Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

2.81e-055342GO:0140444
GeneOntologyBiologicalProcesscentrosome localization

CCDC141 SYNE1 SYNE2

2.36e-0535333GO:0051642
GeneOntologyBiologicalProcessmicrotubule organizing center localization

CCDC141 SYNE1 SYNE2

2.57e-0536333GO:0061842
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

1.40e-0411342GO:0034992
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

1.40e-0411342GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.40e-0411342GO:0106094
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.40e-0411342GO:0034993
GeneOntologyCellularComponentouter kinetochore

PMF1 ZWINT

6.93e-0424342GO:0000940
HumanPhenoIchthyosis

KRT2 CCDC141 DSP SYNE1 SYNE2

1.94e-0614495HP:0008064
HumanPhenoAbnormal muscle fiber emerin

SYNE1 SYNE2

4.15e-05692HP:0030116
HumanPhenoAbsent muscle fiber emerin

SYNE1 SYNE2

4.15e-05692HP:0030117
HumanPhenoHypertriglyceridemia

MAGEL2 LYST SYNE1 SYNE2

5.36e-0513594HP:0002155
HumanPhenoDecreased cervical spine flexion due to contractures of posterior cervical muscles

SYNE1 SYNE2

5.80e-05792HP:0004631
HumanPhenoAbnormality of the voice

GIGYF2 MAGEL2 GRIN2A CCDC141 SYNE1 SYNE2

9.24e-0554596HP:0001608
HumanPhenoAcantholysis

KRT2 DSP

1.24e-041092HP:0100792
HumanPhenoVentricular escape rhythm

SYNE1 SYNE2

1.51e-041192HP:0005155
HumanPhenoHyperlipidemia

MAGEL2 LYST SYNE1 SYNE2

1.51e-0417694HP:0003077
HumanPhenoProximal upper limb amyotrophy

SYNE1 SYNE2

2.14e-041392HP:0008948
HumanPhenoEpidermal thickening

KRT2 CCDC141 DSP SYNE1 SYNE2

2.18e-0437995HP:0011368
HumanPhenoAbnormality of the musculature of the upper arm

SYNE1 SYNE2

2.50e-041492HP:0001457
HumanPhenoAbnormality of the larynx

GIGYF2 MAGEL2 GRIN2A CCDC141 SYNE1 SYNE2

2.89e-0466696HP:0001600
HumanPhenoLimb-girdle muscular dystrophy

SYNE1 SYNE2

3.72e-041792HP:0006785
HumanPhenoThickened skin

KRT2 CCDC141 DSP SYNE1 SYNE2

4.01e-0443195HP:0001072
HumanPhenoType 1 muscle fiber atrophy

SYNE1 SYNE2

4.18e-041892HP:0011807
HumanPhenoAbnormality of lipoprotein cholesterol concentration

MAGEL2 SYNE1 SYNE2

5.02e-049693HP:0010979
HumanPhenoProximal lower limb amyotrophy

SYNE1 SYNE2

5.19e-042092HP:0008956
HumanPhenoAbnormality of the upper respiratory tract

GIGYF2 MAGEL2 GRIN2A CCDC141 DSP SYNE1 SYNE2

5.47e-04111197HP:0002087
HumanPhenoAbnormality thigh musculature morphology

SYNE1 SYNE2

5.73e-042192HP:0001441
HumanPhenoSudden cardiac death

DSP SYNE1 SYNE2

7.89e-0411293HP:0001645
HumanPhenoIntellectual disability, borderline

MAGEL2 GRIN2A

8.15e-042592HP:0006889
DomainSpectrin_repeat

CCDC141 DSP SYNE1 SYNE2

1.43e-0729314IPR002017
DomainSpectrin

CCDC141 SYNE1 SYNE2

7.17e-0623313PF00435
DomainKASH

SYNE1 SYNE2

1.60e-054312PF10541
DomainKASH

SYNE1 SYNE2

1.60e-054312IPR012315
DomainKASH

SYNE1 SYNE2

1.60e-054312SM01249
DomainKASH

SYNE1 SYNE2

1.60e-054312PS51049
DomainSpectrin/alpha-actinin

DSP SYNE1 SYNE2

1.99e-0532313IPR018159
DomainSPEC

DSP SYNE1 SYNE2

1.99e-0532313SM00150
DomainCH

SYNE1 ARHGEF6 SYNE2

1.69e-0465313SM00033
DomainCH

SYNE1 ARHGEF6 SYNE2

2.10e-0470313PF00307
Domain-

SYNE1 ARHGEF6 SYNE2

2.19e-04713131.10.418.10
DomainCH

SYNE1 ARHGEF6 SYNE2

2.38e-0473313PS50021
DomainCH-domain

SYNE1 ARHGEF6 SYNE2

2.58e-0475313IPR001715
DomainActinin_actin-bd_CS

SYNE1 SYNE2

6.60e-0423312IPR001589
DomainACTININ_2

SYNE1 SYNE2

6.60e-0423312PS00020
DomainACTININ_1

SYNE1 SYNE2

6.60e-0423312PS00019
DomainGDS_CDC24_CS

ARHGEF6 TIAM2

1.90e-0339312IPR001331
DomainDH_1

ARHGEF6 TIAM2

4.89e-0363312PS00741
DomainRhoGEF

ARHGEF6 TIAM2

5.67e-0368312SM00325
DomainDH_2

ARHGEF6 TIAM2

6.00e-0370312PS50010
DomainRhoGEF

ARHGEF6 TIAM2

6.00e-0370312PF00621
DomainDH-domain

ARHGEF6 TIAM2

6.17e-0371312IPR000219
Domain-

ARHGEF6 TIAM2

6.17e-03713121.20.900.10
DomainWD40

TAF5 LYST WDTC1

8.90e-03259313PF00400
DomainSH3_2

TJP1 ARHGEF6

8.94e-0386312IPR011511
DomainSH3_2

TJP1 ARHGEF6

8.94e-0386312PF07653
DomainWD40

TAF5 LYST WDTC1

9.76e-03268313SM00320
DomainWD40_repeat

TAF5 LYST WDTC1

1.02e-02272313IPR001680
DomainWD_REPEATS_1

TAF5 LYST WDTC1

1.08e-02278313PS00678
DomainWD_REPEATS_2

TAF5 LYST WDTC1

1.09e-02279313PS50082
DomainWD_REPEATS_REGION

TAF5 LYST WDTC1

1.09e-02279313PS50294
DomainWD40_repeat_dom

TAF5 LYST WDTC1

1.29e-02297313IPR017986
PathwayREACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS

DSP TJP1

1.24e-0410242MM14956
PathwayREACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS

DSP TJP1

1.51e-0411242M9990
PathwayKEGG_MEDICUS_REFERENCE_ORGANIZATION_OF_THE_OUTER_KINETOCHORE

PMF1 ZWINT

4.67e-0419242M47885
Pubmed

Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium.

DSP TJP1 ARHGEF6

7.54e-071835325139745
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

9.84e-07235222768332
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

9.84e-07235217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

9.84e-07235231578382
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

9.84e-07235211792814
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

9.84e-07235224931616
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

9.84e-07235217267447
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

9.84e-07235224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

9.84e-07235224586179
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

2.95e-06335217462627
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

2.95e-06335210878022
Pubmed

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.

SYNE1 SYNE2

2.95e-06335233472039
Pubmed

A Role for DLK in Microtubule Reorganization to the Cell Periphery and in the Maintenance of Desmosomal and Tight Junction Integrity.

DSP TJP1

2.95e-06335227519653
Pubmed

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

SYNE1 SYNE2

2.95e-06335225516977
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

2.95e-06335216079285
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

2.95e-06335212408964
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

GIGYF2 TLK1 SYNE1 SYNE2 SMG6

3.00e-0622535512168954
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GIGYF2 GRIN2A TAF5 TJP1 PRRC2A SYNE1 SYNE2 SMG6

4.07e-0696335828671696
Pubmed

Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

GIGYF2 TAF5 SBNO1 SMG6

4.43e-0610935423974872
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 SYNE2

5.90e-06435219596800
Pubmed

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

SYNE1 SYNE2

5.90e-06435216648470
Pubmed

LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.

SYNE1 SYNE2

5.90e-06435223071752
Pubmed

Mouse embryonic submandibular gland epithelium loses its tissue integrity during early branching morphogenesis.

DSP TJP1

5.90e-0643528950514
Pubmed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

SYNE1 SYNE2

5.90e-06435228716842
Pubmed

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.

TIAM2 SYNE2

5.90e-06435229844364
Pubmed

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.

SYNE1 SYNE2

5.90e-06435220108321
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KRT2 TLK1 ZNF789 SBNO1 DSP TJP1 LYST SYNE1 SYNE2

9.39e-06144235935575683
Pubmed

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

SYNE1 SYNE2

9.82e-06535218396275
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

SYNE1 SYNE2

9.82e-06535222632968
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

GIGYF2 GRIN2A TAF5 SBNO1 SMG6

1.27e-0530335525056061
Pubmed

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.

SYNE1 SYNE2

1.47e-05635233058875
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 SYNE2

1.47e-05635218827015
Pubmed

Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells.

DSP TJP1

2.06e-05735218292208
Pubmed

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.

PMF1 ZWINT

2.06e-05735227881301
Pubmed

Tagging genes with cassette-exchange sites.

GIGYF2 TLK1 TAF5 SBNO1 SMG6

2.06e-0533535515741177
Pubmed

Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.

DSP TJP1

2.74e-05835220093627
Pubmed

Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization.

PMF1 ZWINT

4.40e-051035224530301
Pubmed

Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.

SYNE1 SYNE2

4.40e-051035228533284
Pubmed

Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves.

DSP TJP1

4.40e-051035216543498
Pubmed

Nuclear membrane proteins with potential disease links found by subtractive proteomics.

SYNE1 SYNE2

4.40e-051035212958361
Pubmed

A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

PMF1 ZWINT

4.40e-051035221633384
Pubmed

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.

PMF1 ZWINT

4.40e-051035215371340
Pubmed

Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.

PMF1 ZWINT

4.40e-051035221199919
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

KRT2 DSP TRIM64C PRRC2A

5.02e-0520235433005030
Pubmed

The KMN protein network--chief conductors of the kinetochore orchestra.

PMF1 ZWINT

5.38e-051135223418356
Pubmed

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.

SYNE1 SYNE2

5.38e-051135222826121
Pubmed

Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.

DSP TJP1

5.38e-051135221038445
Pubmed

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.

PMF1 ZWINT

6.45e-051235215502821
Pubmed

KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.

SYNE1 SYNE2

7.62e-051335221177258
Pubmed

Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.

KRT2 DSP

7.62e-05133528999895
Pubmed

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

SYNE1 SYNE2

8.89e-051435219874786
Pubmed

MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis.

DSP TJP1

8.89e-051435214627958
Pubmed

Periderm prevents pathological epithelial adhesions during embryogenesis.

DSP TJP1

1.02e-041535225133425
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RMI1 TLK1 TJP1 PMF1 SYNE1 ZWINT WDTC1

1.30e-04115535720360068
Pubmed

Desmoplakin is essential in epidermal sheet formation.

DSP TJP1

1.33e-041735211781569
Pubmed

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

TLK1 PRRC2A

1.66e-041935222267201
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

GIGYF2 TAF5 DSP TJP1 PRRC2A

2.11e-0454935538280479
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

CCDC141 SYNE1

2.24e-042235212812986
Pubmed

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.

DSP TJP1

2.46e-042335218809908
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

GRIN2A TJP1

2.46e-042335216637659
Pubmed

Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.

DSP TJP1

2.46e-042335219841136
Pubmed

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.

DSP TJP1

2.91e-042535223132931
Pubmed

Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.

DSP TJP1

2.91e-042535231410202
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

KRT2 GIGYF2 SBNO1 DSP TJP1 PRRC2A SYNE2

4.49e-04141535728515276
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GIGYF2 DSP TJP1 PRRC2A SYNE2

4.68e-0465335522586326
Pubmed

Lem2 is essential for cardiac development by maintaining nuclear integrity.

SYNE1 SYNE2

4.79e-043235237067297
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

GIGYF2 NOL7 DSP TJP1 SYNE1 SYNE2

5.02e-04102435624711643
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

KRT2 GIGYF2 PRRC2A SYNE2

5.35e-0437535432788342
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

KRT2 DSP TJP1 LNPEP PRRC2A SYNE2

5.70e-04104935627880917
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

ARHGEF6 TIAM2

6.76e-043835211756498
Pubmed

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.

DSP TJP1 PRRC2A

7.04e-0417335323979707
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

RMI1 NOL7 ARHGEF6 TIAM2 SYNE2 ZWINT

8.17e-04112435621900206
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

GIGYF2 DSP TJP1

8.42e-0418435332908313
Pubmed

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

ARHGEF6 TIAM2

8.66e-044335212376548
Pubmed

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.

GIGYF2 MAGEL2

9.90e-044635234265304
Pubmed

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

TAF5 TJP1

9.90e-044635225209997
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

RMI1 TLK1 SBNO1 TJP1

1.00e-0344435434795231
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

GIGYF2 TLK1 DSP PRRC2A ARHGEF6

1.01e-0377435515302935
CytobandEnsembl 112 genes in cytogenetic band chr11p11

FOLH1 TRIM64C

6.11e-03153352chr11p11
CytobandEnsembl 112 genes in cytogenetic band chr6q25

SYNE1 TIAM2

6.98e-03164352chr6q25
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

7.70e-0642121252
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF6 TIAM2

2.64e-0366212722
GeneFamilyWD repeat domain containing

TAF5 LYST WDTC1

3.30e-03262213362
GeneFamilyPDZ domain containing

TJP1 TIAM2

1.33e-021522121220
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF6 TIAM2

2.35e-02206212682
CoexpressionGSE21670_UNTREATED_VS_TGFB_IL6_TREATED_CD4_TCELL_UP

TAF5 CCDC141 SYNE2 ZWINT

1.27e-04194354M7467
CoexpressionGSE3982_MAC_VS_NKCELL_DN

SYNE1 RUSF1 TIAM2 SYNE2

1.38e-04198354M5509
CoexpressionGSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_UP

TAF5 TJP1 SYNE1 SYNE2

1.40e-04199354M9410
CoexpressionGSE4142_PLASMA_CELL_VS_MEMORY_BCELL_DN

KRT2 CCDC141 PMF1 TIAM2

1.43e-04200354M6396
CoexpressionGSE32986_UNSTIM_VS_CURDLAN_HIGHDOSE_STIM_DC_DN

TIGIT SLC35D2 SYNE1 SYNE2

1.43e-04200354M8618
CoexpressionGSE411_UNSTIM_VS_400MIN_IL6_STIM_MACROPHAGE_DN

NOL7 PMF1 PRRC2A ZWINT

1.43e-04200354M5996
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_16H_BMDC_UP

KRT2 SBNO1 SYNE1 RUSF1

1.43e-04200354M3976
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

NOL7 TLK1 SBNO1 TJP1 SYNE2

4.58e-0719835576d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellsevere-Treg|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TLK1 TIGIT CCDC141 SLC35D2 SYNE2

4.58e-071983554935b40fc848037a06055f30d90bde940b9d5321
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

TIGIT CCDC141 LYST ARHGEF6 SYNE2

4.69e-07199355f307d4887b28cf60a591439e278fd668409cb104
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-dn_T|COVID-19_Severe / Disease, condition lineage and cell class

TIGIT CCDC141 LYST ARHGEF6 SYNE2

4.81e-07200355d01aa5fccada22f97d8350ad5888df2aadb5bb1c
ToppCellCOVID-19_Severe-multiplets|COVID-19_Severe / disease group, cell group and cell class

PKDREJ SYNE1 NCCRP1 SYNE2

6.04e-06152354451745151322c2fcea22dbb3dba681e12634a510
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TLK1 TIGIT CCDC141 SYNE2

1.18e-051803546bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCellControl-Lymphoid-Tregs|Control / Condition, Lineage and Cell class

TIGIT CCDC141 SYNE1 SYNE2

1.34e-051863546144f32a370594e45b91da142b4f435370c69b9a
ToppCellMS-Treg-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

TLK1 TIGIT CCDC141 SYNE2

1.43e-05189354b1310eed6113b3536868340a5b2b2587ad377fa9
ToppCellMS-Treg|MS / Condition, Cell_class and T cell subcluster

TLK1 TIGIT CCDC141 SYNE2

1.43e-051893543fa79242fb3dba4a3f52276da0124ba260423fb6
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TLK1 TIGIT CCDC141 SYNE2

1.52e-051923541fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCellIIH-CD8-CD8_1|IIH / Condition, Cell_class and T cell subcluster

TIGIT LYST SYNE1 SYNE2

1.55e-05193354c5a4926003906d6726155f19061b73fb45d9962c
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

TIGIT LYST SYNE1 SYNE2

1.55e-05193354995781d87a919c0380750878bafe584342bb83ad
ToppCellCOVID-19-Lymphoid-Tregs|COVID-19 / Condition, Lineage and Cell class

TLK1 TIGIT CCDC141 SYNE2

1.61e-05195354284cfff4d59ecc1430997b118de17fee167dcbb1
ToppCellCOVID-19-Lymphoid-Tregs|Lymphoid / Condition, Lineage and Cell class

TLK1 TIGIT CCDC141 SYNE2

1.61e-051953549ad844d9d5aac39d133ae8ab9c4839300f08064c
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

GRIN2A TJP1 SYNE1 SYNE2

1.65e-051963544ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT LNPEP SYNE1 SYNE2

1.68e-0519735448311c7d85ffabf59fd1685c31c18b3e84a145b5
ToppCellSevere_COVID-19-T/NK-NK|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

TIGIT LNPEP SYNE1 SYNE2

1.68e-05197354cc20162892b59e48653981f91fc9a0c27064444d
ToppCellmild-Treg|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TLK1 TIGIT CCDC141 SYNE2

1.68e-0519735439800e6e83f2d333b753d121c7aeb2912b91faa2
ToppCellT_cells-Treg_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

TLK1 TIGIT CCDC141 SYNE2

1.68e-05197354de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCellSevere-Lymphoid-NK-NK|Severe / Condition, Lineage, Cell class and cell subclass

TIGIT LNPEP SYNE1 SYNE2

1.68e-05197354d5b94f9f73e9d050245841b19b046242a32c6258
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT LNPEP SYNE1 SYNE2

1.68e-05197354a26dd66a6bd08b46657b3a7c41669e206a8887b3
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT LNPEP SYNE1 SYNE2

1.68e-0519735492f35ea602489efd29ce3a8a186d1f70d65faf40
ToppCellmild-dn_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TIGIT CCDC141 ARHGEF6 SYNE2

1.68e-0519735407a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCellCOVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

TIGIT LNPEP SYNE1 SYNE2

1.68e-05197354d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TIGIT DSP NCCRP1 SYNE2

1.68e-05197354d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCellSevere-Lymphoid-NK|Severe / Condition, Lineage, Cell class and cell subclass

TIGIT LNPEP SYNE1 SYNE2

1.71e-0519835426b6d20527d22ce68067cdaea6b4330cb779f91b
ToppCellVE-CD8-CD8_1|VE / Condition, Cell_class and T cell subcluster

TIGIT LYST SYNE1 SYNE2

1.71e-051983549747a486fddec917a3753651de0b2079ac2385ee
ToppCellsevere-Treg|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TIGIT CCDC141 SLC35D2 SYNE2

1.71e-05198354377980b9f7d02818e1d145e6884604f8bfacc4f2
ToppCellmild-Treg|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TLK1 TIGIT CCDC141 SYNE2

1.71e-051983540269617c0628003d2a13dab98abfd2d15775d16a
ToppCellVE-CD8|VE / Condition, Cell_class and T cell subcluster

TIGIT LYST SYNE1 SYNE2

1.75e-051993549ae4d3e93b6e0861258e567c901ec34f04ded547
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TIGIT LNPEP SYNE1 SYNE2

1.75e-05199354df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TIGIT LNPEP SYNE1 SYNE2

1.75e-05199354ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCellSevere-Lymphoid|Severe / Condition, Lineage, Cell class and cell subclass

TIGIT SYNE1 SYNE2 ZWINT

1.75e-05199354928e346b0f31d991ebab12fefb4eb9f4249e601d
ToppCellSevere-Lymphoid-T|Severe / Condition, Lineage, Cell class and cell subclass

TIGIT SYNE1 SYNE2 ZWINT

1.75e-05199354ad2be3739721b7bfc2bd50eafd01d4325b01016e
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-Treg|Leuk-UTI / Disease, condition lineage and cell class

TLK1 TIGIT CCDC141 SYNE2

1.75e-05199354100f45e04f284551b29ef0406476bdc347ddbf7e
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KRT2 TIGIT SYNE1 SYNE2

1.78e-05200354eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

TIGIT LNPEP SYNE1 SYNE2

1.78e-052003542281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellControl-Control-Lymphocyte-T/NK-dn_T|Control / Disease, condition lineage and cell class

TIGIT CCDC141 LYST SYNE2

1.78e-0520035410882c59b7aaf8bd4b5c00aa4ddbb9f7ac5b2cf5
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT CCDC141 SYNE2

1.44e-04130353d47d4ff1263815896470d854d25306eb36919e70
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TIGIT CCDC141 SYNE2

1.44e-04130353ad57b210c96caedadc1027b4d7a56b1bc389b137
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_E|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MAGEL2 PKDREJ ARHGEF6

1.61e-0413535335928195cf34f055b353562c96f451aef2344d64
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TIGIT CCDC141 SYNE2

1.99e-04145353734d85ca7a2e5e040f433cadc5f9be1f25cf2e91
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT CCDC141 SYNE2

1.99e-041453538ba09eb0fd27f25aa90a3ad75d67a9f79f3f4f43
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

TIGIT CCDC141 SYNE2

1.99e-04145353ee99b58462f955b96d036aa67e343db047d66f64
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|367C / Donor, Lineage, Cell class and subclass (all cells)

TIGIT CCDC141 SYNE2

1.99e-0414535329422c908d58081e6a748e362a7ac41bf001444c
ToppCellE16.5-samps-Mesenchymal-Pericyte-pericyte_A|E16.5-samps / Age Group, Lineage, Cell class and subclass

MAGEL2 PKDREJ ARHGEF6

2.11e-04148353c87fe2373418ec0cfe37279003d1c4df4c0d0aac
ToppCellE16.5-samps-Mesenchymal-Pericyte|E16.5-samps / Age Group, Lineage, Cell class and subclass

MAGEL2 PKDREJ ARHGEF6

2.11e-04148353e697a7fb037873c9b11703d1bf836a69fc276e23
ToppCellPND01-03-samps-Mesenchymal-Pericyte|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MAGEL2 PKDREJ ARHGEF6

2.29e-04152353fc9472bc19f997103da535b035105f01429cb08e
ToppCellCOVID-Treg-CD4_Treg|COVID / Condition, Cell_class and T cell subcluster

TIGIT CCDC141 SYNE2

2.33e-0415335347c649fd4231e507f2d4654ccac61faf21a04eff
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT CCDC141 SYNE2

2.33e-041533537480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCellIIH-Treg|IIH / Condition, Cell_class and T cell subcluster

TLK1 TIGIT CCDC141

2.33e-0415335317704e18833812fcf2a2727b1e3f8a9984ba5b59
ToppCellIIH-Treg-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

TLK1 TIGIT CCDC141

2.38e-04154353d2211a892654b92decb208969040920f7ae8ba1e
ToppCellCOVID-19_Severe-Lymphoid_T/NK-dn_T|COVID-19_Severe / Disease group, lineage and cell class

TIGIT ARHGEF6 SYNE2

2.47e-0415635383f25683e0f55472b56f915ee176fc05efc33a31
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|Lung / Manually curated celltypes from each tissue

TIGIT CCDC141 PKDREJ

2.47e-041563530ea6ca3f38109151a2a4fdf63a4f009929cdcc40
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TIGIT CCDC141 SYNE2

2.47e-0415635353ded973358e3e48054130131e959f0d1f4ef60f
ToppCellCOVID-Treg|COVID / Condition, Cell_class and T cell subcluster

TIGIT CCDC141 SYNE2

2.47e-04156353a1dd61d4c9ed8f283f0fcbf875c5fd7807ca370d
ToppCell10x5'-Lung-Myeloid_Monocytic-Cycling_mono|Lung / Manually curated celltypes from each tissue

RMI1 ZWINT SMG6

2.47e-0415635363b8cf14361b282872bc1c5b65d9fbc83e81a089
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|367C / Donor, Lineage, Cell class and subclass (all cells)

TIGIT CCDC141 SYNE2

2.51e-04157353f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCellLeuk-UTI-Lymphocyte-T_NK-gdT|Leuk-UTI / Disease, Lineage and Cell Type

TIGIT SYNE1 SYNE2

2.56e-04158353c4b0af25608cee3d0d2b0193f5ff45d9dc87078b
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGEL2 GRIN2A PKDREJ

2.56e-04158353f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGEL2 GRIN2A PKDREJ

2.56e-041583538c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellInt-URO-Lymphocyte-T_NK-Treg|Int-URO / Disease, Lineage and Cell Type

TLK1 TIGIT SYNE2

2.56e-04158353457d64dceedb67bfff1303334cda1253a839b3d6
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT CCDC141 SYNE2

2.61e-041593536599707107083af6da092fe8984afc8fd89d2bb8
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TIGIT CCDC141 SYNE2

2.61e-04159353916d070d099726f22deb71966efccff00f8ea071
ToppCellControl-Treg|World / Disease group and Cell class

TLK1 TIGIT CCDC141

2.71e-04161353ead9f5a491321f9e307f7c97e47a4ca124f59bb6
ToppCellCOVID-19_Severe-Treg|World / disease group, cell group and cell class

TIGIT CCDC141 SYNE2

2.71e-04161353c6eade2c60c572d823e6e81b5e8d47078671e9b0
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

TIGIT CCDC141 PKDREJ

2.71e-04161353a1f10e04836848b1deaf295fae033f54d1572fcd
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TIGIT SYNE1 SYNE2

2.76e-0416235319395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-Treg|Multiple_Sclerosis / Disease, Lineage and Cell Type

TIGIT CCDC141 SYNE2

2.76e-04162353975d52e3cc101e7592425128e1099d30847a8a42
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TIGIT CCDC141 SYNE2

2.91e-041653539ccce713d4122054bf4bef4a7126d90cf9141b84
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

TAF5 ZNF789 ZWINT

2.91e-041653538728f927502e56f2768b4224e9111939d3d7815a
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT CCDC141 SYNE2

2.91e-04165353dbe231d00843cae917efd1abea6079ace3b45cdf
ToppCellCOVID-19_Moderate-Treg|COVID-19_Moderate / disease group, cell group and cell class

TIGIT CCDC141 SYNE2

3.01e-041673534ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PMF1 SYNE1 SYNE2

3.01e-04167353ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TIGIT SYNE1 SYNE2

3.01e-04167353abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCellmild_COVID-19-Treg|World / disease group, cell group and cell class (v2)

TIGIT CCDC141 SYNE2

3.01e-0416735369330689b6e353c8ee9ea1b63a5eac6ab38d456f
ToppCellCOVID-19_Moderate-Treg|World / disease group, cell group and cell class

TIGIT CCDC141 SYNE2

3.12e-0416935327ad11239559b025bef582f89b2a83501d9d3993
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TIGIT SYNE1 SYNE2

3.12e-04169353f06118754fa62c580b4bcbecff6f9e5fdc2106a0
ToppCellSevere-Lymphoid-T-|Severe / Condition, Lineage, Cell class and cell subclass

TIGIT SYNE1 SYNE2

3.17e-041703535788e1158fde036937d41708e9db3222ca351eb1
ToppCellCOVID-19_Severe-Treg|COVID-19_Severe / disease group, cell group and cell class

TIGIT CCDC141 SYNE2

3.17e-04170353d61269a51283125835884c4aa50623756c4fdda2
ToppCellnormal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T|normal_Pleural_Fluid / Location, Cell class and cell subclass

TIGIT SYNE1 SYNE2

3.23e-041713536be81c20f4e962b414afcedfe478dd59c510d1e1
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TIGIT SYNE1 SYNE2

3.23e-04171353adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCellmild_COVID-19-Treg|mild_COVID-19 / disease group, cell group and cell class (v2)

TIGIT CCDC141 SYNE2

3.28e-0417235377af6324c06b67867e7ce07706536fe38de5ed7b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TIGIT SYNE1 SYNE2

3.28e-0417235386f52f486d67217fc1b8443ab362c975df2974a4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TIGIT SYNE1 SYNE2

3.28e-04172353fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TIGIT SYNE1 SYNE2

3.28e-04172353e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC35D2 DSP SYNE2

3.40e-041743539d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC35D2 DSP SYNE2

3.40e-0417435353cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAF5 ARHGEF6 NCCRP1

3.40e-04174353ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCellHealthy_donor-Treg|World / disease group, cell group and cell class (v2)

TIGIT CCDC141 SYNE2

3.40e-04174353dc3b06420b0ad9c7060571e7bf5714e028d598bf
ToppCellHealthy_donor-Treg|Healthy_donor / disease group, cell group and cell class (v2)

TIGIT CCDC141 SYNE2

3.40e-041743531d76921c8404b5be5fbe9f3157d53578033f2ad2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TIGIT SYNE2 ZWINT

3.45e-0417535316c835e62a3321f6cf6163954889946bbb869498
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TIGIT LYST PMF1

3.51e-0417635356c055488e34605d32562571a2fee621b47c9441
ToppCellHealthy_Control-Lymphoid-T-Treg|Healthy_Control / Condition, Lineage, Cell class and cell subclass

TIGIT CCDC141 SYNE2

3.51e-041763537765a5b04ac117d525201f8eb08e1754e55942ff
ToppCell(1)_T_regulatory|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TIGIT CCDC141 SYNE2

3.57e-041773535cda56b10df1ee8971ce8470d52062e01b703a4e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYST SYNE1 SYNE2

3.63e-0417835301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Treg|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TLK1 TIGIT CCDC141

3.63e-04178353e37142a84d9713ff1571ce9f976842bf5c17c86f
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TIGIT CCDC141 SYNE2

3.69e-04179353593fc323b28304a57ae162f64b0890b893fff446
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIGIT CCDC141 SYNE2

3.69e-04179353708fc0b8ffcb5fac43c52541acb6671fe1cfbb0d
ToppCellCOPD-Lymphoid-T_Regulatory|World / Disease state, Lineage and Cell class

TIGIT CCDC141 SYNE2

3.75e-0418035351a12fbad5fa7bb12e6d616a02ff9b5141e2b063
Drugplakin

DSP TJP1 SYNE1 SYNE2

5.91e-0682334CID000018752
DrugAC1L9LMC

LYST PMF1 SYNE1 SYNE2

6.20e-0683334CID000448113
DrugPrazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; HL60; HT_HG-U133A

KRT2 GRIN2A PKDREJ PRRC2A WDTC1

8.98e-061973353098_UP
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

7.72e-064342cv:CN293514
Diseasevital capacity

RMI1 GRIN2A SLC35D2 DSP SYNE1 ANGPT4 ARHGEF6 TIAM2 SMG6

7.84e-061236349EFO_0004312
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.29e-055342C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.29e-055342C0410190
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.93e-056342cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

1.93e-056342C0410189
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

2.70e-057342C0751337
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

8.44e-0512342DOID:11726 (implicated_via_orthology)
Diseaseovulation

CCDC200 PRRC2A

2.18e-0419342GO_0030728
Diseasebipolar disorder (is_implicated_in)

GRIN2A SYNE1

5.13e-0429342DOID:3312 (is_implicated_in)
Diseasesmoking status measurement, Cannabis use, schizophrenia

RMI1 SMG6

5.13e-0429342EFO_0006527, EFO_0007585, MONDO_0005090
Diseasesphingolipid measurement

PRRC2A SYNE2

9.78e-0440342EFO_0004622
DiseaseMalignant neoplasm of breast

SBNO1 PKDREJ PRRC2A SYNE1 RUSF1 SYNE2

1.29e-031074346C0006142
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GIGYF2 GRIN2A

1.46e-0349342DOID:0060037 (implicated_via_orthology)
Diseasevenous thromboembolism

GRIN2A SBNO1 FOLH1 SMG6

1.87e-03460344EFO_0004286

Protein segments in the cluster

PeptideGeneStartEntry
NQNVDQILWKNAFYQ

SMG6

636

Q86US8
WNSQAQIDQKLANQI

ERVK13-1

336

Q9NX77
NNNQDFQEWLEQLNR

ARHGEF6

531

Q15052
WIQNVSLKFQQHQQT

KIAA0100

51

Q14667
FQEVQQTQALAWQAQ

MAGEL2

606

Q9UJ55
QQNQVLQTKWELLQQ

KRT2

201

P35908
TEQNFQLAKQIQSQW

FOLH1

86

Q04609
LQQNQSWTVKQQCVD

NCCRP1

146

Q6ZVX7
IYKNWRRQQQQQQQQ

FAM157C

66

P0CG43
LQLQVQAQQQAWQAL

PMF1

176

Q6P1K2
FKLLQNQIQQQTWTD

LNPEP

796

Q9UIQ6
VQFLNNAWGIQKKQN

NOL7

226

Q9UMY1
WLMAQQQQELQQKEQ

CCDC200

21

A0A1B0GVQ3
SQVLQICQWDQQENQ

CCDC141

246

Q6ZP82
QQQQQQQQQKLSGWG

GIGYF2

976

Q6Y7W6
EKQQIQNDLNQWKTQ

DSP

1856

P15924
QVKQLEQALQNNTQW

ANGPT4

86

Q9Y264
VNKAAWQKTVNNNQQ

LYST

2856

Q99698
WQKTVNNNQQSLFQR

LYST

2861

Q99698
DQSQQLAVQQKQLWQ

SBNO1

1366

A3KN83
LCWDQSQNQVQVVLN

RUSF1

356

Q96GQ5
LQEKQNNQIWNIVQE

TAF5

321

Q15542
LQQATEFNQWKNVVF

SLC35D2

226

Q76EJ3
KQNLQKWQQFNSDLN

SYNE1

8436

Q8NF91
NQQCQNTVVLWENTK

SYNE2

1506

Q8WXH0
INWIQEENNNVNLSQ

RMI1

31

Q9H9A7
VWQANQALQEYQQKD

PKDREJ

781

Q9NTG1
QQEQLLKQQQQHQWQ

PRRC2A

651

P48634
AFQNLVKQQEWVNQQ

TLK1

321

Q9UKI8
KQQANEAFACQQWTQ

WDTC1

366

Q8N5D0
AVQNQWQLQQEKHLQ

ZWINT

151

O95229
KAIENQIQQWEQNLE

TIAM2

671

Q8IVF5
QVNWEQQDQLLAICN

TIGIT

56

Q495A1
LKEAIQQQQNQLVWV

TJP1

786

Q07157
YLWKINQETQNNLNQ

TRIM64C

146

A6NLI5
QNLNLIQDQNAQTRW

ZNF789

156

Q5FWF6
VYQQDWAQNNALQLQ

GRIN2A

1266

Q12879