Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of dendritic spine morphogenesis	NLGN3 NLGN1	9.19e-05	8	38	2	GO:0061002
GeneOntologyBiologicalProcess	positive regulation of synaptic vesicle clustering	NLGN3 NLGN1	9.19e-05	8	38	2	GO:2000809
GeneOntologyBiologicalProcess	positive regulation of protein localization to synapse	NLGN3 NLGN1	9.19e-05	8	38	2	GO:1902474
GeneOntologyBiologicalProcess	terminal button organization	NLGN3 NLGN1	1.18e-04	9	38	2	GO:0072553
GeneOntologyBiologicalProcess	presynaptic membrane assembly	NLGN3 NLGN1	1.47e-04	10	38	2	GO:0097105
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NLGN3 NLGN1	1.80e-04	11	38	2	GO:0097104
GeneOntologyBiologicalProcess	regulation of synaptic vesicle clustering	NLGN3 NLGN1	2.16e-04	12	38	2	GO:2000807
GeneOntologyBiologicalProcess	presynaptic membrane organization	NLGN3 NLGN1	2.55e-04	13	38	2	GO:0097090
GeneOntologyBiologicalProcess	regulation of respiratory gaseous exchange by nervous system process	NLGN3 NLGN1	2.97e-04	14	38	2	GO:0002087
GeneOntologyBiologicalProcess	circadian behavior	NLGN3 ZFHX3 NLGN1	3.02e-04	71	38	3	GO:0048512
GeneOntologyBiologicalProcess	rhythmic behavior	NLGN3 ZFHX3 NLGN1	3.42e-04	74	38	3	GO:0007622
GeneOntologyBiologicalProcess	meiotic sister chromatid cohesion	REC8 RAD21	3.42e-04	15	38	2	GO:0051177
GeneOntologyBiologicalProcess	negative regulation of G2/M transition of mitotic cell cycle	PKMYT1 FOXO4 RAD21	3.55e-04	75	38	3	GO:0010972
GeneOntologyBiologicalProcess	negative regulation of cell cycle G2/M phase transition	PKMYT1 FOXO4 RAD21	3.84e-04	77	38	3	GO:1902750
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	NLGN3 NLGN1	3.90e-04	16	38	2	GO:0007158
GeneOntologyBiologicalProcess	regulation of respiratory system process	NLGN3 NLGN1	4.42e-04	17	38	2	GO:0044065
GeneOntologyBiologicalProcess	negative regulation of dendritic spine development	NLGN3 NLGN1	4.96e-04	18	38	2	GO:0061000
GeneOntologyBiologicalProcess	regulation of NMDA receptor activity	NLGN3 NLGN1	4.96e-04	18	38	2	GO:2000310
GeneOntologyBiologicalProcess	synaptic vesicle clustering	NLGN3 NLGN1	7.46e-04	22	38	2	GO:0097091
GeneOntologyBiologicalProcess	regulation of AMPA receptor activity	NLGN3 NLGN1	9.65e-04	25	38	2	GO:2000311
GeneOntologyBiologicalProcess	regulation of respiratory gaseous exchange	NLGN3 NLGN1	1.13e-03	27	38	2	GO:0043576
GeneOntologyBiologicalProcess	inhibitory postsynaptic potential	NLGN3 NLGN1	1.13e-03	27	38	2	GO:0060080
GeneOntologyBiologicalProcess	regulation of G2/M transition of mitotic cell cycle	PKMYT1 FOXO4 RAD21	1.27e-03	116	38	3	GO:0010389
GeneOntologyCellularComponent	meiotic cohesin complex	REC8 RAD21	6.72e-05	7	38	2	GO:0030893
GeneOntologyCellularComponent	cohesin complex	REC8 RAD21	1.75e-04	11	38	2	GO:0008278
Domain	COesterase	CES3 NLGN3 NLGN1	2.16e-06	14	35	3	PF00135
Domain	CARBOXYLESTERASE_B_2	CES3 NLGN3 NLGN1	2.16e-06	14	35	3	PS00941
Domain	CarbesteraseB	CES3 NLGN3 NLGN1	2.16e-06	14	35	3	IPR002018
Domain	Rad21/Rec8_C_eu	REC8 RAD21	1.02e-05	3	35	2	IPR006909
Domain	Rad21_Rec8_N	REC8 RAD21	1.02e-05	3	35	2	IPR006910
Domain	-	REC8 RAD21	1.02e-05	3	35	2	1.10.10.580
Domain	Rad21/Rec8_C	REC8 RAD21	1.02e-05	3	35	2	IPR023093
Domain	Rad21_Rec8_N	REC8 RAD21	1.02e-05	3	35	2	PF04825
Domain	Rad21_Rec8	REC8 RAD21	1.02e-05	3	35	2	PF04824
Domain	Nlgn	NLGN3 NLGN1	3.40e-05	5	35	2	IPR000460
Domain	Carboxylesterase_B_CS	NLGN3 NLGN1	2.63e-04	13	35	2	IPR019819
Domain	PI3Kc	TRRAP PIK3C2G	4.03e-04	16	35	2	SM00146
Domain	-	TRRAP PIK3C2G	4.03e-04	16	35	2	1.10.1070.11
Domain	PI3_4_KINASE_1	TRRAP PIK3C2G	5.12e-04	18	35	2	PS00915
Domain	PI3_4_KINASE_2	TRRAP PIK3C2G	5.12e-04	18	35	2	PS00916
Domain	PI3/4_kinase_cat_dom	TRRAP PIK3C2G	5.12e-04	18	35	2	IPR000403
Domain	PI3_PI4_kinase	TRRAP PIK3C2G	5.12e-04	18	35	2	PF00454
Domain	PI3_4_KINASE_3	TRRAP PIK3C2G	5.12e-04	18	35	2	PS50290
Domain	-	CES3 NLGN3 NLGN1	1.42e-03	119	35	3	3.40.50.1820
Domain	AB_hydrolase	CES3 NLGN3 NLGN1	1.42e-03	119	35	3	IPR029058
Domain	WHTH_DNA-bd_dom	REC8 FOXO4 RAD21	1.04e-02	242	35	3	IPR011991
Pubmed	Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism.	NLGN3 NLGN1	1.16e-06	2	38	2	25592157
Pubmed	α-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells.	REC8 RAD21	1.16e-06	2	38	2	36571142
Pubmed	Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism.	NLGN3 NLGN1	1.16e-06	2	38	2	22983708
Pubmed	Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3.	NLGN3 NLGN1	1.16e-06	2	38	2	35992071
Pubmed	Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia.	NLGN3 NLGN1	1.16e-06	2	38	2	11329178
Pubmed	Characterization of the neuroligin gene family expression and evolution in zebrafish.	NLGN3 NLGN1	1.16e-06	2	38	2	20034102
Pubmed	Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice.	REC8 RAD21	1.16e-06	2	38	2	12130806
Pubmed	Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans.	REC8 RAD21	1.16e-06	2	38	2	10207075
Pubmed	Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses.	NLGN3 NLGN1	3.48e-06	3	38	2	35704570
Pubmed	Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.	REC8 RAD21	3.48e-06	3	38	2	20971813
Pubmed	Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.	REC8 RAD21	3.48e-06	3	38	2	24291092
Pubmed	Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.	NLGN3 NLGN1	3.48e-06	3	38	2	26291161
Pubmed	Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.	NLGN3 NLGN1	3.48e-06	3	38	2	28607166
Pubmed	Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.	NLGN3 NLGN1	3.48e-06	3	38	2	29100073
Pubmed	Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses.	NLGN3 NLGN1	3.48e-06	3	38	2	17897391
Pubmed	Neuroligins determine synapse maturation and function.	NLGN3 NLGN1	3.48e-06	3	38	2	16982420
Pubmed	Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.	NLGN3 NLGN1	3.48e-06	3	38	2	27217145
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PSMC2 FLNC RBM25 TRRAP ZMYM3 TASOR2 RAD21	6.06e-06	653	38	7	22586326
Pubmed	Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.	NLGN3 NLGN1	6.96e-06	4	38	2	21788371
Pubmed	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry.	NLGN3 NLGN1	6.96e-06	4	38	2	32719346
Pubmed	Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.	BCL9 TRRAP	6.96e-06	4	38	2	18347063
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN3 NLGN1	6.96e-06	4	38	2	16077734
Pubmed	Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes.	REC8 RAD21	6.96e-06	4	38	2	32328639
Pubmed	Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.	NLGN3 NLGN1	6.96e-06	4	38	2	30056576
Pubmed	Cleaved high molecular weight kininogen stimulates JNK/FOXO4/MnSOD pathway for induction of endothelial progenitor cell senescence.	FOXO4 KNG1	6.96e-06	4	38	2	24984152
Pubmed	5-HT modulation of a medial septal circuit tunes social memory stability.	NLGN3 NLGN1	1.16e-05	5	38	2	34616037
Pubmed	Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.	NLGN3 NLGN1	1.16e-05	5	38	2	27581450
Pubmed	Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.	NLGN3 NLGN1	1.16e-05	5	38	2	15620359
Pubmed	Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures.	NLGN3 NLGN1	1.16e-05	5	38	2	28939043
Pubmed	STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.	REC8 RAD21	1.16e-05	5	38	2	12034751
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN3 NLGN1	1.16e-05	5	38	2	10996085
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN3 NLGN1	1.16e-05	5	38	2	37865312
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN3 NLGN1	1.74e-05	6	38	2	29724786
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN3 NLGN1	1.74e-05	6	38	2	21838267
Pubmed	Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.	NLGN3 NLGN1	1.74e-05	6	38	2	29742426
Pubmed	Structures, alternative splicing, and neurexin binding of multiple neuroligins.	NLGN3 NLGN1	1.74e-05	6	38	2	8576240
Pubmed	Human transcription factor protein interaction networks.	TRERF1 PSMC2 ZFHX3 RBM25 LHX8 BCL9 TRRAP ZMYM3 RAD21	1.80e-05	1429	38	9	35140242
Pubmed	Cohesin Smc1beta determines meiotic chromatin axis loop organization.	REC8 RAD21	2.43e-05	7	38	2	18180366
Pubmed	UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.	NLGN3 NLGN1	3.24e-05	8	38	2	30201312
Pubmed	Control of excitatory and inhibitory synapse formation by neuroligins.	NLGN3 NLGN1	3.24e-05	8	38	2	15681343
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN3 NLGN1	3.24e-05	8	38	2	30871858
Pubmed	The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility.	REC8 RAD21	4.16e-05	9	38	2	21743440
Pubmed	Molecular self-avoidance in synaptic neurexin complexes.	NLGN3 NLGN1	4.16e-05	9	38	2	34919427
Pubmed	Binding of neuroligins to PSD-95.	NLGN3 NLGN1	4.16e-05	9	38	2	9278515
Pubmed	RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.	REC8 RAD21	5.20e-05	10	38	2	21242291
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN3 NLGN1	6.35e-05	11	38	2	32973045
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	FLNC TRRAP	6.35e-05	11	38	2	24349473
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN3 NLGN1	6.35e-05	11	38	2	26403076
Pubmed	A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.	REC8 RAD21	7.62e-05	12	38	2	21274006
Pubmed	Meiotic cohesin complexes are essential for the formation of the axial element in mice.	REC8 RAD21	7.62e-05	12	38	2	22711701
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	PSMC2 FLNC TRRAP	8.01e-05	76	38	3	27542412
Pubmed	A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.	DAAM1 TET3	9.00e-05	13	38	2	26989192
Pubmed	Translational animal models of autism and neurodevelopmental disorders.	NLGN3 NLGN1	1.05e-04	14	38	2	23226954
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN3 NLGN1	1.21e-04	15	38	2	18227507
Pubmed	Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I.	REC8 LHX8	1.21e-04	15	38	2	28504655
Pubmed	Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.	NLGN3 NLGN1	1.76e-04	18	38	2	18854036
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	NLGN3 NLGN1	1.76e-04	18	38	2	28864826
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TRERF1 RBM25 BCL9 MAP1S TRRAP ZMYM3	1.79e-04	774	38	6	15302935
Pubmed	Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.	REC8 BOLL	1.96e-04	19	38	2	29941866
Pubmed	Functional genomics identifies therapeutic targets for MYC-driven cancer.	PSMC2 TRRAP RAD21	1.97e-04	103	38	3	22623531
Pubmed	STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.	REC8 RAD21	2.18e-04	20	38	2	24797475
Pubmed	Meiosis in mice without a synaptonemal complex.	REC8 RAD21	2.65e-04	22	38	2	22164254
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	PSMC2 TRRAP	3.43e-04	25	38	2	36708875
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	NLGN3 NLGN1	3.72e-04	26	38	2	34848499
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	FOXO4 ZFHX3 LHX8	3.91e-04	130	38	3	19386638
Pubmed	Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.	REC8 LHX8	4.32e-04	28	38	2	19014927
Pubmed	Specification of jaw identity by the Hand2 transcription factor.	ZFHX3 LHX8	4.32e-04	28	38	2	27329940
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	NLGN3 NLGN1	4.96e-04	30	38	2	16186258
Pubmed	Interaction network of human early embryonic transcription factors.	TRERF1 ZFHX3 BCL9 ZMYM3	5.74e-04	351	38	4	38297188
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	ZFHX3 TRRAP	7.97e-04	38	38	2	28218735
Pubmed	Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.	FLNC ADGRG2	8.40e-04	39	38	2	24703692
Pubmed	Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.	TRRAP RAD21	9.74e-04	42	38	2	29028833
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PKMYT1 KIAA1549 EMC3 DAAM1 RPP25L PDHX RAD21	1.01e-03	1487	38	7	33957083
Cytoband	Xq13.1	NLGN3 FOXO4 ZMYM3	8.82e-06	48	38	3	Xq13.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq13	NLGN3 FOXO4 ZMYM3	3.51e-04	165	38	3	chrXq13
GeneFamily	Cohesin complex	REC8 RAD21	3.58e-05	8	21	2	1060
GeneFamily	RNA binding motif containing	RBM25 BOLL	2.50e-02	213	21	2	725
Disease	Schizoaffective disorder-bipolar type	PKMYT1 RAD21	1.92e-04	16	38	2	EFO_0009965
Disease	melanoma	PKMYT1 REC8 SLC35G2 TRRAP	2.87e-04	248	38	4	C0025202
Disease	age-related hearing impairment	PSMC2 TMPRSS9 NLGN1 BAIAP2L2	7.85e-04	324	38	4	EFO_0005782
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN3 TMPRSS9 NLGN1	9.91e-04	152	38	3	DOID:0060041 (implicated_via_orthology)
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	SLC35G2 KNG1	2.38e-03	56	38	2	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	hearing loss	TMPRSS9 BAIAP2L2	3.39e-03	67	38	2	EFO_0004238
Disease	Autistic Disorder	NLGN3 NLGN1 TRRAP	4.59e-03	261	38	3	C0004352
Disease	Autism Spectrum Disorders	NLGN3 TET3	5.39e-03	85	38	2	C1510586

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAITMPAPVMQPEPI	BOLL	261	Q8N9W6
IDMPPQSETISSPMP	ADGRG2	316	Q8IZP9
VPELPEVPMEMPLVL	REC8	456	O95072
EVPMEMPLVLPPELE	REC8	461	O95072
PVPMSIMAPAPTVLV	RBM25	41	P49756
DSPDSVDPVEPMPTM	RAD21	276	O60216
SMTLQSEPPVEMITP	PIK3C2G	596	O75747
PREALEPMLTPSLPM	KIAA1549	186	Q9HCM3
DPSSICMVDPEMLPP	MAP1S	836	Q66K74
EEGPVNPMTPVTPMT	BAIAP2L2	386	Q6UXY1
SSPMTGPMEQPPEEE	HARBI1	311	Q96MB7
SLVPTLSMIAPPPVM	FOXO4	426	P98177
PIKILMPSLSPTMEE	PDHX	56	O00330
PVVPVEPMESMLRPF	FLNC	1771	Q14315
AVPPSRLSPPMLEEM	LHX8	296	Q68G74
DDVPLMTPNTITMIP	NLGN1	811	Q8N2Q7
DDIPLMTPNTITMIP	NLGN3	801	Q9NZ94
MEPALPMPPVEELDV	DAAM1	41	Q9Y4D1
PPEPTLSQNPLSIMM	BCL9	996	O00512
TMMPPISPAPIQSDD	KNG1	571	P01042
PDIIITPPTPTGMML	C16orf74	36	Q96GX8
VPPSPMTDPTMLTDM	EMC3	96	Q9P0I2
PVLTSLDVPPEMMPT	CES3	376	Q6UWW8
MEEIPPRIPPEMIDT	FAM162B	86	Q5T6X4
IPLPPKIDPTVTMMQ	PSMC2	151	P35998
PITLEIMPCPMLLPS	UBOX5	266	O94941
TMDTLPPPTEDPMIN	SLC35G2	71	Q8TBE7
MMETERLVLPPPDPL	SKIV2L	1	Q15477
MPLETPQALPPMLVH	TRPT1	116	Q86TN4
VPVPHTSPIPEMEAM	C11orf24	306	Q96F05
MLERPPALAMPMPTE	PKMYT1	1	Q99640
SPMPQLPPDTLEMRV	RPP25L	16	Q8N5L8
ILEIMSSQPLPMSPP	TMPRSS9	731	Q7Z410
LLPPTQEMRSPSPMT	TET3	676	O43151
LTSMMSVEEPLPRPL	ZNF818P	6	Q6ZRF7
PLPVSLPSDKTMVME	TASOR2	1146	Q5VWN6
ENTVPPPEMVGMITT	TRRAP	181	Q9Y4A5
SMPIPVPVPMFLPTT	ZMYM3	891	Q14202
PSVPLTQLSMPMELP	ZFHX3	2081	Q15911
QLPPEAESLTPMVMP	TRERF1	571	Q96PN7
AESLTPMVMPVSVPV	TRERF1	576	Q96PN7