY8	1.41e-03	15	53	2	M47504
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY3 ADCY8	1.61e-03	16	53	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY3 ADCY8	1.61e-03	16	53	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY3 ADCY8	1.61e-03	16	53	2	MM14492
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY3 ADCY8	1.82e-03	17	53	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY3 ADCY8	1.82e-03	17	53	2	M47544
Pathway	WP_GPCRS_SMALL_LIGAND	PTGFR PTGIR	2.04e-03	18	53	2	MM15858
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	TRPM1 DICER1	2.28e-03	19	53	2	M48238
Pathway	WP_SMALL_LIGAND_GPCRS	PTGFR PTGIR	2.28e-03	19	53	2	M39728
Pathway	BIOCARTA_EICOSANOID_PATHWAY	PTGFR PTGIR	2.52e-03	20	53	2	MM1529
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY3 ADCY8	2.52e-03	20	53	2	M759
Pathway	BIOCARTA_EICOSANOID_PATHWAY	PTGFR PTGIR	3.05e-03	22	53	2	M22003
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T8 OR8H2 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR6C65 OR2T12 OR6K6	1.55e-09	343	69	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T8 OR8H2 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR6C65 OR2T12 OR6K6	1.69e-09	346	69	10	14611657
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T8 OR8H2 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR6C65 OR2T12	2.48e-08	340	69	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T8 OR8H2 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR6C65 OR2T12	2.48e-08	340	69	9	11802173
Pubmed	The human olfactory receptor gene family.	OR8H2 OR14K1 OR2K2 OR2T33 OR2T35 OR6C74 OR8H1 OR2T2 OR2T12 OR6K6	1.14e-07	541	69	10	14983052
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	MS4A1 ADCY3 ADCY8	1.22e-06	11	69	3	10808179
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR2T8 OR2T35 OR2T2 OR2T12	2.17e-06	46	69	4	32126975
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY10 ADCY3 ADCY8	2.68e-06	14	69	3	14993377
Pubmed	Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists.	ADCY10 ADCY3	3.88e-06	2	69	2	16291925
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	3.88e-06	2	69	2	24990319
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	3.88e-06	2	69	2	27690330
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	3.88e-06	2	69	2	15388857
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	3.88e-06	2	69	2	23965409
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN3A	1.16e-05	3	69	2	12610651
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A	1.16e-05	3	69	2	33895391
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN3A	1.16e-05	3	69	2	23859570
Pubmed	Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia.	ADCY3 ADCY8	1.16e-05	3	69	2	17586501
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN3A	1.16e-05	3	69	2	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN3A	1.16e-05	3	69	2	17544618
Pubmed	A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.	ADCY3 ADCY8	1.16e-05	3	69	2	8476432
Pubmed	GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.	SCN1A SCN3A	1.16e-05	3	69	2	27816501
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	1.16e-05	3	69	2	15100712
Pubmed	Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth.	ADCY10 ADCY8	1.16e-05	3	69	2	22649251
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN3A	1.16e-05	3	69	2	14973256
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN3A	2.32e-05	4	69	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN3A	2.32e-05	4	69	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN3A	2.32e-05	4	69	2	29578003
Pubmed	Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.	PTGFR PTGIR	2.32e-05	4	69	2	18938093
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2B GTF2IRD2	2.32e-05	4	69	2	17823943
Pubmed	Evolution of general transcription factors.	GTF2IRD2B GTF2IRD2	2.32e-05	4	69	2	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2B GTF2IRD2	2.32e-05	4	69	2	22899722
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2B GTF2IRD2	2.32e-05	4	69	2	21328569
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN3A	2.32e-05	4	69	2	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN3A	2.32e-05	4	69	2	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN3A	3.86e-05	5	69	2	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN3A	3.86e-05	5	69	2	8812438
Pubmed	Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.	GRIA2 ZDHHC3	3.86e-05	5	69	2	16129400
Pubmed	A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.	INTS1 UNC79	3.86e-05	5	69	2	16807365
Pubmed	MicroRNAs regulate renal tubule maturation through modulation of Pkd1.	PKD1 DICER1	3.86e-05	5	69	2	23138483
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN3A	3.86e-05	5	69	2	24337656
Pubmed	Mechanoreceptor synapses in the brainstem shape the central representation of touch.	PIEZO2 PTGFR	5.79e-05	6	69	2	34637701
Pubmed	Chromosomal localization of the human prostanoid receptor gene family.	PTGFR PTGIR	5.79e-05	6	69	2	7759114
Pubmed	Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.	UBR1 ADCY3	5.79e-05	6	69	2	17462990
Pubmed	Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease.	PKD1 ADCY3	5.79e-05	6	69	2	30799240
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN3A	5.79e-05	6	69	2	23652591
Pubmed	Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor.	PTGFR PTGIR	5.79e-05	6	69	2	15983244
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY3 ADCY8	8.09e-05	7	69	2	12613887
Pubmed	Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.	PTGFR PTGIR	1.08e-04	8	69	2	15834430
Pubmed	The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.	PTGFR PTGIR	1.08e-04	8	69	2	11927615
Pubmed	Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma.	PTGFR PTGIR	1.08e-04	8	69	2	17496729
Pubmed	Prostanoid receptors: structures, properties, and functions.	PTGFR PTGIR	1.08e-04	8	69	2	10508233
Pubmed	Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis.	PTGFR PTGIR	1.08e-04	8	69	2	20566843
Pubmed	Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta.	PTGFR PTGIR	1.08e-04	8	69	2	19966781
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY3 ADCY8	1.38e-04	9	69	2	9417641
Pubmed	Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression.	PTGFR PTGIR	1.38e-04	9	69	2	21460251
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY3 ADCY8	1.38e-04	9	69	2	12503609
Pubmed	Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.	PTGFR PTGIR	1.38e-04	9	69	2	11782353
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN3A	1.38e-04	9	69	2	16382098
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY3 ADCY8	1.38e-04	9	69	2	17229090
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN3A	1.38e-04	9	69	2	15746173
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY3 ADCY8	1.73e-04	10	69	2	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY3 ADCY8	1.73e-04	10	69	2	16615126
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY3 ADCY8	1.73e-04	10	69	2	11884542
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY3 ADCY8	2.11e-04	11	69	2	11299302
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY3 ADCY8	2.11e-04	11	69	2	10089566
Pubmed	Genome-wide association study of body mass index in 23 000 individuals with and without asthma.	SLC24A2 ADCY3	2.11e-04	11	69	2	23517042
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN3A	2.53e-04	12	69	2	8169823
Pubmed	Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex.	MS4A1 DICER1	2.53e-04	12	69	2	23518926
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN3A	2.53e-04	12	69	2	30175250
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY3 ADCY8	2.53e-04	12	69	2	10807185
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN3A	2.98e-04	13	69	2	15123669
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BPTF NOM1 INTS1 BIRC6 UNC79 BAG6	3.41e-04	469	69	6	27634302
Pubmed	Enhancer interaction networks as a means for singular olfactory receptor expression.	BPTF ADCY3	3.48e-04	14	69	2	25417106
Pubmed	Mechanism of GTP hydrolysis by G-protein alpha subunits.	ADCY3 ADCY8	4.01e-04	15	69	2	7937899
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY3 ADCY8	4.01e-04	15	69	2	2165385
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN3A	4.01e-04	15	69	2	9726281
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY3 ADCY8	4.57e-04	16	69	2	17567809
Pubmed	Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons.	ADCY3 OR6K6	4.57e-04	16	69	2	25437545
Pubmed	Olfactory receptors and signalling elements in the Grueneberg ganglion.	OR8H2 OR8H1	5.18e-04	17	69	2	16805845
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OR2K2 DOCK11 SCN3A INTS1 PKD1 SLFN5 BIRC6	6.39e-04	736	69	7	29676528
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	GTF2IRD2B GTF2IRD2	6.49e-04	19	69	2	30228200
Pubmed	Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line.	UBR1 RASGRP1	7.20e-04	20	69	2	17082620
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ADCY10 TRPM1 SDAD1 DOP1A	7.93e-04	208	69	4	33230847
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	UBR1 NCAPD3 DICER1 BAG6	8.51e-04	212	69	4	33853758
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C74 OR6C65	1.04e-03	24	69	2	24152035
Pubmed	Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors.	PTGFR PTGIR	1.04e-03	24	69	2	8833158
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	PKD1 ADCY3	1.13e-03	25	69	2	28154160
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NCAPD3 INTS1 PAQR5 ZDHHC3 DICER1 BAG6 KYNU SEPTIN2	1.18e-03	1061	69	8	33845483
Pubmed	Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.	PTGFR PTGIR	1.32e-03	27	69	2	23624557
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR8H2 OR8H1	1.32e-03	27	69	2	32061665
Pubmed	Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.	RASGRP1 SLC24A2	1.52e-03	29	69	2	28344592
Pubmed	Glucagon and regulation of glucose metabolism.	ADCY3 ADCY8	1.74e-03	31	69	2	12626323
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 NCAPD3 NOM1 FHIP2A DICER1 KYNU	1.84e-03	650	69	6	38777146
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	LRSAM1 BAG6	1.85e-03	32	69	2	19542561
Pubmed	Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.	PTGFR PTGIR	1.97e-03	33	69	2	39002541
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	PKD1 TRPM1	1.97e-03	33	69	2	19834762
Interaction	OR2T12 interactions	OR2T33 OR2T12	9.01e-06	2	61	2	int:OR2T12
Cytoband	1q44	OR2T8 OR14K1 OR2T33 OR2T35 OR2T2 OR2T12	1.75e-08	110	69	6	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T8 OR14K1 OR2T33 OR2T35 OR2T2 OR2T12	4.33e-08	128	69	6	chr1q44
GeneFamily	Olfactory receptors, family 2	OR2T8 OR2K2 OR2T33 OR2T35 OR2T2 OR2T12 OR2AE1	3.28e-08	113	52	7	149
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY10 ADCY3 ADCY8	2.65e-06	10	52	3	53
GeneFamily	Prostaglandin (prostanoid) receptors	PTGFR PTGIR	2.88e-04	9	52	2	207
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN3A	2.88e-04	9	52	2	1203
GeneFamily	Olfactory receptors, family 6	OR6C74 OR6C65 OR6K6	4.24e-04	51	52	3	153
Coexpression	GSE23502_BM_VS_COLON_TUMOR_HDC_KO_MYELOID_DERIVED_SUPPRESSOR_CELL_UP	UBR1 SLC24A2 SCN1A PAQR5 GRIA2 UNC79	1.43e-05	199	69	6	M8082
CoexpressionAtlas	DevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_1000	COL24A1 PIEZO2 DOCK11 SCN1A SCN3A PTGFR PTGIR	2.99e-06	234	57	7	gudmap_developingKidney_e15.5_Peripheral blastema_1000_k2
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MS4A1 LINC00862 SCN3A DNAH8 DOP1A	1.30e-05	195	69	5	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN3A PKD1 GRIA2 UNC79	1.40e-05	198	69	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 SCN3A GRIA2 SLC34A3 UNC79	1.40e-05	198	69	5	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 SCN3A GRIA2 SLC34A3 UNC79	1.40e-05	198	69	5	e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SGCZ GRIA2 DNAH8 ADCY8	8.67e-05	150	69	4	0205318a870e091add66ee4305747dda9f51510d
ToppCell	Healthy_donor-B_cell\|Healthy_donor / disease group, cell group and cell class (v2)	COL24A1 MS4A1 SCN3A DNAH8	9.13e-05	152	69	4	5768edfde8010324d8594815e73bbfba2c3045f3
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Platelets-Platelets\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCN3A TRPM1 SLC51A DNAH8	9.13e-05	152	69	4	aff7d1127ef72be489477611c4decc53cc7632e3
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Platelets\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCN3A TRPM1 SLC51A DNAH8	9.13e-05	152	69	4	0a99c91165e4d82fb8825fbdf3071c9a5445669d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN1A GRIA2 ADCY3	9.60e-05	154	69	4	3211f003f4d1735c7cab9b6cc68af3e0bbfba35e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN1A GRIA2 ADCY3	9.60e-05	154	69	4	c0fe767fc9ab45b2dfa71171f2a673a4a8decbaf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN1A GRIA2 ADCY3	9.60e-05	154	69	4	4c2a7590791c2255b15dab82c3622f71f9ffd949
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tregs\|GI_small-bowel / Manually curated celltypes from each tissue	ADCY10 RNF175 DNAH8 PTGIR	1.03e-04	157	69	4	c44bd530e396b08f16f284e185dcb830843959ea
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNH8 SCN3A GRIA2 UNC79	1.09e-04	159	69	4	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	COVID-CD8-memory_CD4\|COVID / Condition, Cell_class and T cell subcluster	MS4A1 ESR2 PKD1 DOP1A	1.17e-04	162	69	4	22b2a32217d357146c117e618813d451510a1801
ToppCell	Immune_cells-B_cell\|World / Lineage and Cell class	RASGRP1 MS4A1 KYNU PDCD1LG2	1.19e-04	163	69	4	3a02465de7c2f7cea227e289fb082a1fb6400301
ToppCell	facs-Heart-LA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MS4A1 TRPM1 KYNU PDCD1LG2	1.31e-04	167	69	4	8ce8d93c79ac6a3f52252b4cec53378c362bfe0a
ToppCell	facs-Heart-LA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MS4A1 TRPM1 KYNU PDCD1LG2	1.31e-04	167	69	4	8340f7075d00dccb304cfd4c9b5711ca6dbf7cce
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGRP1 DOCK11 NOM1 BIRC6	1.31e-04	167	69	4	063ec29b32e40aaa138a691da3a79ee8eef0c2be
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	KCNH8 MS4A1 SCN3A KYNU	1.34e-04	168	69	4	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	KCNH8 MS4A1 SCN3A KYNU	1.34e-04	168	69	4	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell	-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	COL24A1 RASGRP1 PIEZO2 MS4A1	1.40e-04	170	69	4	601630644f09133ee4c5e64499460b55cf3e80a0
ToppCell	Bronchial_Brush-Immune-B_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	COL24A1 RASGRP1 MS4A1 ASAH2	1.40e-04	170	69	4	53e9372cb06a2dc5c8ecb3f9af42f3c23da96431
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASAH2 SCN3A PAQR5 GRIA2	1.44e-04	171	69	4	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASAH2 SCN3A PAQR5 GRIA2	1.44e-04	171	69	4	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASAH2 SCN3A PAQR5 GRIA2	1.44e-04	171	69	4	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASAH2 SCN3A PAQR5 GRIA2	1.44e-04	171	69	4	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP1 MS4A1 DOCK11 KYNU	1.44e-04	171	69	4	a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP1 MS4A1 DOCK11 KYNU	1.44e-04	171	69	4	43d8fd9b9546e84a652564fe96b514b34b06262b
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD PAQR5 UNC79 KYNU	1.50e-04	173	69	4	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD PAQR5 UNC79 KYNU	1.50e-04	173	69	4	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	PIEZO2 KCNH8 GRIA2 UNC79	1.57e-04	175	69	4	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	PIEZO2 KCNH8 GRIA2 UNC79	1.57e-04	175	69	4	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 SGCZ MS4A1 ADCY8	1.57e-04	175	69	4	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	KCNH8 MS4A1 SCN3A DNAH8	1.64e-04	177	69	4	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	NS-moderate-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL24A1 DOCK11 LINC00862 ESR2	1.64e-04	177	69	4	de1ffe3df76100d46ca158bdd2fea2ebbd4656b4
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	KCNH8 MS4A1 SCN3A DNAH8	1.64e-04	177	69	4	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 SCN1A SCN3A GRIA2	1.64e-04	177	69	4	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 SCN1A SCN3A GRIA2	1.64e-04	177	69	4	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	BAL-Severe-Lymphocyte-B-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MS4A1 SCN3A SLC34A3 DNAH8	1.68e-04	178	69	4	499640cfb1063aa40343ec1563e40fe4645466fb
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MS4A1 SCN3A SLC34A3 DNAH8	1.68e-04	178	69	4	851fdcf1451880a048885cc6677b4edfff6aee4c
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	MS4A1 SCN3A SLC34A3 DNAH8	1.68e-04	178	69	4	1a3b3b73e81ceb26cec8153cd1bdd7b446887a71
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNH8 MS4A1 UNC79 KYNU	1.71e-04	179	69	4	fce1ba53815145f6248d4e90aedca3dad84e33e4
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	KCNH8 MS4A1 SCN3A DNAH8	1.79e-04	181	69	4	700adfb41e4e377530f0dd31be89e12f109f3469
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	KCNH8 SCN3A GRIA2 UNC79	1.82e-04	182	69	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PIEZO2 KCNH8 GPR141 TRPM1	1.82e-04	182	69	4	d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SGCZ PIEZO2 DOCK11 ADCY8	1.82e-04	182	69	4	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	B_cells-ABCs\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	DOCK11 SLFN5 DNAH8 PDCD1LG2	1.86e-04	183	69	4	bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCell	Mild-Lymphoid-B\|Mild / Condition, Lineage, Cell class and cell subclass	KCNH8 MS4A1 SCN3A DNAH8	1.86e-04	183	69	4	9b64d2d143525e6f48a191facfd101462ff36324
ToppCell	Mild-Lymphoid-B-\|Mild / Condition, Lineage, Cell class and cell subclass	KCNH8 MS4A1 SCN3A DNAH8	1.86e-04	183	69	4	b5740f05a4dcdbbf24f7bf7a3f57ac01a5e75f60
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 PIEZO2 SLC24A2 UNC79	1.90e-04	184	69	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-CD5+_CCL22+_mature_B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	DUSP29 MS4A1 ESR2 KYNU	1.90e-04	184	69	4	5bb775253a10a14360b06a46aba46d162a9bd1f8
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 PIEZO2 SLC24A2 UNC79	1.90e-04	184	69	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	CTRL-Lymphoid\|CTRL / Disease state, Lineage and Cell class	RASGRP1 MS4A1 SCN3A DNAH8	1.90e-04	184	69	4	26fb2c4e6cb9950c27eb15428e7e74e5abb4397d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL24A1 PIEZO2 SLC24A2 UNC79	1.90e-04	184	69	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KCNH8 MS4A1 SCN3A DNAH8	1.90e-04	184	69	4	3f8a359e40bebe58545f708682e5e5d1b70cf5cb
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KCNH8 MS4A1 SCN3A DNAH8	1.90e-04	184	69	4	64bede8db709fd32f40c03265b96f0b12155bb8a
ToppCell	(7)_DC_activated\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	ADCY10 PIEZO2 PTGIR PDCD1LG2	1.90e-04	184	69	4	b89871a3e36fde6daa68daf116f8c8d587554c0f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN3A PTGIR ADCY3	1.94e-04	185	69	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	KCNH8 MS4A1 SCN3A DNAH8	1.94e-04	185	69	4	609080adb2cfb105bb7b8efb617553833299f371
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN3A PTGIR ADCY3	1.94e-04	185	69	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	3'_v3-blood-Lymphocytic_B\|blood / Manually curated celltypes from each tissue	KCNH8 MS4A1 SCN3A DNAH8	1.98e-04	186	69	4	5624b1fc7eab9f505588fcc86a24d14f8bcbfef7
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 SCN3A GRIA2 TENT5D	1.98e-04	186	69	4	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNH8 SCN3A GRIA2 UNC79	1.98e-04	186	69	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIEZO2 GPR141 PTGIR KYNU	2.02e-04	187	69	4	d69f4eee0304a7db226275ab77fc9d5d2b6f3a07
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNH8 SCN3A GRIA2 UNC79	2.06e-04	188	69	4	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGCZ MS4A1 SLC24A2 ADGRL1	2.06e-04	188	69	4	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	MS-Treg-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	RASGRP1 SLFN5 DNAH8 PTGIR	2.11e-04	189	69	4	b1310eed6113b3536868340a5b2b2587ad377fa9
ToppCell	MS-Treg\|MS / Condition, Cell_class and T cell subcluster	RASGRP1 SLFN5 DNAH8 PTGIR	2.11e-04	189	69	4	3fa79242fb3dba4a3f52276da0124ba260423fb6
ToppCell	CF-Lymphoid-B_cell\|CF / Disease state, Lineage and Cell class	RASGRP1 MS4A1 SCN3A DNAH8	2.15e-04	190	69	4	374d8fd63c733178acab07682ed1519693efab45
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 SCN3A GRIA2 TENT5D	2.15e-04	190	69	4	db19c72d8c8053262b535068c5a9d4d696989cb1
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGCZ MS4A1 SLC24A2 ADGRL1	2.19e-04	191	69	4	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SGCZ PIEZO2 DOCK11 ADCY8	2.19e-04	191	69	4	782bc7946417549ffd39e5b596db659436fa01ba
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCN1A SCN3A GRIA2 SEPTIN2	2.24e-04	192	69	4	1d0d6fb89a2b941b7caab2f1f07d6bd5433a11e7
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MS4A1 LINC00862 SCN3A DNAH8	2.33e-04	194	69	4	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH8 MS4A1 DNAH8 KYNU	2.37e-04	195	69	4	3311a1bf4ed94820b45047d44fc14b14ac72e6fb
ToppCell	severe-Lymphocytic-B_cells_1\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KCNH8 MS4A1 SCN3A KYNU	2.37e-04	195	69	4	73e39005a597e13aea571ae6ae5824d1c7448b71
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN3A PKD1 GRIA2 UNC79	2.42e-04	196	69	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN3A PTGIR ADCY3	2.47e-04	197	69	4	bc6c530330907a5ec823cc243c8e9c9e340cfb9c
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 SCN3A PTGIR ADCY3	2.47e-04	197	69	4	77fe092aae8f05fe137680506892d2f61071d6ea
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN3A GRIA2 UNC79	2.52e-04	198	69	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LINC00862 OR2T12 RNF175 PTGFR	2.52e-04	198	69	4	5d57acbe0d245f8bd217eeea07af060092898fbd
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN3A GRIA2 UNC79	2.52e-04	198	69	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPR141 PTGIR KYNU PDCD1LG2	2.56e-04	199	69	4	f4ab29f99ce45a3044d2e9f356dc24d3c5e7121f
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PIEZO2 DOCK11 PAQR5 ADCY8	2.61e-04	200	69	4	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PIEZO2 DOCK11 PAQR5 ADCY8	2.61e-04	200	69	4	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SGCZ PIEZO2 DOCK11 ADCY8	2.61e-04	200	69	4	5ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SGCZ PIEZO2 DOCK11 ADCY8	2.61e-04	200	69	4	e79d93d55b25804f2608185168da472301b6ebca
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PIEZO2 DOCK11 PAQR5 ADCY8	2.61e-04	200	69	4	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SGCZ PIEZO2 DOCK11 ADCY8	2.61e-04	200	69	4	320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
Computational	Genes upregulated in subsets of cells of a given type within various tumors	BPTF RASGRP1 SLFN5	2.99e-04	49	29	3	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Drug	sulprostone	ADCY10 PTGFR PTGIR ADCY3 ADCY8	2.12e-06	71	67	5	CID005312153
Drug	AC1NY9KD	PTGIR ADCY3 ADCY8	3.95e-06	11	67	3	CID005771741
Drug	AC1NIP3C	PTGFR PTGIR ADCY3 ADCY8	6.39e-06	41	67	4	CID004834553
Drug	Dinoprost Tromethamine	PTGFR PTGIR	8.53e-06	2	67	2	DB01160
Drug	BMY 42393	PTGIR ADCY3 ADCY8	1.08e-05	15	67	3	CID000131961
Drug	AC1L1EKQ	GRIA2 PTGIR ADCY3 ADCY8	1.67e-05	52	67	4	CID000002834
Drug	8-iso Misoprostol	PTGFR PTGIR ADCY3 ADCY8	3.36e-05	62	67	4	CID004183806
Drug	iloprost	ADCY10 PTGFR PTGIR ADCY3 ADCY8	4.72e-05	134	67	5	CID005311181
Drug	4-NA	SLC24A2 ESR2	5.10e-05	4	67	2	CID006102690
Drug	octimibate	PTGIR ADCY3 ADCY8	5.35e-05	25	67	3	CID000065676
Drug	i-Pr	ADGRL1 PTGIR ADCY3 ADCY8	6.40e-05	73	67	4	CID000448400
Drug	SM-10906	PTGIR ADCY3 ADCY8	6.77e-05	27	67	3	CID006442261
Drug	Prostaglandin D2-d4	RASGRP1 MS4A1 PTGFR PTGIR ADCY3 ADCY8	7.52e-05	240	67	6	CID000004956
Drug	prenalterol	ADCY10 ADCY3 ADCY8	7.57e-05	28	67	3	CID000042396
Drug	Beraprost-d3	ADCY10 PTGIR ADCY3 ADCY8	7.88e-05	77	67	4	CID000002352
Drug	butaprost	PTGFR PTGIR ADCY3 ADCY8	8.29e-05	78	67	4	CID005311035
Drug	mitoxantrone	IFNW1 MS4A1 ADCY3 ADCY8 SEPTIN2	9.14e-05	154	67	5	CID000004212
Drug	AC1N2DGT	PTGIR ADCY3 ADCY8	9.34e-05	30	67	3	CID004045015
Drug	AC1L1DXN	PTGFR PTGIR ADCY3 ADCY8	1.21e-04	86	67	4	CID000002552
Drug	AC1L1FGW	SLC51A PTGFR PTGIR	1.25e-04	33	67	3	CID000003231
Disease	height-adjusted body mass index	ADCY3 ADCY8	1.39e-05	3	64	2	EFO_0005851
Disease	anxiety disorder (implicated_via_orthology)	SCN1A ESR2 SCN3A	1.46e-05	22	64	3	DOID:2030 (implicated_via_orthology)
Disease	depressive symptom measurement, response to antidepressant	SGCZ ZDHHC3 ADCY3 ADCY8	4.09e-05	88	64	4	EFO_0007006, GO_0036276
Disease	COVID-19, obesity	ADCY3 ADCY8	9.66e-05	7	64	2	EFO_0001073, MONDO_0100096
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN3A	2.06e-04	10	64	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN3A	2.06e-04	10	64	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN3A	3.01e-04	12	64	2	DOID:0060170 (implicated_via_orthology)
Disease	waist circumference	BPTF SLC24A2 ESR2 HECTD4 ADCY3 ADCY8	3.36e-04	429	64	6	EFO_0004342
Disease	Connective Tissue Diseases	PIEZO2 PKD1	3.56e-04	13	64	2	C0009782
Disease	magnesium measurement	SGCZ NOM1 ADCY8	4.04e-04	66	64	3	EFO_0004845
Disease	Endometrioma	RASGRP1 ESR2 PTGFR DICER1	4.20e-04	161	64	4	C0269102
Disease	Endometriosis	RASGRP1 ESR2 PTGFR DICER1	4.20e-04	161	64	4	C0014175
Disease	Diabetic Angiopathies	ADCY3 ADCY8	5.45e-04	16	64	2	C0011875
Disease	Microangiopathy, Diabetic	ADCY3 ADCY8	5.45e-04	16	64	2	C0025945
Disease	visceral adipose tissue measurement	BPTF SGCZ PKD1 UNC79 ADCY3 ADCY8	6.13e-04	481	64	6	EFO_0004765
Disease	grip strength measurement	BPTF PKD1 UNC79 ADCY3 ADCY8	9.81e-04	350	64	5	EFO_0006941
Disease	unipolar depression	BPTF RASGRP1 SGCZ PIEZO2 KCNH8 MS4A1 ESR2 PKD1 OR2T12	1.13e-03	1206	64	9	EFO_0003761
Disease	sex interaction measurement, body mass index, age at assessment	ADCY3 ADCY8	1.14e-03	23	64	2	EFO_0004340, EFO_0008007, EFO_0008343
Disease	susceptibility to pneumonia measurement	DUSP29 ADCY3 ADCY8	1.24e-03	97	64	3	EFO_0008410
Disease	osteoarthritis (is_implicated_in)	ESR2 BAG6	1.69e-03	28	64	2	DOID:8398 (is_implicated_in)
Disease	mammographic density percentage	ADCY3 ADCY8	1.81e-03	29	64	2	EFO_0006502
Disease	Cocaine-Related Disorders	ESR2 GRIA2 DNAH8	2.12e-03	117	64	3	C0236736

Protein segments in the cluster

Peptide	Gene	Start	Entry
MTIQFSILIMLHSAL	ADCY8	741	P40145
LVLHSLTLMTNMQLN	BIRC6	2721	Q9NR09
LVMAQHMIRDIQTLL	BAG6	166	P46379
VVNLVFLMVTLHKMI	ADGRL1	1016	O94910
LQVMLTMHRIVISSA	RASGRP1	86	O95267
ILSILHMIMSSVTLL	DOP1A	1761	Q5JWR5
LIQLDSMRLSHQMLV	ADCY10	816	Q96PN6
FMLSLQMLELITRLH	DICER1	836	Q9UPY3
MILSIMDILNIKISH	MS4A1	131	P11836
TLMAEMHVVLLKAVL	BPTF	281	Q12830
MIFLLLMLSLELQLH	PDCD1LG2	1	Q9BQ51
LTHLIVQLDSDMIMS	SLC34A3	246	Q8N130
VFIIMLMVQKLRHSL	GPR141	201	Q7Z602
VILATHMQMEAILLD	PAQR5	261	Q9NXK6
MIIIMLTLSNIHLKT	OR6C65	41	A6NJZ3
MILIIRLDLQLHTPM	OR8H2	46	Q8N162
TANLVMILLIHMDSR	OR2T2	41	Q6IF00
AHQVLFMMLLATVLT	OR2T12	21	Q8NG77
QSMRLANLLMLLSHV	ESR2	451	Q92731
TMHILVVHAMVILLT	INTS1	1161	Q8N201
PQMLAHVRTLEMLSL	LRSAM1	166	Q6UWE0
LLVMMSAITVALLSL	ASAH2	16	Q9NR71
MQKIMHISVLLSPVL	GRIA2	1	P42262
RSHHLEMVIQLLAIM	PTGFR	241	P43088
LVIILLMILDHRLHM	OR14K1	41	Q8NGZ2
AHQVLFMMVLSIVLT	OR2T8	21	A6NH00
LDLLKMQMSSLHNII	DNAH8	1656	Q96JB1
AHQVLFMMVLSIVLT	OR2T33	21	Q8NG76
TANLVMILLIHMDSR	OR2T35	41	Q8NGX2
LLTSLMHPNLQTLIM	HECTD4	546	Q9Y4D8
MMLLSAILTLLVTLV	OR6C74	196	A6NCV1
LSLMDLMHVSTIILK	OR2AE1	66	Q8NHA4
AMIHSIEMINNSTLL	GPRC6A	76	Q5T6X5
VMNCHLLILETFLMT	SLC51A	296	Q86UW1
VMSVLHEMLQQIFSL	IFNW1	76	P05000
ILMQLFRVLTNMTHE	DOCK11	871	Q5JSL3
TLVLAYLMIHKDMTL	DUSP29	156	Q68J44
VSHMVKLTLMLLVAG	ADCY3	771	O60266
EISIMTLRMFEHLLQ	FHIP2A	466	Q5W0V3
LVDMTMHLNALNISL	GTF2IRD2	756	Q86UP8
LVDMTMHLNALNISL	GTF2IRD2B	756	Q6EKJ0
QTLHKLEAMMLILQA	PKD1	2686	P98161
IMIHILAGSTLMVSL	OR8H1	196	Q8NGG4
LIMFIVIQVGMALHT	OR6K6	71	Q8NGW6
SLLMNTIMLVVSILL	OR2K2	191	Q8NGT1
FIMATLMTLNTHSLL	MT-ND4L	41	P03901
LMRNSIFQLMIHTLD	SLC24A2	341	Q9UI40
ILHLITMMALKVLGE	TENT5D	321	Q8NEK8
ENQALHPVIMALILM	LINC00862	41	A6NCI5
SRLMMEHVLLVSILH	NOM1	416	Q5C9Z4
AIKILVHSLFSMLIM	SCN3A	121	Q9NY46
LLLLVTMIVNLAMTI	SGCZ	41	Q96LD1
MLMNLISRLVGIHEL	SDAD1	316	Q9NVU7
AIKILVHSLFSMLIM	SCN1A	121	P35498
ISCVFHQMLSVILML	NCAPD3	296	P42695
LMEMQPILNTSLHRV	COL24A1	421	Q17RW2
TMYIALISLHALIMV	ZDHHC3	176	Q9NYG2
DHLILLALMTVVMAV	PTGIR	236	P43119
GLMQMLLLKVSAHIT	TRABD	146	Q9H4I3
MHVEMILIFLCVLVI	RNF175	51	Q8N4F7
ILNHMVSASMITLLL	PIEZO2	1931	Q9H5I5
LITMAHMLQILLTVD	UBR1	1441	Q8IWV7
SILASTLPQHMLQML	TMCO6	231	Q96DC7
MIILSHIYIIIMRLS	TRPM1	1111	Q7Z4N2
LRTMLITHMQDLQEV	SEPTIN2	276	Q15019
MTPQHMEALLQSLVI	SLFN5	521	Q08AF3
LTEEMLLKHLQRMVS	TM7SF3	206	Q9NS93
VEMVCLHVISLMEAL	UNC79	2531	Q9P2D8
HSTIVLTLLMSMFAL	KCNH8	351	Q96L42
IALMNALTVNLHLLM	KYNU	131	Q16719