Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH5 DNAH8 DYNC1H1	4.15e-05	18	76	3	GO:0008569
GeneOntologyMolecularFunction	adenosine-phosphate deaminase activity	AMPD2 AMPD3	4.28e-05	3	76	2	GO:0047623
GeneOntologyMolecularFunction	AMP deaminase activity	AMPD2 AMPD3	4.28e-05	3	76	2	GO:0003876
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	1.42e-04	5	76	2	GO:0140444
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH5 DNAH8 DYNC1H1	1.62e-04	28	76	3	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH5 DNAH8 DYNC1H1	3.75e-04	37	76	3	GO:0045505
GeneOntologyMolecularFunction	DNA topoisomerase activity	TOP1MT TOP2B	3.94e-04	8	76	2	GO:0003916
GeneOntologyMolecularFunction	protein-membrane adaptor activity	JUP SYNE1 SYNE2	6.70e-04	45	76	3	GO:0043495
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH5 DNAH8 DYNC1H1	2.21e-07	14	74	4	IPR011704
Domain	AAA_5	MDN1 DNAH5 DNAH8 DYNC1H1	2.21e-07	14	74	4	PF07728
Domain	DHC_N1	DNAH5 DNAH8 DYNC1H1	3.30e-06	8	74	3	PF08385
Domain	Dynein_heavy_dom-1	DNAH5 DNAH8 DYNC1H1	3.30e-06	8	74	3	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH8 DYNC1H1	2.11e-05	14	74	3	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH8 DYNC1H1	2.11e-05	14	74	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH8 DYNC1H1	2.11e-05	14	74	3	IPR013602
Domain	DHC_N2	DNAH5 DNAH8 DYNC1H1	2.11e-05	14	74	3	PF08393
Domain	MT	DNAH5 DNAH8 DYNC1H1	2.11e-05	14	74	3	PF12777
Domain	AAA_8	DNAH5 DNAH8 DYNC1H1	2.11e-05	14	74	3	PF12780
Domain	DHC_fam	DNAH5 DNAH8 DYNC1H1	2.63e-05	15	74	3	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH8 DYNC1H1	2.63e-05	15	74	3	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH8 DYNC1H1	2.63e-05	15	74	3	PF03028
Domain	AMPD	AMPD2 AMPD3	4.63e-05	3	74	2	IPR006329
Domain	ARM-type_fold	JUP IPO9 UTP20 PUM3 BTAF1 HUWE1 HEATR5B RALGAPA2	5.77e-05	339	74	8	IPR016024
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	9.24e-05	4	74	2	IPR011234
Domain	KASH	SYNE1 SYNE2	9.24e-05	4	74	2	PF10541
Domain	KASH	SYNE1 SYNE2	9.24e-05	4	74	2	IPR012315
Domain	FAA_hydrolase	FAHD2B FAHD2A	9.24e-05	4	74	2	PF01557
Domain	-	FAHD2B FAHD2A	9.24e-05	4	74	2	3.90.850.10
Domain	KASH	SYNE1 SYNE2	9.24e-05	4	74	2	PS51049
Domain	A/AMP_deam_AS	AMPD2 AMPD3	9.24e-05	4	74	2	IPR006650
Domain	KASH	SYNE1 SYNE2	9.24e-05	4	74	2	SM01249
Domain	ARM-like	JUP IPO9 UTP20 PUM3 BTAF1 HUWE1 HEATR5B	9.62e-05	270	74	7	IPR011989
Domain	Spectrin_repeat	SYNE1 SYNE2 MCF2	2.03e-04	29	74	3	IPR002017
Domain	A_deaminase	AMPD2 AMPD3	2.30e-04	6	74	2	PF00962
Domain	A_DEAMINASE	AMPD2 AMPD3	2.30e-04	6	74	2	PS00485
Domain	A/AMP_deaminase_dom	AMPD2 AMPD3	2.30e-04	6	74	2	IPR001365
Domain	-	JUP IPO9 UTP20 PUM3 BTAF1 HEATR5B	2.49e-04	222	74	6	1.25.10.10
Domain	Spectrin/alpha-actinin	SYNE1 SYNE2 MCF2	2.73e-04	32	74	3	IPR018159
Domain	SPEC	SYNE1 SYNE2 MCF2	2.73e-04	32	74	3	SM00150
Domain	HEAT	JUP UTP20 BTAF1	9.09e-04	48	74	3	PF02985
Domain	GrpE_coiled_coil	DNAH8 CNGA1	9.96e-04	12	74	2	IPR013805
Domain	HEAT	JUP UTP20 BTAF1	1.58e-03	58	74	3	IPR000357
Domain	TPR	TRANK1 SUGT1 CABIN1 FKBP5	1.72e-03	129	74	4	SM00028
Domain	TPR_repeat	TRANK1 SUGT1 CABIN1 FKBP5	1.92e-03	133	74	4	IPR019734
Domain	HATPase_c	PDK4 TOP2B	2.27e-03	18	74	2	SM00387
Domain	HATPase_c	PDK4 TOP2B	2.54e-03	19	74	2	PF02518
Domain	AAA+_ATPase	MDN1 DNAH5 DNAH8 DYNC1H1	2.57e-03	144	74	4	IPR003593
Domain	AAA	MDN1 DNAH5 DNAH8 DYNC1H1	2.57e-03	144	74	4	SM00382
Domain	-	TRANK1 MDN1 BTAF1 GFM1 DNAH5 DNAH8 HYDIN DYNC1H1 RAB41	2.67e-03	746	74	9	3.40.50.300
Domain	HEAT_REPEAT	UTP20 BTAF1 HEATR5B	2.70e-03	70	74	3	PS50077
Domain	-	PDK4 TOP2B	2.81e-03	20	74	2	3.30.565.10
Domain	TPR-contain_dom	TRANK1 SUGT1 CABIN1 FKBP5	2.97e-03	150	74	4	IPR013026
Domain	-	GFM1 TOP2B	3.10e-03	21	74	2	3.30.230.10
Domain	HATPase_C	PDK4 TOP2B	3.10e-03	21	74	2	IPR003594
Domain	Ribosomal_S5_D2-typ_fold_subgr	GFM1 TOP2B	3.40e-03	22	74	2	IPR014721
Domain	Actinin_actin-bd_CS	SYNE1 SYNE2	3.71e-03	23	74	2	IPR001589
Domain	Spectrin	SYNE1 SYNE2	3.71e-03	23	74	2	PF00435
Domain	ACTININ_2	SYNE1 SYNE2	3.71e-03	23	74	2	PS00020
Domain	ACTININ_1	SYNE1 SYNE2	3.71e-03	23	74	2	PS00019
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KNTC1 JUP IPO9 MDN1 SYNE1 PCLO SGO2 UTP20 PUM3 HUWE1 CMYA5 PRPF8 GFM1 DNAH5 CNOT1 NEK9 DYNC1H1 TOP2B CDC45	2.59e-10	1425	78	19	30948266
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NBAS SUGT1 UTP20 PUM3 HUWE1 PRPF8 DNAH5 DNAH8 CNOT1 FKBP5 DYNC1H1 TOP2B EXOC4	5.66e-09	704	78	13	29955894
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	KNTC1 NBAS IPO9 MDN1 SUGT1 METTL9 SYNE2 PUM3 BTAF1 HUWE1 PRPF8 CABIN1 CNOT1 FKBP5 DYNC1H1 TOP2B EXOC4	1.61e-08	1440	78	17	30833792
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	JUP MDN1 GLE1 SYNE1 SYNE2 UTP20 PUM3 BTAF1 HUWE1 HEATR5B PRPF8 CNOT1 DYNC1H1 TOP2B	5.98e-08	1024	78	14	24711643
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	JUP LOXHD1 MDN1 SYDE2 PCLO SCN8A UTP20 HUWE1 PRPF8 CNOT1 DYNC1H1 DSE	8.95e-08	736	78	12	29676528
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF609 TRANK1 MDN1 HUWE1 CABIN1 DYNC1H1	1.33e-07	104	78	6	9205841
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	KNTC1 NBAS UTP20 BTAF1 PRPF8 CNOT1 TOP2B	3.74e-07	202	78	7	33005030
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MDN1 GLE1 UTP20 PUM3 PRPF8 RFX1 DYNC1H1 TOP2B	9.94e-07	340	78	8	29478914
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	GLE1 SYNE2 PUM3 HUWE1 PRPF8 CNOT1 DYNC1H1 TOP2B	1.46e-06	358	78	8	32460013
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 JUP IPO9 MDN1 SUGT1 UTP20 PUM3 HUWE1 PRPF8 NEK9 DYNC1H1 TOP2B EXOC4 CDC45	1.70e-06	1353	78	14	29467282
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	MET DNAH5 DNAH8 DYNC1H1	3.88e-06	47	78	4	8812413
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DNAH8 DYNC1H1	3.88e-06	14	78	3	9373155
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	JUP ZNF609 HUWE1 RFX1 CNOT1 NEK9 KAT14 EXOC4	4.58e-06	418	78	8	34709266
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	4.97e-06	2	78	2	22768332
Pubmed	AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.	AMPD2 AMPD3	4.97e-06	2	78	2	23911318
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	4.97e-06	2	78	2	15774318
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	4.97e-06	2	78	2	11792814
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	4.97e-06	2	78	2	24931616
Pubmed	Amplification and expression of c-MET correlate with poor prognosis of patients with gastric cancer and upregulate the expression of PDL1.	MET CD274	4.97e-06	2	78	2	33693450
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	4.97e-06	2	78	2	17267447
Pubmed	Elucidation of the relationships of MET protein expression and gene copy number status with PD-L1 expression and the immune microenvironment in non-small cell lung cancer.	MET CD274	4.97e-06	2	78	2	31931443
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	4.97e-06	2	78	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	4.97e-06	2	78	2	24586179
Pubmed	c-Met and PD-L1 on Circulating Exosomes as Diagnostic and Prognostic Markers for Pancreatic Cancer.	MET CD274	4.97e-06	2	78	2	31284422
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	4.97e-06	2	78	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	4.97e-06	2	78	2	31578382
Pubmed	AMP deaminase 3 plays a critical role in remote reperfusion lung injury.	AMPD2 AMPD3	4.97e-06	2	78	2	23542464
Pubmed	Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma.	MET CD274	4.97e-06	2	78	2	27729745
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	IPO9 MDN1 SUGT1 BTAF1 HUWE1 PRPF8 CNOT1 DYNC1H1 EXOC4	6.33e-06	582	78	9	20467437
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	KNTC1 NBAS ZNF609 SUGT1 SYNE1 SGO2 PRPF8 CNOT1 NEK9 DYNC1H1 TOP2B EXOC4	9.79e-06	1155	78	12	20360068
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	GLE1 SYNE1 UTP20 PUM3 HUWE1 CNOT1 TOP2B	1.00e-05	332	78	7	25693804
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	MDN1 PRPF8 RFX1 CNOT1 TOP2B	1.10e-05	129	78	5	23022380
Pubmed	A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.	SUGT1 PRPF8 FKBP5 DYNC1H1	1.11e-05	61	78	4	19875381
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NBAS MDN1 SYNE1 PCLO SCN8A HUWE1 PRPF8 CNOT1 HYDIN DYNC1H1	1.30e-05	807	78	10	30575818
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	IPO9 MDN1 HUWE1 PRPF8 CNOT1 NEK9 DYNC1H1 TOP2B EXOC4	1.32e-05	638	78	9	33239621
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	IPO9 SUGT1 SGO2 PUM3 HUWE1 CABIN1 CNOT1 NEK9 EXOC4	1.43e-05	645	78	9	25281560
Pubmed	Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression.	MET CD274	1.49e-05	3	78	2	25645920
Pubmed	Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons.	AMPD2 AMPD3	1.49e-05	3	78	2	1400401
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	1.49e-05	3	78	2	10878022
Pubmed	Platelet AMP deaminase. Purification and kinetic studies.	AMPD2 AMPD3	1.49e-05	3	78	2	7287721
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	1.49e-05	3	78	2	16079285
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	1.49e-05	3	78	2	12408964
Pubmed	Low co-expression of PD-L1 and oncogenic receptor tyrosine kinases HER2 and cMET in urothelial carcinoma is associated with discordant expression between primary and metastatic sites.	MET CD274	1.49e-05	3	78	2	37295980
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	1.49e-05	3	78	2	38287013
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	1.49e-05	3	78	2	17462627
Pubmed	Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms.	AMPD2 AMPD3	1.49e-05	3	78	2	9857047
Pubmed	Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA.	AMPD2 AMPD3	1.49e-05	3	78	2	1429593
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	1.49e-05	3	78	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	1.49e-05	3	78	2	25516977
Pubmed	MET-Oncogenic and JAK2-Inactivating Alterations Are Independent Factors That Affect Regulation of PD-L1 Expression in Lung Cancer.	MET CD274	1.49e-05	3	78	2	29898990
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	AMPD3 FAHD2B MDN1 GLE1 FAHD2A SGO2 CDH19 MAPK10 GFM1 NEK9 KAT14 UEVLD	2.01e-05	1242	78	12	30973865
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MET NBAS JUP MDN1 SUGT1 SYNE1 PIEZO1 SYNE2 PRPF8 DEPDC1B FKBP5 TOP2B EXOC4	2.50e-05	1487	78	13	33957083
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MDN1 HUWE1 NEK9 DYNC1H1	2.66e-05	76	78	4	27542412
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	KNTC1 MET JUP LOXHD1 IPO9 SGO2 CMYA5 PRPF8 CNOT1 NEK9 DYNC1H1 EXOC4	2.79e-05	1284	78	12	17353931
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	2.97e-05	4	78	2	16648470
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2	2.97e-05	4	78	2	23071752
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2	2.97e-05	4	78	2	20108321
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	2.97e-05	4	78	2	19596800
Pubmed	Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.	DNAH8 DYNC1H1	2.97e-05	4	78	2	15762842
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2	2.97e-05	4	78	2	28716842
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	JUP SUGT1 HUWE1 RFX1 CNOT1 NEK9 DYNC1H1 EXOC4	3.26e-05	549	78	8	38280479
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	IPO9 PRPF8 RFX1 GFM1 CNOT1 DYNC1H1 EXOC4 CDC45	3.75e-05	560	78	8	35241646
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	KNTC1 NBAS ZNF609 SUGT1 GLE1 TP53I11 HUWE1 GFM1 FKBP5	3.90e-05	733	78	9	34672954
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	JUP HUWE1 PRPF8 DYNC1H1	3.94e-05	84	78	4	29563501
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	MDN1 SYNE2 HUWE1 HYDIN UEVLD	4.16e-05	170	78	5	23314748
Pubmed	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.	CNOT1 FKBP5 DYNC1H1	4.66e-05	31	78	3	28089446
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2	4.94e-05	5	78	2	18396275
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2	4.94e-05	5	78	2	22632968
Pubmed	Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.	KNTC1 NBAS	4.94e-05	5	78	2	20462495
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MDN1 GLE1 SGO2 UTP20 PUM3 PRPF8 CNOT1 TOP2B EXOC4	5.10e-05	759	78	9	35915203
Pubmed	Primary Ciliary Dyskinesia	DNAH5 DNAH8 HYDIN	5.14e-05	32	78	3	20301301
Pubmed	Defining the membrane proteome of NK cells.	NBAS IPO9 MDN1 GLE1 HUWE1 HEATR5B PRPF8 CNOT1 FKBP5 DYNC1H1 EXOC4	5.80e-05	1168	78	11	19946888
Pubmed	Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.	MAPK10 DYNC1H1	7.40e-05	6	78	2	19525941
Pubmed	Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.	AMPD2 AMPD3	7.40e-05	6	78	2	29079593
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	7.40e-05	6	78	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	7.40e-05	6	78	2	18827015
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	JUP ZNF609 IPO9 GLE1 TP53I11 PRPF8 RFX1 CNOT1 ZFP82 TOP2B EXOC4	7.55e-05	1203	78	11	29180619
Pubmed	Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.	IPO9 PIEZO1 HUWE1 PRPF8 MAPK10 CNOT1 DYNC1H1	8.29e-05	463	78	7	27503909
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	KNTC1 AMPD2 JUP ATP6V1C1 IPO9 SUGT1 HUWE1 CMYA5 CNOT1 NEK9 FKBP5 DYNC1H1	9.26e-05	1455	78	12	22863883
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH5 DNAH8	1.04e-04	7	78	2	9256245
Pubmed	A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.	RALGAPA2 EXOC4	1.04e-04	7	78	2	21148297
Pubmed	The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).	MET JUP	1.04e-04	7	78	2	12370829
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH5 DNAH8	1.04e-04	7	78	2	31178125
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	JUP MDN1 PRPF8 GFM1 CNOT1 DYNC1H1 TOP2B	1.09e-04	484	78	7	31995728
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MDN1 SYNE2 UTP20 PUM3 HUWE1 PRPF8 CNOT1 DYNC1H1	1.09e-04	653	78	8	22586326
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	MDN1 SUGT1 BTAF1 HUWE1 PRPF8 GFM1 CNOT1 NEK9 FKBP5 DYNC1H1 CDC45	1.11e-04	1257	78	11	37317656
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MDN1 UTP20 BTAF1 HUWE1 PRPF8 CABIN1 RFX1 DYNC1H1 TOP2B	1.28e-04	857	78	9	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AMPD2 JUP IPO9 MDN1 SYDE2 SYNE2 NEK9 DEPDC1B EXOC4	1.33e-04	861	78	9	36931259
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	GLE1 PRPF8 CNOT1	1.35e-04	44	78	3	26471122
Pubmed	Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.	UTP20 DNAH5	1.38e-04	8	78	2	17903303
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	SLC7A2 MDN1 SYDE2 SGO2 RALGAPA2 CABIN1	1.69e-04	363	78	6	14691545
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	AMPD2 ZNF609 IPO9 METTL9 PRPF8 RFX1 CNOT1 NEK9 DEPDC1B DYNC1H1 EXOC4	1.72e-04	1321	78	11	27173435
Pubmed	Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23.	MET MCF2	1.77e-04	9	78	2	1611909
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 SYNE1 PRPF8 DNAH5 TOP2B	1.87e-04	234	78	5	36243803
Pubmed	Nuclear membrane proteins with potential disease links found by subtractive proteomics.	SYNE1 SYNE2	2.21e-04	10	78	2	12958361
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE1 SYNE2	2.21e-04	10	78	2	28533284
Pubmed	Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.	NEK9 CDC45	2.21e-04	10	78	2	16902406
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	UBR1 IPO9 PRPF8 CNOT1 FKBP5 EXOC4	2.49e-04	390	78	6	17643375
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	AMPD2 IPO9 GLE1 UTP20 BTAF1 HUWE1 HEATR5B DYNC1H1 EXOC4	2.59e-04	942	78	9	31073040
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	SYNE1 PCLO	2.70e-04	11	78	2	20351715
Interaction	GPR17 interactions	KNTC1 NBAS SLC7A2 MDN1 UTP20 BTAF1 HEATR5B EXOC4	1.25e-05	283	77	8	int:GPR17
Interaction	LRRC31 interactions	KNTC1 NBAS UTP20 BTAF1 PRPF8 CNOT1 TOP2B	1.34e-05	205	77	7	int:LRRC31
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	4.30e-05	4	49	2	1252
GeneFamily	Topoisomerases	TOP1MT TOP2B	1.07e-04	6	49	2	1050
GeneFamily	Adenosine deaminase family	AMPD2 AMPD3	1.07e-04	6	49	2	1302
GeneFamily	Dyneins, axonemal	DNAH5 DNAH8	9.53e-04	17	49	2	536
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SYDE2 PCLO	4.27e-03	36	49	2	823
Coexpression	GSE22432_CDC_VS_COMMON_DC_PROGENITOR_DN	KNTC1 GLE1 SGO2 TOP1MT GFM1 TOP2B DSE CDC45	1.29e-07	199	77	8	M7824
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	UBR1 ZNF609 TRANK1 METTL9 SYNE1 IPCEF1 PIEZO1 GAB3 RAPGEF1 BTAF1 HUWE1 PRPF8 CNOT1 NEK9 FKBP5 DYNC1H1 TOP2B	1.19e-06	1492	77	17	M40023
Coexpression	HE_LIM_SUN_FETAL_LUNG_C5_CD5_POS_CCL22_POS_MATURE_B_CELL	AMPD3 MDN1 SYNE2 TP53I11 PUM3 HUWE1 TOP1MT HEATR5B FKBP5 DSE	2.48e-05	666	77	10	M45778
Coexpression	GSE21670_TGFB_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN	AMPD3 SYNE2 RALGAPA2 DNAH8 CNGA1 DSE	2.77e-05	200	77	6	M7432
Coexpression	LAKE_ADULT_KIDNEY_C3_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S1_S2	PCLO SYNE2 PUM3 MAPK10 FKBP5 EXOC4	4.83e-05	221	77	6	M39222
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF609 IPCEF1 SYNE2 DNAAF9 MAPK10 FKBP5 EXOC4	4.72e-08	192	78	7	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MET JUP ARHGAP40 SYNE1 IPCEF1 SYNE2 DNAH5	4.89e-08	193	78	7	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MET JUP ARHGAP40 SYNE1 IPCEF1 SYNE2 DNAH5	4.89e-08	193	78	7	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MET JUP SYNE1 IPCEF1 SYNE2 DNAH5 HYDIN	5.07e-08	194	78	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAHD2B TRANK1 SYNE1 SYNE2 CD274 GAB3	7.88e-07	181	78	6	5cecbafc29cc95896e6ccb2c74d9237b9aaece69
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 LOXHD1 HMCN1 PCLO DNAH5 HYDIN	8.67e-07	184	78	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 LOXHD1 HMCN1 PCLO DNAH5 HYDIN	8.67e-07	184	78	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 LOXHD1 HMCN1 PCLO DNAH5 HYDIN	8.67e-07	184	78	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	KNTC1 IPO9 SGO2 DEPDC1B FKBP5 CDC45	1.05e-06	190	78	6	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	MET SLC7A2 JUP MAPK10 DNAH5 HYDIN	1.11e-06	192	78	6	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	MET SYNE1 SYNE2 MAPK10 DNAH5 HYDIN	1.25e-06	196	78	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	MET SYNE1 SYNE2 MAPK10 DNAH5 HYDIN	1.25e-06	196	78	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDK4 SYNE1 SLC6A20 CDH19 MAPK10 FKBP5	1.41e-06	200	78	6	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDK4 SYNE1 SLC6A20 CDH19 MAPK10 FKBP5	1.41e-06	200	78	6	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	LPS-antiTNF-Unknown\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KNTC1 SGO2 CDH19 DEPDC1B CDC45	3.20e-06	129	78	5	739b263296c28554967362060b154f7a95e1341d
ToppCell	LPS-antiTNF-Unknown-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KNTC1 SGO2 CDH19 DEPDC1B CDC45	3.32e-06	130	78	5	615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MET SLC7A2 SYNE2 DNAH5 HYDIN	1.03e-05	164	78	5	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	METTL9 IPCEF1 CNPY3 DSE IGSF23	1.23e-05	170	78	5	46a81d505de845cc59f80594fce338f7fdb9250f
ToppCell	3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	METTL9 IPCEF1 CNPY3 DSE IGSF23	1.23e-05	170	78	5	1a9a0487c35cf3fd5806d1f0f0e91ef0e0b9cd0a
ToppCell	3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	METTL9 IPCEF1 CNPY3 DSE IGSF23	1.23e-05	170	78	5	830646815410c47e9bca8c9bae75dfc45c9c9b33
ToppCell	facs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METTL9 SYNE1 SYNE2 SGO2 CDC45	1.26e-05	171	78	5	95e87987a2332fa646849fb0de785f1e0b8a07dd
ToppCell	facs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METTL9 SYNE1 SYNE2 SGO2 CDC45	1.26e-05	171	78	5	36657e277aad75c4f157c1726c48e09b5836cf37
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	MET ARHGAP40 MAPK10 DNAH5 CDON	1.66e-05	181	78	5	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 PDK4 CMYA5 MAPK10 IGSF23	1.99e-05	188	78	5	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 PDK4 CMYA5 MAPK10 IGSF23	1.99e-05	188	78	5	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 PDK4 CMYA5 MAPK10 IGSF23	1.99e-05	188	78	5	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 PDK4 CMYA5 MAPK10 IGSF23	2.04e-05	189	78	5	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MET ARHGAP40 IPCEF1 DNAH5 HYDIN	2.04e-05	189	78	5	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MET ARHGAP40 IPCEF1 DNAH5 HYDIN	2.04e-05	189	78	5	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 PDK4 CMYA5 MAPK10 IGSF23	2.04e-05	189	78	5	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	PDK4 SYNE1 CD274 RAPGEF1 FKBP5	2.10e-05	190	78	5	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MET IPCEF1 SYNE2 DNAH5 HYDIN	2.15e-05	191	78	5	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 UBR1 NBAS HUWE1 EXOC4	2.15e-05	191	78	5	9454f642c3621370fa23640b631301346b300950
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC7A2 PCLO SLC6A20 MAPK10 DNAH5	2.20e-05	192	78	5	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MET IPCEF1 SYNE2 CMYA5 MAPK10	2.32e-05	194	78	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP6V1C1 TRANK1 PCLO SCN8A MAPK10	2.32e-05	194	78	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 SYNE2 MAPK10 DNAH5 HYDIN	2.37e-05	195	78	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	HMCN1 SYNE1 SYNE2 RAPGEF1 RALGAPA2	2.37e-05	195	78	5	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	Control-CD8+_Tem\|Control / Disease condition and Cell class	SYNE1 SYNE2 TP53I11 GAB3 RAPGEF1	2.37e-05	195	78	5	7503b3e032f95b350a2782d28e4d412a8dc9ebcc
ToppCell	Healthy/Control-T/NK_proliferative\|Healthy/Control / Disease group and Cell class	KNTC1 SGO2 DEPDC1B HYDIN CDC45	2.37e-05	195	78	5	957458fdc39723f4a31bd7fd3ce32891aa3fd462
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	SYNE1 SYNE2 MAPK10 DNAH5 HYDIN	2.37e-05	195	78	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	JUP HMCN1 PIEZO1 TP53I11 RALGAPA2	2.37e-05	195	78	5	6b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MET PDK4 SYNE2 MAPK10 HYDIN	2.49e-05	197	78	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 SYNE2 MAPK10 DNAH5 HYDIN	2.49e-05	197	78	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MET JUP PLB1 PDK4 PIEZO1	2.49e-05	197	78	5	ed3a37f532741764060d297a560eeeeec279d9c4
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	HMCN1 SYNE1 SYNE2 RAPGEF1 RALGAPA2	2.49e-05	197	78	5	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AMPD3 METTL9 SYNE1 IPCEF1 SYNE2	2.55e-05	198	78	5	3bc05b8d97a7219af40db7a11aa271f02e74fca5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDK4 IPCEF1 GAB3 CNPY3 BTAF1	2.61e-05	199	78	5	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	KNTC1 NBAS IPO9 SGO2 CDC45	2.68e-05	200	78	5	d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	KNTC1 NBAS IPO9 SGO2 CDC45	2.68e-05	200	78	5	3d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	ZNF609 TRANK1 MDN1 IPCEF1 SYNE2	2.68e-05	200	78	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	TRANK1 SYNE1 SYNE2 RAPGEF1 HUWE1	2.68e-05	200	78	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	COVID-19_Severe-Classical_Monocyte-\|Classical_Monocyte / Disease condition and Cell class	LOXHD1 CD274 SGO2 PUM3	9.58e-05	136	78	4	e272d11bb52f890f6681cc9384aeac27976ec650
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC7A2 AMPD2 NUP210L SGO2	1.16e-04	143	78	4	b4ed3855652fdf32f97cb7c18cab4f4f4c24d5c7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175\|Adult / Lineage, Cell type, age group and donor	MET ARHGAP40 HMCN1 DNAH5	1.40e-04	150	78	4	b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC7A2 PDK4 PIEZO1 CNGA1	1.43e-04	151	78	4	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACTL7B MET ARHGAP40 DNAH5	1.75e-04	159	78	4	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBAS NUP210L SCN8A TP53I11	1.92e-04	163	78	4	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KNTC1 SGO2 DEPDC1B CDC45	1.92e-04	163	78	4	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBAS NUP210L SCN8A TP53I11	1.92e-04	163	78	4	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KNTC1 SCN8A SGO2 FKBP5	1.97e-04	164	78	4	e5258efd6765acfc394708f697ec76acaef09079
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KNTC1 SGO2 DEPDC1B CDC45	2.01e-04	165	78	4	a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCell	droplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 SCN8A SGO2 CDC45	2.01e-04	165	78	4	96f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCell	facs-Heart-LA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 CMYA5 MAPK10 IGSF23	2.06e-04	166	78	4	829a8998ce68739a58202851afd73e049ab0f84f
ToppCell	facs-Lung-nan-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MET AMPD2 NUP210L UEVLD	2.06e-04	166	78	4	5c132f505dc5f699c87913f140344fc9f8e7e0f5
ToppCell	facs-Heart-LA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 CMYA5 MAPK10 IGSF23	2.06e-04	166	78	4	c43aec09578975df8984886993d15b42a10190c8
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARHGAP40 HEATR5B CNGA1 CDON	2.11e-04	167	78	4	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MET PCLO CD274 IGSF23	2.16e-04	168	78	4	e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MET PCLO CD274 IGSF23	2.16e-04	168	78	4	403aba73a0f9ffb32252288d075fad8a588ca440
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MET SYNE2 SLC17A4 HYDIN	2.16e-04	168	78	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KNTC1 SGO2 DEPDC1B CDC45	2.21e-04	169	78	4	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	Dividing_Macrophages-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	PDK4 SGO2 DEPDC1B CDC45	2.21e-04	169	78	4	bc859a103cad567caf50c3c3882d2d2017807c73
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 PCLO DNAH5 HYDIN	2.21e-04	169	78	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRANK1 IPCEF1 CD274 RALGAPA2	2.26e-04	170	78	4	07b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMPD3 METTL9 SYNE1 IPCEF1	2.31e-04	171	78	4	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMPD3 METTL9 SYNE1 IPCEF1	2.31e-04	171	78	4	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MET ARHGAP40 IPCEF1 DNAH5	2.36e-04	172	78	4	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD274 SGO2 CNGA1 CDC45	2.36e-04	172	78	4	ba36581ae339191a12a6d3ead39eaf69d78be10e
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MET HMCN1 CMYA5 CABIN1	2.36e-04	172	78	4	c6bc78fd63c9479a84ec0552b55c89750cad0fa5
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MET HMCN1 CMYA5 CABIN1	2.36e-04	172	78	4	bfb87a281a9cf6ad45b310bf8104fc0ab382b549
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 CD274 SGO2 CDC45	2.36e-04	172	78	4	94093d356b0252b440deda4e1b0ac332b31513f6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MET ARHGAP40 IPCEF1 DNAH5	2.36e-04	172	78	4	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK\|bone_marrow / Manually curated celltypes from each tissue	SLC6A20 SGO2 DEPDC1B CDC45	2.41e-04	173	78	4	8a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK4 SYNE2 SLC17A4 FKBP5	2.41e-04	173	78	4	e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell	facs-Large_Intestine-Proximal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK4 SYNE2 SLC17A4 FKBP5	2.41e-04	173	78	4	99532bb768ee35fed939a377acb5215d3f8904bd
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE2 SGO2 DNAH8 DEPDC1B	2.47e-04	174	78	4	9d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE2 SGO2 DNAH8 DEPDC1B	2.47e-04	174	78	4	53cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KNTC1 SGO2 DEPDC1B CDC45	2.52e-04	175	78	4	876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KNTC1 TOP1MT DEPDC1B FKBP5	2.58e-04	176	78	4	9e719e6323597ecfc758c957256872cd4ae24d4d
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	MET JUP HMCN1 SYNE2	2.58e-04	176	78	4	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	MET ARHGAP40 MAPK10 DNAH5	2.58e-04	176	78	4	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	MDN1 SYNE1 DNAAF9 DYNC1H1	2.63e-04	177	78	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUP210L SYNE1 SYNE2 CD274	2.69e-04	178	78	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METTL9 SYNE1 SYNE2 SGO2	2.69e-04	178	78	4	15a99080e9f669572ab6d82934f324e6714846c1
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	METTL9 SYNE1 SYNE2 SGO2	2.69e-04	178	78	4	200308e109abb7e6f8816a6f8cce6d56862d4098
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGO2 DNAH5 HYDIN CDON	2.69e-04	178	78	4	6178706db4a855d72abc156537604d575624df56
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MET SYNE2 SLC17A4 HYDIN	2.69e-04	178	78	4	544379f5a6145429762258d426b876bb36c112f5
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGO2 DNAH5 HYDIN CDON	2.69e-04	178	78	4	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MET ARHGAP40 MAPK10 DNAH5	2.81e-04	180	78	4	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	368C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MDN1 SGO2 CDON UEVLD	2.81e-04	180	78	4	eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
Drug	plakin	ACTL7B JUP SYNE1 SYNE2 DYNC1H1	8.64e-06	82	77	5	CID000018752
Drug	neplanocin	AMPD2 AMPD3 SYNE1	1.04e-05	13	77	3	CID005289040
Drug	AC1NSWD2	SYNE1 TOP2B	1.13e-05	2	77	2	CID005318091
Drug	CI-937	TOP1MT MAPK10 TOP2B	1.32e-05	14	77	3	CID005364123
Drug	Abbott-40557	AMPD2 AMPD3	3.38e-05	3	77	2	CID000161884
Drug	C-d4G	AMPD2 AMPD3	3.38e-05	3	77	2	CID000461321
Drug	AC1LAJJO	AMPD2 AMPD3	3.38e-05	3	77	2	CID000469587
Drug	AC1LANXR	AMPD2 AMPD3	3.38e-05	3	77	2	CID000471863
Drug	aminoflavone	SYNE1 TOP1MT TOP2B	4.07e-05	20	77	3	CID000389710
Drug	Oxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A	SLC7A2 AMPD3 ZNF609 SCN8A TP53I11 CDON	5.23e-05	195	77	6	4124_UP
Drug	Guanabenz acetate [23256-50-0]; Up 200; 13.8uM; MCF7; HT_HG-U133A	SLC7A2 PCLO TP53I11 RAPGEF1 NEK9 CDON	5.53e-05	197	77	6	5703_UP
Drug	4-hydroxymethyl-4',5'-benzopsoralen	TOP1MT TOP2B	6.74e-05	4	77	2	CID000147789
Drug	2'-deoxycoformycin-5'-phosphate	AMPD2 AMPD3	6.74e-05	4	77	2	CID000188258
Drug	inosine 5'-phosphosulfate	AMPD2 AMPD3	6.74e-05	4	77	2	CID003082299
Drug	methylphenylcarbamate	TOP1MT TOP2B	6.74e-05	4	77	2	CID000017451
Drug	mitindomide	TOP1MT TOP2B	6.74e-05	4	77	2	CID000066362
Drug	2',3'-Dideoxyadenylosuccinate	AMPD2 AMPD3	6.74e-05	4	77	2	CID000126574
Drug	2-fluoro-dATP	TOP1MT TOP2B	6.74e-05	4	77	2	CID000126365
Drug	dioxazine	TOP1MT TOP2B	6.74e-05	4	77	2	CID011969523
Drug	3-O-alpha-L-arabinopyranosyl-oleanolic acid	TOP1MT TOP2B	6.74e-05	4	77	2	CID000124369
Drug	A-74932	TOP1MT TOP2B	6.74e-05	4	77	2	CID000132825
Drug	20,29-dihydrobetulinic acid	TOP1MT TOP2B	6.74e-05	4	77	2	CID000065319
Drug	tumulosic acid	TOP1MT TOP2B	6.74e-05	4	77	2	CID005322174
Drug	NSC 380271	TOP1MT TOP2B	6.74e-05	4	77	2	CID000342690
Drug	AC1LAIW3	MET TOP1MT MAPK10 TOP2B	1.04e-04	72	77	4	CID000469261
Drug	cupric acetate monohydrate	DNAH5 DYNC1H1	1.12e-04	5	77	2	CID000165397
Drug	NSC 314622	TOP1MT TOP2B	1.12e-04	5	77	2	CID000329826
Drug	2,3-dibromopropene	AMPD2 AMPD3	1.12e-04	5	77	2	CID000010552
Drug	4-acetylpyridine	SYNE1 DYNC1H1	1.12e-04	5	77	2	CID000014282
Drug	2-bromo-dATP	TOP1MT TOP2B	1.12e-04	5	77	2	CID000129443
Drug	3aH-benzimidazole	TOP1MT TOP2B	1.12e-04	5	77	2	CID009548683
Drug	11-deoxydaunorubicin	TOP1MT TOP2B	1.12e-04	5	77	2	CID000158483
Drug	4-demethoxy-11-deoxy-4'-epi-daunorubicin	TOP1MT TOP2B	1.12e-04	5	77	2	CID000158476
Drug	2,6-diaminopurine analog	AMPD2 AMPD3	1.12e-04	5	77	2	CID000469176
Drug	AC1L43MI	TOP1MT TOP2B	1.12e-04	5	77	2	CID000150081
Drug	NSC622082	TOP1MT TOP2B	1.12e-04	5	77	2	CID000494392
Drug	CBVMP	AMPD2 AMPD3	1.12e-04	5	77	2	CID000469585
Drug	elomotecan	TOP1MT TOP2B	1.12e-04	5	77	2	CID000216300
Drug	4-demethyl-6-O-methyldoxorubicin	TOP1MT TOP2B	1.12e-04	5	77	2	CID000126902
Drug	eupolauridine	TOP1MT TOP2B	1.12e-04	5	77	2	CID000072486
Drug	proton sponge	SYNE1 GFM1	1.68e-04	6	77	2	CID000088675
Drug	intoplicine	TOP1MT TOP2B	1.68e-04	6	77	2	CID000065954
Drug	NSC623156	AMPD2 AMPD3	1.68e-04	6	77	2	CID000360780
Drug	DMP 840	TOP1MT TOP2B	1.68e-04	6	77	2	CID000060916
Drug	BE-10988	TOP1MT TOP2B	1.68e-04	6	77	2	CID000126200
Drug	galbacin	TOP1MT TOP2B	1.68e-04	6	77	2	CID000234441
Drug	UCE6	TOP1MT TOP2B	1.68e-04	6	77	2	CID000127735
Drug	DBTA	DNAH5 DYNC1H1	1.68e-04	6	77	2	CID000149053
Drug	dimethoxyphenol	SYNE1 TOP2B	1.68e-04	6	77	2	CID000078828
Drug	berberrubine	TOP1MT TOP2B	1.68e-04	6	77	2	CID000072703
Drug	saintopin	TOP1MT TOP2B	1.68e-04	6	77	2	CID000131350
Drug	NSC339663	ACTL7B SYNE1 SYNE2 MCF2 RAPGEF1 EXOC4	2.04e-04	250	77	6	CID000003892
Drug	NBQCl	TOP1MT TOP2B	2.34e-04	7	77	2	CID000134086
Drug	coaristeromycin	AMPD2 AMPD3	2.34e-04	7	77	2	CID000097182
Drug	adenosine-5'-carboxylic acid	AMPD2 AMPD3	2.34e-04	7	77	2	CID000097627
Drug	nitidine	TOP1MT TOP2B	2.34e-04	7	77	2	CID000004501
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	3.81e-05	4	75	2	cv:CN293514
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	6.34e-05	5	75	2	C1450051
Disease	pontocerebellar hypoplasia (implicated_via_orthology)	AMPD2 AMPD3	6.34e-05	5	75	2	DOID:0060264 (implicated_via_orthology)
Disease	Cerebellar Ataxia	SYNE1 SCN8A	6.34e-05	5	75	2	C0007758
Disease	fecal incontinence	PLB1 CDH19	6.34e-05	5	75	2	EFO_0009523
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	6.34e-05	5	75	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	9.50e-05	6	75	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	9.50e-05	6	75	2	C0410189
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.33e-04	7	75	2	C0751337
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	4.14e-04	12	75	2	DOID:11726 (implicated_via_orthology)
Disease	Pontoneocerebellar hypoplasia	AMPD2 PCLO	7.48e-04	16	75	2	cv:C1261175
Disease	periodontitis (biomarker_via_orthology)	MET CD274	1.30e-03	21	75	2	DOID:824 (biomarker_via_orthology)
Disease	Bipolar Disorder	TRANK1 SYNE1 PCLO SCN8A DNAH8 FKBP5	1.36e-03	477	75	6	C0005586
Disease	blood pressure	SYNE1 EXOC4	1.42e-03	22	75	2	EFO_0004325
Disease	serum gamma-glutamyl transferase measurement	UBR1 MET PLB1 TRANK1 NUP210L CABIN1 FKBP5 EXOC4	2.22e-03	914	75	8	EFO_0004532
Disease	S-6-hydroxywarfarin measurement	HMCN1 PCLO UTP20 BTAF1 CDH19	2.48e-03	368	75	5	EFO_0803326

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQDIWEYIFRTAMKI	ACTL7B	126	Q9Y614
VDSYMAIVNKTVWDL	DNM1P46	61	Q6ZS02
NVEEIWKSMTLSYLQ	DEPDC1B	181	Q8WUY9
EDLQVKVQDITMQWY	GLE1	376	Q53GS7
LMEEYSIATQVWKLS	AMPD2	776	Q01433
VNIYLMVQLSADTWV	SLC7A2	571	P52569
MEEYAIAAQVWKLST	AMPD3	676	Q01432
AALIVYWEMEDKNII	CD274	51	Q9NZQ7
IMWNALYTAEKVIIR	TP53I11	116	O14683
KTMYLEDQIVQLQLW	RAB41	71	Q5JT25
NYDIVVRAKQMWEIL	PUM3	131	Q15397
QLVKSWYIQSLMDLV	PDK4	86	Q16654
QAVIQYGKIVSWLEM	FKBP5	286	Q13451
EKVAAEMWQSYLILT	MDN1	5306	Q9NU22
TIEEWKELIYKEVMN	MAPK10	386	P53779
EMVVWYLFQIVSAVS	NEK9	151	Q8TD19
YLVAKTEQEMQVWVH	GAB3	96	Q8WWW8
VNIGVKVLYEMTVWT	LOXHD1	1546	Q8IVV2
PEWNQTVIYKSISME	PCLO	4766	Q9Y6V0
QYERLKLTWQQVVML	KAT14	116	Q9H8E8
QLEEVLMVWYKQIEQ	DNAH8	141	Q96JB1
LMVWYKQIEQVLIES	DNAH8	146	Q96JB1
YATELSETMIWQLQK	METTL9	171	Q9H1A3
LQEAYLWTKQVLTIM	DSE	226	Q9UL01
LKAQWITYETTQEML	KNTC1	476	P50748
QMVFKTEDLIAWVSQ	FAHD2A	251	Q96GK7
DVLQLLVSYWEKLQM	RALGAPA2	1206	Q2PPJ7
YRDMILKQVVNQVWE	HUWE1	1476	Q7Z6Z7
QLTVEKVMDWYQTRA	NBAS	836	A2RRP1
LMEQPIKVTEWQQTY	JUP	6	P14923
IIMWYKDNVQVTESS	HMCN1	1391	Q96RW7
WVKIQDVLQMLLTEY	EXOC4	386	Q96A65
DQWVQDKITQMKYVT	CDC45	226	O75419
SELNYSVILQWVVTM	IGSF23	61	A1L1A6
ELTLKDVQNILMYWD	HYDIN	2461	Q4G0P3
REWKVMNTLLIQDIY	IPCEF1	391	Q8WWN9
AVLKAWAEVYVVAMN	HEATR5B	1421	Q9P2D3
AVMLDSTDVNLWYKI	CABIN1	116	Q9Y6J0
VWMELLSKASVQYVV	BTAF1	586	O14981
QMVFKTEDLIAWVSQ	FAHD2B	251	Q6P2I3
SYVAIVNKTVWDLMV	DNM1P34	41	Q6PK57
VKVVMDIPYELWNET	CNPY3	141	Q9BT09
TTIAVYWSMNKEDVI	CMYA5	3721	Q8N3K9
EAVSDTQIMLKWTYI	CDON	836	Q4KMG0
MKYELQDVSLNLWNV	DNAAF9	201	Q5TEA3
VYIVQASNVDVKMTW	MCF2	786	P10911
LYMQITEEQIKVWTA	IPO9	366	Q96P70
MGIVSEVEQYVKVWL	DYNC1H1	1041	Q14204
ATYTMWKDVNINIID	GFM1	106	Q96RP9
AQVMVLTGQYSIWVK	SLC17A4	176	Q9Y2C5
LQDEYWVIIQAKDMI	CDH19	216	Q9H159
MTVQNLWIYLEAVFV	DNAH5	1626	Q8TE73
EVALVTWQSVKEMVF	NUP210L	661	Q5VU65
VWKDNINMALVVDTY	MET	111	P08581
GLIYVKVTLMEQWEN	SYDE2	786	Q5VT97
IKMVTDIFLDWESYQ	UTP20	1156	O75691
DWIKQYETLAEMVVP	ATP6V1C1	196	P21283
TWTQVYKEQVLEPML	TOP2B	951	Q02880
MNVVEVFLEKFTTEW	SYNE1	4246	Q8NF91
SMQSVLQEWKIYDQL	SYNE2	5271	Q8WXH0
DVMVNLQFTLVETLW	RFX1	621	P22670
NWKTEIISEMNQIYE	SGO2	911	Q562F6
TRLAKVVMQWSYQEA	PLB1	246	Q6P1J6
AIKNMEVSQLWSVLY	SLC6A20	381	Q9NP91
ISNLVMYIVIIIHWN	CNGA1	296	P29973
TVKEEFMPWVSQYLV	CNOT1	1121	A5YKK6
VMDSTTTQKYWIDIQ	PRPF8	1651	Q6P2Q9
EVVQIMVHYQDLLWT	ARHGAP40	456	Q5TG30
YWVRSIIMLQEKAQD	RAPGEF1	891	Q13905
MLVVNVTWRNKTYVG	ZNF609	326	O15014
AWTESVQNSIKYIML	TOP1MT	251	Q969P6
SVIKYVVEMTIWEEE	UBR1	196	Q8IWV7
QSKQMENILYWINLV	SCN8A	1546	Q9UQD0
WYQTESQVVITLMIK	SUGT1	176	Q9Y2Z0
NDIYEINLSQWKIME	ZFP82	91	Q8N141
VASQPVEIMTYVTWK	UEVLD	291	Q8IX04
YTVWVALKEVSVMNL	PIEZO1	821	Q92508
YEKMEQVPKLVQWLI	TRANK1	176	O15050
SLVVMLYVIWVQAVA	TMEM182	161	Q6ZP80