Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LDLR LRP8 LRP1 LRP6	5.47e-06	16	152	4	GO:0005041
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL12A1 VWF LAMB1 SSPOP TINAGL1 POMZP3 FBN2 HMCN2 MUC2	1.42e-05	188	152	9	GO:0005201
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LDLR LRP8 LRP1 LRP6	1.75e-05	21	152	4	GO:0030228
GeneOntologyMolecularFunction	coreceptor activity	ITGA4 GFRA4 CD22 LRP1 LRP6 LRP5	1.82e-05	72	152	6	GO:0015026
GeneOntologyMolecularFunction	aminoacyltransferase activity	MED20 RNF31 CBLC RNF183 RNF187 DDB2 TRIM33 TGM1 RNF123 ZNF451 MARCHF5 UHRF1 FBXW11	2.21e-04	532	152	13	GO:0016755
GeneOntologyMolecularFunction	very-low-density lipoprotein particle receptor activity	LDLR LRP8	3.42e-04	4	152	2	GO:0030229
GeneOntologyMolecularFunction	apolipoprotein binding	LRP8 LRP1 LRP6	4.48e-04	20	152	3	GO:0034185
GeneOntologyMolecularFunction	cargo receptor activity	MRC1 LDLR LRP8 LRP1 LRP6	4.81e-04	85	152	5	GO:0038024
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	MED20 RNF31 CBLC RNF183 RNF187 DDB2 TRIM33 RNF123 ZNF451 MARCHF5 UHRF1 FBXW11	5.62e-04	512	152	12	GO:0019787
GeneOntologyMolecularFunction	cupric ion binding	ATP13A2 MUC2	5.67e-04	5	152	2	GO:1903135
GeneOntologyMolecularFunction	calcium ion binding	CBLC PLCD4 CASR ADGRE2 LDLR LRP8 JAG2 CDH24 FBN2 HMCN2 MEGF8 JAG1 LRP1 ASTN2 NOTCH3	6.08e-04	749	152	15	GO:0005509
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	MED20 RNF31 CBLC RNF183 TRIM33 RNF123 ZNF451 MARCHF5 UHRF1 FBXW11	9.65e-04	398	152	10	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	MED20 RNF31 CBLC RNF183 RNF187 DDB2 TRIM33 RNF123 MARCHF5 UHRF1 FBXW11	1.02e-03	473	152	11	GO:0004842
GeneOntologyBiologicalProcess	regulation of lysosomal protein catabolic process	ATP13A2 LDLR LRP1 MFSD8	1.34e-06	12	152	4	GO:1905165
GeneOntologyBiologicalProcess	regulation of protein catabolic process in the vacuole	ATP13A2 LDLR LRP1 MFSD8	2.68e-06	14	152	4	GO:1904350
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	SHANK1 SEMA4F TRIO NTRK3 ADGRB1 LAMB1 ITGA4 BTBD3 LRP8 HMCN2 MEGF8 SEMA5B LRP1 LGR6 STRC PLXNA1 NOTCH3 STRCP1	1.04e-05	748	152	18	GO:0048667
GeneOntologyBiologicalProcess	lysosomal protein catabolic process	ATP13A2 LDLR LRP1 MFSD8	2.69e-05	24	152	4	GO:1905146
GeneOntologyBiologicalProcess	protein catabolic process in the vacuole	ATP13A2 LDLR LRP1 MFSD8	5.06e-05	28	152	4	GO:0007039
GeneOntologyBiologicalProcess	neuron projection guidance	SEMA4F TRIO LAMB1 HMCN2 MEGF8 SEMA5B LRP1 LGR6 PLXNA1 NOTCH3	5.34e-05	286	152	10	GO:0097485
GeneOntologyBiologicalProcess	positive regulation of axon extension involved in regeneration	NTRK3 LRP1	5.40e-05	2	152	2	GO:0048691
GeneOntologyBiologicalProcess	cell morphogenesis	SHANK1 SEMA4F TRIO NTRK3 ADGRB1 LAMB1 ITGA4 BTBD3 LRP8 CDH24 HMCN2 MEGF8 SEMA5B IGHM PKHD1 LRP1 LRP6 LGR6 STRC PLXNA1 NOTCH3 STRCP1	6.51e-05	1194	152	22	GO:0000902
GeneOntologyBiologicalProcess	mechanoreceptor differentiation	NTRK3 JAG2 OTOGL JAG1 STRC STRCP1	1.22e-04	104	152	6	GO:0042490
GeneOntologyBiologicalProcess	positive regulation of sprouting of injured axon	NTRK3 LRP1	1.61e-04	3	152	2	GO:0048687
GeneOntologyBiologicalProcess	neuron development	SHANK1 CFH SEMA4F TRIO NTRK3 ZMYND8 ADGRB1 LAMB1 ITGA4 BTBD3 LRP8 HMCN2 MEGF8 SEMA5B OTOGL TENM1 LRP1 LRP6 MFSD8 LGR6 STRC PLXNA1 NOTCH3 STRCP1	1.78e-04	1463	152	24	GO:0048666
GeneOntologyCellularComponent	extracellular matrix	ADAMTSL1 COL12A1 VWF COL20A1 LAMB1 RTBDN SSPOP TINAGL1 POMZP3 FBN2 FCGBP HMCN2 OTOGL ADAMTS18 ADAMTS20 LGR6 MUC2 ADAMTSL2	1.41e-06	656	152	18	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTSL1 COL12A1 VWF COL20A1 LAMB1 RTBDN SSPOP TINAGL1 POMZP3 FBN2 FCGBP HMCN2 OTOGL ADAMTS18 ADAMTS20 LGR6 MUC2 ADAMTSL2	1.47e-06	658	152	18	GO:0030312
GeneOntologyCellularComponent	cell surface	CFH MRC1 VWF LAYN CASR RTBDN ITGA4 GFRA4 ADGRE2 LDLR LRP8 CD14 CD22 MRC2 IGHM PKHD1 LRP1 LRP6 ASTN1 STRC NOTCH3 STRCP1 GP2	5.53e-06	1111	152	23	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	CFH VWF RTBDN ITGA4 GFRA4 ADGRE2 LDLR CD14 CD22 IGHM PKHD1 LRP1 ASTN1 GP2	2.70e-05	519	152	14	GO:0009897
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ADAMTSL1 COL12A1 VWF COL20A1 LAMB1 RTBDN SSPOP TINAGL1 POMZP3 FBN2 HMCN2 ADAMTS20 MUC2	1.37e-04	530	152	13	GO:0062023
GeneOntologyCellularComponent	striated muscle myosin thick filament	OBSCN MYBPC3	3.12e-04	4	152	2	GO:0005863
GeneOntologyCellularComponent	receptor complex	RNF31 TAS1R3 NTRK3 ITGA4 GFRA4 LDLR LRP8 CD14 IGHM LRP1 LRP5 PLXNA1 NOTCH3	3.33e-04	581	152	13	GO:0043235
GeneOntologyCellularComponent	apolipoprotein B mRNA editing enzyme complex	APOBEC1 APOBEC3F	5.18e-04	5	152	2	GO:0030895
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	LRP6 LRP5	5.18e-04	5	152	2	GO:1990851
GeneOntologyCellularComponent	somatodendritic compartment	SHANK1 CFH PCSK5 SEMA4F AGO2 ERO1A ZMYND8 ADGRB1 CASR ITGA4 ATP13A2 LDLR LRP8 HMCN2 CD22 LRP1 LRP6 ASTN1 ASTN2 FBXW11	5.99e-04	1228	152	20	GO:0036477
GeneOntologyCellularComponent	mRNA editing complex	APOBEC1 APOBEC3F	1.08e-03	7	152	2	GO:0045293
Domain	EGF_1	LAMB1 ADGRE2 SSPOP LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 NTN5 TENM1 LRP1 LRP6 LRP5 ASTN1 ASTN2 C6 NOTCH3 GP2	2.33e-14	255	152	20	PS00022
Domain	EGF_2	LAMB1 ADGRE2 SSPOP LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 NTN5 TENM1 LRP1 LRP6 LRP5 ASTN1 ASTN2 C6 NOTCH3 GP2	4.84e-14	265	152	20	PS01186
Domain	EGF-like_dom	PCSK5 LAMB1 ADGRE2 LDLR LRP8 JAG2 FBN2 FCGBP HMCN2 MEGF8 JAG1 TENM1 LRP1 LRP6 LRP5 ASTN1 C6 NOTCH3 GP2	1.78e-13	249	152	19	IPR000742
Domain	EGF_3	ADGRE2 SSPOP LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 TENM1 LRP1 LRP6 LRP5 ASTN1 ASTN2 C6 NOTCH3 GP2	7.51e-13	235	152	18	PS50026
Domain	EGF-like_CS	LAMB1 ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 TENM1 LRP1 LRP6 LRP5 ASTN1 C6 NOTCH3 GP2	4.47e-11	261	152	17	IPR013032
Domain	EGF	PCSK5 LAMB1 ADGRE2 LDLR LRP8 JAG2 FBN2 FCGBP MEGF8 JAG1 TENM1 LRP1 LRP6 LRP5 ASTN1 NOTCH3	8.90e-11	235	152	16	SM00181
Domain	EGF_CA	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 LRP5 NOTCH3	4.91e-10	99	152	11	PS01187
Domain	LDLR_class-A_CS	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5 C6	9.86e-10	40	152	8	IPR023415
Domain	EGF_CA	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 NOTCH3	1.97e-09	86	152	10	PF07645
Domain	TSP_1	ADAMTSL1 ADGRB1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 C6 ADAMTSL2	2.01e-09	63	152	9	PF00090
Domain	Ldl_recept_a	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5 C6	2.67e-09	45	152	8	PF00057
Domain	TSP1	ADAMTSL1 ADGRB1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 C6 ADAMTSL2	2.68e-09	65	152	9	SM00209
Domain	TSP1_rpt	ADAMTSL1 ADGRB1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 C6 ADAMTSL2	2.68e-09	65	152	9	IPR000884
Domain	TSP1	ADAMTSL1 ADGRB1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 C6 ADAMTSL2	2.68e-09	65	152	9	PS50092
Domain	Znf_PHD	KMT2B ING1 PHF24 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6 KDM4B	3.46e-09	91	152	10	IPR001965
Domain	LDLRA_1	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5 C6	4.58e-09	48	152	8	PS01209
Domain	ZF_PHD_2	KMT2B ING1 PHF24 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6 KDM4B	5.29e-09	95	152	10	PS50016
Domain	LDrepeatLR_classA_rpt	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5 C6	5.44e-09	49	152	8	IPR002172
Domain	LDLa	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5 C6	5.44e-09	49	152	8	SM00192
Domain	LDLRA_2	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5 C6	5.44e-09	49	152	8	PS50068
Domain	EGF-like_Ca-bd_dom	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 LRP5 NOTCH3	5.54e-09	124	152	11	IPR001881
Domain	Growth_fac_rcpt_	PCSK5 LAMB1 ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 NOTCH3	5.60e-09	156	152	12	IPR009030
Domain	ZF_PHD_1	KMT2B ING1 PHF24 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6 KDM4B	5.87e-09	96	152	10	PS01359
Domain	EGF_Ca-bd_CS	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 NOTCH3	6.49e-09	97	152	10	IPR018097
Domain	VWC_out	VWF SSPOP JAG2 FCGBP JAG1 MUC2	6.54e-09	19	152	6	SM00215
Domain	ASX_HYDROXYL	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 NOTCH3	8.76e-09	100	152	10	PS00010
Domain	PHD	KMT2B ING1 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6 KDM4B	9.81e-09	75	152	9	PF00628
Domain	EGF-type_Asp/Asn_hydroxyl_site	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 NOTCH3	1.55e-08	106	152	10	IPR000152
Domain	PHD	KMT2B ING1 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6 KDM4B	4.51e-08	89	152	9	SM00249
Domain	EGF_CA	ADGRE2 LDLR LRP8 JAG2 FBN2 HMCN2 MEGF8 JAG1 LRP1 NOTCH3	5.98e-08	122	152	10	SM00179
Domain	Ldl_recept_b	LDLR LRP8 LRP1 LRP6 LRP5	6.31e-08	14	152	5	PF00058
Domain	LDLRB	LDLR LRP8 LRP1 LRP6 LRP5	6.31e-08	14	152	5	PS51120
Domain	-	SSPOP MAMDC4 LDLR LRP8 LRP1 LRP6 LRP5	8.44e-08	46	152	7	4.10.400.10
Domain	LY	LDLR LRP8 LRP1 LRP6 LRP5	9.40e-08	15	152	5	SM00135
Domain	LDLR_classB_rpt	LDLR LRP8 LRP1 LRP6 LRP5	9.40e-08	15	152	5	IPR000033
Domain	Znf_PHD-finger	KMT2B ING1 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6	2.56e-07	79	152	8	IPR019787
Domain	Znf_FYVE_PHD	KMT2B ING1 PHF24 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6 KDM4B	3.47e-07	147	152	10	IPR011011
Domain	VWC	VWF SSPOP JAG2 FCGBP JAG1 MUC2	5.86e-07	38	152	6	SM00214
Domain	-	LDLR LRP8 TENM1 LRP1 LRP6 LRP5	6.88e-07	39	152	6	2.120.10.30
Domain	zf-RanBP	RNF31 TEX13A RYBP NEIL3 CAPN15	7.87e-07	22	152	5	PF00641
Domain	-	KMT2B MARCHF10 ING1 PHF24 ZMYND8 CBLC RNF183 MLLT10 RNF187 TRIM33 RNF123 BAZ2A MARCHF5 UHRF1 MLLT6 KDM4B	8.19e-07	449	152	16	3.30.40.10
Domain	ZnF_RBZ	RNF31 TEX13A RYBP NEIL3 CAPN15	9.99e-07	23	152	5	SM00547
Domain	ZF_RANBP2_2	RNF31 TEX13A RYBP NEIL3 CAPN15	9.99e-07	23	152	5	PS50199
Domain	VWF_dom	VWF SSPOP JAG2 FCGBP JAG1 MUC2	1.08e-06	42	152	6	IPR001007
Domain	Znf_RING/FYVE/PHD	KMT2B MARCHF10 ING1 PHF24 ZMYND8 CBLC RNF183 MLLT10 RNF187 TRIM33 RNF123 BAZ2A MARCHF5 UHRF1 MLLT6 KDM4B	1.09e-06	459	152	16	IPR013083
Domain	ZF_RANBP2_1	RNF31 TEX13A RYBP NEIL3 CAPN15	1.25e-06	24	152	5	PS01358
Domain	Znf_RanBP2	RNF31 TEX13A RYBP NEIL3 CAPN15	1.56e-06	25	152	5	IPR001876
Domain	6-blade_b-propeller_TolB-like	LDLR LRP8 TENM1 LRP1 LRP6 LRP5	1.88e-06	46	152	6	IPR011042
Domain	C8	VWF SSPOP FCGBP MUC2	1.98e-06	12	152	4	PF08742
Domain	TIL	VWF SSPOP FCGBP MUC2	1.98e-06	12	152	4	PF01826
Domain	Unchr_dom_Cys-rich	VWF SSPOP FCGBP MUC2	2.85e-06	13	152	4	IPR014853
Domain	C8	VWF SSPOP FCGBP MUC2	2.85e-06	13	152	4	SM00832
Domain	TIL_dom	VWF SSPOP FCGBP MUC2	3.96e-06	14	152	4	IPR002919
Domain	PLAC	PCSK5 ADAMTSL1 ADAMTS18 ADAMTSL2	3.96e-06	14	152	4	PF08686
Domain	VWF_type-D	VWF SSPOP FCGBP MUC2	7.11e-06	16	152	4	IPR001846
Domain	VWFD	VWF SSPOP FCGBP MUC2	7.11e-06	16	152	4	PS51233
Domain	VWD	VWF SSPOP FCGBP MUC2	7.11e-06	16	152	4	SM00216
Domain	VWD	VWF SSPOP FCGBP MUC2	7.11e-06	16	152	4	PF00094
Domain	Zinc_finger_PHD-type_CS	ING1 PHF24 ZMYND8 MLLT10 TRIM33 MLLT6	1.46e-05	65	152	6	IPR019786
Domain	PLAC	PCSK5 ADAMTSL1 ADAMTS18 ADAMTSL2	1.49e-05	19	152	4	PS50900
Domain	PLAC	PCSK5 ADAMTSL1 ADAMTS18 ADAMTSL2	1.49e-05	19	152	4	IPR010909
Domain	EPHD	KMT2B MLLT10 MLLT6 KDM4B	2.75e-05	22	152	4	PS51805
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL1 ADAMTS18 ADAMTS20 ADAMTSL2	3.95e-05	24	152	4	IPR013273
Domain	Astrotactin	ASTN1 ASTN2	6.58e-05	2	152	2	IPR026995
Domain	LRP5/6	LRP6 LRP5	6.58e-05	2	152	2	IPR017049
Domain	Jagged/Serrate	JAG2 JAG1	6.58e-05	2	152	2	IPR026219
Domain	hEGF	JAG2 FBN2 JAG1 NOTCH3	7.41e-05	28	152	4	PF12661
Domain	EGF	LRP8 JAG2 JAG1 LRP1 LRP6 LRP5 NOTCH3	7.74e-05	126	152	7	PF00008
Domain	MACPF	ASTN1 ASTN2 C6	1.10e-04	12	152	3	IPR020864
Domain	MACPF	ASTN1 ASTN2 C6	1.10e-04	12	152	3	SM00457
Domain	Plexin_repeat	SEMA4F MEGF8 SEMA5B PLXNA1	1.27e-04	32	152	4	IPR002165
Domain	PSI	SEMA4F MEGF8 SEMA5B PLXNA1	1.27e-04	32	152	4	PF01437
Domain	Ig_I-set	ADAMTSL1 TRIO NTRK3 OBSCN HMCN2 CD22 WFIKKN1 MYBPC3	1.67e-04	190	152	8	IPR013098
Domain	I-set	ADAMTSL1 TRIO NTRK3 OBSCN HMCN2 CD22 WFIKKN1 MYBPC3	1.67e-04	190	152	8	PF07679
Domain	VWFC_1	VWF SSPOP JAG2 MUC2	2.03e-04	36	152	4	PS01208
Domain	Ig-like_fold	ADAMTSL1 COL12A1 TRIO COL20A1 NTRK3 OBSCN TGM1 HMCN2 CD22 WFIKKN1 IGHM PKHD1 ASTN1 ASTN2 PLXNA1 MYBPC3	2.11e-04	706	152	16	IPR013783
Domain	VWFC_2	VWF SSPOP JAG2 MUC2	2.51e-04	38	152	4	PS50184
Domain	DSL	JAG2 JAG1	3.91e-04	4	152	2	PF01414
Domain	DSL	JAG2 JAG1	3.91e-04	4	152	2	SM00051
Domain	CTCK_1	VWF SSPOP MUC2	3.94e-04	18	152	3	PS01185
Domain	PSI	SEMA4F MEGF8 SEMA5B PLXNA1	4.44e-04	44	152	4	IPR016201
Domain	PSI	SEMA4F MEGF8 SEMA5B PLXNA1	5.27e-04	46	152	4	SM00423
Domain	VWA	COL12A1 VWF COL20A1 VWA7 HMCN2	6.15e-04	84	152	5	SM00327
Domain	DSL	JAG2 JAG1	6.47e-04	5	152	2	PS51051
Domain	Notch_ligand_N	JAG2 JAG1	6.47e-04	5	152	2	IPR011651
Domain	MNNL	JAG2 JAG1	6.47e-04	5	152	2	PF07657
Domain	DSL	JAG2 JAG1	6.47e-04	5	152	2	IPR001774
Domain	ADAM_spacer1	ADAMTS18 ADAMTS20 ADAMTSL2	8.30e-04	23	152	3	IPR010294
Domain	ADAM_spacer1	ADAMTS18 ADAMTS20 ADAMTSL2	8.30e-04	23	152	3	PF05986
Domain	-	ADAMTSL1 COL12A1 TRIO COL20A1 NTRK3 OBSCN TGM1 CD22 WFIKKN1 PKHD1 ASTN1 ASTN2 PLXNA1 MYBPC3	1.05e-03	663	152	14	2.60.40.10
Domain	Cys_knot_C	VWF SSPOP MUC2	1.07e-03	25	152	3	IPR006207
Domain	CTCK_2	VWF SSPOP MUC2	1.07e-03	25	152	3	PS01225
Domain	VWF_A	COL12A1 VWF COL20A1 VWA7 HMCN2	1.29e-03	99	152	5	IPR002035
Domain	Znf_RING	MARCHF10 RNF31 CBLC RNF183 RNF187 TRIM33 RNF123 MARCHF5 UHRF1	1.43e-03	326	152	9	IPR001841
Domain	EGF_extracell	JAG2 JAG1 TENM1 NOTCH3	1.44e-03	60	152	4	IPR013111
Domain	EGF_2	JAG2 JAG1 TENM1 NOTCH3	1.44e-03	60	152	4	PF07974
Domain	EGF_LAM_2	LAMB1 MEGF8 NTN5	1.83e-03	30	152	3	PS50027
Domain	EGF_LAM_1	LAMB1 MEGF8 NTN5	1.83e-03	30	152	3	PS01248
Domain	Semap_dom	SEMA4F SEMA5B PLXNA1	2.01e-03	31	152	3	IPR001627
Domain	SEMA	SEMA4F SEMA5B PLXNA1	2.01e-03	31	152	3	PS51004
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 ADAMTSL2	2.33e-08	39	114	7	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 ADAMTSL2	2.33e-08	39	114	7	MM15165
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTSL1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 NOTCH3 ADAMTSL2	7.05e-08	68	114	8	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTSL1 THSD7B SSPOP SEMA5B CHST4 ADAMTS18 ADAMTS20 MUC2 ADAMTSL2	2.33e-07	109	114	9	MM15164
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTSL1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 RFT1 NOTCH3 ADAMTSL2	2.32e-06	143	114	9	M27275
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTSL1 THSD7B SSPOP SEMA5B CHST4 ADAMTS18 ADAMTS20 ADAMTSL2	3.16e-06	111	114	8	M27416
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	JAG2 JAG1 NOTCH3	1.39e-04	13	114	3	M47423
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTSL1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 RFT1 NOTCH3 ADAMTSL2	1.93e-04	250	114	9	M27554
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTSL1 ADGRB1 THSD7B SSPOP SEMA5B ADAMTS18 ADAMTS20 C6 ADAMTSL2	5.36e-11	75	155	9	20637190
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ZXDC KMT2B OBSCN TINAGL1 RNF123 CD22 MRC2 JAG1 LRP1 LRP5 NOTCH3	3.69e-09	214	155	11	22199357
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 ZXDC PCSK5 SEMA4F KMT2B TRIO CDK12 TSNARE1 OBSCN CBLC BTAF1 MLLT10 ATP13A2 LDLR TINAGL1 JAG2 ARAP3 MROH1 MEGF8 LRP5 MLLT6 PLXNA1	4.68e-09	1105	155	22	35748872
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LDLR LRP8 LRP1 LRP6 LRP5	3.17e-08	21	155	5	21337463
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CFH NEMP1 COL12A1 ATR ERO1A LAMB1 ADGRE2 LDLR LRP8 JAG2 FBN2 P2RX5 MEGF8 MRC2 LRP1 UHRF1 LRP6 LRP5 RFT1 PLXNA1 NOTCH3	9.79e-08	1201	155	21	35696571
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMB1 FBN2 JAG1 ADAMTS18 NOTCH3	1.01e-07	26	155	5	34189436
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	JAG2 MUC2 NOTCH3	3.46e-07	4	155	3	22691042
Pubmed	Activation of Notch signaling in human tongue carcinoma.	JAG2 JAG1 NOTCH3	3.46e-07	4	155	3	20819128
Pubmed	Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.	JAG2 JAG1 NOTCH3	3.46e-07	4	155	3	20040020
Pubmed	Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.	CFH ADGRE2 CD14 LRP1	3.67e-07	14	155	4	19299737
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LDLR LRP8 LRP1 LRP6	3.67e-07	14	155	4	17389516
Pubmed	Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.	JAG2 JAG1 NOTCH3	8.63e-07	5	155	3	11006133
Pubmed	Functional diversity of notch family genes in fetal lung development.	JAG2 JAG1 NOTCH3	8.63e-07	5	155	3	15064243
Pubmed	Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.	JAG2 JAG1 NOTCH3	8.63e-07	5	155	3	21602525
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	PCSK5 VWF RNF31 LAMB1 JAG2 MEGF8 LRP1	1.06e-06	118	155	7	21078624
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	STAT6 JAG2 JAG1 MUC2 NOTCH3	1.08e-06	41	155	5	22675208
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	ADAMTSL1 COL12A1 VWF LAMB1 SSPOP TINAGL1 FBN2 HMCN2	1.28e-06	175	155	8	28071719
Pubmed	PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.	PCSK5 LDLR LRP8	1.72e-06	6	155	3	20453200
Pubmed	Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.	NKX3-2 JAG2 JAG1 NOTCH3	2.61e-06	22	155	4	21750033
Pubmed	Functional proteomics mapping of a human signaling pathway.	VWF KMT2B CDK12 ZMYND8 XAB2 EPN2 TINAGL1 PIGQ RNF123 FBN2 ZNF451 LRP1 LRP5	2.73e-06	591	155	13	15231748
Pubmed	Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.	JAG2 JAG1 NOTCH3	3.00e-06	7	155	3	10383933
Pubmed	Human ligands of the Notch receptor.	JAG2 JAG1 NOTCH3	3.00e-06	7	155	3	10079256
Pubmed	The distribution of Notch receptors and their ligands during articular cartilage development.	JAG2 JAG1 NOTCH3	3.00e-06	7	155	3	12846471
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LDLR LRP8 LRP1	3.00e-06	7	155	3	12169628
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	NTRK3 LRP8 CDH24 TENM1 ASTN2 PLXNA1	3.47e-06	91	155	6	28558017
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	ERO1A LAMB1 LDLR PLXNA1	4.46e-06	25	155	4	17170699
Pubmed	P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.	JAG2 JAG1 NOTCH3	4.78e-06	8	155	3	22652674
Pubmed	Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.	LDLR LRP8 LRP1	4.78e-06	8	155	3	10380922
Pubmed	Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.	JAG2 JAG1 NOTCH3	4.78e-06	8	155	3	9858718
Pubmed	Notch/Delta expression in the developing mouse lung.	JAG2 JAG1 NOTCH3	4.78e-06	8	155	3	11044610
Pubmed	DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.	APOBEC1 JAG2 JAG1	4.78e-06	8	155	3	17626181
Pubmed	The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.	ZFP42 JAG2 JAG1 LRP6 LRP5 NOTCH3	6.00e-06	100	155	6	24859004
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	VWF FBN2 JAG1	7.15e-06	9	155	3	12122015
Pubmed	Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.	JAG2 JAG1 NOTCH3	7.15e-06	9	155	3	11118901
Pubmed	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.	JAG2 JAG1 NOTCH3	7.15e-06	9	155	3	16245338
Pubmed	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.	LDLR LRP8 LRP1	7.15e-06	9	155	3	20005821
Pubmed	Notch signaling regulates ovarian follicle formation and coordinates follicular growth.	JAG2 POMZP3 JAG1 NOTCH3	9.50e-06	30	155	4	24552588
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	COL20A1 LAMB1 SSPOP TINAGL1 ADAMTS20	1.02e-05	64	155	5	22261194
Pubmed	Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.	JAG2 JAG1 NOTCH3	1.02e-05	10	155	3	23665443
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAMTSL1 COL12A1 VWF LAMB1 TINAGL1 HMCN2 MUC2	1.06e-05	167	155	7	22159717
Pubmed	Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.	AGO2 APOBEC1 LRP6	1.40e-05	11	155	3	28978771
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP6 LRP5	1.40e-05	11	155	3	24639464
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	OTOGL STRC STRCP1	1.40e-05	11	155	3	31776257
Pubmed	Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.	JAG2 JAG1 NOTCH3	1.40e-05	11	155	3	10878608
Pubmed	Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.	JAG2 JAG1 NOTCH3	1.40e-05	11	155	3	12866128
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MIER2 ZXDC ING1 ZMYND8 MLLT10 ZNF334 ATXN1 BAZ2A ZNF451 UHRF1 MLLT6 PLXNA1 KDM4B ZNF513	1.69e-05	808	155	14	20412781
Pubmed	Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.	ITGA4 JAG2 JAG1 NOTCH3	1.78e-05	35	155	4	21252157
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	JAG2 JAG1 NOTCH3	1.85e-05	12	155	3	15465494
Pubmed	Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.	MRC1 MRC2	1.97e-05	2	155	2	19224860
Pubmed	Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion.	JAG1 NOTCH3	1.97e-05	2	155	2	18632624
Pubmed	The interaction between factor H and Von Willebrand factor.	CFH VWF	1.97e-05	2	155	2	23991205
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	1.97e-05	2	155	2	21887268
Pubmed	Low density lipoprotein receptor-related protein polymorphisms are not risk factors for venous thromboembolism.	LDLR LRP1	1.97e-05	2	155	2	17889283
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	1.97e-05	2	155	2	33136328
Pubmed	Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase.	ASTN1 ASTN2	1.97e-05	2	155	2	30696770
Pubmed	Mannose receptor regulation of macrophage cell migration.	MRC1 MRC2	1.97e-05	2	155	2	17596337
Pubmed	Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.	LRP8 LRP1	1.97e-05	2	155	2	12871934
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	1.97e-05	2	155	2	15084453
Pubmed	Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor.	APOBEC1 LDLR	1.97e-05	2	155	2	15145984
Pubmed	The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men.	LDLR LRP5	1.97e-05	2	155	2	17223614
Pubmed	Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.	LDLR LRP1	1.97e-05	2	155	2	11971949
Pubmed	Association of human mannose receptor in sexual transmission of human immunodeficiency virus in serodiscordant couples.	MRC1 MRC2	1.97e-05	2	155	2	23148569
Pubmed	CD22 associates with the human surface IgM-B-cell antigen receptor complex.	CD22 IGHM	1.97e-05	2	155	2	8475064
Pubmed	NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.	JAG1 NOTCH3	1.97e-05	2	155	2	19150886
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	1.97e-05	2	155	2	33164872
Pubmed	CD14 is a ligand for the integrin alpha4beta1.	ITGA4 CD14	1.97e-05	2	155	2	17274987
Pubmed	Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.	OBSCN MYBPC3	1.97e-05	2	155	2	19403693
Pubmed	CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor.	MRC1 MRC2	1.97e-05	2	155	2	15047828
Pubmed	STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children.	STAT6 LRP1	1.97e-05	2	155	2	22534531
Pubmed	LRP: role in vascular wall integrity and protection from atherosclerosis.	LDLR LRP1	1.97e-05	2	155	2	12690199
Pubmed	Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of disease.	APOBEC1 LDLR	1.97e-05	2	155	2	19834105
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	1.97e-05	2	155	2	25902418
Pubmed	Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.	JAG1 NOTCH3	1.97e-05	2	155	2	14714274
Pubmed	Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin.	VWF ITGA4	1.97e-05	2	155	2	9079671
Pubmed	A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.	APOBEC1 LDLR	1.97e-05	2	155	2	9701246
Pubmed	Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.	JAG2 JAG1	1.97e-05	2	155	2	28111308
Pubmed	The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.	FCGBP MUC2	1.97e-05	2	155	2	34126068
Pubmed	Jagged1/Notch3 Signaling Modulates Hemangioma-Derived Pericyte Proliferation and Maturation.	JAG1 NOTCH3	1.97e-05	2	155	2	27941324
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.97e-05	2	155	2	34910522
Pubmed	ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage.	APOBEC1 LDLR	1.97e-05	2	155	2	21829488
Pubmed	CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.	LDLR CROT	1.97e-05	2	155	2	33356393
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	1.97e-05	2	155	2	30474181
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	1.97e-05	2	155	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	1.97e-05	2	155	2	25783012
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	1.97e-05	2	155	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	1.97e-05	2	155	2	15537447
Pubmed	Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.	MRC1 MRC2	1.97e-05	2	155	2	17360361
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	1.97e-05	2	155	2	17335347
Pubmed	Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction.	JAG2 JAG1	1.97e-05	2	155	2	11549580
Pubmed	CD22 is required for protection against West Nile virus Infection.	CD22 IGHM	1.97e-05	2	155	2	23302871
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	1.97e-05	2	155	2	19503830
Pubmed	Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.	LDLR LRP1	1.97e-05	2	155	2	9449704
Pubmed	The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.	LDLR LRP6	1.97e-05	2	155	2	24506864
Pubmed	Normal production rate of apolipoprotein B in LDL receptor-deficient mice.	APOBEC1 LDLR	1.97e-05	2	155	2	12067909
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	1.97e-05	2	155	2	37202775
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	1.97e-05	2	155	2	20926594
Pubmed	The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status.	CFH VWF	1.97e-05	2	155	2	24014239
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	1.97e-05	2	155	2	16355283
Pubmed	Prognostic Subcellular Notch2, Notch3 and Jagged1 Localization Patterns in Early Triple-negative Breast Cancer.	JAG1 NOTCH3	1.97e-05	2	155	2	28476798
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	1.97e-05	2	155	2	28425175
Interaction	NTN5 interactions	LDLR JAG2 FBN2 NTN5 NOTCH3	8.94e-07	24	153	5	int:NTN5
Interaction	IGFL3 interactions	PCSK5 LAMB1 LDLR JAG2 FBN2 LRP5 NOTCH3	1.63e-06	75	153	7	int:IGFL3
Interaction	MFAP5 interactions	VWF LDLR JAG2 FBN2 JAG1 NOTCH3	2.65e-06	52	153	6	int:MFAP5
Interaction	FBXO2 interactions	PCSK5 COL12A1 LAMB1 ITGA4 TINAGL1 JAG2 FBN2 CD14 MEGF8 MRC2 IGHM JAG1 PLXNA1 NOTCH3	3.16e-06	411	153	14	int:FBXO2
Interaction	HLA-G interactions	JAG2 RNF123 MEGF8 MRC2 LRP6 LRP5 TBL2 PLXNA1	3.32e-06	118	153	8	int:HLA-G
Interaction	LYPD1 interactions	PCSK5 LAMB1 JAG2 MEGF8 LRP6 LRP5	5.07e-06	58	153	6	int:LYPD1
Interaction	ATXN7 interactions	VWF RNF31 LAMB1 PALB2 JAG2 RYBP MEGF8	1.98e-05	109	153	7	int:ATXN7
Interaction	PI15 interactions	PCSK5 LDLR TINAGL1 LRP6 LRP5 PLXNA1	4.05e-05	83	153	6	int:PI15
Cytoband	15q15.3	ZSCAN29 STRC STRCP1	8.22e-05	25	155	3	15q15.3
Cytoband	8q24.3	TSNARE1 ADGRB1 ZNF707 MROH1	6.05e-04	113	155	4	8q24.3
Cytoband	12q13.3	NEMP1 BAZ2A LRP1	6.98e-04	51	155	3	12q13.3
Cytoband	19q13.1	KMT2B FCGBP CD22	8.71e-04	55	155	3	19q13.1
GeneFamily	PHD finger proteins	KMT2B ING1 PHF24 ZMYND8 MLLT10 TRIM33 BAZ2A UHRF1 MLLT6	5.27e-09	90	114	9	88
GeneFamily	Low density lipoprotein receptors	LDLR LRP8 LRP1 LRP6 LRP5	1.13e-08	13	114	5	634
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RNF31 TEX13A RYBP NEIL3 CAPN15	1.71e-07	21	114	5	89
GeneFamily	Ring finger proteins	MARCHF10 RNF31 CBLC RNF183 RNF187 TRIM33 RNF123 MARCHF5 UHRF1	6.16e-05	275	114	9	58
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 TRIO NTRK3 OBSCN HMCN2 WFIKKN1 MYBPC3	7.22e-05	161	114	7	593
GeneFamily	Fibronectin type III domain containing	COL12A1 COL20A1 OBSCN ASTN1 ASTN2 MYBPC3	5.31e-04	160	114	6	555
GeneFamily	ADAMTS like	ADAMTSL1 ADAMTSL2	8.11e-04	7	114	2	947
GeneFamily	Ring finger proteins\|Membrane associated ring-CH-type fingers	MARCHF10 MARCHF5	2.09e-03	11	114	2	60
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC1 APOBEC3F	2.50e-03	12	114	2	406
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MRC1 ITGA4 ADGRE2 CD14 CD22 MRC2 JAG1 LRP1	3.50e-03	394	114	8	471
GeneFamily	Dyneins, axonemal	DNAH6 DNAH9	5.04e-03	17	114	2	536
GeneFamily	EF-hand domain containing\|Nucleotide excision repair\|Transcription and export complex 2	DDB2 XAB2	5.64e-03	18	114	2	1269
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS18 ADAMTS20	6.28e-03	19	114	2	50
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA4F SEMA5B	6.95e-03	20	114	2	736
Coexpression	NABA_MATRISOME	PCSK5 SEMA4F ADAMTSL1 COL12A1 VWF COL20A1 LAMB1 VWA7 SSPOP TINAGL1 TGM1 POMZP3 FBN2 HMCN2 MEGF8 SEMA5B OTOGL WFIKKN1 NTN5 ADAMTS18 ADAMTS20 MUC2 PLXNA1 ADAMTSL2	5.50e-09	1008	154	24	MM17056
Coexpression	NABA_MATRISOME	PCSK5 SEMA4F ADAMTSL1 COL12A1 VWF COL20A1 LAMB1 VWA7 SSPOP TINAGL1 TGM1 POMZP3 FBN2 HMCN2 MEGF8 SEMA5B WFIKKN1 NTN5 ADAMTS18 ADAMTS20 MUC2 PLXNA1 ADAMTSL2	3.59e-08	1026	154	23	M5889
Coexpression	NABA_CORE_MATRISOME	COL12A1 VWF COL20A1 LAMB1 VWA7 SSPOP TINAGL1 POMZP3 FBN2 HMCN2 OTOGL NTN5	7.32e-08	270	154	12	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	VWF LAMB1 VWA7 SSPOP TINAGL1 POMZP3 FBN2 HMCN2 OTOGL NTN5	2.06e-07	191	154	10	MM17059
Coexpression	NABA_CORE_MATRISOME	COL12A1 VWF COL20A1 LAMB1 VWA7 SSPOP TINAGL1 POMZP3 FBN2 HMCN2 NTN5	7.42e-07	275	154	11	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	VWF LAMB1 VWA7 SSPOP TINAGL1 POMZP3 FBN2 HMCN2 NTN5	2.53e-06	196	154	9	M3008
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_VASCULAR_SMC_1_CELL	NTRK3 ITGA4 BTBD3 TINAGL1 SEMA5B JAG1 NOTCH3	8.93e-06	124	154	7	M45686
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HPERIC	CFH LAYN PGGHG ING1 NKX3-2 LAMB1 ITGA4 ZIC1 STAT6 PPARGC1B ARAP3 MRC2 JAG1 LRP1 ADAMTS18 NOTCH3	1.92e-05	795	154	16	M39050
Coexpression	HOEBEKE_LYMPHOID_STEM_CELL_UP	ATR PGGHG ITGA4 ADGRE2 TRIM33 IGHM	2.37e-05	97	154	6	M14698
Coexpression	GSE17721_0.5H_VS_24H_POLYIC_BMDC_DN	MED20 LAMB1 TUT1 MLLT10 ITGA4 CD14 BAZ2A FBXW11	2.43e-05	199	154	8	M4097
CoexpressionAtlas	kidney_adult_Mesangium_Meis_k-means-cluster#4_top-relative-expression-ranked_500	CFH COL12A1 XDH CD14 LRP1	9.77e-06	40	153	5	gudmap_kidney_adult_Mesangium_Meis_k4_500
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 OBSCN SSPOP FBN2 OTOGL PKHD1 TENM1 ADAMTS20 DNAH9	1.77e-08	184	155	9	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 OBSCN SSPOP FBN2 OTOGL PKHD1 TENM1 ADAMTS20 DNAH9	1.77e-08	184	155	9	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 OBSCN SSPOP FBN2 OTOGL PKHD1 TENM1 ADAMTS20 DNAH9	1.77e-08	184	155	9	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK3 COL12A1 ITGA4 TINAGL1 SEMA5B JAG1 LGR6 NOTCH3 ADAMTSL2	2.67e-08	193	155	9	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	COL12A1 NTRK3 ADGRB1 EXTL1 THSD7B TINAGL1 ADAMTS18 LGR6	9.03e-08	159	155	8	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH ADAMTSL1 COL12A1 EXTL1 LRP8 CDH24 TENM1 LGR6	2.34e-07	180	155	8	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NTRK3 LAMB1 ITGA4 BTBD3 TINAGL1 SEMA5B JAG1 NOTCH3	3.13e-07	187	155	8	1aebf6fab40b96f2f5feb77a302bb805838fccf3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NTRK3 ADGRB1 LAMB1 ITGA4 SEMA5B OTOGL ADAMTS18 NOTCH3	3.53e-07	190	155	8	10125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL12A1 NTRK3 ADGRB1 ITGA4 TINAGL1 SEMA5B ASTN1 NOTCH3	3.83e-07	192	155	8	5000440dc1ed17e7474d340921bdff945646f27e
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL12A1 NTRK3 LAMB1 BTBD3 TINAGL1 SEMA5B JAG1 NOTCH3	3.98e-07	193	155	8	ba6eb29478d16589172f48f9992e5116328c81d6
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 XDH ITGA4 ADGRE2 LDLR ACOT11 JAG1	1.12e-06	153	155	7	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	VWF ZMYND8 CAGE1 P2RX5 CD22 IGHM KDM4B	1.51e-06	160	155	7	bfbac5ed3273b4430314c6c25cdc1bf0c42b27a1
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 COL12A1 CPB1 EXTL1 FCGBP ADAMTS20 GP2	1.57e-06	161	155	7	b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 COL12A1 CPB1 EXTL1 FCGBP ADAMTS20 GP2	1.57e-06	161	155	7	f7a89c481f789f624102857be722c95fbeb47595
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	NTRK3 CDH24 HMCN2 CD22 JAG1 LGR6 NOTCH3	1.57e-06	161	155	7	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK3 NTRK3 OTOGL PKHD1 TENM1 LGR6 DNAH9	1.64e-06	162	155	7	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAS1R3 OTOGL PKHD1 SORCS3 C6 DNAH6 DNAH9	2.17e-06	169	155	7	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 ADAMTSL1 LRP8 CDH24 TENM1 SORCS3 LGR6	2.26e-06	170	155	7	417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	CFH VWF XDH MAMDC4 HMCN2 SCN4A C6	2.35e-06	171	155	7	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	ADAMTSL1 NTRK3 TINAGL1 SEMA5B JAG1 LGR6 NOTCH3	2.44e-06	172	155	7	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL12A1 NTRK3 ITGA4 TINAGL1 SEMA5B JAG1 NOTCH3	2.63e-06	174	155	7	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFH VWF JAG2 FBN2 ARAP3 HMCN2 JAG1	2.84e-06	176	155	7	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH VWF MARCHF10 EXTL1 FBN2 HMCN2 JAG1	3.18e-06	179	155	7	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF TINAGL1 ARAP3 ZNF436 NTN5 NOTCH3 ADAMTSL2	3.30e-06	180	155	7	455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCell	Pericytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTSL1 NTRK3 MYRFL TINAGL1 SEMA5B OTOGL NOTCH3	3.55e-06	182	155	7	46c213597445b1f4f09dc367f27702d24b201daf
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH ADAMTSL1 COL12A1 EXTL1 SEMA5B TENM1 LGR6	3.55e-06	182	155	7	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFH ADAMTSL1 COL12A1 EXTL1 SEMA5B TENM1 LGR6	3.55e-06	182	155	7	05c167158815bf25d509df59ab386e1990712765
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTRK3 ITGA4 BTBD3 FBN2 SEMA5B JAG1 NOTCH3	3.68e-06	183	155	7	4060d979948e1dd7507977629a7fbdfa4ca65bb6
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTRK3 ITGA4 BTBD3 FBN2 SEMA5B JAG1 NOTCH3	3.68e-06	183	155	7	0d44a978221cf3f733704bf11863502805fba733
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PHF24 OTOGL PKHD1 LRP1 ADAMTS20 SORCS3 ASTN1	4.09e-06	186	155	7	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MED20 ZXDC ADAMTSL1 VWF LAMB1 CDH24	4.39e-06	188	155	7	524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell	11.5-Airway-Mesenchymal-Pericyte\|Airway / Age, Tissue, Lineage and Cell class	NTRK3 ADGRB1 ITGA4 TINAGL1 SEMA5B JAG1 NOTCH3	4.39e-06	188	155	7	916971d8660fd20f616346953874e89d2cd13e88
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MED20 ZXDC ADAMTSL1 VWF LAMB1 CDH24	4.39e-06	188	155	7	1b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MED20 ZXDC ADAMTSL1 VWF LAMB1 CDH24	4.39e-06	188	155	7	cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell	15-Distal-Mesenchymal-Pericyte\|Distal / Age, Tissue, Lineage and Cell class	NTRK3 LAMB1 ITGA4 TINAGL1 SEMA5B ASTN1 NOTCH3	4.39e-06	188	155	7	4963382e54aac06bf5047c7d725393db70667ee7
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MED20 ZXDC ADAMTSL1 VWF LAMB1 CDH24	4.39e-06	188	155	7	f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell	5'-Airway_Nasal-Endothelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH MED20 ZXDC ADAMTSL1 VWF LAMB1 CDH24	4.39e-06	188	155	7	6c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NTRK3 LAMB1 ITGA4 SEMA5B JAG1 ADAMTS18 NOTCH3	4.55e-06	189	155	7	9c2492c38f27e4c699b40680652e4c64911cce52
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAMTSL1 COL12A1 NTRK3 HMCN2 MRC2 LRP1	4.71e-06	190	155	7	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTRK3 GFRA4 TINAGL1 SEMA5B JAG1 PLXNA1 NOTCH3	4.71e-06	190	155	7	7df63e5e0dd395676f4fc18cad0d8b2428390943
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTRK3 GFRA4 TINAGL1 SEMA5B JAG1 PLXNA1 NOTCH3	4.71e-06	190	155	7	140aca04c044cd7a93f81ff1631b00b5216d2cb1
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	COL12A1 NTRK3 TINAGL1 SEMA5B JAG1 LGR6 NOTCH3	4.87e-06	191	155	7	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NTRK3 ADGRB1 ITGA4 TINAGL1 SEMA5B ASTN1 NOTCH3	5.04e-06	192	155	7	55f95454399fd533df75db06584eaa48d6ee3830
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CFH PCSK5 COL12A1 VWF LAMB1 MRC2 LRP1	5.04e-06	192	155	7	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-B_cell-B_cell-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SEMA4F ATR LRP8 P2RX5 CD22 IGHM MFSD8	5.40e-06	194	155	7	9a99abc65e7509e7ae8fb392f5ee4b2a83128072
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL12A1 ITGA4 SEMA5B JAG1 LGR6 NOTCH3 ADAMTSL2	5.40e-06	194	155	7	67f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH COL12A1 NTRK3 MRC2 LRP1 NOTCH3 ADAMTSL2	5.58e-06	195	155	7	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTRK3 ITGA4 GFRA4 SEMA5B JAG1 PLXNA1 NOTCH3	5.58e-06	195	155	7	43d372373367b71243c6ea958aedccde4478618f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFH COL12A1 LAMB1 ZIC1 TINAGL1 JAG1 NOTCH3	5.58e-06	195	155	7	d760d1423f9a8a373fe7b250ea9b1d67a0c0059f
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NTRK3 LAMB1 BTBD3 TINAGL1 SEMA5B JAG1 NOTCH3	5.77e-06	196	155	7	40cae477b3906623d1f2a4c630279e710499ce80
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH COL12A1 TRIO NTRK3 FBN2 SEMA5B MRC2	5.77e-06	196	155	7	eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH PCSK5 VWF JAG2 CDH24 ARAP3 JAG1	6.17e-06	198	155	7	5e781583908c4ee107d986904a646a7c6b8e3591
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PCSK5 LAYN OBSCN JAG2 CROT JAG1 LGR6	6.17e-06	198	155	7	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 NTRK3 EXTL1 LDLR LRP1 LRP6 ASTN1	6.37e-06	199	155	7	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH ADAMTSL1 COL12A1 LAMB1 MRC2 TENM1 LRP1	6.59e-06	200	155	7	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	LAMB1 FBN2 OTOGL MRC2 LRP1 LRP6 NOTCH3	6.59e-06	200	155	7	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH NTRK3 LAMB1 MRC2 TENM1 LRP1 ADAMTSL2	6.59e-06	200	155	7	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	ASK454-Epithelial-Type_2\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	AGO2 APOBEC3F TGM1 MEGF8 ACOT11 PLXNA1	8.24e-06	136	155	6	ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	NEMP1 OBSCN LAMB1 TENM1 SORCS3	8.88e-06	80	155	5	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CASR MYRFL CHST4 TXNDC2 GP2	1.58e-05	90	155	5	78d902ca4490bd9cf6b3c8c239dd91c500c28f42
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CASR MYRFL CHST4 TXNDC2 GP2	1.58e-05	90	155	5	45a54b29d2696c50a3dc3a4b6dd00664c7052be8
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 XDH ITGA4 ADGRE2 LDLR JAG1	1.80e-05	156	155	6	2ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTRK3 ADGRB1 LAMB1 ITGA4 LRP6 NOTCH3	1.87e-05	157	155	6	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEMP1 ADAMTSL1 AGO2 ATR CBLC JAG2	1.87e-05	157	155	6	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL12A1 NTRK3 SEMA5B JAG1 LGR6 NOTCH3	1.93e-05	158	155	6	8d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	ADAMTSL1 NTRK3 TINAGL1 SEMA5B JAG1 NOTCH3	2.08e-05	160	155	6	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	NTRK3 CDH24 CD22 JAG1 LGR6 NOTCH3	2.08e-05	160	155	6	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NTRK3 TINAGL1 SEMA5B LGR6 STRC NOTCH3	2.31e-05	163	155	6	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGO2 KMT2B AGBL5 MEGF8 ZNF451 ASTN1	2.31e-05	163	155	6	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	droplet-Kidney-KIDNEY-30m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH MRC1 APOBEC1 CD14 LRP1 C6	2.39e-05	164	155	6	eba25e4d65ca66b5192a7a4d11423f3fa0956828
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 ADAMTSL1 MARCHF10 CFAP65 PKHD1 DNAH6	2.47e-05	165	155	6	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 ADAMTSL1 MARCHF10 CFAP65 PKHD1 DNAH6	2.47e-05	165	155	6	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CFH THSD7B FCGBP PLPP2 CHST4 NOTCH3	2.64e-05	167	155	6	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	TCGA-Pancreas\|World / Sample_Type by Project: Shred V9	CASR CPB1 APOBEC1 CHST4 C6 GP2	2.73e-05	168	155	6	279d5fcf9bd3f56ab560e37eed6fb3bd57dd93de
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 ADAMTSL1 THSD7B CDH24 TENM1 LGR6	2.83e-05	169	155	6	1c9e54e7b14eb99996590fb93b257cf881a9f184
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRE2 ATP13A2 CD14 LRP1 C6 NOTCH3	2.83e-05	169	155	6	0f5e737b265ba333275a0cd289dab029a1542075
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRE2 ATP13A2 CD14 LRP1 C6 NOTCH3	2.83e-05	169	155	6	aec1b4c7e973a31c53aaea47c2c05d24ce16aa4f
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTRK3 ADGRB1 OTOGL LRP1 ADAMTS18 NOTCH3	2.92e-05	170	155	6	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA4 SEMA5B JAG1 SCN4A LGR6 NOTCH3	3.02e-05	171	155	6	285533ca2a6a411773313166bee35542f34d1a3c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRIO LAMB1 XDH PKHD1 SORCS3 ASTN2	3.12e-05	172	155	6	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH ADAMTSL1 COL12A1 TRIO MRC2 LRP1	3.12e-05	172	155	6	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRIO LAMB1 XDH PKHD1 SORCS3 ASTN2	3.12e-05	172	155	6	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOBEC1 ITGA4 ATP13A2 LDLR CD14 LRP1	3.12e-05	172	155	6	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	CFH COL12A1 MARCHF10 NTRK3 NKX3-2 TGM1	3.22e-05	173	155	6	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 ADAMTSL1 LRP8 CDH24 TENM1 SORCS3	3.33e-05	174	155	6	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 TINAGL1 SEMA5B MRC2 LRP1 NOTCH3	3.44e-05	175	155	6	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZXDC MRC1 LDLR RNF123 CD14 IGHM	3.44e-05	175	155	6	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 NTRK3 OTOGL JAG1 LGR6 NOTCH3	3.44e-05	175	155	6	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 NTRK3 OTOGL JAG1 LGR6 NOTCH3	3.44e-05	175	155	6	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ASPHD2 ACOT11 NTN5 UHRF1 RAB11FIP5 SORCS3	3.44e-05	175	155	6	085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-SMG_basal_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	XDH CPB1 PLPP2 SCN4A ADAMTS18 LGR6	3.55e-05	176	155	6	045b12c90f7dd49a9778dadcdf8f18125b380531
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK5 ADAMTSL1 LRP8 SEMA5B TENM1 SORCS3	3.66e-05	177	155	6	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTRK3 ITGA4 SEMA5B JAG1 ADAMTS20 NOTCH3	3.78e-05	178	155	6	9fc5688cf705a74398d24e10e0aab4758612e72b
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NTRK3 THSD7B TINAGL1 SEMA5B JAG1 NOTCH3	3.78e-05	178	155	6	066dbc4cc2083c549d98122ed44707127f34d582
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH ZFP42 CPB1 TGM1 CHST4 ADAMTS20	3.90e-05	179	155	6	056df2aaff750e0e283e7da78fcc3c90c366aac0
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH ZFP42 CPB1 TGM1 CHST4 ADAMTS20	3.90e-05	179	155	6	f5f3945ef3b9efc5921a71fd51deeb2c80f0ce11
ToppCell	facs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 NTRK3 ZNF707 SEMA5B ASTN1 NOTCH3	4.02e-05	180	155	6	0059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCell	facs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 NTRK3 ZNF707 SEMA5B ASTN1 NOTCH3	4.02e-05	180	155	6	dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCell	facs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 TINAGL1 SEMA5B JAG1 ASTN1 NOTCH3	4.15e-05	181	155	6	429df38438d5a7ff490c9ede34b69e2970c7ded2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 TINAGL1 SEMA5B MRC2 LRP1 NOTCH3	4.15e-05	181	155	6	a2058d658f07ab6f0a28d2622f3090b4cde6f763
Drug	fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	ZXDC ZMYND8 NKX3-2 MLLT10 LDLR EPN2 ATXN1 PLXNA1 KDM4B	4.84e-06	186	153	9	6996_UP
Drug	Deferoxamine mesylate [138-14-7]; Down 200; 6uM; MCF7; HT_HG-U133A	TRIO ING1 LAMB1 BTBD3 EPN2 CD22 BAZ2A JAG1 LRP6	7.72e-06	197	153	9	3417_DN
Drug	Amprolium hydrochloride [137-88-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	TRIO ZMYND8 LAMB1 MLLT10 LDLR EPN2 ATXN1 JAG1 KDM4B	8.04e-06	198	153	9	1479_DN
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Down 200; 4.8uM; PC3; HT_HG-U133A	ING1 NTRK3 CPB1 TUT1 MLLT10 TINAGL1 ASTN2 NOTCH3 CAPN15	8.37e-06	199	153	9	4211_DN
Drug	tesmilifene	ITGA4 CD14 LRP1	1.63e-05	8	153	3	ctd:C043062
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	ZXDC KMT2B TUT1 MLLT10 EPN2 TRIM33 P2RX5 NEIL3	3.85e-05	186	153	8	916_DN
Drug	Lycorine hydrochloride [2188-68-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A	SEMA4F ZMYND8 NKX3-2 STAT6 LRP8 JAG2 CROT ASTN2	3.85e-05	186	153	8	6051_DN
Drug	Naproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A	KMT2B ZMYND8 LDLR EPN2 TRIM33 ACOT11 LRP6 ASTN2	4.65e-05	191	153	8	1706_DN
Drug	monastrol; Up 200; 100uM; MCF7; HG-U133A	TRIO ERO1A NKX3-2 TUT1 TINAGL1 ACOT11 LRP6 KDM4B	5.38e-05	195	153	8	311_UP
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	KMT2B PGGHG NKX3-2 TUT1 XAB2 LRP6 PLXNA1 KDM4B	5.58e-05	196	153	8	2437_DN
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	PHF24 ZMYND8 XDH MRC2 ASTN1 ASTN2 KDM4B MYBPC3	5.58e-05	196	153	8	6169_UP
Drug	Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; MCF7; HT_HG-U133A	MIER2 RNF31 TRIO ERO1A ATP13A2 XAB2 EPN2 BAZ2A	5.78e-05	197	153	8	5303_DN
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	CDK12 LAMB1 LDLR CD22 LRP6 PLXNA1 KDM4B CAPN15	5.78e-05	197	153	8	7185_DN
Drug	Imipenem [74431-23-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A	MIER2 CPB1 CD22 BAZ2A JAG1 SCN4A RAB11FIP5 ZNF552	5.78e-05	197	153	8	2873_UP
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; PC3; HT_HG-U133A	SEMA4F TRIO ING1 NKX3-2 XAB2 STAT6 TINAGL1 ASTN2	5.78e-05	197	153	8	4336_DN
Drug	Flufenamic acid [530-78-9]; Up 200; 14.2uM; PC3; HT_HG-U133A	PHF24 XDH MLLT10 XAB2 JAG2 ZNF334 ACOT11 MYBPC3	5.99e-05	198	153	8	5059_UP
Drug	Amikacin hydrate [37517-28-5]; Down 200; 6.6uM; MCF7; HT_HG-U133A	TRIO RNF187 XAB2 EPN2 MRC2 JAG1 LRP6 NEIL3	5.99e-05	198	153	8	5314_DN
Drug	Biotin [58-85-5]; Down 200; 16.4uM; MCF7; HT_HG-U133A	ZMYND8 LAMB1 MLLT10 ATP13A2 JAG1 ZNF552 ASTN2 CAPN15	5.99e-05	198	153	8	3289_DN
Drug	2-nitroisocitrate	DOCK3 COL12A1 AASDHPPT CROT NOTCH3	6.10e-05	62	153	5	CID000166578
Drug	Methiazole; Up 200; 15uM; MCF7; HT_HG-U133A	SHANK1 CPB1 EPN2 TRIM33 FBN2 CD22 ADAMTS20 KDM4B	6.20e-05	199	153	8	3878_UP
Drug	DAPH; Up 200; 10uM; PC3; HG-U133A	KMT2B XDH DDB2 STAT6 TINAGL1 TRIM33 MRC2 ZNF552	6.20e-05	199	153	8	578_UP
Drug	Triprolidine	ITGA4 CD14 LRP1	6.26e-05	12	153	3	ctd:D014311
Disease	Malignant neoplasm of breast	VWF OBSCN XDH MAMDC4 PALB2 JAG2 PPARGC1B ARAP3 SEMA5B OTOGL ZNF436 JAG1 TENM1 ASTN2 LGR6 RASL10B DNAH9 NOTCH3	7.80e-06	1074	148	18	C0006142
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	2.50e-05	2	148	2	DOID:0110471 (implicated_via_orthology)
Disease	health study participation	LAYN TSNARE1 VWA7 DDB2 BTBD3 UHRF1 KDM4B	6.02e-05	195	148	7	EFO_0010130
Disease	low-density lipoprotein receptor-related protein 8 measurement	CFH LRP8	7.47e-05	3	148	2	EFO_0020538
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B TRIO KDM4B	7.99e-05	17	148	3	DOID:0060307 (is_implicated_in)
Disease	sorting nexin-1 measurement	CFH RNF123	1.49e-04	4	148	2	EFO_0803092
Disease	Squamous cell carcinoma of oropharynx	ATR ING1	1.49e-04	4	148	2	C0280313
Disease	semaphorin-6A measurement	CFH MRC1	1.49e-04	4	148	2	EFO_0020721
Disease	adhesion G protein-coupled receptor E2 measurement	CFH ADGRE2	1.49e-04	4	148	2	EFO_0021892
Disease	Carcinoma, Pancreatic Ductal	JAG2 JAG1 NOTCH3	2.32e-04	24	148	3	C0887833
Disease	layilin measurement	CFH LAYN	2.47e-04	5	148	2	EFO_0020529
Disease	adenoid cystic carcinoma (is_implicated_in)	ATR NTRK3	2.47e-04	5	148	2	DOID:0080202 (is_implicated_in)
Disease	adult onset asthma	LAYN VWA7 STAT6 LRP1 MUC2	3.29e-04	118	148	5	EFO_1002011
Disease	smoking behavior, BMI-adjusted waist circumference	DOCK3 PCSK5 ATP13A2 RYBP FBXW11	3.84e-04	122	148	5	EFO_0004318, EFO_0007789
Disease	complement factor H-related protein 2 measurement	CFH COL12A1 MFSD8	4.11e-04	29	148	3	EFO_0600055
Disease	cortical thickness	COL12A1 KMT2B MLLT10 ATP13A2 LRP8 JAG2 FBN2 JAG1 PKHD1 LRP1 ADAMTS18 ADAMTS20 ASTN2 KLHL18 KDM4B	4.95e-04	1113	148	15	EFO_0004840
Disease	Common Migraine	LRP1 ASTN2	5.16e-04	7	148	2	C0338480
Disease	vascular cell adhesion protein 1 measurement	CFH ITGA4	5.16e-04	7	148	2	EFO_0020846
Disease	toll-like receptor 4:Lymphocyte antigen 96 complex measurement	CFH ASTN2	5.16e-04	7	148	2	EFO_0008301
Disease	aspartate aminotransferase measurement	CFH MRC1 OBSCN XDH THSD7B MLLT10 CROT HMCN2 CD14 ATXN1 BAZ2A ASTN2 MYBPC3	6.55e-04	904	148	13	EFO_0004736
Disease	bone density	ADAMTSL1 DDB2 FBN2 ATXN1 JAG1 ADAMTS18 RAB11FIP5 LRP5	7.93e-04	388	148	8	EFO_0003923
Disease	apolipoprotein D measurement	CFH C6	8.79e-04	9	148	2	EFO_0020156
Disease	kallikrein-14 measurement	CFH C6	8.79e-04	9	148	2	EFO_0020513
Disease	Gout	XDH CD14	8.79e-04	9	148	2	C0018099
Disease	migraine disorder, Headache	NEMP1 STAT6 LRP1 ASTN2	9.38e-04	86	148	4	HP_0002315, MONDO_0005277
Disease	thioredoxin domain-containing protein 12 measurement	DOCK3 RNF123 KLHL18	9.90e-04	39	148	3	EFO_0008298
Disease	multiple system atrophy	XDH THSD7B FBN2	1.07e-03	40	148	3	EFO_1001050
Disease	Facies	JAG1 ADAMTSL2	1.10e-03	10	148	2	C0282631
Disease	tropomyosin beta chain measurement	CFH C6	1.10e-03	10	148	2	EFO_0020787
Disease	obstructive jaundice (biomarker_via_orthology)	CFH CD14	1.10e-03	10	148	2	DOID:13603 (biomarker_via_orthology)
Disease	pneumonia (implicated_via_orthology)	ITGA4 MUC2	1.10e-03	10	148	2	DOID:552 (implicated_via_orthology)
Disease	cortical surface area measurement	ADAMTSL1 AGBL5 ATP13A2 ZIC1 LRP8 TINAGL1 JAG2 PIGQ FBN2 JAG1 PKHD1 ADAMTS18 ADAMTS20 UHRF1 ASTN2 RPS6KL1	1.21e-03	1345	148	16	EFO_0010736
Disease	lifestyle measurement	DOCK3 TSNARE1 MLLT10 BTBD3 EPN2 ARAP3	1.23e-03	235	148	6	EFO_0010724
Disease	tumor necrosis factor receptor superfamily member 11B measurement	CFH C6	1.33e-03	11	148	2	EFO_0020801
Disease	multisite chronic pain	MLLT10 RNF123 SORCS3 ASTN2	1.36e-03	95	148	4	EFO_0010100
Disease	body surface area	PCSK5 ATP13A2 ZIC1 RYBP FBN2 SCN4A PKHD1 UHRF1 ASTN2 FBXW11	1.56e-03	643	148	10	EFO_0022196
Disease	familial hyperlipidemia (implicated_via_orthology)	APOBEC1 LDLR	1.60e-03	12	148	2	DOID:1168 (implicated_via_orthology)
Disease	tyrosine-protein kinase ZAP-70 measurement	CFH C6	1.60e-03	12	148	2	EFO_0020833
Disease	Leukemia, Myelocytic, Acute	TRIO NTRK3 CBLC MLLT10 PALB2	1.84e-03	173	148	5	C0023467
Disease	Migraine Disorders	LRP1 NOTCH3	1.88e-03	13	148	2	C0149931
Disease	response to fenofibrate	PCSK5 PPARGC1B C6	2.04e-03	50	148	3	GO_1901557
Disease	Autistic Disorder	SHANK1 LAMB1 XDH ITGA4 RAB11FIP5 ASTN2	2.09e-03	261	148	6	C0004352
Disease	cognitive function measurement, self reported educational attainment	AGO2 TSNARE1 BTAF1 THSD7B PKHD1 RAB11FIP5 SORCS3	2.16e-03	355	148	7	EFO_0004784, EFO_0008354
Disease	revision of total hip arthroplasty	VWA7 STRCP1	2.19e-03	14	148	2	EFO_0020973
Disease	autosomal dominant polycystic kidney disease (is_marker_for)	STAT6 CD14	2.19e-03	14	148	2	DOID:898 (is_marker_for)
Disease	Glioblastoma Multiforme	JAG2 TRIM33 JAG1 NOTCH3	2.40e-03	111	148	4	C1621958
Disease	methylcobalamin deficiency type cblE, brain serotonin transporter measurement	VWF TRIO	2.86e-03	16	148	2	EFO_0004569, MONDO_0009354
Disease	sarcoidosis (is_implicated_in)	CFH CD14	2.86e-03	16	148	2	DOID:11335 (is_implicated_in)
Disease	migraine without aura, susceptibility to, 4	LRP1 ASTN2	2.86e-03	16	148	2	MONDO_0011847
Disease	neuroimaging measurement	MRC1 KMT2B MLLT10 ATP13A2 LRP8 JAG2 FBN2 JAG1 PKHD1 ADAMTS18 ADAMTS20 TBL2 KDM4B	2.90e-03	1069	148	13	EFO_0004346
Disease	Colorectal Carcinoma	SHANK1 OBSCN FBN2 ARAP3 PKHD1 TENM1 LRP1 ADAMTS18 C12orf76 LGR6	2.94e-03	702	148	10	C0009402
Disease	immature platelet measurement	DOCK3 VWF ZMYND8 BAZ2A	3.09e-03	119	148	4	EFO_0803541
Disease	1-Methylhistidine measurement	CDK12 OTOGL	3.23e-03	17	148	2	EFO_0021543
Disease	Van Buchem disease	LRP5 ADAMTSL2	3.23e-03	17	148	2	C0432272
Disease	renal fibrosis (implicated_via_orthology)	XDH STAT6	3.23e-03	17	148	2	DOID:0050855 (implicated_via_orthology)
Disease	Lipidemias	LDLR PPARGC1B	3.23e-03	17	148	2	C1706412
Disease	Hyperlipidemia	LDLR PPARGC1B	3.23e-03	17	148	2	C0020473
Disease	bipolar disorder, sex interaction measurement	TSNARE1 ADGRB1	3.63e-03	18	148	2	EFO_0008343, MONDO_0004985
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	MLLT10 ASTN2	3.63e-03	18	148	2	EFO_1000649, HP_0000131
Disease	parahippocampal gyrus volume measurement	ZMYND8 XDH	3.63e-03	18	148	2	EFO_0010318
Disease	vital capacity	CFH PCSK5 ADAMTSL1 CDK12 MLLT10 ATP13A2 RYBP MRC2 ADAMTS18 UHRF1 LRP6 ASTN2 PLXNA1 KDM4B	3.81e-03	1236	148	14	EFO_0004312
Disease	alcohol consumption measurement	COL12A1 CDK12 ADGRB1 THSD7B ITGA4 BTBD3 ZIC1 STAT6 PIGQ ATXN1 PKHD1 ASTN2 C12orf76 MYBPC3	3.98e-03	1242	148	14	EFO_0007878
Disease	coagulation factor measurement	CFH VWF	4.47e-03	20	148	2	EFO_0004634
Disease	cortisol measurement	ZFP42 LDLR	4.47e-03	20	148	2	EFO_0005843
Disease	blood lead measurement	NTRK3 XDH CPB1	4.49e-03	66	148	3	EFO_0007040
Disease	asthma	DOCK3 NEMP1 LAYN CDK12 CASR VWA7 STAT6 RYBP LRP1 MUC2	4.72e-03	751	148	10	MONDO_0004979
Disease	central corneal thickness	COL12A1 RNF183 FBN2 ATXN1 ADAMTS18 ADAMTS20	4.79e-03	309	148	6	EFO_0005213
Disease	Antimigraine preparation use measurement	LRP1 ASTN2	4.93e-03	21	148	2	EFO_0009939
Disease	quinolinic acid measurement	BTBD3 RYBP	4.93e-03	21	148	2	EFO_0010528
Disease	cardiovascular system disease (is_implicated_in)	CFH XDH	4.93e-03	21	148	2	DOID:1287 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CDFEQDPCGWRDIST	MAMDC4	66	Q6UXC1
VWTRPDCAETEFENG	AGBL5	56	Q8NDL9
CSDERGWAENPLVYC	MLLT6	11	P55198
TGPWFCRKCESQERA	MLLT6	46	P55198
ECTSAGCFPKSWVER	BTNL10	166	A8MVZ5
FWDCFCFTEEIPIRN	AASDHPPT	291	Q9NRN7
ERYTPAIDVWSCGCI	CDK12	911	Q9NYV4
AGISWRSEACRENCE	CAGE1	271	Q8TC20
NRQCADCGSSRPDWA	ARAP3	501	Q8WWN8
RESCGARCVLPWAEF	CBLC	161	Q9ULV8
SPCWECSQAIREFLS	APOBEC1	91	P41238
AETQDSRGCARWCPQ	ADGRE2	21	Q9UHX3
GHWVETRDCFLQQCP	ADGRB1	506	O14514
EAVPEGDWFCTVCLA	BAZ2A	1711	Q9UIF9
ETDASACNKCPDDFW	CASR	576	P41180
ETLCSGFCLWREGDQ	ACOT11	526	Q8WXI4
QSCLFEEPDLTQRCW	BTBD3	231	Q9Y2F9
NGWSDLPICYERECE	CFH	556	P08603
GWSSCCPERTSQLFD	ATXN1	656	P54253
VIEDWCRCDSTAFGA	ASTN1	1006	O14525
WCRCDLSAFDANGLP	ASTN2	1046	O75129
EKREDPSCVDFFNWC	ADAMTS18	1181	Q8TE60
RVTRENCNEFSCPSW	ADAMTS20	1011	P59510
WAIACFAPQRQCTEV	AGO2	451	Q9UKV8
EVFLCCEQGWPARLA	RFT1	486	Q96AA3
EKTHGCPEWREECSF	RAB11FIP5	61	Q9BXF6
ERPTGCSIEQAWCLY	MFSD8	396	Q8NHS3
EWSCVRCTFLNPAGQ	CAPN15	6	O75808
PREAQCGFFEWADLS	NEIL3	536	Q8TAT5
PTASEESCRQRGCLW	MGAM2	921	Q2M2H8
RLFNPSGNDFCIWCE	NTRK3	711	Q16288
CDLPRGDFEAVWDCA	LGR6	756	Q9HBX8
GDWSQPCLTCDRAAR	EPN2	241	O95208
SCTCPTGFALAWDDR	HMCN2	4651	Q8NDA2
DAFRCFCPSGWEGEL	JAG2	656	Q9Y219
RNWYVDEPSCGSEVC	LAYN	136	Q6UX15
ERTSLCYAPSWVCDG	LRP1	2661	Q07954
RSDCPFWVTPESCDV	CFAP65	691	Q6ZU64
GAWRCDGFPECDDQS	LRP5	1276	O75197
WRETDFFPCSATCGG	ADAMTSL1	301	Q8N6G6
RCQPDGSVASCWPEA	CDH24	616	Q86UP0
IFDDGRCVSNCPSWK	PCSK5	911	Q92824
RCVSNCPSWKFEFEN	PCSK5	916	Q92824
KADPRFECGWCVAER	PLXNA1	821	Q9UIW2
ECTKEGACVFWRTPD	MUC2	1101	Q02817
ELREFCNSPDCSAWK	NEMP1	361	O14524
SDNTIRLWDIECGAC	FBXW11	421	Q9UKB1
PEEECLALNSTWGCF	GP2	196	P55259
DCSLSVGDPWRQCEA	NOTCH3	1416	Q9UM47
PDFTCVCDLGWTSDL	MEGF8	1131	Q7Z7M0
WAFLSCPPEDECANG	MEGF8	2171	Q7Z7M0
CTQALEDSGECRVWA	MYRFL	166	Q96LU7
PELVNEGWTCSRCAA	KDM4B	776	O94953
WRDCPSGFSVRENCS	LMLN2	321	A0A1B0GTW7
CFTGEIDCIPVAWRC	LRP6	1256	O75581
IDCIPVAWRCDGFTE	LRP6	1261	O75581
DEDDRTAEWVRPCRC	MARCHF5	21	Q9NX47
GFCPIKSNDCETFWD	MRC2	226	Q9UBG0
FCAGRECQPRWETSS	ADAMTSL2	616	Q86TH1
GRTCSECQELFWGDP	LAMB1	1111	P07942
FWGDPDVECRACDCD	LAMB1	1121	P07942
VEWSGDYSLCPRCTQ	KMT2B	1316	Q9UMN6
FAWESADSGLEVCPE	PGGHG	346	Q32M88
NFLAVCDPDWSRVNC	PLPP2	126	O43688
NPCCDWFLATASVDQ	DDB2	251	Q92466
CADLWPATRQEAVDC	MROH1	976	Q8NDA8
ELSPACAEVVWRCGN	OBSCN	1831	Q5VST9
FWERAGCKEPCIITA	PALB2	876	Q86YC2
APAVCCWRLFGERDA	NKX3-2	46	P78367
ERCFLSWFCDDILSP	APOBEC3F	251	Q8IUX4
SWSPCPECAGEVAEF	APOBEC3F	276	Q8IUX4
CVCRPGGEEEWVDSS	ATP13A2	296	Q9NQ11
PQCWAEGRCLLFDDS	ASPHD2	311	Q6ICH7
DDFPELCCRAWDCFV	ATR	1186	Q13535
DFRCVCNFSEPQPDW	CD14	31	P08571
ATWFACCDLEESFPV	DNAH6	3416	Q9C0G6
VEVFDPIANCWERCR	KLHL18	306	O94889
SWEFGIPLCRELACQ	DOCK3	1306	Q8IZD9
CEDDWNSGERFTCTV	IGHM	291	P01871
FCEELCNDLFNPSWE	BTAF1	286	O14981
CLPDGTWRQGDVECQ	C6	686	P13671
FDIVCSPVWTSRDRC	COL12A1	2706	Q99715
VDNVSARVAPWCDCG	GFRA4	206	Q9GZZ7
SDTWADEDRCCELPA	COL20A1	1036	Q9P218
DWRAQVGCEITCPEN	FCGBP	4341	Q9Y6R7
PFWNDISQCGRRDCA	ERO1A	86	Q96HE7
QSEECLWVGVRSPCS	MARCHF10	296	Q8NA82
RTKFDCVENGWPSVC	ITGA4	481	P13612
SACSDSWRVDDCPES	KRTAP10-5	11	P60370
SLYRGCQEICWEPTS	KRTAP13-2	51	Q52LG2
FSEPCDCSGQVEIWL	DNAH9	1666	Q9NYC9
AAWGSPCERCELDTA	FBN2	926	P35556
RLTSEPEGDWFCPEC	ZMYND8	116	Q9ULU4
AGWCEIGASRNPCDE	CPB1	256	P15086
EGACVWIPCTYRALD	CD22	36	P20273
NERCIPSVWRCDEDD	LRP8	56	Q14114
CIPERWVCDRQFDCE	LRP8	221	Q14114
RDGLCAWSEEECRNF	MIER2	296	Q8N344
DDRFVVACSAWKSCP	CROT	571	Q9UKG9
IQDWRDDFPACTDKC	OTOGL	376	Q3ZCN5
TCVDGDNWYRCECAP	JAG1	796	P78504
EVEYGPCVVASDCWS	MED20	141	Q9H944
ENLARGTCEIFAWCP	P2RX5	156	Q93086
GTCEIFAWCPLETSS	P2RX5	161	Q93086
CPEDWGASSRTSLCF	MRC1	646	P22897
AWFANCEDDITCGPT	RTBDN	121	Q9BSG5
FPVNTLQEWADTCCR	RASL10B	66	Q96S79
CSQICDPRTTGAFWQ	XAB2	691	Q9HCS7
FPSGDWICTFCRDIG	TRIM33	921	Q9UPN9
FCNRTVSDCCPDFWD	TINAGL1	76	Q9GZM7
GRELEAECPVCWNPF	RNF183	6	Q96D59
ECILAQDPVCAWSFR	SEMA4F	521	O95754
QDPVCAWSFRLDECV	SEMA4F	526	O95754
EECFTEACVQRWPCL	SCN4A	991	P35499
GECTPRGWRCDQEED	SSPOP	1576	A2VEC9
QACFTAACPVDGEWS	SSPOP	1741	A2VEC9
CRCVEVDVWDGPSGE	PLCD4	331	Q9BRC7
ECADDCWQRAVEPGR	RNF187	51	Q5TA31
DQDAWVPRADLTCGC	NTN5	406	Q8WTR8
VSEPCVCANWDFECD	SORCS3	741	Q9UPU3
NDECPIEWFHFSCVG	ING1	371	Q9UK53
WCHCRQEPEESLGRF	PIGQ	66	Q9BRB3
AKPAADEGFWDCSVC	RYBP	16	Q8N488
DFDSATCFGELQWCP	PPARGC1B	51	Q86YN6
QCEEGWVGPTCEERS	TENM1	711	Q9UKZ4
TDLWETCVRCFGDLQ	PKHD1	661	P08F94
CEVWTAESLFPCRVC	PHF24	136	Q9UPV7
TGSSACPWDGRCEQD	EXTL1	241	Q92935
CTRDGPSDCVLAADW	STRC	161	Q7RTU9
GWFPSDCLEEVANRS	SHANK1	601	Q9Y566
CVCSDERGWAENPLV	MLLT10	26	P55197
WENSRALCSAPACDI	CHST4	126	Q8NCG5
AEAVEPDGCVQSWRC	C12orf76	26	Q8N812
EPDLARGRWACQSCT	RNF31	346	Q96EP0
LFPWTCRGCGQELEE	ZNF513	311	Q8N8E2
TKAFECPECGQTFRW	ZNF707	201	Q96C28
TWFCECNQRFPSEDA	ZNF451	471	Q9Y4E5
IACTFCGQDEWSPER	TAS1R3	536	Q7RTX0
CGQDEWSPERSTRCF	TAS1R3	541	Q7RTX0
ECNECWRSFGERSDL	ZNF436	391	Q9C0F3
RPFICDSDSCGWTFT	ZXDC	356	Q2QGD7
CQPLECARCWTEYGI	TSNARE1	26	Q96NA8
QRTIWERPYECNECG	ZNF334	536	Q9HCZ1
TNGVCVDWRTPDFCA	VWF	2186	P04275
WCTISCRFNQEEGVG	RNF123	151	Q5XPI4
VEVDGWDCSFPRDAS	TUT1	466	Q9H6E5
SQPWEFLVGSDAFCC	STAT6	36	P42226
VAVDFSATWCGPCRT	TXNDC2	471	Q86VQ3
PECECIDWSERRNAV	TMEM50B	11	P56557
EGFTLPRCWEECLAS	XDH	961	P47989
FGQWSEVEPQCCGEA	RPS6KL1	431	Q9Y6S9
PWSSCSRDCELGFRV	SEMA5B	861	Q9P283
EPVSAVWALCDGYVC	ZFP42	41	Q96MM3
QSNHICFWEECPREG	ZIC1	266	Q15915
SVPSEDEWYCPECRN	UHRF1	351	Q96T88
QGSDCDIWDGQPVCR	WFIKKN1	101	Q96NZ8
SSLGCWCGVEDEAAP	ZNF552	51	Q9H707
DCPWCNAVNFSRRDT	TEX13A	381	Q9BXU3
CTRDGPSDCVLAADW	STRCP1	161	A6NGW2
CSCRNAADDDWGPEP	TGM1	51	P22735
CPRDCVVSEFLPWSN	THSD7B	176	Q9C0I4
VPCREDCTFTAWSKF	THSD7B	866	Q9C0I4
GPREAFSQLWELCCR	ZSCAN29	31	Q8IWY8
DCEELSCPRNWLGFT	VWA7	211	Q9Y334
SWFPVEGLADICQCC	POMZP3	146	Q6PJE2
SCGFTPDVKVWEVCF	TBL2	246	Q9Y4P3
VFRAATDQCPAAEGW	TRIO	2591	O75962
PDCEDGSDEWPQRCR	LDLR	171	P01130
VEYCPEGCSEWVAAL	MYBPC3	906	Q14896