Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcollagen-containing extracellular matrix

THSD4 HAPLN4 CFP ADAMTS8 ADAMTS4 SSPOP

1.01e-05530216GO:0062023
GeneOntologyCellularComponentextracellular matrix

THSD4 HAPLN4 CFP ADAMTS8 ADAMTS4 SSPOP

3.38e-05656216GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

THSD4 HAPLN4 CFP ADAMTS8 ADAMTS4 SSPOP

3.44e-05658216GO:0030312
DomainTSP_1

ADGRB2 THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

2.07e-1163186PF00090
DomainTSP1_rpt

ADGRB2 THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

2.52e-1165186IPR000884
DomainTSP1

ADGRB2 THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

2.52e-1165186PS50092
DomainTSP1

ADGRB2 THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

2.52e-1165186SM00209
DomainADAM_spacer1

THSD4 ADAMTS8 ADAMTS4

1.32e-0623183IPR010294
DomainADAM_spacer1

THSD4 ADAMTS8 ADAMTS4

1.32e-0623183PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS8 ADAMTS4

2.39e-0424182IPR013273
DomainADAM_Cys-rich

ADAMTS8 ADAMTS4

3.04e-0427182IPR006586
DomainACR

ADAMTS8 ADAMTS4

3.04e-0427182SM00608
DomainPep_M12B_propep

ADAMTS8 ADAMTS4

6.36e-0439182PF01562
DomainPeptidase_M12B_N

ADAMTS8 ADAMTS4

6.36e-0439182IPR002870
DomainDISINTEGRIN_1

ADAMTS8 ADAMTS4

6.70e-0440182PS00427
DomainReprolysin

ADAMTS8 ADAMTS4

6.70e-0440182PF01421
DomainADAM_MEPRO

ADAMTS8 ADAMTS4

6.70e-0440182PS50215
DomainDISINTEGRIN_2

ADAMTS8 ADAMTS4

6.70e-0440182PS50214
DomainPeptidase_M12B

ADAMTS8 ADAMTS4

6.70e-0440182IPR001590
DomainDisintegrin_dom

ADAMTS8 ADAMTS4

7.04e-0441182IPR001762
Domain-

ADAMTS8 ADAMTS4

2.72e-03811823.40.390.10
DomainMetalloPept_cat_dom

ADAMTS8 ADAMTS4

2.72e-0381182IPR024079
DomainZINC_PROTEASE

ADAMTS8 ADAMTS4

3.95e-0398182PS00142
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

1.57e-1039135MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

1.57e-1039135M27417
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

2.81e-0968135M27303
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

3.09e-08109135MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

3.38e-08111135M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

1.21e-07143135M27275
PathwayREACTOME_DISEASES_OF_METABOLISM

THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

1.93e-06250135M27554
Pubmed

Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

1.01e-231225810433963
Pubmed

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

2.62e-231325817668377
Pubmed

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

3.15e-22825717588759
Pubmed

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

4.72e-211025717984056
Pubmed

Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

6.74e-20132577739628
Pubmed

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

7.63e-191725711245978
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADGRB2 THSD4 CFP ADAMTS8 ADAMTS4 SSPOP

1.41e-117525620637190
Pubmed

The homeobox transcription factor DUXBL controls exit from totipotency.

DUX4L2 DUX4L4 DUX4L9

1.31e-09425338509386
Pubmed

Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.

DUX4L2 DUX4L4 DUX4L9

1.31e-09425317911620
Pubmed

Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.

DUX4L2 DUX4L4 DUX4L9

3.28e-09525320063414
Pubmed

The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.

DUX4L2 DUX4L4 DUX4L9

1.15e-08725330765463
Pubmed

Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.

DUX4L2 DUX4L4 DUX4L9

1.48e-071525335727972
Pubmed

Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.

DUX4L2 DUX4L4 DUX4L9

1.48e-071525330071041
Pubmed

Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.

DUX4 DUX4L9

4.96e-07225224145033
Pubmed

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.

ADAMTS8 ADAMTS4

2.97e-06425217606262
Pubmed

DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.

DUX4 DUX4L9

2.97e-06425219829708
Pubmed

RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.

DUX4L2 DUX4

4.95e-06525219359275
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

DUX4L2 DUX4L4 DUX4L9

6.29e-065025331806660
Pubmed

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

ADAMTS8 ADAMTS4

9.35e-052025219922873
Pubmed

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.

ADAMTS8 ADAMTS4

3.43e-043825218267097
Pubmed

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.

HAPLN4 RELT

4.20e-044225232738194
Pubmed

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.

LONP1 GLS

5.04e-044625235237793
InteractionADAMTS8 interactions

ADAMTS8 ADAMTS4

7.52e-065182int:ADAMTS8
CytobandEnsembl 112 genes in cytogenetic band chr4q35

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

1.45e-15117258chr4q35
Cytoband4q35.2

DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

4.00e-15272564q35.2
Cytoband15q23

THSD4 GRAMD2A

2.66e-044425215q23
CytobandEnsembl 112 genes in cytogenetic band chr15q23

THSD4 GRAMD2A

6.34e-0468252chr15q23
GeneFamilyPRD class homeoboxes and pseudogenes

DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 DUX4L9

5.14e-1292207521
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS8 ADAMTS4

1.97e-041920250
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAM114A1 ADAMTS8 RELT

1.65e-05118193d7dcffc0476a6e471debd83904a6569c6f27a594
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

HAPLN4 CFP RELT

5.09e-05172193200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADGRB2 CFP GRIN2D

5.26e-0517419316204ff504b7b382b4d90ca35003ad5336020e07
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFP RELT VMO1

5.45e-05176193f3bbe8c1a8d132705eac360cf531261271d84588
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THSD4 ADAMTS8 CCER1

5.54e-05177193928118b0ed120ec01c7d753ce523ab609ac24e5f
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADGRB2 THSD4 ADAMTS8

5.63e-051781938ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADGRB2 THSD4 ADAMTS8

5.63e-051781936c91331196696e0cf239d105f458e3230659fa38
ToppCell10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

THSD4 RELT VMO1

5.73e-05179193c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFP RELT VMO1

7.05e-051921937bcdbd97fa8c3bfccde426d44979601226913fc3
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFP RELT VMO1

7.38e-05195193157f1f9b0521c9eba11806eb4b6802ff116ab912
ToppCellfacs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 FAM114A1 ADAMTS4

7.38e-0519519318b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Nonclassical_Monocyte|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFP RELT VMO1

7.38e-0519519395327f2818bcdca53dbd2971f674a9042a1392c6
ToppCell(001)_CD16+_Monocyte|World / immune cells in Peripheral Blood (logTPM normalization)

CFP RELT VMO1

7.49e-0519619333843d550cbca03c044d593b1f6972e4d3871f7f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFP RELT VMO1

7.49e-0519619329246378ffb1010fe6858da756ae3d13df2306ba
ToppCell3'_v3-Lung-Myeloid_Monocytic-Nonclassical_monocytes|Lung / Manually curated celltypes from each tissue

CFP RELT VMO1

7.49e-051961937fe97109a5a06b35fc081a85f341ea78da131323
ToppCellMultiple_Sclerosis-Myeloid-CD16_Mono|Multiple_Sclerosis / Disease, Lineage and Cell Type

CFP RELT VMO1

7.49e-0519619383011b56780295dff5ded57064b07dcd2f19ea26
ToppCellCOVID-19_Severe-Non-classical_Monocyte|COVID-19_Severe / disease group, cell group and cell class

CFP RELT VMO1

7.49e-05196193af9e8f5ef9d03862f707e105857309b55595b1b9
ToppCellremission-Non-classical_Monocyte|remission / disease stage, cell group and cell class

CFP RELT VMO1

7.49e-05196193049d995986c20ce066bd64fcc2d2f1c2f8899883
ToppCellCOVID-19_Severe-Myeloid-Non-classical_Monocyte|COVID-19_Severe / Disease group, lineage and cell class

CFP RELT VMO1

7.61e-05197193c5837b9a5a39a0f607a4e217ade9fc87d82a5406
ToppCellCOVID-19_Severe-Non-classical_Monocyte|World / disease group, cell group and cell class

CFP RELT VMO1

7.61e-0519719360fee75b12451206bb2c07b61651a73c59ec6ade
ToppCellHealthy/Control-Non-classical_Monocyte|World / Disease group and Cell class

CFP RELT VMO1

7.61e-05197193470784932e1fc3ff69f27cd83f56d85b0c01af63
ToppCellmild_COVID-19-Non-classical_Monocyte|World / disease group, cell group and cell class (v2)

CFP RELT VMO1

7.61e-05197193368644260f70895052a1d71171a9d882315354dd
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.72e-051981939b8679b3dd8f4220d71f607b7080cb88d6e71129
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.72e-051981938b6b602ebe59b6dca6a22f17385d3160ff3ac67e
ToppCellHealthy-Non-classical_Monocyte|Healthy / disease group, cell group and cell class

CFP RELT VMO1

7.72e-05198193394e5fa8998c46c6f7cd57b53f347d2029c75ae1
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFP RELT VMO1

7.72e-051981939b47585653aaebd033c9b7bba93c7a7c35a4d60e
ToppCellControl_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|Control_saline / Treatment groups by lineage, cell group, cell type

CFP RELT VMO1

7.72e-05198193c15ab0660a6de445a83396cf70860ea39868914d
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFP RELT VMO1

7.72e-051981935436c3ed16e10e00c686f1ab0b0a68728a1a9985
ToppCellmild_COVID-19-Non-classical_Monocyte|mild_COVID-19 / disease group, cell group and cell class (v2)

CFP RELT VMO1

7.72e-05198193d7620b8d24e04ce1c563fc0ebe1625e03fe78950
ToppCellremission-Non-classical_Monocyte|World / disease stage, cell group and cell class

CFP RELT VMO1

7.72e-051981931c170655070acca00520b7cf9c510a04c0a90a8f
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFP RELT VMO1

7.72e-05198193115f564af8d7b89ac0331d3831faaef694043fd4
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFP RELT VMO1

7.72e-051981938b5d30312bbcabc6911ff03e5028766d77203dff
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.72e-05198193b9030390316baf456135f85f831394e1e11ecf3e
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.72e-05198193cbbdd44dfa95370c0fbaa65ba71d86bfee0ea379
ToppCellControl-Myeloid-Non-classical_Monocyte|Control / Disease group, lineage and cell class

CFP RELT VMO1

7.72e-05198193ae0a51e63e2751a6d9dc0c8a3852680949173523
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.72e-051981937d8fade2583c07a33dd83057cbce08e9fc77987a
ToppCellHealthy_donor-Non-classical_Monocyte|World / disease group, cell group and cell class (v2)

CFP RELT VMO1

7.72e-051981938a97c8b2a43e6d1e669ce18752841e2006744bd9
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFP RELT VMO1

7.72e-051981933bc3dbd178043deadd7eef413b2761dc003abd6e
ToppCellHealthy_donor-Non-classical_Monocyte|Healthy_donor / disease group, cell group and cell class (v2)

CFP RELT VMO1

7.72e-05198193d4eae333fa100db3ea2d4cbe7a1d6ab14816f0e2
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFP RELT VMO1

7.72e-051981934f67067d8142ca11b2d80195dac8d62a8d24d52c
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CFP RELT VMO1

7.72e-05198193c4a004f211f72f28aacbb512c6e075cbd049be53
ToppCellHealthy/Control-Non-classical_Monocyte|Healthy/Control / Disease group and Cell class

CFP RELT VMO1

7.72e-051981930badaf1fa5328d06291c3624d0f63196ffc81527
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells-mDC|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CFP RELT VMO1

7.72e-05198193e8002972410e4803d85263ba2642e6855cef83e9
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.72e-05198193165d60b111a17d517a420c434733eefb98da240d
ToppCellControl_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages|Control_saline / Treatment groups by lineage, cell group, cell type

CFP RELT VMO1

7.72e-05198193684f2dd5db889f118b5218ee23733cc1361272c2
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CFP RELT VMO1

7.72e-05198193ba3b97bb3e1533df758e845bde7d82eb1525b057
ToppCellPBMC-Severe-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFP RELT VMO1

7.72e-05198193d36a3cda7e5f385d2391e9b0dfb027d3c4549320
ToppCellControl_saline-Hematopoietic_Myeloid|Control_saline / Treatment groups by lineage, cell group, cell type

CFP RELT VMO1

7.84e-051991936be92062cce049a4c98f7311f2500bf1468fc267
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.84e-051991933e09b3c2e2c57e5248981293020d2434e898e3e1
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFP RELT VMO1

7.84e-05199193ae6b4b4557c6a9223acdee2a79bc780c5916d38a
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.84e-0519919399eec995aa20ac22a8dd045382bd15a15db0b87a
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFP RELT VMO1

7.84e-051991934eed28ef8c74d7131eeeabdd732a682d91e034dd
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP RELT VMO1

7.84e-05199193f234533254fd82b1ef2041e8405fe201d874018b
ToppCellCOVID-19_Convalescent-Myeloid-Non-classical_Monocyte|COVID-19_Convalescent / Disease group, lineage and cell class

CFP RELT VMO1

7.84e-051991935253948a1d7fc3da571860e14cdde4e18222e13b
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFP RELT VMO1

7.84e-05199193aca9f75c690c6ed952bcbdc7e1e7eef7719f54ca
ToppCellCOVID-19-COVID-19_Severe-Myeloid-CD16+_Monocyte|COVID-19_Severe / Disease, condition lineage and cell class

CFP RELT VMO1

7.96e-0520019358fbb7fc7159cbc417e6b457d60b7beba9b90da6
ToppCellCOVID-19-COVID-19_Mild-Myeloid-CD16+_Monocyte|COVID-19_Mild / Disease, condition lineage and cell class

CFP RELT VMO1

7.96e-052001935c0eb14bdf1bfeaf93f6c3d521529bd5a4de50ce
ToppCellCOVID-19-COVID-19_Convalescent-Myeloid-CD16+_Monocyte|COVID-19_Convalescent / Disease, condition lineage and cell class

CFP RELT VMO1

7.96e-05200193f24abb2d54d6423ee886285e3c66a874ec59e1a3
ToppCellMS-Multiple_Sclerosis-Myeloid-CD16+_Monocyte|Multiple_Sclerosis / Disease, condition lineage and cell class

CFP RELT VMO1

7.96e-05200193add2f9fbada3a68662edc8c756af90cdc380295b
ToppCellControl-Control-Myeloid-CD16+_Monocyte|Control / Disease, condition lineage and cell class

CFP RELT VMO1

7.96e-052001938dd124a5aca897652ea68efbfc5a167b4cf31aef
ToppCellmild-Non-classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CFP RELT VMO1

7.96e-05200193334bab6bf93d455f3526e817ea5785d8b6ee531c
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)--|Striatum / BrainAtlas - Mouse McCarroll V32

VMO1 SYNE4

5.37e-0481192c9145c994abcf49e5492270b18b0580a3d771ccf
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)|Striatum / BrainAtlas - Mouse McCarroll V32

VMO1 SYNE4

5.37e-0481192f84bfa55c6b9548f8829b16a145690d207a7bfc1
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Notum_(Notum)-|Striatum / BrainAtlas - Mouse McCarroll V32

VMO1 SYNE4

5.37e-048119234d2a2c30c749bd2ad447dfb1e43444953d9b154
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 SYNE4

7.22e-049419200b932421d77f0fd8d6ffe439c992ebc95ad7c94
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1|Striatum / BrainAtlas - Mouse McCarroll V32

ADAMTS4 SSPOP

1.10e-03116192c19974992b315fb873664fe3f5077ff8e907e30c
ToppCellLV-03._Atrial_Cardiomyocyte|LV / Chamber and Cluster_Paper

THSD4 HAPLN4

1.17e-031201923b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCellControl-Endothelial-Endothelial-Activated_Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CARS1 RELT

1.19e-03121192a5962d1c476e6966870832b72d511607e047248b
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAMD2A GRIN2D

1.29e-03126192cde3b0fbdc324120e45e295eb171ee550653de47
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAMD2A GRIN2D

1.33e-03128192082b3dc312b033c9b21cf73499009a1dc049ee2b
ToppCellLV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

THSD4 HAPLN4

1.37e-03130192a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_mature_2|E18.5-samps / Age Group, Lineage, Cell class and subclass

ADGRB2 SYNE4

1.39e-03131192f2eee150f5cff852e8f52f09b35e26f17d80833b
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADAMTS4 SSPOP

1.41e-03132192dc6edfa821a1cdc645668b0af5ba5ff80dee10bd
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-mDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELT VMO1

1.41e-03132192f8e2ba53063007d7507f1837ad669b0e4333cd23
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADAMTS4 SSPOP

1.41e-0313219260ced08bda5efc95a6f116cd0c6d1a779d99ed38
ToppCellStriatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Striatum / BrainAtlas - Mouse McCarroll V32

HAPLN4 GRIN2D

1.44e-03133192d5326a6ccada5ae6d3e8f7d4a858c90050e23c5b
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS4 SSPOP

1.46e-031341923dd4b5eddc94c1d49ab23b287ee234db3a55331b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAM114A1 ADAMTS8

1.48e-0313519254b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS4 SSPOP

1.52e-03137192b03f19b233c1c809f2cd2b4a7642eeaf254a6289
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

THSD4 ADAMTS4

1.52e-03137192b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADAMTS4 SSPOP

1.52e-031371925e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GRAMD2A CFP

1.54e-0313819286435f004f7525630d0cc0626b553d7adfc9db19
ToppCellfacs-Aorta-Heart-3m-Myeloid-professional_antigen_presenting_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAPLN4 SSPOP

1.57e-03139192292533e04178dd36d57377562077f9deb2cb9746
ToppCellfacs-Aorta-Heart-3m-Myeloid-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAPLN4 SSPOP

1.57e-0313919222a769d5195ed761ef333ef542746e1ba617a698
ToppCelldroplet-Liver-LIVER_NPC-30m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VMO1 SYNE4

1.59e-0314019239083c3e288d1878fdc4c798e600fb156daff8a9
ToppCelldroplet-Liver-LIVER_NPC-30m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VMO1 SYNE4

1.59e-0314019206e14a375ea85175c809ff5a0ea16e865ccb4ad5
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pappa2_(Mural.Rgs5Acta2.Pappa2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THSD4 ADAMTS8

1.61e-03141192a32947b13e888850c979a54c137512e4b96d2f36
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pappa2_(Mural.Rgs5Acta2.Pappa2)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

THSD4 ADAMTS8

1.61e-031411922cb651d63466fdcce011d1dd8de409ef439d03e7
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP RELT

1.63e-0314219239ada235a46f2202c093cf2336de224a5957ed1a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS8 RELT

1.68e-031441920bbe670454846cf9bc7464ae4e91488415c4111d
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFP VMO1

1.72e-03146192b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCellLPS_only-Myeloid-Dendritic_cells-mDC|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELT VMO1

1.75e-0314719226bd9d89e2e7b841cc18030bb7cebb642b987183
ToppCellLPS_only-Myeloid-Dendritic_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELT VMO1

1.77e-03148192cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

GRIN2D SYNE4

1.80e-031491926e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFP VMO1

1.84e-031511927b50425d2bbd7b6ff2a6e67d3e2470a4455740e0
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP RELT

1.87e-03152192bfc7ef4ee26165d18ac4f475a9519e8d52453ba2
ToppCellfacs-Lung-Endomucin-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP RELT

1.87e-03152192962f5bf632da79bd933193d3edd7d89941a85831
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HAPLN4 CFP

1.89e-031531925fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HAPLN4 CFP

1.89e-031531922c46183481e6d5a7fa190a743062509465f88e56
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

HAPLN4 CFP

1.89e-03153192decc4f3098a9374a6b65c015a9d36380986290bf
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

ADAMTS8 ADAMTS4

2.06e-03105192DOID:9352 (implicated_via_orthology)
DiseaseHMG CoA reductase inhibitor use measurement

HAPLN4 VMO1

6.50e-03189192EFO_0009932
Diseaseobesity (implicated_via_orthology)

ADAMTS8 ADAMTS4

8.33e-03215192DOID:9970 (implicated_via_orthology)
Diseaselongevity

CARS1 GLS

1.42e-02284192EFO_0004300

Protein segments in the cluster

PeptideGeneStartEntry
CPVEGQWLEWGPWGP

ADGRB2

416

O60241
PKPVADGGWAPWGPW

ADAMTS8

521

Q9UP79
DGGWAPWGPWGECSR

ADAMTS8

526

Q9UP79
PPTSQGSPWWGWGRG

DUX4L4

301

P0CJ87
GSPWWGWGRGPQVAG

DUX4L4

306

P0CJ87
PPTSQGSPWWGWGRG

DUX4L6

301

P0CJ89
GSPWWGWGRGPQVAG

DUX4L6

306

P0CJ89
GCWGGPWRPPPPGFW

CCER1

86

Q8TC90
AARLHPWWGGGGWPA

GLS

51

O94925
PWWGGGGWPAEPLAR

GLS

56

O94925
PPTSQGSPWWGWGRG

DUX4

301

Q9UBX2
GSPWWGWGRGPQVAG

DUX4

306

Q9UBX2
PPTSQGSPWWGWGRG

DUX4L3

301

P0CJ86
GSPWWGWGRGPQVAG

DUX4L3

306

P0CJ86
PWALWGRGPAIGGQW

LONP1

51

P36776
QCCPEMGGWSGWGPW

CFP

131

P27918
NIPQAGGWGPWGPWG

ADAMTS4

516

O75173
GGWGPWGPWGDCSRT

ADAMTS4

521

O75173
PPTSQGSPWWGWGRG

DUX4L9

301

Q6RFH8
GSPWWGWGRGPQVAG

DUX4L9

306

Q6RFH8
PPTSQGSPWWGWGRG

DUX4L7

301

P0CJ90
GSPWWGWGRGPQVAG

DUX4L7

306

P0CJ90
DPAPGGWGWGWAGGG

HAPLN4

371

Q86UW8
PPTSQGSPWWGWGRG

DUX4L5

301

P0CJ88
GSPWWGWGRGPQVAG

DUX4L5

306

P0CJ88
GRWAWPMPGWGPACP

GRAMD2A

261

Q8IUY3
PPSGGGWAGWGSWGK

FAM114A1

121

Q8IWE2
PSWPCPWGKGRPGWH

CARS1

331

P49589
DRAGGWGPWGPWSHC

SSPOP

3251

A2VEC9
PVDGAWGPWGPWSPC

SSPOP

3471

A2VEC9
WGPWGPWSPCDMCLG

SSPOP

3476

A2VEC9
WPGPGGVWGPWAPSS

SYNE4

226

Q8N205
GGPWGDWAWPEMCPD

VMO1

41

Q7Z5L0
GDCWPGWFGPWGVPR

RELT

91

Q969Z4
GAPGVWGAWGPWSAC

THSD4

51

Q6ZMP0
PPTSQGSPWWGWGRG

DUX4L2

301

P0CJ85
GSPWWGWGRGPQVAG

DUX4L2

306

P0CJ85
GLDGGWWAPPPPPWA

GRIN2D

1201

O15399