Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	co-SMAD binding	USP9Y USP9X	2.81e-04	12	42	2	GO:0070410
GeneOntologyMolecularFunction	small GTPase binding	DOCK5 SRGAP2 IPO7 SRGAP1 KIF3A	5.44e-04	321	42	5	GO:0031267
GeneOntologyMolecularFunction	SMAD binding	USP9Y IPO7 USP9X	7.84e-04	86	42	3	GO:0046332
GeneOntologyMolecularFunction	GTPase binding	DOCK5 SRGAP2 IPO7 SRGAP1 KIF3A	9.11e-04	360	42	5	GO:0051020
GeneOntologyMolecularFunction	protein phosphatase binding	MTMR4 KIF3A PPP1CA PPP1CC	9.73e-04	210	42	4	GO:0019903
GeneOntologyCellularComponent	PTW/PP1 phosphatase complex	PPP1CA PPP1CC	8.22e-05	7	42	2	GO:0072357
Domain	STPPase_N	PPP1CA PPP1CC	1.41e-05	3	41	2	PF16891
Domain	STPPase_N	PPP1CA PPP1CC	1.41e-05	3	41	2	IPR031675
Domain	FCH	SRGAP2 SRGAP3 SRGAP1	1.47e-05	22	41	3	PF00611
Domain	FCH	SRGAP2 SRGAP3 SRGAP1	1.47e-05	22	41	3	SM00055
Domain	FCH_dom	SRGAP2 SRGAP3 SRGAP1	1.69e-05	23	41	3	IPR001060
Domain	F_BAR	SRGAP2 SRGAP3 SRGAP1	2.18e-05	25	41	3	IPR031160
Domain	F_BAR	SRGAP2 SRGAP3 SRGAP1	2.18e-05	25	41	3	PS51741
Domain	FAD_binding_3	MICAL3 MICAL2	7.01e-05	6	41	2	PF01494
Domain	FAD-bd	MICAL3 MICAL2	7.01e-05	6	41	2	IPR002938
Domain	RhoGAP	SRGAP2 SRGAP3 SRGAP1	3.39e-04	62	41	3	SM00324
Domain	RhoGAP	SRGAP2 SRGAP3 SRGAP1	3.56e-04	63	41	3	PF00620
Domain	Ser/Thr-sp_prot-phosphatase	PPP1CA PPP1CC	3.61e-04	13	41	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP1CA PPP1CC	3.61e-04	13	41	2	PS00125
Domain	PP2Ac	PPP1CA PPP1CC	3.61e-04	13	41	2	SM00156
Domain	RHOGAP	SRGAP2 SRGAP3 SRGAP1	3.73e-04	64	41	3	PS50238
Domain	RhoGAP_dom	SRGAP2 SRGAP3 SRGAP1	3.73e-04	64	41	3	IPR000198
Domain	-	SRGAP2 SRGAP3 SRGAP1	3.73e-04	64	41	3	1.10.555.10
Domain	SH3_1	DOCK5 SRGAP2 SRGAP3 SRGAP1	4.51e-04	164	41	4	PF00018
Domain	Rho_GTPase_activation_prot	SRGAP2 SRGAP3 SRGAP1	9.47e-04	88	41	3	IPR008936
Domain	SH3	DOCK5 SRGAP2 SRGAP3 SRGAP1	1.26e-03	216	41	4	PS50002
Domain	SH3	DOCK5 SRGAP2 SRGAP3 SRGAP1	1.26e-03	216	41	4	SM00326
Domain	SH3_domain	DOCK5 SRGAP2 SRGAP3 SRGAP1	1.35e-03	220	41	4	IPR001452
Domain	Calcineurin-like_PHP_ApaH	PPP1CA PPP1CC	1.71e-03	28	41	2	IPR004843
Domain	Metallophos	PPP1CA PPP1CC	1.71e-03	28	41	2	PF00149
Domain	Metallo-depent_PP-like	PPP1CA PPP1CC	1.97e-03	30	41	2	IPR029052
Domain	-	PPP1CA PPP1CC	1.97e-03	30	41	2	3.60.21.10
Domain	ARM-type_fold	DOCK5 USP9Y IPO7 USP9X	6.36e-03	339	41	4	IPR016024
Domain	-	MICAL3 MICAL2	6.72e-03	56	41	2	3.50.50.60
Domain	FAD/NAD-binding_dom	MICAL3 MICAL2	6.95e-03	57	41	2	IPR023753
Domain	CH	MICAL3 MICAL2	8.96e-03	65	41	2	SM00033
Domain	USP_CS	USP9Y USP9X	9.23e-03	66	41	2	IPR018200
Domain	LIM	MICAL3 MICAL2	1.01e-02	69	41	2	PF00412
Domain	-	MICAL3 MICAL2	1.03e-02	70	41	2	2.10.110.10
Domain	CH	MICAL3 MICAL2	1.03e-02	70	41	2	PF00307
Domain	USP_1	USP9Y USP9X	1.03e-02	70	41	2	PS00972
Domain	LIM_DOMAIN_2	MICAL3 MICAL2	1.06e-02	71	41	2	PS50023
Domain	Znf_LIM	MICAL3 MICAL2	1.06e-02	71	41	2	IPR001781
Domain	LIM_DOMAIN_1	MICAL3 MICAL2	1.06e-02	71	41	2	PS00478
Domain	-	MICAL3 MICAL2	1.06e-02	71	41	2	1.10.418.10
Domain	UCH	USP9Y USP9X	1.06e-02	71	41	2	PF00443
Domain	LIM	MICAL3 MICAL2	1.06e-02	71	41	2	SM00132
Domain	USP_2	USP9Y USP9X	1.06e-02	71	41	2	PS00973
Domain	USP_3	USP9Y USP9X	1.09e-02	72	41	2	PS50235
Domain	USP_dom	USP9Y USP9X	1.09e-02	72	41	2	IPR028889
Pathway	REACTOME_INACTIVATION_OF_CDC42_AND_RAC1	SRGAP2 SRGAP3 SRGAP1	8.49e-07	8	36	3	M27349
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	MYF5 MTMR4 ACVR2A USP9X PPP1CA PPP1CC	2.97e-06	161	36	6	M27871
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	MTMR4 PPP1CA PPP1CC	3.82e-05	26	36	3	M628
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	MTMR4 USP9X PPP1CA PPP1CC	9.27e-05	94	36	4	M1041
Pathway	WP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION	CAMK2A PPP1CA PPP1CC	1.53e-04	41	36	3	M39655
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	PPP1CA PPP1CC	1.76e-04	8	36	2	M47933
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	MTMR4 PPP1CA PPP1CC	2.30e-04	47	36	3	M646
Pathway	KEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX	PPP1CA PPP1CC	4.12e-04	12	36	2	M47887
Pathway	KEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE	PPP1CA PPP1CC	4.12e-04	12	36	2	M47891
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION	PPP1CA PPP1CC	7.44e-04	16	36	2	M48235
Pathway	KEGG_LONG_TERM_POTENTIATION	CAMK2A PPP1CA PPP1CC	7.44e-04	70	36	3	M3115
Pathway	REACTOME_RHO_GTPASE_CYCLE	DOCK5 SRGAP2 DSG1 SRGAP3 USP9X SRGAP1	7.76e-04	439	36	6	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	DOCK5 SRGAP2 DSG1 SRGAP3 USP9X SRGAP1	8.83e-04	450	36	6	M27078
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK5 SRGAP2 SRGAP3 SRGAP1	9.91e-04	175	36	4	MM15599
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	DOCK5 SRGAP2 DSG1 SRGAP3 USP9X SRGAP1 PPP1CC	1.10e-03	649	36	7	MM15690
Pathway	REACTOME_ONCOGENIC_MAPK_SIGNALING	TENT4A CAMK2A PPP1CC	1.18e-03	82	36	3	M27626
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK5 SRGAP2 SRGAP3 SRGAP1	1.19e-03	184	36	4	M41809
Pathway	REACTOME_TRIGLYCERIDE_CATABOLISM	PPP1CA PPP1CC	1.69e-03	24	36	2	M10064
Pathway	REACTOME_CDC42_GTPASE_CYCLE	SRGAP2 SRGAP3 SRGAP1	1.75e-03	94	36	3	MM15598
Pathway	PID_ALK1_PATHWAY	ACVR2A PPP1CA	1.98e-03	26	36	2	M185
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	DOCK5 SRGAP2 DSG1 SRGAP3 USP9X SRGAP1 PPP1CC	2.01e-03	720	36	7	M41838
Pubmed	Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.	SRGAP2 SRGAP3 SRGAP1	1.64e-09	3	42	3	19137586
Pubmed	SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.	SRGAP2 SRGAP3 SRGAP1	3.27e-08	6	42	3	33514561
Pubmed	FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.	SRGAP2 SRGAP3 SRGAP1	3.27e-08	6	42	3	12736724
Pubmed	Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.	SRGAP2 SRGAP3 SRGAP1	3.27e-08	6	42	3	11672528
Pubmed	Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.	SRGAP2 SRGAP3 SRGAP1	5.71e-08	7	42	3	21655271
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MICAL3 SRGAP2 SF3B3 DNAH6 MICAL2 SRGAP3 CAMK2A USP9X KIF3A PPP1CA PPP1CC	7.27e-07	1431	42	11	37142655
Pubmed	Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.	USP9X PPP1CA PPP1CC	9.07e-07	16	42	3	36484700
Pubmed	Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.	SRGAP2 SRGAP1	1.42e-06	2	42	2	33984363
Pubmed	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.	SRGAP2 SRGAP3	1.42e-06	2	42	2	23505444
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9Y USP9X	1.42e-06	2	42	2	8922996
Pubmed	Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.	PPP1CA PPP1CC	1.42e-06	2	42	2	9882500
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9Y USP9X	1.42e-06	2	42	2	12925892
Pubmed	PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.	PPP1CA PPP1CC	1.42e-06	2	42	2	23176181
Pubmed	Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.	SRGAP3 SRGAP1	1.42e-06	2	42	2	22271578
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9Y USP9X	1.42e-06	2	42	2	12895410
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MICAL3 USP9Y DDX24 ME1 USP9X PPP1CA RBM26	2.04e-06	497	42	7	36774506
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	S100A4 SF3B3 IPO7 PPP1CA PPP1CC	2.11e-06	173	42	5	31470122
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	SRGAP2 FBN2 SRGAP3 USP9X SRGAP1	3.98e-06	197	42	5	17500595
Pubmed	The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.	PPP1CA PPP1CC	4.27e-06	3	42	2	12138106
Pubmed	Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.	PPP1CA PPP1CC	4.27e-06	3	42	2	7857673
Pubmed	Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.	PPP1CA PPP1CC	4.27e-06	3	42	2	11739654
Pubmed	Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.	PPP1CA PPP1CC	4.27e-06	3	42	2	19074462
Pubmed	Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.	PPP1CA PPP1CC	4.27e-06	3	42	2	11588169
Pubmed	1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.	PPP1CA PPP1CC	4.27e-06	3	42	2	25073485
Pubmed	Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.	PPP1CA PPP1CC	4.27e-06	3	42	2	21712997
Pubmed	NOM1 targets protein phosphatase I to the nucleolus.	PPP1CA PPP1CC	4.27e-06	3	42	2	17965019
Pubmed	Characterization of protein phosphatases in mouse oocytes.	PPP1CA PPP1CC	4.27e-06	3	42	2	9882488
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	MICAL3 SRGAP2 IRS4 SF3B3 IPO7 ME1 USP9X PPP1CA RBM26	7.58e-06	1149	42	9	35446349
Pubmed	Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.	MICAL3 MICAL2	8.53e-06	4	42	2	24440334
Pubmed	Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.	PPP1CA PPP1CC	8.53e-06	4	42	2	23499489
Pubmed	Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.	PPP1CA PPP1CC	8.53e-06	4	42	2	16131488
Pubmed	Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.	PPP1CA PPP1CC	8.53e-06	4	42	2	10194355
Pubmed	The MICAL proteins and rab1: a possible link to the cytoskeleton?	MICAL3 MICAL2	8.53e-06	4	42	2	15694364
Pubmed	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.	PPP1CA PPP1CC	8.53e-06	4	42	2	23277204
Pubmed	NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.	PPP1CA PPP1CC	8.53e-06	4	42	2	10880350
Pubmed	The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.	PPP1CA PPP1CC	8.53e-06	4	42	2	12016225
Pubmed	Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.	PPP1CA PPP1CC	8.53e-06	4	42	2	12221103
Pubmed	Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.	PPP1CA PPP1CC	8.53e-06	4	42	2	15226296
Pubmed	Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.	PPP1CA PPP1CC	8.53e-06	4	42	2	22768081
Pubmed	Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.	PPP1CA PPP1CC	8.53e-06	4	42	2	12226088
Pubmed	Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.	PPP1CA PPP1CC	8.53e-06	4	42	2	17202132
Pubmed	Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.	PPP1CA PPP1CC	8.53e-06	4	42	2	10807923
Pubmed	A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.	PPP1CA PPP1CC	8.53e-06	4	42	2	12036952
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	PPP1CA PPP1CC	8.53e-06	4	42	2	12410313
Pubmed	Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.	PPP1CA PPP1CC	8.53e-06	4	42	2	24902662
Pubmed	Nuclear protein phosphatase-1 regulates HIV-1 transcription.	PPP1CA PPP1CC	8.53e-06	4	42	2	12788939
Pubmed	IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation.	MYF5 IRS4	8.53e-06	4	42	2	28821740
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	SF3B3 USP9Y TIA1 USP9X PPP1CC	1.12e-05	244	42	5	29884807
Pubmed	SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.	PPP1CA PPP1CC	1.42e-05	5	42	2	20424263
Pubmed	Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.	PPP1CA PPP1CC	1.42e-05	5	42	2	23197154
Pubmed	Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.	PPP1CA PPP1CC	1.42e-05	5	42	2	12624094
Pubmed	Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.	PPP1CA PPP1CC	1.42e-05	5	42	2	19581931
Pubmed	The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.	PPP1CA PPP1CC	1.42e-05	5	42	2	12016208
Pubmed	Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.	PPP1CA PPP1CC	1.42e-05	5	42	2	22801782
Pubmed	MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.	MICAL3 MICAL2	1.42e-05	5	42	2	12110185
Pubmed	Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.	PPP1CA PPP1CC	1.42e-05	5	42	2	11551964
Pubmed	The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.	PPP1CA PPP1CC	1.42e-05	5	42	2	28615442
Pubmed	Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.	PPP1CA PPP1CC	1.42e-05	5	42	2	10209101
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	PPP1CA PPP1CC	1.42e-05	5	42	2	17511879
Pubmed	A PP1-PP2A phosphatase relay controls mitotic progression.	PPP1CA PPP1CC	1.42e-05	5	42	2	25487150
Pubmed	The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.	PPP1CA PPP1CC	1.42e-05	5	42	2	24116158
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	EXO1 IRS4 SF3B3 IPO7 TIA1 DSG1 USP9X PPP1CA PPP1CC	1.55e-05	1257	42	9	37317656
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	DSG1 CAMK2A PPP1CA PPP1CC	1.93e-05	131	42	4	28634551
Pubmed	Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).	PPP1CA PPP1CC	2.13e-05	6	42	2	25785436
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1CA PPP1CC	2.13e-05	6	42	2	21998301
Pubmed	Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.	PPP1CA PPP1CC	2.13e-05	6	42	2	23088536
Pubmed	Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.	PPP1CA PPP1CC	2.13e-05	6	42	2	18641122
Pubmed	SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.	PPP1CA PPP1CC	2.13e-05	6	42	2	14640981
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SRGAP2 SRGAP3 CAMK2A USP9X PPP1CA	2.21e-05	281	42	5	28706196
Pubmed	Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.	PPP1CA PPP1CC	2.98e-05	7	42	2	18689497
Pubmed	NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.	EXO1 PPP1CA	2.98e-05	7	42	2	28216226
Pubmed	SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.	PPP1CA PPP1CC	2.98e-05	7	42	2	17123353
Pubmed	Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.	PPP1CA PPP1CC	2.98e-05	7	42	2	33537097
Pubmed	A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.	PPP1CA PPP1CC	2.98e-05	7	42	2	12147701
Pubmed	Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.	PPP1CA PPP1CC	2.98e-05	7	42	2	10637318
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	SRGAP2 SRGAP3 SRGAP1	3.09e-05	50	42	3	19807924
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MICAL3 MTMR4 IRS4 IPO7 ME1 USP9X PPP1CA PPP1CC	3.16e-05	1049	42	8	27880917
Pubmed	A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.	PPP1CA PPP1CC	3.97e-05	8	42	2	12036313
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP1CA PPP1CC	3.97e-05	8	42	2	16262633
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	PPP1CA PPP1CC	3.97e-05	8	42	2	21930935
Pubmed	RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.	PPP1CA PPP1CC	5.10e-05	9	42	2	20926688
Pubmed	Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.	PPP1CA PPP1CC	5.10e-05	9	42	2	21566083
Pubmed	Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.	CAMK2A PPP1CC	6.37e-05	10	42	2	20124353
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9Y USP9X	6.37e-05	10	42	2	9384609
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	IRS4 SF3B3 IPO7 DSG1 PPP1CC	6.90e-05	357	42	5	37059091
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EXO1 SRGAP2 MTMR4 IRS4 CAMK2A SRGAP1 PPP1CA	7.05e-05	861	42	7	36931259
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	MICAL3 SRGAP2 CAMK2A	7.43e-05	67	42	3	29254152
Pubmed	USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.	IRS4 USP9X	7.78e-05	11	42	2	33558705
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	CAMK2A PPP1CA	7.78e-05	11	42	2	39256359
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9Y USP9X	9.32e-05	12	42	2	23861879
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PPP1CA PPP1CC	9.32e-05	12	42	2	10830164
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SF3B3 IPO7 DDX24 ME1 MICAL2 KIF3A PPP1CA PPP1CC	1.06e-04	1247	42	8	27684187
Pubmed	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.	SPOP KIF3A	1.10e-04	13	42	2	19684112
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	S100A4 SRGAP2 IRS4 DSG1 DDX24 USP9X	1.12e-04	639	42	6	23443559
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IRS4 IPO7 DDX24 USP9X PPP1CA PPP1CC	1.26e-04	653	42	6	22586326
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP1CA PPP1CC	1.28e-04	14	42	2	16048649
Pubmed	Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains.	HOXA11 MYF5	1.28e-04	14	42	2	20412779
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	IRS4 SF3B3 USP9X PPP1CA PPP1CC	1.34e-04	411	42	5	36652389
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	IRS4 IPO7 DDX24 USP9X	1.37e-04	217	42	4	31685992
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SRGAP2 SRGAP3 CAMK2A USP9X KIF3A PPP1CA PPP1CC	1.41e-04	963	42	7	28671696
Interaction	YWHAZ interactions	EXO1 SRGAP2 SPOP MTMR4 IRS4 PDE6C IPO7 DDX24 SRGAP3 CAMK2A SRGAP1 PPP1CA PPP1CC RBM26	1.63e-07	1319	41	14	int:YWHAZ
Interaction	PKP3 interactions	MTMR4 DSG1 DDX24 KIF3A PPP1CC	8.01e-06	136	41	5	int:PKP3
Interaction	DYNLT4 interactions	ACVR2A PPP1CA PPP1CC	8.70e-06	20	41	3	int:DYNLT4
Interaction	PTEN interactions	SPOP IRS4 FBN2 SF3B3 IPO7 DSG1 DDX24 USP9X SRGAP1 PPP1CA	1.26e-05	929	41	10	int:PTEN
Interaction	PPP1R2C interactions	PPP1CA PPP1CC	2.42e-05	4	41	2	int:PPP1R2C
Interaction	YWHAB interactions	EXO1 SRGAP2 MTMR4 IRS4 PDE6C DDX24 CAMK2A SRGAP1 PPP1CA PPP1CC	2.68e-05	1014	41	10	int:YWHAB
Interaction	HTRA4 interactions	S100A4 SF3B3 IPO7 PPP1CA PPP1CC	3.36e-05	183	41	5	int:HTRA4
Interaction	CSRNP2 interactions	PPP1CA PPP1CC	4.02e-05	5	41	2	int:CSRNP2
Interaction	BAP1 interactions	EXO1 MICAL3 SRGAP2 IRS4 SF3B3 IPO7 ME1 CAMK2A USP9X PPP1CA RBM26	4.45e-05	1314	41	11	int:BAP1
Interaction	PPP1R14B interactions	USP9X PPP1CA PPP1CC	4.48e-05	34	41	3	int:PPP1R14B
Interaction	RALBP1 interactions	SRGAP2 ACVR2A DSG1 DNAH6 SRGAP1	4.89e-05	198	41	5	int:RALBP1
Interaction	SPOPL interactions	SRGAP2 SPOP SRGAP1	5.79e-05	37	41	3	int:SPOPL
Interaction	SFRP5 interactions	PPP1CA PPP1CC	6.03e-05	6	41	2	int:SFRP5
Interaction	YWHAQ interactions	EXO1 SRGAP2 SPOP MTMR4 IRS4 PDE6C DDX24 CAMK2A SRGAP1 PPP1CA	6.14e-05	1118	41	10	int:YWHAQ
Interaction	PPP1R15A interactions	KIF3A PPP1CA PPP1CC	7.33e-05	40	41	3	int:PPP1R15A
Interaction	SORBS2 interactions	SRGAP2 SRGAP1 PPP1CA PPP1CC	7.54e-05	111	41	4	int:SORBS2
Interaction	KCTD13 interactions	MICAL3 SRGAP2 SF3B3 DNAH6 MICAL2 SRGAP3 CAMK2A USP9X KIF3A PPP1CA PPP1CC	7.62e-05	1394	41	11	int:KCTD13
Interaction	FBXO22 interactions	MICAL3 USP9Y DDX24 ME1 USP9X PPP1CA RBM26	9.72e-05	540	41	7	int:FBXO22
Interaction	MAPK1 interactions	SPOP MTMR4 TIA1 ME1 PPP1CA CUEDC1 PPP1CC	1.01e-04	543	41	7	int:MAPK1
Interaction	NEK2 interactions	SF3B3 DSG1 PPP1CA PPP1CC	1.27e-04	127	41	4	int:NEK2
Interaction	CORO1A interactions	TIA1 DDX24 PPP1CA PPP1CC	1.95e-04	142	41	4	int:CORO1A
Interaction	EIF2A interactions	SPOP SF3B3 PPP1CA PPP1CC	2.06e-04	144	41	4	int:EIF2A
Interaction	RPRD2 interactions	S100A4 SPOP PPP1CA PPP1CC	2.17e-04	146	41	4	int:RPRD2
Interaction	LHX5 interactions	SRGAP2 SRGAP1	2.20e-04	11	41	2	int:LHX5
Interaction	RAC1 interactions	DOCK5 MICAL3 SRGAP2 IRS4 IPO7 SRGAP3 USP9X SRGAP1 PPP1CC	2.32e-04	1063	41	9	int:RAC1
Interaction	ARHGAP15 interactions	SRGAP2 MICAL2 SRGAP1	2.35e-04	59	41	3	int:ARHGAP15
Interaction	PRICKLE1 interactions	SRGAP2 USP9X SRGAP1	2.47e-04	60	41	3	int:PRICKLE1
Interaction	PPP1R1B interactions	PPP1CA PPP1CC	2.63e-04	12	41	2	int:PPP1R1B
Interaction	PRICKLE2 interactions	SRGAP2 USP9X SRGAP1	2.72e-04	62	41	3	int:PRICKLE2
Interaction	RAPH1 interactions	SRGAP3 SRGAP1 PPP1CC	2.99e-04	64	41	3	int:RAPH1
Interaction	RAD18 interactions	IPO7 SRGAP3 SRGAP1 PPP1CA PPP1CC RBM26	3.02e-04	457	41	6	int:RAD18
Interaction	SLC26A7 interactions	SRGAP2 SRGAP1	3.11e-04	13	41	2	int:SLC26A7
Interaction	PHACTR1 interactions	TIA1 PPP1CA	3.62e-04	14	41	2	int:PHACTR1
Interaction	PPP1R2B interactions	PPP1CA PPP1CC	3.62e-04	14	41	2	int:PPP1R2B
Interaction	CSNK1E interactions	MTMR4 USP9Y USP9X PPP1CA PPP1CC	4.03e-04	311	41	5	int:CSNK1E
Interaction	AURKA interactions	SPOP MTMR4 IRS4 FBN2 USP9X PPP1CA PPP1CC	4.59e-04	696	41	7	int:AURKA
Interaction	MYO16 interactions	PPP1CA PPP1CC	4.76e-04	16	41	2	int:MYO16
Interaction	PRR16 interactions	PPP1CA PPP1CC	4.76e-04	16	41	2	int:PRR16
Interaction	FZR1 interactions	SPOP IRS4 ZBTB8OS SF3B3 DDX24 CAMK2A USP9X PPP1CA RBM26	4.77e-04	1172	41	9	int:FZR1
Interaction	DLGAP1 interactions	CAMK2A USP9X PPP1CA PPP1CC	4.82e-04	180	41	4	int:DLGAP1
Interaction	KIFBP interactions	USP9X KIF3A PPP1CA PPP1CC	4.82e-04	180	41	4	int:KIFBP
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2 SRGAP3 SRGAP1	7.90e-06	23	31	3	1288
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SRGAP2 SRGAP3 SRGAP1	8.47e-05	50	31	3	721
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP1CA PPP1CC	2.19e-04	13	31	2	693
GeneFamily	Ubiquitin specific peptidases	USP9Y USP9X	4.14e-03	56	31	2	366
GeneFamily	LIM domain containing	MICAL3 MICAL2	4.58e-03	59	31	2	1218
Coexpression	GSE45365_NK_CELL_VS_CD8A_DC_UP	CLEC1B FAM3B MTMR4 SF3B3 DSG1	1.47e-05	200	41	5	M10028
Disease	focal segmental glomerulosclerosis (implicated_via_orthology)	LIPC SRGAP1	3.75e-05	7	40	2	DOID:1312 (implicated_via_orthology)
Disease	severe acute respiratory syndrome, COVID-19	NLN SRGAP2 SRGAP3 USP9X RBM26	3.32e-04	447	40	5	EFO_0000694, MONDO_0100096
Disease	type 2 diabetes mellitus (implicated_via_orthology)	IRS4 PPP1CA PPP1CC	3.93e-04	105	40	3	DOID:9352 (implicated_via_orthology)
Disease	age at menopause	EXO1 IPO7 TENT4A RBM26	7.35e-04	302	40	4	EFO_0004704
Disease	cholesteryl ester 22:6 measurement	SRGAP2 SRGAP3	8.66e-04	32	40	2	EFO_0010350
Disease	cysteine-rich with EGF-like domain protein 1 measurement	SRGAP2 SRGAP3	8.66e-04	32	40	2	EFO_0021870
Disease	skin microbiome measurement	SRGAP2 SRGAP3	1.29e-03	39	40	2	EFO_0801228
Disease	triglycerides to total lipids in medium LDL percentage	LIPC TENT4A	2.11e-03	50	40	2	EFO_0022334
Disease	triglycerides to total lipids in large LDL percentage	LIPC TENT4A	2.19e-03	51	40	2	EFO_0022331
Disease	free cholesterol to total lipids in small HDL percentage	LIPC TENT4A	2.19e-03	51	40	2	EFO_0022285
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	LIPC TENT4A	2.19e-03	51	40	2	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	uterine fibroid	DOCK5 NLN MTMR4	2.48e-03	199	40	3	EFO_0000731
Disease	cholesterol to total lipids in large LDL percentage	LIPC TENT4A	2.63e-03	56	40	2	EFO_0022235

Protein segments in the cluster

Peptide	Gene	Start	Entry
EAFEQCAMAMFGYMT	ZBTB8OS	51	Q8IWT0
EGNMCNEKFSYFPEM	ACVR2A	106	P27037
DYDEKGFCMRGDMCP	RBM26	296	Q5T8P6
MDVMDGCQFSPSEYF	MYF5	1	P13349
YGQPDVAMFDFTCMY	MICAL3	361	Q7RTP6
DEFMEAVSSKYGMNC	ME1	226	P48163
MTFVQFANDECDYGM	nan	276	A8MVJ9
SEMDYESMPSFQFCV	FAT2	1826	Q9NYQ8
VFQQDGFDYFTDMMP	IPO7	681	O95373
APECGMQMFFYVTLA	OR2T4	126	Q8NH00
YVAENGFICNMMNAP	PDE6C	351	P51160
GFICNMMNAPADEYF	PDE6C	356	P51160
MMNAPADEYFTFQKG	PDE6C	361	P51160
EFNQAMDDFKTMFPN	CUEDC1	46	Q9NWM3
QSMAYPCGDMNSFSQ	LIPC	296	P11150
MDFDERGPCSSNMYL	HOXA11	1	P31270
TMMCANIGPADYNYD	KIF3A	316	Q9Y496
CFDMYEGDNSGPMTK	FAM3B	126	P58499
EGGLNMNFMESYFCQ	DSG1	686	Q02413
EYYPNCEVVFMGMAN	MTMR4	331	Q9NYA4
DFYNFMSPCPEEAAM	TENT4A	226	Q5XG87
NYCGEFDNAGAMMSV	PPP1CA	271	P62136
FNCSDGLDYKMMGRF	DNAH6	1496	Q9C0G6
PIFFDMMQCEFNFSG	DOCK5	1126	Q9H7D0
PNMFADGQMDDLVCF	DDX24	36	Q9GZR7
ECFEGYESGFMMMKN	FBN2	1141	P35556
YGQPDVAMFDFTCMY	MICAL2	361	O94851
KDNDSESDYMFMAPG	IRS4	771	O14654
MKNQCFGGEYMGEVF	USP9X	1916	Q93008
DENMMDPYNLAICFG	SRGAP1	646	Q7Z6B7
CIAMMCNEFFEGFPD	S100A4	81	P26447
FQCPYMKTEDGFEMQ	RDH14	146	Q9HBH5
FESYTKMCDPGMTAF	CAMK2A	366	Q9UQM7
PTDRYVGFCMKFVNM	EXO1	51	Q9UQ84
SCNPEMMKNAADSYF	BROX	51	Q5VW32
NMFEFLEDGKGNMNC	CLEC1B	181	Q9P126
MFYSCFKKEGIMNPE	NLN	646	Q9BYT8
CMVSDFFYPNMGGVE	PIGA	36	P37287
DENMMDPYNLAICFG	SRGAP3	646	O43295
FKEMMCFIYTGKAPN	SPOP	251	O43791
EENMMDPYNLAICFG	SRGAP2	631	O75044
EEMKNQCFGGEYMGE	USP9Y	1916	O00507
NYCGEFDNAGAMMSV	PPP1CC	271	P36873
GFENPMFACLEMDYE	SF3B3	176	Q15393
CKMIMDTAGNDPYCF	TIA1	36	P31483