Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	CPEB2 CPEB3 CPEB4	8.85e-05	17	104	3	GO:0000900
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic translation	CPEB2 CPEB3 CPEB4	1.41e-05	10	103	3	GO:2000766
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	SLITRK5 SYT4	2.47e-05	2	103	2	GO:0150035
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic translational elongation	CPEB2 CPEB3	2.47e-05	2	103	2	GO:1900248
GeneOntologyBiologicalProcess	regulation of cytoplasmic translation	CPEB2 CPEB3 PAIP1 CPEB4	3.41e-05	37	103	4	GO:2000765
GeneOntologyBiologicalProcess	regulation of cytoplasmic translational elongation	CPEB2 CPEB3	7.38e-05	3	103	2	GO:1900247
GeneOntologyCellularComponent	multivesicular body lumen	PGA4 PGA5 PGA3	4.13e-06	7	104	3	GO:0097486
GeneOntologyCellularComponent	late endosome lumen	PGA4 PGA5 PGA3	1.92e-05	11	104	3	GO:0031906
GeneOntologyCellularComponent	upper tip-link density	MYO7A USH1C	2.45e-05	2	104	2	GO:1990435
GeneOntologyCellularComponent	stereocilia tip-link density	MYO7A USH1C	7.33e-05	3	104	2	GO:1990427
GeneOntologyCellularComponent	stereocilia tip link	MYO7A USH1C	7.33e-05	3	104	2	GO:0002140
GeneOntologyCellularComponent	9+0 non-motile cilium	MYO7A RCVRN PPEF2 USH1C PKHD1 IFT80	1.17e-04	153	104	6	GO:0097731
GeneOntologyCellularComponent	non-motile cilium	MYO7A RCVRN PPEF2 USH1C PKHD1 IFT80	4.46e-04	196	104	6	GO:0097730
GeneOntologyCellularComponent	photoreceptor inner segment	MYO7A RCVRN PPEF2 USH1C	6.22e-04	78	104	4	GO:0001917
GeneOntologyCellularComponent	stereocilia coupling link	MYO7A USH1C	6.73e-04	8	104	2	GO:0002139
GeneOntologyCellularComponent	endosome lumen	PGA4 PGA5 PGA3	1.28e-03	43	104	3	GO:0031904
Domain	CEBP_ZZ	CPEB2 CPEB3 CPEB4	6.12e-07	4	101	3	IPR032296
Domain	CEBP_ZZ	CPEB2 CPEB3 CPEB4	6.12e-07	4	101	3	PF16366
Domain	RRM_7	CPEB2 CPEB3 CPEB4	6.12e-07	4	101	3	PF16367
Domain	Aspartic_peptidase_N	PGA4 PGA5 PGA3	5.29e-06	7	101	3	IPR012848
Domain	A1_Propeptide	PGA4 PGA5 PGA3	5.29e-06	7	101	3	PF07966
Domain	Aspartic_peptidase_A1	PGA4 PGA5 PGA3	1.79e-05	10	101	3	IPR001461
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	1.79e-05	10	101	3	IPR033121
Domain	Asp	PGA4 PGA5 PGA3	1.79e-05	10	101	3	PF00026
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	1.79e-05	10	101	3	PS51767
Domain	-	PGA4 PGA5 PGA3	3.26e-05	12	101	3	2.40.70.10
Domain	ASP_PROTEASE	PGA4 PGA5 PGA3	3.26e-05	12	101	3	PS00141
Domain	Aspartic_peptidase_AS	PGA4 PGA5 PGA3	4.22e-05	13	101	3	IPR001969
Domain	Peptidase_aspartic_dom	PGA4 PGA5 PGA3	9.88e-05	17	101	3	IPR021109
Domain	Somatomedin_B_chordata	ENPP2 ENDOU	2.86e-04	5	101	2	IPR020436
Domain	ARM-type_fold	PSMD5 HUWE1 PAIP1 FMNL3 PI4KA ARMH3 GCN1 IPO11	5.07e-04	339	101	8	IPR016024
Domain	Somatomedin_B	ENPP2 ENDOU	7.94e-04	8	101	2	PF01033
Domain	PAM2	PAIP1 ATXN2	1.02e-03	9	101	2	PF07145
Domain	SO	ENPP2 ENDOU	1.02e-03	9	101	2	SM00201
Domain	MYTH4	MYO7A MYO7B	1.02e-03	9	101	2	PS51016
Domain	MyTH4_dom	MYO7A MYO7B	1.02e-03	9	101	2	IPR000857
Domain	MyTH4	MYO7A MYO7B	1.02e-03	9	101	2	PF00784
Domain	Ataxin-2_C	PAIP1 ATXN2	1.02e-03	9	101	2	IPR009818
Domain	MyTH4	MYO7A MYO7B	1.02e-03	9	101	2	SM00139
Domain	Somatomedin_B_dom	ENPP2 ENDOU	1.27e-03	10	101	2	IPR001212
Domain	SMB_1	ENPP2 ENDOU	1.27e-03	10	101	2	PS00524
Domain	SMB_2	ENPP2 ENDOU	1.27e-03	10	101	2	PS50958
Domain	Quinoprot_gluc/sorb_DH	HHIPL2 TBL1X	1.84e-03	12	101	2	IPR011041
Domain	FERM_M	MYO7A MYO7B FERMT3	1.97e-03	46	101	3	PF00373
Domain	ER_TARGET	B3GLCT PDIA4 EDEM3	2.09e-03	47	101	3	PS00014
Domain	-	MYO7A MYO7B FERMT3	2.36e-03	49	101	3	1.20.80.10
Domain	FERM_central	MYO7A MYO7B FERMT3	2.36e-03	49	101	3	IPR019748
Domain	FERM_1	MYO7A MYO7B FERMT3	2.50e-03	50	101	3	PS00660
Domain	FERM_2	MYO7A MYO7B FERMT3	2.50e-03	50	101	3	PS00661
Domain	FERM_3	MYO7A MYO7B FERMT3	2.50e-03	50	101	3	PS50057
Domain	Band_41_domain	MYO7A MYO7B FERMT3	2.50e-03	50	101	3	IPR019749
Domain	B41	MYO7A MYO7B FERMT3	2.50e-03	50	101	3	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	MYO7A MYO7B FERMT3	2.50e-03	50	101	3	IPR014352
Domain	SEA	MUC3B MUC16	2.53e-03	14	101	2	SM00200
Domain	Synaptotagmin	SYT11 SYT4	5.16e-03	20	101	2	IPR001565
Pathway	WP_GASTRIC_ACID_PRODUCTION	PGA4 PGA5 PGA3	2.22e-05	11	74	3	M39726
Pubmed	Close linkage of human chromosomal pepsinogen A genes.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3017318
Pubmed	Serum pepsinogen test for early detection of gastric cancer in a European country.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	21989121
Pubmed	Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	9855083
Pubmed	Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	9797498
Pubmed	The glomerular sieving of pepsinogen A and C in man.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2478370
Pubmed	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3815274
Pubmed	Pepsinogens: physiology, pharmacology pathophysiology and exercise.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	10675278
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB3 CPEB4	2.75e-08	3	106	3	12672660
Pubmed	The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	7926498
Pubmed	Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3780036
Pubmed	Crystal structure of human pepsinogen A.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	9561228
Pubmed	The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	21455714
Pubmed	Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	19800305
Pubmed	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2901984
Pubmed	Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3839486
Pubmed	Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	24170207
Pubmed	Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3467902
Pubmed	The pepsinogens of human gastric mucosa.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	4586732
Pubmed	Relationships between the human pepsinogen DNA and protein polymorphisms.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3014868
Pubmed	Genomic structure and evolution of the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2892778
Pubmed	The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	24383519
Pubmed	Gene structures of pepsinogens A and C.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	1455184
Pubmed	Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2831884
Pubmed	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2799289
Pubmed	CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	19872561
Pubmed	Human pepsinogen A (PGA): an informative gene complex located at 11q13.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	1968039
Pubmed	Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2032552
Pubmed	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	8053437
Pubmed	Analysis of the promoter of a human pepsinogen A gene.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	1812762
Pubmed	O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	7923573
Pubmed	Family and population studies on the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2566575
Pubmed	Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	9061458
Pubmed	Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	12588289
Pubmed	Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2229438
Pubmed	Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	25314140
Pubmed	Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	19890696
Pubmed	Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	23897256
Pubmed	An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	11566730
Pubmed	The effect of acute and chronic protein loading on urinary pepsinogen A excretion.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	1956484
Pubmed	Transcription regulation of human and porcine pepsinogen A.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	8540382
Pubmed	Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	8244094
Pubmed	Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	21407214
Pubmed	Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	22992016
Pubmed	The role of serum pepsinogen in the detection of gastric cancer.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	20981206
Pubmed	Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	6774973
Pubmed	Gastric chief cell-specific transcription of the pepsinogen A gene.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	8504820
Pubmed	Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	21970995
Pubmed	Primary structure of human pepsinogen gene.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	6300126
Pubmed	Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	22304859
Pubmed	Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	24004680
Pubmed	Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	8038355
Pubmed	Serum pepsinogens in gastric cancer screening.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	20428942
Pubmed	Human pepsinogen A isozymogen patterns in serum and gastric mucosa.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	2227273
Pubmed	The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	9525001
Pubmed	Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	7886402
Pubmed	Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	23034090
Pubmed	A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	24125879
Pubmed	Serum pepsinogen and gastric cancer screening.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	17379991
Pubmed	Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	8751234
Pubmed	Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	3554488
Pubmed	Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	21547904
Pubmed	Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.	PGA4 PGA5 PGA3	2.75e-08	3	106	3	23521833
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB2 CPEB3 CPEB4	1.10e-07	4	106	3	30177570
Pubmed	Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.	PGA4 PGA5 PGA3	1.10e-07	4	106	3	23047493
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB2 CPEB3 CPEB4	1.10e-07	4	106	3	12871996
Pubmed	Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.	PGA4 PGA5 PGA3	1.10e-07	4	106	3	11915945
Pubmed	Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.	PGA4 PGA5 PGA3	1.10e-07	4	106	3	8322031
Pubmed	Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.	PGA4 PGA5 PGA3	1.10e-07	4	106	3	17136346
Pubmed	Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.	PGA4 PGA5 PGA3	1.10e-07	4	106	3	12698190
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB2 CPEB3 CPEB4	2.74e-07	5	106	3	20639532
Pubmed	Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.	PGA4 PGA5 PGA3	2.74e-07	5	106	3	22066020
Pubmed	Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.	CPEB2 CPEB3 CPEB4	3.25e-06	10	106	3	27810937
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ICE1 HUWE1 BIRC6 DST ZFHX3 CRYBG3 GCN1 HOMEZ TBL1X	5.64e-06	418	106	9	34709266
Pubmed	Crystal structure of human pepsin and its complex with pepstatin.	PGA4 PGA5	9.20e-06	2	106	2	7663352
Pubmed	Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.	PGA4 PGA5	9.20e-06	2	106	2	2714789
Pubmed	Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.	MYO7B USH1C	9.20e-06	2	106	2	28439001
Pubmed	3D origami electrochemical immunodevice for sensitive point-of-care testing based on dual-signal amplification strategy.	PSG2 MUC16	9.20e-06	2	106	2	25048447
Pubmed	Activation of human pepsinogens.	PGA4 PGA5	9.20e-06	2	106	2	3197840
Pubmed	Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex.	MYO7B USH1C	9.20e-06	2	106	2	26812017
Pubmed	The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.	CPEB2 CPEB3	9.20e-06	2	106	2	32440535
Pubmed	Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.	PGA4 PGA5	9.20e-06	2	106	2	2415509
Pubmed	Hereditary Ataxia Overview	FXN FAT2 ATXN2 ZFHX3 FGF14	9.53e-06	92	106	5	20301317
Pubmed	Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.	ADAP1 FAT2 ATXN2 FGF14	1.21e-05	46	106	4	34815492
Pubmed	Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.	PGA4 PGA5 PGA3	2.17e-05	18	106	3	36057966
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	CPEB2 CPEB3 CPEB4	2.17e-05	18	106	3	30111840
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EXOSC10 MUC16 HUWE1 BIRC6 DNAH7 DST ZBED6 PI4KA SLITRK5 ZFHX3 GCN1	2.61e-05	777	106	11	35844135
Pubmed	Prenatal smoke exposure: effects on infant auditory system and placental gene expression.	USH1C TBL1X	2.76e-05	3	106	2	23665419
Pubmed	Novel mutations of MYO7A and USH1G in Israeli Arab families with Usher syndrome type 1.	MYO7A USH1C	2.76e-05	3	106	2	22219650
Pubmed	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	CPEB3 CPEB4	2.76e-05	3	106	2	17024188
Pubmed	Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells.	MYO7A USH1C	2.76e-05	3	106	2	14578428
Pubmed	Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.	MYO7A USH1C	2.76e-05	3	106	2	20639393
Pubmed	Genetic analysis of Tunisian families with Usher syndrome type 1: toward improving early molecular diagnosis.	MYO7A USH1C	2.76e-05	3	106	2	27440999
Pubmed	A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.	PGA4 PGA5	2.76e-05	3	106	2	2515193
Pubmed	Myosin 7 and its adaptors link cadherins to actin.	MYO7A USH1C	2.76e-05	3	106	2	28660889
Pubmed	ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.	MYO7B USH1C	2.76e-05	3	106	2	26812018
Pubmed	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	CPEB3 CPEB4	2.76e-05	3	106	2	20937770
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	2.76e-05	3	106	2	26398195
Pubmed	Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.	MYO7A USH1C	5.50e-05	4	106	2	16481439
Pubmed	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.	MYO7A USH1C	5.50e-05	4	106	2	30275467
Pubmed	Analysis of subcellular localization of Myo7a, Pcdh15 and Sans in Ush1c knockout mice.	MYO7A USH1C	5.50e-05	4	106	2	21156003
GeneFamily	A-kinase anchoring proteins\|Myosins, class VII\|Deafness associated genes\|FERM domain containing	MYO7A MYO7B	1.31e-05	2	66	2	1102
GeneFamily	CD molecules\|V-set domain containing\|Pregnancy specific glycoproteins	PSG2 PSG11	7.07e-04	11	66	2	1315
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7A MYO7B FERMT3	8.06e-04	50	66	3	1293
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX3 HOMEZ	1.34e-03	15	66	2	529
GeneFamily	Synaptotagmins	SYT11 SYT4	1.72e-03	17	66	2	765
GeneFamily	CD molecules\|Mucins	MUC3B MUC16	2.64e-03	21	66	2	648
ToppCell	ileum\|World / shred on tissue and cell subclass	MYO7B SGK1 USH1C GGT1 DST SLC23A2	3.15e-06	170	105	6	9f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRAS1 MYO7B USH1C DNAH7 GGT1 PKHD1	4.81e-06	183	105	6	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	Nasal_Brush-Immune-Neutrophils\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	DPYD MYO7A SGSH POT1 BST1 PI4KA	5.28e-06	186	105	6	f5aa91dbef29f7efa2b9a728c6539d7541340cd4
Disease	Usher syndrome type 1 (is_implicated_in)	MYO7A USH1C	1.09e-05	2	98	2	DOID:0110826 (is_implicated_in)
Disease	Usher syndrome, type 1B	MYO7A USH1C	1.09e-05	2	98	2	C2931206
Disease	USHER SYNDROME, TYPE I	MYO7A USH1C	1.09e-05	2	98	2	276900
Disease	Usher syndrome (implicated_via_orthology)	MYO7A USH1C	3.27e-05	3	98	2	DOID:0050439 (implicated_via_orthology)
Disease	Usher syndrome (is_implicated_in)	MYO7A USH1C	6.52e-05	4	98	2	DOID:0050439 (is_implicated_in)
Disease	smoking cessation	DPYD ENPP2 BIRC6 AKTIP ATXN2 ZFHX3 FERMT3	1.08e-04	325	98	7	EFO_0004319
Disease	Usher syndrome, type 1A	MYO7A USH1C	1.08e-04	5	98	2	C2931205
Disease	USHER SYNDROME, TYPE IB (disorder)	MYO7A USH1C	1.08e-04	5	98	2	C1848638
Disease	USHER SYNDROME, TYPE IA, FORMERLY	MYO7A USH1C	1.08e-04	5	98	2	C1848639
Disease	USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY	MYO7A USH1C	1.08e-04	5	98	2	C1848640
Disease	Usher syndrome type 1	MYO7A USH1C	1.08e-04	5	98	2	cv:C1568247
Disease	Usher Syndrome, Type I	MYO7A USH1C	1.62e-04	6	98	2	C1568247
Disease	right ventricular systolic volume measurement	FMNL3 ATXN2 SLC23A2	2.15e-04	35	98	3	EFO_0021815
Disease	Hereditary retinal dystrophy	MYO7A USH1C	2.27e-04	7	98	2	C0154860
Disease	Usher syndrome	MYO7A USH1C	2.27e-04	7	98	2	cv:C0271097
Disease	C-X-C motif chemokine 10 measurement	FRAS1 PSG2 PPEF2 ATXN2	4.87e-04	109	98	4	EFO_0008056
Disease	Ciliopathies	MYO7A USH1C PKHD1 IFT80	5.04e-04	110	98	4	C4277690
Disease	smoking status measurement, forced expiratory volume	PSG11 PKHD1	5.89e-04	11	98	2	EFO_0004314, EFO_0006527
Disease	Disorder of eye	TCTN3 FRAS1 B3GLCT MYO7A USH1C	7.22e-04	212	98	5	C0015397
Disease	left ventricular diastolic function measurement	DENND3 FMNL3 ATXN2	7.79e-04	54	98	3	EFO_0008204
Disease	survival time, breast carcinoma	ZFHX3 TBL1X	8.32e-04	13	98	2	EFO_0000305, EFO_0000714
Disease	C-X-C motif chemokine 11 measurement	PPEF2 ATXN2	9.68e-04	14	98	2	EFO_0008057
Disease	chromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)	PI4KAP2 PI4KA	9.68e-04	14	98	2	DOID:0060413 (implicated_via_orthology)
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	DPYD EDEM3 PKHD1 SYT4 ZFHX3 HOMEZ	1.37e-03	364	98	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	melanoma	MYO7A POT1 ZNF831 SYT4 HOXB13	1.45e-03	248	98	5	C0025202
Disease	memory performance	DPYD PDGFRL FXN AKTIP KIAA1549L SYT4	2.46e-03	409	98	6	EFO_0004874
Disease	cleft lip	MUC16 ICE1 USH1C DST MDGA1	2.61e-03	284	98	5	EFO_0003959

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVFDETFTFYGIPYS	SYT11	221	Q9BT88
RKYEEGFDPYSMFTP	USH1C	431	Q9Y6N9
PTGAYPIKGFFADYE	BST1	196	Q10588
YGLYSSPFDPVLFDL	BIRC6	1496	Q9NR09
HYAFSENPTVFKYPD	B3GLCT	171	Q6Y288
PTYFRGYESPTLSKD	CRYBG3	1926	Q68DQ2
VFKFTVYIPDNYPDG	AKTIP	121	Q9H8T0
KCSYPYGFFLEPKST	ANKIB1	661	Q9P2G1
PFYALFSSLGSFYIP	ADRA1B	201	P35368
TYGDTFLPTPSSYDE	ARMH3	536	Q5T2E6
FGPYDNYIPVSELSK	CYLC2	11	Q14093
YGASVSAKPELPLFY	DPYD	511	Q12882
ESKVPSFYYRPTPSD	ADAP1	86	O75689
LFPATDDSLYYKGTP	CAPN5	31	O15484
SPGAIYAASKLSYFD	DENND3	846	A2RUS2
IFGDTPYIPFRDAAY	CDC14C	126	A4D256
TKGYGFVSFKDPSDY	RBM42	421	Q9BTD8
DVFPTKYGREFPSSF	MOB2	126	Q70IA6
SETEPGSFLYYAPFD	PGA5	166	P0DJD9
SAKAYSPEFYFDTPN	MDGA1	631	Q8NFP4
KPYTFEDYDVSFGSG	FXN	116	Q16595
YFTVSPDSDPYKATS	MUC16	6316	Q8WXI7
EFYSSYPGLPEPSKV	MUC16	8951	Q8WXI7
PYVTTDYNFKLPGAS	NOL9	661	Q5SY16
SYFLGPDAPSYFSLD	PCDH20	571	Q8N6Y1
YPDTLLGSSEKEFFY	KCND1	61	Q9NSA2
KDGYVPFFDPTGTIY	FRAS1	3726	Q86XX4
GPGTYFFKSDLETYV	LEXM	211	Q3ZCV2
LPYFESFGTYSTKLP	HACD4	171	Q5VWC8
YVSSLYDAFPKVPEG	DST	246	Q03001
PYNKETSPSFYFAIS	ATXN2	1111	Q99700
YAYKPSKNFEDSSPE	IPO11	331	Q9UI26
FAESTYFLYKATGDP	EDEM3	406	Q9BZQ6
GTYFEVKIPSDTFYD	DAG1	511	Q14118
TLGCYPFYKTDPFIF	POLD2	381	P49005
YPSDRSAPIFSKSEY	FAT2	1651	Q9NYQ8
YYKEVGSAFIGSSPE	ENDOU	341	P21128
SVPPKTFAFPYFEGS	DBX1	131	A6NMT0
GYLYPSELFTPECKF	FGF14	131	Q92915
EKIYSTAFDYFSCPP	PI4KA	1376	P42356
IYSTAFDYFSCPPKF	PI4KAP1	121	Q8N8J0
PFITEALYGPKYTFF	DSE	466	Q9UL01
EKATFASVTYPRGYP	DSE	626	Q9UL01
SYAEYKSFEESFPSP	MEIKIN	136	A0A087WXM9
NYLPITFGDKFTPYV	GCN1	1761	Q92616
GYYDFPAVETSKGLT	KIAA1549L	1416	Q6ZVL6
YFPEKSTKYVFDSAP	ODF3	106	Q96PU9
VGFPKYGAYVPTELF	PLA2G4F	521	Q68DD2
YPPSATTLHFEFYAD	HUWE1	191	Q7Z6Z7
AEDYKFDFPVSYLPG	SMPD4	141	Q9NXE4
SKLSVNAPEFYPSGY	PAIP1	126	Q9H074
SETEPGSFLYYAPFD	PGA3	166	P0DJD8
AYFDYKDESGFPKPP	NDFIP1	51	Q9BT67
PSFKYEDFGPLFTAK	FUCA2	96	Q9BTY2
PEKEFTPYDYSQSDF	EXOSC10	811	Q01780
LYSYEGRFISSPKFP	IFT80	396	Q9P2H3
LPSSFAPETYFGEYT	ICE1	361	Q9Y2F5
AESKSYFPPKGYAFL	CPEB2	366	Q7Z5Q1
ESKSYFPPKGYAFLL	CPEB3	476	Q8NE35
DGKPPYSYASLITFA	FOXJ3	76	Q9UPW0
SIDKSYFFELGTYDP	GALNT5	676	Q7Z7M9
YFGESPKTTPPSVFF	FMNL3	901	Q8IVF7
PFPEKGTIYDYQFVT	DNAH7	1906	Q8WXX0
SDYKFDSSGIYFVPP	DNAH7	3671	Q8WXX0
YYVAPSDFASKPSFL	HOXD11	21	P31277
AESKSYFPPKGYAFL	CPEB4	506	Q17RY0
LKTFSYFPYPSLADI	HOMEZ	71	Q8IX15
SAYAPRGSIYKFVDP	HHIPL2	586	Q6UWX4
AGEEYPSRPTEFAFY	HOXB13	116	Q92826
KYPESISYFSGPAAA	PRDM13	491	Q9H4Q3
GYFTFTLYLETPKPS	PSG11	136	Q9UQ72
PSVYAFYSEQPDFSG	ENPP2	301	Q13822
FYKNGLPSPERSYVF	PPEF2	191	O14830
FYGTAIAVYFSPSSP	OR1C1	251	Q15619
SETEPGSFLYYAPFD	PGA4	166	P0DJD7
PTGYEEFYFPLVEAT	MUC3B	1071	Q9H195
SYFPEYTGPKQDVRA	GNA14	286	O95837
DPAFDETFTFYGIPY	SYT4	216	Q9H2B2
SYAPRAEAEKTFSYP	TRAPPC4	21	Q9Y296
SVYRYPPKSGSYFAS	RNF157	21	Q96PX1
DSAVTPGPYYSKTFL	SPATA22	271	Q8NHS9
AKYPAESPDYFVDFP	FANCL	156	Q9NW38
SIYAKFFPDTDPKAY	RCVRN	51	P35243
FRLSPSDKYPGFGFE	FOXN1	91	O15353
EAFLGFSYAPPTDSF	SGK1	416	O00141
FFKPPYLSKGTDYCS	POT1	31	Q9NUX5
GFRAKYSFIPDPDFT	NETO2	151	Q8NC67
PSDRYKVEGFPTIYF	PDIA4	591	P13667
SSYSTPFFPYGVKFL	PKHD1	2016	P08F94
FFTEKGELFVPSPSY	PDGFRL	166	Q15198
IYSTAFDYFSCPPKF	PI4KAP2	121	A4QPH2
VGPETVYPFDFAYTE	SGSH	126	P51688
FSIPYPSYAIFGSKT	SGSH	326	P51688
PYTEANYKPTFLSDD	ARNTL	131	O00327
EPVYSVAFSPDGKYL	TBL1X	506	O60907
VFAKDAYPGSYVPTV	RND2	26	P52198
FPPDSTKYGFYARTD	SLC23A2	336	Q9UGH3
EYPKFPCSPAAYTFS	SLITRK5	876	O94991
SKYPAANAYTIPSDF	STPG1	106	Q5TH74
FPSNLGYSELAFYTP	VPS18	261	Q9P253
FVTKAYPVSGSPEYL	PHF3	1221	Q92576
FKYYSFFDLDPKTDP	FERMT3	251	Q86UX7
APDIRKFSYFPSYVD	TSTD2	326	Q5T7W7
YSAGRYDPSVKPPFD	PTGR3	81	Q8N4Q0
APDYRLPSETYFFTK	ZBED6	441	P86452
DSDPFSSFYLPGFVK	PSMD5	261	Q16401
GYFTFTLYLETPKPS	PSG2	136	P11465
DLPTPYTYKDSFHFD	ZNF831	441	Q5JPB2
SFYRAGDPILTYFPK	TCTN3	206	Q6NUS6
SPAPSFYSKEYDNEG	ZFHX3	2896	Q15911
DTTHPISYYKPEFYT	GGT1	361	P19440
SRFYEAYKFSGPSLP	MYO7A	1471	Q13402
DGLAEYTFPKFAVTY	MYO7B	966	Q6PIF6