Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-dependent protein kinase activity	PRKDC ATM	8.19e-05	3	105	2	GO:0004677
GeneOntologyMolecularFunction	histone H2AXS139 kinase activity	PRKDC ATM	8.19e-05	3	105	2	GO:0035979
GeneOntologyMolecularFunction	histone H2AX kinase activity	PRKDC ATM	2.71e-04	5	105	2	GO:0141003
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	MICAL1 NOX4	2.71e-04	5	105	2	GO:0106294
GeneOntologyMolecularFunction	2'-5'-oligoadenylate synthetase activity	OAS3 OASL	2.71e-04	5	105	2	GO:0001730
GeneOntologyMolecularFunction	H3K27me3 modified histone binding	TAF1 TAF1L	2.71e-04	5	105	2	GO:0061628
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EPHB3 PIGN ILK DDR2 SCYL1 OAS3 TERT PIK3CB OASL DGKI PRKDC TAF1 ATM TAF1L	3.96e-04	938	105	14	GO:0016772
Domain	G-protein_beta_WD-40_rep	WDR88 COPB2 WDR38 POC1B PWP2 CORO7	6.29e-06	85	100	6	IPR020472
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	2.84e-05	2	100	2	IPR022591
Domain	TBP-binding	TAF1 TAF1L	2.84e-05	2	100	2	PF09247
Domain	DUF3591	TAF1 TAF1L	2.84e-05	2	100	2	PF12157
Domain	TAF_II_230-bd	TAF1 TAF1L	2.84e-05	2	100	2	IPR009067
Domain	-	TAF1 TAF1L	2.84e-05	2	100	2	1.10.1100.10
Domain	TAF1_animal	TAF1 TAF1L	2.84e-05	2	100	2	IPR011177
Domain	PI3/4_kinase_CS	PIK3CB PRKDC ATM	6.47e-05	15	100	3	IPR018936
Domain	-	PIK3CB PRKDC ATM	7.93e-05	16	100	3	1.10.1070.11
Domain	PI3Kc	PIK3CB PRKDC ATM	7.93e-05	16	100	3	SM00146
Domain	PI3_PI4_kinase	PIK3CB PRKDC ATM	1.15e-04	18	100	3	PF00454
Domain	PI3_4_KINASE_1	PIK3CB PRKDC ATM	1.15e-04	18	100	3	PS00915
Domain	PI3_4_KINASE_2	PIK3CB PRKDC ATM	1.15e-04	18	100	3	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3CB PRKDC ATM	1.15e-04	18	100	3	IPR000403
Domain	PI3_4_KINASE_3	PIK3CB PRKDC ATM	1.15e-04	18	100	3	PS50290
Domain	OAS1_C	OAS3 OASL	1.69e-04	4	100	2	PF10421
Domain	2-5-oligoadenylate_synth_CS	OAS3 OASL	1.69e-04	4	100	2	IPR006117
Domain	25A_SYNTH_3	OAS3 OASL	1.69e-04	4	100	2	PS50152
Domain	2-5-oligoAdlate_synth_1_dom2/C	OAS3 OASL	1.69e-04	4	100	2	IPR018952
Domain	2-5A_synthase	OAS3 OASL	1.69e-04	4	100	2	IPR026774
Domain	-	OAS3 OASL	1.69e-04	4	100	2	1.10.1410.20
Domain	25A_SYNTH_1	OAS3 OASL	1.69e-04	4	100	2	PS00832
Domain	25A_SYNTH_2	OAS3 OASL	1.69e-04	4	100	2	PS00833
Domain	WD40_repeat_dom	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 VPS41 CORO7	1.95e-04	297	100	8	IPR017986
Domain	WD40_repeat_CS	WDR36 WDR88 WDR38 POC1B PWP2 CORO7	2.52e-04	164	100	6	IPR019775
Domain	2-5-oligoadenylate_synth_N	OAS3 OASL	2.81e-04	5	100	2	IPR006116
Domain	FATC	PRKDC ATM	2.81e-04	5	100	2	PF02260
Domain	Bromodomain_CS	BPTF TAF1 TAF1L	3.54e-04	26	100	3	IPR018359
Domain	FAD-bd	MICAL1 MICAL3	4.20e-04	6	100	2	IPR002938
Domain	FAD_binding_3	MICAL1 MICAL3	4.20e-04	6	100	2	PF01494
Domain	FAT	PRKDC ATM	4.20e-04	6	100	2	PS51189
Domain	FATC	PRKDC ATM	4.20e-04	6	100	2	PS51190
Domain	FAT	PRKDC ATM	4.20e-04	6	100	2	PF02259
Domain	PIK-rel_kinase_FAT	PRKDC ATM	4.20e-04	6	100	2	IPR003151
Domain	FATC_dom	PRKDC ATM	4.20e-04	6	100	2	IPR003152
Domain	PIK_FAT	PRKDC ATM	4.20e-04	6	100	2	IPR014009
Domain	FATC	PRKDC ATM	4.20e-04	6	100	2	SM01343
Domain	WD40/YVTN_repeat-like_dom	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 VPS41 CORO7	4.38e-04	335	100	8	IPR015943
Domain	WD40	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	4.86e-04	259	100	7	PF00400
Domain	DUF3585	MICAL1 MICAL3	5.86e-04	7	100	2	IPR022735
Domain	DUF3585	MICAL1 MICAL3	5.86e-04	7	100	2	PF12130
Domain	WD40	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	5.96e-04	268	100	7	SM00320
Domain	WD40_repeat	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	6.50e-04	272	100	7	IPR001680
Domain	WD_REPEATS_1	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	7.39e-04	278	100	7	PS00678
Domain	WD_REPEATS_2	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	7.55e-04	279	100	7	PS50082
Domain	WD_REPEATS_REGION	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	7.55e-04	279	100	7	PS50294
Domain	BROMODOMAIN_1	BPTF TAF1 TAF1L	1.01e-03	37	100	3	PS00633
Domain	Bromodomain	BPTF TAF1 TAF1L	1.10e-03	38	100	3	PF00439
Domain	BROMODOMAIN_2	BPTF TAF1 TAF1L	1.37e-03	41	100	3	PS50014
Domain	Bromodomain	BPTF TAF1 TAF1L	1.47e-03	42	100	3	IPR001487
Domain	BROMO	BPTF TAF1 TAF1L	1.47e-03	42	100	3	SM00297
Domain	-	BPTF TAF1 TAF1L	1.47e-03	42	100	3	1.20.920.10
Domain	-	WDR36 WDR88 COPB2 WDR38 POC1B VPS41 CORO7	2.09e-03	333	100	7	2.130.10.10
Domain	Quinoprotein_ADH-like_supfam	WDR36 WDR88 PWP2	2.87e-03	53	100	3	IPR011047
Domain	FN3	EPHB3 FLRT3 FLRT1 SDK1 IL9R	4.34e-03	199	100	5	PS50853
Domain	FN3_dom	EPHB3 FLRT3 FLRT1 SDK1 IL9R	5.33e-03	209	100	5	IPR003961
Pathway	REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING	TRPC4 PITPNA PLCG1	1.69e-05	10	75	3	M27330
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ERCC3 WDR36 COPB2 INTS10 BPTF FASN PWP2 DYNC1LI1 TAF1 ATM TAF1L	2.84e-08	370	110	11	22922362
Pubmed	HIV-host interactome revealed directly from infected cells.	COPB2 GPX7 FASN ERAP2 OSBPL8 ITPRIP TMX3 IL9R	8.11e-08	172	110	8	27375898
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	ILK NUP107 COPB2 BPTF FASN MDN1 ANLN PRKDC TAF1	1.18e-06	332	110	9	32786267
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	AMPD2 NUP107 SCYL1 BPTF ANLN DYNC1LI1 MICAL3 PRKDC CORO7	2.29e-06	360	110	9	33111431
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ILK NUP107 COPB2 MAGEE2 FASN MDN1 ANLN DYNC1LI1 PRKDC ATM NUDC	2.51e-06	582	110	11	20467437
Pubmed	Defining the membrane proteome of NK cells.	PIGN ILK NUP107 ELOVL5 SCYL1 ASPHD2 FASN MDN1 DNAJC14 OASL OSBPL8 DYNC1LI1 ITPRIP PRKDC CORO7	4.25e-06	1168	110	15	19946888
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	WDR36 NUP107 COPB2 BPTF FASN MDN1 PWP2 OASL OSBPL8 PRKDC ATM	7.46e-06	653	110	11	22586326
Pubmed	Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.	TERT ATM	9.91e-06	2	110	2	22341440
Pubmed	Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.	PRKDC ATM	9.91e-06	2	110	2	11231155
Pubmed	Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.	PRKDC ATM	9.91e-06	2	110	2	10464290
Pubmed	Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.	PRKDC ATM	9.91e-06	2	110	2	27939942
Pubmed	Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism.	TERT ATM	9.91e-06	2	110	2	21297001
Pubmed	The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.	PRKDC ATM	9.91e-06	2	110	2	21487018
Pubmed	Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.	PRKDC ATM	9.91e-06	2	110	2	26057167
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	9.91e-06	2	110	2	38804708
Pubmed	DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.	PRKDC ATM	9.91e-06	2	110	2	19071136
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	9.91e-06	2	110	2	22842574
Pubmed	Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.	PRKDC ATM	9.91e-06	2	110	2	12065055
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	9.91e-06	2	110	2	27571988
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	9.91e-06	2	110	2	34403156
Pubmed	Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.	PRKDC ATM	9.91e-06	2	110	2	17189255
Pubmed	AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.	PRKDC ATM	9.91e-06	2	110	2	22972376
Pubmed	G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation.	PRKDC ATM	9.91e-06	2	110	2	26774662
Pubmed	DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism.	PRKDC ATM	9.91e-06	2	110	2	36727301
Pubmed	Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks.	PRKDC ATM	9.91e-06	2	110	2	32674014
Pubmed	BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.	BPTF PRKDC	9.91e-06	2	110	2	28579392
Pubmed	Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.	TERT ATM	9.91e-06	2	110	2	14570874
Pubmed	Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.	PRKDC ATM	9.91e-06	2	110	2	21245310
Pubmed	The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.	PRKDC ATM	9.91e-06	2	110	2	17593081
Pubmed	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.	TAF1 TAF1L	9.91e-06	2	110	2	10070062
Pubmed	NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.	NOX4 ATM	9.91e-06	2	110	2	25646414
Pubmed	BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.	TERT BPTF	9.91e-06	2	110	2	30419422
Pubmed	Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.	PRKDC ATM	9.91e-06	2	110	2	20617180
Pubmed	DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.	PRKDC ATM	9.91e-06	2	110	2	18172300
Pubmed	Identification of potential protein interactors of Lrrk2.	AGO1 MDN1 PRKDC	1.36e-05	15	110	3	17400507
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	NUP107 FASN MDN1 GPR142 PWP2 OSBPL8 PRKDC	2.65e-05	272	110	7	31010829
Pubmed	Semi-automatic classification of skeletal morphology in genetically altered mice using flat-panel volume computed tomography.	DDR2 PRKDC	2.97e-05	3	110	2	17658952
Pubmed	Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.	TERT DYNC1LI1	2.97e-05	3	110	2	32513296
Pubmed	Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.	PRKDC ATM	2.97e-05	3	110	2	9766667
Pubmed	Identification and characterization of FUS/TLS as a new target of ATM.	PRKDC ATM	2.97e-05	3	110	2	18620545
Pubmed	Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.	PRKDC ATM	2.97e-05	3	110	2	30224064
Pubmed	DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.	PRKDC ATM	2.97e-05	3	110	2	18644470
Pubmed	Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.	PRKDC ATM	2.97e-05	3	110	2	18451257
Pubmed	Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.	PRKDC ATM	2.97e-05	3	110	2	23836881
Pubmed	DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.	PRKDC ATM	2.97e-05	3	110	2	27733644
Pubmed	Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.	FLRT3 FLRT1	2.97e-05	3	110	2	10644439
Pubmed	DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase.	TERT PRKDC	2.97e-05	3	110	2	15190070
Pubmed	Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.	PRKDC ATM	2.97e-05	3	110	2	17923115
Pubmed	DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.	PRKDC ATM	2.97e-05	3	110	2	29101015
Pubmed	DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.	PRKDC ATM	2.97e-05	3	110	2	31601897
Pubmed	Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.	PRKDC ATM	2.97e-05	3	110	2	25205036
Pubmed	ATM phosphorylates histone H2AX in response to DNA double-strand breaks.	PRKDC ATM	2.97e-05	3	110	2	11571274
Pubmed	Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase.	PRKDC ATM	2.97e-05	3	110	2	31164689
Pubmed	Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.	PRKDC ATM	2.97e-05	3	110	2	18755145
Pubmed	Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.	PRKDC ATM	2.97e-05	3	110	2	21224054
Pubmed	Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination.	PRKDC ATM	2.97e-05	3	110	2	31101667
Pubmed	The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF).	SCYL1 TERT	2.97e-05	3	110	2	24361335
Pubmed	The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.	PRKDC ATM	2.97e-05	3	110	2	10677503
Pubmed	The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity.	PRKDC ATM	2.97e-05	3	110	2	26049366
Pubmed	Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.	PRKDC ATM	2.97e-05	3	110	2	24794298
Pubmed	The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.	PRKDC ATM	2.97e-05	3	110	2	27160905
Pubmed	DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).	ERCC3 ATM	2.97e-05	3	110	2	28592488
Pubmed	[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells].	PRKDC ATM	2.97e-05	3	110	2	17626748
Pubmed	Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK.	PRKDC ATM	2.97e-05	3	110	2	25391321
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1 TAF1L	2.97e-05	3	110	2	16822332
Pubmed	A male with unilateral microphthalmia reveals a role for TMX3 in eye development.	TMX3 CCDC102A	2.97e-05	3	110	2	20485507
Pubmed	Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells.	NCK1 PLCG1	2.97e-05	3	110	2	9314836
Pubmed	Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.	PRKDC ATM	2.97e-05	3	110	2	19444312
Pubmed	Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.	PRKDC ATM	2.97e-05	3	110	2	15389585
Pubmed	Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.	PRKDC ATM	2.97e-05	3	110	2	21245316
Pubmed	TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.	TAF1 TAF1L	2.97e-05	3	110	2	11592977
Pubmed	The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.	PRKDC ATM	2.97e-05	3	110	2	16603769
Pubmed	Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.	TAF1 TAF1L	2.97e-05	3	110	2	12217962
Pubmed	TAF7: a possible transcription initiation check-point regulator.	TAF1 TAF1L	2.97e-05	3	110	2	16407123
Pubmed	Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.	PRKDC ATM	2.97e-05	3	110	2	21824916
Pubmed	Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.	PRKDC ATM	2.97e-05	3	110	2	28686579
Pubmed	ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks.	PRKDC ATM	2.97e-05	3	110	2	32890395
Pubmed	FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus.	FLRT3 FLRT1	5.92e-05	4	110	2	34955746
Pubmed	Gene structure of the murine 2'-5'-oligoadenylate synthetase family.	OAS3 OASL	5.92e-05	4	110	2	12222967
Pubmed	Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.	PRKDC ATM	5.92e-05	4	110	2	11158303
Pubmed	SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.	PRKDC ATM	5.92e-05	4	110	2	15998665
Pubmed	Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells.	FASN PRKDC	5.92e-05	4	110	2	23184344
Pubmed	Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes.	PRKDC ATM	5.92e-05	4	110	2	9716665
Pubmed	Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.	PRKDC ATM	5.92e-05	4	110	2	19000702
Pubmed	The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.	PRKDC ATM	5.92e-05	4	110	2	29954236
Pubmed	The MICAL proteins and rab1: a possible link to the cytoskeleton?	MICAL1 MICAL3	5.92e-05	4	110	2	15694364
Pubmed	Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80.	PRKDC ATM	5.92e-05	4	110	2	32944396
Pubmed	Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB.	ERCC3 TAF1	5.92e-05	4	110	2	35947745
Pubmed	Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.	PRKDC ATM	5.92e-05	4	110	2	19851285
Pubmed	Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.	OAS3 OASL	5.92e-05	4	110	2	21050126
Pubmed	DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.	TERT PRKDC	5.92e-05	4	110	2	17145779
Pubmed	Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.	PRKDC ATM	5.92e-05	4	110	2	22977523
Pubmed	Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.	PITPNA PLCG1	5.92e-05	4	110	2	7761838
Pubmed	Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.	PRKDC ATM	5.92e-05	4	110	2	28109743
Pubmed	Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.	PTPRA PIK3CB	5.92e-05	4	110	2	11676480
Pubmed	Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.	FLRT3 FLRT1	5.92e-05	4	110	2	16872596
Pubmed	Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.	NCK1 PLCG1	5.92e-05	4	110	2	9600074
Pubmed	Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.	GPR142 GPR132	5.92e-05	4	110	2	16378626
Pubmed	A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.	TERT BPTF	5.92e-05	4	110	2	22797724
Pubmed	Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.	MICAL1 MICAL3	5.92e-05	4	110	2	24440334
Interaction	UNC5D interactions	FLRT3 TAF1 FLRT1	6.52e-06	8	100	3	int:UNC5D
Interaction	THYN1 interactions	GALC GPX7 BBS9 PRKDC	9.17e-06	27	100	4	int:THYN1
Interaction	FOXP3 interactions	ERCC3 WDR36 NUP107 COPB2 INTS10 BPTF FASN PWP2 DYNC1LI1 TAF1 ATM	9.88e-06	432	100	11	int:FOXP3
Cytoband	14q32.33	IGHV1-18 IGHV1-8 IGHV1-3 IGHV1-2 IGHV7-4-1 IGHV7-81	1.96e-05	228	110	6	14q32.33
Cytoband	Ensembl 112 genes in cytogenetic band chr14q32	IGHV1-18 IGHV1-3 IGHV1-2 SERPINA13P IGHV7-4-1 IGHV7-81 GPR132	4.45e-04	566	110	7	chr14q32
Cytoband	12q24.2	OAS3 OASL	6.68e-04	16	110	2	12q24.2
GeneFamily	WD repeat domain containing	WDR36 WDR88 COPB2 WDR38 POC1B PWP2 CORO7	9.74e-05	262	74	7	362
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV1-18 IGHV1-8 IGHV1-3 IGHV1-2 IGHV7-4-1 IGHV7-81	1.17e-04	187	74	6	349
GeneFamily	WD repeat domain containing\|UTPB complex	WDR36 PWP2	2.45e-04	6	74	2	1225
Disease	dementia, Parkinson disease, disease progression measurement	BBS9 LRP1B	3.20e-05	3	97	2	EFO_0008336, MONDO_0001627, MONDO_0005180
Disease	Adenocarcinoma of lung (disorder)	PIGN DDR2 FASN PRKDC ATM TAF1L	6.27e-05	206	97	6	C0152013
Disease	lung non-small cell carcinoma (is_implicated_in)	ERCC3 TERT LRP1B PLCG1 ATM	9.82e-05	139	97	5	DOID:3908 (is_implicated_in)
Disease	colorectal cancer (is_marker_for)	ERCC3 FASN PIK3CB PLCG1 ATM	1.74e-04	157	97	5	DOID:9256 (is_marker_for)
Disease	erythronate measurement	DDR2 PTPRA	2.22e-04	7	97	2	EFO_0021025
Disease	rectum cancer	SLC24A3 LRP1B LRRC18	3.60e-04	42	97	3	EFO_1000657
Disease	nasopharynx carcinoma (is_marker_for)	DDR2 TERT ATM	3.86e-04	43	97	3	DOID:9261 (is_marker_for)
Disease	cutaneous melanoma	NOX4 TERT ATM CORO7	6.95e-04	121	97	4	EFO_0000389
Disease	Metastatic melanoma	SCYL1 PRKDC TAF1	7.56e-04	54	97	3	C0278883
Disease	Squamous cell carcinoma	ERCC3 DDR2 PRKDC ATM	7.61e-04	124	97	4	C0007137
Disease	melanoma	NOX4 TERT RAB5IF ATM	8.08e-04	126	97	4	EFO_0000756
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	NCK1 INTS10 FZD9 BPTF PLCG1	8.13e-04	220	97	5	EFO_0004529, EFO_0008317
Disease	serum gamma-glutamyl transferase measurement	DHDDS NCK1 FZD9 BPTF POC1B OASL MICAL3 PLCG1 FLRT1 NUDC	8.56e-04	914	97	10	EFO_0004532
Disease	lifestyle measurement, anxiety disorder measurement	FZD9 PIEZO2 CRACDL SDK1	1.10e-03	137	97	4	EFO_0007795, EFO_0010724
Disease	triglycerides to total lipids in very large HDL percentage	INTS10 BPTF FLRT1	1.13e-03	62	97	3	EFO_0022339
Disease	melanoma	ERCC3 TERT LRP1B FASN ATM	1.38e-03	248	97	5	C0025202
Disease	Benign Neoplasm	TERT FASN ATM	1.48e-03	68	97	3	C0086692
Disease	Neoplasms	TERT FASN ATM	1.48e-03	68	97	3	C0027651
Disease	apolipoprotein B measurement	AMPD2 NCK1 FZD9 BPTF DYNC1LI1 PLCG1 FLRT1 NUDC	1.56e-03	663	97	8	EFO_0004615
Disease	non-small cell lung carcinoma	TERT BPTF PIEZO2	1.96e-03	75	97	3	EFO_0003060
Disease	epilepsy (implicated_via_orthology)	SLC24A3 LRP1B SCN7A NUDC	2.09e-03	163	97	4	DOID:1826 (implicated_via_orthology)
Disease	Granulomatous Slack Skin	PLCG1 ATM	2.37e-03	22	97	2	C0376407
Disease	Lymphoma, T-Cell, Cutaneous	PLCG1 ATM	2.59e-03	23	97	2	C0079773
Disease	lung adenocarcinoma	TERT BPTF PIK3CB ATM	2.64e-03	174	97	4	EFO_0000571
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	INTS10 BPTF SPDEF NUDC MTMR9	2.78e-03	291	97	5	EFO_0008317, EFO_0020946
Disease	lung squamous cell carcinoma (is_implicated_in)	TERT ATM	2.82e-03	24	97	2	DOID:3907 (is_implicated_in)
Disease	myeloproliferative disorder	TERT ATM	3.05e-03	25	97	2	EFO_0004251

Protein segments in the cluster

Peptide	Gene	Start	Entry
WREARSLSWMQSPDL	LINC00479	41	Q96M42
TSSDDMLIKLWDWDK	COPB2	116	P35606
SWKLALPMTALRLSW	FLRT3	426	Q9NZU0
KWLAIVSWRMLHEAL	AGO1	131	Q9UL18
AHDWDREKLLEAWMS	ANKIB1	261	Q9P2G1
YWLDLKSSDIIWNMS	ACSM4	256	P0C7M7
IKSLLDAWSGWVVML	CLCN4	61	P51793
RSRDEWDKLARWAVM	AMPD2	546	Q01433
RLLWASLRWDDMAAK	BPTF	1911	Q12830
KVSVWSKVLRSDAAW	RAB5IF	21	Q9BUV8
WLDKWVDLTMDDIRR	PITPNA	231	Q00169
ETRVAWDLWSTLCMI	ITPRIP	81	Q8IWB1
IWKISCWRMAEDELF	NUP107	406	P57740
DLWAAKAWLITARSL	INTS10	21	Q9NVR2
KTDTWLWLRIFLTDM	INTS10	441	Q9NVR2
SSDLDLFRVWMGVWT	DNAJC14	281	Q6Y2X3
LAAMDSAWMVRSWSL	MICAL3	416	Q7RTP6
WRKLELNCWSMSLDN	MDN1	3811	Q9NU22
MDWTWSILFLVAAAT	IGHV7-81	1	A0A0B4J1V7
TALTIMDKKLWWADQ	LRP1B	1781	Q9NZR2
EASIWDLLLKVDMWD	MAGEE2	196	Q8TD90
LLDDSKSWWRVRNSM	NCK1	31	P16333
NMDRWLSKLEASNWL	MTMR9	291	Q96QG7
SLDWVWNLEKMDLSG	LRRTM1	251	Q86UE6
IRWMSWESILLGKFT	DDR2	751	Q16832
TAGESDMKIIRVLWW	ELOVL5	101	Q9NYP7
MRSSQTGDWTWLKEF	EDRF1	166	Q3B7T1
WLSADTKEERDLWMQ	ANLN	1086	Q9NQW6
DMSKPWTALDSLQKW	DYNC1LI1	151	Q9Y6G9
AILLASKVWSDMAVW	CCNYL2	241	Q5T2Q4
ENSRDSRLAWMGTWE	CORO7	211	P57737
MDWTWRILFLVAAAT	IGHV1-8	1	P0DP01
MIVDFLRERKTISWW	OR4K13	81	Q8NH42
DLLAERKVISWWGCM	OR4X2	76	Q8NGF9
ISPNSMAKDSWEDWR	LRRC18	241	Q8N456
MAKDSWEDWRIRLTS	LRRC18	246	Q8N456
TLMDTKWVTSELAWT	EPHB3	41	P54753
LAAFDAAWMVKRWAE	MICAL1	411	Q8TDZ2
TTMLSWVSFWIKTES	GABRE	291	P78334
KQLATASWDTFLMLW	POC1B	31	Q8TC44
MDWTWRILFLVAAAT	IGHV1-2	1	P23083
MWRSRWDASVLKAEA	MPPED1	1	O15442
MDWTWRILFLVAAAT	IGHV1-3	1	A0A0C4DH29
PSWMELARKKSQAWS	CRACDL	941	Q6NV74
RWEKWFMVTFASSTL	SLC24A3	471	Q9HC58
MSLFKARDWWSTILG	BBS9	1	Q3SYG4
MDWTWSILFLVAAAT	IGHV1-18	1	A0A0C4DH31
MAVSWRSWLANEGVK	NOX4	1	Q9NPH5
RLIWKTMWQSQDLLD	OASL	106	Q15646
PEKWDSMTRKWRDNS	HFM1	386	A2PYH4
MADWLKIRGTLKSWT	OSBPL8	151	Q9BZF1
MDWTWRILFLVAAAT	IGHV7-4-1	1	A0A0J9YVY3
RDKDFALVWMAVWSA	FZD9	226	O00144
DMWVFRLCSLWLENS	ATM	2481	Q13315
SKDSPKMSLEWLVAW	ASPHD2	21	Q6ICH7
TVSQGWKLIMWALSD	IGSF5	61	Q9NSI5
WKLIMWALSDMVVLS	IGSF5	66	Q9NSI5
WASMLACRLWKAISR	AQP6	11	Q13520
SDWWNPALRKRMLSD	DGKI	881	O75912
MTWDVELERSAESWA	CRISPLD1	86	Q9H336
EKTMRRWSDCTANWR	CCDC102A	91	Q96A19
RSADMWSFAVLLWEL	ILK	371	Q13418
WLDMWRDTDSPRTLD	GPR142	296	Q7Z601
RQSWSDKGSVWDRML	ERAP2	736	Q6P179
TTKRSWEAERVMEWL	ERCC3	416	P19447
CNLMWLRDWVKARAA	FLRT1	306	Q9NZU1
MVAATVAAAWLLLWA	GPX7	1	Q96SL4
DSGRLLWKDNWVSFM	FASN	1016	P49327
MAEWLLSASWQRRAK	GALC	1	P54803
MSWIKEGELSLWERF	DHDDS	1	Q86SQ9
SWPLEFKWMRDDSEL	SDK1	131	Q7Z5N4
VIEMSKFEAWSKRAW	CFAP47	1686	Q6ZTR5
MWVRTTLTIERWTKE	PROCA1	1	Q8NCQ7
WMEWEDLEAKTLDRR	LINC00597	31	Q9H2U6
STAWLWVRDMLTDEI	FOCAD	931	Q5VW36
IWEWKSCSIVMLTEL	PTPRA	621	P18433
EILSEMRASLESWWQ	OAS3	96	Q9Y6K5
WKEWSMKTDVTRLTH	GPR132	326	Q9UNW8
REWFWDLATGTMKER	HPX	166	P02790
AKRKMWQLVDPDSWS	RGSL1	251	A5PLK6
LGKNSEARWWMKLAL	RMDN3	431	Q96TC7
VLFLSSWKMVESARW	SLC22A24	271	Q8N4F4
VVREKWSADMWRLGC	SCYL1	196	Q96KG9
VSWLTMRVRKGFEDW	SLC16A14	286	Q7RTX9
MDSNWWVLKSDFRLP	TAF1L	876	Q8IZX4
GMDSNWWVLKSDFRL	TAF1	856	P21675
WTLESEALRRDMGTW	IL9R	11	Q01113
LSLVGLSWMDWLKQT	PIK3CB	161	P42338
DEALRESWTTKVNWM	PIK3CB	1046	P42338
EKINKMEWWSRLVSS	NUDC	246	Q9Y266
SWSDEKLWQLVAMAK	CNBD2	246	Q96M20
DACELLATAMWWKTR	SHANK2-AS3	41	Q9BTD1
METVFARSSWDWIGL	INPP5J	761	Q15735
MAAWKSWTALRLCAT	TMX3	1	Q96JJ7
VWVASEAWLTSDLVM	TAS1R3	296	Q7RTX0
KWILSASKDRTMRLW	WDR88	376	Q6ZMY6
LASASWDKTVRLWDM	PWP2	516	Q15269
RLWDMFDSWRTKETL	PWP2	526	Q15269
LDIWKSAAWMKERTS	SPDEF	206	O95238
MSSESTWDAWNERLL	STYXL2	471	Q5VZP5
ELRAVMDWVWTDTTL	PIEZO2	2346	Q9H5I5
SWWVMSNKTRDELER	TSPAN31	111	Q12999
SEDEVNMWIKGLTWL	PLCG1	126	P19174
MEASRWWLLVTVLMA	SERPINA13P	1	Q6UXR4
WSNWSVDALSKMVII	SRRD	231	Q9UH36
LTRLWTRAKMTSLSW	PIGN	581	O95427
LLLFERSWMNRWKSA	VPS41	151	P49754
KMWSRWNLSVDWKRT	PTH2R	426	P49190
SWWAKDSPLETKMAV	PRKDC	1631	P78527
SWDSTVHIWDLRMVT	WDR38	166	Q5JTN6
LMWSLSNSWVALKDL	SCN7A	616	Q01118
WEQRKLLRWKMSTVT	TTLL4	601	Q14679
QELTWKMSVRDCAWL	TERT	506	O14746
ADIEWKFARTKLWMS	TRPC4	631	Q9UBN4
WLISAAMDCSIRTWD	WDR36	636	Q8NI36