Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microtubule motor activity	DNAH3 DNAH7 KIF9 KIF5A KIF5C	3.69e-05	70	107	5	GO:0003777
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	1.69e-04	4	107	2	GO:0005219
GeneOntologyMolecularFunction	arachidonate 12(S)-lipoxygenase activity	ALOX12 ALOX12B	1.69e-04	4	107	2	GO:0004052
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	4.21e-04	6	107	2	GO:0048763
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH3 DNAH7 KIF9 KIF5A KIF5C	4.35e-04	118	107	5	GO:0003774
GeneOntologyMolecularFunction	ATP hydrolysis activity	DNAH3 DNAH7 KIF9 MDN1 MACF1 DHX35 KIF5A KIF5C XRCC6	6.12e-04	441	107	9	GO:0016887
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1E RYR1 RYR3 SLC24A1	6.54e-04	129	107	5	GO:0005262
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1E	9.99e-04	9	107	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1E	9.99e-04	9	107	2	GO:0099626
GeneOntologyCellularComponent	axon cytoplasm	AP3M1 AP3M2 KIF5A KIF5C	3.96e-04	68	106	4	GO:1904115
GeneOntologyCellularComponent	sarcolemma	RYR1 RYR3 IGF1R KCNJ3 ALOX12 AHNAK2	4.19e-04	190	106	6	GO:0042383
GeneOntologyCellularComponent	calcium channel complex	CACNA1A CACNA1E RYR1 RYR3	5.20e-04	73	106	4	GO:0034704
GeneOntologyCellularComponent	T-tubule	RYR1 IGF1R KCNJ3 AHNAK2	7.01e-04	79	106	4	GO:0030315
GeneOntologyCellularComponent	junctional membrane complex	RYR1 RYR3	8.96e-04	9	106	2	GO:0030314
GeneOntologyCellularComponent	inner dynein arm	DNAH3 DNAH7	1.12e-03	10	106	2	GO:0036156
GeneOntologyCellularComponent	bBAF complex	ARID1A ARID1B	1.12e-03	10	106	2	GO:0140092
GeneOntologyCellularComponent	microtubule associated complex	DNAH3 DNAH7 KIF9 KIF5A KIF5C	1.38e-03	161	106	5	GO:0005875
GeneOntologyCellularComponent	smooth endoplasmic reticulum	GBA2 RYR1 RYR3	1.64e-03	46	106	3	GO:0005790
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CACNA1E RYR1	1.64e-03	46	106	3	GO:0005891
GeneOntologyCellularComponent	AP-3 adaptor complex	AP3M1 AP3M2	1.92e-03	13	106	2	GO:0030123
GeneOntologyCellularComponent	kinesin complex	KIF9 KIF5A KIF5C	1.97e-03	49	106	3	GO:0005871
GeneOntologyCellularComponent	npBAF complex	ARID1A ARID1B	2.23e-03	14	106	2	GO:0071564
GeneOntologyCellularComponent	brahma complex	ARID1A ARID1B	2.23e-03	14	106	2	GO:0035060
GeneOntologyCellularComponent	neuron projection cytoplasm	AP3M1 AP3M2 KIF5A KIF5C	2.39e-03	110	106	4	GO:0120111
GeneOntologyCellularComponent	sarcoplasm	BCL9 RYR1 RYR3 IFRD1	2.72e-03	114	106	4	GO:0016528
GeneOntologyCellularComponent	ciliary rootlet	KIF5A KIF5C	2.92e-03	16	106	2	GO:0035253
GeneOntologyCellularComponent	nBAF complex	ARID1A ARID1B	2.92e-03	16	106	2	GO:0071565
Domain	BAF250/Osa	ARID1A ARID1B	3.25e-05	2	107	2	IPR021906
Domain	BAF250_C	ARID1A ARID1B	3.25e-05	2	107	2	IPR033388
Domain	BAF250_C	ARID1A ARID1B	3.25e-05	2	107	2	PF12031
Domain	Ryanodine_rcpt	RYR1 RYR3	9.72e-05	3	107	2	IPR003032
Domain	Ryanrecept_TM4-6	RYR1 RYR3	9.72e-05	3	107	2	IPR009460
Domain	RyR	RYR1 RYR3	9.72e-05	3	107	2	PF02026
Domain	RR_TM4-6	RYR1 RYR3	9.72e-05	3	107	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	9.72e-05	3	107	2	IPR013333
Domain	EF_hand_dom	CACNA1E DNAH7 RYR1 RYR3 ITSN2 MACF1 TNNC1	3.79e-04	232	107	7	IPR002048
Domain	RIH_assoc-dom	RYR1 RYR3	4.80e-04	6	107	2	IPR013662
Domain	LipOase_mml	ALOX12 ALOX12B	4.80e-04	6	107	2	IPR001885
Domain	LIPOXYGENASE_1	ALOX12 ALOX12B	4.80e-04	6	107	2	PS00711
Domain	LipOase_C	ALOX12 ALOX12B	4.80e-04	6	107	2	IPR013819
Domain	Clathrin_mu_CS	AP3M1 AP3M2	4.80e-04	6	107	2	IPR018240
Domain	CLAT_ADAPTOR_M_1	AP3M1 AP3M2	4.80e-04	6	107	2	PS00990
Domain	CLAT_ADAPTOR_M_2	AP3M1 AP3M2	4.80e-04	6	107	2	PS00991
Domain	LIPOXYGENASE_2	ALOX12 ALOX12B	4.80e-04	6	107	2	PS00081
Domain	LipOase_Fe_BS	ALOX12 ALOX12B	4.80e-04	6	107	2	IPR020833
Domain	LipOase_CS	ALOX12 ALOX12B	4.80e-04	6	107	2	IPR020834
Domain	Ins145_P3_rec	RYR1 RYR3	4.80e-04	6	107	2	PF08709
Domain	RIH_assoc	RYR1 RYR3	4.80e-04	6	107	2	PF08454
Domain	RIH_dom	RYR1 RYR3	4.80e-04	6	107	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	4.80e-04	6	107	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	4.80e-04	6	107	2	IPR015925
Domain	Lipoxygenase	ALOX12 ALOX12B	4.80e-04	6	107	2	PF00305
Domain	LIPOXYGENASE_3	ALOX12 ALOX12B	4.80e-04	6	107	2	PS51393
Domain	-	RYR1 RYR3	4.80e-04	6	107	2	1.25.10.30
Domain	LipOase	ALOX12 ALOX12B	4.80e-04	6	107	2	IPR000907
Domain	RYDR_ITPR	RYR1 RYR3	4.80e-04	6	107	2	PF01365
Domain	Ca_chan_IQ	CACNA1A CACNA1E	6.70e-04	7	107	2	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1E	6.70e-04	7	107	2	PF08763
Domain	VDCC_a1su_IQ	CACNA1A CACNA1E	6.70e-04	7	107	2	IPR014873
Domain	GPHH	CACNA1A CACNA1E	6.70e-04	7	107	2	PF16905
Domain	GPHH_dom	CACNA1A CACNA1E	6.70e-04	7	107	2	IPR031649
Domain	MIR	RYR1 RYR3	1.42e-03	10	107	2	PF02815
Domain	MIR_motif	RYR1 RYR3	1.42e-03	10	107	2	IPR016093
Domain	MIR	RYR1 RYR3	1.42e-03	10	107	2	PS50919
Domain	MIR	RYR1 RYR3	1.42e-03	10	107	2	SM00472
Domain	VDCCAlpha1	CACNA1A CACNA1E	1.42e-03	10	107	2	IPR002077
Domain	Clathrin_mu	AP3M1 AP3M2	1.42e-03	10	107	2	IPR001392
Domain	Kinesin_motor_CS	KIF9 KIF5A KIF5C	1.66e-03	41	107	3	IPR019821
Domain	Adap_comp_sub	AP3M1 AP3M2	1.73e-03	11	107	2	PF00928
Domain	Kinesin-like_fam	KIF9 KIF5A KIF5C	1.91e-03	43	107	3	IPR027640
Domain	-	KIF9 KIF5A KIF5C	2.04e-03	44	107	3	3.40.850.10
Domain	Kinesin	KIF9 KIF5A KIF5C	2.04e-03	44	107	3	PF00225
Domain	KISc	KIF9 KIF5A KIF5C	2.04e-03	44	107	3	SM00129
Domain	KINESIN_MOTOR_1	KIF9 KIF5A KIF5C	2.04e-03	44	107	3	PS00411
Domain	Kinesin_motor_dom	KIF9 KIF5A KIF5C	2.04e-03	44	107	3	IPR001752
Domain	KINESIN_MOTOR_2	KIF9 KIF5A KIF5C	2.04e-03	44	107	3	PS50067
Domain	Clathrin_sm-chain_CS	AP3M1 AP3M2	2.07e-03	12	107	2	IPR000804
Domain	MHD	AP3M1 AP3M2	2.43e-03	13	107	2	PS51072
Domain	MHD	AP3M1 AP3M2	2.43e-03	13	107	2	IPR028565
Domain	6-hairpin_glycosidase-like	GBA2 MOGS	2.43e-03	13	107	2	IPR008928
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH7	2.83e-03	14	107	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH7	2.83e-03	14	107	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH7	2.83e-03	14	107	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH7	2.83e-03	14	107	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH3 MDN1	2.83e-03	14	107	2	IPR011704
Domain	MT	DNAH3 DNAH7	2.83e-03	14	107	2	PF12777
Domain	AAA_8	DNAH3 DNAH7	2.83e-03	14	107	2	PF12780
Domain	AAA_5	DNAH3 MDN1	2.83e-03	14	107	2	PF07728
Domain	DHC_fam	DNAH3 DNAH7	3.25e-03	15	107	2	IPR026983
Domain	-	ARID1A ARID1B	3.25e-03	15	107	2	1.10.150.60
Domain	BRIGHT	ARID1A ARID1B	3.25e-03	15	107	2	SM00501
Domain	BAR	ARHGEF38 DNMBP	3.25e-03	15	107	2	SM00721
Domain	ARID_dom	ARID1A ARID1B	3.25e-03	15	107	2	IPR001606
Domain	ARID	ARID1A ARID1B	3.25e-03	15	107	2	PS51011
Domain	Dynein_heavy	DNAH3 DNAH7	3.25e-03	15	107	2	PF03028
Domain	ARID	ARID1A ARID1B	3.25e-03	15	107	2	PF01388
Domain	Dynein_heavy_dom	DNAH3 DNAH7	3.25e-03	15	107	2	IPR004273
Domain	AP_mu_sigma_su	AP3M1 AP3M2	3.70e-03	16	107	2	IPR022775
Domain	BAR_dom	ARHGEF38 DNMBP	3.70e-03	16	107	2	IPR004148
Domain	Clat_adaptor_s	AP3M1 AP3M2	3.70e-03	16	107	2	PF01217
Domain	Ion_trans_dom	CACNA1A CACNA1E RYR1 RYR3	4.19e-03	114	107	4	IPR005821
Domain	Ion_trans	CACNA1A CACNA1E RYR1 RYR3	4.19e-03	114	107	4	PF00520
Domain	ARM-like	ARID1A ARMC2 IFRD1 ARID1B MROH7 MN1	4.62e-03	270	107	6	IPR011989
Domain	Sulfatase	ARSK PIGG	4.69e-03	18	107	2	PF00884
Domain	LH2	ALOX12 ALOX12B	4.69e-03	18	107	2	SM00308
Domain	Sulfatase_N	ARSK PIGG	4.69e-03	18	107	2	IPR000917
Domain	BAR	ARHGEF38 DNMBP	5.22e-03	19	107	2	PS51021
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1A CACNA1E RYR1 RYR3	2.93e-07	11	79	4	M47958
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NCOA2 ROBO4 PON2 ADAM30 BCL9 ARID1A AP3M1 DNAH7 TMEM200A RYR1 ARID1B MDN1 ITSN2 FECH PCK2 AHNAK2	1.68e-10	638	109	16	31182584
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	NCOA2 WDR33 PON2 BCL9 ARID1A ANKHD1 AP3M1 ARID1B MOGS MCM3AP FUBP3 PCK2	2.28e-08	457	109	12	32344865
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	CACNA1A RYR1 RYR3	2.99e-08	3	109	3	18313230
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	NCOA2 CACNA1A CACNA1E DNAH3 DACH1 MAGEE1 ANKHD1 DNAH7 KIF5A	5.55e-08	233	109	9	37704626
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOA2 CACNA1A CACNA1E BCL9 EEF2 MDN1 DCHS1 MACF1 KIF5A KIF5C FRMPD3 HERC2 RAPGEF2 XRCC6 EPB41L2	3.48e-07	963	109	15	28671696
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NCOA2 PDGFRB APBB2 ZNF521 ARID1A YARS1 RYR3 EEF2 MACF1 DHX35 KIF5A KIF5C HERC2 RAPGEF2 USPL1 MTUS2 XRCC6	5.29e-07	1285	109	17	35914814
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	PRPF31 WDR33 RPS2 MRPL13 FAM98A ANKHD1 TRUB2 PPP1R10 EEF2 MACF1 FUBP3 XRCC6 MBNL3	1.55e-06	807	109	13	22681889
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIGG BCL9 ARID1A ANKHD1 GBA2 RYR1 IGF1R MDN1 PLEKHO2 MCM3AP NLRC5 HERC2 DNMBP WDR24 AHNAK2	1.93e-06	1105	109	15	35748872
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	DNAH3 WDR33 RPS2 FAM98A ARID1A TMEM200A MDN1 FECH MACF1 KIF5A KIF5C XRCC6 EPB41L2	2.63e-06	847	109	13	35235311
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	PRPF31 WDR33 RPS2 MRPL13 FAM98A ANKHD1 YARS1 EEF2 KIF9 TBRG1 FUBP3 XRCC6	2.96e-06	723	109	12	34133714
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PRPF31 FAM98A FNBP1L ANKHD1 PPP1R10 TBRG1 MACF1 DHX35 DNMBP NNT FUBP3 AHNAK2	3.01e-06	724	109	12	36232890
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PRPF31 UAP1 FAM98A DNAH7 IFRD1 IGF1R MDN1 MACF1 KIF5C RAPGEF2 DNMBP EPB41L2 AHNAK2	3.15e-06	861	109	13	36931259
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NCOA2 SH3BP2 ARHGEF38 APBB2 PON2 FNBP1L ARID1A ARMC2 IFRD1 IGF1R KCNJ3 FECH NLRC5 MACF1 KIF5C RAPGEF2 AADAT	3.90e-06	1489	109	17	28611215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	WDR33 RPS2 DACH1 MRPL13 TRUB2 YARS1 MDN1 ITSN2 FECH DHX35 HERC2 PIH1D1 NNT FUBP3 PCK2 XRCC6 AHNAK2	4.15e-06	1496	109	17	32877691
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PRPF31 RPS2 FAM98A ARID1A ANKHD1 EEF2 MDN1 MCM3AP MACF1 HERC2 FUBP3 ALOX12B PCK2 XRCC6 EPB41L2 AHNAK2	4.98e-06	1353	109	16	29467282
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1A CACNA1E RYR1 RYR3	6.21e-06	38	109	4	30786075
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOA2 DACH1 BCL9 ARID1A ARID1B	6.59e-06	83	109	5	28794006
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RPS2 ARID1A ANKHD1 MDN1 MCM3AP MACF1 HERC2 NNT FUBP3 XRCC6 EPB41L2	6.83e-06	653	109	11	22586326
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	UAP1 RPS2 DACH1 ARID1A MDN1 NLRC5 CDYL HERC2 TNNC1 EPB41L2	7.22e-06	533	109	10	30554943
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	CACNA1E SYN3 RPS2 GPRIN1 EEF2 MACF1 EPB41L2	8.73e-06	231	109	7	16452087
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	UAP1 RPS2 TMEM200A RYR1 EEF2 ARID1B MDN1 MOGS MACF1 NNT XRCC6 AHNAK2	9.00e-06	807	109	12	30575818
Pubmed	Tuba stimulates intracellular N-WASP-dependent actin assembly.	FNBP1L DNMBP	9.73e-06	2	109	2	16757518
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	9.73e-06	2	109	2	9489997
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	9.73e-06	2	109	2	12640042
Pubmed	Serum starvation and growth factor receptor expression in vascular smooth muscle cells.	PDGFRB IGF1R	9.73e-06	2	109	2	16407661
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	9.73e-06	2	109	2	14592949
Pubmed	New approach to capture and characterize synaptic proteome.	KIF5A KIF5C	9.73e-06	2	109	2	25352669
Pubmed	Dissecting the role of SWI/SNF component ARID1B in steady-state hematopoiesis.	ARID1A ARID1B	9.73e-06	2	109	2	37611161
Pubmed	Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer.	ARID1A ARID1B	9.73e-06	2	109	2	32791957
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	9.73e-06	2	109	2	9799464
Pubmed	Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers.	ARID1A ARID1B	9.73e-06	2	109	2	28967863
Pubmed	The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons.	KIF5C FUBP3	9.73e-06	2	109	2	23121659
Pubmed	Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function.	NCOA2 PPARGC1A	9.73e-06	2	109	2	37540802
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	9.73e-06	2	109	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	9.73e-06	2	109	2	11500519
Pubmed	Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes.	ARID1A ARID1B	9.73e-06	2	109	2	34386776
Pubmed	Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.	ARID1A ARID1B	9.73e-06	2	109	2	23202128
Pubmed	ARID1 proteins: from transcriptional and post-translational regulation to carcinogenesis and potential therapeutics.	ARID1A ARID1B	9.73e-06	2	109	2	33890484
Pubmed	Chromosomal mapping of genes involved in growth control.	PDGFRB IGF1R	9.73e-06	2	109	2	3107886
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	9.73e-06	2	109	2	16381801
Pubmed	Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.	ALOX12 ALOX12B	9.73e-06	2	109	2	18086569
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	9.73e-06	2	109	2	12565913
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	9.73e-06	2	109	2	9192302
Pubmed	ARID1B is a specific vulnerability in ARID1A-mutant cancers.	ARID1A ARID1B	9.73e-06	2	109	2	24562383
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	9.73e-06	2	109	2	7556644
Pubmed	ARID1B as a Potential Therapeutic Target for ARID1A-Mutant Ovarian Clear Cell Carcinoma.	ARID1A ARID1B	9.73e-06	2	109	2	29890703
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	9.73e-06	2	109	2	15894801
Pubmed	SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability.	ARID1A ARID1B	9.73e-06	2	109	2	24788099
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	9.73e-06	2	109	2	9817784
Pubmed	Establishment and characterization of VOA1066 cells: An undifferentiated endometrial carcinoma cell line.	ARID1A ARID1B	9.73e-06	2	109	2	33052929
Pubmed	Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes.	ALOX12 ALOX12B	9.73e-06	2	109	2	11256953
Pubmed	Characterization of epidermal 12(S) and 12(R) lipoxygenases.	ALOX12 ALOX12B	9.73e-06	2	109	2	12664578
Pubmed	Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas.	ARID1A ARID1B	9.73e-06	2	109	2	27562491
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	NCOA2 IGF1R FECH HERC2 RAPGEF2 DNMBP NNT RUBCN	2.31e-05	371	109	8	15747579
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	WDR33 FAM98A ANKHD1 AP3M1 TRUB2 PPP1R10 EEF2 MOGS MCM3AP HERC2 FUBP3 PCK2 XRCC6 MBNL3 EPB41L2	2.51e-05	1371	109	15	36244648
Pubmed	Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes.	KIF5A KIF5C	2.91e-05	3	109	2	17693257
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	2.91e-05	3	109	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	2.91e-05	3	109	2	11171121
Pubmed	Dynamics of expression of ARID1A and ARID1B subunits in mouse embryos and in cells during the cell cycle.	ARID1A ARID1B	2.91e-05	3	109	2	21647563
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	2.91e-05	3	109	2	7876312
Pubmed	Cloning and localization of a conventional kinesin motor expressed exclusively in neurons.	KIF5A KIF5C	2.91e-05	3	109	2	7514426
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1E	2.91e-05	3	109	2	38996073
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	2.91e-05	3	109	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	2.91e-05	3	109	2	10788707
Pubmed	PGC-1 alpha interacts with microRNA-217 to functionally regulate breast cancer cell proliferation.	DACH1 PPARGC1A	2.91e-05	3	109	2	27916422
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	2.91e-05	3	109	2	7621815
Pubmed	Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport.	KIF5A KIF5C	2.91e-05	3	109	2	21768290
Pubmed	Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.	KIF5A KIF5C	2.91e-05	3	109	2	30068641
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	2.91e-05	3	109	2	10473538
Pubmed	ARID1A, ARID1B, and ARID2 Mutations Serve as Potential Biomarkers for Immune Checkpoint Blockade in Patients With Non-Small Cell Lung Cancer.	ARID1A ARID1B	2.91e-05	3	109	2	34512623
Pubmed	DNA damage induces down-regulation of PEPCK and G6P gene expression through degradation of PGC-1alpha.	PPARGC1A PCK2	2.91e-05	3	109	2	21733854
Pubmed	Loss of ARID1B and SMARCB1 expression are specific for the diagnosis of dedifferentiated/undifferentiated carcinoma in tumours of the upper gynaecological tract and cervix.	ARID1A ARID1B	2.91e-05	3	109	2	33432679
Pubmed	Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells.	PDGFRB IGF1R	2.91e-05	3	109	2	17568996
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	2.91e-05	3	109	2	18434746
Pubmed	TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer.	ARID1A ARID1B	2.91e-05	3	109	2	34044070
Pubmed	Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes.	ARID1A ARID1B	2.91e-05	3	109	2	26716708
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	2.91e-05	3	109	2	9204703
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	2.91e-05	3	109	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	2.91e-05	3	109	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	2.91e-05	3	109	2	9242641
Pubmed	Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.	ARID1A ARID1B	2.91e-05	3	109	2	22426308
Pubmed	Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.	ARID1A ARID1B	2.91e-05	3	109	2	24382590
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	2.91e-05	3	109	2	25239916
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1E	2.91e-05	3	109	2	24523520
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	2.91e-05	3	109	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	2.91e-05	3	109	2	11159936
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	2.91e-05	3	109	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	2.91e-05	3	109	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	2.91e-05	3	109	2	7635066
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	SLC36A1 ARSK NPAS3 SALL4 GPRIN1 TRUB2 RYR1 RYR3 KCNJ3 FECH CDYL KIF5A	3.10e-05	915	109	12	32393512
Pubmed	ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.	ARID1A IGF1R DHX35 FUBP3	3.64e-05	59	109	4	34108663
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1E WDR33 FAM98A FNBP1L ARID1A EEF2 C9orf43 MDN1 ITSN2 MACF1 KIF5A KIF5C USPL1 FUBP3 XRCC6	4.47e-05	1442	109	15	35575683
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	WDR33 SALL4 ARID1A PPP1R10 EEF2 FUBP3	4.51e-05	203	109	6	22083510
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	RPS2 ANKHD1 PPP1R10 EEF2 MDN1 MACF1 FRMPD3 XRCC6 AHNAK2	5.14e-05	538	109	9	28524877
Pubmed	Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation.	ARID1A ARID1B IGF1R	5.78e-05	24	109	3	37543677
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	5.82e-05	4	109	2	22100703
Pubmed	Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells.	NCOA2 PPARGC1A	5.82e-05	4	109	2	19462000
Pubmed	Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.	NCOA2 PPARGC1A	5.82e-05	4	109	2	17513608
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	5.82e-05	4	109	2	23413940
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1E	5.82e-05	4	109	2	37141091
Interaction	NR3C1 interactions	NCOA2 ROBO4 PON2 ADAM30 BCL9 ARID1A AP3M1 DNAH7 TMEM200A RYR1 PPARGC1A ARID1B MDN1 ITSN2 FECH PCK2 AHNAK2	1.43e-05	974	107	17	int:NR3C1
Interaction	NUP35 interactions	NCOA2 WDR33 PON2 BCL9 ARID1A ANKHD1 ARID1B MCM3AP FUBP3 PCK2 EPB41L2	1.59e-05	424	107	11	int:NUP35
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	4.68e-05	3	72	2	287
GeneFamily	Arachidonate lipoxygenases	ALOX12 ALOX12B	2.32e-04	6	72	2	407
GeneFamily	EF-hand domain containing	CACNA1E DNAH7 RYR3 ITSN2 MACF1 TNNC1	2.37e-04	219	72	6	863
GeneFamily	Classical BAR domain containing	ARHGEF38 DNMBP	4.31e-04	8	72	2	1292
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF9 KIF5A KIF5C	8.13e-04	46	72	3	622
GeneFamily	AT-rich interaction domain containing	ARID1A ARID1B	1.59e-03	15	72	2	418
GeneFamily	Dyneins, axonemal	DNAH3 DNAH7	2.05e-03	17	72	2	536
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF38 ITSN2 DNMBP	2.32e-03	66	72	3	722
GeneFamily	NLR family	NLRP12 NLRC5	4.42e-03	25	72	2	666
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1E	4.78e-03	26	72	2	253
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TMEM200A RYR1 RYR3 KIF9 LIPM ALOX12B AHNAK2	6.74e-08	144	109	7	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	UBTFL1 ZNF521 SALL4 FNBP1L LY6H AADAT MN1	1.85e-07	167	109	7	cb396f3edb9e8fdc316091e8e193dbba50e0be0c
ToppCell	Control-Endothelial-VE_Capillary_B\|Control / Disease state, Lineage and Cell class	ROBO4 SYN3 DACH1 PON2 FNBP1L OSMR ACKR1	4.60e-07	191	109	7	322237793a1278bafb14e63cab688b353e352dcc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A CACNA1E DNAH3 NLRP12 RYR1 MTUS2	3.53e-06	167	109	6	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1A CACNA1E NPAS3 KIF5C LY6H MTUS2	3.53e-06	167	109	6	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA2 CACNA1A SH3BP2 KIF9 DNMBP RUBCN	3.53e-06	167	109	6	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1A CACNA1E NPAS3 KCNJ3 KIF5A KIF5C	3.78e-06	169	109	6	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1A CACNA1E GPRIN1 KIF5C AADAT TNNC1	4.04e-06	171	109	6	dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1E CCDC184 PRMT8 KIF5A KIF5C LY6H	6.35e-06	185	109	6	110d5f02759c8235b14aea524ea47199696094ea
ToppCell	Endothelial-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 DACH1 ZNF521 MSX1 DCHS1 ACKR1	6.55e-06	186	109	6	796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	INO80D PPP1R10 IFRD1 ARID1B MACF1 RAPGEF2	6.96e-06	188	109	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SYN3 PDGFRB DACH1 APBB2 FNBP1L RAPGEF2	7.40e-06	190	109	6	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	IPF-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	ROBO4 DACH1 ZNF521 FNBP1L OSMR ACKR1	8.58e-06	195	109	6	120296531bbc8080dcabacbd64733cc1dc34603a
ToppCell	IPF-Endothelial-VE_Peribronchial\|IPF / Disease state, Lineage and Cell class	ROBO4 DACH1 ZNF521 FNBP1L OSMR ACKR1	8.58e-06	195	109	6	2c3ad3cb79f11119ac69c413a938d21199145040
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 ZNF521 RYR3 DCHS1 OSMR ACKR1	9.63e-06	199	109	6	07bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 APBB2 INO80D ARID1B IGF1R RAPGEF2	9.63e-06	199	109	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	VE-CD4-CD8_1\|VE / Condition, Cell_class and T cell subcluster	PATL2 YARS1 C9orf43 OSMR DNMBP	1.31e-05	123	109	5	bc0f509716bb71d6e3fa343f4920ecb80eb62794
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c10-IFNG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCDC184 SYN3 ARMC2 MOGS FAM167A-AS1	1.47e-05	126	109	5	d19382597ce5c6546731ac1fd33c7dcb7916b2ea
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	ZNF521 FNBP1L LY6H AADAT MN1	3.30e-05	149	109	5	078e1e5765e476ba85c23fb8f6892b6698cbcbdb
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	NLRP12 FREM3 GBA2 RYR3 PPARGC1A	3.86e-05	154	109	5	df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ROBO4 NPAS3 ZNF521 EEF2 C9orf43	4.11e-05	156	109	5	bb2876bdf2375866d7509eba3c48322326349fa8
ToppCell	COVID_non-vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ROBO4 ZNF521 FNBP1L SYTL5 AADAT	4.36e-05	158	109	5	0d4fe87fc7901dd5f9c004e91708a03cafdb4ad9
ToppCell	11.5-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	NLRP12 FECH MROH7 CDYL ACKR1	5.06e-05	163	109	5	e9d814952d824539ff1dea119e4fca14a8c335a8
ToppCell	11.5-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	NLRP12 FECH MROH7 CDYL ACKR1	5.06e-05	163	109	5	31b60e065bac4ad380247964e7574f210106ebae
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A NLRP12 KIF5C FRMPD3 MTUS2	6.35e-05	171	109	5	99176a932569fa1c7e1c01009684f5a65244b96e
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SLC36A1 ARMC2 AP3M2 NLRC5 DNMBP	6.53e-05	172	109	5	d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCell	Endothelial-A-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 DACH1 ZNF521 DCHS1 ACKR1	6.53e-05	172	109	5	a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCell	Tuft-tuft-4\|World / Class top	FNBP1L MDN1 DHX35 USPL1 MN1	6.89e-05	174	109	5	d6f306ebf66061bf9e9742000bfedce12d277452
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A RYR1 KIF5A TNNC1 ACKR1	6.89e-05	174	109	5	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	ROBO4 DACH1 ZNF521 DCHS1 ACKR1	6.89e-05	174	109	5	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	CACNA1A DACH1 NPAS3 GPRIN1 KCNJ3	7.08e-05	175	109	5	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1A DACH1 NPAS3 GPRIN1 KCNJ3	7.08e-05	175	109	5	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	ROBO4 DACH1 ZNF521 DCHS1 ACKR1	7.28e-05	176	109	5	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ROBO4 SYN3 DACH1 MAGEE1 MSX1	7.47e-05	177	109	5	16197068260fc062bf8b730a51a199887ea580b9
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ROBO4 ZNF521 MACF1 SLC24A1 EPB41L2	7.68e-05	178	109	5	ad3de3e03a401dac64431a541899445262246347
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 DACH1 APBB2 GBA2 RUBCN	7.88e-05	179	109	5	dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A GPRIN1 RYR1 KIF5C ACKR1	8.09e-05	180	109	5	6ac62bf1251978c8c12e715f7b73144fca619794
ToppCell	Endothelial-A-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 DACH1 MSX1 DCHS1 ACKR1	8.09e-05	180	109	5	4c3376169770ee9f9283daae44c17f35e46bfd19
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ROBO4 ZNF521 MACF1 SLC24A1 EPB41L2	8.30e-05	181	109	5	e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	CACNA1A SYN3 NPAS3 KCNJ3 KIF5C	8.52e-05	182	109	5	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	ROBO4 DACH1 ZNF521 TMEM200A EPB41L2	8.52e-05	182	109	5	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DACH1 APBB2 PPARGC1A TNNC1 NNT	8.75e-05	183	109	5	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB DACH1 NPAS3 APBB2 RYR3	8.75e-05	183	109	5	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB DACH1 NPAS3 APBB2 RYR3	8.75e-05	183	109	5	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	Endothelial-A-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 DACH1 ZNF521 DCHS1 ACKR1	8.75e-05	183	109	5	2c3f2c25c38f0598b4787d2ec335efe00fdc9751
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB DACH1 NPAS3 APBB2 RYR3	8.97e-05	184	109	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	Endothelial-A-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 DACH1 ZNF521 RYR3 ACKR1	9.20e-05	185	109	5	ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB MSX1 DCHS1 OSMR MN1	9.20e-05	185	109	5	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNJ3 CDYL KIF5A KIF5C ACKR1	9.20e-05	185	109	5	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	PDGFRB DACH1 APBB2 FNBP1L RAPGEF2	9.20e-05	185	109	5	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	Endothelial-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	ROBO4 DACH1 ZNF521 DCHS1 ACKR1	9.20e-05	185	109	5	dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ROBO4 ZNF521 MACF1 SLC24A1 EPB41L2	9.44e-05	186	109	5	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1A SYN3 NPAS3 KCNJ3 KIF5C	9.44e-05	186	109	5	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SYN3 DACH1 ZNF521 OSMR ACKR1	9.68e-05	187	109	5	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KCNJ3 FRMPD3 TNNC1 MTUS2	9.68e-05	187	109	5	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1E NPAS3 KCNJ3 KIF5A KIF5C	9.68e-05	187	109	5	98477ba04a42a8da80a72f41a182429f46283595
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KCNJ3 FRMPD3 TNNC1 MTUS2	9.68e-05	187	109	5	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A KCNJ3 FRMPD3 TNNC1 MTUS2	9.68e-05	187	109	5	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 APBB2 MSX1 RTL8A OSMR	9.93e-05	188	109	5	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1A SYN3 NPAS3 KCNJ3 KIF5C	9.93e-05	188	109	5	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ROBO4 NPAS3 ZNF521 RYR3 ACKR1	1.02e-04	189	109	5	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	LV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	UAP1 PDGFRB ZNF521 KIF5C MN1	1.02e-04	189	109	5	3922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCell	Control-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	ROBO4 DACH1 ZNF521 OSMR ACKR1	1.02e-04	189	109	5	c76d8af2e0aa4a83ee0c3439c894566fbf117dd3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A GPRIN1 KIF5C FRMPD3 ACKR1	1.02e-04	189	109	5	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	UAP1 PDGFRB ZNF521 FRMPD3 MN1	1.04e-04	190	109	5	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	Control-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	ROBO4 SYN3 DACH1 PON2 OSMR	1.07e-04	191	109	5	c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR3 PPARGC1A KCNJ3 TNNC1 MTUS2	1.07e-04	191	109	5	97fb4232417a39801e87725755fd16a57c250209
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR3 PPARGC1A KCNJ3 TNNC1 MTUS2	1.07e-04	191	109	5	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 NPAS3 ZNF521 RYR3 ACKR1	1.10e-04	192	109	5	1ee4783051ec94ea94600f040edcb385fc4289f1
ToppCell	facs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB MOGS SLC16A11 MN1 PCK2	1.10e-04	192	109	5	03dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC184 DACH1 APBB2 FNBP1L RTL8A	1.10e-04	192	109	5	35f7926628a967f85b26371e795a1b93c6f103ab
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DACH1 ARID1B IGF1R MACF1 RAPGEF2	1.10e-04	192	109	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRMT8 GPRIN1 TMEM200A KCNJ3	1.12e-04	193	109	5	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRMT8 GPRIN1 TMEM200A KCNJ3	1.12e-04	193	109	5	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FNBP1L FECH RAPGEF2 ACKR1 MBNL3	1.12e-04	193	109	5	305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GPRIN1 KCNJ3 KIF5C LY6H ACKR1	1.12e-04	193	109	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 MACF1 OSMR ACKR1 EPB41L2	1.12e-04	193	109	5	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 RYR3 DCHS1 OSMR ACKR1	1.12e-04	193	109	5	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CCDC184 PDGFRB ZNF521 OSMR MN1	1.12e-04	193	109	5	194e7fa00a50cc4e026987b715323d125d79594e
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PON2 DNAH7 KIF9 KIF5A LY6H	1.12e-04	193	109	5	c3522693439c23830d8a3f20854539ccb7a666e0
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ROBO4 SYN3 DACH1 PON2 OSMR	1.12e-04	193	109	5	ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FNBP1L FECH RAPGEF2 ACKR1 MBNL3	1.12e-04	193	109	5	dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A GPRIN1 KIF5C FRMPD3 ACKR1	1.12e-04	193	109	5	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	droplet-Lung-30m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC184 DACH1 APBB2 FNBP1L RTL8A	1.15e-04	194	109	5	cf7f232827945fbafd2c298c08a799ab916c2472
ToppCell	LV-14._Fibroblast_III\|LV / Chamber and Cluster_Paper	UAP1 PDGFRB ZNF521 KIF5C MN1	1.15e-04	194	109	5	927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MAGEE1 KIF5A KIF5C HERC2 LY6H	1.15e-04	194	109	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF38 FNBP1L DNAH7 PPARGC1A KCNJ3	1.15e-04	194	109	5	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 APBB2 ZNF521 IGF1R MACF1	1.15e-04	194	109	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF38 FNBP1L DNAH7 PPARGC1A KCNJ3	1.18e-04	195	109	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1A PRMT8 SYN3 KIF5C EPB41L2	1.18e-04	195	109	5	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 APBB2 ARID1B IGF1R RAPGEF2	1.21e-04	196	109	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ROBO4 DACH1 ZNF521 DCHS1 ACKR1	1.21e-04	196	109	5	d5d3028fcbfa251a206d17ec33b3b313968f9d79
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	ROBO4 NPAS3 APBB2 ZNF521 IGF1R	1.21e-04	196	109	5	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH3 FNBP1L DNAH7 MACF1 OSMR	1.21e-04	196	109	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DACH1 APBB2 TMEM200A OSMR EPB41L2	1.21e-04	196	109	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	nucseq-Endothelial-Endothelial_Vascular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ROBO4 SYN3 DACH1 ACKR1 EPB41L2	1.21e-04	196	109	5	686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH3 FNBP1L DNAH7 MACF1 OSMR	1.21e-04	196	109	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 ZNF521 RYR3 OSMR ACKR1	1.24e-04	197	109	5	87eda06344498dc66cac292cf89746dc90b5cf67
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 APBB2 MACF1 OSMR ACKR1	1.24e-04	197	109	5	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC184 PRMT8 KIF5A KIF5C LY6H	1.24e-04	197	109	5	27c044833e471a312a572e0b1c83e4bc8a36e896
Drug	DM-nitrophen	CACNA1A RYR1 RYR3 TNNC1	8.34e-07	16	108	4	CID000003083
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	NCOA2 APBB2 FNBP1L IGF1R MDN1 ITSN2 CDYL RAPGEF2	2.65e-06	183	108	8	7498_DN
Drug	Ketotifen fumarate [34580-14-8]; Down 200; 9.4uM; HL60; HG-U133A	PRPF31 RPS2 MCM3AP ITSN2 AP3M2 MACF1 NNT EPB41L2	4.75e-06	198	108	8	1583_DN
Drug	AC1N9ZZC	CACNA1A RYR1 RYR3 KIF5A NNT ALOX12 ALOX12B	7.16e-06	149	108	7	CID004369374
Drug	CNS 1145	CACNA1A CACNA1E RYR1 RYR3	1.76e-05	33	108	4	CID000190902
Drug	IHC-64	CACNA1A CACNA1E RYR1 RYR3	1.76e-05	33	108	4	CID000162753
Drug	methyl 4-O-feruloyl-5-O-caffeoylquinate	ALOX12 ALOX12B	2.23e-05	2	108	2	CID000637085
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	2.23e-05	2	108	2	ctd:C005147
Drug	AC1LC8RY	ALOX12 ALOX12B	2.23e-05	2	108	2	CID000596379
Drug	AC1NSZ1A	ALOX12 ALOX12B	2.23e-05	2	108	2	CID005320076
Drug	mamegakinone	ALOX12 ALOX12B	2.23e-05	2	108	2	CID000167673
Drug	Oxaloacetic Acid	PPARGC1A PCK2	2.23e-05	2	108	2	ctd:D062907
Drug	tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA	NCOA2 APBB2 ARID1A MDN1 CDYL RAPGEF2 USPL1	2.92e-05	185	108	7	1114_DN
Drug	bepridil	CACNA1A CACNA1E RYR1 RYR3 TNNC1 SLC24A1	3.08e-05	126	108	6	CID000002351
Drug	NP-EGTA	RYR1 RYR3 TNNC1	3.64e-05	14	108	3	CID000183793
Drug	AC1L1IZE	DNAH3 GBA2 RYR1 RYR3 IGF1R KCNJ3	3.83e-05	131	108	6	CID000004799
Drug	Bisoprolol fumarate; Up 200; 9uM; MCF7; HT_HG-U133A	SH3BP2 DACH1 IGF1R KCNJ3 DHX35 OSMR NNT	4.08e-05	195	108	7	5348_UP
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SH3BP2 APBB2 ARID1A CDYL DHX35 SLC24A1 NNT	4.08e-05	195	108	7	4358_DN
Drug	Benzthiazide [91-33-8]; Down 200; 9.2uM; MCF7; HT_HG-U133A	NCOA2 RPS2 SH3BP2 APBB2 MCM3AP OSMR EPB41L2	4.21e-05	196	108	7	3329_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A	NCOA2 SH3BP2 BCL9 ARID1A PLEKHO2 DHX35 OSMR	4.21e-05	196	108	7	2314_DN
Drug	Proguanil hydrochloride [637-32-1]; Up 200; 13.8uM; MCF7; HT_HG-U133A	DACH1 NPAS3 INO80D RYR1 PLEKHO2 MACF1 KIF5C	4.35e-05	197	108	7	5506_UP
Drug	CP-690334-01 [459212-38-5]; Up 200; 1uM; MCF7; HT_HG-U133A	ROBO4 WDR33 DNAH7 IGF1R MN1 ALOX12B AHNAK2	4.49e-05	198	108	7	4383_UP
Drug	8(S),15(S)-diHETE	RYR1 ALOX12 ALOX12B	4.53e-05	15	108	3	CID000001897
Drug	Simvastatin [79902-63-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	WDR33 RPS2 SH3BP2 DACH1 APBB2 PLEKHO2 RAPGEF2	4.79e-05	200	108	7	3340_DN
Drug	capsazepine	CACNA1A CACNA1E SALL4 ALOX12 ALOX12B	5.01e-05	84	108	5	CID002733484
Drug	isodiospyrin	ALOX12 ALOX12B	6.67e-05	3	108	2	CID000099298
Drug	trioxilin B3	ALOX12 ALOX12B	6.67e-05	3	108	2	CID005283210
Drug	12-HPEPE	ALOX12 ALOX12B	6.67e-05	3	108	2	CID006438529
Drug	cis-diammineplatinum(II	RYR1 RYR3	6.67e-05	3	108	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	6.67e-05	3	108	2	CID002750949
Drug	leucothol A	ALOX12 ALOX12B	6.67e-05	3	108	2	CID005491637
Drug	8N3-cADPR	RYR1 RYR3	6.67e-05	3	108	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	6.67e-05	3	108	2	CID009570289
Drug	2-hydroxycarbazole	RYR1 RYR3	6.67e-05	3	108	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	6.67e-05	3	108	2	CID000080262
Drug	flubendiamide	RYR1 RYR3	6.67e-05	3	108	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	6.67e-05	3	108	2	CID005748312
Drug	7-methyljuglone	ALOX12 ALOX12B	6.67e-05	3	108	2	CID000026905
Drug	kazinol B	RYR1 RYR3 ALOX12	6.72e-05	17	108	3	CID000480869
Drug	AC1L380G	RYR1 RYR3 TNNC1	9.52e-05	19	108	3	CID000084698
Drug	tectorigenin	RYR1 IGF1R ALOX12	1.30e-04	21	108	3	CID005281811
Drug	A-30	RYR1 RYR3	1.33e-04	4	108	2	CID003028528
Drug	AC1NR1PE	ALOX12 ALOX12B	1.33e-04	4	108	2	CID005283182
Drug	11,12-leukotriene A4	ALOX12 ALOX12B	1.33e-04	4	108	2	CID006438638
Drug	xanthomicrol	ALOX12 ALOX12B	1.33e-04	4	108	2	CID000073207
Drug	PCB74	RYR1 RYR3	1.33e-04	4	108	2	CID000036218
Drug	C02639	ALOX12 ALOX12B	1.33e-04	4	108	2	CID000439776
Drug	AC 110	CACNA1A CACNA1E	1.33e-04	4	108	2	CID000022860
Drug	148504-47-6	RYR1 RYR3	1.33e-04	4	108	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	1.33e-04	4	108	2	CID009589366
Drug	SC 38249	RYR1 RYR3	1.33e-04	4	108	2	CID000134834
Drug	R 68 151	ALOX12 ALOX12B	1.33e-04	4	108	2	CID000132150
Drug	AC1L4ENC	ALOX12 ALOX12B	1.33e-04	4	108	2	CID000155619
Drug	AC1L1U7A	RYR1 RYR3	1.33e-04	4	108	2	CID000035682
Drug	Cinildipine	CACNA1A CACNA1E RYR1 RYR3	1.45e-04	56	108	4	CID000002752
Drug	gabapentin	CACNA1A CACNA1E SLC36A1 RYR1 RYR3 AADAT	1.57e-04	169	108	6	CID000003446
Drug	S-2-pentyl-4-pentynoic hydroxamic acid	UAP1 WDR33 PON2 SALL4 MAGEE1 ARID1A GPRIN1 ARMC2 TRUB2 RYR1 KIF9 PLEKHO2 AP3M2	1.62e-04	834	108	13	ctd:C513635
Drug	bis(maltolato)oxovanadium(IV	PDGFRB IGF1R PCK2	1.72e-04	23	108	3	CID003035454
Drug	nilvadipine	CACNA1A CACNA1E RYR1 RYR3	1.90e-04	60	108	4	CID000004494
Drug	IAA-94	CACNA1A CACNA1E RYR1 RYR3	2.03e-04	61	108	4	CID000003667
Drug	19-hydroxy-PGB2	ALOX12 ALOX12B	2.21e-04	5	108	2	CID005283111
Drug	14-hydroxydocosahexaenoic acid	ALOX12 ALOX12B	2.21e-04	5	108	2	CID006439735
Drug	AC1Q5RRW	ALOX12 ALOX12B	2.21e-04	5	108	2	CID000039940
Drug	hibifolin	ALOX12 ALOX12B	2.21e-04	5	108	2	CID005490334
Drug	artonin E	ALOX12 ALOX12B	2.21e-04	5	108	2	CID005481962
Drug	6,7,4'-trihydroxyisoflavan	ALOX12 ALOX12B	2.21e-04	5	108	2	CID000125101
Drug	3-quinolinecarbonitrile	PDGFRB IGF1R	2.21e-04	5	108	2	CID000093177
Drug	2-hexadecynoic acid	ALOX12 ALOX12B	2.21e-04	5	108	2	CID000151047
Drug	lercanidipine	CACNA1A CACNA1E RYR1 RYR3	2.30e-04	63	108	4	CID000065866
Disease	neuroblastoma (is_implicated_in)	ARID1A ARID1B IGF1R	5.16e-06	10	105	3	DOID:769 (is_implicated_in)
Disease	Bile Duct Diseases	MAGEE1 FECH	1.25e-05	2	105	2	C0005395
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	3.75e-05	3	105	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	3.75e-05	3	105	2	DOID:8545 (implicated_via_orthology)
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1E	3.75e-05	3	105	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1E	7.49e-05	4	105	2	DOID:6364 (implicated_via_orthology)
Disease	CUB and Sushi domain-containing protein 2 measurement	NLRP12 PLEKHO2	7.49e-05	4	105	2	EFO_0803314
Disease	Malignant neoplasm of breast	NCOA2 ARHGEF38 MRPL13 MAGEE1 ARID1A EEF2 ARID1B IGF1R ITSN2 MROH7 NLRC5 MACF1 HERC2	1.15e-04	1074	105	13	C0006142
Disease	SH3 domain-binding protein 2 measurement	NLRP12 SH3BP2	1.25e-04	5	105	2	EFO_0802063
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	ARID1A ARID1B	1.25e-04	5	105	2	C3281201
Disease	obesity (biomarker_via_orthology)	PON2 PPARGC1A IGF1R NNT ALOX12	1.85e-04	147	105	5	DOID:9970 (biomarker_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	NLRP12 ARID1A RYR1 EEF2 ALOX12B	1.91e-04	148	105	5	C0279702
Disease	amyotrophic lateral sclerosis (is_implicated_in)	PON2 PPARGC1A KIF5A	2.01e-04	32	105	3	DOID:332 (is_implicated_in)
Disease	basophil percentage of granulocytes	NCOA2 SLC36A1 RYR1 ACKR1	2.24e-04	83	105	4	EFO_0007995
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1E	2.60e-04	7	105	2	DOID:0050951 (implicated_via_orthology)
Disease	vascular dementia (is_implicated_in)	PON2 IGF1R	2.60e-04	7	105	2	DOID:8725 (is_implicated_in)
Disease	Neoplasm of uncertain or unknown behavior of breast	ARID1A ARID1B HERC2	4.23e-04	41	105	3	C0496956
Disease	Breast adenocarcinoma	ARID1A ARID1B HERC2	4.23e-04	41	105	3	C0858252
Disease	spinal muscular atrophy (implicated_via_orthology)	KIF5A KIF5C	4.44e-04	9	105	2	DOID:12377 (implicated_via_orthology)
Disease	CXCL1 measurement	PRMT8 ACKR1	4.44e-04	9	105	2	EFO_0010777
Disease	platelet crit	NCOA2 DNAH3 DACH1 ARID1A IGF1R SERINC1 PLEKHO2 DCHS1 MN1 EPB41L2 WDR24	5.86e-04	952	105	11	EFO_0007985
Disease	cryptorchidism (biomarker_via_orthology)	MSX1 IGF1R	6.76e-04	11	105	2	DOID:11383 (biomarker_via_orthology)
Disease	Breast Carcinoma	NCOA2 MRPL13 ARID1A EEF2 ARID1B IGF1R ITSN2 HERC2	6.89e-04	538	105	8	C0678222
Disease	hair colour measurement, hair morphology measurement	MRPL13 HERC2	8.09e-04	12	105	2	EFO_0007821, EFO_0007822
Disease	motor neuron disease (implicated_via_orthology)	KIF5A KIF5C	8.09e-04	12	105	2	DOID:231 (implicated_via_orthology)
Disease	Coffin-Siris syndrome	ARID1A ARID1B	9.54e-04	13	105	2	C0265338
Disease	RAC-beta serine/threonine-protein kinase measurement	NLRP12 SYN3	9.54e-04	13	105	2	EFO_0021989
Disease	Kuhnt-Junius degeneration (is_marker_for)	PDGFRB IGF1R	1.11e-03	14	105	2	DOID:10873 (is_marker_for)
Disease	Sarcomatoid Renal Cell Carcinoma	NLRP12 RYR1 EEF2 ALOX12B	1.15e-03	128	105	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	NLRP12 RYR1 EEF2 ALOX12B	1.15e-03	128	105	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	NLRP12 RYR1 EEF2 ALOX12B	1.15e-03	128	105	4	C1266044
Disease	Papillary Renal Cell Carcinoma	NLRP12 RYR1 EEF2 ALOX12B	1.15e-03	128	105	4	C1306837
Disease	Renal Cell Carcinoma	NLRP12 RYR1 EEF2 ALOX12B	1.15e-03	128	105	4	C0007134
Disease	succinylcarnitine measurement	SYN3 LY6H	1.46e-03	16	105	2	EFO_0020020
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	PON2 PPARGC1A IGF1R	1.63e-03	65	105	3	DOID:0080208 (biomarker_via_orthology)
Disease	response to bronchodilator, FEV/FEC ratio	NCOA2 SYN3 ARHGEF38 FNBP1L TMEM200A MSX1 DHX35 NNT PCK2	1.67e-03	766	105	9	EFO_0004713, GO_0097366
Disease	prostate adenocarcinoma (is_implicated_in)	NCOA2 IGF1R	2.29e-03	20	105	2	DOID:2526 (is_implicated_in)
Disease	prostate cancer (is_marker_for)	NCOA2 EEF2 IGF1R ALOX12	2.38e-03	156	105	4	DOID:10283 (is_marker_for)
Disease	cancer (implicated_via_orthology)	ARID1A YARS1 ARID1B FECH MACF1	2.75e-03	268	105	5	DOID:162 (implicated_via_orthology)
Disease	Lewy Body Disease	PPARGC1A IGF1R	2.77e-03	22	105	2	C0752347
Disease	response to clopidogrel, cardiovascular event measurement	NCOA2 LIPM	3.02e-03	23	105	2	EFO_0006919, GO_1903493
Disease	chronic obstructive pulmonary disease	SYN3 ARHGEF38 NPAS3 BCL9 FREM3 ARMC2 FAM167A-AS1 MN1	3.22e-03	688	105	8	EFO_0000341

Protein segments in the cluster

Peptide	Gene	Start	Entry
KMGNSTDPGPMLAIP	CACNA1A	1096	O00555
VPLLMMGPGIKAGLQ	ARSK	336	Q6UWY0
KSMISLAGGLPNPNM	AADAT	31	Q8N5Z0
GMLPVDKPVGMDILN	APBB2	596	Q92870
EMLTLMSPPLGLGKR	CACNA1E	1766	Q15878
SMGGKTAMLLALQRP	ABHD11	141	Q8NFV4
GKPNLLDMGSLMIKP	ARHGEF38	226	Q9NXL2
MLSPNDKMLGKLDPF	ARMC2	1	Q8NEN0
PMKAIGAQNLLTMPG	SH3BP2	11	P78314
LKKALGMGPGPWMNI	ACKR1	231	Q16570
LEMKPGPQAQGLVME	DNMBP	521	Q6XZF7
VGLADMMSPGESKLP	ARID1B	1081	Q8NFD5
PGRGKMSKLLNPEEM	PRMT8	56	Q9NR22
KLSGMPDLSLSFMNP	AP3M1	211	Q9Y2T2
QMLMGLSPNVLPGPK	DACH1	541	Q9UI36
RSAMLLKPQLGLGAM	MTUS2	761	Q5JR59
ALLPSMVKGLKNMDG	MROH7	1041	Q68CQ1
PSMLGLMTSPENVLK	OSMR	881	Q99650
MHLTDMAKAGQPLPL	ITSN2	306	Q9NZM3
MGMTNLPAVGRKPLD	ARID1A	1036	O14497
KLTGMPDLTLSFMNP	AP3M2	211	P53677
MQKELGIVPSCPGMK	DCHS1	1	Q96JQ0
MMLMSLGGLLGPPLS	SLC16A11	381	Q8NCK7
LNAALATPAKEMGMG	MDN1	4206	Q9NU22
GLEESPNGPKMGLLM	MAGEE1	571	Q9HCI5
KPSSEMGGKMLVPQA	SLC24A1	81	O60721
AKSPGTKFLLLPDMM	LIPM	221	Q5VYY2
LPVSGPELAAMMKIG	HERC2	1856	O95714
LGASGLMLLLPPKMK	MCM3AP	1451	O60318
LDGAPIGVMDQSLMK	EPB41L2	551	O43491
PPSLSKMIQMAGEIA	IGF1R	1106	P08069
CGKTNLAMMRPALPG	PCK2	306	Q16822
MVMIQDGPLPTGADK	FUBP3	196	Q96I24
VIPEDMQMALKPGGS	KIF9	711	Q9HAQ2
LAAPLVMLKMEPNGK	ALOX12	296	P18054
MLPAAMKGLGLALLA	LY6H	1	O94772
PTMGRLQMLGLAGSK	NLRC5	711	Q86WI3
KELMMGVLGPLSIDP	MACF1	4596	Q9UPN3
GMKTRSPKPLLTGLM	MOGS	106	Q13724
KLPMFINSGLAMDGL	PPARGC1A	496	Q9UBK2
SFAPDKPGGILMMDL	PON2	76	Q15165
PGVKAPGMLGMSLAS	PATL2	81	C9JE40
KPMGIPDLGMINDGT	ADAM30	596	Q9UKF2
MGDPGSLQPKLAETM	FNBP1L	441	Q5T0N5
PKIMGGASANEMLLS	CDYL	491	Q9Y232
PMAGLLKFADDLGMG	DNAH3	3531	Q8TD57
TGPMFGPKEAMANLS	GBA2	911	Q9HCG7
RFGMDPKPEMLLGLA	FRMPD3	296	Q5JV73
FPLNPMFAKMLLESG	DHX35	486	Q9H5Z1
LAEKQLGLPPGMAME	BCL9	636	O00512
EMLKLRPGGSDMLPA	BCL9	746	O00512
KAPLTMASPAMLGNV	BCL9	951	O00512
LPGGKQTMLCPEMKI	C9orf43	221	Q8TAL5
MQGMLPAPKPTLGLV	C17orf107	61	Q6ZR85
LSLGQGQGPIAMKML	DNAH7	3461	Q8WXX0
LGPPVMLDAATLKTM	IFRD1	401	O00458
GPEGKMMPIAIQLSQ	ALOX12B	346	O75342
LAMPGAVGPKLMRSD	MBNL3	161	Q9NUK0
MKRLPPASLSPGIAM	FAM167A-AS1	51	Q96KT0
PTLALKMPNGLDGMS	INO80D	116	Q53TQ3
MEGKLHDPQLMGIIP	KIF5A	96	Q12840
AAMGIKSCDPKGPLM	EEF2	381	P13639
KPKTGILMLNMGGPE	FECH	66	P22830
LGKMDPMCSGKPELL	GPRIN1	421	Q7Z2K8
MGLLKQFEGMQLPAA	RUBCN	631	Q92622
MMASLDAPGKVGPAP	SALL4	726	Q9UJQ4
KMLPIGLNMCAPTDQ	RYR1	3516	P21817
LEIMTKDGGDMPAPL	CCDC184	6	Q52MB2
MRLPGAMPALALKGE	PDGFRB	1	P09619
AMSALGEPPILGMNM	MN1	51	Q10571
LKPGPELLAQMSGAM	NNT	666	Q13423
EGPEKFELLLQMPMG	FREM3	2096	P0C091
MDGRVQLMKALLAGP	RTL8A	1	Q9BWD3
KMANNPGTPFEGVLM	SYTL5	706	Q8TDW5
ADLVVSKMSQLPMPG	SYN3	386	O14994
KRVHLMNPMVPGLTG	YARS1	206	P54577
MANPKLLGMGLSEAE	PIH1D1	1	Q9NWS0
LMLNEGKSSGHLMPP	TMEM200A	231	Q86VY9
MEGKLHDPQLMGIIP	KIF5C	96	O60282
MAPAADMTSLPLGVK	MSX1	1	P28360
IALGMSKPPANITMF	FAM98A	151	Q8NCA5
MAEQLGMKLPPGRGL	NPAS3	206	Q8IXF0
MLIPGMEEQLNKIPG	SERINC1	56	Q9NRX5
LIMGGMAQDSPPQIL	ROBO4	21	Q8WZ75
MPEMDLKGPQLDVKG	AHNAK2	2576	Q8IVF2
GSKLGISPLMLAAMN	ANKHD1	1186	Q8IWZ3
GQGVIDKDALGPMML	NCOA2	106	Q15596
VMNPDLTGQTMGKPL	NCOA2	381	Q15596
MKPLAIPANHGVMGQ	RAPGEF2	1	Q9Y4G8
DDPGLMLMGFKPLVL	XRCC6	341	P12956
MMDSPKIGNGLPVIG	USPL1	1	Q5W0Q7
KGKNMAMTGGPDPRL	UBTFL1	306	P0CB47
GIGMVLPLENKMKDP	SLC36A1	271	Q7Z2H8
LKKMLPIGLNMCTPG	RYR3	3371	Q15413
ALLILGEPKEGGMPM	UBE3D	21	Q7Z6J8
SLKMMQAVGGAPARP	ZNF521	616	Q96K83
IMGVAGGLTNLSKMP	PRPF31	231	Q8WWY3
GLLMVGEDMQPKDPA	nan	216	A8MX80
APNGALLMGILGPKM	SLC9B1	481	Q4ZJI4
QGMLPAMSFDGKIIL	UAP1	196	Q16222
LDGKMQPPGKLAAMA	MRPL13	21	Q9BYD1
GLLMVGEDMQPKDPA	nan	186	A8MV72
GLLMVGEDMQPKDPA	nan	216	Q8N9G6
GLLMVGEDMQPKDPA	nan	216	A8MUI8
LKASMGEMQASGPPA	PLEKHO2	321	Q8TD55
GLIRPMNKSPMLITG	TRUB2	196	O95900
LMNSFNLKDMAPGLG	WDR24	481	Q96S15
IPGMGIPEQLKLAME	WDR33	441	Q9C0J8
MPRIKALMTGSLPGF	PIGG	116	Q5H8A4
SAPVPKKLLMMAGID	RPS2	206	P15880
LGKVMRMLGQNPTPE	TNNC1	41	P63316
GSKLPPVLANLMGSM	PPP1R10	551	Q96QC0
IFKTLALSPGAPDMM	TMEM239	31	Q8WW34
STTMGKLMPNLLPAG	TBRG1	276	Q3YBR2
PPKLQKMAGGAARME	KCNJ3	471	P48549
GSMEKAGPLEMAQLL	NLRP12	46	P59046