Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	GABRD PTK2B MAGT1 SLC14A1 SLC47A2 RHAG RYR2 KCNJ11 GABRR3	5.82e-05	758	47	9	GO:0015318
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRD PTK2B RYR2 KCNJ11 GABRR3	8.84e-05	193	47	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRD PTK2B RYR2 KCNJ11 GABRR3	9.73e-05	197	47	5	GO:0022834
GeneOntologyMolecularFunction	channel activity	GABRD PTK2B SLC14A1 RHAG RYR2 KCNJ11 GABRR3	2.11e-04	525	47	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GABRD PTK2B SLC14A1 RHAG RYR2 KCNJ11 GABRR3	2.13e-04	526	47	7	GO:0022803
GeneOntologyMolecularFunction	transmembrane transporter activity	GABRD PTK2B ABCA4 MAGT1 SLC14A1 SLC47A2 RHAG RYR2 KCNJ11 GABRR3	3.48e-04	1180	47	10	GO:0022857
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRD PTK2B GABRR3	4.82e-04	65	47	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRD PTK2B GABRR3	4.82e-04	65	47	3	GO:0022824
GeneOntologyMolecularFunction	transporter activity	GABRD PTK2B ABCA4 MAGT1 SLC14A1 SLC47A2 RHAG RYR2 KCNJ11 GABRR3	6.98e-04	1289	47	10	GO:0005215
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GABRD PTK2B GABRR3	7.91e-04	77	47	3	GO:0005230
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRD GABRR3	9.04e-04	19	47	2	GO:0004890
GeneOntologyMolecularFunction	gated channel activity	GABRD PTK2B RYR2 KCNJ11 GABRR3	1.10e-03	334	47	5	GO:0022836
GeneOntologyMolecularFunction	GABA receptor activity	GABRD GABRR3	1.22e-03	22	47	2	GO:0016917
GeneOntologyMolecularFunction	ankyrin binding	RHAG KCNJ11	1.33e-03	23	47	2	GO:0030506
GeneOntologyMolecularFunction	DNA exonuclease activity, producing 5'-phosphomonoesters	POLE APTX	1.57e-03	25	47	2	GO:0016895
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GABRD PTK2B GABRR3	1.68e-03	100	47	3	GO:0030594
GeneOntologyMolecularFunction	DNA exonuclease activity	POLE APTX	1.70e-03	26	47	2	GO:0004529
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	GABRD PTK2B MAGT1 SLC47A2 RYR2 KCNJ11 GABRR3	2.39e-03	793	47	7	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	PTK2B MAGT1 SLC47A2 RHAG RYR2 KCNJ11	3.36e-03	627	47	6	GO:0022890
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	EPHB4 GABRD OR2AG2 P2RY8 PTK2B OR2B3 GPR153 GABRR3 OR2AG1	3.84e-03	1353	47	9	GO:0004888
GeneOntologyMolecularFunction	epidermal growth factor receptor binding	TNK2 EGF	4.19e-03	41	47	2	GO:0005154
GeneOntologyMolecularFunction	monoatomic ion channel activity	GABRD PTK2B RYR2 KCNJ11 GABRR3	4.35e-03	459	47	5	GO:0005216
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB4 PTK2B TNK2	4.81e-03	145	47	3	GO:0004713
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine kinase activity	PTK2B TNK2	5.25e-03	46	47	2	GO:0004715
Domain	-	SLC14A1 RHAG	1.29e-04	7	47	2	1.10.3430.10
Domain	Ammonium/urea_transptr	SLC14A1 RHAG	1.29e-04	7	47	2	IPR029020
Domain	PRAME_family	PRAMEF6 PRAMEF20	1.03e-03	19	47	2	IPR026271
Domain	TyrKc	EPHB4 PTK2B TNK2	1.41e-03	88	47	3	SM00219
Domain	Tyr_kinase_cat_dom	EPHB4 PTK2B TNK2	1.41e-03	88	47	3	IPR020635
Domain	GABAA/Glycine_rcpt	GABRD GABRR3	1.52e-03	23	47	2	IPR006028
Domain	PROTEIN_KINASE_TYR	EPHB4 PTK2B TNK2	1.87e-03	97	47	3	PS00109
Domain	Tyr_kinase_AS	EPHB4 PTK2B TNK2	1.87e-03	97	47	3	IPR008266
Domain	Pkinase_Tyr	EPHB4 PTK2B TNK2	4.18e-03	129	47	3	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB4 PTK2B TNK2	5.05e-03	138	47	3	IPR001245
Domain	Neurotransmitter_ion_chnl_CS	GABRD GABRR3	5.73e-03	45	47	2	IPR018000
Domain	Neur_chan_memb	GABRD GABRR3	5.98e-03	46	47	2	PF02932
Domain	Neur_chan_LBD	GABRD GABRR3	6.23e-03	47	47	2	PF02931
Domain	NEUROTR_ION_CHANNEL	GABRD GABRR3	6.23e-03	47	47	2	PS00236
Domain	Neurotrans-gated_channel_TM	GABRD GABRR3	6.23e-03	47	47	2	IPR006029
Domain	-	GABRD GABRR3	6.23e-03	47	47	2	2.70.170.10
Domain	Neur_channel	GABRD GABRR3	6.23e-03	47	47	2	IPR006201
Domain	Neur_chan_lig-bd	GABRD GABRR3	6.23e-03	47	47	2	IPR006202
Domain	TBC	TBC1D10B TBC1D10A	6.76e-03	49	47	2	SM00164
Domain	RabGAP-TBC	TBC1D10B TBC1D10A	7.87e-03	53	47	2	PF00566
Domain	TBC_RABGAP	TBC1D10B TBC1D10A	8.46e-03	55	47	2	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D10B TBC1D10A	8.46e-03	55	47	2	IPR000195
Pubmed	The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells †.	TBC1D10B TBC1D10A	1.79e-06	2	47	2	34757852
Pubmed	Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins.	TBC1D10B TBC1D10A	1.79e-06	2	47	2	31527750
Pubmed	DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane.	CLIP3 ZDHHC17	1.79e-06	2	47	2	24001771
Pubmed	Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.	TNK2 EGF	5.36e-06	3	47	2	16316319
Pubmed	Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.	TBC1D10B TBC1D10A	5.36e-06	3	47	2	20404108
Pubmed	A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.	PTK2B TNK2	5.36e-06	3	47	2	8497321
Pubmed	ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.	CLIP3 ZDHHC17	1.07e-05	4	47	2	19139280
Pubmed	The physical and genetic map surrounding the Lyst gene on mouse chromosome 13.	LYST RYR2	1.07e-05	4	47	2	9070932
Pubmed	All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras.	TBC1D10B TBC1D10A	1.07e-05	4	47	2	23248241
Pubmed	Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.	BARD1 LTN1	1.78e-05	5	47	2	27977889
Pubmed	Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor.	PTK2B EGF	2.67e-05	6	47	2	18365874
Pubmed	Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.	CLIP3 ZDHHC17	2.67e-05	6	47	2	26198635
Pubmed	Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.	DUSP26 ABCA4 TM9SF4	4.34e-05	50	47	3	24721909
Pubmed	Genomic analysis of orthologous mouse and human olfactory receptor loci.	OR2AG2 OR2AG1	6.40e-05	9	47	2	11416212
Pubmed	Comparative mapping in the beige-satin region of mouse chromosome 13.	LYST RYR2	7.99e-05	10	47	2	9027500
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	LYST RYR2	1.61e-04	14	47	2	11472062
Pubmed	The protein tyrosine kinase family of the human genome.	EPHB4 PTK2B TNK2	1.97e-04	83	47	3	11114734
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF6 PRAMEF20	2.40e-04	17	47	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF6 PRAMEF20	2.40e-04	17	47	2	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF6 PRAMEF20	2.70e-04	18	47	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF6 PRAMEF20	2.70e-04	18	47	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF6 PRAMEF20	2.70e-04	18	47	2	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF6 PRAMEF20	2.70e-04	18	47	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF6 PRAMEF20	2.70e-04	18	47	2	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF6 PRAMEF20	3.01e-04	19	47	2	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF6 PRAMEF20	3.34e-04	20	47	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF6 PRAMEF20	3.34e-04	20	47	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF6 PRAMEF20	3.34e-04	20	47	2	21425410
Pubmed	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.	TBC1D10B TBC1D10A	3.69e-04	21	47	2	17562788
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF6 PRAMEF20	4.06e-04	22	47	2	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF6 PRAMEF20	4.44e-04	23	47	2	19480014
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	GXYLT1 GANAB	5.26e-04	25	47	2	2283726
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF6 PRAMEF20	5.26e-04	25	47	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF6 PRAMEF20	5.26e-04	25	47	2	12620990
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	BARD1 IRF2BPL LTN1	5.54e-04	118	47	3	19690564
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF6 PRAMEF20	5.69e-04	26	47	2	18500982
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	GXYLT1 GANAB	5.69e-04	26	47	2	8218172
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	TBC1D10B TBC1D10A	6.14e-04	27	47	2	22354992
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF6 PRAMEF20	6.61e-04	28	47	2	25089626
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	TBC1D10B GANAB POLE PRAMEF20 LTN1	7.49e-04	533	47	5	25544563
Pubmed	Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.	PTK2B TNK2	7.59e-04	30	47	2	12522270
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF6 PRAMEF20	7.59e-04	30	47	2	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF6 PRAMEF20	8.64e-04	32	47	2	37889087
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	TNK2 EGF	9.19e-04	33	47	2	18271526
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	EGF SLC14A1 RYR2	9.67e-04	143	47	3	20424473
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	RYR2 KCNJ11	9.75e-04	34	47	2	26378152
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF6 PRAMEF20	1.03e-03	35	47	2	19389355
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ADAMTS19 DUSP26 ABCA4 TBC1D10A TM9SF4 PRAMEF6 PRAMEF20	1.31e-03	1242	47	7	30973865
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRD GABRR3	5.42e-04	19	33	2	563
GeneFamily	PRAME family	PRAMEF6 PRAMEF20	8.70e-04	24	33	2	686
GeneFamily	Olfactory receptors, family 2	OR2AG2 OR2B3 OR2AG1	1.13e-03	113	33	3	149
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	SLC14A1 RHAG	2.07e-03	37	33	2	454
GeneFamily	Ankyrin repeat domain containing	BARD1 CLIP3 ZDHHC17	9.61e-03	242	33	3	403
Disease	Takayasu arteritis	EPHB4 PTK2B OR2B3 MUC21	7.06e-05	148	44	4	EFO_1001857
Disease	prostate cancer (implicated_via_orthology)	MAGT1 POLE	1.11e-03	33	44	2	DOID:10283 (implicated_via_orthology)
Disease	endometrial cancer (is_implicated_in)	EGF POLE	1.33e-03	36	44	2	DOID:1380 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WKAPSSWFIDCVMSF	BARD1	756	Q99728
IWCTWFLDSFSIMSM	ABCA4	696	P78363
LSVSDFWRVMMRVCW	APTX	6	Q7Z2E3
SDTWMFGVTLWEMFT	TNK2	311	Q07912
CQTRWMMTEWTPCSR	ADAMTS19	976	Q8TE59
WTMLPSVAMWAVFLF	P2RY8	181	Q86VZ1
ESEWDFIMCSMLAWL	LTN1	1241	O94822
SFLVDMWYQTEWMLC	NXF3	436	Q9H4D5
MSPRVCWIMVATSWI	OR2AG2	136	A6NM03
MNYWFCLRMAAFSWL	OR2B3	136	O76000
MAARWRFWCVSVTMV	MAGT1	1	Q9H0U3
WEVMSFGERPYWDMS	EPHB4	811	P54760
WFWRRPVSSIAMEMS	MUC21	546	Q5SSG8
TMSFLCSWLLFAMAW	KCNJ11	76	Q14654
RMPWAMIWDFSEPVC	IRF2BPL	21	Q9H1B7
RACSYMRWKMEQWFT	NEMP2	311	A6NFY4
VTSLSYHRMWMVCWP	GPR153	101	Q6NV75
YWMLPSDVCGMNCFW	GXYLT1	86	Q4G148
MPSVLLVAMSWVSFW	GABRD	256	O14764
SFSRCWEFLLWMDPS	POLE	1906	Q07864
MSSRACWLMVATSWI	OR2AG1	136	Q9H205
WPFIVMMDDSCVLWN	GREB1L	1611	Q9C091
MWRESSAACTMSFWY	MALRD1	1586	Q5VYJ5
VAWVKWMDSSAPFTM	DNAH1	2176	Q9P2D7
FPAILMVMLSWVSFW	GABRR3	276	A8MPY1
YVWFSDWAMPSVMRV	EGF	696	P01133
ADIWSMCRWIYMLSS	LYST	961	Q99698
SDVWMFAVCMWEILS	PTK2B	606	Q14289
LLFCCWFPWMLRAEM	CLIP3	531	Q96DZ5
EVILPMLCSYMSRWW	RYR2	3236	Q92736
AMSWVLYLWISACAM	TAFA1	6	Q7Z5A9
VPSMLMICVEWWAYE	SLC47A2	296	Q86VL8
DFTNPTMRAWWANMF	GANAB	511	Q14697
NFWMVWSEAMARRCL	PRAMEF20	111	Q5VT98
TWTANSFWLMPAFML	SPG21	146	Q9NZD8
WLWASMTFMARFSRS	DUSP26	6	Q9BV47
TVIMPTWFCSRAWFS	B3GNTL1	176	Q67FW5
NFWMVWSEAMARGCF	PRAMEF6	111	Q5VXH4
MATAMDWLPWSLLLF	TM9SF4	1	Q92544
CDMMADPWNAFWFCL	PROM2	771	Q8N271
AMIGTLFLWMFWPSF	RHAG	211	Q02094
TEWFMCIFARTLPWA	TBC1D10B	521	Q4KMP7
DYFWWLLLPVCAMSM	SLC14A1	141	Q13336
SMTQALCRMIDWLSW	USP38	266	Q8NB14
ITQIATCSPWMFWMF	ZDHHC17	521	Q8IUH5
TCSPWMFWMFLNSVF	ZDHHC17	526	Q8IUH5
IIGWMWYFTEMVFCS	AGPAT4	131	Q9NRZ5
MTEWFMCAFSRTLPW	TBC1D10A	271	Q9BXI6