Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	VWFC_1	VWF ZAN CCN2	1.07e-04	36	48	3	PS01208
Domain	VWC	VWF ZAN CCN2	1.26e-04	38	48	3	SM00214
Domain	VWFC_2	VWF ZAN CCN2	1.26e-04	38	48	3	PS50184
Domain	VWF_dom	VWF ZAN CCN2	1.70e-04	42	48	3	IPR001007
Domain	TIL	VWF ZAN	4.20e-04	12	48	2	PF01826
Domain	C8	VWF ZAN	4.20e-04	12	48	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF ZAN	4.95e-04	13	48	2	IPR014853
Domain	C8	VWF ZAN	4.95e-04	13	48	2	SM00832
Domain	TIL_dom	VWF ZAN	5.77e-04	14	48	2	IPR002919
Domain	Growth_fac_rcpt_	ELAPOR2 COMP CCN2 GPR179	6.85e-04	156	48	4	IPR009030
Domain	VWD	VWF ZAN	7.58e-04	16	48	2	SM00216
Domain	VWF_type-D	VWF ZAN	7.58e-04	16	48	2	IPR001846
Domain	VWFD	VWF ZAN	7.58e-04	16	48	2	PS51233
Domain	VWD	VWF ZAN	7.58e-04	16	48	2	PF00094
Domain	CTCK_1	VWF CCN2	9.64e-04	18	48	2	PS01185
Domain	VWC_out	VWF ZAN	1.08e-03	19	48	2	SM00215
Domain	GPCR_3	GPRC5A GPR179	1.32e-03	21	48	2	IPR000337
Domain	7tm_3	GPRC5A GPR179	1.45e-03	22	48	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GPRC5A GPR179	1.45e-03	22	48	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GPRC5A GPR179	1.45e-03	22	48	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GPRC5A GPR179	1.45e-03	22	48	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GPRC5A GPR179	1.45e-03	22	48	2	PS50259
Domain	CT	VWF CCN2	1.45e-03	22	48	2	SM00041
Domain	GPCR_3_C	GPRC5A GPR179	1.45e-03	22	48	2	IPR017978
Domain	Cys_knot_C	VWF CCN2	1.87e-03	25	48	2	IPR006207
Domain	CTCK_2	VWF CCN2	1.87e-03	25	48	2	PS01225
Domain	VWC	VWF CCN2	2.34e-03	28	48	2	PF00093
Domain	EGF	ZAN COMP ITGB8 GPR179	3.08e-03	235	48	4	SM00181
Domain	UBA	DHX57 SNRK	5.71e-03	44	48	2	IPR015940
Domain	UBA	DHX57 SNRK	6.49e-03	47	48	2	PS50030
Domain	DnaJ	DNAJB12 DNAJC13	6.77e-03	48	48	2	PF00226
Domain	DNAJ_1	DNAJB12 DNAJC13	7.04e-03	49	48	2	PS00636
Domain	DNAJ_2	DNAJB12 DNAJC13	7.04e-03	49	48	2	PS50076
Domain	DnaJ	DNAJB12 DNAJC13	7.04e-03	49	48	2	SM00271
Domain	-	DNAJB12 DNAJC13	7.04e-03	49	48	2	1.10.287.110
Domain	DnaJ_domain	DNAJB12 DNAJC13	7.61e-03	51	48	2	IPR001623
Pubmed	Deletion of connective tissue growth factor ameliorates peritoneal fibrosis by inhibiting angiogenesis and inflammation.	CCN2 CNN2	6.57e-06	3	52	2	29165602
Pubmed	CTGF Mediates Tumor-Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression.	CCN2 CNN2	6.57e-06	3	52	2	29967264
Pubmed	Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis.	CCN2 CNN2	6.57e-06	3	52	2	28191821
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	DNAJC13 ZMYM2 TAF1L CNN2 PRRC2B	1.34e-05	203	52	5	22083510
Pubmed	Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.	ADAMTS19 TAF4B	3.28e-05	6	52	2	19508998
Pubmed	Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.	TAF4B TAF1L	3.28e-05	6	52	2	19959467
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NEK1 DNAJC13 CCDC88A KIF15 ZFHX4 ZMYM2	3.71e-05	418	52	6	34709266
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	DNAJC13 CCDC88A SCYL3 GPRC5A CNN2	1.52e-04	339	52	5	37232246
Pubmed	Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.	TAF4B TAF1L	1.69e-04	13	52	2	11557891
Pubmed	Gpr158 mediates osteocalcin's regulation of cognition.	GPRC5A GPR179	1.97e-04	14	52	2	28851741
Pubmed	Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.	VWF CCN2	1.97e-04	14	52	2	36347239
Pubmed	Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs.	VWF CCN2	2.27e-04	15	52	2	28684544
Pubmed	ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death.	CCN2 ITGB8	2.94e-04	17	52	2	38816193
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNAJC13 CCDC88A AKAP9 KIF15 ZMYM2 AFF4 PRRC2B	5.52e-04	963	52	7	28671696
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ELAPOR2 NEK1 AKAP9 TAF4B TAF1L PRRC2B	5.55e-04	689	52	6	36543142
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	CCDC88A SPATA31E1 NCOA4 AFF4 PRRC2B	5.59e-04	450	52	5	16751776
Pubmed	β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin.	CCDC88A GPRC5A	5.93e-04	24	52	2	29635000
Pubmed	The LIFEdb database in 2006.	MKKS SCYL3 ZMYM2 IQCN NCOA4 TKTL2	6.99e-04	720	52	6	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	MKKS SCYL3 ZMYM2 IQCN NCOA4 TKTL2	7.09e-04	722	52	6	15489336
Pubmed	Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.	ZFHX4 ZMYM2	8.08e-04	28	52	2	29365100
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	MKKS ZMYM2 IQCN NCOA4 TKTL2 RIC1	8.63e-04	750	52	6	11230166
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	DNAJC13 MTMR2 DHX57 TAF4B AFF4	8.65e-04	496	52	5	31343991
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DNAJC13 CCDC88A AKAP9 KIF15 SCYL3 MTMR2 PRRC2B	9.12e-04	1049	52	7	27880917
Pubmed	Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.	MKKS ZMYM2 IQCN NCOA4 TKTL2	1.10e-03	523	52	5	11256614
Pubmed	DNA cloning using in vitro site-specific recombination.	MKKS SCYL3 ZMYM2 IQCN NCOA4 TKTL2	1.16e-03	794	52	6	11076863
Interaction	PHF21A interactions	NEK1 DNAJC13 CCDC88A KIF15 ZFHX4 BANP ZMYM2	1.81e-05	343	49	7	int:PHF21A
Interaction	SLC19A4P interactions	BANP ZMYM2	3.46e-05	4	49	2	int:SLC19A4P
Cytoband	17q25	JMJD6 CARD14	9.08e-04	39	52	2	17q25
Cytoband	19p13.1	COMP IQCN	1.37e-03	48	52	2	19p13.1
GeneFamily	G protein-coupled receptors, Class C orphans	GPRC5A GPR179	4.49e-05	7	27	2	285
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB12 DNAJC13	2.42e-03	49	27	2	584
Coexpression	VERNELL_RETINOBLASTOMA_PATHWAY_DN	CCN2 GPRC5A ITGB8	1.06e-05	23	49	3	M12456
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAJC13 CCDC88A ZAN KIF15 KLHDC4	1.68e-06	171	52	5	845f312f8cbe29d820da25f0e6d75deb382bbfd8
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment	IQCN RFX7 ITGB8	7.16e-04	105	49	3	EFO_0007788, EFO_0008007, EFO_0008343

Protein segments in the cluster

Peptide	Gene	Start	Entry
MVAGSPLGATQTCNK	BANP	96	Q8N9N5
SEVNGCSFVMRTGKP	AKAP9	116	Q99996
ACGMQQSVRTGLPSV	COMP	71	P49747
QDCDKTMPRSTPGSN	AFF4	396	Q9UHB7
MATTVPDGCRNGLKS	GPRC5A	1	Q8NFJ5
GMTNGRKAINLCTVP	RIC1	171	Q4ADV7
TPCSRTCGKGMQSRQ	ADAMTS19	986	Q8TE59
TCGRTQPTRVVQGMG	IQCN	1071	Q9H0B3
KMTGTQPIGSLGSIC	MKKS	326	Q9NPJ1
KRRTCSMVGNGDTTS	JMJD6	376	Q6NYC1
MAPGCKTELRSVTNG	KIF15	1	Q9NS87
TGGSPSKQQMRSVIS	NEK1	661	Q96PY6
QMSGSVGSKAADICP	GPR179	1676	Q6PRD1
AQSPCGSPGMKRTES	CCDC88A	231	Q3V6T2
GAMGVDSRTSCSPQK	MICALL2	261	Q8IY33
ITRCSQPMVGVSGKR	MTMR2	281	Q13614
MKNAQERPGLGSTSC	GOLGA6L7	591	A0A1B0GV03
QGRKSAACGQPRMSS	PRSS33	21	Q8NF86
KMRCNPTKSGAGVIS	ELAPOR2	836	A8MWY0
GGMETVCKVSQATPE	SCYL3	141	Q8IZE3
KRGCISMPEQKSASG	NCOA4	181	Q13772
SGDKVRMDPPCTNTT	CTSA	321	P10619
SRKPGMEGCRNVTSN	ITGB8	411	P26012
DMTQQCTVTRKPSSG	CARD14	751	Q9BXL6
KTCGMGISTRVTNDN	CCN2	211	P29279
LEISMQTPGGSSCRK	LINC02908	51	Q6ZV77
GSMCSSLEKQGIPSQ	CPHXL2	166	A0A1W2PPK0
SGMTGCGKTTQIPQF	DHX57	566	Q6P158
QKMGTPSCSRLSEVQ	DNAJB12	356	Q9NXW2
TRASKPSDMSVQVCG	DNAJC13	1461	O75165
RSGCQMSVTPQGGIV	KLHDC4	231	Q8TBB5
GSGMKLNNSCTPITT	MKNK1	236	Q9BUB5
KLACSGSQSPEMGQN	TAF4B	271	Q92750
STATPEKQMCQGQGR	TAF1L	1696	Q8IZX4
VSGKNMTASQGPCAL	SPATA31E1	1156	Q6ZUB1
GQQPGTCMGSKRSQV	MUTYH	496	Q9UIF7
KMCISSTGNAGQVPA	SNRK	686	Q9NRH2
GTNKCASQVGMTAPG	CNN2	211	Q99439
SGSSKRQQGEVCMTV	C10orf90	421	Q96M02
VRMTTATCKPGGEAS	SHANK2-AS3	101	Q9BTD1
MINQGGTEGTKPECT	ZFHX4	2951	Q86UP3
NGRMGTEKQSPSGET	ZNF2	131	Q9BSG1
PSSSCNISSGEMQKG	VWF	206	P04275
ANTKGMCFIRTSQPE	TKTL2	466	Q9H0I9
MCSPKSSENQGTVER	PRRC2B	286	Q5JSZ5
QKEGSECPQGMTSQG	TEX13C	316	A0A0J9YWL9
KSRCNEMLPGTSTGN	RFX7	506	Q2KHR2
MNVPSLRSGSGCQVS	nan	356	Q3C1V9
LCVNQTSGGMKPSSV	TXNDC11	471	Q6PKC3
QGCQTSRTKMTGSAP	ZMYM2	821	Q9UBW7
PTEMKQSGLGSQCTG	PPIP5K1	1011	Q6PFW1
RGSKCGETTSQMPNV	ZNF14	76	P17017
LVGGKPSSCQENSMA	ZAN	1721	Q9Y493