Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cobalamin binding	TCN1 CUBN	2.84e-04	10	51	2	GO:0031419
GeneOntologyMolecularFunction	hemoglobin binding	LRP2 CUBN	3.47e-04	11	51	2	GO:0030492
GeneOntologyMolecularFunction	complement component C3b binding	CFHR1 CFHR2	4.15e-04	12	51	2	GO:0001851
GeneOntologyBiologicalProcess	cobalamin transport	TCN1 LRP2 CUBN	1.69e-06	10	51	3	GO:0015889
GeneOntologyBiologicalProcess	endocytic hemoglobin import into cell	LRP2 CUBN	5.99e-06	2	51	2	GO:0020028
GeneOntologyBiologicalProcess	positive regulation of cytokine production	USP50 TRIM16 CD4 PRG3 PRG2 C5 CEACAM20 CD200	8.78e-05	586	51	8	GO:0001819
GeneOntologyCellularComponent	cell surface	CD4 CSF3R PDGFRA IQGAP2 ENTPD2 LRP2 ABCB11 CUBN CEACAM20 CD163 CD200	7.35e-05	1111	52	11	GO:0009986
GeneOntologyCellularComponent	endocytic vesicle membrane	CD4 CSF3R LRP2 CUBN CD163	1.81e-04	212	52	5	GO:0030666
GeneOntologyCellularComponent	microvillus	PDGFRA IQGAP2 CUBN CEACAM20	2.48e-04	123	52	4	GO:0005902
GeneOntologyCellularComponent	brush border	TMPRSS15 LRP2 ACTN3 CUBN	5.55e-04	152	52	4	GO:0005903
GeneOntologyCellularComponent	lysosomal membrane	CSF3R LRP2 ZFYVE26 LRBA CUBN VPS13B	9.71e-04	462	52	6	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	CSF3R LRP2 ZFYVE26 LRBA CUBN VPS13B	9.71e-04	462	52	6	GO:0098852
GeneOntologyCellularComponent	vacuolar membrane	CSF3R LRP2 ZFYVE26 LRBA CUBN VPS13B	1.56e-03	507	52	6	GO:0005774
GeneOntologyCellularComponent	external side of plasma membrane	CD4 CSF3R PDGFRA LRP2 CUBN CD163	1.76e-03	519	52	6	GO:0009897
GeneOntologyCellularComponent	P-body	SYNE1 TNRC6C SAMD4A	2.10e-03	102	52	3	GO:0000932
GeneOntologyCellularComponent	midbody	USP50 SYNE1 ZFYVE26 CEP126	2.25e-03	222	52	4	GO:0030496
GeneOntologyCellularComponent	cluster of actin-based cell projections	TMPRSS15 LRP2 ACTN3 CUBN	2.29e-03	223	52	4	GO:0098862
GeneOntologyCellularComponent	endocytic vesicle	CD4 CSF3R LRP2 CUBN CD163	2.61e-03	384	52	5	GO:0030139
HumanPheno	Abnormal intestine morphology	CFHR1 KIFBP TMPRSS15 MYLK PDGFRA SYNE1 SETBP1 EHMT1 LRP2 ABCB11 GRB10 ZFYVE26 C5 LRBA CUBN DNASE2 RYR3	8.56e-06	1459	23	17	HP:0002242
Domain	EMBP_CTLD	PRG3 PRG2	7.60e-06	2	52	2	IPR033816
Domain	Eosinophil_major_basic	PRG3 PRG2	7.60e-06	2	52	2	IPR002352
Domain	CUB	TMPRSS15 CUBN CSMD1 CSMD3	1.03e-05	49	52	4	PF00431
Domain	CUB	TMPRSS15 CUBN CSMD1 CSMD3	1.12e-05	50	52	4	SM00042
Domain	-	TMPRSS15 CUBN CSMD1 CSMD3	1.31e-05	52	52	4	2.60.120.290
Domain	Sushi	CFHR1 CFHR2 CSMD1 CSMD3	1.31e-05	52	52	4	PF00084
Domain	CUB	TMPRSS15 CUBN CSMD1 CSMD3	1.41e-05	53	52	4	PS01180
Domain	CCP	CFHR1 CFHR2 CSMD1 CSMD3	1.52e-05	54	52	4	SM00032
Domain	SUSHI	CFHR1 CFHR2 CSMD1 CSMD3	1.76e-05	56	52	4	PS50923
Domain	Sushi_SCR_CCP_dom	CFHR1 CFHR2 CSMD1 CSMD3	1.89e-05	57	52	4	IPR000436
Domain	CUB_dom	TMPRSS15 CUBN CSMD1 CSMD3	1.89e-05	57	52	4	IPR000859
Domain	ConA-like_dom	TRIM16 TMPRSS15 LRBA PTPRU RYR3	3.52e-04	219	52	5	IPR013320
Domain	Ig-like_dom	CD4 MYLK CSF3R PDGFRA PTPRU CEACAM20 CD200	4.62e-04	503	52	7	IPR007110
Domain	CH	IQGAP2 SYNE1 ACTN3	7.87e-04	65	52	3	SM00033
Domain	MAM_1	TMPRSS15 PTPRU	8.90e-04	16	52	2	PS00740
Domain	CH	IQGAP2 SYNE1 ACTN3	9.77e-04	70	52	3	PF00307
Domain	MAM	TMPRSS15 PTPRU	1.01e-03	17	52	2	SM00137
Domain	-	IQGAP2 SYNE1 ACTN3	1.02e-03	71	52	3	1.10.418.10
Domain	IG	CD4 MYLK PDGFRA PTPRU CEACAM20 CD200	1.07e-03	421	52	6	SM00409
Domain	Ig_sub	CD4 MYLK PDGFRA PTPRU CEACAM20 CD200	1.07e-03	421	52	6	IPR003599
Domain	CH	IQGAP2 SYNE1 ACTN3	1.10e-03	73	52	3	PS50021
Domain	MAM	TMPRSS15 PTPRU	1.13e-03	18	52	2	PF00629
Domain	MAM_dom	TMPRSS15 PTPRU	1.13e-03	18	52	2	IPR000998
Domain	MAM_2	TMPRSS15 PTPRU	1.13e-03	18	52	2	PS50060
Domain	CH-domain	IQGAP2 SYNE1 ACTN3	1.19e-03	75	52	3	IPR001715
Domain	WD40_repeat_dom	NWD1 TBL1Y UBR4 GEMIN5 LRBA	1.39e-03	297	52	5	IPR017986
Domain	Apc4_WD40_dom	NWD1 GEMIN5	1.40e-03	20	52	2	IPR024977
Domain	ANAPC4_WD40	NWD1 GEMIN5	1.40e-03	20	52	2	PF12894
Domain	SRCR	TMPRSS15 CD163	1.54e-03	21	52	2	PF00530
Domain	Actinin_actin-bd_CS	SYNE1 ACTN3	1.85e-03	23	52	2	IPR001589
Domain	Spectrin	SYNE1 ACTN3	1.85e-03	23	52	2	PF00435
Domain	ACTININ_2	SYNE1 ACTN3	1.85e-03	23	52	2	PS00020
Domain	ACTININ_1	SYNE1 ACTN3	1.85e-03	23	52	2	PS00019
Domain	ig	CD4 PDGFRA CEACAM20 CD200	1.92e-03	190	52	4	PF00047
Domain	Immunoglobulin	CD4 PDGFRA CEACAM20 CD200	1.92e-03	190	52	4	IPR013151
Domain	SR	TMPRSS15 CD163	2.19e-03	25	52	2	SM00202
Domain	-	TMPRSS15 CD163	2.19e-03	25	52	2	3.10.250.10
Domain	-	CD4 MYLK CSF3R PDGFRA PTPRU CEACAM20 CD200	2.30e-03	663	52	7	2.60.40.10
Domain	IG_LIKE	CD4 MYLK PDGFRA PTPRU CEACAM20 CD200	2.34e-03	491	52	6	PS50835
Domain	SRCR_1	TMPRSS15 CD163	2.37e-03	26	52	2	PS00420
Domain	SRCR_2	TMPRSS15 CD163	2.37e-03	26	52	2	PS50287
Domain	SRCR-like_dom	TMPRSS15 CD163	2.37e-03	26	52	2	IPR017448
Domain	ARM-type_fold	ZYG11A UBR4 ZYG11B LRBA RYR3	2.47e-03	339	52	5	IPR016024
Domain	SRCR	TMPRSS15 CD163	2.55e-03	27	52	2	IPR001190
Domain	Spectrin_repeat	SYNE1 ACTN3	2.94e-03	29	52	2	IPR002017
Domain	UBA	UBAC1 TNRC6C	3.15e-03	30	52	2	SM00165
Domain	Ig-like_fold	CD4 MYLK CSF3R PDGFRA PTPRU CEACAM20 CD200	3.26e-03	706	52	7	IPR013783
Domain	Spectrin/alpha-actinin	SYNE1 ACTN3	3.57e-03	32	52	2	IPR018159
Domain	SPEC	SYNE1 ACTN3	3.57e-03	32	52	2	SM00150
Domain	IGc2	CD4 MYLK PDGFRA CEACAM20	4.12e-03	235	52	4	SM00408
Domain	Ig_sub2	CD4 MYLK PDGFRA CEACAM20	4.12e-03	235	52	4	IPR003598
Domain	UBA	UBAC1 TNRC6C	4.51e-03	36	52	2	PF00627
Domain	LDLR_class-A_CS	TMPRSS15 LRP2	5.54e-03	40	52	2	IPR023415
Domain	WD40	NWD1 TBL1Y GEMIN5 LRBA	5.81e-03	259	52	4	PF00400
Domain	C-type_lectin_CS	PRG3 PRG2	6.38e-03	43	52	2	IPR018378
Domain	WD40	NWD1 TBL1Y GEMIN5 LRBA	6.54e-03	268	52	4	SM00320
Domain	UBA	UBAC1 TNRC6C	6.67e-03	44	52	2	IPR015940
Domain	WD40_repeat	NWD1 TBL1Y GEMIN5 LRBA	6.89e-03	272	52	4	IPR001680
Domain	Ldl_recept_a	TMPRSS15 LRP2	6.97e-03	45	52	2	PF00057
Domain	-	TMPRSS15 LRP2	7.28e-03	46	52	2	4.10.400.10
Domain	WD_REPEATS_1	NWD1 TBL1Y GEMIN5 LRBA	7.43e-03	278	52	4	PS00678
Domain	WD_REPEATS_2	NWD1 TBL1Y GEMIN5 LRBA	7.52e-03	279	52	4	PS50082
Domain	WD_REPEATS_REGION	NWD1 TBL1Y GEMIN5 LRBA	7.52e-03	279	52	4	PS50294
Domain	UBA	UBAC1 TNRC6C	7.59e-03	47	52	2	PS50030
Pathway	REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM	TCN1 LRP2 CUBN	2.48e-05	22	37	3	M27084
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFHR1 CFHR2	9.99e-05	6	37	2	M47880
Pathway	REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY	TCN1 LRP2	1.86e-04	8	37	2	M45025
Pathway	REACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES	TCN1 CUBN	2.98e-04	10	37	2	M45024
Pathway	WP_VITAMIN_B12_METABOLISM	TCN1 LRP2 CUBN	3.76e-04	54	37	3	M39337
Pathway	REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM	LRP2 CUBN	4.35e-04	12	37	2	M27088
Pathway	WP_VITAMIN_B12_DISORDERS	TCN1 CUBN	5.13e-04	13	37	2	M39778
Pubmed	Complement factor H and related proteins: an expanding family of complement-regulatory proteins?	CFHR1 CFHR2 C5	3.15e-08	5	52	3	8172644
Pubmed	Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.	LRP2 CUBN	2.19e-06	2	52	2	15616221
Pubmed	Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway.	CFHR1 CFHR2	2.19e-06	2	52	2	32636836
Pubmed	ACTN3 and MLCK genotype associations with exertional muscle damage.	MYLK ACTN3	2.19e-06	2	52	2	15817725
Pubmed	Role of megalin and cubilin in the metabolism of vitamin D(3).	LRP2 CUBN	2.19e-06	2	52	2	21595846
Pubmed	Molecular cloning of a human serum protein structurally related to complement factor H.	CFHR1 CFHR2	2.19e-06	2	52	2	1711047
Pubmed	Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.	LRP2 CUBN	2.19e-06	2	52	2	23978537
Pubmed	Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea.	LRP2 CUBN	2.19e-06	2	52	2	38008818
Pubmed	Differential distribution of cubilin and megalin expression in the mouse embryo.	LRP2 CUBN	2.19e-06	2	52	2	14983511
Pubmed	Megalin and cubilin in the human gallbladder epithelium.	LRP2 CUBN	2.19e-06	2	52	2	18791690
Pubmed	Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation.	CFHR1 C5	2.19e-06	2	52	2	19528535
Pubmed	Megalin and cubilin: multifunctional endocytic receptors.	LRP2 CUBN	2.19e-06	2	52	2	11994745
Pubmed	Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.	LRP2 CUBN	2.19e-06	2	52	2	10766831
Pubmed	Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.	CFHR1 CFHR2	2.19e-06	2	52	2	33651882
Pubmed	Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.	LRP2 CUBN	2.19e-06	2	52	2	11595644
Pubmed	Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.	LRP2 CUBN	2.19e-06	2	52	2	22437417
Pubmed	Association Analysis of the Cubilin (CUBN) and Megalin (LRP2) Genes with ESRD in African Americans.	LRP2 CUBN	2.19e-06	2	52	2	27197912
Pubmed	Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.	SYNE1 CSMD1	2.19e-06	2	52	2	24387768
Pubmed	Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.	LRP2 CUBN	2.19e-06	2	52	2	9334227
Pubmed	Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins.	TCN1 CUBN	2.19e-06	2	52	2	17487979
Pubmed	Differential expression of surface markers in mouse bone marrow mesenchymal stromal cell subpopulations with distinct lineage commitment.	PDGFRA CD200	2.19e-06	2	52	2	23236457
Pubmed	Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells.	LRP2 CUBN	2.19e-06	2	52	2	18448595
Pubmed	The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.	ZYG11A ZYG11B	2.19e-06	2	52	2	27810909
Pubmed	Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.	PRG3 PRG2	2.19e-06	2	52	2	17136616
Pubmed	Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes.	PRG3 PRG2	2.19e-06	2	52	2	11170744
Pubmed	Changes in allele frequencies of CSF3R and SETBP1 mutations and evidence of clonal evolution in a chronic neutrophilic leukemia patient treated with ruxolitinib.	CSF3R SETBP1	2.19e-06	2	52	2	28209656
Pubmed	Association study between genome-wide significant variants of vitamin B12 metabolism and gastric cancer in a han Chinese population.	TCN1 CUBN	2.19e-06	2	52	2	26959381
Pubmed	High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1.	LRP2 ABCB11	2.19e-06	2	52	2	10556425
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	LRP2 CUBN GALNT16	6.24e-06	24	52	3	31740596
Pubmed	Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.	LRP2 CUBN	6.57e-06	3	52	2	37126375
Pubmed	Identification of two new members of the CSMD gene family.	CSMD1 CSMD3	6.57e-06	3	52	2	12906867
Pubmed	Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules.	LRP2 CUBN	6.57e-06	3	52	2	15342463
Pubmed	Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).	LRP2 CUBN	6.57e-06	3	52	2	11717447
Pubmed	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.	CFHR1 CFHR2	6.57e-06	3	52	2	31273197
Pubmed	Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes.	LRP2 CUBN	6.57e-06	3	52	2	32803705
Pubmed	Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation.	LRP2 CUBN	6.57e-06	3	52	2	16787536
Pubmed	Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.	LRP2 CUBN	6.57e-06	3	52	2	17979745
Pubmed	Mouse model of proximal tubule endocytic dysfunction.	LRP2 CUBN	6.57e-06	3	52	2	21926402
Pubmed	Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.	LRP2 CUBN	6.57e-06	3	52	2	29186471
Pubmed	Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.	LRP2 CUBN	6.57e-06	3	52	2	18400109
Pubmed	Cubilin is essential for albumin reabsorption in the renal proximal tubule.	LRP2 CUBN	6.57e-06	3	52	2	20798259
Pubmed	Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats.	LRP2 CUBN	6.57e-06	3	52	2	28575050
Pubmed	A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.	LRP2 CUBN	6.57e-06	3	52	2	11278724
Pubmed	Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.	LRP2 CUBN	6.57e-06	3	52	2	12815097
Pubmed	Impaired endocytosis in proximal tubule from subchronic exposure to cadmium involves angiotensin II type 1 and cubilin receptors.	LRP2 CUBN	6.57e-06	3	52	2	24093454
Pubmed	Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia.	CSF3R SETBP1	6.57e-06	3	52	2	28209919
Pubmed	Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin.	LRP2 CUBN	6.57e-06	3	52	2	32200668
Pubmed	CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia.	CSF3R SETBP1	6.57e-06	3	52	2	25316523
Pubmed	Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.	LRP2 CUBN	6.57e-06	3	52	2	10811843
Pubmed	Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?	LRP2 CUBN	6.57e-06	3	52	2	37594671
Pubmed	Normal thymic selection of TCR transgenic CD4 T cells, but impaired survival in the periphery despite the presence of selecting MHC molecules.	CD4 C5	6.57e-06	3	52	2	9780168
Pubmed	C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.	CFHR1 CFHR2	6.57e-06	3	52	2	23728178
Pubmed	ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia.	CSF3R SETBP1	6.57e-06	3	52	2	25850813
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFHR1 CFHR2	1.31e-05	4	52	2	24333077
Pubmed	Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice.	LRP2 CUBN	1.31e-05	4	52	2	29032953
Pubmed	Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties.	CD4 C5	1.31e-05	4	52	2	11745379
Pubmed	The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study.	CD4 CD163	1.31e-05	4	52	2	38308298
Pubmed	HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.	PRG3 PRG2	1.31e-05	4	52	2	17308074
Pubmed	Factor H-related proteins determine complement-activating surfaces.	CFHR1 CFHR2	2.19e-05	5	52	2	25979655
Pubmed	Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.	CFHR1 CFHR2	2.19e-05	5	52	2	1689298
Pubmed	Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein.	LRP2 CUBN	2.19e-05	5	52	2	16263760
Pubmed	A radiation hybrid map of complement factor H and factor H-related genes.	CFHR1 CFHR2	2.19e-05	5	52	2	10380701
Pubmed	Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin.	TCN1 CUBN	2.19e-05	5	52	2	11788601
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNE1 GRB10 ZYG11B TNRC6C CSMD3 VPS13B	3.20e-05	407	52	6	12693553
Pubmed	Dimerization of complement factor H-related proteins modulates complement activation in vivo.	CFHR1 CFHR2	3.28e-05	6	52	2	23487775
Pubmed	Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.	MYLK PDGFRA	3.28e-05	6	52	2	32338642
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFHR1 CFHR2	3.28e-05	6	52	2	27196323
Pubmed	Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2.	PRG3 PRG2	3.28e-05	6	52	2	10770291
Pubmed	The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.	LRP2 CUBN	3.28e-05	6	52	2	19177150
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFHR1 CFHR2	3.28e-05	6	52	2	17438673
Pubmed	Vitamin D.	LRP2 CUBN	4.58e-05	7	52	2	15951480
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	UBR4 ZFYVE26	6.10e-05	8	52	2	37871017
Pubmed	Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.	TCN1 CUBN	6.10e-05	8	52	2	25147783
Pubmed	Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.	TCN1 CUBN	6.10e-05	8	52	2	19303062
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFHR1 CFHR2	7.84e-05	9	52	2	20059470
Pubmed	Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.	TCN1 CUBN	7.84e-05	9	52	2	19744961
Pubmed	Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.	CD4 C5	9.79e-05	10	52	2	10051620
Pubmed	CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.	CD4 CD163	9.79e-05	10	52	2	24942581
Pubmed	PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways.	PDGFRA GRB10	9.79e-05	10	52	2	24788519
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MYLK ENTPD2 EHMT1 LRP2 PTPRU GALNT16 DNASE2	1.03e-04	730	52	7	34857952
Pubmed	STING manifests self DNA-dependent inflammatory disease.	CD4 DNASE2	1.20e-04	11	52	2	23132945
Pubmed	Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection.	CD4 C5	1.20e-04	11	52	2	21704012
Pubmed	Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.	LRP2 CUBN	1.20e-04	11	52	2	18083160
Pubmed	Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.	TCN1 CUBN	1.43e-04	12	52	2	20852008
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	UBR4 ENTPD2 EHMT1 GRB10 GEMIN5 ZFYVE26 TNRC6C LRBA	2.20e-04	1105	52	8	35748872
Pubmed	Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.	GRB10 PTPRU	2.27e-04	15	52	2	19515692
Pubmed	Patterning and folding of intestinal villi by active mesenchymal dewetting.	MYLK PDGFRA	2.27e-04	15	52	2	38781967
Pubmed	Ontogeny of stromal organizer cells during lymph node development.	CD4 PDGFRA	2.60e-04	16	52	2	20237296
Pubmed	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.	PDGFRA SYNE1	2.60e-04	16	52	2	33495473
Pubmed	Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.	LRP2 CUBN	2.94e-04	17	52	2	29449453
Pubmed	A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo.	CD4 PDGFRA	3.30e-04	18	52	2	28494873
Pubmed	Gestational folate deficiency alters embryonic gene expression and cell function.	PDGFRA CUBN	3.30e-04	18	52	2	33302058
Pubmed	Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.	ABCB11 CSMD1	3.30e-04	18	52	2	24058526
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE1 SETBP1 EHMT1 TNRC6C	3.62e-04	225	52	4	12168954
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	PDGFRA CUBN	3.69e-04	19	52	2	31345929
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	UBR4 LRP2 TFDP3 GEMIN5 LRBA	4.00e-04	418	52	5	34709266
Pubmed	Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.	CD4 PDGFRA	4.52e-04	21	52	2	22072979
Pubmed	Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.	LRP2 CUBN	4.52e-04	21	52	2	27591083
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SYNE1 CEP126	4.97e-04	22	52	2	12812986
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	CFHR1 TCN1 C5 CD163	5.97e-04	257	52	4	16335952
Interaction	DEFB125 interactions	UBAC1 UBR4 LRP2 ZYG11B	1.85e-07	20	52	4	int:DEFB125
Interaction	CFHR2 interactions	CFHR1 CFHR2	1.96e-05	3	52	2	int:CFHR2
Interaction	HYAL1 interactions	PRG2 UBAC1 UBR4	5.65e-05	29	52	3	int:HYAL1
Interaction	AMBN interactions	UBAC1 LRP2	6.50e-05	5	52	2	int:AMBN
Cytoband	11q12	PRG3 PRG2	2.61e-04	21	52	2	11q12
Cytoband	14q24.1	ZFYVE26 GALNT16	7.31e-04	35	52	2	14q24.1
Cytoband	1p32.3	ZYG11A ZYG11B	2.21e-03	61	52	2	1p32.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFHR1 CFHR2	3.31e-03	75	52	2	chr1q31
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	UBAC1 ENTPD2 EHMT1	6.01e-03	325	52	3	chr9q34
Cytoband	9q34.3	UBAC1 EHMT1	6.49e-03	106	52	2	9q34.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	PRG3 TCN1 PRG2	7.08e-03	345	52	3	chr11q12
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR1 CFHR2 CSMD1 CSMD3	6.72e-06	57	39	4	1179
GeneFamily	ZYG11 cell cycle regulator family	ZYG11A ZYG11B	1.36e-05	3	39	2	6
GeneFamily	Complement system\|Sushi domain containing	CFHR1 CFHR2 C5	6.31e-05	36	39	3	492
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD4 CSF3R PDGFRA CD163 CD200	1.50e-03	394	39	5	471
GeneFamily	WD repeat domain containing	NWD1 TBL1Y GEMIN5 LRBA	2.38e-03	262	39	4	362
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PRG3 PRG2	3.53e-03	41	39	2	1298
GeneFamily	Fibronectin type III domain containing	MYLK CSF3R PTPRU	4.92e-03	160	39	3	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYLK PDGFRA CEACAM20	5.01e-03	161	39	3	593
Coexpression	BENPORATH_ES_WITH_H3K27ME3	PDGFRA SYNE1 ENTPD2 LRP2 GRB10 LRBA PTPRU CSMD1 CSMD3 GALNT16 RYR3	9.54e-06	1115	52	11	M10371
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SETBP1 LRP2 GRB10 LRBA CUBN VPS13B	9.66e-08	192	52	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK PDGFRA ENTPD2 LRP2 CSMD1 RYR3	1.09e-07	196	52	6	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK PDGFRA ENTPD2 LRP2 CSMD1 RYR3	1.09e-07	196	52	6	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NWD1 LRP2 CUBN CSMD1 CSMD3	1.50e-06	167	52	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	droplet-Lung-nan-21m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRG3 TCN1 PRG2 GALNT16 RYR3	1.68e-06	171	52	5	159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCell	droplet-Lung-nan-21m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRG3 TCN1 PRG2 GALNT16 RYR3	2.11e-06	179	52	5	d78eacf47847a50888dd16c35bed9b7afc80010f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 LRP2 CSMD1 CSMD3 RYR3	2.41e-06	184	52	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 LRP2 CSMD1 CSMD3 RYR3	2.41e-06	184	52	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 LRP2 CSMD1 CSMD3 RYR3	2.41e-06	184	52	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 GALNT16 SAMD4A	3.45e-06	198	52	5	0993d6895c0e4f360998ce35abea4ec3dd13e048
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD4 CSF3R IQGAP2 UBR4 CD163	3.53e-06	199	52	5	667b8b47a5b388506e3177b46747267fad8024f6
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR1 CFHR2 TCN1 ABCB11	2.10e-05	139	52	4	82bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR1 CFHR2 TCN1 ABCB11	2.10e-05	139	52	4	fc9ac09c2106e88104a52575832d71d17765eec8
ToppCell	facs-Liver-Hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR1 CFHR2 TCN1 ABCB11	2.10e-05	139	52	4	fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR1 CFHR2 TCN1 ABCB11	2.10e-05	139	52	4	4ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR1 CFHR2 TCN1 ABCB11	2.62e-05	147	52	4	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRG3 CSF3R CSMD1 CSMD3	2.76e-05	149	52	4	c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRG3 CSF3R CSMD1 CSMD3	2.76e-05	149	52	4	a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR1 CFHR2 TCN1 ABCB11	2.91e-05	151	52	4	cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	UBR4 GRB10 RYR3 SAMD4A	3.31e-05	156	52	4	895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CSF3R TCN1 SYNE1 CUBN	3.65e-05	160	52	4	bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CSF3R TCN1 SYNE1 CUBN	3.65e-05	160	52	4	76f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs\|GI_large-bowel / Manually curated celltypes from each tissue	CD4 IQGAP2 GALNT16 CD200	3.83e-05	162	52	4	9a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	TMEM232 TBL1Y CEP126 FAM217A	3.93e-05	163	52	4	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	facs-Marrow-KLS-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRG3 PRG2 SETBP1 RYR3	4.02e-05	164	52	4	d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 ABCB11 DDX60L CUBN	4.52e-05	169	52	4	d0c64ca31053dfc283a07d5ad1117ca7dc1777a7
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CUBN CSMD3 RYR3	4.52e-05	169	52	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 ABCB11 DDX60L CUBN	4.52e-05	169	52	4	d79abfbeffd082a4fbffbc1051ffc474374874fa
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	CD4 IQGAP2 DDX60L CD163	4.62e-05	170	52	4	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	MYLK SYNE1 LRP2 CD200	4.84e-05	172	52	4	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA IQGAP2 SETBP1 ENTPD2	4.95e-05	173	52	4	c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CUBN CSMD3 RYR3	4.95e-05	173	52	4	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CUBN CSMD3 RYR3	4.95e-05	173	52	4	649b08a409095592cccf31883be69c754411280d
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CUBN CSMD3 RYR3	5.06e-05	174	52	4	f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	CFHR1 CFHR2 ABCB11 C5	5.06e-05	174	52	4	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IQGAP2 LRP2 CUBN CSMD1	5.29e-05	176	52	4	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBL1Y PTPRU GALNT16 RYR3	5.41e-05	177	52	4	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	KIFBP SYNE1 TNRC6C CSMD3	5.41e-05	177	52	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD4 DDX60L DNASE2 CD163	5.53e-05	178	52	4	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRG3 TCN1 GALNT16 RYR3	5.65e-05	179	52	4	4f20540bfbcefe0e83812be7ea542e8bb3bf19bc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBL1Y PTPRU GALNT16 RYR3	5.65e-05	179	52	4	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFHR1 CD4 DNASE2 CD163	5.65e-05	179	52	4	b07ebfd4157ae7436f275add78f2ac9ffc55f417
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	PRG3 TCN1 PRG2 RYR3	5.77e-05	180	52	4	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	3'_v3-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	PRG3 TCN1 PRG2 RYR3	5.90e-05	181	52	4	30ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	NWD1 LRP2 CUBN CSMD1	5.90e-05	181	52	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A LRP2 CUBN CSMD1	6.03e-05	182	52	4	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A LRP2 CUBN CSMD1	6.03e-05	182	52	4	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZYG11A LRP2 CUBN CSMD1	6.03e-05	182	52	4	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CD4 CSF3R IQGAP2 CD163	6.16e-05	183	52	4	a97f052950429245c3231464271e1ba539863bba
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IQGAP2 LRP2 CUBN CSMD1	6.16e-05	183	52	4	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA ENTPD2 ACTN3 CSMD1	6.56e-05	186	52	4	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK TCN1 PDGFRA GALNT16	6.98e-05	189	52	4	1821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK TCN1 PDGFRA GALNT16	6.98e-05	189	52	4	1e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK TCN1 PDGFRA GALNT16	6.98e-05	189	52	4	1dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD4 CSF3R DDX60L CD163	7.12e-05	190	52	4	57800d807785b9d539b47945a0a74631f5e88a06
ToppCell	(4)_Endothelial_cells-(40)_EC-arterial\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	TRIM16 PRG2 SYNE1 CD200	7.12e-05	190	52	4	ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD4 CSF3R ACTN3 CD163	7.27e-05	191	52	4	51f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF3R TCN1 SYNE1 CSMD3	7.27e-05	191	52	4	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD4 CSF3R ACTN3 CD163	7.27e-05	191	52	4	8fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD4 CSF3R DDX60L CD163	7.27e-05	191	52	4	1c7d31684654ca6a046d8cc816af1fdc42369c57
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD4 CSF3R DDX60L CD163	7.27e-05	191	52	4	d60d81d2045c6e624bbc8b17e13a32f7921d969f
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR2 PDGFRA ENTPD2 CSMD1	7.41e-05	192	52	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD4 CSF3R IQGAP2 CD163	7.41e-05	192	52	4	86d792682ba51696f503c79625dd20f87bcf651f
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA ENTPD2 CSMD1 GALNT16	7.41e-05	192	52	4	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR2 PDGFRA ENTPD2 CSMD1	7.41e-05	192	52	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	CD4 CSF3R IQGAP2 CD163	7.41e-05	192	52	4	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD4 CSF3R IQGAP2 CD163	7.41e-05	192	52	4	d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFHR2 PDGFRA ENTPD2 CSMD1	7.41e-05	192	52	4	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRA ENTPD2 CSMD1 GALNT16	7.41e-05	192	52	4	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	CD4 CSF3R IQGAP2 CD163	7.56e-05	193	52	4	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	NWD1 TMEM232 SYNE1 CEP126	7.56e-05	193	52	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM232 LRP2 LRBA CUBN	7.56e-05	193	52	4	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	COVID-19-Heart-Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	CD4 CSF3R IQGAP2 CD163	7.72e-05	194	52	4	f09675cd472200363c458952f00d2e41990800ee
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	NWD1 TMEM232 SYNE1 CEP126	7.72e-05	194	52	4	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD4 CSF3R IQGAP2 CD163	7.72e-05	194	52	4	0866ab6792cee274a71991d5c37a37f574ff446e
ToppCell	(2)_Mono_macro\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	CD4 CSF3R IQGAP2 CD163	7.72e-05	194	52	4	7c05525614ee8cdfcbf22cce9146a8e73af7d14e
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	7.87e-05	195	52	4	2514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF3R CSMD1 GALNT16 RYR3	7.87e-05	195	52	4	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF3R CSMD1 GALNT16 RYR3	7.87e-05	195	52	4	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	E17.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYLK PDGFRA GRB10 SAMD4A	7.87e-05	195	52	4	1daddd801bd4596fffbdb822fc326d5127c96004
ToppCell	E17.5-Mesenchymal-myocytic_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYLK PDGFRA GRB10 SAMD4A	7.87e-05	195	52	4	01a750d660993017af00736215cbcff2de5909c1
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NWD1 TMEM232 SYNE1 CEP126	7.87e-05	195	52	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	Fibroblast-B_(Myofibroblast)\|World / shred on cell class and cell subclass (v4)	MYLK PDGFRA GRB10 SAMD4A	7.87e-05	195	52	4	a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	7.87e-05	195	52	4	2414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 SETBP1 CSMD1 CSMD3	8.03e-05	196	52	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.03e-05	196	52	4	e4d04e1f82779e8afd4e32bbe38d1d3f6f64ab50
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.03e-05	196	52	4	f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDGFRA GRB10 CSMD1 SAMD4A	8.03e-05	196	52	4	9d7b631f24a19a7dc7a28f28525d4019fc8fcf8a
ToppCell	P07-Mesenchymal-myocytic_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYLK PDGFRA GRB10 GALNT16	8.19e-05	197	52	4	378299fe2ec6ed2fc858febb78ff1ac0898e457d
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDGFRA GRB10 CSMD1 SAMD4A	8.19e-05	197	52	4	7d97c2d51a543c02d679e9257b22d0581e73a11d
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.19e-05	197	52	4	26475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCell	P03-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYLK PDGFRA CSMD1 SAMD4A	8.19e-05	197	52	4	2cec938caf6ffd031cea37277071487e59b2c71c
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDGFRA GRB10 CSMD1 SAMD4A	8.19e-05	197	52	4	671d6b5effbac2dd71d18f48d23c523738db1828
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.19e-05	197	52	4	9d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.19e-05	197	52	4	090a251194da3e2806989d9a522588f83f52da7f
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.19e-05	197	52	4	43b5f8e917506c1717f9311584901b506ffd2c79
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.19e-05	197	52	4	155e63b33302a87393ace699b2f6d73abe9c5763
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.35e-05	198	52	4	63f7d25201613bd3404c28fb936954190bca91d3
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK PDGFRA GRB10 SAMD4A	8.35e-05	198	52	4	a73534b6ca202c277a70a52281d5b97a3e6cb8ef
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 SETBP1 CSMD1 CSMD3	8.35e-05	198	52	4	c01091ef18e096d792ea2a7a715764a5b215355f
Computational	Fetal liver genes - metabolism and xenobiotics.	TRIM16 CFHR1 CSF3R PDGFRA IQGAP2 PRG2 C5 CD163	5.12e-05	453	33	8	MODULE_24
Computational	Genes in the cancer module 55.	TRIM16 CFHR1 MYLK CSF3R PDGFRA IQGAP2 PRG2 ENTPD2 C5 CD163	1.31e-04	832	33	10	MODULE_55
Computational	Heart, liver, kidney and pancreas metabolic and xenobiotic response genes.	TRIM16 CFHR1 MYLK CSF3R PDGFRA IQGAP2 PRG2 ENTPD2 C5 CD163	1.35e-04	835	33	10	MODULE_88
Computational	Immune response.	CFHR1 CD4 MYLK CSF3R PDGFRA PRG2 C5	1.68e-04	398	33	7	MODULE_75
Computational	RTK signaling.	MYLK CSF3R PDGFRA	3.66e-04	46	33	3	MODULE_259
Computational	Genes in the cancer module 27.	TMPRSS15 CD4 CSF3R PDGFRA LRP2 CD163	6.47e-04	355	33	6	MODULE_27
Computational	Genes in the cancer module 199.	MYLK CSF3R PDGFRA	6.89e-04	57	33	3	MODULE_199
Computational	Genes in the cancer module 11.	TRIM16 MYLK PDGFRA SYNE1 SETBP1 RYR3 CD200	1.06e-03	540	33	7	MODULE_11
Computational	Genes in the cancer module 46.	CFHR1 CD4 CSF3R PDGFRA PRG2 C5	1.12e-03	394	33	6	MODULE_46
Computational	Genes in the cancer module 58.	CFHR1 C5	1.85e-03	21	33	2	MODULE_58
Computational	Complement.	CFHR1 C5	2.22e-03	23	33	2	MODULE_130
Computational	Genes in the cancer module 138.	MYLK CSF3R PDGFRA	2.34e-03	87	33	3	MODULE_138
Computational	Placenta genes.	TRIM16 MYLK CSF3R PDGFRA PRG2 PTPRU	2.54e-03	463	33	6	MODULE_38
Computational	Genes in the cancer module 200.	CD4 PDGFRA	3.06e-03	27	33	2	MODULE_200
Disease	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	CSF3R SETBP1	9.13e-06	3	52	2	C1292772
Disease	amino acid measurement	CD4 SYNE1 LRP2 GRB10 C5 LRBA CSMD1 RYR3	2.30e-05	678	52	8	EFO_0005134
Disease	Complement deficiency disease	CFHR1 CFHR2 C5	2.71e-05	33	52	3	C0272242
Disease	Colorectal Carcinoma	PRG2 SYNE1 SETBP1 LRP2 ABCB11 PTPRU CUBN CSMD3	2.95e-05	702	52	8	C0009402
Disease	Anemia, Megaloblastic	TCN1 CUBN	3.04e-05	5	52	2	C0002888
Disease	Drug habituation	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0013170
Disease	Substance-Related Disorders	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0236969
Disease	Drug abuse	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0013146
Disease	Drug Use Disorders	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0013222
Disease	Drug Dependence	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C1510472
Disease	Substance Dependence	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0038580
Disease	Substance Use Disorders	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C0029231
Disease	Prescription Drug Abuse	SYNE1 CSMD1 CSMD3 SAMD4A	5.13e-05	115	52	4	C4316881
Disease	Substance abuse problem	SYNE1 CSMD1 CSMD3 SAMD4A	5.31e-05	116	52	4	C0740858
Disease	neutropenia (implicated_via_orthology)	CSF3R C5	6.36e-05	7	52	2	DOID:1227 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	SYNE1 SETBP1 UBR4 EHMT1 ZFYVE26 LRBA CUBN GALNT16 VPS13B	9.75e-05	1074	52	9	C0006142
Disease	C3 glomerulopathy	CFHR1 CFHR2	1.09e-04	9	52	2	C4087273
Disease	COVID-19, mortality	TMEM232 PRG2 LRP2 GALNT16	2.32e-04	170	52	4	EFO_0004352, MONDO_0100096
Disease	membranous glomerulonephritis (biomarker_via_orthology)	LRP2 PTPRU	2.73e-04	14	52	2	DOID:10976 (biomarker_via_orthology)
Disease	Proteinuria	LRP2 CUBN	3.15e-04	15	52	2	HP_0000093
Disease	response to paliperidone, schizophrenia symptom severity measurement	IQGAP2 CSMD1 CSMD3 SAMD4A	5.74e-04	216	52	4	EFO_0007925, EFO_0007927
Disease	nephrosis (biomarker_via_orthology)	LRP2 PTPRU	6.88e-04	22	52	2	DOID:2527 (biomarker_via_orthology)
Disease	aspartate aminotransferase measurement	IQGAP2 ABCB11 LRBA CUBN CSMD1 CD163 SAMD4A	9.96e-04	904	52	7	EFO_0004736
Disease	Myeloid Leukemia, Chronic	CSF3R SETBP1	1.20e-03	29	52	2	C0023473
Disease	pappalysin‐1 measurement	PRG3 PRG2	1.20e-03	29	52	2	EFO_0010618
Disease	complement factor H-related protein 2 measurement	CFHR1 CFHR2	1.20e-03	29	52	2	EFO_0600055
Disease	Age related macular degeneration	CFHR1 CFHR2	1.28e-03	30	52	2	C0242383
Disease	vitamin B12 measurement	TCN1 CUBN	1.46e-03	32	52	2	EFO_0004620
Disease	HOMA-IR	PTPRU CSMD1	1.55e-03	33	52	2	EFO_0004501
Disease	IGA Glomerulonephritis	CFHR1 CD163	1.65e-03	34	52	2	C0017661
Disease	coronary aneurysm	SETBP1 CSMD1	1.75e-03	35	52	2	EFO_1000881

Protein segments in the cluster

Peptide	Gene	Start	Entry
GERVITCQQNNQWSG	CSMD1	561	Q96PZ7
TCQQNNQWSGNKPSC	CSMD1	566	Q96PZ7
SIVCQENNQWSANIP	CSMD3	701	Q7Z407
CQTVNQSVNVQWFLS	CEACAM20	276	Q6UY09
ACVNNTIVWTNSSLN	ABCB11	106	O95342
SKCQADAQAQQWQLL	GALNT16	541	Q8N428
LVGQLCQQAQSWFQL	NWD1	826	Q149M9
CNNETSWTILANNVS	PDGFRA	456	P16234
NAQGQLSCSWTLQVE	MYLK	491	Q15746
NWTTQISNDVCQLLG	TMPRSS15	706	P98073
LSNLNVFGCWNLNLN	DDX60L	341	Q5H9U9
AAAVNVCNQTWAQLQ	ENTPD2	371	Q9Y5L3
QNNENNISCVERGWS	CFHR2	121	P36980
LLCSQEWQNSIQKNA	LRBA	1856	P50851
QWQCLGHNICVNLSV	LRP2	1316	P98164
LNQLNQSNSAWPCLQ	PTPRU	1276	Q92729
CSLQNAQEALIVTWQ	CD200	51	P41217
QCSVSALNQGQVWIG	PRG2	146	P13727
CTSTVNQAQVWIGGN	PRG3	151	Q9Y2Y8
NLNCEWTLSNPNQGN	CUBN	2596	O60494
TVWALQLTSQDCTQN	CUBN	3321	O60494
NCSDIWQVLNVNQIA	DNASE2	266	O00115
NQWNQESSSPLSNAC	CEP126	851	Q9P2H0
LQIKQNCSWNITLTN	POLQ	1116	O75417
NQNSICNSLLWLVEN	C5	1096	P01031
LQDSGTWTCTVLQNQ	CD4	176	P01730
CCLNWGNSLQILDQV	CSF3R	101	Q99062
MVTWCQQSNGSQTQL	GRB10	266	Q13322
QNNENNISCVERGWS	CFHR1	121	Q03591
STQNSKQGIFQLWNC	FAM217A	76	Q8IXS0
QATNTWLFLSSCNGN	CD163	431	Q86VB7
LQCASLNSQVWSALQ	EHMT1	976	Q9H9B1
SLCIQAQNNLGILWS	KIFBP	136	Q96EK5
SCSLFNLQNWLNTSN	LRRC19	181	Q9H756
CWGASNSNAGINLNL	TNRC6C	86	Q9HCJ0
ESQLNQLGECWLSNT	SYNE1	6766	Q8NF91
QGQDNLSWNEIQNCI	IQGAP2	426	Q13576
QAICDQWDNLGTLTQ	ACTN3	491	Q08043
SGLGSNKWIQQNLQC	ZYG11B	126	Q9C0D3
NRNNCAQFSNNLDWL	RYR3	531	Q15413
AWSCVQNNSPQLNNV	TMEM232	271	C9JQI7
CAQELLLANNWVGAQ	GEMIN5	1091	Q8TEQ6
NDWNCQQTLNTVLTE	TCN1	261	P20061
LWNLGNTCCVNAISQ	USP50	46	Q70EL3
WNLNENSNGGSTQLV	TBL1Y	206	Q9BQ87
WIGLTTNSAQNCQNL	TFDP3	186	Q5H9I0
QWNNGSVCQEIQFLA	VPS13B	2536	Q7Z7G8
RNSCISGNNFSWSLQ	TRIM16	456	O95361
LRVNNNQQNAACEWL	UBAC1	311	Q9BSL1
NLPSSVQTVCESWNN	UBR4	1221	Q5T4S7
GNTWSQLSNNNKDLL	SETBP1	271	Q9Y6X0
SGLCSNRWIQQNLQC	ZYG11A	146	Q6WRX3
LQQGQSLAVNLCGWA	ZFYVE26	1381	Q68DK2
QNSRDSGICINASNW	SAMD4A	191	Q9UPU9