Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentphagocytic vesicle membrane

ATP6V0A1 MPEG1 RAB34 SEC61A1 DNM2

1.12e-04831195GO:0030670
MousePhenodecreased eosinophil cell number

ZNF208 FCER1A TBK1 GNAI2 ZNF91 NOS2

1.74e-0584916MP:0005012
DomainSecY_su_dom

SEC61A2 SEC61A1

3.56e-0521122IPR023201
DomainGln-Leu-Gln_QLQ

SMARCA2 SMARCA4

3.56e-0521122IPR014978
DomainSnAC

SMARCA2 SMARCA4

3.56e-0521122PF14619
DomainQLQ

SMARCA2 SMARCA4

3.56e-0521122SM00951
DomainSECY_1

SEC61A2 SEC61A1

3.56e-0521122PS00755
DomainSECY_2

SEC61A2 SEC61A1

3.56e-0521122PS00756
Domain-

SEC61A2 SEC61A1

3.56e-05211221.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A2 SEC61A1

3.56e-0521122IPR019561
DomainSecY_CS

SEC61A2 SEC61A1

3.56e-0521122IPR030659
DomainQLQ

SMARCA2 SMARCA4

3.56e-0521122PS51666
DomainSnAC

SMARCA2 SMARCA4

3.56e-0521122SM01314
DomainPlug_translocon

SEC61A2 SEC61A1

3.56e-0521122PF10559
DomainSnAC

SMARCA2 SMARCA4

3.56e-0521122IPR029295
DomainSecY

SEC61A2 SEC61A1

3.56e-0521122PF00344
DomainQLQ

SMARCA2 SMARCA4

3.56e-0521122PF08880
DomainSecY/SEC61-alpha

SEC61A2 SEC61A1

3.56e-0521122IPR002208
DomainGPS

PKD1L1 ADGRB3 PKDREJ CELSR3

6.95e-05371124IPR000203
DomainVWF_type-D

VWF MUC19 VWDE

1.11e-04161123IPR001846
DomainVWFD

VWF MUC19 VWDE

1.11e-04161123PS51233
DomainVWD

VWF MUC19 VWDE

1.11e-04161123SM00216
DomainVWD

VWF MUC19 VWDE

1.11e-04161123PF00094
DomainHSA

SMARCA2 SMARCA4

2.12e-0441122SM00573
DomainHSA

SMARCA2 SMARCA4

2.12e-0441122PS51204
DomainREJ

PKD1L1 PKDREJ

2.12e-0441122PS51111
DomainHSA_dom

SMARCA2 SMARCA4

2.12e-0441122IPR014012
DomainREJ_dom

PKD1L1 PKDREJ

2.12e-0441122IPR014010
DomainHSA

SMARCA2 SMARCA4

2.12e-0441122PF07529
DomainHormR

VIPR2 ADGRB3 CELSR3

4.39e-04251123SM00008
DomainBRK

SMARCA2 SMARCA4

5.26e-0461122SM00592
DomainBRK_domain

SMARCA2 SMARCA4

5.26e-0461122IPR006576
DomainPKD/REJ-like

PKD1L1 PKDREJ

5.26e-0461122IPR002859
DomainREJ

PKD1L1 PKDREJ

5.26e-0461122PF02010
DomainBRK

SMARCA2 SMARCA4

5.26e-0461122PF07533
DomainHRM

VIPR2 ADGRB3 CELSR3

6.17e-04281123PF02793
DomainP2X_receptor

P2RX1 P2RX4

7.34e-0471122PF00864
DomainP2X_purnocptor

P2RX1 P2RX4

7.34e-0471122IPR001429
Domain-

P2RX1 P2RX4

7.34e-04711222.60.490.10
DomainP2X_RECEPTOR

P2RX1 P2RX4

7.34e-0471122PS01212
DomainP2X_extracellular_dom

P2RX1 P2RX4

7.34e-0471122IPR027309
DomainSNF2_N

SMARCA1 SMARCA2 SMARCA4

9.17e-04321123IPR000330
DomainSNF2_N

SMARCA1 SMARCA2 SMARCA4

9.17e-04321123PF00176
DomainWD40

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

9.56e-042591127PF00400
DomainGPS

ADGRB3 PKDREJ CELSR3

1.10e-03341123SM00303
DomainGPCR_2_secretin-like_CS

VIPR2 ADGRB3 CELSR3

1.10e-03341123IPR017983
DomainWD40

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

1.17e-032681127SM00320
DomainWD40_repeat

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

1.27e-032721127IPR001680
DomainGPS

PKD1L1 ADGRB3 CELSR3

1.30e-03361123PS50221
DomainWD_REPEATS_1

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

1.44e-032781127PS00678
DomainWD_REPEATS_2

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

1.47e-032791127PS50082
DomainWD_REPEATS_REGION

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

1.47e-032791127PS50294
DomainGPCR_2_extracellular_dom

VIPR2 ADGRB3 CELSR3

1.76e-03401123IPR001879
DomainG_PROTEIN_RECEP_F2_1

VIPR2 ADGRB3 CELSR3

1.76e-03401123PS00649
DomainG_PROTEIN_RECEP_F2_3

VIPR2 ADGRB3 CELSR3

1.76e-03401123PS50227
DomainGAIN_dom_N

ADGRB3 CELSR3

1.89e-03111122IPR032471
DomainPKD_channel

PKD1L1 PKDREJ

1.89e-03111122PF08016
DomainGAIN

ADGRB3 CELSR3

1.89e-03111122PF16489
DomainPKD1_2_channel

PKD1L1 PKDREJ

1.89e-03111122IPR013122
DomainWD40_repeat_dom

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

2.09e-032971127IPR017986
DomainC8

VWF MUC19

2.26e-03121122PF08742
DomainTIL

VWF MUC19

2.26e-03121122PF01826
DomainUnchr_dom_Cys-rich

VWF MUC19

2.66e-03131122IPR014853
DomainC8

VWF MUC19

2.66e-03131122SM00832
DomainTIL_dom

VWF MUC19

3.09e-03141122IPR002919
DomainWD40_repeat_CS

RAE1 TEP1 STRAP CIAO1 WDR48

3.10e-031641125IPR019775
Domain7tm_2

VIPR2 ADGRB3 CELSR3

3.35e-03501123PF00002
DomainG_PROTEIN_RECEP_F2_2

VIPR2 ADGRB3 CELSR3

3.35e-03501123PS00650
Domain-

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

3.95e-0333311272.130.10.10
DomainWD40/YVTN_repeat-like_dom

RAE1 TEP1 DCAF8L1 STRAP CIAO1 LRBA WDR48

4.08e-033351127IPR015943
DomainARM-type_fold

GPRASP1 DNAJC13 TNPO2 VEPH1 ARVCF EIF2B5 LRBA

4.35e-033391127IPR016024
DomainMAM

MDGA2 MALRD1

4.57e-03171122SM00137
DomainMAM

MDGA2 MALRD1

5.12e-03181122PF00629
DomainLH2

PKD1L1 PKDREJ

5.12e-03181122SM00308
DomainMAM_dom

MDGA2 MALRD1

5.12e-03181122IPR000998
DomainCTCK_1

VWF MUC19

5.12e-03181122PS01185
DomainMAM_2

MDGA2 MALRD1

5.12e-03181122PS50060
DomainKinase-like_dom

FLT4 KALRN TEX14 MYLK3 IKBKE TBK1 MAPK6 MAP3K7 DNM2

5.34e-035421129IPR011009
DomainGPCR_2_secretin-like

VIPR2 ADGRB3 CELSR3

5.60e-03601123IPR000832
DomainGPCR_2-like

VIPR2 ADGRB3 CELSR3

5.60e-03601123IPR017981
DomainCyclophilin-type_PPIase_CS

RANBP2 PPIE

5.70e-03191122IPR020892
DomainVWC_out

VWF MUC19

5.70e-03191122SM00215
DomainG_PROTEIN_RECEP_F2_4

VIPR2 ADGRB3 CELSR3

5.87e-03611123PS50261
Pubmed

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.

TOPBP1 SMARCA2 SMARCA4

4.11e-083121315075294
Pubmed

BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.

TOPBP1 SMARCA2 SMARCA4

4.11e-083121320571081
Pubmed

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

IKBKE TBK1 NOS2

1.64e-074121324562310
Pubmed

Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene.

SMARCA1 SMARCA2 SMARCA4

8.15e-076121315347669
Pubmed

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.

SMARCA2 SMARCA4 ALAS2

6.64e-0611121318094026
Pubmed

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

SMARCA2 SMARCA4

1.20e-05212128670841
Pubmed

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.

SMARCA2 SMARCA4

1.20e-052121223163725
Pubmed

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

SMARCA2 SMARCA4

1.20e-052121223076393
Pubmed

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

SMARCA2 SMARCA4

1.20e-052121215576411
Pubmed

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.

IKBKE TBK1

1.20e-052121230082428
Pubmed

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

IKBKE TBK1

1.20e-052121216888014
Pubmed

Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

SMARCA2 SMARCA4

1.20e-052121215240517
Pubmed

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

SMARCA2 SMARCA4

1.20e-052121226564006
Pubmed

SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.

SMARCA2 SMARCA4

1.20e-052121233027072
Pubmed

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

SMARCA2 SMARCA4

1.20e-052121223872584
Pubmed

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.

SMARCA2 SMARCA4

1.20e-052121223088494
Pubmed

Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies.

FCER1A IGHE

1.20e-052121218356810
Pubmed

Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits.

P2RX1 P2RX4

1.20e-052121224845338
Pubmed

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

SMARCA2 SMARCA4

1.20e-052121220333683
Pubmed

SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.

SMARCA2 SMARCA4

1.20e-052121234812766
Pubmed

Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.

SMARCA2 SMARCA4

1.20e-052121230478150
Pubmed

Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.

IKBKE TBK1

1.20e-052121217056502
Pubmed

P2X1 and P2X4 receptor currents in mouse macrophages.

P2RX1 P2RX4

1.20e-052121217934511
Pubmed

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

SMARCA2 SMARCA4

1.20e-052121225808524
Pubmed

Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility.

P2RX1 P2RX4

1.20e-052121217873021
Pubmed

Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.

SMARCA2 SMARCA4

1.20e-052121219144648
Pubmed

Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production.

IKBKE TBK1

1.20e-052121224722368
Pubmed

High-affinity IgE receptor on eosinophils is involved in defence against parasites.

FCER1A IGHE

1.20e-05212128114916
Pubmed

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.

SMARCA2 SMARCA4

1.20e-052121229391527
Pubmed

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.

SMARCA2 SMARCA4

1.20e-052121237634210
Pubmed

The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.

IKBKE TBK1

1.20e-052121223157677
Pubmed

Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

SMARCA2 SMARCA4

1.20e-05212128208605
Pubmed

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

SMARCA2 SMARCA4

1.20e-052121211163203
Pubmed

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.

SMARCA2 SMARCA4

1.20e-052121212620226
Pubmed

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

SMARCA2 SMARCA4

1.20e-052121227039070
Pubmed

Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.

SMARCA2 SMARCA4

1.20e-052121229848589
Pubmed

Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.

IKBKE TBK1

1.20e-052121227123832
Pubmed

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

SEC61A2 SEC61A1

1.20e-052121218480044
Pubmed

IKKε and TBK1 expression in gastric cancer.

IKBKE TBK1

1.20e-052121227145266
Pubmed

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.

IKBKE TBK1

1.20e-052121230349097
Pubmed

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

IKBKE TBK1

1.20e-052121215367631
Pubmed

IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.

IKBKE TBK1

1.20e-052121232858764
Pubmed

Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.

SMARCA2 SMARCA4

1.20e-05212129603422
Pubmed

SWI/SNF gene variants and glioma risk and outcome.

SMARCA2 SMARCA4

1.20e-052121223276717
Pubmed

Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.

SMARCA2 SMARCA4

1.20e-052121227097303
Pubmed

SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.

SMARCA2 SMARCA4

1.20e-052121228038711
Pubmed

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.

IKBKE TBK1

1.20e-052121236936901
Pubmed

Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.

IKBKE TBK1

1.20e-052121223096996
Pubmed

Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.

SMARCA2 SMARCA4

1.20e-052121223963727
Pubmed

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

FCER1A IGHE

1.20e-052121221516097
Pubmed

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

IKBKE TBK1

1.20e-052121215210742
Pubmed

SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.

SMARCA2 SMARCA4

1.20e-052121212493776
Pubmed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

SMARCA2 SMARCA4

1.20e-052121231375262
Pubmed

Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.

SMARCA2 SMARCA4

1.20e-052121217075831
Pubmed

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

SMARCA2 SMARCA4

1.20e-052121232855269
Pubmed

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

SMARCA2 SMARCA4

1.20e-052121222721696
Pubmed

Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.

SMARCA2 SMARCA4

1.20e-052121218508913
Pubmed

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

SMARCA2 SMARCA4

1.20e-052121211719516
Pubmed

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.

IKBKE TBK1

1.20e-052121222619329
Pubmed

The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.

IKBKE TBK1

1.20e-052121230504235
Pubmed

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

SMARCA2 SMARCA4

1.20e-052121228706277
Pubmed

[Expression of BRG1 and BRM proteins in prostatic cancer].

SMARCA2 SMARCA4

1.20e-052121221092585
Pubmed

SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

SMARCA2 SMARCA4

1.20e-052121226551623
Pubmed

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SMARCA2 SMARCA4

1.20e-052121219458193
Pubmed

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

IKBKE TBK1

1.20e-052121218353649
Pubmed

Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.

FCER1A IGHE

1.20e-05212128551243
Pubmed

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.

SMARCA2 SMARCA4

1.20e-052121234289068
Pubmed

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

SMARCA2 SMARCA4

1.20e-052121234518526
Pubmed

SMARCA family of genes.

SMARCA2 SMARCA4

1.20e-052121232312722
Pubmed

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

SMARCA2 SMARCA4

1.20e-052121226356327
Pubmed

Crystal structure and mechanism of activation of TANK-binding kinase 1.

IKBKE TBK1

1.20e-052121223453971
Pubmed

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

SMARCA2 SMARCA4

1.20e-052121212566296
Pubmed

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

SMARCA2 SMARCA4

1.20e-052121231406271
Pubmed

Apical P2XR contribute to [Ca2+]i signaling and Isc in mouse renal MCD.

P2RX1 P2RX4

1.20e-052121217560948
Pubmed

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.

SMARCA2 SMARCA4

1.20e-052121229273066
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

SMARCA1 USP7 SMARCA2 SMARCA4

1.55e-0543121426030138
Pubmed

Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.

MED12L SMARCA2 SMARCA4

1.81e-0515121319762545
Pubmed

Interaction network of human early embryonic transcription factors.

RANBP2 RAE1 TNPO2 TBK1 ZNF516 SMARCA1 SMARCA2 SMARCA4

3.32e-05351121838297188
Pubmed

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

SMARCA2 SMARCA4

3.59e-053121230287812
Pubmed

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.

IKBKE TBK1

3.59e-053121229755980
Pubmed

ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.

IKBKE TBK1

3.59e-053121222787218
Pubmed

Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins.

SMARCA4 SLC27A5

3.59e-053121216552721
Pubmed

HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.

IKBKE TBK1

3.59e-053121225531185
Pubmed

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.

P2RX1 P2RX4

3.59e-053121220660288
Pubmed

Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells.

P2RX1 P2RX4

3.59e-053121219552691
Pubmed

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.

SMARCA2 SMARCA4

3.59e-053121215034933
Pubmed

Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.

FCER1A IGHE

3.59e-053121210917520
Pubmed

A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.

SMARCA2 SMARCA4

3.59e-053121212044884
Pubmed

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.

SMARCA2 SMARCA4

3.59e-053121221518954
Pubmed

SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.

IKBKE TBK1

3.59e-053121225939384
Pubmed

Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.

IKBKE TBK1

3.59e-053121216380379
Pubmed

Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies.

IKBKE TBK1

3.59e-053121224335286
Pubmed

Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.

IKBKE TBK1

3.59e-053121234260286
Pubmed

Characterization of mammary tumors from Brg1 heterozygous mice.

SMARCA2 SMARCA4

3.59e-053121217637742
Pubmed

Role of adenosine 5'-triphosphate in regulating renal microvascular function and in hypertension.

P2RX1 P2RX4

3.59e-053121221768526
Pubmed

A20 is a negative regulator of IFN regulatory factor 3 signaling.

IKBKE TBK1

3.59e-053121215661910
Pubmed

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.

SMARCA2 SMARCA4

3.59e-053121228292935
Pubmed

Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.

SMARCA2 SMARCA4

3.59e-053121236464671
Pubmed

Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l.

SMARCA1 SMARCA2

3.59e-053121211359880
Pubmed

USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.

TBK1 USP7

3.59e-053121229688809
Cytoband19p12

ZNF208 ZNF826P ZNF676 ZNF91

9.85e-0590121419p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF208 ZNF826P ZNF676 ZNF91

3.17e-041221214chr19p12
GeneFamilyWD repeat domain containing

RAE1 TEP1 DCAF8L1 STRAP CIAO1 EFCAB8 LRBA WDR48

1.88e-05262798362
GeneFamilyPurinergic receptors P2X

P2RX1 P2RX4

3.90e-047792214
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM64C TRIM45 TRIM13 TRIM51G

7.95e-049579459
ToppCell10x5'-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

SYCP2L EME1 THSD7A TTLL7 MALRD1 FCER1A STXBP6 TEX101

2.01e-081681218650ad3ea52577887885d82457dbc04202ce3eb34
ToppCell10x5'-lymph-node_spleen-Mast|lymph-node_spleen / Manually curated celltypes from each tissue

SYCP2L EME1 THSD7A TTLL7 MALRD1 FCER1A STXBP6 TEX101

2.01e-081681218e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCell3'_v3-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

SYCP2L THSD7A TEX15 TTLL7 FCER1A P2RX1 STXBP6 MED12L

3.44e-081801218b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCellControl-Endothelial|Control / Disease state, Lineage and Cell class

FLT4 VWF KALRN LRATD1 PKHD1L1 TINAGL1 PTPRB STXBP6

6.14e-081941218485fe5538fabec457b9a51feb641f2a91cbf4e18
ToppCellLung_Parenchyma-Control-Endothelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FLT4 VWF THSD7A KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

7.76e-08200121841ac6adbf61763aa8a81a0ed586c4a5542a42cc5
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

FLT4 VWF THSD7A KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

7.76e-0820012185109b417c066ecca0252008206b4f4b7a14c8702
ToppCellParenchyma_Control_(B.)-Endothelial-TX|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

FLT4 VWF THSD7A KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

7.76e-0820012189e5627e11288713aa9b622aae40e849dd6eacd29
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

FLT4 VWF TMC1 THSD7A KALRN PKD1L1 PTPRB

4.62e-071721217c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

FLT4 THSD7A KALRN LRATD1 PKHD1L1 PTPRB NID1

4.81e-071731217dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell3'_v3-bone_marrow-Mast-Mast_cells|bone_marrow / Manually curated celltypes from each tissue

SYCP2L THSD7A TEX15 TTLL7 FCER1A P2RX1 STXBP6

6.51e-07181121730ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF THSD7A MDGA2 TINAGL1 PTPRB RAB34 NID1

7.27e-071841217f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF THSD7A MDGA2 TINAGL1 PTPRB RAB34 NID1

7.27e-0718412178bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Tumor_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

VWF ZNF208 TINAGL1 PTPRB GPR158 NID1 MINDY4

8.11e-0718712172713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCellEndothelial-B|World / lung cells shred on cell class, cell subclass, sample id

FLT4 KALRN LRATD1 PKHD1L1 ZNF676 STXBP6 NID1

8.40e-0718812175959a88728812a5f4cbfa54eddc7a73ccbaa2f68
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

FLT4 THSD7A KALRN LRATD1 PKHD1L1 PTPRB NID1

9.02e-07190121791bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SYCP2L FLT4 VWF THSD7A KALRN PTPRB SIPA1L2

9.34e-0719112172f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellCOPD-Endothelial-Lymphatic|COPD / Disease state, Lineage and Cell class

FLT4 KALRN LRATD1 PKHD1L1 PTPRB SMARCA1 NID1

1.00e-06193121718bcf08068a236c4575c7a07181ac893dfdcbeeb
ToppCellCOPD-Endothelial|COPD / Disease state, Lineage and Cell class

FLT4 VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.00e-061931217093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCellfacs-Heart-LA-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 VWF PKHD1L1 TINAGL1 PTPRB CD38 NOS2

1.04e-06194121733cc4f1d716cb71d54cdedbe9bbdc0d7b17c4777
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT4 VWF KALRN LRATD1 PKHD1L1 PTPRB STXBP6

1.07e-061951217094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB SIPA1L2

1.11e-061961217ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB SIPA1L2

1.11e-061961217b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCellEndothelial|World / Lineage, Cell type, age group and donor

FLT4 VWF KALRN LRATD1 PKHD1L1 PTPRB STXBP6

1.11e-06196121796c6d78482a130ce4e29f6629972a06d10d7530e
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

FLT4 VWF PTPRB STXBP6 SMARCA2 ZNF518B SIPA1L2

1.27e-062001217e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF KALRN GDPD3 PTPRB MYLK3 STXBP6 ARVCF

1.27e-062001217fe493b0454a20498e9ada482bf55de64519f6c35
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

FLT4 VWF PTPRB STXBP6 SMARCA2 ZNF518B SIPA1L2

1.27e-0620012173372c488a39fe812fa94e4f0564594186fea3db5
ToppCellBiopsy_IPF-Endothelial|Biopsy_IPF / Sample group, Lineage and Cell type

FLT4 VWF THSD7A PKHD1L1 TINAGL1 PTPRB STXBP6

1.27e-0620012177ccd3b617838b39da814278dc0e12384013401ce
ToppCelldroplet-Heart-nan-3m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB34 GPR68 MED12L TMEM131L ALAS2 LY75

2.34e-061401216ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

TMC1 ZNF658 GDPD3 PTPRB GPR158 WDR48

4.87e-061591216f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

TMC1 ZNF658 GDPD3 PTPRB GPR158 WDR48

4.87e-061591216929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D122|Adult / Lineage, Cell type, age group and donor

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

5.05e-0616012160cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCellEndothelial-B-HP_01|World / lung cells shred on cell class, cell subclass, sample id

THSD7A KALRN ZNF208 PKHD1L1 ZNF676 STXBP6

6.02e-06165121610087d8bd2985906ef19547fe77eb178ae5e1638
ToppCellEndothelial-B-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

FLT4 LRATD1 ZNF208 PKHD1L1 ZNF676 NID1

6.02e-061651216b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

SYCP2L FLT4 VWF KALRN CELSR3 STXBP6

6.46e-0616712165af9127bae05768a5164d5708a4ad37edca99324
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

GPRASP1 THSD7A KALRN PTPRB MYLK3 P2RX1

6.68e-06168121645ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCellEndothelial-B-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

FLT4 KALRN LRATD1 PKHD1L1 ZNF676 STXBP6

6.68e-0616812164977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCellILEUM-inflamed-(4)_Mast|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SYCP2L MDGA2 FCER1A P2RX1 STXBP6 MAPK6

7.64e-061721216be82f749f4b1049ae8832facc052082cf5463c11
ToppCellILEUM-inflamed-(4)_Mast_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SYCP2L MDGA2 FCER1A P2RX1 STXBP6 MAPK6

7.64e-0617212167185b28282412f3a464b2a8ad5605475a1a31358
ToppCellEndothelial-B-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

FLT4 LRATD1 PKHD1L1 ZNF676 STXBP6 NID1

7.90e-061731216a81992965137195d20fc498f750975303961a828
ToppCellAdult-Endothelial-endothelial_cell_of_vein|Adult / Lineage, Cell type, age group and donor

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

8.71e-061761216043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

FLT4 THSD7A KALRN LRATD1 PKHD1L1 PTPRB

9.29e-061781216c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF THSD7A MDGA2 TTLL7 TINAGL1 PTPRB

9.59e-061791216a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellCOPD-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

9.59e-0617912169968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

VWDE FBXO30 STXBP6 ARVCF MED12L ALAS2

1.02e-0518112169dc0563453e24c9d1d975e2e0e1e272487e19908
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 KALRN TINAGL1 PTPRB NID1 MINDY4

1.02e-051811216fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

VWDE FBXO30 STXBP6 ARVCF MED12L ALAS2

1.02e-05181121614c2dd946e89ba578711c2d25935b6b3d319b701
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

VWDE FBXO30 STXBP6 ARVCF MED12L ALAS2

1.02e-051811216c5843b89f3d362e236ff76c3279518a2fdfc1f75
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

VWDE FBXO30 STXBP6 ARVCF MED12L ALAS2

1.02e-051811216fcefb5902416c004631f4f8dd5c8f99fe3bd90bc
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 VEPH1 ZNF208 STXBP6 CD38 CARD6

1.05e-0518212168d8f28bd43108b2fb3a6c2a3d77a897853d440a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF ADGRB3 PTPRB SIPA1L2

1.12e-051841216688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCellCOPD-Endothelial-VE_Venous|COPD / Disease state, Lineage and Cell class

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.12e-05184121644d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 VWF THSD7A MDGA2 TTLL7 PTPRB

1.16e-051851216f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLT4 VWF PKDREJ PTPRB SMARCA2 NID1

1.19e-051861216a906020a8df6fcca474b278f746c553b177a56b4
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D175|Adult / Lineage, Cell type, age group and donor

FLT4 KALRN PKHD1L1 ZNF676 PTPRB NID1

1.23e-0518712161e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCellfacs-Heart-LV-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 TTLL7 TINAGL1 PTPRB CD38 NOS2

1.27e-051881216ed11e26ff4ef3d6314b5f5734062519b9aa285c1
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

VWF THSD7A KALRN PKHD1L1 PTPRB STXBP6

1.27e-051881216d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellfacs-Heart-LV-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 TTLL7 TINAGL1 PTPRB CD38 NOS2

1.27e-051881216e5a8ca4613ab0bf1584b9e78959adf41d0bf379f
ToppCellfacs-Heart-LV-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 TTLL7 TINAGL1 PTPRB CD38 NOS2

1.27e-0518812160fc3a6562e6895f6fe7a93397eae842a75c60c93
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT4 THSD7A KALRN PKHD1L1 PTPRB STXBP6

1.27e-0518812162db80767903703e7e0a1a37c598f7877a909ee94
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT4 KALRN LRATD1 PKHD1L1 PTPRB NID1

1.27e-051881216aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLT4 VWF THSD7A KALRN ADGRB3 PTPRB

1.31e-051891216c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCellControl-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.31e-051891216f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLT4 VWF PKHD1L1 TINAGL1 PTPRB CD38

1.31e-05189121628b9e96a5206b7fdae9b17daf05c8f5d24b6c5ec
ToppCelltumor_Lung-B_lymphocytes-GC_B_cells_in_the_LZ|B_lymphocytes / Location, Cell class and cell subclass

RANBP2 PTPN18 STXBP6 IGHE CD38 MED12L

1.35e-051901216bfb16efb23add53eebabc8e48f20c96994ec01da
ToppCellControl-Endothelial-VE_Venous|Control / Disease state, Lineage and Cell class

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.39e-051911216617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCellControl-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

FLT4 KALRN LRATD1 PKHD1L1 PTPRB NID1

1.43e-051921216f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 VWF VEPH1 PKHD1L1 PTPRB CD38

1.43e-0519212164e63d95f75fe6eb3f817e84528883e95093c5bbd
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT4 PTPN18 PTPRB CD38 SMARCA2 GNAI2

1.43e-0519212163c8603f977de34ee0d2bb50635f6722112a6a4db
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB

1.43e-051921216c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCellCOPD-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

FLT4 KALRN PKHD1L1 PTPRB SMARCA1 NID1

1.47e-05193121625bdc557055b5bce6a21f8696b48e991c696b979
ToppCell(4)_Endothelial_cells|World / Cell class and subclass of bone marrow stroma cells in homeostatis

FLT4 PTPN18 TINAGL1 PTPRB CD38 NID1

1.47e-051931216ae6ba13d4d9f2a700887cdda2790c32007b29ac8
ToppCellLAM-Endothelial-LymEndo|LAM / Condition, Lineage and Cell class

FLT4 KALRN LRATD1 PKHD1L1 PTPRB NID1

1.47e-05193121668eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.47e-0519312169ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF THSD7A PTPRB STXBP6 SMARCA2 SIPA1L2

1.47e-051931216e1d546165dcc2392f540162206852c4717d7306f
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT4 VWF LRATD1 PTPRB STXBP6 SIPA1L2

1.47e-051931216ad2df9b77999780860141be6ec366afc0172a331
ToppCellIPF-Endothelial-VE_Venous|IPF / Disease state, Lineage and Cell class

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.47e-05193121629a655fa80feaabe846c90a28363b037e22d24ae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB

1.47e-05193121652e918884877b6659cdca0496390e440f73694a9
ToppCellIPF-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.47e-051931216ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCellnucseq-Endothelial-Endothelial_Lymphatic-LEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLT4 KALRN LRATD1 PKHD1L1 PTPRB NID1

1.51e-051941216f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB

1.51e-051941216f76808666fb875fc787751cbfd924d9be20a8192
ToppCellnucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLT4 KALRN LRATD1 PKHD1L1 PTPRB NID1

1.51e-0519412163b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCellIPF-Endothelial|IPF / Disease state, Lineage and Cell class

VWF THSD7A KALRN PKHD1L1 TINAGL1 PTPRB

1.51e-0519412169591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCellnucseq-Endothelial-Endothelial_Lymphatic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLT4 KALRN LRATD1 PKHD1L1 PTPRB NID1

1.51e-0519412165d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCellAdult-Endothelial|Adult / Lineage, Cell type, age group and donor

FLT4 VWF KALRN PKHD1L1 PTPRB STXBP6

1.51e-051941216963b3fbee0575af8379baa397ace65949eaf34f7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB

1.51e-051941216f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 VWF KALRN ADGRB3 PTPRB NOS2

1.51e-051941216e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYCP2L FLT4 VWF KALRN ADGRB3 PTPRB

1.51e-051941216a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SYCP2L FLT4 VWF KALRN PTPRB SIPA1L2

1.56e-051951216a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLT4 VWF PTPRB STXBP6 NID1 NOS2

1.56e-05195121622a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCellBronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VIPR2 MPEG1 FCER1A P2RX1 KLRF2 MED12L

1.56e-051951216fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 VWF KALRN ADGRB3 PTPRB NOS2

1.61e-051961216023312af38f816a44b407e0daa32590d953caf99
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 VWF KALRN ADGRB3 PKHD1L1 PTPRB

1.61e-05196121622767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCelldroplet-Liver-LIVER-NPC-1m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 TINAGL1 PTPRB CD38 NID1 GNAI2

1.61e-0519612160dfa2dc1ec527d40005614c00ed0e5f3a566c2e2
ToppCellFetal_29-31_weeks-Endothelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT4 VWF LRATD1 PKHD1L1 PTPRB STXBP6

1.61e-0519612163981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 VWF KALRN ADGRB3 PKHD1L1 PTPRB

1.61e-051961216adee900dcd16dbaba15c58bdcace09ba20214950
ToppCelldroplet-Liver-LIVER-NPC|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 TINAGL1 PTPRB CD38 NID1 GNAI2

1.61e-051961216a3513c91afdc2d363e1c57071ae2399f9b7e6263
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 VWF THSD7A PKHD1L1 PTPRB GNAI2

1.61e-051961216629236f95c838a473b5964a49b7c1b7ad863ea12
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FLT4 VWF THSD7A TINAGL1 PTPRB NID1

1.65e-051971216f1080d93acf1a4756d2f2c8cabd1fb50bc7bcd09
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

VWF THSD7A KALRN PKHD1L1 TINAGL1 PTPRB

1.65e-051971216f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF KALRN PKHD1L1 TINAGL1 PTPRB STXBP6

1.65e-051971216b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

KANSL1L TEX15 PTPN18 TTLL7 TRIM45 CELSR3 SMARCA2 WDR48

5.46e-0619111481227_UP
DrugProgesterone [57-83-0]; Up 200; 12.8uM; PC3; HT_HG-U133A

KANSL1L KALRN ADGRB3 TRIM45 PTPRB ARVCF SCN10A MASP2

6.60e-0619611486646_UP
DiseaseCoffin-Siris syndrome

SMARCA1 SMARCA2 SMARCA4

1.69e-05131173C0265338
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCA2 SMARCA4

1.55e-0451172C3281201
DiseaseVertigo

SYCP2L MALRD1 MED12L ZNF91 NOS2

2.37e-041391175HP_0002321
DiseaseAlzheimer disease, gastroesophageal reflux disease

VIPR2 THSD7A ADGRB3 DNAH12 LRRC25 STXBP6

3.05e-042281176EFO_0003948, MONDO_0004975
Diseasemultiple system atrophy

MDGA2 PKHD1L1 CARD6

5.39e-04401173EFO_1001050
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCA2 SMARCA4

5.51e-0491172DOID:0050340 (implicated_via_orthology)
Diseasemacrophage migration inhibitory factor measurement

ZNF208 MDGA2 USP7

6.68e-04431173EFO_0008221
Diseasethyroid gland carcinoma (is_marker_for)

FLT4 PTPRB

1.00e-03121172DOID:3963 (is_marker_for)
Diseasebrain disease (is_implicated_in)

RANBP2 TBK1

1.00e-03121172DOID:936 (is_implicated_in)
Diseaseacute graft vs. host disease, donor genotype effect measurement

KALRN MDGA2

1.58e-03151172EFO_0004599, EFO_0007892
Diseaseplatelet measurement

VWF KALRN P2RX1 MED12L TMEM131L LY75

1.64e-033151176EFO_0005036
Diseaseenergy expenditure measurement

GPR158 USP7

2.83e-03201172EFO_0008005
DiseaseSarcoma

FLT4 SMARCA4

3.12e-03211172C1261473
Diseasecolorectal carcinoma (is_implicated_in)

PTPRB STRAP

3.42e-03221172DOID:0080199 (is_implicated_in)
Diseaseremission, hepatitis C virus infection

MALRD1 GPR158

3.73e-03231172EFO_0003047, EFO_0009785

Protein segments in the cluster

PeptideGeneStartEntry
LAGEFSDIQACSAAW

PTPN18

26

Q99952
KSCEAAQYWSSGFTV

ABCA5

161

Q8WWZ7
CNGNNFFEVSSTKWF

FCER1A

51

P12319
FWIGKDSSQDEQSCA

AVIL

61

O75366
RDAEWTTVFKNTSGC

ARVCF

511

O00192
GFNAAQDFWCSTLVK

ADGRB3

21

O60242
DSCSWAAFGDQQATE

AFTPH

581

Q6ULP2
AAATFSVGWNTFACS

ABHD3

241

Q8WU67
SVGWNTFACSESLEK

ABHD3

246

Q8WU67
ADKTEPECFAASWTF

LINC01587

61

Q99440
DCQSVWDAFKGAFIS

CD38

81

P28907
DVCWSDDGSKVFTAS

RAE1

91

P78406
DFRSVFSTKEGQWDC

RANBP2

1471

P49792
FSTKEGQWDCSACLV

RANBP2

1476

P49792
AFNGSVKTCEVAAWC

P2RX4

151

Q99571
WDTAGQERFKCIAST

RAB34

106

Q9BZG1
AKAEFRAFWCVASSQ

MPEG1

456

Q2M385
SWAVQTFKAACETFD

NOS2

671

P35228
WSENKSISFAGCVAQ

OR9K2

111

Q8NGE7
IFSEDTTFKWDSCAA

INPP1

306

P49441
KSSINFTVNCSWFSD

PTPRB

1466

P23467
FTVNCSWFSDTNGAV

PTPRB

1471

P23467
CKASGFTFTSSAVQW

IGHV1-58

41

A0A0C4DH39
WDDAKNGFARCTAAE

KANSL1L

306

A0AUZ9
RWSFDKCQESTAGVT

MED12L

441

Q86YW9
SSFAYISWKFECGSV

NGLY1

546

Q96IV0
QKVDIDQCSSDGWFS

GPR158

311

Q5T848
DVDWNAEFSATCLNF

LRRC25

31

Q8N386
KGVWTQEDENSCSFS

LMO7DN

6

F2Z398
KCWGFDQFFAETSDI

IKBKE

291

Q14164
TGVQETFVFCCWKAA

EIF2B5

86

Q13144
SSWDSQFVSGGEDCF

MAPK6

591

Q16659
TDFFWEQKTISFVGC

OR5A1

86

Q8NGJ0
FGNSWKTSQECSDTV

MUC19

1436

Q7Z5P9
NCSWDFDADTFEGLS

MYLK3

726

Q32MK0
FDAFSSQLCWVDAGT

NID1

1116

P14543
EDVGHCFVTWADKFQ

KALRN

1356

O60229
FEGSNYSEKCDVFSW

MAP3K7

201

O43318
DVFGFSETAGAWQCF

VEPH1

686

Q14D04
ASSGAWACFDEFNRI

DNAH12

1296

Q6ZR08
TWFVNTSDTFDKCFL

LRBA

331

P50851
DAESGLWQSFSCEAQ

LY75

321

O60449
GLKSEEICWTNSESF

LRATD1

201

Q96KN4
FWCLNEESDFEAAFS

GDPD3

276

Q7L5L3
ACDSQEDVDSWKASF

DNM2

606

P50570
FSEASVASKDVSVWC

ALAS2

181

P22557
CLFTQDDTDNFDWTK

MDGA2

756

Q7Z553
NQTSASKVGSFFDDW

ETAA1

566

Q9NY74
FASEACVGSKFWEQS

GBA

376

P04062
FEANSCDWFEAISGD

MALRD1

656

Q5VYJ5
EGFAKECSWRTQSFN

DNAJB7

231

Q7Z6W7
TGNWVYSEDCSSTFK

KLRF2

176

D3W0D1
SAVFFFTDCLGEKEW

CARD6

551

Q9BX69
ESVWGDEKSSFICNT

GJB1

41

P08034
GVECVSSFAVDFWLQ

DNAJC13

1521

O75165
AKNCSQVWAEALSDF

FAM166B

106

A8MTA8
WVDNKTFSVCSRDFT

IGHE

96

P01854
NDGKYVCEADGFWTS

MASP2

406

O00187
FLKVDSDCEGFVTWQ

EFCAB8

96

A8MWE9
GSDCGHVFFWEKSSS

DCAF8L1

456

A6NGE4
VQSWKELADFTCAFT

EME1

426

Q96AY2
CKNSGFCSERWGSFS

CELSR3

1731

Q9NYQ7
RFSTAFCSVNEWKFA

FBXO30

681

Q8TB52
SQFFLTCDKTDWLDG

PPIE

246

Q9UNP9
ASVAFECWINFGTDV

PKD1L1

606

Q8TDX9
RSVWEASCDFAKGVF

GPR68

251

Q15743
AFNDTVKTCEIFGWC

P2RX1

151

P51575
AGAEETNNKSCFWAE

GPRASP1

666

Q5JY77
DWSSCGENYFLNTKE

SYDE2

1091

Q5VT97
YFAEGTCSSNLKSVW

MEIOC

151

A2RUB1
FNEKSECTWTGGQSA

TRIM45

556

Q9H8W5
CAGSWAFSTAAVASD

TINAGL1

226

Q9GZM7
ESITFQVKTEFASCW

TEX14

1231

Q8IWB6
SCAFFSKTWIEVSGS

SEC61A2

371

Q9H9S3
TIFKSCSTFEQWFNA

SMARCA2

901

P51531
DDFDSWFDTKNCLGD

SMARCA1

366

P28370
SWSKFSSCNGDCGAV

THSD7A

911

Q9UPZ6
NSFIDWSATCEGQFS

TMEM131L

1441

A2VDJ0
WDCTGAFSDELSFKR

SKAP2

306

O75563
KSIEWLFASFCSFCQ

PKDREJ

1606

Q9NTG1
FDSICNNKWFTDTSI

GNAI2

251

P04899
TIFKSCSTFEQWFNA

SMARCA4

931

P51532
FWFSDGSLSDKSKCA

SIPA1L2

1546

Q9P2F8
TAAADFTAKVWDAVS

STRAP

76

Q9Y3F4
GDDNTFNFSWKVFTS

TMC1

306

Q8TDI8
SCSDDGEVAFWKYQR

CIAO1

321

O76071
GAETWFDSYDCSKFV

CLN5

221

O75503
FGSSCYFISSEEKVW

CLEC6A

86

Q6EIG7
TACATWQFLFSTTKD

VWDE

111

Q8N2E2
EVCGQAFSQTWFLKA

ZNF516

251

Q92618
NAFDQWVASTASEKC

STXBP6

106

Q8NFX7
WVASTASEKCTFFQI

STXBP6

111

Q8NFX7
CEENGKAFNWSSTLT

ZNF676

171

Q8N7Q3
CEECGKAFTWSSSFT

ZNF676

451

Q8N7Q3
SDCFAAWVSAKDAGF

WDR48

436

Q8TAF3
EECGKAFNWSSDFNK

ZNF826P

151

Q6ZT77
FDDLATWKGCLSNFS

TRIM13

341

O60858
FGNSWKVSSQCADTR

VWF

1021

P04275
QLWKTCDADASGTFR

TEP1

1521

Q99973
GSSFCCFNEEWKLQS

MINDY4

421

Q4G0A6
CVLAPKFSTSCFWDD

SLC27A5

356

Q9Y2P5
SCAFFSKTWIEVSGS

SEC61A1

371

P61619
DCKIQNSTGSFFWVN

SCN10A

1331

Q9Y5Y9
EFWGKQSADLQSFCD

SYCP2L

786

Q5T4T6
FFCDAVASWVSPKDD

TNPO2

841

O14787
NCTVWAEFNSGVTFD

FLT4

251

P35916
FADWFPDNVKTAVCD

TUBB8B

341

A6NNZ2
NECWKTFSCSSSFTV

ZNF620

311

Q6ZNG0
DSFCNDKDSLSQFWE

TEX101

111

Q9BY14
ECAEFGKSFTWKSQF

ZNF585B

131

Q52M93
LGSCNDSKLEFRSFW

S100A14

71

Q9HCY8
GDFTKDWVEYNCNSS

TMEM168

586

Q9H0V1
INSWECTFNAKSFRT

PKHD1L1

131

Q86WI1
KNCTSDGWSETFPDF

VIPR2

91

P41587
WKFQTLEESFECDGS

ZNF658

206

Q5TYW1
GWSAFESNKCEENFS

ZNF658

321

Q5TYW1
DCFSKSLNIFGSSWS

ATP6V0A1

466

Q93050
CEECGKAFNWSSSLT

ZNF91

436

Q05481
ITDKSECFLQWGADF

TRIM51G

321

A0A3B3IT33
EECGKAFSWLSVFSK

ZNF208

1256

O43345
SFSFLKDNSTDVCLW

TEX15

2111

Q9BXT5
WNSLFCGFVFDDVSA

TMTC3

21

Q6ZXV5
ESFAVWCAQAFTSGK

TRIM64C

326

A6NLI5
CVTTQWFFDSIEKGF

TOPBP1

261

Q92547
GFFLQCNAESDSTSW

USP7

116

Q93009
FCDSGSSWESIFNKS

TTLL7

786

Q6ZT98
KCWGFDQFFAETSDI

TBK1

291

Q9UHD2
SLPDDSSQCVFKCWF

ZNF518B

1026

Q9C0D4
TGWSAFESNKCEENF

ZNF658B

76

Q4V348