Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol-1,3,4-trisphosphate 4-phosphatase activity

INPP4A INPP4B

2.53e-0521012GO:0017161
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

INPP4A INPP4B

2.53e-0521012GO:0016316
GeneOntologyMolecularFunctioninositol-3,4-bisphosphate 4-phosphatase activity

INPP4A INPP4B

2.53e-0521012GO:0052828
GeneOntologyMolecularFunctionaminoacyltransferase activity

MED10 RNF168 TRIM51 UBE2Q1 GGT7 PRKN TRIM50 HERC2 ARIH1 ZNF598 TRIM51G

7.91e-0553210111GO:0016755
GeneOntologyMolecularFunctionubiquitin protein ligase activity

MED10 RNF168 TRIM51 PRKN TRIM50 HERC2 ARIH1 ZNF598 TRIM51G

1.13e-043721019GO:0061630
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

MED10 RNF168 TRIM51 UBE2Q1 PRKN TRIM50 HERC2 ARIH1 ZNF598 TRIM51G

1.42e-0447310110GO:0004842
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate phosphatase activity

INPP4A INPP4B

1.51e-0441012GO:0106017
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

MED10 RNF168 TRIM51 PRKN TRIM50 HERC2 ARIH1 ZNF598 TRIM51G

1.88e-043981019GO:0061659
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

MED10 RNF168 TRIM51 UBE2Q1 PRKN TRIM50 HERC2 ARIH1 ZNF598 TRIM51G

2.68e-0451210110GO:0019787
GeneOntologyMolecularFunctionacyltransferase activity

MED10 RNF168 TRIM51 UBE2Q1 NAT8 GGT7 PRKN TRIM50 HERC2 ARIH1 ZNF598 TRIM51G

5.40e-0477510112GO:0016746
GeneOntologyMolecularFunctioninositol bisphosphate phosphatase activity

INPP4A INPP4B

6.95e-0481012GO:0016312
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 4-phosphatase activity

INPP4A INPP4B

1.11e-03101012GO:0034596
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

NSUN4 TUT4 RNASEL SLFN13 DHX35 TRMT61B PIWIL3 AQR

1.26e-034171018GO:0140098
GeneOntologyCellularComponentciliary basal body

ERC1 BBS9 CEP250 CEP131 CCDC65 ODAD3 PCNT

5.14e-051951037GO:0036064
GeneOntologyCellularComponentcentriole

CCDC57 CEP250 CEP131 HERC2 ODAD3 PCNT

2.10e-041721036GO:0005814
DomainV-SNARE

GOSR1 VTI1B

1.59e-044972PF05008
DomainVesicle_trsprt_v-SNARE_N

GOSR1 VTI1B

1.59e-044972IPR007705
DomainSpectrin

TRIO KALRN MACF1

2.23e-0423973PF00435
DomainSpectrin_repeat

TRIO KALRN MACF1

4.50e-0429973IPR002017
DomainGlycos_transf_1

ALG1L2 PIGA

5.51e-047972PF00534
DomainGlyco_trans_1

ALG1L2 PIGA

5.51e-047972IPR001296
DomainSpectrin/alpha-actinin

TRIO KALRN MACF1

6.04e-0432973IPR018159
DomainSPEC

TRIO KALRN MACF1

6.04e-0432973SM00150
DomainSH3

DOCK2 TRIO KALRN ARHGEF16 SKAP1 MACF1

9.20e-04216976PS50002
DomainSH3_domain

DOCK2 TRIO KALRN ARHGEF16 SKAP1 MACF1

1.01e-03220976IPR001452
DomainE3_UB_ligase_RBR

PRKN ARIH1

1.17e-0310972IPR031127
DomainSPRY

TRIM51 RYR2 FSD1L TRIM50

1.46e-0394974PF00622
DomainSPRY_dom

TRIM51 RYR2 FSD1L TRIM50

1.46e-0394974IPR003877
DomainB30.2/SPRY

TRIM51 RYR2 FSD1L TRIM50

1.52e-0395974IPR001870
DomainB302_SPRY

TRIM51 RYR2 FSD1L TRIM50

1.52e-0395974PS50188
DomainKinase-like_dom

TRIO KALRN MAP3K14 CHD9 RNASEL DCLK3 MACF1 ULK1 STK38L

2.03e-03542979IPR011009
DomainZINC_FINGER_C2H2_1

ZNF536 TUT4 ZNF48 ZBTB48 ZNF407 ZNF224 ZNF225 ZNF462 PRDM10 ZNF256 ZNF598

2.31e-037779711PS00028
DomainIBR

PRKN ARIH1

2.33e-0314972SM00647
DomainIBR

PRKN ARIH1

2.33e-0314972PF01485
DomainS_TKc

TRIO KALRN MAP3K14 RNASEL DCLK3 ULK1 STK38L

2.67e-03359977SM00220
DomainIBR_dom

PRKN ARIH1

2.68e-0315972IPR002867
DomainPkinase

TRIO KALRN MAP3K14 RNASEL DCLK3 ULK1 STK38L

3.71e-03381977PF00069
DomainZF_RING_1

RNF168 TRIM51 PRKN TRIM50 ARIH1 ZNF598

4.11e-03291976PS00518
DomainDH_1

TRIO KALRN ARHGEF16

4.30e-0363973PS00741
DomainZF_RING_2

RNF168 TRIM51 PRKN TRIM50 ARIH1 ZNF598

4.61e-03298976PS50089
DomainCRAL_TRIO

TRIO KALRN

5.26e-0321972PF00650
DomainRhoGEF

TRIO KALRN ARHGEF16

5.33e-0368973SM00325
DomainSH3

DOCK2 TRIO KALRN ARHGEF16 SKAP1

5.38e-03216975SM00326
DomainConA-like_dom

TRIM51 NBEA RYR2 FSD1L TRIM50

5.70e-03219975IPR013320
DomainButyrophylin

TRIM51 FSD1L TRIM50

5.78e-0370973IPR003879
DomainRhoGEF

TRIO KALRN ARHGEF16

5.78e-0370973PF00621
DomainDH_2

TRIO KALRN ARHGEF16

5.78e-0370973PS50010
Domainzf-C2H2_6

ZNF48 ZBTB48 ZNF224 ZNF225 PRDM10 ZNF256

5.92e-03314976PF13912
DomainDH-domain

TRIO KALRN ARHGEF16

6.01e-0371973IPR000219
Domain-

TRIO KALRN ARHGEF16

6.01e-03719731.20.900.10
Domain-

TRIO KALRN

6.29e-03239723.40.525.10
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

TUT4 TRIO KALRN ERC1 ACOT9 NBEA RYR2 GGT7 GMPS POMGNT2 GNB5 SLC4A10 MACF1 CEP131 CRYBG3 SEPTIN10

2.44e-0711391031636417873
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

USP53 TUT4 KIF1A TRIO INPP4A CHD9 SLITRK3 ARHGEF16 CCDC57 GMPS ZNF462 ANKRD11 MACF1 PRKN KDM2A ARIH1 STK38L PCNT

3.64e-0714891031828611215
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

USP53 TRIO ERC1 MAP3K14 ANKRD26 ARHGEF16 TTLL12 ANKRD11 MACF1 CEP131 CRYBG3 ZNF598 AQR

1.65e-068611031336931259
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

KIF1A ERC1 CHGB BBS9 SLC4A10 MACF1

2.36e-06128103630995482
Pubmed

The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.

INPP4A INPP4B

8.69e-06210327608176
Pubmed

The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.

INPP4A INPP4B

8.69e-06210329295334
Pubmed

Audiologic Measures in an Indigenous Community with A2ML1- and FUT2-Related Otitis Media.

A2ML1 FUT2

8.69e-062103236719978
Pubmed

Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.

TRIO KALRN

8.69e-062103226858404
Pubmed

Proximity interactions among centrosome components identify regulators of centriole duplication.

CCDC57 CEP250 A2ML1 CEP131 PCNT

1.31e-05101103524613305
Pubmed

TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.

HERC2 ARIH1 ZNF598

1.99e-0518103334729304
Pubmed

The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol.

INPP4A INPP4B

2.60e-053103210097090
Pubmed

Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.

TRIO KALRN

2.60e-053103231801062
Pubmed

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.

PRKN ULK1

2.60e-053103222275429
Pubmed

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.

PRKN ARIH1

2.60e-053103223707686
Pubmed

Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases.

PRKN ARIH1

2.60e-053103215963499
Pubmed

Phosphatidylinositol signalling reactions.

INPP4A INPP4B

2.60e-05310329599410
Pubmed

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

RNF168 UBE2Q1 CCDC57 KDM2A

3.11e-0560103420682791
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF536 ERC1 INPP4A ICE1 ZNF462 CEP131 CRYBG3 PCNT

3.58e-05418103834709266
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

USP53 TRIO ERC1 ACOT9 GOSR1 ANKRD26 CCDC57 CEP250 HERC2 ZNF598 PCNT

4.65e-058531031128718761
Pubmed

Network organization of the human autophagy system.

NSUN4 ERC1 GOSR1 GMPS BLOC1S5 ULK1 TRMT61B VTI1B

4.89e-05437103820562859
Pubmed

SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.

ERC1 CEP131

5.19e-054103227224062
Pubmed

Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.

PRKN ARIH1

5.19e-054103238386664
Pubmed

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.

PRKN ARIH1

5.19e-054103211278816
Pubmed

The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies.

PRKN ARIH1

5.19e-054103221590270
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ERC1 ZNF462 MACF1 KDM2A STK38L PCNT

5.81e-05225103612168954
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ELOA ZNF536 TUT4 TRIO GOSR1 SHC4 ICE1 RBM28 GGT7 CEP131

6.59e-057331031034672954
Pubmed

Assembly of high order G alpha q-effector complexes with RGS proteins.

TRIO KALRN

8.64e-055103218936096
Pubmed

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.

RNF168 HERC2

8.64e-055103222508508
Pubmed

Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.

UBE2Q1 HERC2

8.64e-055103222124266
Pubmed

The centriolar satellite protein Cep131 is important for genome stability.

CEP131 PCNT

8.64e-055103222797915
Pubmed

SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.

PRKN ULK1

8.64e-055103229330382
Pubmed

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

PRKN ULK1

8.64e-055103236608143
Pubmed

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

PRKN ARIH1

8.64e-055103224023840
Pubmed

Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein.

CHGB STMN3

8.64e-055103221852239
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

TRIO KALRN NBEA MACF1 CCDC136

8.97e-05151103517043677
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ELOA ERC1 MACF1 KDM2A TRMT61B SEPTIN10 PCNT

1.02e-04360103733111431
Pubmed

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

TRIO ANKRD26

1.29e-046103222666460
Pubmed

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

PRKN ARIH1

1.29e-046103221532592
Pubmed

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.

CEP131 PCNT

1.29e-046103224816561
Pubmed

Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.

ZNF224 ZNF256

1.29e-046103210585455
Pubmed

TRIM50 regulates Beclin 1 proautophagic activity.

TRIM50 ULK1

1.29e-046103229604308
Pubmed

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.

RNF168 HERC2

1.29e-046103220023648
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

KIF1A SSB RBM28 GMPS TTLL12 MACF1 HERC2 AQR PCNT

1.44e-04653103922586326
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

MED10 SFSWAP SSB ANKRD11 HERC2 AQR

1.55e-04269103629511261
Pubmed

A proteome-scale map of the SARS-CoV-2-human contactome.

ELOA KALRN CCDC57 CEP250 TRIM50

1.70e-04173103536217029
Pubmed

Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.

BBS9 ADCY8

1.81e-047103226480920
Pubmed

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

ZNF462 FSD1L

1.81e-047103219448620
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF168 PRKN HERC2 ARIH1

1.88e-0495103429643511
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

ELOA ERC1 CEP250 CEP131 TIMELESS PCNT

2.11e-04285103632838362
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ICE1 EFR3B KDM2A STK38L

2.47e-04102103410231032
Pubmed

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.

PRKN ARIH1

3.85e-0410103232246052
Pubmed

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.

PRKN ARIH1

3.85e-0410103227312108
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

TRIO ERC1 MACF1 CEP131 CRYBG3

4.06e-04209103536779422
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

KIF1A TRIO KALRN ERC1 CHD9 NBEA ZNF224 TTLL12 MACF1 DHX35 HERC2 PCNT

4.25e-0412851031235914814
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

TUT4 ZNF48 ZBTB48 ERC1 GOSR1 CHD9 STMN3 CEP131 ZNF598 COQ7

4.28e-049251031028986522
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

GOSR1 ZNF407 SSB ALG1L2 GMPS ULK1 PCNT

4.33e-04457103732968282
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

NSUN4 ACOT9 TTLL12 CEP131 ARIH1

4.33e-04212103533462405
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZNF48 TRIO KALRN ICE1 GGT7 POMGNT2 ANKRD11 CEP131 ULK1 HERC2 PCNT

4.40e-0411051031135748872
Pubmed

The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.

BBS9 CEP131

4.69e-0411103224550735
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NSUN4 ZNF48 SFSWAP KIF1A GOSR1 ICE1 TEKT5 ANKRD11 MACF1 CEP131 HERC2 ZNF598 AQR

4.83e-0414971031331527615
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

KIF1A KALRN CEP131 ARIH1 ZNF598

4.91e-04218103533378226
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

KIF1A TRIO KALRN INPP4A SSB A2ML1 HERC2

5.44e-04475103731040226
Pubmed

Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.

GOSR1 VTI1B

5.62e-0412103211927603
Pubmed

FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.

SSB GMPS

5.62e-0412103229142217
Pubmed

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.

CEP250 CEP131 PCNT

6.24e-0456103311076968
Pubmed

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.

CEP250 CEP131 PCNT

6.57e-0457103316462731
Pubmed

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection.

USP53 ZNF598

6.63e-0413103236379255
Pubmed

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

CEP250 CEP131 PCNT

6.91e-0458103312852856
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

TRIO KALRN ANKRD26 ZNF407 ZNF462 MACF1 KDM2A

7.10e-04497103723414517
Pubmed

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

CEP250 CEP131 PCNT

8.01e-046110337790358
Pubmed

The DNA sequence and comparative analysis of human chromosome 20.

MYH7B CHGB GGT7 STMN3 CEP250 DHX35 CFAP61

8.94e-04517103711780052
Pubmed

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

ANKRD26 CEP250 CEP131 PCNT

9.55e-04146103421399614
Pubmed

Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.

CEP250 CEP131 PCNT

1.01e-0366103312221128
Pubmed

TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.

ULK1 STK38L VTI1B

1.05e-0367103335670107
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ELOA TRIO ERC1 NBEA GMPS EFR3B CEP131 CRYBG3 HERC2 PCNT

1.12e-0310491031027880917
Pubmed

The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

ANKRD11 HERC2

1.15e-0317103223502783
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ELOA MYH7B ERC1 ANKRD26 CAGE1 CCDC57 RYR2 SCML4 MACF1 ULK1 SEPTIN10 PCNT

1.16e-0314421031235575683
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

KIF1A CCDC57 SEZ6L2 ANKRD11 PRKN CCDC136

1.28e-03402103624722188
Pubmed

Architectural niche organization by LHX2 is linked to hair follicle stem cell function.

MACF1 PCNT

1.29e-0318103224012369
Pubmed

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

ICE1 STK38L

1.29e-0318103220064376
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

KIF1A KALRN ZNF225 CCDC57 A2ML1 HERC2 MUC2

1.30e-03552103710737800
Pubmed

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

ELOA MED10 ICE1

1.35e-0373103321729782
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZNF536 ERC1 MACF1 ULK1 AQR PCNT

1.36e-03407103612693553
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ELOA NSUN4 MED10 SFSWAP KALRN CHD9 ZNF462 MACF1 DHX35 AQR

1.41e-0310821031038697112
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

TUT4 ERC1 ACOT9 ANKRD26 MACF1 KDM2A DHX35 ZNF598

1.42e-03724103836232890
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM51 TRIM51G

1.44e-0319103222144910
Pubmed

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.

CEP250 PCNT

1.44e-0319103224421332
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

SSB MACF1 HERC2

1.52e-0376103327542412
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

ZNF536 CHD9 SSB ZNF462 MACF1

1.55e-03282103523667531
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

ANKRD26 MACF1

1.59e-0320103221689717
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF224 ZNF225

1.59e-0320103212743021
Pubmed

Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.

GOSR1 VTI1B

1.59e-0320103229437892
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

RYR2 ANKRD11 PRKN CEP131

1.60e-03168103430631154
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

HERC2 ZNF598

1.76e-0321103237422473
Pubmed

A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

TRIO ZNF462

1.76e-0321103224025145
Pubmed

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.

INPP4B CEP131

1.76e-0321103224407287
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

ERC1 ACOT9 RBM28 CEP250 CEP131 HERC2 ZNF598 PCNT

1.83e-03754103833060197
Pubmed

Functional proteomics mapping of a human signaling pathway.

RNF168 INPP4A RYR2 CEP250 MACF1 KDM2A HERC2

1.92e-03591103715231748
Pubmed

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

CHGB BBS9 CCDC65

2.09e-0385103323055939
Pubmed

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

DOCK2 MAP3K14

2.11e-0323103222761313
InteractionNIN interactions

TRIO ERC1 ACOT9 ANKRD26 CCDC57 CEP250 DHX35 CEP131 HERC2 SEPTIN10 ZNF598 PCNT

2.73e-0735910212int:NIN
InteractionNINL interactions

USP53 ELOA ERC1 ANKRD26 SSB CCDC57 CEP250 A2ML1 DHX35 CEP131 ZNF598 PCNT

3.49e-0645810212int:NINL
InteractionNDC80 interactions

ERC1 ANKRD26 CAGE1 ICE1 CCDC57 CEP250 CEP131 HERC2 CCDC136 PCNT

4.15e-0631210210int:NDC80
InteractionHERC2 interactions

MED10 RNF168 SFSWAP INPP4A SSB CEP250 MACF1 HERC2 CCDC65 ODAD3 CCDC136 AQR

9.04e-0650310212int:HERC2
InteractionPCM1 interactions

RNF168 ERC1 ACOT9 ANKRD26 CCDC57 CEP250 CEP131 HERC2 SEPTIN10 CCDC65 PCNT

1.25e-0543410211int:PCM1
InteractionDTNBP1 interactions

KALRN NBEA BLOC1S5 MACF1 PRKN VTI1B PCNT

1.85e-051621027int:DTNBP1
InteractionCFAP61 interactions

PRKN CFAP61

2.54e-0521022int:CFAP61
InteractionMAPRE1 interactions

KIF1A TRIO ERC1 ANKRD26 ARHGEF16 CEP250 MACF1 CEP131 HERC2 ZNF598 PCNT

5.87e-0551410211int:MAPRE1
InteractionODAD3 interactions

PRKN HERC2 ODAD3 CCDC136

5.97e-05421024int:ODAD3
Cytoband20q11.22

MYH7B GGT7 CEP250

8.06e-0537103320q11.22
Cytoband1p36.3

ZBTB48 ARHGEF16

4.46e-041410321p36.3
GeneFamilyGlycosyl transferases group 1 domain containing

ALG1L2 PIGA

7.68e-0410762427
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF536 ZNF48 ZBTB48 ZNF407 ZNF224 ZNF225 ZNF462 PRDM10 ZNF256 ZNF598

8.19e-04718761028
GeneFamilySNAREs|BCL2 homology region 3 (BH3) only

GOSR1 VTI1B

1.77e-03157621124
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO KALRN ARHGEF16

2.70e-0366763722
CoexpressionGSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP

DOCK2 ZNF407 NBEA GSAP BBS9 SKAP1 HERC2 PCNT

1.06e-061971028M7403
ToppCellNeuroendocrine-neuroendo-2-Calca|World / Class top

KIF1A CHGB TEKT5 SEZ6L2 SCML4 STMN3 SKAP1

2.91e-0718910376baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCellNeuroendocrine|World / Class top

KIF1A CHGB TEKT5 SEZ6L2 SCML4 STMN3 SKAP1

3.24e-0719210370199da3ef9ddb6673e9aa41f346f374838aec182
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 KIF1A SHC4 SLITRK3 GSAP ARHGEF16

5.02e-061881036c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 KIF1A SHC4 SLITRK3 GSAP ARHGEF16

5.02e-0618810363b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCellproximal-Hematologic-Natural_Killer_T-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK2 RBM28 SCML4 GOLGA8IP STMN3 CCDC136

6.19e-0619510364d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCellproximal-3-Hematologic-Natural_Killer_T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK2 RBM28 SCML4 GOLGA8IP STMN3 CCDC136

6.19e-06195103693093545bb23d2619ace029a52cffa1f673a0c2a
ToppCellproximal-Hematologic-Natural_Killer_T|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK2 RBM28 SCML4 GOLGA8IP STMN3 CCDC136

6.19e-0619510363944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell(08)_PNEC|World / shred by cell type and Timepoint

KIF1A CHGB TEKT5 SEZ6L2 SCML4 STMN3

6.37e-0619610362ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCellLPS-antiTNF-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 CAGE1 SCML4 SKAP1 SLC4A10

7.17e-0611510353ab39d28717ae585d84c0e0686508faab2fc2e3b
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

TUT4 INPP4B SCML4 STMN3 MACF1

2.68e-051511035999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBTB48 POMGNT2 CEP131 ODAD3 PCNT

3.43e-0515910357c2f70a7cba880115ccd676fb6c5f18488a5b74f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SHC4 ZNF407 INPP4B TTLL12 HERC2

3.64e-0516110355fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TUT4 ZNF407 INPP4B MACF1 ARIH1

4.85e-0517110352e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF1A CHGB SEZ6L2 STMN3 CCDC136

5.41e-0517510358362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF1A CHGB SEZ6L2 STMN3 CCDC136

5.41e-0517510358b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A CHGB SEZ6L2 STMN3 CCDC136

5.86e-05178103530ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHGB SEZ6L2 PRR19 CFAP61 CCDC136

6.18e-0518010359db9899ca42455310e9b63df523fe6c4780abfb7
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-CD8_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

INPP4B SCML4 STMN3 SKAP1 CCDC65

6.51e-05182103598c26ad34e01c4b8997d26d5d28a9935491295fa
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUT4 CHD9 ANKRD11 MACF1 AQR

6.86e-0518410351154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH7B INPP4B RYR2 PRKN CFAP61

7.04e-051851035549eeb521c3985bff396ea0f202db21822efa51f
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 KIF1A SHC4 SLITRK3 ARHGEF16

7.04e-05185103511c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF48 KIF1A CHGB SEZ6L2 STMN3

7.22e-051861035f5468e03321ea2083e223eb0d92c3a9307039569
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

KALRN INPP4B RYR2 MACF1 STK38L

7.59e-05188103534e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

MYH7B INPP4B RYR2 PRKN CFAP61

7.98e-051901035de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TUT4 INPP4B SCML4 STMN3 SKAP1

8.18e-051911035d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

INPP4B SKAP1 MACF1 KDM2A ARIH1

8.38e-05192103547646d7e4990be85072987f92bf18d52f8da752e
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO ERC1 ANKRD11 MACF1 PRKN

8.38e-051921035e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell10x3'2.3-week_12-13-Lymphocytic_T-T_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TUT4 INPP4B SCML4 STMN3 SKAP1

8.59e-05193103552b2181adcc8c0752a83d5ba7dfc540f13225fd6
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

INPP4B RYR2 PRKN CFAP61 STK38L

8.59e-051931035dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellCOVID-19-lung-CD8+_T_cells|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 INPP4B SCML4 SKAP1 SLC4A10

8.59e-051931035780e23e2705fc5c1b70e37568b79731ced5038bd
ToppCell10x3'2.3-week_12-13-Lymphocytic_T|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TUT4 INPP4B SCML4 STMN3 SKAP1

8.59e-0519310351b3a01fd6eb82f425c979a02d72fc37d948a360d
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

MYH7B INPP4B RYR2 PRKN CFAP61

9.01e-05195103575fc81bddb246dca3b437fb60827b1d4fe416405
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A NBEA SEZ6L2 ANKRD11 MACF1

9.01e-0519510353e519cffa6144a62b06124642a14c9ff39b76554
ToppCell(1)_T_cells-(1)_T_CD4_naive|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

TUT4 ERC1 ANKRD26 STMN3 ANKRD11

9.01e-051951035d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A NBEA SEZ6L2 ANKRD11 MACF1

9.01e-0519510357796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfrontal_cortex-Neuronal|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KIF1A CHGB STMN3 GNB5 SLC4A10

9.23e-051961035de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF536 KALRN INPP4B RYR2 STK38L

9.46e-051971035bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

INPP4A CCDC57 SCML4 SKAP1 SLC4A10

9.46e-051971035aa160ebf2f1913b83e0b1ae1de1d9e2089342948
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

KIF1A KALRN CHGB SEZ6L2 STMN3

9.46e-051971035c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCellMild_COVID-19-T/NK-CD4+_T_1|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

INPP4B SCML4 STMN3 SKAP1 SLC4A10

9.46e-05197103598fca0a2e2f66525c5c9d6cdaebcad14b4d53da4
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

KIF1A KALRN CHGB SEZ6L2 STMN3

9.46e-0519710352d92b0483d57541aee382dda80e42cf66e813d6b
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

USP53 ZNF225 INPP4B SCML4 MACF1

9.69e-051981035ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF407 SCML4 SLFN13 ANKRD11 MACF1

9.92e-051991035f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

INPP4A GSAP SLFN13 SKAP1 MACF1

9.92e-051991035df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

INPP4A GSAP SLFN13 SKAP1 MACF1

9.92e-051991035ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF536 KIF1A SHC4 POMGNT2 A2ML1

9.92e-0519910354e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 CHGB SCML4 SKAP1 SLC4A10

9.92e-051991035036776a03fdd181e51cc655ed99331eec9c63f39
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-CD8+_Tcm|Int-URO / Disease, condition lineage and cell class

INPP4B SCML4 STMN3 SKAP1 GNB5

1.02e-0420010359535fd16a962d57e80319bc26093617e04c8b2a8
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 INPP4B SCML4 PRR19 SKAP1

1.02e-04200103520ffb3436d08042f77800513e6ddb3bbc38ae6fe
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 KIF1A SHC4 NBEA STMN3

1.02e-042001035553e9612874480f4d2a45671462e266cd0a09321
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B0|356C / Donor, Lineage, Cell class and subclass (all cells)

SHC4 CAGE1 SLFN13 CCDC65

2.88e-041371034fec21e7a25241289b18aea6a46dc2b981438ebe6
ToppCellLPS-IL1RA-Hematopoietic_Mast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 INPP4B SCML4 SKAP1

3.30e-041421034f7d0d5ca9fc3dd929d4fdd59b71bfa623007e992
ToppCellLPS-IL1RA-Hematopoietic_Mast-Mast_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 INPP4B SCML4 SKAP1

3.30e-0414210342a9a070e7c53ac593d46c6c5f6983f07d4413501
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 INPP4B SCML4 SKAP1

3.67e-041461034a5c84ad44d6ffb25028a4fd5454fd5de81b16a5e
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 INPP4B SCML4 SKAP1

3.67e-0414610348133037881c15e75637fc616091a7055488dd5fc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UBE2Q1 ALG1L2 POMGNT2 VTI1B

3.76e-041471034f703cb0330304799d16e457215269c7732c9d5d5
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CAGE1 SLFN13 STMN3 PRKN

3.86e-04148103410dcbdb47cac908648d9d652c8095b536db19b8a
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CHGB TEKT5 INPP4B SKAP1

3.96e-0414910348638b3819193d11411df58964069fec583f617f4
ToppCellMS-CD4-CD8_1|MS / Condition, Cell_class and T cell subcluster

CAGE1 PRDM10 PRR19 ZNF256

4.06e-0415010347dc95c58b98d8c4c6c49fb1a03ec6ac24fb41f54
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GGT7 SKAP1 PRKN CCDC136

4.06e-041501034973252f4de9a1194aea9f3cb0e1f113643f16c91
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 INPP4B SCML4 SKAP1

4.16e-041511034b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|343B / Donor, Lineage, Cell class and subclass (all cells)

CAGE1 SKAP1 TRMT61B COQ7

4.16e-04151103478475027bba9e3026e42493fec8ea630972353bb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

INPP4A CHGB SCML4 PCNT

4.27e-0415210345adcdf93fd3ca066402aaaf308c363e4648f871d
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

BBS9 STMN3 SKAP1 ZNF256

4.27e-041521034669d8f12fdb110ed72f4e5348b7b5350144a061c
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GSAP SCML4 SLFN13 SKAP1

4.38e-041531034d8773ee16c7d3e0834b9f64054d42336d6f9833b
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

CHGB INPP4B SCML4 A2ML1

4.49e-0415410345ff380205fa7ab97ba21f6512bc9e14c0fb320b6
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ELOA TUT4 ICE1 MACF1

4.60e-0415510340a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|368C / Donor, Lineage, Cell class and subclass (all cells)

MRAS INPP4A RBM28 PRDM10

4.71e-04156103425b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP3K14 SLFN13 VSIG10L CFAP61

4.82e-0415710344766f7d545bf2d775390589460677519cb92f4d5
ToppCellsevere_influenza-CD4+_T_naive|World / disease group, cell group and cell class (v2)

INPP4B SCML4 ZNF462 STMN3

4.94e-0415810348ab3d8a9b7a1daa890d76dde1d6182af40b70021
ToppCellInt-URO-Lymphocyte-T_NK-CD8_TCM|Int-URO / Disease, Lineage and Cell Type

SCML4 STMN3 SKAP1 GNB5

4.94e-041581034edcc5a26d4571b179f3ae538fed23b661e4677dd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD26 INPP4B SCML4 STMN3

5.06e-041591034b9d34b9ed8db798f5ea93c44b469cae499403cb8
ToppCellfacs-Marrow-T-cells-24m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8 SCML4 PRDM10 PRR19

5.18e-041601034b3f7ef7e682b48a83ca425f5c439336e96168300
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

KALRN INPP4B RYR2 A2ML1

5.30e-04161103464891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCellHealthy_Control-Myeloid-Macrophages-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

INPP4B RYR2 SCML4 SKAP1

5.30e-041611034d0482666479530cd2fd0d229cbb59a1d79839477
ToppCellURO-Lymphocyte-T_NK-CD4_CTL|URO / Disease, Lineage and Cell Type

SHC4 RYR2 SCML4 SKAP1

5.43e-0416210341afeeb17e263cf625a4f285203cf82f973735193
ToppCellCOVID-19_Mild-PLT_0|COVID-19_Mild / Disease Group and Platelet Clusters

ANKRD26 ICE1 VSIG10L MACF1

5.81e-041651034083a14d3b0162cee4e79f7398b8fb739582b39ff
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD8-Tem/emra_CD8|GI_large-bowel / Manually curated celltypes from each tissue

KIF1A NBEA ARHGEF16 SEZ6L2

5.95e-04166103413bef304ea3df8e8d2bc376a3287c78220a1b0c6
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYP2C8 CHGB SEZ6L2 CFAP61

5.95e-041661034f0912ce0df5ede3bc5e7c99ccfe4decc16c6064e
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CYP2C8 SEZ6L2 GGT7 ZNF462

5.95e-04166103489e2b8453180983533faccb4275867861876d7ee
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH7B CHGB SEZ6L2 PRKN

6.08e-041671034b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

KALRN BBS9 ZNF462 SKAP1

6.22e-04168103445ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF407 BCLAF3 POMGNT2 EFR3B

6.36e-041691034665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF407 BCLAF3 POMGNT2 EFR3B

6.36e-0416910346614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

STMN3 SKAP1 VSIG10L CEP131

6.65e-0417110343b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell368C-Lymphocytic-ILC-ILC-2|368C / Donor, Lineage, Cell class and subclass (all cells)

STMN3 SKAP1 VSIG10L CEP131

6.65e-041711034fd01076574dcc82bfd4a1538812500543b16794f
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ELOA TUT4 ICE1 MACF1

6.65e-041711034d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

INPP4B TTLL12 SKAP1 ZNF598

6.65e-041711034f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|367C / Donor, Lineage, Cell class and subclass (all cells)

CAGE1 SLFN13 PRKN CCDC136

6.79e-0417210346379ae0aca9007c3a8a87e3330908fc90961ad3f
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK2 USP53 SKAP1 GNB5

6.79e-04172103430f4979abf0218618a56afb06aa6afc23ad838ec
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEZ6L2 SCML4 EFR3B TIMELESS

6.94e-04173103466488d01e03264fb193285470901c9c4182fbae8
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

ZNF536 KALRN INPP4B RYR2

6.94e-041731034a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

KALRN INPP4B RYR2 DCLK3

6.94e-0417310345416b092321c7d9b63f0418c60f2402a138355bf
ToppCellTuft-tuft-4|World / Class top

KALRN RNASEL PIGA DHX35

7.09e-041741034d6f306ebf66061bf9e9742000bfedce12d277452
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSAP INPP4B SCML4 SKAP1

7.09e-0417410341c073177c1753e3b91ef8fd9e95230a1d13c82f3
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

INPP4B SCML4 SLC4A10 MUC2

7.09e-0417410345e6050d20a5b27640f6a200441125b8ceba123c8
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

TUT4 ZNF224 PIGA COQ7

7.09e-0417410342274648b80dd74f3c948a779bba3391095964c34
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSAP INPP4B SCML4 SKAP1

7.09e-0417410345491ad5c144baf2ef9b1c58eb720c872d14feb15
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK2 CCDC57 SCML4 SLFN13

7.25e-041751034f2c3e0f728a43d6988e793c8a50c964f7447db82
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ALG1L2 INPP4B POMGNT2 COQ7

7.40e-041761034ac83a6cd4bcbb9ca1fc02a9fbd9d9629ef1df8ca
Diseasepost-operative stroke, response to surgery

BBS9 RYR2

1.11e-045992EFO_0009951, EFO_0009956
Diseasemammographic density percentage

NBEA ADCY8 FUT2

1.26e-0429993EFO_0006502
DiseaseIntellectual Disability

TRIO ACOT9 INPP4A NBEA RBM28 ZNF462 SLC4A10 MACF1

1.34e-04447998C3714756
Diseasebringing up phlegm, sputum or mucus on most days, self-reported

FUT2 MUC2

3.95e-049992EFO_0009824
Diseasebreast milk measurement

KALRN GOSR1 INPP4B FUT2

4.56e-04106994EFO_0009092
Diseasecomparative body size at age 10, self-reported

ZNF536 MRAS ZBTB48 BBS9 ADCY8 ZNF462 FUT2

5.45e-04420997EFO_0009819
DiseaseBardet-Biedl syndrome (implicated_via_orthology)

BBS9 CEP131

6.01e-0411992DOID:1935 (implicated_via_orthology)
Diseaseocular hypertension, response to triamcinolone acetonide

CHD9 TIMELESS CFAP61

6.03e-0449993EFO_0006954, EFO_1001069
Diseasemammographic density measurement

NBEA ADCY8 FUT2

6.40e-0450993EFO_0005941
DiseasePROSTATE CANCER, HEREDITARY, 1

DOCK2 RNASEL KDM2A

1.09e-0360993C4722327
Diseasesexual dimorphism measurement

KIF1A GOSR1 SEZ6L2 ADCY8 GGT7 ZNF462 CEP250 EFR3B ANKRD11 MACF1 KDM2A

1.21e-0311069911EFO_0021796
Diseaserespiratory symptom change measurement, response to placebo

BBS9 ADCY8

1.47e-0317992EFO_0008344, EFO_0010068
Diseasesquamous cell carcinoma

ANKRD11 PRKN HERC2

1.50e-0367993EFO_0000707
DiseaseProstate cancer, familial

DOCK2 RNASEL KDM2A

1.63e-0369993C2931456
Diseaseskin sensitivity to sun

ANKRD11 HERC2

1.84e-0319992EFO_0004795
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

MRAS A2ML1

1.84e-0319992C3501846
Diseaseblood metabolite measurement

NAT8 GMPS

1.84e-0319992EFO_0005664
DiseaseCostello syndrome (disorder)

MRAS A2ML1

1.84e-0319992C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

MRAS A2ML1

1.84e-0319992C1843181
DiseaseCardio-facio-cutaneous syndrome

MRAS A2ML1

1.84e-0319992C1275081
DiseaseCraniosynostosis

BBS9 ZNF462

2.04e-0320992C0010278
DiseaseLEOPARD Syndrome

MRAS A2ML1

2.46e-0322992C0175704
DiseaseNoonan Syndrome

MRAS A2ML1

2.93e-0324992C0028326
DiseaseAutism Spectrum Disorders

SFSWAP RYR2 ANKRD11

2.96e-0385993C1510586
Diseaseresponse to peginterferon alfa-2a

ANKRD26 PRKN

3.18e-0325992EFO_0010103

Protein segments in the cluster

PeptideGeneStartEntry
EEGHGKERNEFLRKH

ADCY8

566

P40145
PQLHVRKARVEDHDD

CFAP61

181

Q8NHU2
IAHLEERNKHLEDLI

CAGE1

726

Q8TC20
DEKERHRDRHADGLL

ANKRD11

1471

Q6UB99
IKDLGEIHSRLLDHR

BLOC1S5

36

Q8TDH9
DHHEDGIKREREIFS

CRYBG3

161

Q68DQ2
LHELVKHEENRLVFE

ALG1L2

181

C9J202
EEKHFLRLHLENRVE

CCDC65

206

Q8IXS2
IRVRGHDDSFLKNHL

A2ML1

361

A8K2U0
EEKLLGHRFHSELRL

ARHGEF16

11

Q5VV41
AKVQEEIDHVIGRHR

CYP2C8

321

P10632
KQGIFHIHEVRDKLR

ACOT9

31

Q9Y305
IDERHLLRLGHGEEE

AQR

871

O60306
LEIEFHHTRDALREK

ANKRD26

1076

Q9UPS8
EHVDRFHQLILRVKD

MRAS

101

O14807
EFQEHEHALKALRLI

RBM28

546

Q9NW13
HAEHERQAKELFLLR

ERC1

271

Q8IUD2
QRRGLQVALEEFHKH

RARRES2

26

Q99969
ERAKLHDVELHQVAE

GNB5

71

O14775
GTFIVKDLLQDRHHR

INPP4A

136

Q96PE3
RRVLLQHVHEGYEKD

ARIH1

536

Q9Y4X5
ELFLKEHDHLRNSDR

GOSR1

161

O95249
REDLHILFSNHGEIK

SSB

246

P05455
EHLDRFNHLAPGKER

HERC2

1166

O95714
PEEDNKIDHFILEHR

FSD1L

221

Q9BXM9
LRDEHQLHKDFFIRA

INPP4B

861

O15327
EATLEERHARGEKHL

DCLK3

111

Q9C098
ERHARGEKHLGVEIE

DCLK3

116

Q9C098
FRLRHGHEEALEALE

MYH7B

1531

A7E2Y1
IEFLEARGHHVEKVD

GGT7

616

Q9UJ14
LEDKHRVVIQRDEGH

MUC2

931

Q02817
EILISFIDRHGNRHK

EFR3B

476

Q9Y2G0
HRARALQKRHDDFEE

KALRN

571

O60229
KHVRLREHAATLEEE

POMGNT2

21

Q8NAT1
EKDKLDQHLRFHGRE

PRDM10

541

Q9NQV6
DHLEEHLEKFVENIR

MED10

6

Q9BTT4
HELELLREQHAREKE

PCNT

301

O95613
HHFELRINGEKLEEL

BBS9

651

Q3SYG4
RKHINDLYEDLRDGH

MACF1

96

Q9UPN3
DRHSLHEEENNIFKR

NSUN4

261

Q96CB9
VSELKDHFLRHLQGV

GSAP

611

A4D1B5
HGRFKRQLNEHDVEI

CHD9

1516

Q3L8U1
VSGHFHRLSRELEKE

ICE1

581

Q9Y2F5
HHNDTELIRKLREEG

GMPS

391

P49915
RKDRQVHLTHFELEG

KDM2A

446

Q9Y2K7
RRKERLQNEDEHIFH

BCLAF3

561

A2AJT9
IHEKRVSDNLRPFHD

DOCK2

1586

Q92608
LRKHEHVGSFARDLV

ELOA

81

Q14241
HDHVREEAQKFLRGL

FUT2

171

Q10981
AIRVHRKFAVEEGDH

DHX35

531

Q9H5Z1
IKKFRDEELEHHDIG

COQ7

171

Q99807
ERHGELQDHKEQARR

CEP250

1856

Q9BV73
EHRLELERVHSDKNG

CCDC57

126

Q2TAC2
ILLDQHRRKFGERHI

PIWIL3

161

Q7Z3Z3
EEKRFLGEGHHRVQE

CHGB

436

P05060
PDEHLEHEDKQNRLR

RYR2

466

Q92736
RETFLREKFEHIQHI

SLFN13

651

Q68D06
AVKRADHLEELLEQH

CEP131

1061

Q9UPN4
RQDIVLSGHFIKEEH

KIF1A

526

Q12756
EHLHIREFHRVKVGD

MAP3K14

871

Q99558
DHKILIDRYDGRGHL

SFSWAP

66

Q12872
IDAIHQLGFIHRDIK

STK38L

201

Q9Y2H1
SLIKELHHFRILGEE

PRKN

296

O60260
TGQALEHLDHRLREK

ODAD3

146

A5D8V7
EFILNRQRAEDVHKH

NBEA

1986

Q8NFP9
HFHGKDLREIRKTEL

SLITRK3

266

O94933
DEETKDLIHRLFHPG

RNASEL

556

Q05823
HREKRIGIDLVHDNV

TEKT5

196

Q96M29
EAAEGRRLHLHFERV

SEZ6L2

381

Q6UXD5
REHEREVLHKALEEN

STMN3

111

Q9NZ72
EIHEELRRFKESHFQ

CCDC136

641

Q96JN2
QHHLEGFRKELRNLE

USP53

746

Q70EK8
HDRVRLLGALEHKDV

PIGA

281

P37287
RTKDHVFDNVGHLIR

SHC4

581

Q6S5L8
ELQLHEAFKHRGEKL

ZBTB48

421

P10074
GERDLIFHKGLHNLR

TIMELESS

291

Q9UNS1
EFARGSDLVKHLRVH

ZNF48

311

Q96MX3
QGRVISFEVRKDHHD

TRMT61B

271

Q9BVS5
REHRGLFNHEVKSLD

PRR19

71

A6NJB7
HEEEQHHLERLRKEG

TRIM51

191

Q9BSJ1
HHLERLRKEGEDIFQ

TRIM51

196

Q9BSJ1
EFLEEKLGHRHGIDI

SPATA31D1

1411

Q6ZQQ2
RKFDLIVHERVHTGE

ZNF256

446

Q9Y2P7
HFEKEDLEGHRTLFI

SLC4A10

36

Q6U841
KRHEFHGERQRKEEE

SEPTIN10

351

Q9P0V9
RLLHKLEHEVFDAGE

TTLL12

51

Q14166
DLEHLLFERHKQEEQ

RNF168

431

Q8IYW5
RVHKRDRKGEEDGLH

ZNF536

651

O15090
LDLDFHQRVHRGEKP

ZNF225

441

Q9UK10
LREHFREKHFLCEEG

ZNF598

231

Q86UK7
HEEEQRHLERLQKEG

TRIM51G

191

A0A3B3IT33
HLRDEHKVSRNFELV

ZNF462

2346

Q96JM2
LFLHIKGQHEELLRE

ZNF407

1501

Q9C0G0
HRDHLRFDQARGVLE

VSIG10L

251

Q86VR7
LDLDFHQRVHTGEKL

ZNF224

441

Q9NZL3
GLKQAEERLERDHIF

TUT4

276

Q5TAX3
RREFQELHHLVDEEK

TRIM50

176

Q86XT4
FEKLHEIFRGLHEDL

VTI1B

11

Q9UEU0
HVELFRKHEIDGNAL

SCML4

366

Q8N228
DHRDHILRGFQQIKA

SKAP1

36

Q86WV1
FKGRHREKHDLEVAV

ULK1

31

O75385
HRARALQKRHEDFEE

TRIO

601

O75962
KLLESIFHRGHERFR

UBE2Q1

46

Q7Z7E8
LERHEYAEHLKGERA

GOLGA8IP

236

A6NC78
HLFVDSEHRRQGIAK

NAT8

141

Q9UHE5