Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.31e-22	114	51	15	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.69e-22	124	51	15	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.14e-21	137	51	15	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	ATG4A USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.51e-20	192	51	16	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	ATG4A USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.61e-12	654	51	16	GO:0008233
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-sulfur bonds	AHCYL1 AHCYL2	1.92e-05	3	51	2	GO:0046508
GeneOntologyMolecularFunction	adenosylhomocysteinase activity	AHCYL1 AHCYL2	1.92e-05	3	51	2	GO:0004013
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	KLHL9 TRIM51 KLHL13 RNF34 ZZEF1 TRIM49B TRIM48	3.05e-04	512	51	7	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	KLHL9 TRIM51 KLHL13 RNF34 ZZEF1 TRIM49B TRIM48	3.84e-04	532	51	7	GO:0016755
GeneOntologyMolecularFunction	microtubule motor activity	KIF21B KIF26A KIF26B	7.62e-04	70	51	3	GO:0003777
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	KLHL9 TRIM51 KLHL13 RNF34 TRIM49B TRIM48	1.25e-03	473	51	6	GO:0004842
GeneOntologyMolecularFunction	cullin family protein binding	KLHL9 KLHL13	2.00e-03	26	51	2	GO:0097602
GeneOntologyMolecularFunction	hyaluronic acid binding	USP17L24 USP17L6P	2.48e-03	29	51	2	GO:0005540
GeneOntologyMolecularFunction	acyltransferase activity	KLHL9 TRIM51 KLHL13 RNF34 ZZEF1 TRIM49B TRIM48	3.38e-03	775	51	7	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM51 RNF34 ZZEF1 TRIM49B TRIM48	3.40e-03	398	51	5	GO:0061659
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF21B KIF26A KIF26B	3.41e-03	118	51	3	GO:0003774
GeneOntologyMolecularFunction	mitogen-activated protein kinase binding	MAPKAPK3 PRKG1	3.61e-03	35	51	2	GO:0051019
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.33e-20	125	50	14	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.59e-19	144	50	14	GO:0070646
GeneOntologyBiologicalProcess	post-translational protein modification	ATG4A USP17L21 KLHL9 TRIM51 USP17L12 USP17L17 USP17L20 USP17L11 KLHL13 USP17L24 USP17L6P RNF34 USP17L5 USP17L10 USP17L19 USP17L22 ZZEF1 TRIM49B USP17L15 TRIM48 USP17L13 USP17L18	1.04e-15	1074	50	22	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L21 KLHL9 TRIM51 USP17L12 USP17L17 USP17L20 USP17L11 KLHL13 USP17L24 USP17L6P RNF34 USP17L5 USP17L10 USP17L19 USP17L22 ZZEF1 TRIM49B USP17L15 TRIM48 USP17L13 USP17L18	4.28e-15	1009	50	21	GO:0070647
GeneOntologyBiologicalProcess	S-adenosylmethionine cycle	AHCYL1 AHCYL2	1.20e-04	7	50	2	GO:0033353
GeneOntologyBiologicalProcess	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	USP17L24 USP17L6P	1.60e-04	8	50	2	GO:0071947
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L21 AHCYL1 DNAJC14 USP17L12 USP17L17 USP17L20 CYP4B1 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.82e-08	1293	51	16	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L21 AHCYL1 DNAJC14 USP17L12 USP17L17 USP17L20 CYP4B1 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.07e-08	1299	51	16	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L21 AHCYL1 DNAJC14 USP17L12 USP17L17 USP17L20 CYP4B1 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.48e-08	1327	51	16	GO:0042175
MousePheno	increased thymocyte apoptosis	RAP1GDS1 RIPK1 TWSG1	1.82e-05	27	27	3	MP:0009541
MousePheno	abnormal thymocyte apoptosis	RAP1GDS1 RIPK1 TWSG1	8.07e-05	44	27	3	MP:0009258
MousePheno	increased trophectoderm apoptosis	USP17L15 USP17L13	9.99e-05	8	27	2	MP:0012119
MousePheno	increased T cell apoptosis	RAP1GDS1 RIPK1 TWSG1	1.75e-04	57	27	3	MP:0006413
Domain	HABP4_PAI-RBP1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	1.38e-26	16	44	11	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	1.38e-26	16	44	11	IPR006861
Domain	USP_CS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	2.54e-20	66	44	12	IPR018200
Domain	USP_1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	5.46e-20	70	44	12	PS00972
Domain	UCH	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.56e-20	71	44	12	PF00443
Domain	USP_2	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.56e-20	71	44	12	PS00973
Domain	USP_3	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.86e-20	72	44	12	PS50235
Domain	USP_dom	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.86e-20	72	44	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.86e-20	72	44	12	IPR001394
Domain	S-Ado-L-homoCys_hydrolase_CS	AHCYL1 AHCYL2	1.62e-05	3	44	2	IPR020082
Domain	AdoHcyase_NAD	AHCYL1 AHCYL2	1.62e-05	3	44	2	SM00997
Domain	AdoHcyase	AHCYL1 AHCYL2	1.62e-05	3	44	2	SM00996
Domain	AdoHcyase	AHCYL1 AHCYL2	1.62e-05	3	44	2	PF05221
Domain	Adenosylhomocysteinase	AHCYL1 AHCYL2	1.62e-05	3	44	2	IPR000043
Domain	AdoHcyase_NAD	AHCYL1 AHCYL2	1.62e-05	3	44	2	PF00670
Domain	Ado_hCys_hydrolase_NAD-bd	AHCYL1 AHCYL2	1.62e-05	3	44	2	IPR015878
Domain	ADOHCYASE_1	AHCYL1 AHCYL2	1.62e-05	3	44	2	PS00738
Domain	ADOHCYASE_2	AHCYL1 AHCYL2	1.62e-05	3	44	2	PS00739
Domain	Kinesin-like_fam	KIF21B KIF26A KIF26B	1.41e-04	43	44	3	IPR027640
Domain	KINESIN_MOTOR_1	KIF21B KIF26A KIF26B	1.51e-04	44	44	3	PS00411
Domain	-	KIF21B KIF26A KIF26B	1.51e-04	44	44	3	3.40.850.10
Domain	Kinesin_motor_dom	KIF21B KIF26A KIF26B	1.51e-04	44	44	3	IPR001752
Domain	Kinesin	KIF21B KIF26A KIF26B	1.51e-04	44	44	3	PF00225
Domain	KISc	KIF21B KIF26A KIF26B	1.51e-04	44	44	3	SM00129
Domain	KINESIN_MOTOR_2	KIF21B KIF26A KIF26B	1.51e-04	44	44	3	PS50067
Domain	BBOX	TRIM51 TRIM49B TRIM48	5.73e-04	69	44	3	SM00336
Domain	Butyrophylin	TRIM51 TRIM49B TRIM48	5.98e-04	70	44	3	IPR003879
Domain	-	TRIM51 TRIM49B TRIM48	6.23e-04	71	44	3	4.10.45.10
Domain	zf-B_box	TRIM51 TRIM49B TRIM48	6.50e-04	72	44	3	PF00643
Domain	ZF_BBOX	TRIM51 TRIM49B TRIM48	8.83e-04	80	44	3	PS50119
Domain	Znf_B-box	TRIM51 TRIM49B TRIM48	9.16e-04	81	44	3	IPR000315
Domain	SPRY	TRIM51 TRIM49B TRIM48	1.41e-03	94	44	3	PF00622
Domain	SPRY_dom	TRIM51 TRIM49B TRIM48	1.41e-03	94	44	3	IPR003877
Domain	B30.2/SPRY	TRIM51 TRIM49B TRIM48	1.45e-03	95	44	3	IPR001870
Domain	B302_SPRY	TRIM51 TRIM49B TRIM48	1.45e-03	95	44	3	PS50188
Domain	-	KLHL9 KLHL13	1.83e-03	27	44	2	2.130.10.80
Domain	Gal_Oxidase_b-propeller	KLHL9 KLHL13	2.90e-03	34	44	2	IPR015916
Domain	BTB-kelch_protein	KLHL9 KLHL13	4.61e-03	43	44	2	IPR017096
Domain	ZF_RING_1	TRIM51 RNF34 TRIM49B TRIM48	4.80e-03	291	44	4	PS00518
Domain	ZF_RING_2	TRIM51 RNF34 TRIM49B TRIM48	5.22e-03	298	44	4	PS50089
Domain	RING	TRIM51 RNF34 TRIM49B TRIM48	5.66e-03	305	44	4	SM00184
Domain	Znf_RING	TRIM51 RNF34 TRIM49B TRIM48	7.14e-03	326	44	4	IPR001841
Domain	Kelch	KLHL9 KLHL13	8.25e-03	58	44	2	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KLHL9 KLHL13	8.52e-03	59	44	2	IPR011043
Domain	BACK	KLHL9 KLHL13	8.80e-03	60	44	2	SM00875
Domain	BACK	KLHL9 KLHL13	9.09e-03	61	44	2	PF07707
Domain	BACK	KLHL9 KLHL13	9.09e-03	61	44	2	IPR011705
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.05e-24	45	39	13	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 RIPK1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.87e-17	191	39	14	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 RIPK1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.82e-16	221	39	14	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 RIPK1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.13e-15	262	39	14	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 RIPK1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.58e-14	299	39	14	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 GFRA3 USP17L13 USP17L18	6.03e-14	318	39	14	MM15278
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 KLHL9 USP17L12 RIPK1 USP17L17 USP17L20 USP17L11 KLHL13 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.03e-07	1389	39	16	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 KLHL9 USP17L12 RIPK1 USP17L17 USP17L20 USP17L11 KLHL13 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	6.89e-07	1475	39	16	M19806
Pathway	KEGG_MEDICUS_REFERENCE_METHIONINE_DEGRADATION	AHCYL1 AHCYL2	3.31e-04	10	39	2	M47939
Pathway	REACTOME_KINESINS	KIF21B KIF26A KIF26B	5.17e-04	57	39	3	MM15714
Pathway	REACTOME_KINESINS	KIF21B KIF26A KIF26B	6.31e-04	61	39	3	M977
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.34e-33	21	52	13	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.34e-33	21	52	13	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.34e-33	21	52	13	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.34e-33	21	52	13	14583620
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.34e-33	21	52	13	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.34e-33	21	52	13	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.79e-32	22	52	13	9154835
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.28e-32	33	52	14	20228807
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	15780755
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	20403174
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	19188362
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	11941478
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	14699124
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.57e-32	34	52	14	21448158
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.98e-32	24	52	13	8995226
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	9.27e-32	35	52	14	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	9.27e-32	35	52	14	16611142
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.52e-31	36	52	14	20147298
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.87e-31	25	52	13	21115691
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.43e-31	37	52	14	20228808
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.73e-31	26	52	13	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.43e-30	29	52	13	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 PRAMEF14 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.69e-29	50	52	14	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 PRAMEF14 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.28e-13	674	52	14	37196079
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	5.41e-10	119	52	7	28625976
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM51 TRIM49B TRIM48	1.42e-06	15	52	3	19703589
Pubmed	Targeting Cul3-scaffold E3 ligase complex via KLHL substrate adaptors for cancer therapy.	KLHL9 KLHL13	6.57e-06	3	52	2	33872809
Pubmed	An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.	AHCYL1 AHCYL2	6.57e-06	3	52	2	19220705
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L15 USP17L13	1.31e-05	4	52	2	22984479
Pubmed	Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy.	RIPK1 RNF34	1.31e-05	4	52	2	32024692
Pubmed	p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.	RIPK1 MAPKAPK3	2.19e-05	5	52	2	28920954
Pubmed	Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.	KLHL9 KLHL13	2.19e-05	5	52	2	31515271
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF21B KIF26A KIF26B	2.36e-05	37	52	3	11416179
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	TRIM51 TRIM49B TRIM48	7.83e-05	55	52	3	19468303
Pubmed	Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.	AHCYL1 AHCYL2	7.84e-05	9	52	2	19224921
Pubmed	A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.	KLHL9 KLHL13	9.79e-05	10	52	2	17543862
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L6P USP17L15	9.79e-05	10	52	2	24207026
Pubmed	Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.	KLHL9 KLHL13	1.20e-04	11	52	2	14528312
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF21B KLHL9 KIF26A SPG11 POGZ ZZEF1	1.35e-04	529	52	6	14621295
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L6P USP17L15	1.43e-04	12	52	2	24695638
Pubmed	The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.	KLHL9 KLHL13	1.43e-04	12	52	2	19995937
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L6P USP17L15	1.97e-04	14	52	2	11793228
Pubmed	USP25 regulates Wnt signaling by controlling the stability of tankyrases.	KLHL9 KLHL13	2.60e-04	16	52	2	28619731
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM51 TRIM49B	3.69e-04	19	52	2	22144910
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L6P USP17L15	3.69e-04	19	52	2	28067227
Pubmed	A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.	KLHL9 KLHL13	5.44e-04	23	52	2	33130828
Pubmed	Dimerization quality control ensures neuronal development and survival.	KLHL9 KLHL13	5.93e-04	24	52	2	30190310
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TICRR USP17L12 KIF26B POLR2A TWSG1 ZZEF1	7.83e-04	736	52	6	29676528
Pubmed	A human MAP kinase interactome.	RAP1GDS1 RIPK1 KIF26A KIF26B POGZ	7.90e-04	486	52	5	20936779
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	5.29e-06	318	44	7	int:FLT3
Interaction	HEXIM2 interactions	AHCYL1 KLHL9 KLHL13 AHCYL2	3.05e-05	82	44	4	int:HEXIM2
Cytoband	4p16.1	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.56e-30	79	52	15	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.38e-23	222	52	15	chr4p16
Cytoband	11q11	TRIM51 TRIM48	1.32e-03	47	52	2	11q11
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF21B KIF26A KIF26B	4.32e-05	46	27	3	622
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM51 TRIM49B TRIM48	3.75e-04	95	27	3	59
GeneFamily	Ring finger proteins	TRIM51 RNF34 TRIM49B TRIM48	6.97e-04	275	27	4	58
GeneFamily	Kelch like\|BTB domain containing	KLHL9 KLHL13	1.78e-03	42	27	2	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL9 KLHL13	1.70e-02	134	27	2	861
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 KLHL13 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.70e-24	86	50	14	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.40e-20	112	50	13	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.91e-18	160	50	13	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.72e-10	647	50	13	MM981
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L21 AHCYL1 USP17L12 USP17L17 USP17L20 USP17L11 KLHL13 USP17L6P USP17L5 USP17L10 TWSG1 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.72e-10	1198	50	16	MM1062
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L21 AHCYL1 USP17L12 USP17L17 USP17L20 USP17L11 MAPKAPK3 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.98e-10	1072	50	15	MM1031
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 POLR2A USP17L6P USP17L5 USP17L10 AHCYL2 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.96e-09	1226	50	15	MM979
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF26B SCNN1B TWSG1 PRKG1 TMEM52B	9.28e-07	180	44	5	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma\|TCGA-Testes / Sample_Type by Project: Shred V9	TRIM51 PRAMEF14 TRIM49B TRIM48	1.08e-05	139	44	4	6b58d01ce9d9ac23434333f9faf1bb0eef14ba90
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1B TWSG1 PRKG1 TMEM52B	2.06e-05	164	44	4	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1B TWSG1 PRKG1 TMEM52B	3.37e-05	186	44	4	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL13 SCNN1B PRKG1 TMEM52B	3.59e-05	189	44	4	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIF26B KLHL13 PRKG1 TAFA4	3.82e-05	192	44	4	0003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1B TWSG1 PRKG1 TMEM52B	4.06e-05	195	44	4	3f517c6fc372bdcaf45b3af373414f13cbebd4ba
Drug	N6-hydroxyadenosine	AHCYL1 AHCYL2	7.70e-06	3	37	2	CID000018881
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.83e-29	46	47	14	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.15e-26	69	47	14	DOID:1682 (implicated_via_orthology)
Disease	serum metabolite measurement	RIPK1 KIF26B CYP4B1 MAPKAPK3 EXOC6B TRIM49B TRIM48	6.95e-04	945	47	7	EFO_0005653
Disease	internet addiction disorder	PRKG1 GFRA3	1.27e-03	33	47	2	EFO_0803368
Disease	macrophage colony stimulating factor measurement	AHCYL1 SCNN1B	1.60e-03	37	47	2	EFO_0008217
Disease	Pulmonary Hypertension	ATP7A PRKG1	1.86e-03	40	47	2	C0020542
Disease	Inherited neuropathies	ATP7A SPG11	1.86e-03	40	47	2	C0598589

Protein segments in the cluster

Peptide	Gene	Start	Entry
MSIHQCKISCESMGA	TWSG1	176	Q9GZX9
CGQMMLAQALICRHL	ATG4A	81	Q8WYN0
NMHVKEMHTCTVEGC	BNC1	741	Q01954
VVLKMKVEGMTCHSC	ATP7A	171	Q04656
AMNTMMCSRCQGKHR	DNAJC14	531	Q6Y2X3
NMHHGKRCLLIIMEC	MAPKAPK3	106	Q16644
SCTVHEMEAMKTICQ	ITPRID1	861	Q6ZRS4
CFQTIMMRTGLIKHT	PRKG1	196	Q13976
SRVNFCKAHLMMITC	KIF26B	2086	Q2KJY2
CLHQNMMRLACASTR	OR51H1	181	Q8NH63
HAIFTIHLCQMRMCT	KIF21B	226	O75037
KAPMTTVRGLHCMCT	KLHL9	476	Q9P2J3
VNLCKAHVMMVTCFD	KIF26A	1851	Q9ULI4
TACMSACKHLATSLM	EXOC6B	666	Q9Y2D4
MLRKALSTCASHFMV	OR12D1	226	P0DN82
MTTVRGLHCMCTVGE	KLHL13	521	Q9P2N7
SSLIGCMCHRRMKNQ	GFRA3	96	O60609
MVLICALMGSECLHK	RAP1GDS1	556	P52306
FCDVGHMALNTLMKC	CYP4B1	181	P13584
EKICNAHGCKMAMRL	SCNN1B	181	P51168
AHGCKMAMRLCSLNR	SCNN1B	186	P51168
QMSVAQRETCIGMCK	SCNN1B	431	P51168
MVCCKLMSASSQHLR	TAFA4	26	Q96LR4
EQMCGIHRETKKMFC	TRIM48	106	Q8IWZ4
LDRMKNSCIVCNMGH	AHCYL2	466	Q96HN2
RNCMSMGALKDLLCH	PRAMEF14	386	Q5SWL7
DRMKNSCIVCNMGHS	AHCYL1	386	O43865
HTACQRSKGMLVMDC	POGZ	1216	Q7Z3K3
VSLCFHRTQGLMIMK	RIPK1	31	Q13546
MSLKATNMQHCKCSI	C11orf40	151	Q8WZ69
EKHNMIALCFSMCRE	SPG11	2216	Q96JI7
MACCHKVMLLLDTAG	TICRR	1	Q7Z2Z1
GHMVTCTKCGKRMSE	RNF34	341	Q969K3
QICGMHRETKKMFCE	TRIM51	91	Q9BSJ1
LCDTMTCRGHLMAIT	POLR2A	1401	P24928
KGCMLCTMQAHITRA	USP17L18	121	D6R9N7
ALHMSRFTVAMCGQK	TMEM52B	141	Q4KMG9
KGCMLCTMQAHITRA	USP17L5	121	A8MUK1
KGCMLCTMQAHITRA	USP17L21	121	D6R901
KGCMLCTMQAHITRA	USP17L13	121	C9JLJ4
KGCMLCTMQAHITRA	USP17L19	121	D6RCP7
KGCMLCTMQAHITRA	USP17L12	121	C9JPN9
KGCMLCTMQAHITRA	USP17L24	121	Q0WX57
EHCNNMCTMRSSVLK	ZZEF1	206	O43149
QMCGTHRETKKMFCE	TRIM49B	91	A6NDI0
KGCMLCTMQAHITRA	USP17L6P	121	Q6QN14
KGCMLCTMQAHITRA	USP17L22	121	D6RA61
KGCMLCTMQAHITRA	USP17L15	121	C9J2P7
KGCMLCTMQAHITRA	USP17L17	121	D6RBQ6
KGCMLCTMQAHITRA	USP17L23	121	D6RBM5
KGCMLCTMQAHITRA	USP17L20	121	D6RJB6
KGCMLCTMQAHITRA	USP17L10	121	C9JJH3
CFRNICKQMTKMHEA	VPS54	886	Q9P1Q0
KGCMLCTMQAHITRA	USP17L11	121	C9JVI0