Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	actin filament-based process	ESPN ANTXR1 DAAM2 RASA1 KCNC3 UTY WASF2 IQSEC2	4.51e-05	912	31	8	GO:0030029
Domain	SMR-like	SMR3A SMR3B	7.99e-06	3	31	2	IPR026288
Domain	PROL5-SMR	SMR3A SMR3B	7.99e-06	3	31	2	PF15621
Domain	WH2	ESPN WASF2	2.40e-04	14	31	2	SM00246
Domain	WH2	ESPN WASF2	3.15e-04	16	31	2	PF02205
Domain	WH2_dom	ESPN WASF2	5.49e-04	21	31	2	IPR003124
Domain	WH2	ESPN WASF2	7.19e-04	24	31	2	PS51082
Domain	IQ_motif_EF-hand-BS	MYO16 IQSEC2	9.75e-03	90	31	2	IPR000048
Domain	IQ	MYO16 IQSEC2	1.04e-02	93	31	2	PS50096
Domain	PH	RASA1 SH3BP2 IQSEC2	1.08e-02	278	31	3	SM00233
Domain	PH_DOMAIN	RASA1 SH3BP2 IQSEC2	1.09e-02	279	31	3	PS50003
Domain	PH_domain	RASA1 SH3BP2 IQSEC2	1.10e-02	280	31	3	IPR001849
Domain	SH2	RASA1 SH3BP2	1.22e-02	101	31	2	PF00017
Domain	SH2	RASA1 SH3BP2	1.43e-02	110	31	2	SM00252
Domain	SH2	RASA1 SH3BP2	1.45e-02	111	31	2	PS50001
Domain	SH2	RASA1 SH3BP2	1.48e-02	112	31	2	IPR000980
Domain	-	RASA1 SH3BP2	1.48e-02	112	31	2	3.30.505.10
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	TOMM40 RBBP6 MYO16 WASF2	7.91e-06	143	31	4	32560809
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1A PDCD7 RBBP6 CCNK	7.15e-05	251	31	4	31076518
Pubmed	A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.	SETD1A CCNK	1.17e-04	18	31	2	29474905
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	RASA1 SH3BP2	2.10e-04	24	31	2	20624904
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	CCNK WASF2 YLPM1	3.49e-04	154	31	3	16055720
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	PDCD7 RBBP6 CCNK WASF2 YLPM1	3.61e-04	701	31	5	30196744
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ESPN PCED1A SETD1A DAAM2 ZNF341 ALG13	7.01e-04	1242	31	6	30973865
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	SETD1A UTY	8.81e-04	49	31	2	34368113
Interaction	PRMT2 interactions	ESPN ANTXR1 SETD1A DMRTB1 ZNF341 IQSEC2 YLPM1	7.29e-11	91	31	7	int:PRMT2
Interaction	SH3RF1 interactions	VPS37C DMRTB1 ONECUT3 SH3BP2	2.20e-05	108	31	4	int:SH3RF1
Cytoband	4q13.3	SMR3A SMR3B	3.74e-04	42	31	2	4q13.3
GeneFamily	SH2 domain containing	RASA1 SH3BP2	5.50e-03	101	20	2	741
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MYO16 YLPM1	1.68e-02	181	20	2	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASA1 SH3BP2	2.15e-02	206	20	2	682
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SP5 DAAM2 KCNC3	8.15e-06	186	31	4	e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCell	droplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SP5 DAAM2 KCNC3	8.15e-06	186	31	4	4c0b59d845b79323e7a3287e7c4d249f5f322556
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	SMR3A SETD1A UTY BTBD7	1.34e-04	194	31	4	3422_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	VPS37C BTBD7 SH3BP2 IQSEC2	1.37e-04	195	31	4	7101_UP
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	SETD1A BTBD7 SH3BP2 YLPM1	1.40e-04	196	31	4	1629_DN
Drug	Benzathine benzylpenicillin [5928-84-7]; Up 200; 4.2uM; HL60; HT_HG-U133A	UTY SH3BP2 YLPM1 ALG13	1.40e-04	196	31	4	2939_UP
Drug	radicicol; Down 200; 0.1uM; MCF7; HG-U133A	DAAM2 KCNC3 UTY SH3BP2	1.40e-04	196	31	4	325_DN
Drug	Ofloxacin [82419-36-1]; Down 200; 11uM; MCF7; HT_HG-U133A	ANTXR1 CCNK SH3BP2 IQSEC2	1.42e-04	197	31	4	2302_DN
Drug	N6-methyladenosine [1867-73-8]; Up 200; 14.2uM; MCF7; HT_HG-U133A	VPS37C UTY BTBD7 YLPM1	1.42e-04	197	31	4	5332_UP
Drug	Carbachol [51-83-2]; Down 200; 21.8uM; HL60; HT_HG-U133A	SMR3A SETD1A BTBD7 SH3BP2	1.42e-04	197	31	4	3042_DN
Drug	copper(II) sulfate pentahydrate; Up 200; 100uM; MCF7; HG-U133A	SETD1A UTY ZFR2 SH3BP2	1.42e-04	197	31	4	438_UP
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; PC3; HT_HG-U133A	UTY BTBD7 SH3BP2 IQSEC2	1.42e-04	197	31	4	4474_DN
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A	UTY BTBD7 SH3BP2 IQSEC2	1.42e-04	197	31	4	5939_UP
Drug	Convolamine hydrochloride [500-56-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SETD1A UTY BTBD7 SH3BP2	1.45e-04	198	31	4	2771_DN
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A	SMR3A UTY BTBD7 IQSEC2	1.45e-04	198	31	4	4759_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; HL60; HT_HG-U133A	SMR3A SETD1A BTBD7 SH3BP2	1.45e-04	198	31	4	2352_DN
Drug	Pipenzolate bromide [125-51-9]; Down 200; 9.2uM; PC3; HT_HG-U133A	SMR3A UTY BTBD7 IQSEC2	1.48e-04	199	31	4	4484_DN
Disease	Epilepsy	SETD1A IQSEC2 ALG13	1.50e-04	109	28	3	C0014544
Disease	Mental Retardation, X-Linked 1	IQSEC2 ALG13	4.23e-04	32	28	2	C2931498
Disease	schizophrenia (implicated_via_orthology)	SETD1A NLGN2	1.90e-03	68	28	2	DOID:5419 (implicated_via_orthology)
Disease	Epilepsy, Cryptogenic	IQSEC2 ALG13	2.75e-03	82	28	2	C0086237
Disease	Awakening Epilepsy	IQSEC2 ALG13	2.75e-03	82	28	2	C0751111
Disease	Aura	IQSEC2 ALG13	2.75e-03	82	28	2	C0236018
Disease	beta-amyloid 1-42 measurement	DMRTB1 TOMM40	3.09e-03	87	28	2	EFO_0004670
Disease	Neurodevelopmental Disorders	IQSEC2 ALG13	3.52e-03	93	28	2	C1535926
Disease	chronotype measurement	RASA1 RBBP6 MYO16 SH3BP2	9.17e-03	882	28	4	EFO_0008328
Disease	Schizophrenia	SETD1A DAAM2 NLGN2 MYO16	9.21e-03	883	28	4	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPPPPLPPPPYSCDP	ALG13	956	Q9NP73
PPPAPIYTPPPPAPH	ANTXR1	506	Q9H6X2
IYTPPPPAPHCPPPP	ANTXR1	511	Q9H6X2
PPAYPPPPVPTPRKP	SH3BP2	201	P78314
PPAIPPPTPGYPPPP	CCNK	496	O75909
PPTPGYPPPPPTYNP	CCNK	501	O75909
GGGFPPLPPPPYLPP	RASA1	131	P20936
PPPPPPLPFACCPPP	DAAM2	541	Q86T65
PPPPPGPPPAPYRPC	MYO16	1576	Q9Y6X6
IPPHPSYPPLPPPSP	IQSEC2	1431	Q5JU85
GKPTPPPPPPSFPPP	ESPN	426	B1AK53
PPPPGTQLPPPPPGY	ESPN	441	B1AK53
YPVPPPPLPPPPPQC	PDCD7	81	Q8N8D1
PMPFPYPLPQPSPPP	PCED1A	321	Q9H1Q7
FVPVPPPPLYPPPPH	RBBP6	556	Q7Z6E9
PPPLYPPPPHTLPLP	RBBP6	561	Q7Z6E9
SYYLPPPPPPLPPLP	DMRTB1	261	Q96MA1
PPPYPGPGPTAPYPP	CYSTM1	6	Q9H1C7
PPLPPPPPPYHPPAT	BTBD7	756	Q9P203
YGALPPPPGPPPAPY	FIGNL2	216	A6NMB9
PPPPSLHPFGPFPPP	NLGN2	801	Q8NFZ4
PPPPPPPPPLAAYGP	ONECUT3	216	O60422
PPPRPPTSPYPPLPK	UTY	866	O14607
PPGYSNLLPPPPPPP	SP5	156	Q6BEB4
PPPYGPGRIPPPPPA	SMR3B	51	P02814
PPPPAPYGPGIFPPP	SMR3B	61	P02814
PPPPPPPPPPPYLAS	SETD1A	606	O15047
PRPDGPPPPEYPPPP	SETD1A	636	O15047
VPSYLTQPPPPPPPP	ZNF341	171	Q9BYN7
PQPPPTFPPGPYLLP	ZNF865	481	P0CJ78
PFYPPAQPPPPPGPP	ZFR2	216	Q9UPR6
PRGPYPPGPLAPPPP	SMR3A	26	Q99954
PPPHPPPYGPGRFPP	SMR3A	51	Q99954
PPYGPGRFPPPLSPP	SMR3A	56	Q99954
SSHYPPPPVPPPPPV	YLPM1	11	P49750
PPPPPPAADYPTLPP	WASF2	366	Q9Y6W5
PPPPPSPPGFTLPPL	TOMM40	26	O96008
PGPAPPYGFPPPPGP	VPS37C	336	A5D8V6
SPNYCKPDPPPPPPP	KCNC3	571	Q14003
PPSPPPSYHPPPPPT	KIAA1522	671	Q9P206