Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC12A6 TRPC4AP ANO10 PKD1L2 TMEM87A ABCC6 TFRC SLC32A1 CNNM4 P2RX1 P2RX4 KCNG1 SLC18A3 GLRA2 KCNJ12 KCNJ18 ABCC2 DMAC2L SLC23A1 SLC29A1

2.92e-0675816020GO:0015318
GeneOntologyMolecularFunctiontransporter activity

SLC12A6 TMEM144 TRPC4AP ABCA4 APOB ANO10 PKD1L2 TMEM87A ABCC6 CHRNE TFRC SLC32A1 CNNM4 P2RX1 P2RX4 ATAD1 KCNG1 SV2A SLC18A3 GLRA2 KCNJ12 LRP6 KCNJ18 ABCC2 DMAC2L SLC23A1 SLC29A1

3.95e-06128916027GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC12A6 TRPC4AP ANO10 PKD1L2 TMEM87A CHRNE TFRC SLC32A1 CNNM4 P2RX1 P2RX4 KCNG1 SLC18A3 KCNJ12 KCNJ18 DMAC2L SLC23A1 SLC29A1

6.58e-0666416018GO:0008324
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC12A6 TMEM144 TRPC4AP ABCA4 ANO10 PKD1L2 TMEM87A ABCC6 CHRNE TFRC SLC32A1 CNNM4 P2RX1 P2RX4 KCNG1 SV2A SLC18A3 GLRA2 KCNJ12 LRP6 KCNJ18 ABCC2 DMAC2L SLC23A1 SLC29A1

7.79e-06118016025GO:0022857
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DYNC2H1 DNAH7 DNAH11

1.11e-05181604GO:0008569
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC12A6 TRPC4AP ANO10 PKD1L2 TMEM87A CHRNE TFRC SLC32A1 CNNM4 P2RX1 P2RX4 KCNG1 SLC18A3 GLRA2 KCNJ12 KCNJ18 DMAC2L SLC23A1 SLC29A1

2.04e-0579316019GO:0015075
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC12A6 TRPC4AP PKD1L2 TMEM87A TFRC SLC32A1 CNNM4 P2RX1 P2RX4 KCNG1 SLC18A3 KCNJ12 KCNJ18 DMAC2L SLC23A1 SLC29A1

4.56e-0562716016GO:0022890
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DYNC2H1 DNAH7 DNAH11

7.00e-05281604GO:0051959
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A6 TRPC4AP PKD1L2 TMEM87A TFRC CNNM4 P2RX1 P2RX4 KCNG1 KCNJ12 KCNJ18 SLC23A1 SLC29A1

9.85e-0546516013GO:0046873
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 DYNC2H1 DNAH7 DNAH11

2.13e-04371604GO:0045505
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

CHRNE P2RX1 P2RX4 GLRA2

3.84e-04431604GO:0005231
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPC4AP ANO10 PKD1L2 TMEM87A CHRNE P2RX1 P2RX4 KCNG1 KCNJ12 KCNJ18

4.59e-0434316010GO:0005261
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

ANO10 CHRNE P2RX1 P2RX4 KCNJ12 KCNJ18

9.35e-041401606GO:0099094
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO10 CHRNE P2RX1 P2RX4 GLRA2 KCNJ12 KCNJ18

9.50e-041931607GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

ANO10 CHRNE P2RX1 P2RX4 GLRA2 KCNJ12 KCNJ18

1.07e-031971607GO:0022834
GeneOntologyMolecularFunctionchannel activity

SLC12A6 TRPC4AP ANO10 PKD1L2 TMEM87A CHRNE P2RX1 P2RX4 KCNG1 GLRA2 KCNJ12 KCNJ18

1.10e-0352516012GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC12A6 TRPC4AP ANO10 PKD1L2 TMEM87A CHRNE P2RX1 P2RX4 KCNG1 GLRA2 KCNJ12 KCNJ18

1.12e-0352616012GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPC4AP ANO10 PKD1L2 TMEM87A CHRNE P2RX1 P2RX4 KCNG1 GLRA2 KCNJ12 KCNJ18

1.21e-0345916011GO:0005216
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKACA PRKACG

1.31e-0371602GO:0004691
GeneOntologyMolecularFunctionextracellularly ATP-gated monoatomic cation channel activity

P2RX1 P2RX4

1.31e-0371602GO:0004931
GeneOntologyMolecularFunctiongated channel activity

ANO10 TMEM87A CHRNE P2RX1 P2RX4 KCNG1 GLRA2 KCNJ12 KCNJ18

1.52e-033341609GO:0022836
GeneOntologyMolecularFunctionABC-type glutathione S-conjugate transporter activity

ABCC6 ABCC2

1.73e-0381602GO:0015431
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC12A6 TRPC4AP F2RL3 ANO10 PKD1L2 CHRNE SLC32A1 CNNM4 P2RX1 P2RX4 TMEM168 KCNG1 SLC18A3 KCNJ12 PRKACA OSR1 CCR5 PLCB2 KCNJ18 ABCC2 DMAC2L SLC23A1

4.74e-0694216222GO:0098655
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC12A6 TRPC4AP F2RL3 ANO10 PKD1L2 ABCC6 CHRNE SLC32A1 CNNM4 P2RX1 P2RX4 TMEM168 KCNG1 SLC18A3 GLRA2 KCNJ12 PRKACA OSR1 CCR5 PLCB2 KCNJ18 ABCC2 DMAC2L SLC23A1

6.75e-06111516224GO:0034220
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC12A6 TRPC4AP F2RL3 ANO10 PKD1L2 SLC32A1 CNNM4 P2RX1 P2RX4 TMEM168 KCNG1 SLC18A3 GLRA2 KCNJ12 PRKACA OSR1 CCR5 PLCB2 KCNJ18 ABCC2 DMAC2L SLC23A1

1.58e-05101716222GO:0098660
GeneOntologyBiologicalProcessinterleukin-33-mediated signaling pathway

TRAF6 IRAK4 IL1RL1

2.59e-0581623GO:0038172
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC12A6 TRPC4AP F2RL3 ANO10 PKD1L2 CHRNE TFRC SLC32A1 CNNM4 P2RX1 P2RX4 TMEM168 KCNG1 SLC18A3 KCNJ12 PRKACA OSR1 CCR5 PLCB2 KCNJ18 ABCC2 DMAC2L SLC23A1

3.76e-05115716223GO:0006812
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC12A6 TRPC4AP F2RL3 PKD1L2 SLC32A1 CNNM4 P2RX1 P2RX4 TMEM168 KCNG1 SLC18A3 KCNJ12 PRKACA OSR1 CCR5 PLCB2 KCNJ18 ABCC2 DMAC2L SLC23A1

3.81e-0592216220GO:0098662
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC12A6 TRPC4AP F2RL3 ANO10 PKD1L2 ABCC6 CHRNE TFRC SLC32A1 CNNM4 P2RX1 P2RX4 TMEM168 KCNG1 SLC18A3 GLRA2 KCNJ12 PRKACA OSR1 CCR5 PLCB2 KCNJ18 ABCC2 DMAC2L SLC23A1

7.11e-05137416225GO:0006811
GeneOntologyCellularComponentaxoneme

DNHD1 DYNC2H1 DNAH7 ARL3 PRKACA CFAP206 HYDIN DNAH11

1.91e-042071598GO:0005930
GeneOntologyCellularComponentciliary plasm

DNHD1 DYNC2H1 DNAH7 ARL3 PRKACA CFAP206 HYDIN DNAH11

1.97e-042081598GO:0097014
DomainARM-type_fold

DOCK1 DOCK3 MROH9 TRPC4AP DNAJC13 NBEAL1 USP9X RNPEPL1 APOB MEI1 TRRAP SDAD1 URB1 CSE1L PSME4 DIAPH2 UNC79 STAG3 STAG2 PPP6R3

1.24e-1133916020IPR016024
DomainDynein_HC_stalk

DNHD1 DYNC2H1 DNAH7 DNAH11

4.86e-06141604IPR024743
DomainDynein_heavy_dom-2

DNHD1 DYNC2H1 DNAH7 DNAH11

4.86e-06141604IPR013602
DomainDHC_N2

DNHD1 DYNC2H1 DNAH7 DNAH11

4.86e-06141604PF08393
DomainMT

DNHD1 DYNC2H1 DNAH7 DNAH11

4.86e-06141604PF12777
DomainDHC_fam

DNHD1 DYNC2H1 DNAH7 DNAH11

6.58e-06151604IPR026983
DomainDynein_heavy

DNHD1 DYNC2H1 DNAH7 DNAH11

6.58e-06151604PF03028
DomainDynein_heavy_dom

DNHD1 DYNC2H1 DNAH7 DNAH11

6.58e-06151604IPR004273
DomainAAA

ABCA4 DYNC2H1 PSMC3 DNAH7 ABCC6 ATAD1 ABCC2 DNAH11

3.42e-051441608SM00382
DomainAAA+_ATPase

ABCA4 DYNC2H1 PSMC3 DNAH7 ABCC6 ATAD1 ABCC2 DNAH11

3.42e-051441608IPR003593
DomainK_chnl_inward-rec_Kir2.2

KCNJ12 KCNJ18

7.29e-0521602IPR003272
DomainARM-like

MROH9 DNAJC13 USP9X MEI1 TRRAP CSE1L PSME4 STAG3 STAG2 PPP6R3

1.15e-0427016010IPR011989
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH7 DNAH11

2.10e-04141603IPR024317
DomainAAA_8

DYNC2H1 DNAH7 DNAH11

2.10e-04141603PF12780
DomainK_chnl_inward-rec_Kir_N

KCNJ12 KCNJ18

2.18e-0431602IPR013673
DomainIRK_N

KCNJ12 KCNJ18

2.18e-0431602PF08466
DomainSCD

STAG3 STAG2

4.33e-0441602PS51425
DomainSCD

STAG3 STAG2

4.33e-0441602IPR020839
DomainSTAG

STAG3 STAG2

4.33e-0441602PF08514
DomainSTAG

STAG3 STAG2

4.33e-0441602IPR013721
DomainMultidrug-R_assoc

ABCC6 ABCC2

4.33e-0441602IPR005292
DomainDOCK_N

DOCK1 DOCK3

7.17e-0451602PF16172
DomainDOCK_N

DOCK1 DOCK3

7.17e-0451602IPR032376
DomainP2X_receptor

P2RX1 P2RX4

1.49e-0371602PF00864
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

1.49e-0371602IPR012345
DomainSTAT

STAT5A STAT5B

1.49e-0371602IPR001217
DomainP2X_purnocptor

P2RX1 P2RX4

1.49e-0371602IPR001429
DomainSTAT_int

STAT5A STAT5B

1.49e-0371602SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

1.49e-0371602IPR013801
DomainSTAT_bind

STAT5A STAT5B

1.49e-0371602PF02864
DomainSTAT_int

STAT5A STAT5B

1.49e-0371602PF02865
Domain-

STAT5A STAT5B

1.49e-03716021.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

1.49e-0371602PF01017
Domain-

P2RX1 P2RX4

1.49e-03716022.60.490.10
Domain-

STAT5A STAT5B

1.49e-03716021.20.1050.20
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

1.49e-0371602IPR013799
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

1.49e-0371602IPR015988
Domain-

STAT5A STAT5B

1.49e-03716022.60.40.630
DomainP2X_RECEPTOR

P2RX1 P2RX4

1.49e-0371602PS01212
DomainP2X_extracellular_dom

P2RX1 P2RX4

1.49e-0371602IPR027309
DomainSTAT_TF_alpha

STAT5A STAT5B

1.97e-0381602IPR013800
DomainDHC_N1

DYNC2H1 DNAH11

1.97e-0381602PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DNAH11

1.97e-0381602IPR013594
Domain-

MROH9 DNAJC13 USP9X TRRAP CSE1L PSME4 STAG3

3.07e-0322216071.25.10.10
DomainGPS

ADGRG5 PKD1L2 ADGRF4

3.30e-03351603PF01825
DomainGPS

ADGRG5 PKD1L2 ADGRF4

3.58e-03361603PS50221
DomainDHR-1_domain

DOCK1 DOCK3

3.81e-03111602IPR027007
DomainDHR_2

DOCK1 DOCK3

3.81e-03111602PS51651
DomainDHR_1

DOCK1 DOCK3

3.81e-03111602PS51650
DomainDHR-2

DOCK1 DOCK3

3.81e-03111602PF06920
DomainDOCK

DOCK1 DOCK3

3.81e-03111602IPR026791
DomainDOCK_C

DOCK1 DOCK3

3.81e-03111602IPR010703
DomainDOCK-C2

DOCK1 DOCK3

3.81e-03111602PF14429
DomainDHR-2

DOCK1 DOCK3

3.81e-03111602IPR027357
DomainGPS

ADGRG5 PKD1L2 ADGRF4

3.87e-03371603IPR000203
DomainABC_transporter_CS

ABCA4 ABCC6 ABCC2

5.55e-03421603IPR017871
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH11

6.20e-03141602IPR011704
DomainAAA_5

DYNC2H1 DNAH11

6.20e-03141602PF07728
DomainABC_tran

ABCA4 ABCC6 ABCC2

8.05e-03481603PF00005
DomainABC_TRANSPORTER_2

ABCA4 ABCC6 ABCC2

8.05e-03481603PS50893
DomainIRK

KCNJ12 KCNJ18

8.09e-03161602PF01007
DomainK_chnl_inward-rec_Kir_cyto

KCNJ12 KCNJ18

8.09e-03161602IPR013518
Domain-

KCNJ12 KCNJ18

8.09e-031616022.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ12 KCNJ18

8.09e-03161602IPR016449
DomainABC_TRANSPORTER_1

ABCA4 ABCC6 ABCC2

8.52e-03491603PS00211
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NAT14 CLGN EMC1 DYNC2H1 USP9X PSMC3 LRRC59 URB2 TFRC FANCD2 CNNM4 URB1 CSE1L NUP155 ATAD1 PXMP2 GEMIN4 LRP6 STAG2 PPP6R3

2.54e-089421652031073040
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1

3.37e-088165412634303
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

PI4K2B CLGN EMC1 DDX60 UGGT1 VPS8 PSMC3 LRRC59 TUBGCP4 SDAD1 TFRC FANCD2 CNNM4 UBE4A URB1 MAP7D1 CSE1L NUP155 ATAD1 GEMIN4 PSME3 STAG2 PPP6R3 ZC3HAV1

9.06e-0814401652430833792
Pubmed

Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression.

STAT5A STAT5B TFRC

1.05e-073165318552213
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TRPC4AP CLGN EMC1 PPFIA1 UGGT1 PSMC3 LCP1 TFRC FANCD2 CNNM4 MAP7D1 CSE1L NUP155 XRN1 GEMIN4 C3 PSME3 PPP6R3 ZC3HAV1

2.14e-079741651928675297
Pubmed

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

EMC1 ITSN1 GART PSMC3 LRRC59 TMEM87A STAT5A TFRC UBE4A CSE1L NUP155 XRN1 ZC3HAV1

2.62e-074491651331732153
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 EMC1 DYNC2H1 USP9X UGGT1 GART PSMC3 BCCIP APOB LRRC59 URB2 SDAD1 TFRC FANCD2 UBE4A URB1 CSE1L NUP155 PRKACA GEMIN4 PSME3 STAG2 ZC3HAV1

3.04e-0714251652330948266
Pubmed

Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ.

TRAF6 NFKBIZ IRAK4

4.18e-074165322059479
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP9X UGGT1 GART PSMC3 URB2 LCP1 TRRAP URB1 CSE1L NUP155 XRN1 GEMIN4 STAG2 PPP6R3 ZC3HAV1

5.88e-076531651522586326
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

MMS22L CLGN EMC1 USP9X GART PSMC3 TUBGCP4 TFRC FANCD2 MAP7D1 CSE1L PRKACA GEMIN4 PPP6R3 ZC3HAV1

6.35e-076571651536180527
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

CLGN USP9X GART PSMC3 TUBGCP4 TFRC URB1 CSE1L PRKACA GEMIN4 PSME3 ZC3HAV1

6.51e-074081651233766124
Pubmed

Stat5 expression is critical for mast cell development and survival.

STAT5A STAT5B IL1RL1

2.08e-066165312714518
Pubmed

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

STAT5A STAT5B PLCB2

2.08e-066165319647226
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DNAJC13 EMC1 DSC3 USP9X PPFIA1 UGGT1 PSMC3 SDAD1 FANCD2 CNNM4 CSE1L NUP155 PTPRZ1 PRKACA LRP6 CDK5RAP2 SLC29A1 PPP6R3

2.81e-0610491651827880917
Pubmed

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.

TRAF6 IRAK4 IL1RL1

3.62e-067165316286016
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PPFIA1 ITSN1 UGGT1 LGR4 NFKBIZ APOB ST3GAL2 URB1 PSME4 P2RX4 SYNJ1 IRAK4 NFYC CDK5RAP2 KLHDC10 SLC29A1 STAG2 VPS13B

4.42e-0610841651811544199
Pubmed

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

TRAF6 IRAK4 NHLH2 IL1RL1

5.72e-0625165419898481
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

SLC12A6 DNAJC13 EMC1 VPS8 TMEM87A NUP155 SV2A MTFR1 DIAPH2 SLC29A1 VPS13B ZC3HAV1

5.74e-065041651234432599
Pubmed

Genetic analysis of Down syndrome-associated heart defects in mice.

GART URB1 SYNJ1

5.77e-068165321442329
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

DOCK1 DSC3 NBEAL1 ITSN1 VPS8 TFRC SYNJ1 SV2A ZC3HAV1

9.64e-06285165934369648
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

PPFIA1 BCCIP TRRAP SDAD1 FANCD2 KLHL9 NUP155 MTFR1 PSME3 ZC3HAV1

1.04e-053641651024778252
Pubmed

Defining the membrane proteome of NK cells.

PI4K2B DNAJC13 USP9X PSMC3 LRRC59 ANO10 TUBGCP4 CSE1L NUP155 P2RX4 ATAD1 XRN1 PXMP2 GEMIN4 PARP9 PSME3 SLC29A1 STAG2

1.21e-0511681651819946888
Pubmed

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

STAT5A STAT5B TFRC

1.23e-0510165318694996
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DNAJC13 USP9X GART PSMC3 LRRC59 TFRC CSE1L NUP155 GEMIN4 PSME3 STAG2 PPP6R3 ZC3HAV1

1.23e-056381651333239621
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

DNAJC13 EMC1 PPFIA1 UGGT1 GART PSMC3 LGR4 BCCIP APOB LRRC59 URB2 TRRAP TFRC NUP155 PRKACA C3 KLHDC10 PPP6R3 ZC3HAV1

1.39e-0512971651933545068
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

DOCK1 USP9X UGGT1 TRRAP CSE1L DIAPH2 PSME3 STAG2

1.78e-05235165830258100
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

USP9X PSMC3 LRRC59 TBC1D24 TFRC FANCD2 URB1 CSE1L NUP155 PRKACA PSME3 PPP6R3

1.98e-055711651237167062
Pubmed

Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.

TFRC SLC32A1 SV2A

2.24e-0512165319144828
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

2.24e-052165223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

2.24e-052165226999798
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

2.24e-052165231443474
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

2.24e-052165212377952
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

2.24e-052165221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

2.24e-052165216289657
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

2.24e-052165225552366
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

2.24e-052165225470773
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

2.24e-052165221431790
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

2.24e-052165228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

2.24e-052165221826656
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

2.24e-05216527720707
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

2.24e-052165227264955
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

2.24e-052165222159083
Pubmed

Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits.

P2RX1 P2RX4

2.24e-052165224845338
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

2.24e-052165220008792
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

2.24e-052165233199496
Pubmed

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.

ZBTB20 C3

2.24e-052165218562603
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

2.24e-052165216502315
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

2.24e-052165212217382
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

2.24e-052165231599926
Pubmed

Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.

PSME4 PSME3

2.24e-052165227003159
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

2.24e-052165210594041
Pubmed

P2X1 and P2X4 receptor currents in mouse macrophages.

P2RX1 P2RX4

2.24e-052165217934511
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

2.24e-052165221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

2.24e-052165210486277
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

2.24e-052165216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

2.24e-052165215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

2.24e-052165230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

2.24e-052165223565285
Pubmed

Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility.

P2RX1 P2RX4

2.24e-052165217873021
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

2.24e-052165232790723
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

2.24e-052165218492722
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

2.24e-052165210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

2.24e-052165210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

2.24e-052165235464049
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

2.24e-052165218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

2.24e-052165223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

2.24e-05216528631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

2.24e-052165211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

2.24e-052165224878107
Pubmed

Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.

KCNJ12 KCNJ18

2.24e-052165215705530
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

2.24e-052165212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

2.24e-052165212835478
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

2.24e-05216527568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

2.24e-052165224497979
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

2.24e-052165217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

2.24e-052165217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

2.24e-052165217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

2.24e-052165210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

2.24e-052165217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

2.24e-052165224497923
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

2.24e-052165224335105
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

2.24e-052165229460051
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

2.24e-052165228606561
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

2.24e-052165212393407
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

2.24e-052165212039059
Pubmed

Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse.

STAT5A STAT5B

2.24e-052165221178171
Pubmed

Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets.

PRKACA PLCB2

2.24e-052165220591207
Pubmed

Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A.

LCP1 PRKACA

2.24e-052165210446213
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

2.24e-052165220233708
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

2.24e-052165216775227
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

2.24e-052165217447893
Pubmed

Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.

STAG3 STAG2

2.24e-052165227500726
Pubmed

Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11.

DYNC2H1 DNAH11

2.24e-05216529325061
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

2.24e-052165216115927
Pubmed

Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells.

PRKACA PRKACG

2.24e-052165215039079
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

2.24e-052165223275557
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

2.24e-052165211867689
Pubmed

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

STAT5A STAT5B

2.24e-052165215980098
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

2.24e-052165215340066
Pubmed

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

STAT5A STAT5B

2.24e-052165223660011
InteractionP2RY6 interactions

CLGN EMC1 UGGT1 VPS8 PSMC3 LRRC59 TUBGCP4 TFRC FANCD2 CNNM4 UBE4A CSE1L NUP155 GEMIN4 PPP6R3

5.35e-0738516215int:P2RY6
InteractionANKRD20A4P interactions

ANKRD20A2P ANKRD20A4P ANKRD20A1

1.00e-0561623int:ANKRD20A4P
InteractionS1PR4 interactions

CAV2 TMEM87A TBC1D24 FANCD2 CNNM4 GEMIN4 ABCC2 SLC29A1

1.52e-051371628int:S1PR4
InteractionANKRD20A2P interactions

ANKRD20A2P ANKRD20A4P ANKRD20A1

1.74e-0571623int:ANKRD20A2P
InteractionGPR17 interactions

MMS22L VPS8 TUBGCP4 TMEM87A FANCD2 UBE4A URB1 CSE1L GEMIN4 SLC29A1 STAG2

1.89e-0528316211int:GPR17
InteractionTLR9 interactions

TRAF6 CLGN UGGT1 FANCD2 KCNG1 XRN1

3.13e-05751626int:TLR9
InteractionUNC93B1 interactions

CLGN EMC1 UGGT1 VPS8 PSMC3 LRRC59 TFRC FANCD2 CNNM4 CSE1L ATAD1 GEMIN4 STAG2

3.38e-0541716213int:UNC93B1
Cytoband2q11.1

ANKRD20A8P ADRA2B GPAT2

1.40e-042816532q11.1
CytobandEnsembl 112 genes in cytogenetic band chr2q11

ANKRD20A8P CNNM4 ADRA2B GPAT2 REV1

2.40e-041531655chr2q11
GeneFamilyPurinergic receptors P2X

P2RX1 P2RX4

7.15e-0471072214
GeneFamilyCohesin complex

STAG3 STAG2

9.49e-04810721060
CoexpressionGSE14308_TH2_VS_NAIVE_CD4_TCELL_DN

DYNC2H1 TRRAP FBXO46 VSIR STAT5A CSE1L PARP9 TMEM35A STAG2 VPS13B

5.35e-0720016310M3365
CoexpressionGSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_HET_TCONV_DN

TTC39B TRAF6 TRPC4AP ZBTB20 NBEAL1 DNAH7 ADH1C IRAK4 XRN1 DIAPH2

5.35e-0720016310M5697
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_SMALL_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

DOCK3 MMS22L NAT14 TBC1D24 FANCD2 TMEM130 NUP155 PTPRZ1 CENPI SASS6 CDK5RAP2 KLHDC10 UNC79 SCAI REV1

2.41e-0568016315MM456
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DOCK1 DNAJC13 ZBTB20 USP9X PPFIA1 ITSN1 CAV2 TRRAP ZNF804A TMEM87A CSE1L PSME4 MTFR1 NFYC KLHDC10 STAG2 VPS13B

2.60e-0585616317M4500
CoexpressionGSE42088_UNINF_VS_LEISHMANIA_INF_DC_2H_UP

CLGN GART GRB10 ST3GAL2 LRRC59 ZNF804A AGTR2 C3

3.78e-052001638M9900
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

PIGB MMS22L DNAJC13 ZBTB20 UGGT1 TFRC URB1 CSE1L TMEM168

2.18e-08177165982fdd6185b368f54f03de389427cbe3071d21a99
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK3 MROH9 VSTM2B LRRTM3 TMEM130 LRP6 UNC79 HYDIN

8.06e-07199165819a97e27a4758e794ce7246d295e112b47931a48
ToppCellwk_15-18-Hematologic-Myeloid-HSC/ELP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ADGRG5 LCP1 CRHBP P2RX1 CNTN5 ANKRD20A1 PTGDR2

1.63e-061521657f2cedf16e826aad763bfee5e46444327482f9a53
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZBTB20 GRB10 ZNF804A SLC32A1 PTPRZ1 SLC18A3 GLRA2

3.69e-0617216577e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PI4K2B MMS22L ABCA4 CENPI SASS6 SLC23A1 DNAH11

4.30e-0617616573766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PI4K2B MMS22L ABCA4 CENPI SASS6 SLC23A1 DNAH11

4.30e-061761657aa1bada2175d8370fc71939a607407155259d195
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

PIGB DDX60 UGGT1 TFRC URB1 CSE1L TMEM168

4.30e-0617616573de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

ZBTB20 USP9X DDX60 NFKBIZ XRN1 PARP9 ZC3HAV1

5.55e-0618316578f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellControl-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ADRA2B ANKRD20A4P FHIP1A ANKRD20A1

5.75e-061841657c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

TTC39B MMS22L TMEM161B TUBGCP4 TFRC URB1 NUP155

5.96e-061851657a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

TTC39B MMS22L TMEM161B TUBGCP4 TFRC URB1 NUP155

6.17e-0618616578571956890fc9894d766ba294a28e376b4aba428
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 DDX60 PTPRZ1 GPC2 DNAH11

6.40e-061871657daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 DDX60 PTPRZ1 GPC2 DNAH11

6.40e-0618716575b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Myeloid|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MROH9 TMEM144 LCP1 CRHBP VSIR STAT5A C3

8.13e-0619416574f28841c7f37884fc34c6689cd6976c6559d23f1
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Myeloid-Microglia|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MROH9 TMEM144 LCP1 CRHBP VSIR STAT5A C3

8.13e-061941657459e836bcdb6742333684ac23d960efa5e99702f
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH7 CRHBP PTPRZ1 CFAP206 C3 HSD17B2 HYDIN

9.28e-061981657e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH7 CRHBP PTPRZ1 CFAP206 C3 HSD17B2 HYDIN

9.28e-061981657e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VSIR SLC32A1 P2RX1 QPRT IL1RL1 HSD17B2

1.98e-0514916565a5e9660f7d9b527f50a92d94d4c0c8aedb82c0b
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADGRG5 ST3GAL2 LCP1 ANKRD20A4P NEK8 ANKRD20A1

2.05e-05150165657f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages-T-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGRG5 MMS22L ST3GAL2 PLCB2 ZDHHC19 DMAC2L

2.75e-05158165691d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM144 CLTRN CHRNE ZDHHC19 GPAT2 SLC23A1

2.95e-051601656f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZBTB20 GRB10 ZNF804A PTPRZ1 SLC18A3 GLRA2

3.28e-051631656ec9a20cfe0d69430f9c68cddd1ab0e4a3e4554b8
ToppCell367C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ADGRG5 TTC24 SLC32A1 NEK8 SLC23A1 FHIP1A

3.39e-05164165695b800c78871354c859abaa832d778786ef7bcc0
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLTRN PKD1L2 CCR5 PLCB2 IL1RL1 LTB4R

3.63e-0516616568e5a262dc4f04c5fc75b9a7a907832a0d7877df0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GPBAR1 LRRTM3 GDF3 VSIR P2RX1 PLCB2

4.01e-051691656b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 MMS22L ANKRD20A2P FANCD2 DDIAS CENPI

4.01e-051691656e7514956b2e4298222ec443f98b2f5289451786e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GPBAR1 LRRTM3 GDF3 VSIR P2RX1 PLCB2

4.01e-0516916562322f03a115c662f808ebfc892192b7d38d48181
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRAF6 ZNF804A SLC32A1 PTPRZ1 SLC18A3 GLRA2

4.15e-05170165614aa86a4f526ed6986afcb28c49225522055550c
ToppCelldroplet-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK1 TBC1D24 FANCD2 P2RX1 C3 LTB4R

4.15e-051701656dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRB10 ZNF804A SLC32A1 PTPRZ1 SLC18A3 GLRA2

4.28e-0517116565efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO10 FANCD2 SLC32A1 DDIAS C3 STAG3

4.28e-051711656913bae728b5e653771a27c79a309eb023699f1d0
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO10 FANCD2 SLC32A1 DDIAS C3 STAG3

4.28e-051711656f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCellwk_15-18-Hematologic-Myeloid-Mast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

F2RL3 STAT5A P2RX1 IL1RL1 ZDHHC19 PTGDR2

4.43e-051721656a7146c255031207e64682ef767884b11c96e0d59
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NFKBIZ ZNF804A SLC32A1 PTPRZ1 SLC18A3 GLRA2

4.72e-051741656a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIR TBC1D24 P2RX1 SLC18A3 CCR5 PLCB2

4.72e-0517416568d6df5938cef542f23259ce471eea1a1afbed03c
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIR TBC1D24 P2RX1 SLC18A3 CCR5 PLCB2

4.72e-0517416562af54c3427aacfa232e2aca6003b4a8ecb8bba66
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIR TBC1D24 P2RX1 SLC18A3 CCR5 PLCB2

4.72e-051741656eca643b8f5b92aeed5a77c94b4301fd8100f9401
ToppCellCOVID-19_Mild-Neu_3|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

TTC39B NBEAL1 GON4L KLHL9 XRN1 DMAC2L

5.03e-0517616562049767fd591045cfcf5b1071d80798e52843f27
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRB10 ZNF804A SLC32A1 PTPRZ1 SLC18A3 GLRA2

5.03e-05176165605ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NBEAL1 TMEM87A XRN1 DIAPH2 STAG2 ZC3HAV1

5.36e-05178165601dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellfacs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTERF3 URB2 ST7L KCNG1 GEMIN4 GPC2

5.70e-0518016567368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCellfacs-GAT-Fat-3m-Lymphocytic-T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG5 MEI1 LCP1 IL1RL1 LTB4R ZC3HAV1

6.06e-051821656751bd3e3b49de961523e98197688a05c998c121a
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 DDX60 PTPRZ1 DNAH11

6.06e-051821656a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCellwk_08-11-Hematologic-Myeloid-pre-pDC/DC5|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ADGRG5 TTC24 CCDC168 LCP1 VSIR P2RX1

6.06e-051821656fec8a2d6d4099722b8e1bb41222108ed74268fcf
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 DDX60 PTPRZ1 DNAH11

6.06e-051821656831b5ce46b41efe01c4db6016c2f43148611373d
ToppCellwk_15-18-Hematologic-Myeloid-MEP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ZNF804A STAT5A TFRC P2RX1 IL1RL1 SLC29A1

6.44e-05184165619d61d0ab038b7e729e13a46f88b8cf31759485d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 APOB PKD1L2 UNC79 HYDIN DNAH11

6.44e-0518416562cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 APOB PKD1L2 UNC79 HYDIN DNAH11

6.44e-051841656ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 APOB PKD1L2 UNC79 HYDIN DNAH11

6.44e-0518416562b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 DDX60 PTPRZ1 DNAH11

6.63e-051851656efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 PTPRZ1 GPC2 DNAH11

6.63e-0518516562e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DYNC2H1 DNAH7 GAS2L2 CFAP206 HYDIN DNAH11

6.63e-0518516565e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 PTPRZ1 GPC2 DNAH11

6.63e-0518516567aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 MROH9 ZBTB20 DDX60 PTPRZ1 DNAH11

6.63e-051851656fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCellHSPCs-Eo/Baso_prog.|World / Lineage and Cell class

NFKBIZ LCP1 P2RX1 P2RX4 PLCB2 LTB4R

6.63e-051851656b40ea11f5e536438b400ca5fddfd4559789036bd
ToppCelltumor_Lung-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

ADGRG5 TTC24 SLC32A1 P2RX1 NEK8 FHIP1A

6.83e-0518616563d7c1a281fb82db4471283f39937007d889a5f38
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMPRSS9 ITSN1 GRB10 CAV2 TFRC ABCC2

6.83e-051861656f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TMPRSS9 ITSN1 GRB10 CAV2 TFRC ABCC2

6.83e-0518616568694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ADRA2B ANKRD20A4P ANKRD20A1

6.83e-051861656b05c394aa3573ba855abc3066739ca193883b0c3
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DOCK1 TTC39B ITSN1 GRB10 UNC79 HYDIN

7.25e-051881656b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellwk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILC2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ADGRG5 MEI1 LCP1 CCR5 IL1RL1 PTGDR2

7.46e-0518916569c963f525ae765499b3e3229fead3aef018345ef
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

DDX60 CLTRN NFKBIZ XRN1 PARP9 ZC3HAV1

7.91e-0519116562da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

MMS22L TMEM161B TFRC UBE4A URB1 NUP155

7.91e-0519116569454f642c3621370fa23640b631301346b300950
ToppCellPCW_10-12-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADGRG5 LCP1 ZNF804A P2RX1 IL1RL1 PTGDR2

7.91e-05191165647f20686001f945bc31d5a0b974958e4009edb34
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

MROH9 DYNC2H1 DNAH7 CFAP206 HYDIN DNAH11

8.37e-051931656ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellcontrol-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

DDX60 XRN1 CDK5RAP2 PARP9 ZDHHC19 ZC3HAV1

8.62e-051941656267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 DNAH7 CNTN5 CFAP206 HYDIN DNAH11

8.86e-0519516560fbba312e9ba9b70b4b814b67b6eb1f6544aaf6d
ToppCellFetal_29-31_weeks-Immune-monocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GPBAR1 LCP1 ZNF804A VSIR P2RX1 PLCB2

9.37e-0519716568b9a88fb671d5c2b25d291c851e2b8a478f2610c
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MROH9 DNAH7 CNTN5 CFAP206 HYDIN DNAH11

9.37e-0519716566e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

LRRC59 FANCD2 DDIAS CSE1L MTFR1 CENPI

9.64e-051981656880f9817f5145f10f29fc05c5866090433532fe2
ToppCelldistal-Epithelial-Ciliated-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MROH9 DNAH7 GAS2L2 CFAP206 HYDIN DNAH11

9.64e-051981656d30d6c6a0a78b7571318b5b2a0186df96dd0f5a9
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DNAH7 PTPRZ1 CFAP206 C3 HSD17B2 HYDIN

9.91e-05199165660919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DNAH7 PTPRZ1 CFAP206 C3 HSD17B2 HYDIN

9.91e-0519916566aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

TMEM144 DDX60 LCP1 VSIR P2RX4 C3

1.02e-0420016560eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DNAH7 CRHBP PTPRZ1 CFAP206 HSD17B2 HYDIN

1.02e-042001656cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-BMP_responsible_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

GPBAR1 TMEM144 LCP1 VSIR P2RX4 C3

1.02e-042001656cd0d69f973ca3204b500d12031b403a1f4593431
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

PI4K2B CAV2 MEI1 STAT5A QPRT LTB4R

1.02e-042001656aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

TMEM144 NFKBIZ LCP1 VSIR C3 PLCB2

1.02e-042001656fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DNAH7 CRHBP PTPRZ1 CFAP206 HSD17B2 HYDIN

1.02e-042001656a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADGRG5 RNPEPL1 VSIR P2RX4 C3 PLCB2

1.02e-04200165680e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

PI4K2B CAV2 MEI1 STAT5A QPRT LTB4R

1.02e-042001656a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

ZBTB20 RNPEPL1 ASAP3 STAT5B PPP6R3

1.07e-04126165544b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Vip_(ventral_GP_(vGP))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GPR63 CCDC168 HSD17B2 PTGDR2

1.18e-04681654ad6c363d7fb3c436e894db30a544748c5df75a45
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Vip_(ventral_GP_(vGP))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GPR63 CCDC168 HSD17B2 PTGDR2

1.18e-0468165482d928f5eefa065d26096a84b0d78f131dcc8c73
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Vip_(ventral_GP_(vGP))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GPR63 CCDC168 HSD17B2 PTGDR2

1.18e-04681654d97199a8c6afa79bff1600f00c2dbf6286df24a2
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-pDC|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGRG5 TTC24 DSC3 MEI1 ZDHHC19

1.19e-041291655454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|367C / Donor, Lineage, Cell class and subclass (all cells)

ADGRG5 URB2 TRRAP FBXO46 SCAI

1.28e-041311655cc5b5afab8622e98f673fa116a226d930c295327
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTC24 C3 SLC23A1 PTGDR2

1.32e-04701654986c7a1002a4ffd3a246495bedde2997ffdc2c9d
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTC24 C3 SLC23A1 PTGDR2

1.32e-04701654c0330216305491d7d57cdbea0ae3cb8e9092c8e3
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P3|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTC24 C3 SLC23A1 PTGDR2

1.32e-0470165486dde790fcdaec2095e2256463953077811145d2
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTC24 C3 SLC23A1 PTGDR2

1.32e-04701654e604660b2efbc03e21806dcaecf7a72321673ae2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Mme_Fam114a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

APOB CRHBP SLC32A1 AGTR2 HSD17B2

1.37e-041331655fc319644868078ea0f88a71d55f5e858c6848b50
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TMPRSS9 F2RL3 APOB ZDHHC19

1.56e-0473165451bcbb57ee6c45cad88cb3e2cedab2cf3503b2a5
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZBTB20 ZNF804A PTPRZ1 SLC18A3 GLRA2

1.58e-041371655d346086f42d8f04d3fa67fe696834284acdc7080
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADGRG5 APOB ADRA2B GPAT2

1.64e-04741654ef4c9eafc794c7d50aef28b37d21b52d3c511499
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADGRG5 APOB ADRA2B GPAT2

1.64e-047416546ecbdf4186039a031410e09ecd5afa66b6d5e2dc
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TMPRSS9 MEI1 ADRA2B GPAT2

1.92e-0477165410969743351c49a1d6d8ae1ef93098e7786ca3fe
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CAV2 ZNF804A PTPRZ1 SLC18A3 GLRA2

1.99e-0414416557de962346ba9653d90dd13bb7d977fe44d200bba
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP1 VSIR SLC32A1 LTB4R HSD17B2

2.06e-04145165588e463d5396a8fea2b7b1ecf3c9b144e16b35234
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP1 VSIR SLC32A1 LTB4R HSD17B2

2.06e-041451655911fee7f27694393e348d94470a1a4e890038902
ComputationalGenes in the cancer module 267.

CHRNE P2RX1 P2RX4 GLRA2

1.08e-05151054MODULE_267
DrugICI 182,780; Down 200; 1uM; ssMCF7; HG-U133A

ITSN1 GART ASAP3 GRB10 URB2 PSME4 GEMIN4 LRP6 PSME3 KLHDC10

1.48e-0619616210523_DN
DrugEstropipate [7280-37-7]; Up 200; 9.2uM; MCF7; HT_HG-U133A

DOCK3 PPFIA1 ST7L CHRNE URB1 P2RX1 KCNG1 SV2A LTB4R PTGDR2

1.55e-06197162106068_UP
DrugIsoxicam [34552-84-6]; Down 200; 12uM; MCF7; HT_HG-U133A

TRAF6 DYNC2H1 ITSN1 STAT5B PRKACA IRAK4 KLHDC10 DMAC2L SLC29A1 PPP6R3

1.62e-06198162107028_DN
DrugMenadione [58-27-5]; Down 200; 23.2uM; HL60; HT_HG-U133A

CLGN DYNC2H1 DDX60 ITSN1 LGR4 MTFR1 CENPI LRP6 PSME3

1.22e-0519716292439_DN
Drugvinblastine sulfate; Down 200; 0.1uM; PC3; HT_HG-U133A

DNAJC13 PPFIA1 ITSN1 CSE1L SYNJ1 KCNG1 CENPI IRAK4 CDK5RAP2

1.27e-0519816297556_DN
DrugCefoperazone dihydrate; Down 200; 5.8uM; HL60; HG-U133A

EMC1 UGGT1 GART BCCIP TMEM168 QPRT GEMIN4 PSME3 SLC29A1

1.33e-0519916291627_DN
Diseasemean corpuscular hemoglobin concentration

ADGRG5 DNAJC13 RNPEPL1 ITSN1 BCCIP GON4L URB2 LCP1 TFRC CNTN5 KCNJ12 PARP9 ZDHHC19 SLC23A1 SLC29A1 VPS13B PPP6R3

8.81e-05110515717EFO_0004528
Diseaseadipose tissue measurement

DOCK1 MMS22L KLHL9 CNTN5

9.70e-05451574EFO_0004764
Diseaseautosomal recessive polycystic kidney disease (is_marker_for)

GPBAR1 C3

1.68e-0441572DOID:0110861 (is_marker_for)
Diseasecoronary artery disease, plasminogen activator inhibitor 1 measurement

NBEAL1 DYNC2H1 APOB LCP1

3.60e-04631574EFO_0001645, EFO_0004792
DiseaseCarcinoma, Lobular

STAT5A AGTR2

4.16e-0461572C0206692
Diseasegastric adenocarcinoma (is_marker_for)

STAT5A STAT5B PTPRZ1

4.39e-04281573DOID:3717 (is_marker_for)
Diseasetissue plasminogen activator measurement, coronary artery disease

NBEAL1 DYNC2H1 APOB LCP1

5.68e-04711574EFO_0001645, EFO_0004791
DiseaseHelicobacter Infections

TFRC PTPRZ1

5.80e-0471572C0079487
Diseasecholesteryl esters to total lipids in large LDL percentage

TTC39B APOB LCP1

5.95e-04311573EFO_0022249
Diseasetriacylglycerol 54:5 measurement

MMS22L LCP1 KCNJ18

6.54e-04321573EFO_0010423
Diseasepolyunsaturated fatty acid measurement

TTC39B ASAP3 APOB LCP1 DNAH11

6.95e-041311575EFO_0010733
Diseaseanterior uveitis (biomarker_via_orthology)

C3 CCR5

9.88e-0491572DOID:1407 (biomarker_via_orthology)
Diseasekynurenine measurement

GPR63 CNTN5 DNAH11

1.17e-03391573EFO_0008529
Diseasemean reticulocyte volume

ADGRG5 RNPEPL1 ITSN1 GRB10 URB2 LCP1 TRRAP TBC1D24 TFRC CNTN5 SLC29A1 STAG2

1.22e-0379915712EFO_0010701
Diseaselevel of Triacylglycerol (51:3) in blood serum

APOB LCP1

1.23e-03101572OBA_2045163
DiseaseCombined immunodeficiency

STAT5A STAT5B TFRC

1.36e-03411573C0494261
DiseaseColorectal Carcinoma

ABCA4 RNPEPL1 ASAP3 APOB ZNF804A ABCC6 TFRC CSE1L ATAD1 ABCC2 SLC29A1

1.39e-0370215711C0009402
DiseasePARKINSON DISEASE, LATE-ONSET

DNAJC13 ADH1C

1.79e-03121572C3160718
Diseaseintegral membrane protein 2B measurement

APOB LCP1

1.79e-03121572EFO_0802634
Diseaserhinitis (is_marker_for)

C3 IL1RL1 PTGDR2

1.90e-03461573DOID:4483 (is_marker_for)
DiseasePrimary Ciliary Dyskinesia

GAS2L2 HYDIN DNAH11

2.02e-03471573C4551720
Diseasegastroesophageal reflux disease

MMS22L APOB ANO10 UNC79

2.11e-031011574EFO_0003948
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

PTPRZ1 C3

2.11e-03131572DOID:332 (biomarker_via_orthology)
Diseasegallbladder cancer (is_implicated_in)

APOB CCR5

2.11e-03131572DOID:3121 (is_implicated_in)
Diseasebrain ischemia (biomarker_via_orthology)

PRKACA IRAK4 C3 CCR5

2.19e-031021574DOID:2316 (biomarker_via_orthology)
Diseasecholesteryl esters to total lipids in small VLDL percentage

TTC39B APOB LCP1

2.28e-03491573EFO_0022256
Diseaselipoprotein measurement

DOCK1 TTC39B APOB LCP1

2.43e-031051574EFO_0004732
Diseaselow density lipoprotein triglyceride measurement

APOB LCP1

2.82e-03151572EFO_0009946
Diseasetriacylglycerol 52:3 measurement

APOB LCP1

2.82e-03151572EFO_0010415
DiseaseAutosomal recessive primary microcephaly

SASS6 CDK5RAP2

2.82e-03151572cv:C3711387
Diseasecoronary artery disease, factor VII measurement

NBEAL1 DYNC2H1 APOB LCP1

2.97e-031111574EFO_0001645, EFO_0004619
Diseasetriglycerides in very large HDL measurement

TTC39B APOB LCP1

3.17e-03551573EFO_0022324
Diseasefactor VIII measurement, coronary artery disease

NBEAL1 DYNC2H1 APOB LCP1

3.17e-031131574EFO_0001645, EFO_0004630
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

ARL3 NEK8

3.21e-03161572DOID:0110861 (implicated_via_orthology)
Diseasesickle cell anemia (is_implicated_in)

APOB C3

3.21e-03161572DOID:10923 (is_implicated_in)
Diseaseglomerulonephritis (implicated_via_orthology)

AGTR2 C3

3.63e-03171572DOID:2921 (implicated_via_orthology)
Diseasetotal lipids in medium HDL measurement

TTC39B APOB LCP1

3.68e-03581573EFO_0022310
Diseasefree cholesterol in medium HDL measurement

TTC39B APOB LCP1

3.68e-03581573EFO_0022267
Diseasevon Willebrand factor measurement, coronary artery disease

NBEAL1 DYNC2H1 APOB LCP1

3.70e-031181574EFO_0001645, EFO_0004629
Diseaseglycoprotein measurement

ASAP3 APOB LCP1 HYDIN

3.81e-031191574EFO_0004555
Diseasecholesterol in medium HDL measurement

TTC39B APOB LCP1

3.86e-03591573EFO_0021903
Diseasealcohol use disorder (implicated_via_orthology)

CHRNE SLC32A1 PRKACA PRKACG UNC79

3.97e-031951575DOID:1574 (implicated_via_orthology)
Diseasesleep duration, high density lipoprotein cholesterol measurement

TTC39B GRB10 APOB LCP1

4.05e-031211574EFO_0004612, EFO_0005271
Diseasecholesterol to total lipids in medium HDL percentage

TTC39B APOB LCP1

4.05e-03601573EFO_0022237
Diseasefree cholesterol to total lipids in medium HDL percentage

TTC39B APOB LCP1

4.05e-03601573EFO_0022282
DiseaseAge-related macular degeneration

ABCA4 C3

4.07e-03181572cv:C0242383
Diseasevery low density lipoprotein cholesterol measurement, esterified cholesterol measurement

APOB LCP1

4.07e-03181572EFO_0008317, EFO_0008589
Diseaseomega-6 polyunsaturated fatty acid measurement

TTC39B ASAP3 APOB LCP1 DNAH11

4.15e-031971575EFO_0005680
Diseasefree cholesterol in HDL measurement

TTC39B APOB LCP1

4.24e-03611573EFO_0022264
Diseasephospholipids in HDL measurement

TTC39B APOB LCP1

4.24e-03611573EFO_0022293
Diseasefree cholesterol in very large HDL measurement

TTC39B APOB LCP1

4.44e-03621573EFO_0022273
Diseaseangina pectoris

NBEAL1 DYNC2H1 APOB LCP1

4.54e-031251574EFO_0003913
Diseasetotal lipids in HDL measurement

TTC39B APOB LCP1

4.65e-03631573EFO_0022307
Diseasejuvenile dermatomyositis

ADRA2B GPAT2

5.02e-03201572EFO_0000557
DiseaseIgA glomerulonephritis (is_marker_for)

AGTR2 C3

5.02e-03201572DOID:2986 (is_marker_for)
Diseaseplatelet crit

ADGRG5 ZBTB20 RNPEPL1 APOB ST7L CHRNE OR14A2 P2RX1 CNTN5 POLR1B FHIP1A ZC3HAV1

5.06e-0395215712EFO_0007985
Diseasecholine measurement

TTC39B ASAP3 APOB LCP1

5.22e-031301574EFO_0010116
Diseasetotal lipids in very large HDL measurement

TTC39B APOB LCP1

5.29e-03661573EFO_0022312
Diseasephospholipids in very large HDL measurement

TTC39B APOB LCP1

5.29e-03661573EFO_0022298

Protein segments in the cluster

PeptideGeneStartEntry
LKAIPSFLNSFNRLV

URB2

1386

Q14146
ALDKDNNTPLLFAII

ANKRD20A1

161

Q5TYW2
KAAQSLFPFIEKLAA

ASAP3

231

Q8TDY4
ALDKDSNTPLLFAII

ANKRD20A8P

161

Q5CZ79
ANVDFFKLFRVLPTL

ABCA4

246

P78363
KDFLAQIVLPATFVF

ABCA4

1371

P78363
ALDKDNNTPLLFAII

ANKRD20A4P

161

Q4UJ75
FSLDALITNILPFEK

ADH1C

341

P00326
TKALLAFAIPAFVIV

ADGRF4

556

Q8IZF3
IDLALPFAILLGFTN

AGTR2

296

P50052
VLIFANKQDLLTAAP

ARL3

121

P36405
ALLALLQLKDFDFVP

C3

1236

P01024
PTLKDIFLAVENALL

DNAH11

316

Q96DT5
PQNLFLVSLAAADIL

ADRA2B

46

P18089
KAFLEPLSQLQVADF

DNHD1

3226

Q96M86
NLAISDLFFLLTVPF

CCR5

71

P51681
ENPDLFAKLALNFAT

DIAPH2

666

O60879
NLVQAFKTALPSLEL

DMAC2L

196

Q99766
FLFLIAQKIPETSLS

CHRNE

286

Q04844
GAFINLLAPLFNEKA

CDK5RAP2

771

Q96SN8
LFPETTANFDKLLIQ

CFAP206

401

Q8IYR0
AELKILASAPTFALN

CNTN5

471

O94779
TLNLFQHLPELKSFF

NBEAL1

2301

Q6ZS30
PAFLKAAENFTLLVK

P2RX4

176

Q99571
SLSLLFQKVFAQIFP

PARP9

21

Q8IXQ6
DFLLATAAAPKVLAI

OR52Z1P

56

P0C646
ALDKDNNTPLLFAII

ANKRD20A2P

161

Q5SQ80
ALLALKFILAFAIPD

ANO10

601

Q9NW15
KTLLDPFQFVRNSLA

DPY19L2P1

71

Q6NXN4
LQAVNFPFLVKLEFS

PRKACA

96

P17612
LFLELPSCLSFVNAK

NFKBIZ

631

Q9BYH8
DLVENKFLLPSANSF

KCNJ12

361

Q14500
DLLNNKLVTLPVSFA

LRRC59

91

Q96AG4
APNFSFLSLLANLLL

GPBAR1

91

Q8TDU6
LILADKLQGPFSFEL

GPC2

301

Q8N158
VLDLLNFLKPAFVTS

MMS22L

551

Q6ZRQ5
LFLKAPVNTAELTDL

BCCIP

81

Q9P287
NQLERFKLSALAPLF

DDX60

216

Q8IY21
PDLAFSFLLILALGQ

GDF3

6

Q9NR23
SFALALLLPVFLAVA

NAT14

61

Q8WUY8
FNELNDLFKAACLPL

LCP1

31

P13796
LVKIFSFLPTRALAA

FBXO46

481

Q6PJ61
EKLLAAFPNLANLSR

KLHDC10

411

Q6PID8
LPFSESLNKFLAVLE

DDIAS

416

Q8IXT1
LASLKRAFEAANLPA

NEK8

196

Q86SG6
RAFEAANLPALVLKI

NEK8

201

Q86SG6
LEAASFLQILPVLDF

KLHL9

126

Q9P2J3
LKLPFERLAFVLSSN

KLHL9

191

Q9P2J3
KNPASLLFSLFEAIN

LCT

291

P09848
LFFSGLSKPIALALD

LRP6

1096

O75581
ETFDFSALALLLQIP

PPFIA1

1086

Q13136
ALTLALNKISSIPDF

LGR4

181

Q9BXB1
SNLLAQSFILLKPVF

TUBGCP4

566

Q9UGJ1
FLLKLVNDIFTFVSP

ABCC2

326

Q92887
TFVSPQLLKLLISFA

ABCC2

336

Q92887
LEFLLRLIQAPSKFA

KCNG1

281

Q9UIX4
APALDFSLKLFAKEV

QPRT

276

Q15274
FGKQAALDPFILLNL

PTPRZ1

206

P23471
SFVDPLLQFESQLKI

MROH9

51

Q5TGP6
LAVSKFLLAFLVPLA

PTGDR2

206

Q9Y5Y4
PVLFAKAAQIFITEL

NFYC

66

Q13952
ALADLAVLLTAPFFL

LTB4R

61

Q15722
VDLADKLLQVASPFL

NUP155

1046

O75694
LKTKPRFDFANLALA

OSR1

111

Q8TAX0
QPLKVLGFAAFFALV

PKD1L2

1871

Q7Z442
EKLFPLFLSILDGAQ

MEI1

221

Q5TIA1
FLIKIAAIDNGLAFP

PI4K2B

336

Q8TCG2
SAVAFFVPSNLLLLL

F2RL3

291

Q96RI0
DLLFFEKAPSRQISL

MTFR1

106

Q15390
ELATLPKRAQLAAAF

DYNC2H1

3196

Q8NCM8
ALDKDNNTPLLFAII

ANKRD20A3P

161

Q5VUR7
ILKIQSPLFTLDANA

APOB

2761

P04114
AAALFPEFLKELAAL

FHIP1A

1006

Q05DH4
FASGQLLKFLPAAVA

IL1RL1

66

Q01638
ARAILDFPDKLNFST

HYDIN

196

Q4G0P3
LQAIDFPFLVKLQFS

PRKACG

96

P22612
KFAATPSLALFVNLK

DOCK1

216

Q14185
AALLNSFPTIFDELL

DOCK3

786

Q8IZD9
LDFLNNLEPKFITLA

DSC3

876

Q14574
PFLLFSANLKRELAG

CRHBP

36

P24387
ALAFLAEAPAQAQKI

GAS2L2

76

Q8NHY3
FLFNDFLLLTQITKP

ITSN1

1481

Q15811
SILFFSLADLANIEP

DNAH7

3211

Q8WXX0
PLLKAFAQAAAFLRQ

GPAT2

696

Q6NUI2
LKDFAAFLLPEQALA

GON4L

1686

Q3T8J9
TFQLEVPKAFAASLL

DNAJC13

1701

O75165
ISRAAFPLAFLIFNI

GLRA2

421

P23416
TLLPFAEAEAFLKKA

MAP7D1

816

Q3KQU3
LFLLRDSQSNPKAFV

GRB10

516

Q13322
AAFKSLNLPLQITLS

GPR63

71

Q9BZJ6
DLLIQNEFFAPASLL

IRAK4

86

Q9NWZ3
SLLKNFPQTALVSFA

EMC1

311

Q8N766
TIFKNAEFLVLTLNP

CCDC168

416

Q8NDH2
KPLLFDHLAQLFFTS

CENPI

471

Q92674
KFLTVFLAIPLAFIA

CAV2

86

P51636
FLLLINSLASKDFSP

HSD17B2

306

P37059
AHLALLVAKNISFFP

SLC12A6

886

Q9UHW9
LLVDFLAFPQKFIDL

SASS6

76

Q6UVJ0
AINLLPLLFSQDFAK

FANCD2

696

Q9BXW9
KAPFLLNFSVERLDN

MTERF3

246

Q96E29
LKNLSFLDVFLVSVP

OR14A2

61

Q96R54
PALLREAENFTLFIK

P2RX1

176

P51575
KPALSFLFLSNLFLA

PIGB

386

Q92521
DLVENKFLLPSANSF

KCNJ18

361

B7U540
ANLIKELIDDFIFPA

USP9X

1456

Q93008
QDLLDSFLSFFPELK

RNPEPL1

481

Q9HAU8
KRVPFLVLAAVSLFD

SLC18A3

241

Q16572
ALLLLAVAKPFSAAA

SLC18A3

256

Q16572
IAEFKLIPGLNNLFD

TRPC4AP

411

Q8TEL6
VALSSLKNIFTPLLF

TMEM161B

441

Q8NDZ6
KIDPFEDLSFNLLAV

SYNJ1

1321

O43426
QFSKLNLALFPRLVS

LRRTM3

216

Q86VH5
IAVFLSLLPLNFFIS

ABCC6

456

O95255
EAFNLAFAELRKLLP

NHLH2

91

Q02577
NVSFVLVPFKVLDLL

ST3GAL2

211

Q16842
LLINKPDGTFLLRFS

STAT5B

606

P51692
TFLARQLAKPDNTLF

VPS8

836

Q8N3P4
FISEPLFKLSLAKFD

SCGB1D2

36

O95969
NLINPSSLLELFFEL

SDAD1

111

Q9NVU7
KVEKLTLDNAAFPFL

TFRC

531

P02786
LAQLVPFARAKDLSV

URB1

1326

O60287
TAILVKVQLDALPFF

SLC29A1

126

Q99808
TKAAPILFASAALAL

SV2A

711

Q7L0J3
LLINKPDGTFLLRFS

STAT5A

606

P42229
VLLLNIAFLLSPAFA

ADGRG5

291

Q8IZF4
AVFSLAIKLQPSIIF

ATAD1

176

Q8NBU5
AISAVLAKPFIFADK

CLGN

121

O14967
FFLNDQTLEFLKIPS

CLTRN

116

Q9HBJ8
LSFPISKLLDFFLGQ

CNNM4

316

Q6P4Q7
ANFFPKKLLELDSFL

PSME3

31

P61289
KILLCLANQFPDISF

TBC1D24

116

Q9ULP9
VLDAFALPLTNLFKA

CSE1L

176

P55060
IAPFVEILLTNLFKA

CSE1L

546

P55060
FLSNKFTDALELLRP

TTC39B

146

Q5VTQ0
LNNFQRAFLLASKAP

TTC24

56

A2A3L6
FSADAEKVTPLLQLL

STAG3

591

Q9UJ98
PLKFRVLFANLAALF

PXMP2

171

Q9NR77
RFTQPKEAEAFLLSL

REV1

721

Q9UBZ9
LFQASAFAFLVPAKA

SLC23A1

106

Q9UHI7
AFAFLVPAKAILALE

SLC23A1

111

Q9UHI7
PNANLVKTLVFFFLE

STAG2

456

Q8N3U4
FVAILLFGSNFVPLK

TMEM144

16

Q7Z5S9
LLLFVADAAFTEVPK

VSTM2B

21

A6NLU5
AFALAKEKAPSIIFI

PSMC3

271

P17980
QLFPDNFAKREILSL

TRAF6

116

Q9Y4K3
LFLAASLGPVAAFKV

VSIR

21

Q9H7M9
FTAFPNLAKTALEIL

ZBED8

521

Q8IZ13
FEQLLAVLPAASKNL

XRN1

511

Q8IZH2
FDLAVLELASPLAFN

TMPRSS9

591

Q7Z410
AASFKELPANSVLLI

SCAI

351

Q8N9R8
LAAVTVFLNSLTPKF

ST7L

66

Q8TDW4
AIPNLVIFAVLLFFS

TMEM168

201

Q9H0V1
TAVTEQLQLLPLFFK

PSME4

1591

Q14997
DLTVALANPIKFFSA

PLCB2

811

Q00722
FILSADFPALVVKAS

GART

136

P22102
VLAAGSPFFQDKLLL

ZBTB20

121

Q9HC78
SSIVKNLNFIPFDIF

VPS13B

1826

Q7Z7G8
LPSLFAAFNVVLLVF

ZDHHC19

26

Q8WVZ1
FLLHDPSNFLKTALF

TMEM130

161

Q8N3G9
LPFFAAVEVLEKSLF

SLC32A1

396

Q9H598
KEELAVLLLQSDPFF

ZC3HAV1

131

Q7Z2W4
SDAFFLNLGAALLKL

UBE4A

431

Q14139
SILFDPNDAFTLKLE

UGT2B28

61

Q9BY64
FLPLGFALKALVSFS

POLR1B

246

Q9H9Y6
LNPLLASFFSKVLSI

PPP6R3

116

Q5H9R7
PLSDLSLAVQLFAKN

TRRAP

391

Q9Y4A5
GDNLLPFLRKFIASF

ZFC3H1

1686

O60293
LFPLVVDKFLFVDAD

UGGT1

1346

Q9NYU2
QTDLASLAFIPLAFL

TMEM87A

356

Q8NBN3
LLEPFSKLLSFVIQN

UNC79

2216

Q9P2D8
LLLPSFCKFQLQLSS

ZNF804A

306

Q7Z570
KFLAQILTAFPALRF

GEMIN4

576

P57678
PKDVANFFLLLLVLA

TMEM35A

86

Q53FP2