Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-glutamate uniporter activity	SLC17A7 SLC17A8	4.51e-05	3	78	2	GO:0140788
GeneOntologyMolecularFunction	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY1 CHSY3	8.99e-05	4	78	2	GO:0050510
GeneOntologyMolecularFunction	membrane potential driven uniporter activity	SLC17A7 SLC17A8	1.49e-04	5	78	2	GO:0022810
GeneOntologyMolecularFunction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	CHSY1 CHSY3	2.24e-04	6	78	2	GO:0047238
GeneOntologyBiologicalProcess	fourth ventricle development	MYH10 KDM2B	1.45e-05	2	79	2	GO:0021592
Domain	-	AP2A1 AP2A2	1.68e-05	2	77	2	2.60.40.1030
Domain	AP2_complex_asu	AP2A1 AP2A2	1.68e-05	2	77	2	IPR017104
Domain	Clathrin_a-adaptin_app_sub_C	AP2A1 AP2A2	1.68e-05	2	77	2	IPR003164
Domain	Clathrin_a-adaptin_app_Ig-like	AP2A1 AP2A2	1.68e-05	2	77	2	IPR013038
Domain	Alpha_adaptin_C	AP2A1 AP2A2	1.68e-05	2	77	2	PF02296
Domain	-	AP2A1 AP2A2	1.00e-04	4	77	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	AP2A1 AP2A2	1.00e-04	4	77	2	IPR015873
Domain	Coatomer/calthrin_app_sub_C	AP2A1 AP2A2	4.62e-04	8	77	2	IPR009028
Domain	Chond_GalNAc	CHSY1 CHSY3	4.62e-04	8	77	2	IPR008428
Domain	CHGN	CHSY1 CHSY3	4.62e-04	8	77	2	PF05679
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP2A2	5.93e-04	9	77	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP2A2	5.93e-04	9	77	2	PF02883
Domain	Alpha_adaptinC2	AP2A1 AP2A2	5.93e-04	9	77	2	SM00809
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP2A2	1.08e-03	12	77	2	IPR013041
Domain	LRRNT	FLRT3 FLRT1 BGN	1.36e-03	53	77	3	PF01462
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP2A2	1.70e-03	15	77	2	IPR002553
Domain	Adaptin_N	AP2A1 AP2A2	1.70e-03	15	77	2	PF01602
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ3 KCNJ8	1.94e-03	16	77	2	IPR013518
Domain	IRK	KCNJ3 KCNJ8	1.94e-03	16	77	2	PF01007
Domain	-	KCNJ3 KCNJ8	1.94e-03	16	77	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ3 KCNJ8	1.94e-03	16	77	2	IPR016449
Domain	zf-RanBP	ZRANB3 CAPN15	3.67e-03	22	77	2	PF00641
Domain	EPHD	TCF20 JADE3	3.67e-03	22	77	2	PS51805
Domain	ZnF_RBZ	ZRANB3 CAPN15	4.01e-03	23	77	2	SM00547
Domain	ZF_RANBP2_2	ZRANB3 CAPN15	4.01e-03	23	77	2	PS50199
Domain	ZF_RANBP2_1	ZRANB3 CAPN15	4.37e-03	24	77	2	PS01358
Domain	-	XXYLT1 CHSY1 CHSY3	4.56e-03	81	77	3	3.90.550.10
Domain	Znf_RanBP2	ZRANB3 CAPN15	4.73e-03	25	77	2	IPR001876
Domain	Nucleotide-diphossugar_trans	XXYLT1 CHSY1 CHSY3	5.75e-03	88	77	3	IPR029044
Domain	PHD	TCF20 JADE3 KDM2B	5.93e-03	89	77	3	SM00249
Domain	TRYPSIN_SER	PRSS27 TMPRSS4 C1S	6.12e-03	90	77	3	IPR033116
Domain	Znf_PHD	TCF20 JADE3 KDM2B	6.31e-03	91	77	3	IPR001965
Domain	ZF_PHD_2	TCF20 JADE3 KDM2B	7.11e-03	95	77	3	PS50016
Domain	ZF_PHD_1	TCF20 JADE3 KDM2B	7.31e-03	96	77	3	PS01359
Domain	SNF2_N	RAD54B ZRANB3	7.68e-03	32	77	2	IPR000330
Domain	SNF2_N	RAD54B ZRANB3	7.68e-03	32	77	2	PF00176
Domain	LRRNT	FLRT3 FLRT1 BGN	7.74e-03	98	77	3	IPR000372
Domain	LRRNT	FLRT3 FLRT1 BGN	7.74e-03	98	77	3	SM00013
Domain	VWF_A	MDN1 RO60 ITIH1	7.96e-03	99	77	3	IPR002035
Pathway	WP_SYNAPTIC_VESICLE_PATHWAY	AP2A1 AP2A2 SLC17A7 SLC17A8	4.20e-05	51	54	4	M39457
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3 BGN	4.93e-05	19	54	3	MM14800
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3 BGN	5.78e-05	20	54	3	M658
Pathway	REACTOME_NEF_MEDIATED_CD8_DOWN_REGULATION	AP2A1 AP2A2	2.99e-04	7	54	2	M27044
Pathway	REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS	CHSY1 BGN	3.97e-04	8	54	2	M27261
Pathway	KEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	3.97e-04	8	54	2	M47920
Pathway	REACTOME_NEF_MEDIATED_CD4_DOWN_REGULATION	AP2A1 AP2A2	5.10e-04	9	54	2	M27011
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	7.75e-04	11	54	2	MM14694
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHSY1 CHSY3 BGN	8.14e-04	48	54	3	MM14696
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHSY1 CHSY3 BGN	9.17e-04	50	54	3	M678
Pathway	REACTOME_ORGANIC_ANION_TRANSPORTERS	SLC17A7 SLC17A8	9.27e-04	12	54	2	M27350
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	9.27e-04	12	54	2	MM15163
Pathway	REACTOME_ORGANIC_ANION_TRANSPORTERS	SLC17A7 SLC17A8	9.27e-04	12	54	2	MM15087
Pubmed	Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine).	SYK CX3CL1	5.09e-06	2	79	2	16148119
Pubmed	Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages.	SYK CX3CL1	5.09e-06	2	79	2	21388954
Pubmed	Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).	AP2A1 AP2A2	5.09e-06	2	79	2	2564002
Pubmed	Chondroitin sulfate synthase-3. Molecular cloning and characterization.	CHSY1 CHSY3	5.09e-06	2	79	2	12907687
Pubmed	Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.	AP2A1 AP2A2	5.09e-06	2	79	2	12036598
Pubmed	Synaptic and extrasynaptic factors governing glutamatergic retinal waves.	SLC17A7 SLC17A8	5.09e-06	2	79	2	19409268
Pubmed	Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.	AP2A1 AP2A2	1.53e-05	3	79	2	35014951
Pubmed	A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.	AP2A1 AP2A2	1.53e-05	3	79	2	18032517
Pubmed	AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.	AP2A1 AP2A2	1.53e-05	3	79	2	22262466
Pubmed	Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.	CHSY1 CHSY3	1.53e-05	3	79	2	33089528
Pubmed	Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.	AP2A1 AP2A2	1.53e-05	3	79	2	26269175
Pubmed	Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.	SLC17A7 SLC17A8	1.53e-05	3	79	2	23467360
Pubmed	Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.	FLRT3 FLRT1	1.53e-05	3	79	2	10644439
Pubmed	A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.	AP2A1 AP2A2	1.53e-05	3	79	2	19129443
Pubmed	Interaction of Shc with adaptor protein adaptins.	AP2A1 AP2A2	1.53e-05	3	79	2	8617812
Pubmed	Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels.	SLC17A7 SLC17A8	1.53e-05	3	79	2	33440152
Pubmed	The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.	AP2A1 AP2A2	1.53e-05	3	79	2	8662627
Pubmed	Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.	SLC17A7 SLC17A8	1.53e-05	3	79	2	17660252
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	MYH10 AP2A1 AP2A2 COPS2 HNRNPU	2.94e-05	156	79	5	22952844
Pubmed	Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein.	SYK HNRNPU	3.05e-05	4	79	2	7831290
Pubmed	FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus.	FLRT3 FLRT1	3.05e-05	4	79	2	34955746
Pubmed	The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.	AP2A1 AP2A2	3.05e-05	4	79	2	12646615
Pubmed	Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.	FLRT3 FLRT1	3.05e-05	4	79	2	16872596
Pubmed	Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.	AP2A1 AP2A2	3.05e-05	4	79	2	20500056
Pubmed	DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.	DPP9 SYK	3.05e-05	4	79	2	27614019
Pubmed	Association and colocalization of Eps15 with adaptor protein-2 and clathrin.	AP2A1 AP2A2	3.05e-05	4	79	2	9049247
Pubmed	Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.	CHSY1 CHSY3	3.05e-05	4	79	2	21468578
Pubmed	Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons.	FLRT3 FLRT1	3.05e-05	4	79	2	31928845
Pubmed	Weak Molecular Interactions in Clathrin-Mediated Endocytosis.	AP2A1 AP2A2	5.07e-05	5	79	2	29184887
Pubmed	A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.	AP2A1 AP2A2	5.07e-05	5	79	2	17108326
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	AP2A1 AP2A2	5.07e-05	5	79	2	9723620
Pubmed	Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy.	SLC17A7 SLC17A8	5.07e-05	5	79	2	36595933
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP2C18 CYP3A4	5.07e-05	5	79	2	11093772
Pubmed	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.	AP2A1 AP2A2	5.07e-05	5	79	2	16139856
Pubmed	Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.	AP2A1 AP2A2	5.07e-05	5	79	2	31671891
Pubmed	Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.	AP2A1 AP2A2	5.07e-05	5	79	2	15941406
Pubmed	Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.	AP2A1 AP2A2	7.60e-05	6	79	2	22650988
Pubmed	Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.	AP2A1 AP2A2	7.60e-05	6	79	2	22713487
Pubmed	The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.	AP2A1 AP2A2	7.60e-05	6	79	2	12121421
Pubmed	Clathrin.	AP2A1 AP2A2	7.60e-05	6	79	2	10966473
Pubmed	Molecular architecture and functional model of the endocytic AP2 complex.	AP2A1 AP2A2	7.60e-05	6	79	2	12086608
Pubmed	HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.	AP2A1 AP2A2	7.60e-05	6	79	2	15020715
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	CHSY1 CHSY3	1.06e-04	7	79	2	17145758
Pubmed	Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.	AP2A1 AP2A2	1.06e-04	7	79	2	20351096
Pubmed	Clathrin interacts specifically with amphiphysin and is displaced by dynamin.	AP2A1 AP2A2	1.06e-04	7	79	2	9280305
Pubmed	Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.	AP2A1 AP2A2	1.06e-04	7	79	2	7671305
Pubmed	Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.	AP2A1 AP2A2	1.06e-04	7	79	2	16103193
Pubmed	Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.	AP2A1 AP2A2	1.06e-04	7	79	2	23676497
Pubmed	Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.	CYP2C18 CYP3A4	1.41e-04	8	79	2	18794335
Pubmed	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.	AP2A1 AP2A2	1.41e-04	8	79	2	2014052
Pubmed	Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.	AP2A1 AP2A2	1.41e-04	8	79	2	11879655
Pubmed	Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells.	CHSY1 CHSY3	1.41e-04	8	79	2	6781479
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	MDN1 GTF3C1 CPSF3 HNRNPU	1.46e-04	116	79	4	21549307
Pubmed	Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage.	AP2A1 AP2A2 SLC17A7	1.70e-04	47	79	3	31235642
Pubmed	Accessory protein recruitment motifs in clathrin-mediated endocytosis.	AP2A1 AP2A2	1.82e-04	9	79	2	12057195
Pubmed	Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.	AP2A1 AP2A2	1.82e-04	9	79	2	11591131
Pubmed	Enteroendocrine cell types that drive food reward and aversion.	SLC17A7 SLC17A8	1.82e-04	9	79	2	35913117
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MAST4 JADE3 KDM2B CHSY1 HMGXB3 FLRT3 NPEPL1	2.04e-04	529	79	7	14621295
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	AP2A1 AP2A2	2.27e-04	10	79	2	25898166
Pubmed	HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.	AP2A1 AP2A2	2.27e-04	10	79	2	17581864
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	FLRT3 FLRT1	2.27e-04	10	79	2	38713721
Pubmed	Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.	SLC17A7 FLRT3 FLRT1	2.30e-04	52	79	3	24613359
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	MYH10 AP2A1 AP2A2 HNRNPU	2.32e-04	131	79	4	28634551
Pubmed	The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.	AP2A1 AP2A2 HNRNPU	2.57e-04	54	79	3	18495661
Pubmed	Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.	AP2A1 AP2A2	2.76e-04	11	79	2	31388001
Pubmed	HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization.	AP2A1 AP2A2	2.76e-04	11	79	2	19802344
Pubmed	Defining the membrane proteome of NK cells.	MDN1 GTF3C1 AP2A1 HSDL2 MED16 EML4 HLA-F CHSY1 KDSR HNRNPU	3.09e-04	1168	79	10	19946888
Pubmed	SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.	MYH10 AP2A1	3.31e-04	12	79	2	26787558
Pubmed	C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.	NPPB SLC17A7	3.31e-04	12	79	2	19805384
Pubmed	Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.	CHSY1 CHSY3	3.31e-04	12	79	2	29287114
Pubmed	Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.	CHSY1 CHSY3	3.31e-04	12	79	2	36047655
Pubmed	CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.	CYP2C18 CYP3A4	3.31e-04	12	79	2	15319333
Pubmed	Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.	FLRT3 FLRT1	3.31e-04	12	79	2	26960425
Pubmed	FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons.	FLRT3 FLRT1	3.31e-04	12	79	2	21673655
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	MYH10 GTF3C1 AP2A1 AP2A2 CPSF3 HNRNPU	3.53e-04	411	79	6	36652389
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CYP2C18 MDN1 TCF20 GTF3C1 JADE3 EML4 RALGAPB KDM2B	3.77e-04	774	79	8	15302935
Pubmed	Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population.	DPYD CYP3A4	3.91e-04	13	79	2	16771603
Pubmed	Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.	DPYD CYP3A4	3.91e-04	13	79	2	20530282
Pubmed	Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.	FLRT3 FLRT1	3.91e-04	13	79	2	28475893
Pubmed	Influence of ethnicity on pharmacogenetic variation in the Ghanaian population.	DPYD CYP3A4	3.91e-04	13	79	2	19546880
Pubmed	Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.	FLRT3 FLRT1	3.91e-04	13	79	2	18448090
Pubmed	Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.	AP2A1 AP2A2	3.91e-04	13	79	2	9882340
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	MYH10 AP2A1 AP2A2 HLA-F	4.51e-04	156	79	4	30409884
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	GTF3C1 AP2A1 AP2A2 HERC1 KDSR COPS2 CAPN15	4.53e-04	604	79	7	38803224
Pubmed	Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial.	DPYD CYP3A4	4.55e-04	14	79	2	19636001
Pubmed	Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor.	AP2A1 AP2A2	4.55e-04	14	79	2	11157096
Pubmed	Redundant and nonredundant organismal functions of EPS15 and EPS15L1.	AP2A1 AP2A2	4.55e-04	14	79	2	30692166
Pubmed	APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.	AP2A1 AP2A2	4.55e-04	14	79	2	29262337
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	MDN1 AP2A2 CYP3A4 RALGAPB HLA-F XXYLT1 HMGXB3 MYRFL HERC1 CPSF3	5.01e-04	1242	79	10	30973865
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	AP2A1 AP2A2	5.25e-04	15	79	2	21307259
Pubmed	International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.	KCNJ3 KCNJ8	5.25e-04	15	79	2	16382105
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	MDN1 DENND5A	5.25e-04	15	79	2	19762545
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	DPP9 MED16 ETS1 KDSR CSMD3	5.56e-04	293	79	5	31741433
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	AP2A1 AP2A2	5.99e-04	16	79	2	24305805
Pubmed	HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.	AP2A1 AP2A2	5.99e-04	16	79	2	21762802
Pubmed	Intersectional mapping of multi-transmitter neurons and other cell types in the brain.	SLC17A7 SLC17A8	5.99e-04	16	79	2	35793636
Pubmed	PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.	AP2A1 AP2A2	5.99e-04	16	79	2	16055064
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	DPYD CNNM2 TCF20 COA8 ITIH1	6.46e-04	303	79	5	25056061
Pubmed	Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.	MYH10 HNRNPU	6.78e-04	17	79	2	19759019
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	ZNF469 MYH10 AP2A1 AP2A2 SYK CPSF3 HNRNPU	7.18e-04	653	79	7	33742100
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ3 KCNJ8	1.14e-03	16	57	2	276
GeneFamily	Beta 4-glycosyltransferases	CHSY1 CHSY3	1.29e-03	17	57	2	425
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	ZRANB3 CAPN15	1.97e-03	21	57	2	89
GeneFamily	Beta 3-glycosyltransferases	CHSY1 CHSY3	2.58e-03	24	57	2	426
Coexpression	STARK_HYPPOCAMPUS_22Q11_DELETION_UP	AP2A2 SLC17A7 CX3CL1 HNRNPU	2.00e-05	53	79	4	MM582
Coexpression	STARK_HYPPOCAMPUS_22Q11_DELETION_UP	AP2A2 SLC17A7 CX3CL1 HNRNPU	2.16e-05	54	79	4	M12050
Coexpression	GSE22589_HIV_VS_HIV_AND_SIV_INFECTED_DC_DN	CNNM2 MED16 KDM2B ARMCX4 CPSF3 CAPN15	3.20e-05	200	79	6	M7801
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 KCNJ8 C11orf96 SLC17A7 C1S BGN	8.23e-07	180	79	6	ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 MYH10 CEP295NL C1S ACSM5 BGN	1.43e-06	198	79	6	08d393853e195a7eacace454153e425a273e2d23
ToppCell	medial-2-mesenchymal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FKBP10 MYH10 KCNJ8 C11orf96 C1S BGN	1.52e-06	200	79	6	a9d8aa5bcf383d98a9e2eaf4b1f8466982d6b088
ToppCell	distal-mesenchymal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FKBP10 MYH10 KCNJ8 C11orf96 C1S BGN	1.52e-06	200	79	6	b54137a4545690f51e154bb05964eaa650c3ca8e
ToppCell	distal-2-mesenchymal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FKBP10 MYH10 KCNJ8 C11orf96 C1S BGN	1.52e-06	200	79	6	65a50f03b0027ccefb51b8f77afa283d4a3b3567
ToppCell	medial-mesenchymal\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FKBP10 MYH10 KCNJ8 C11orf96 C1S BGN	1.52e-06	200	79	6	4f19e1e40966e27779bf77e8c170ed3ecc24353e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DCHS2 KCNJ8 SYK FREM1 BGN	8.88e-06	157	79	5	beab0ac47202266b04543c02cfcdda012375e879
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNJ8 C11orf96 FZD10 CHSY3 BGN	9.44e-06	159	79	5	7a5c94c87b73f928d4daee507f32cbe7d90e4478
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 KCNJ8 SLC17A7 C1S BGN	1.10e-05	164	79	5	01a7c335897128d3478b8b9b44fb461cab493084
ToppCell	ICU-SEP-Lymphocyte-T_NK-dnT\|ICU-SEP / Disease, Lineage and Cell Type	CNNM2 MAST4 GTF3C1 ESM1 ELP4	1.16e-05	166	79	5	96d92316cee20b722fe782db9dafcceb8f2c220b
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ZNF469 ETS1 CHSY1 OTOL1 BGN	1.23e-05	168	79	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNJ8 C11orf96 C1S CHSY3 BGN	1.38e-05	172	79	5	1ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNJ8 C11orf96 C1S CHSY3 BGN	1.38e-05	172	79	5	ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FKBP10 ZNF469 C11orf96 C1S BGN	1.72e-05	180	79	5	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FKBP10 ZNF469 C11orf96 C1S BGN	1.72e-05	180	79	5	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD SLC17A8 C1S ACSM5 ITIH1	1.81e-05	182	79	5	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYH10 KCNJ3 SYK HUNK FREM1	1.81e-05	182	79	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD SLC17A8 C1S ACSM5 ITIH1	1.81e-05	182	79	5	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD SLC17A8 C1S ACSM5 ITIH1	1.81e-05	182	79	5	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNJ3 SYK HUNK MYRFL FREM1	1.86e-05	183	79	5	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH10 C11orf96 C1S FREM1 BGN	2.01e-05	186	79	5	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GTF3C1 EML4 ETS1 KDSR SLAMF1	2.07e-05	187	79	5	f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCell	E17.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYH10 CNNM2 KCNJ8 C11orf96 BGN	2.07e-05	187	79	5	0dee138738b65531ff134a125b92234b5d0a653c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 KCNJ8 C11orf96 C1S BGN	2.17e-05	189	79	5	9e1a51997ef9b6999d9b40cf0a55e561e3b4a84c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 KCNJ8 C11orf96 C1S BGN	2.23e-05	190	79	5	7f6dafd5418764d67f6d5ec2153233b791910e81
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNJ8 C11orf96 ETS1 FZD10 BGN	2.34e-05	192	79	5	09cb5b89a164ac7444774ccc8c90323c8ea2026b
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)\|368C / Donor, Lineage, Cell class and subclass (all cells)	MYH10 C11orf96 MYRFL ITIH1 BGN	2.40e-05	193	79	5	5182284dfa7c94027e94172e08f78c86b95d63f4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 KCNJ8 C11orf96 C1S BGN	2.40e-05	193	79	5	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	MYH10 C11orf96 MYRFL ITIH1 BGN	2.40e-05	193	79	5	4f7bab0115469c855160636d168bd6e5d4e2dd2f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 KCNJ8 C11orf96 C1S BGN	2.40e-05	193	79	5	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	tumor_Lung\|World / Location, Cell class and cell subclass	MAST4 EML4 C11orf96 C1S BGN	2.46e-05	194	79	5	7e6b8a30f8d08252ad3f1df826d6f7c0ba997c2c
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP10 MYH10 C11orf96 C1S BGN	2.46e-05	194	79	5	d47e3c7b22444aef0c7a37bc8cd8853b590a56dd
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP10 MYH10 C1S FREM1 BGN	2.52e-05	195	79	5	18b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNJ8 C11orf96 ETS1 CHSY3 BGN	2.52e-05	195	79	5	d760d1423f9a8a373fe7b250ea9b1d67a0c0059f
ToppCell	(5)_Fibroblast-K_(Pericytes)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MYH10 C11orf96 MYRFL ITIH1 BGN	2.59e-05	196	79	5	e3c89c5bd674289738d5590ebfd30c605f5156a5
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CNNM2 KCNJ8 C11orf96 COLEC10 BGN	2.65e-05	197	79	5	fd65a9b41df618ff2a09d76dcf9f1ca3f3bdf52a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 DCHS2 C1S FREM1 BGN	2.65e-05	197	79	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FKBP10 MYH10 KCNJ8 C11orf96 BGN	2.72e-05	198	79	5	b2d295e330772bd8e24da356c75564b4297ea9c5
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FKBP10 MYH10 KCNJ8 C11orf96 BGN	2.72e-05	198	79	5	ce59ee3d970397eb62d6387699c6c6cd65457898
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 KCNJ8 C11orf96 C1S BGN	2.72e-05	198	79	5	d83707b69fb64721ac3cff90ba58cdd999d6b386
ToppCell	background-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	CYP3A4 C1S CHSY3 COLEC10 BGN	2.72e-05	198	79	5	79f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYH10 C11orf96 C1S MYRFL BGN	2.72e-05	198	79	5	c7075dce915ab8387309fcb12c5f6a17d4100cda
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FKBP10 MYH10 KCNJ8 C11orf96 BGN	2.72e-05	198	79	5	3ffaea4b44067d69f954b2bd3119c88a55ab232a
ToppCell	stromal_cell\|World / Lineage and Cell class	C11orf96 ESM1 C1S ACSM5 BGN	2.78e-05	199	79	5	507a82d0529b5b1fa5aebcfe43db53f0b6e3f8f0
ToppCell	stromal_cell-stromal_cell\|World / Lineage and Cell class	C11orf96 ESM1 C1S ACSM5 BGN	2.78e-05	199	79	5	74262363a34da3a1eb55ab375fd61ddd7bb39b23
ToppCell	metastatic_Brain-Fibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	FKBP10 KCNJ8 C11orf96 C1S BGN	2.78e-05	199	79	5	63eb2106bb6e2e33d020628583536c8d96662c84
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GTF3C1 EML4 HLA-F ETS1 SLAMF1	2.78e-05	199	79	5	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MYH10 C11orf96 C1S MYRFL BGN	2.78e-05	199	79	5	7c272a1aa7f3e931ad5d20809719d85b3bce4cb0
ToppCell	distal-2-mesenchymal-Airway_Smooth_Muscle\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYH10 C11orf96 C1S MYRFL BGN	2.78e-05	199	79	5	af226a6c50747dad9ca696463e715913b3ac17c0
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-dn_T\|ICU-NoSEP / Disease, condition lineage and cell class	GTF3C1 MED16 ETS1 ZRANB3 ELP4	2.78e-05	199	79	5	7fb211f803a8b3a2cfa9455386abea08131c6b52
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	c3d4ce70ab51d74c9fe2f5864e52a4a9d7570e10
ToppCell	distal-1-mesenchymal\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	7623f82bd85a0ff7e2097e9281551208dfc602a8
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	3'-Parenchyma_lung-Mesenchymal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	ba5ed66b05caa1be0bbf8d54c4e72a782b8d9833
ToppCell	Parenchymal-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	2e525c0d9684e7a2275edb04e1addb6fc6a872e5
ToppCell	mild-MAIT\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GTF3C1 EML4 ETS1 KDSR SLAMF1	2.85e-05	200	79	5	1e3ef15ce48b9a19a6ac3e08ea0234a9376e6596
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-gd_T\|ICU-NoSEP / Disease, condition lineage and cell class	MYH10 GTF3C1 FSCN3 ETS1 QRICH2	2.85e-05	200	79	5	2c2cea7691c340912f6ad77667a580a071eaeb8b
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	137f8f9d255c66336d4f8b44b2e3f3de721f2bf0
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	MDN1 MAST4 ETS1 KDSR SLAMF1	2.85e-05	200	79	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Parenchymal-10x3prime_v2-Stromal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	f6be0f24e607abb9007823a54fb0b24d04990a89
ToppCell	severe-MAIT\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GTF3C1 EML4 HLA-F ETS1 SLAMF1	2.85e-05	200	79	5	1daf43f1bdd49585dce5e957820554d7f3c1bd4a
ToppCell	distal-mesenchymal-Airway_Smooth_Muscle-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYH10 C11orf96 C1S MYRFL BGN	2.85e-05	200	79	5	f09eaa52e11262ec47f3dcb4d890e240eaaa2b3d
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-dn_T\|ICU-SEP / Disease, condition lineage and cell class	CNNM2 MAST4 GTF3C1 ESM1 ELP4	2.85e-05	200	79	5	9ee3e18dc429b9c472e3e366d9bfdbb150daa369
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KCNJ8 C11orf96 C1S ITIH1 BGN	2.85e-05	200	79	5	38190e4b32f7469df1da7d130bca6d7b12a3dd06
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	fd92d8250c6ad1e8bb46b303ac37f8dcf80387d8
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	25d3865aa2ced11a5ed40013e83b47d942fdf582
ToppCell	Biopsy_Other_PF-Mesenchymal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	FKBP10 MYH10 C11orf96 C1S BGN	2.85e-05	200	79	5	d6fcdd48858b53b5a8d18ae14b2dc4d9af41b070
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CNNM2 KCNJ8 C11orf96 PRDM15	1.07e-04	138	79	4	8d70e64843f7c3be8ee4203cc126fdf1001f0df5
ToppCell	3'_v3-Lung-Lymphocytic_T_CD8-Trm_gut_CD8\|Lung / Manually curated celltypes from each tissue	FKBP10 ETS1 SLC17A8 SLAMF1	1.16e-04	141	79	4	7cbe8abdd004430d58ce31e0b613894a4cf6726e
ToppCell	Leuk-UTI-Lymphocyte-T_NK-MAIT\|Leuk-UTI / Disease, Lineage and Cell Type	FKBP10 CNNM2 ETS1 CX3CL1	1.58e-04	153	79	4	ac3a1d1b5bf6009df818fd757dad7382d95c60dc
ToppCell	Bac-SEP-Lymphocyte-T_NK-MAIT\|Bac-SEP / Disease, Lineage and Cell Type	GTF3C1 EML4 FSCN3 ETS1	1.84e-04	159	79	4	e043c65f3febdfa7f75a67702e92fcdebe144a00
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNJ8 C11orf96 C1S CHSY3	1.84e-04	159	79	4	cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNJ8 C11orf96 C1S CHSY3	1.84e-04	159	79	4	a75ab494959575143cefdaec99e7aee3f318d559
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNJ8 C11orf96 CHSY3 BGN	1.97e-04	162	79	4	c5eee02836efde2108534679850c28d2b2cfce3f
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 RAD54B SYK SLAMF1	2.02e-04	163	79	4	66ecd544d7b52e61880b125bf39d1f406af6900a
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-MAIT_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPYD GTF3C1 ETS1 ESM1	2.16e-04	166	79	4	e4f14b2dd8c6199fa27cc3e3beeda681a3b5b889
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF469 KCNJ8 C1S BGN	2.32e-04	169	79	4	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DCHS2 KCNJ8 C11orf96 FZD10	2.42e-04	171	79	4	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF469 KCNJ8 C1S BGN	2.42e-04	171	79	4	15cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 SLC17A8 FREM1	2.51e-04	69	79	3	0862e6c8d8af4310b9a1f0879e51ee25115b26b1
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 SLC17A8 FREM1	2.51e-04	69	79	3	d2ff9cea216122d697822cdd2eecbce8f557728d
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	FKBP10 MYH10 C1S BGN	2.53e-04	173	79	4	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DCHS2 TMPRSS4 HUNK CX3CL1	2.53e-04	173	79	4	464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell	343B-Fibroblasts-Fibroblast-H-\|343B / Donor, Lineage, Cell class and subclass (all cells)	FZD10 C1S FREM1 BGN	2.59e-04	174	79	4	2627c3983009839fedbc5e3f628739dc026447f4
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DCHS2 MYH10 KCNJ8 FREM1	2.59e-04	174	79	4	9d22a554617a93701d0945de63cc3e7b24322c40
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM169 TMPRSS4 COLEC10 HUNK	2.59e-04	174	79	4	46bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCell	343B-Fibroblasts-Fibroblast-H\|343B / Donor, Lineage, Cell class and subclass (all cells)	FZD10 C1S FREM1 BGN	2.59e-04	174	79	4	507a33e58f62e2b72f0bcc743e84dbd0bf705a15
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	DCHS2 KCNJ8 C11orf96 BGN	2.70e-04	176	79	4	2015539c58aa0bb118e111ffedd63dd9fe863bb1
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	FKBP10 KCNJ3 C1S CSMD3	2.70e-04	176	79	4	fc5787946f5a10056d326d070620575ae4081836
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	FKBP10 KCNJ3 C1S CSMD3	2.70e-04	176	79	4	5daaba0853afe7d20d4635169ccd4f96e735b938
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTOV1 TMPRSS4 ESM1 HUNK	2.70e-04	176	79	4	d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	MYH10 C1S PCDHA6 BGN	2.76e-04	177	79	4	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 C11orf96 CSMD3 BGN	2.76e-04	177	79	4	ac90e4ce5be304a5a7473736397327010f2d1999
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MYH10 C1S PCDHA6 BGN	2.76e-04	177	79	4	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	MDN1 FLRT1 HERC1 CSMD3	2.76e-04	177	79	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-F SLC17A8 MYRFL FREM1	2.82e-04	178	79	4	39889db130216655a34796e7030ffeb372465500
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a6-Slc17a7.Fezf2.3110035E14Rik_(Deep_layer_pyramidal_cells-Layer_5b)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC17A8 TMPRSS4 SLAMF1	2.85e-04	72	79	3	4f424d2d4e62f212881189f3e99cec22048438f0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAST4 EML4 ETS1 SLAMF1	2.95e-04	180	79	4	6bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCell	droplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C11orf96 C1S CSMD3 BGN	2.95e-04	180	79	4	b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
Drug	Clobetasol propionate [25122-46-7]; Down 200; 8.6uM; MCF7; HT_HG-U133A	NUDT18 CNNM2 MAST4 MED16 TMEM209 PCDHA6 DENND5A	5.59e-06	197	79	7	6095_DN
Drug	Eucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	FKBP10 AP2A2 MED16 SLC17A7 FZD10 C1S BGN	5.97e-06	199	79	7	3759_UP
Drug	Avermectin B1 [71751-41-2]; Up 200; 4.8uM; PC3; HT_HG-U133A	MAST4 CYP3A4 FSCN3 KCNJ8 RAD54B SLC17A7 FZD10	5.97e-06	199	79	7	5864_UP
Drug	ivabradine	NPPB CYP3A4 KCNJ3 KCNJ8	1.01e-05	39	79	4	CID000132999
Disease	unipolar depression, systolic blood pressure	NPPB CNNM2 OTOL1	9.65e-05	34	77	3	EFO_0003761, EFO_0006335
Disease	Parkinsonism (biomarker_via_orthology)	KCNJ8 SLC17A8 CX3CL1	9.65e-05	34	77	3	DOID:0080855 (biomarker_via_orthology)
Disease	fractalkine measurement	MED16 CX3CL1	1.00e-04	6	77	2	EFO_0020395
Disease	segment polarity protein dishevelled homolog DVL-2 measurement	C1S ITIH1	1.00e-04	6	77	2	EFO_0802044
Disease	SLAM family member 5 measurement	SLAMF1 ITIH1	1.40e-04	7	77	2	EFO_0020741
Disease	axin-2 measurement	MED16 ITIH1	2.98e-04	10	77	2	EFO_0801400
Disease	Tachycardia, Ventricular	NPPB KCNJ8	3.64e-04	11	77	2	C0042514
Disease	Atrial Fibrillation	NPPB KCNJ8 XXYLT1 HERC1	8.28e-04	160	77	4	C0004238
Disease	non-small cell lung carcinoma	XXYLT1 SLC17A8 COPS2	1.01e-03	75	77	3	EFO_0003060
Disease	metabolonic lactone sulfate measurement	CYP2C18 CYP3A4	1.12e-03	19	77	2	EFO_0800659
Disease	nephrosis (biomarker_via_orthology)	NPPB CX3CL1	1.50e-03	22	77	2	DOID:2527 (biomarker_via_orthology)
Disease	feeling nervous measurement	DPYD CNNM2 ITIH1	1.55e-03	87	77	3	EFO_0009597
Disease	Cardiac Arrhythmia	CNNM2 KCNJ8	1.94e-03	25	77	2	C0003811
Disease	sciatic neuropathy (biomarker_via_orthology)	KCNJ8 SLC17A7 SLC17A8	2.24e-03	99	77	3	DOID:11446 (biomarker_via_orthology)
Disease	eye measurement	ZNF469 HERC1	2.26e-03	27	77	2	EFO_0004731
Disease	necrotizing enterocolitis	TCF20 OTOL1	2.26e-03	27	77	2	EFO_0003928
Disease	cognitive function measurement, self reported educational attainment	DPYD TCF20 KCNJ3 HLA-F ITIH1	2.38e-03	355	77	5	EFO_0004784, EFO_0008354
Disease	intelligence, response to cranial radiation therapy	DCHS2 GTF3C1	2.43e-03	28	77	2	EFO_0004337, EFO_0010950
Disease	respiratory failure, COVID-19	DPP9 FREM1	2.61e-03	29	77	2	EFO_0009686, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
EMQECGAGTPRGKKM	CEP295NL	381	Q96MC4
CFDPGNIMNGTRLGM	CSMD3	1701	Q7Z407
PLIMGVIRECGGKMH	COPS2	231	P61201
KIMLDCGIHPGLEGM	CPSF3	36	Q9UKF6
GLMCQAPEKVRGMAI	FLRT3	331	Q9NZU0
MPAVSKGDGMRGLAV	AP2A1	1	O95782
LGGACGLQPGDRMML	ACSM5	106	Q6NUN0
CRIRGGMLAMPKDEA	COLEC10	176	Q9Y6Z7
ELNLSCPHGMGERGM	DPYD	666	Q12882
DDMPGTGVEDMGNCK	ARMCX4	291	Q5H9R4
MPAVSKGDGMRGLAV	AP2A2	1	O94973
MNGRCGAILADEMGL	RAD54B	316	Q9Y620
PLGMDQRGCVISGMG	QRICH2	321	Q9H0J4
LQGMNGCDMGPDGRL	HLA-F	116	P30511
QRVCSGEGPPKMDLM	PCDHA6	756	Q9UN73
LMGASCGGGNMKVDD	CAPN15	691	O75808
ATPAKEMGMGNVERC	MDN1	4211	Q9NU22
IGFGGRMMTEECPLA	KCNJ8	141	Q15842
MDGAMGPRGLLLCMY	ITIH1	1	P19827
VTACGLDPMEQRGGM	NUDT18	216	Q6ZVK8
VTAMLEKGERMGCPA	SYK	581	P43405
GEKVKICDMQMRGTP	HERC1	2181	Q15751
GSGPRNCIGMRFALM	CYP3A4	436	P08684
DMICGICGVAPKVEM	HMGXB3	881	Q12766
MCMGRTSRGKLGGQD	ETS1	236	P14921
TMPGMKRDCGGAAAV	NPEPL1	276	Q8NDH3
GLRNMNCIEMGGNPL	BGN	181	P21810
LKADLMPVMNCSEGG	FREM1	891	Q5H8C1
DCEVVMMIGLPGAGK	HNRNPU	496	Q00839
PDEALVVCGNMKVMG	MYRFL	431	Q96LU7
MDMLGGPGIESQCRK	HSDL2	206	Q6YN16
MVQGSGCFGRKMDRI	NPPB	106	P16860
MCDLRRPAAGGMMDL	MED16	1	Q9Y2X0
KGLCRIMGNGFAGCM	PTOV1	176	Q86YD1
MSPCGRKMGEGRQQR	DCHS2	1	Q6V1P9
ISSMDMERPGDGKCQ	FZD10	21	Q9ULW2
IKGMDQGLLGMCPGE	FKBP10	211	Q96AY3
FGGPGRMKQSCIMRQ	KDM2B	636	Q8NHM5
HCRDGGKNGFMVSPM	DPP9	161	Q86TI2
HLLLGMGCNPMRGEE	FSCN3	241	Q9NQT6
CVKSRGRFPMMGIGQ	HUNK	656	P57058
VFTPNMICAGGEKGM	C1S	611	P09871
DQDAVGMLCMPKGLA	DENND5A	91	Q6IQ26
EGGDCATLMKNMGPL	MAST4	651	O15021
GMDGMKCGPGLRCQP	ESM1	71	Q9NQ30
RADGGVCKNGFVMQM	GK5	436	Q6ZS86
PLGLKDCIIVGGMDM	DDX49	96	Q9Y6V7
MPFSAGKRMCMGEGL	CYP2C18	426	P33260
CQMRNGMLLTGGGKD	EML4	516	Q9HC35
LAESAKRLGPGCGMM	ELP4	401	Q96EB1
GLMCQGPEKVRGMAI	FLRT1	326	Q9NZU1
KLGPVDMLVNCAGMA	KDSR	111	Q06136
AEMGCGPVDENLMEK	JADE3	156	Q92613
IPKGFMDGKQACERM	MYH10	736	P35580
EMGEKGEMGDKGCCG	OTOL1	231	A6NHN0
GCRKDMPVSEMAEDG	PRDM15	291	P57071
GGRMMNCPKILRQLG	SLAMF1	26	Q13291
PEMGMRLLCEGKNQN	SIGLECL1	76	Q8N7X8
VRKLMNCGGFGMEAT	SLC17A7	376	Q9P2U7
PDDRGMLDMCGFDTG	RO60	511	P10155
ENFCMGGPGVIMSRE	CHSY1	216	Q86X52
ENFCMGGPGMIFSRE	CHSY3	306	Q70JA7
MLPCAAGARGRGAMV	COA8	1	Q96IL0
MIGCGACEPKVKMAG	CNNM2	1	Q9H8M5
GGAMAAKPGELMGIC	C11orf96	311	Q7Z7L8
KRFMPMDNLSGGEKC	SMC1B	1116	Q8NDV3
CGRPRMLNRMVGGQD	PRSS27	26	Q9BQR3
VTEKMMCAGIPEGGV	TMPRSS4	366	Q9NRS4
GRCLMSSDGLPNKGM	TCF20	1161	Q9UGU0
LEAIGCQMEMGGGEN	RALGAPB	696	Q86X10
QMRRMGCPELQIGEA	TMEM209	361	Q96SK2
MLCPGRMDGAALGEQ	ZNF469	2701	Q96JG9
DGHLNLPVCKGMMEA	GTF3C1	1991	Q12789
GRMACQMGADRGPHV	TMEM169	146	Q96HH4
QGCPRKMAGEMAEGL	CX3CL1	366	P78423
TAVRKIMNCGGFGME	SLC17A8	386	Q8NDX2
MGLLRGGLPCARAMA	XXYLT1	1	Q8NBI6
RNGRCMVADEMGLGK	ZRANB3	51	Q5FWF4
KMAGGAARMEGNLPA	KCNJ3	476	P48549