Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	2.34e-05	4	40	2	GO:0001602
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	2.13e-04	11	40	2	GO:0004983
Domain	NPY4_rcpt	NPY4R2 NPY4R	3.82e-06	2	37	2	IPR001933
Domain	Sec23/24_helical_dom	SEC23B SEC24B	5.70e-05	6	37	2	IPR006900
Domain	Sec23/24_trunk_dom	SEC23B SEC24B	5.70e-05	6	37	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC23B SEC24B	5.70e-05	6	37	2	IPR006895
Domain	Sec23_24_beta_S	SEC23B SEC24B	5.70e-05	6	37	2	IPR012990
Domain	zf-Sec23_Sec24	SEC23B SEC24B	5.70e-05	6	37	2	PF04810
Domain	Sec23_trunk	SEC23B SEC24B	5.70e-05	6	37	2	PF04811
Domain	Sec23_helical	SEC23B SEC24B	5.70e-05	6	37	2	PF04815
Domain	Sec23_BS	SEC23B SEC24B	5.70e-05	6	37	2	PF08033
Domain	NPY_rcpt	NPY4R2 NPY4R	1.36e-04	9	37	2	IPR000611
Domain	Gelsolin	SEC23B SEC24B	3.42e-04	14	37	2	PF00626
Domain	Gelsolin-like_dom	SEC23B SEC24B	3.42e-04	14	37	2	IPR007123
Domain	-	SEC23B SEC24B	1.03e-03	24	37	2	3.40.20.10
Domain	ADF-H/Gelsolin-like_dom	SEC23B SEC24B	1.03e-03	24	37	2	IPR029006
Domain	-	SEPSECS AGXT	2.70e-03	39	37	2	3.40.640.10
Domain	PDZ	GRIP2 RIMS1 PTPN13	2.71e-03	141	37	3	PF00595
Domain	PyrdxlP-dep_Trfase	SEPSECS AGXT	2.98e-03	41	37	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	SEPSECS AGXT	2.98e-03	41	37	2	IPR015421
Domain	PDZ	GRIP2 RIMS1 PTPN13	3.11e-03	148	37	3	SM00228
Domain	-	GRIP2 RIMS1 PTPN13	3.23e-03	150	37	3	2.30.42.10
Domain	PDZ	GRIP2 RIMS1 PTPN13	3.29e-03	151	37	3	PS50106
Domain	PDZ	GRIP2 RIMS1 PTPN13	3.35e-03	152	37	3	IPR001478
Domain	-	SEC23B SEC24B	9.43e-03	74	37	2	3.40.50.410
Pathway	KEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION	SEC23B SEC24B	2.66e-04	12	29	2	M47770
Pathway	REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT	ANK3 TRAPPC9 ACTR10 SEC24B	2.76e-04	156	29	4	M27097
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	3.87e-06	3	40	2	8643460
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PLK2 PTPN13 HIVEP1 RGL2 UTRN TRAPPC9 SEC23B SEC24B	5.21e-06	861	40	8	36931259
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CHD9 SLITRK3 RIMS1 PTPN13 LRBA ZSWIM1 ANK3 UTRN TRAPPC9 HECTD4	5.25e-06	1489	40	10	28611215
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	7.73e-06	4	40	2	7592911
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PTPN13 LRBA ANK3 UTRN SEC24B	1.26e-05	263	40	5	34702444
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	1.29e-05	5	40	2	7493937
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	EXOC5 SEPSECS PTPN13 HEATR1 ANK3 CHPF TRAPPC9 ACTR10 SEC24B	1.51e-05	1321	40	9	27173435
Pubmed	Sec24 proteins and sorting at the endoplasmic reticulum.	SEC23B SEC24B	1.93e-05	6	40	2	10075675
Pubmed	A family of mammalian proteins homologous to yeast Sec24p.	SEC23B SEC24B	1.93e-05	6	40	2	10329445
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	GRIP2 RIMS1 LRBA RGL2 SEC24B	3.68e-05	329	40	5	17474147
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	EXOC5 CCDC168 PTPN13 CHPF	4.19e-05	168	40	4	30631154
Pubmed	Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.	ANK3 UTRN	7.05e-05	11	40	2	10995443
Pubmed	Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.	SEC23B SEC24B	7.05e-05	11	40	2	19966784
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PRR14L PTPN13 HEATR1 LRBA UTRN GART SEC24B	8.47e-05	934	40	7	33916271
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CHD9 PLK2 PTPN13 LRBA ANK3 CHPF UTRN HECTD4	9.11e-05	1285	40	8	35914814
Pubmed	Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.	EXOC5 LRBA SEC23B GART	1.28e-04	224	40	4	32941674
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	LRBA UTRN SEC23B GART SEC24B	1.59e-04	449	40	5	31732153
Pubmed	The ULK1-FBXW5-SEC23B nexus controls autophagy.	SEC23B SEC24B	2.42e-04	20	40	2	30596474
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	PTPN13 LRBA ANK3 NDRG3 SEC23B SEC24B	2.45e-04	777	40	6	35844135
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	NPY4R TRAPPC9 SEC23B SEC24B	2.83e-04	276	40	4	28319085
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	SEC23B SEC24B	2.94e-04	22	40	2	35120648
Pubmed	A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation.	DHX36 SOHLH2	3.80e-04	25	40	2	25611385
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	HEATR1 ANK3 UTRN SEC23B GART SEC24B	3.81e-04	844	40	6	25963833
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PTPN13 HEATR1 LRBA ANK3 SEC24B	4.01e-04	549	40	5	38280479
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	RIMS1 ANK3 NDRG3	4.35e-04	128	40	3	30995482
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	RIMS1 LRBA	4.45e-04	27	40	2	19723784
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	SEC23B SEC24B	5.87e-04	31	40	2	22323290
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	PTPN13 ANK3	7.49e-04	35	40	2	37381005
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	RIMS1 PTPN13	7.49e-04	35	40	2	33864728
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX36 HEATR1 UTRN SEC23B GART	8.78e-04	653	40	5	22586326
Pubmed	Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system.	ACTR10 COQ9	8.83e-04	38	40	2	18407958
Interaction	STYK1 interactions	PTPN13 HEATR1 LRBA SEC23B SEC24B	1.41e-05	161	39	5	int:STYK1
Interaction	YWHAH interactions	RIMS1 PTPN13 HIVEP1 LRBA RGL2 UTRN TRAPPC9 SEC23B SEC24B HECTD4	3.41e-05	1102	39	10	int:YWHAH
Interaction	EPHB2 interactions	PTPN13 LRBA ANK3 SEC23B SEC24B	5.78e-05	216	39	5	int:EPHB2
Cytoband	2q35	CHPF UNC80	2.19e-03	79	40	2	2q35
GeneFamily	PDZ domain containing	GRIP2 RIMS1 PTPN13	5.11e-04	152	19	3	1220
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLITRK3 ANK3 UNC80 HPS6	2.30e-05	186	40	4	adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 LRBA ANK3 UTRN	2.45e-05	189	40	4	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HEATR1 LRBA ANK3 UTRN	2.50e-05	190	40	4	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 CHPF UNC80 SEC23B	2.66e-05	193	40	4	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 CHPF UNC80 SEC23B	2.66e-05	193	40	4	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 CHPF UNC80 SEC23B	2.71e-05	194	40	4	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MXRA5 PTPN13 LRBA ANK3	2.71e-05	194	40	4	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MXRA5 PTPN13 LRBA ANK3	2.71e-05	194	40	4	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 CHPF UNC80 SEC23B	2.71e-05	194	40	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DHX36 LRBA ANK3 UTRN	2.88e-05	197	40	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 LRBA ANK3 TRAPPC9	2.94e-05	198	40	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	PTPN13 ANK3 CHPF SEC23B	2.94e-05	198	40	4	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	LRBA ANK3 UTRN TRAPPC9	3.00e-05	199	40	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Disease	alcohol drinking	EXOC5 HEATR1 HECTD4	1.57e-04	81	38	3	EFO_0004329
Disease	third ventricle volume measurement	ANK3 HPS6	1.68e-04	15	38	2	EFO_0010335
Disease	autism spectrum disorder (implicated_via_orthology)	CHD9 RIMS1 LRBA	9.91e-04	152	38	3	DOID:0060041 (implicated_via_orthology)
Disease	fibrinogen measurement, tissue plasminogen activator measurement	CHD9 HECTD4	1.54e-03	45	38	2	EFO_0004623, EFO_0004791
Disease	heel bone mineral density, urate measurement	NPY4R2 NPY4R UTRN	1.66e-03	182	38	3	EFO_0004531, EFO_0009270
Disease	peripheral arterial disease, traffic air pollution measurement	RIMS1 LRBA UTRN	1.99e-03	194	38	3	EFO_0004265, EFO_0007908
Disease	Ischemic stroke, fibrinogen measurement	CHD9 HECTD4	2.30e-03	55	38	2	EFO_0004623, HP_0002140
Disease	venous thromboembolism, fibrinogen measurement	CHD9 HECTD4	3.39e-03	67	38	2	EFO_0004286, EFO_0004623
Disease	mean arterial pressure	PLK2 LRBA AGXT HECTD4	3.78e-03	499	38	4	EFO_0006340
Disease	Manic Disorder	RIMS1 ANK3	3.79e-03	71	38	2	C0024713
Disease	Manic	RIMS1 ANK3	4.56e-03	78	38	2	C0338831
Disease	Depression, Bipolar	RIMS1 ANK3	4.67e-03	79	38	2	C0005587

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLELLLHISSPLTPA	ADM5	126	C9JUS6
PSVLLAPSHLMALLT	ACTR10	116	Q9NZ32
LAEMLPPVLTHLSLK	NDRG3	116	Q9UGV2
MNTSHLLALLLPKSP	NPY4R	1	P50391
MLHCISSLPSKLPVT	ALOXE3	286	Q9BYJ1
LMSLPTKISRCPHLL	NCF1	101	P14598
ALKPMHSLIPLGKSA	LRBA	1471	P50851
HLLPVLLTSLMHPNL	HECTD4	541	Q9Y4D8
KTLPPKMPLLQSSSH	RIMS1	1046	Q86UR5
NDHLMPLISSSPKLS	EXOC5	501	O00471
MLLTPGLNLHIPTLS	CHD9	2806	Q3L8U1
SDKFLIIPLHSLMPT	DHX36	516	Q9H2U1
KPNLFSMLLTDPHLA	FMO1	446	Q01740
PILSKTKNGLSPLHM	ANK3	326	Q12955
ILMLPHNIPSSLSLL	COQ9	206	O75208
TSLMLSLNHPLAPVR	HEATR1	481	Q9H583
LPITLHSLSASMPIL	CCDC168	3536	Q8NDH2
LATLLPMLHTESALP	ENPP7	406	Q6UWV6
LLLPTPLEMHKVTLH	GRIP2	931	Q9C0E4
ILQGHLPPSALLTML	HPS6	441	Q86YV9
QHSALMAPSSLKLFP	SEC24B	1061	O95487
MLPHLLPDITLTCNK	PTPN13	1876	Q12923
LPTDSLLHLNKEMPL	PRR14L	666	Q5THK1
LTLILNPLTKHMAYP	MT-ND4	246	P03905
SSQLSPLDLHPSLKM	UTRN	2756	P46939
TTPAPLLTRLAQHMK	RGL2	561	O15211
MASHKLLVTPPKALL	AGXT	1	P21549
LEMSSPQLIKTHLPS	SULT1C3	106	Q6IMI6
PMLPTNLFKAVSLTH	SLITRK3	186	O94933
ALKESLQMSLSLLPP	SEC23B	146	Q15437
APSPLRLMDLLSKKH	CHPF	591	Q8IZ52
MSLSPAPLSLLIKAA	UNC80	1566	Q8N2C7
MNTSHLLALLLPKSP	NPY4R2	1	P0DQD5
MLNIHPSLLPSFKGS	GART	911	P22102
TPHNPISLAMTLKTL	SEPSECS	366	Q9HD40
LNLPASLRPHKMKSL	TRAPPC9	546	Q96Q05
SSLLAPAKHLIASML	PLK2	301	Q9NYY3
NGLLIKDSSPPMLLH	ZSWIM1	36	Q9BR11
SIHLPSAMPPVSKLL	SOHLH2	386	Q9NX45
LPTKLIDSMSNSHPL	HIVEP1	1601	P15822
RLSSTTIPLPLHMSK	MXRA5	1666	Q9NR99