Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA helicase activity

DHX36 ERCC6 ZGRF1 CHD8

7.01e-0562714GO:0003678
GeneOntologyMolecularFunctionzinc ion binding

KAT7 TRIM11 USP22 AKAP8 HDAC4 ABCC8 ZGRF1 TLL2 TRIM17 TRIM31 ZFYVE1

2.90e-048917111GO:0008270
GeneOntologyMolecularFunctionflavin adenine dinucleotide binding

FMO4 NOS2 GSR PRODH

3.52e-0494714GO:0050660
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

KARS1 FARS2 HARS1

4.48e-0442713GO:0016875
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

KARS1 FARS2 HARS1

4.48e-0442713GO:0004812
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC8 ABCB11 ABCG5

7.06e-0449713GO:0140359
GeneOntologyMolecularFunctiontransition metal ion binding

KAT7 TRIM11 USP22 AKAP8 HDAC4 ABCC8 ZGRF1 TLL2 TRIM17 TRIM31 XPNPEP1 ZFYVE1

9.19e-0411897112GO:0046914
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

DHX36 ERCC6 ZGRF1 CHD8

1.09e-03127714GO:0008094
Domainaa-tRNA-synth_II

KARS1 FARS2 HARS1

4.12e-0518713IPR006195
DomainAA_TRNA_LIGASE_II

KARS1 FARS2 HARS1

4.12e-0518713PS50862
DomainABC_tran

ABCC8 ABCB11 ABCG5

8.05e-0448713PF00005
DomainABC_TRANSPORTER_2

ABCC8 ABCB11 ABCG5

8.05e-0448713PS50893
DomainABC_TRANSPORTER_1

ABCC8 ABCB11 ABCG5

8.56e-0449713PS00211
DomainABC_transporter-like

ABCC8 ABCB11 ABCG5

9.08e-0450713IPR003439
DomaintRNA_anti-codon

KARS1 NABP2

9.18e-0412712PF01336
DomainNA-bd_OB_tRNA

KARS1 NABP2

9.18e-0412712IPR004365
Domain-

FMO4 CHM GSR

1.26e-03567133.50.50.60
DomainFAD/NAD-binding_dom

FMO4 CHM GSR

1.33e-0357713IPR023753
Domain-

TRIM11 USP22 TRIM17 TRIM31 ZNF521 ZFYVE1 PHF13

1.57e-034497173.30.40.10
DomainZnf_RING/FYVE/PHD

TRIM11 USP22 TRIM17 TRIM31 ZNF521 ZFYVE1 PHF13

1.77e-03459717IPR013083
DomainBBOX

TRIM11 TRIM17 TRIM31

2.30e-0369713SM00336
Domain-

TRIM11 TRIM17 TRIM31

2.50e-03717134.10.45.10
Domainzf-B_box

TRIM11 TRIM17 TRIM31

2.60e-0372713PF00643
DomainZF_BBOX

TRIM11 TRIM17 TRIM31

3.51e-0380713PS50119
DomainZnf_B-box

TRIM11 TRIM17 TRIM31

3.63e-0381713IPR000315
DomainABC_membrane

ABCC8 ABCB11

3.73e-0324712PF00664
PathwayWP_CILIOPATHIES

AHI1 CEP120 PKD1L1 IFT122 RP1 DNAAF11

5.64e-05184526M39880
Pubmed

Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice.

PRKDC NOS2

4.11e-06271211426950
Pubmed

Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.

PRKDC NOS2

4.11e-06271217982083
Pubmed

Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription.

DHX36 HDAC4

4.11e-06271221590736
Pubmed

Molecular and computational characterization of ABCB11 and ABCG5 variants in Tunisian patients with neonatal/infantile low-GGT intrahepatic cholestasis: Genetic diagnosis and genotype-phenotype correlation assessment.

ABCB11 ABCG5

4.11e-06271238108658
Pubmed

Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.

HDAC4 ELSPBP1

1.23e-05371219950203
Pubmed

A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.

ABCB11 ABCG5

1.23e-05371215040800
Pubmed

Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.

PRKDC NOS2

1.23e-05371221576322
Pubmed

Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.

PRKDC NOS2

1.23e-05371221576342
Pubmed

Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.

PRKDC PHF13

1.23e-05371224794298
Pubmed

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

TRIM11 TRIM17 TRIM31

2.30e-052771321143188
Pubmed

Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.

KAT7 PRKDC

2.46e-05471239321266
Pubmed

A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.

PRKDC NOS2

2.46e-05471210878373
Pubmed

Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice.

PRKDC NOS2

2.46e-05471216365445
Pubmed

G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease.

PRKDC NOS2

2.46e-05471225834108
Pubmed

A role for the HOXB7 homeodomain protein in DNA repair.

HOXB7 PRKDC

4.09e-05571217308091
Pubmed

Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.

ABCB11 PRKDC

4.09e-05571219833092
Pubmed

Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.

PRKDC NOS2

4.09e-0557129144497
Pubmed

Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.

PRKDC NOS2

4.09e-05571210950807
Pubmed

Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility.

CR1 NOS2

4.09e-05571217709521
Pubmed

Analysis of DNA methylation and histone modification profiles of liver-specific transporters.

ABCB11 ABCG5

6.13e-05671219047482
Pubmed

Exome sequencing of index patients with retinal dystrophies as a tool for molecular diagnosis.

RP1 CHM

6.13e-05671223940504
Pubmed

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.

PRKDC NOS2

6.13e-05671227622331
Pubmed

The tripartite motif family identifies cell compartments.

TRIM11 TRIM17 TRIM31

8.22e-054171311331580
Pubmed

Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice.

LIPH NOS2

8.57e-05771216254318
Pubmed

Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.

VWF SPRED1

1.14e-04871217438136
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

AHI1 ERCC6 RP1 CHM ARSG

1.17e-0423371532290105
Pubmed

Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.

PRKDC NOS2

1.47e-04971216239576
Pubmed

Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut.

PHOX2A NOS2

1.83e-041071210536054
Pubmed

Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.

AHI1 RP1

1.83e-041071220592197
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MED20 KAT7 TRIM11 KARS1 USP22 GBE1 CHD8 PRKDC NUP205

2.17e-04101471932416067
Pubmed

Candidate-gene testing for orphan limb-girdle muscular dystrophies.

TRIM11 TRIM17

2.23e-041171219472918
Pubmed

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.

USP22 PRKDC

2.23e-041171235449157
Pubmed

Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.

PRKDC NOS2

2.23e-041171228973896
Pubmed

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.

AHI1 RP1

2.23e-041171229899041
Pubmed

A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.

HOXB7 VWF

2.68e-04127128986815
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DCHS2 VWF CNST NABP2 USP32 ZNF521 SPRED1 IFT122 PRKDC HARS1

2.72e-041285711035914814
Pubmed

Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.

TRIM17 USP32 TRIM31

2.97e-046371323105109
Pubmed

Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.

KARS1 HARS1

3.16e-041371211829477
Pubmed

Identification of potential protein interactors of Lrrk2.

AKAP8 PRKDC

4.24e-041571217400507
Pubmed

Functional analysis of candidate genes from genome-wide association studies of hearing.

DIPK1A ARSG

5.48e-041771231927188
Pubmed

Docking motif-guided mapping of the interactome of protein phosphatase-1.

CNST SPRED1 ZFYVE1

5.98e-048071319389623
Pubmed

Human and mouse proteases: a comparative genomic approach.

MED20 USP22 USP32

6.21e-048171312838346
Pubmed

Tagging genes with cassette-exchange sites.

KAT7 HDAC4 NTNG1 CHD8 CHM

6.23e-0433571515741177
Pubmed

Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

CR1 NOS2

6.87e-041971220459687
Pubmed

Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.

XPNPEP1 NOS2

6.87e-041971221052031
Pubmed

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ATXN7L2 ZNF521 IFT122

7.14e-048571315449545
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

AHI1 KARS1 ERCC6 HDAC4 KRI1

8.39e-0435871532460013
Pubmed

The Exonuclease Trex2 Shapes Psoriatic Phenotype.

ERCC6 NOS2

8.41e-042171227365293
Pubmed

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

TRIM11 TRIM31

8.41e-042171218248090
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DHX36 KARS1 ERCC6 AKAP8 KRI1 PRKDC NUP205

9.09e-0475971735915203
Pubmed

Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.

HOXB7 EDDM3B

9.24e-042271228215940
Pubmed

Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.

ABCC8 ABCB11

1.01e-032371210708515
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

AHI1 AKAP8 IFT122 PRKDC SVOPL NUP205

1.04e-0356471621565611
Pubmed

Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.

AHI1 PRODH

1.10e-032471221821099
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TLL2 NTNG1 ARSG

1.21e-0310271310231032
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

TRIM11 TRIM17 TRIM31

1.32e-0310571322493164
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

KAT7 DHX36 ERCC6 AKAP8 KRI1 PLEKHS1 PRKDC

1.71e-0384771735850772
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MED20 KARS1 USP22 HDAC4 GBE1 CHD8 PRKDC ZNF121

1.81e-03110371834189442
Pubmed

Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.

ERCC6 PRKDC

1.84e-033171220813000
GeneFamilyAminoacyl tRNA synthetases, Class II

KARS1 FARS2 HARS1

1.98e-0519513132
CoexpressionDESCARTES_FETAL_HEART_MEGAKARYOCYTES

CNST LIPH PAQR5 ABCB11 FERMT3

1.30e-05111715M40191
CoexpressionGSE23321_CD8_STEM_CELL_MEMORY_VS_CENTRAL_MEMORY_CD8_TCELL_DN

MED20 KAT7 TRIM11 CHM GSR NAA16

1.55e-05196716M8438
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

HOXB7 FARS2 ZGRF1 GBE1 ZNF121 NUP205

7.83e-07199716fd75dccb37d96448edf72b7d042b06833d4ead24
DrugGlyburide

ABCC8 ABCB11 NOS2 ABCG5 GSR

1.03e-0658715ctd:D005905
Diseaseneural cell adhesion molecule 2 measurement

PHOX2A PGAP6

1.61e-053692EFO_0801827
Diseasebipolar disorder, cytomegalovirus seropositivity

ROR2 ARSG

3.22e-054692EFO_0007037, MONDO_0004985
DiseaseJoubert syndrome with ocular defect

AHI1 CEP120

5.36e-055692C4274118
Diseaseobesity (is_marker_for)

AHI1 VWF HDAC4 NOS2

9.42e-05101694DOID:9970 (is_marker_for)
DiseaseUsher Syndrome, Type III

HARS1 ARSG

1.12e-047692C1568248
Diseasefactor VII activating protease measurement

USP32 PLEKHS1 ZNF121

2.94e-0455693EFO_0009368
DiseaseMental Retardation, Psychosocial

SNX14 AHI1 HDAC4 CHD8

3.22e-04139694C0025363
DiseaseProfound Mental Retardation

SNX14 AHI1 HDAC4 CHD8

3.22e-04139694C0020796
DiseaseMental deficiency

SNX14 AHI1 HDAC4 CHD8

3.22e-04139694C0917816
Diseaseprotein-glutamine gamma-glutamyltransferase e measurement

ABCB11 RP1 ZFYVE1

3.81e-0460693EFO_0020690
Diseasephosphatidylcholine measurement

CEP120 ABCC8 ZGRF1 OR10V1 PLPP4

5.42e-04284695EFO_0010226
Disease

CR1 NOS2

6.33e-0416692611162
DiseaseBlood Platelet Disorders

ABCG5 FERMT3

6.33e-0416692C0005818
DiseaseMalaria, susceptibility to

CR1 NOS2

6.33e-0416692cv:C1970028
DiseaseMalaria

CR1 NOS2

9.96e-0420692C0024530
DiseaseHematochezia, response to radiation

PLPP4 GSR

9.96e-0420692GO_0009314, HP_0002573
DiseaseJoubert syndrome 1

AHI1 CEP120

1.10e-0321692C4551568
Diseasemiddle cerebral artery infarction (biomarker_via_orthology)

ERCC6 HDAC4 NOS2

1.37e-0393693DOID:3525 (biomarker_via_orthology)
Diseasemalaria (is_implicated_in)

CR1 NOS2

1.44e-0324692DOID:12365 (is_implicated_in)
DiseaseDisorder of eye

AHI1 RP1 HARS1 CHM

1.55e-03212694C0015397
DiseaseRetinitis Pigmentosa

AHI1 RP1 CHM

1.88e-03104693C0035334
Diseasebreast milk measurement

FARS2 OR10V1 TRIM31

1.99e-03106693EFO_0009092
Diseasepulmonary hypertension (is_implicated_in)

VWF NOS2

2.25e-0330692DOID:6432 (is_implicated_in)
DiseaseFamilial aplasia of the vermis

AHI1 CEP120

2.25e-0330692C0431399

Protein segments in the cluster

PeptideGeneStartEntry
NYIEFHCSMDGYVDS

EDDM3B

121

P56851
STFGVEYDPDTMQFH

CHD8

1811

Q9HCK8
RDISYHPFENMVAFC

AHI1

891

Q8N157
HMASYGPEPCTDNSD

AKAP8

76

O43823
EFMHDHADYGFPSCE

GSR

121

P00390
FYDPCEGMVTVDGHD

ABCB11

471

O95342
YFGIPYSHDMGCTDT

ARSG

156

Q96EG1
MGNEASYPAEMCSHF

PPP3R2

1

Q96LZ3
SYPAEMCSHFDNDEI

PPP3R2

6

Q96LZ3
MSIFGHCPAHDDFYL

ATXN7L2

66

Q5T6C5
HFLVEDSYFPENMCS

CHM

431

P24386
GPAEAHYAFMLDSCF

NUP205

1361

Q92621
AYTFPDALMCTTFHD

PAQR5

136

Q9NXK6
SFDEFMVPYFGRHGC

ERCC6

736

P0DP91
LGSSMYPRFCAFAHD

NOS2

626

P35228
HNDEIYHFYCDMPAV

OR10V1

171

Q8NGI7
FLFYVMTEADNTGCH

KAT7

441

O95251
GHHAEESTPMGFCYF

HDAC4

801

P56524
MCPSCFQMFHSEDYE

IFT122

1206

Q9HBG6
CMAHYESGFDTAFVD

SPACA5

51

Q96QH8
FEITDDQFDFHTYCM

NAA16

516

Q6N069
MSCYSDFPFHEDYPN

FMO4

66

P31512
HCEDPNFNMDADYDP

KRI1

446

Q8N9T8
AFFDTAEESPFCMYH

LIPH

316

Q8WWY8
MFFSTFYHACDQPGE

PGAP6

581

Q9HCN3
DFFYRCFPDGVMNSE

PLPP4

111

Q5VZY2
PCFLTHGMSYDHDLF

DCHS2

2811

Q6V1P9
AGYGLEPSSFNMHCA

HOXB7

76

P09629
NMFDGTDSCYFHSGP

GBE1

301

Q04446
ASCSPYFHAMFTNEM

KLHL17

111

Q6TDP4
YACDTHPDRGMTFNL

CR1

1801

P17927
HRPCAEDYFNFMGHF

EFCAB6

921

Q5THR3
PQSYCAFDFATMPHQ

CEP120

506

Q8N960
AEKFSEYFGNCPMIH

DHX36

371

Q9H2U1
CAASEFASVDHYPMF

CALHM4

131

Q5JW98
CPEHSNPFDFYMDLT

ABCG5

291

Q9H222
MGNPCASFDHYREFV

DNAAF11

121

Q86X45
SSGGMHEECVFPFTY

ELSPBP1

21

Q96BH3
DVFHGPYGNFLMCDT

DIPK1A

281

Q5T7M9
FYQCDFDIAGNFDPM

HARS1

171

P12081
VFSVFCMSGKPDFHY

PKD1L1

1211

Q8TDX9
CMSGKPDFHYEFSYQ

PKD1L1

1216

Q8TDX9
YCTFGDMESPVCTDF

CNST

686

Q6PJW8
MHNSEYPLSCFALFE

MED20

66

Q9H944
CNYFNMPHGSDSEPF

RP1

1816

P56715
QYYATDCLDAFHMDP

NTNG1

176

Q9Y2I2
PRHQEMFHYFCEDDG

TRIM31

96

Q9BZY9
HNPEFTTCEFYMAYA

KARS1

331

Q15046
MTFYGHFVAGEDQES

PRODH

111

O43272
DQPLSMIFSYCSHGD

ROR2

546

Q01974
DSGESQSPCYCHMFA

SVOPL

326

Q8N434
MPLAFCGSENHSAAY

ABCC8

1

Q09428
CHYEPMESSFFKETS

PLEKHS1

246

Q5SXH7
MDSDSCAAAFHPEEY

PHF13

1

Q86YI8
VCEMSSLFQEFYSGH

USP22

221

Q9UPT9
DYFTDPVMTDCGHNF

TRIM11

21

Q96F44
MHFGTPTAYEKECFT

XPNPEP1

431

Q9NQW7
FQPEDIFSDHHTMCY

VWF

716

P04275
ENVFTPMFCHSDEYF

SNX14

451

Q9Y5W7
LYHCMSDSEGDFSDP

SPRED1

376

Q7Z699
MEASAYGDFGACSQP

PHOX2A

16

O14813
PHCYMGFLTDSSLEE

ZNF521

516

Q96K83
GEFCMVYSEVPNFSE

NABP2

96

Q9BQ15
HQECAYDHLEMYDGP

TLL2

826

Q9Y6L7
MPAHFSDSAQTEACY

FERMT3

181

Q86UX7
MFEHPLSECEFQEYT

PRKDC

2576

P78527
MAHSSFFPDEYFTCS

ZFYVE1

416

Q9HBF4
DYFTDPVMTTCGHNF

TRIM17

21

Q9Y577
ICSSVDMHFDPGFEE

ZNF786

81

Q8N393
CDEYGENFPMLHNSA

ZNF121

41

P58317
GCSQFPDSTEYENFM

ZGRF1

961

Q86YA3
CYFPFTHPSFEMEIN

FARS2

266

O95363
HAQDCDDSMGYQYPF

USP32

1141

Q8NFA0