Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1S

9.92e-0714293GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D

2.03e-055292GO:0086007
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1S

4.01e-0546293GO:0005245
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1C CACNA1D CACNA1S

8.51e-04129293GO:0005262
GeneOntologyMolecularFunctionalpha-actinin binding

CACNA1C CACNA1D

9.23e-0431292GO:0051393
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1S

1.34e-03151293GO:0015085
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C CACNA1D CACNA1S

1.37e-03152293GO:0022843
GeneOntologyMolecularFunctionactinin binding

CACNA1C CACNA1D

1.77e-0343292GO:0042805
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1C CACNA1D CACNA1S

2.29e-03182293GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1C CACNA1D CACNA1S

2.36e-03184293GO:0022832
GeneOntologyMolecularFunctioncalmodulin binding

CACNA1C CACNA1S MYO5A

4.42e-03230293GO:0005516
GeneOntologyBiologicalProcesscalcium ion import

CACNA1C CACNA1D CACNA1S EPPIN

7.73e-0698274GO:0070509
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

1.65e-055272GO:1904879
GeneOntologyBiologicalProcessregulation of heart rate by cardiac conduction

CACNA1C CACNA1D DSP

2.06e-0541273GO:0086091
GeneOntologyBiologicalProcessregulation of heart rate

CACNA1C CACNA1D DSP CHRM3

2.29e-05129274GO:0002027
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1C CACNA1D CACNA1S

3.33e-0548273GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1C CACNA1D CACNA1S

3.33e-0548273GO:1902656
GeneOntologyBiologicalProcessactin filament-based movement

CACNA1C CACNA1D MYO5A DSP

4.47e-05153274GO:0030048
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

CACNA1C CACNA1D DSP

6.19e-0559273GO:0086065
GeneOntologyBiologicalProcesspositive regulation of muscle contraction

CACNA1C CACNA1S CHRM3

6.19e-0559273GO:0045933
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA1C CACNA1D DSP

7.19e-0562273GO:0086002
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell action potential

CACNA1C DSP

1.08e-0412272GO:0098911
GeneOntologyBiologicalProcessregulation of muscle contraction

CACNA1C CACNA1S DSP CHRM3

1.31e-04202274GO:0006937
GeneOntologyBiologicalProcessmuscle contraction

CACNA1C CACNA1D CACNA1S DSP CHRM3

1.52e-04400275GO:0006936
GeneOntologyBiologicalProcessstriated muscle contraction

CACNA1C CACNA1D CACNA1S DSP

1.73e-04217274GO:0006941
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1C CACNA1D CACNA1S MYO5A

1.73e-04217274GO:0097553
GeneOntologyBiologicalProcesspositive regulation of membrane depolarization

CACNA1C CACNA1D

1.96e-0416272GO:1904181
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA1C CACNA1D DSP

1.97e-0487273GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

CACNA1C CACNA1D DSP

2.40e-0493273GO:0086003
GeneOntologyBiologicalProcessregulation of heart contraction

CACNA1C CACNA1D DSP CHRM3

2.92e-04249274GO:0008016
GeneOntologyBiologicalProcesscardiac conduction

CACNA1C CACNA1D DSP

2.97e-04100273GO:0061337
GeneOntologyBiologicalProcessregulation of calcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

3.75e-0422272GO:1902514
GeneOntologyBiologicalProcessmembrane depolarization during cardiac muscle cell action potential

CACNA1C CACNA1D

4.10e-0423272GO:0086012
GeneOntologyBiologicalProcesscalcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

4.10e-0423272GO:0061577
GeneOntologyBiologicalProcessinsulin secretion

CACNA1C CACNA1D MYO5A CHRM3

4.20e-04274274GO:0030073
GeneOntologyBiologicalProcesscalcium ion transport

CACNA1C CACNA1D CACNA1S EPPIN MYO5A

4.62e-04509275GO:0006816
GeneOntologyBiologicalProcesspositive regulation of insulin secretion

CACNA1C CACNA1D CHRM3

5.07e-04120273GO:0032024
GeneOntologyBiologicalProcessheart contraction

CACNA1C CACNA1D DSP CHRM3

5.77e-04298274GO:0060047
GeneOntologyBiologicalProcessactin-mediated cell contraction

CACNA1C CACNA1D DSP

5.98e-04127273GO:0070252
GeneOntologyBiologicalProcessmuscle system process

CACNA1C CACNA1D CACNA1S DSP CHRM3

6.41e-04547275GO:0003012
GeneOntologyBiologicalProcessheart process

CACNA1C CACNA1D DSP CHRM3

6.60e-04309274GO:0003015
GeneOntologyBiologicalProcessregulation of cardiac muscle cell action potential

CACNA1C DSP

7.02e-0430272GO:0098901
GeneOntologyBiologicalProcessregulation of muscle system process

CACNA1C CACNA1S DSP CHRM3

7.27e-04317274GO:0090257
GeneOntologyBiologicalProcessregulation of calcium ion transport

CACNA1C CACNA1D EPPIN MYO5A

7.79e-04323274GO:0051924
GeneOntologyBiologicalProcessregulation of blood circulation

CACNA1C CACNA1D DSP CHRM3

8.07e-04326274GO:1903522
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1C CACNA1D CACNA1S

8.28e-04142273GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1C CACNA1D CACNA1S

8.28e-04142273GO:0098659
GeneOntologyBiologicalProcesspeptide hormone secretion

CACNA1C CACNA1D MYO5A CHRM3

8.83e-04334274GO:0030072
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

CACNA1C CACNA1S MYO5A

8.97e-04146273GO:0051209
GeneOntologyBiologicalProcesscell-cell signaling involved in cardiac conduction

CACNA1C CACNA1D

9.02e-0434272GO:0086019
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

CACNA1C CACNA1S MYO5A

9.15e-04147273GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

CACNA1C CACNA1S MYO5A

9.52e-04149273GO:0051282
GeneOntologyBiologicalProcesspeptide secretion

CACNA1C CACNA1D MYO5A CHRM3

9.75e-04343274GO:0002790
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA1C CACNA1D

1.01e-0336272GO:0086010
GeneOntologyBiologicalProcesssequestering of calcium ion

CACNA1C CACNA1S MYO5A

1.03e-03153273GO:0051208
GeneOntologyBiologicalProcessventricular cardiac muscle cell action potential

CACNA1C DSP

1.07e-0337272GO:0086005
GeneOntologyBiologicalProcesspositive regulation of peptide hormone secretion

CACNA1C CACNA1D CHRM3

1.11e-03157273GO:0090277
GeneOntologyBiologicalProcesspeptide transport

CACNA1C CACNA1D MYO5A CHRM3

1.11e-03355274GO:0015833
GeneOntologyBiologicalProcesspositive regulation of peptide secretion

CACNA1C CACNA1D CHRM3

1.19e-03161273GO:0002793
GeneOntologyBiologicalProcesspositive regulation of adenylate cyclase activity

CACNA1C CACNA1D

1.25e-0340272GO:0045762
GeneOntologyBiologicalProcesscardiac muscle contraction

CACNA1C CACNA1D DSP

1.32e-03167273GO:0060048
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

CACNA1C DSP

1.44e-0343272GO:0086004
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNA1C CACNA1D CACNA1S MYO5A

1.59e-03392274GO:0070588
GeneOntologyBiologicalProcesspositive regulation of cyclase activity

CACNA1C CACNA1D

1.79e-0348272GO:0031281
GeneOntologyBiologicalProcesspositive regulation of lyase activity

CACNA1C CACNA1D

1.87e-0349272GO:0051349
GeneOntologyBiologicalProcesspositive regulation of protein secretion

CACNA1C CACNA1D CHRM3

2.03e-03194273GO:0050714
GeneOntologyBiologicalProcesshormone secretion

CACNA1C CACNA1D MYO5A CHRM3

2.05e-03420274GO:0046879
GeneOntologyBiologicalProcessamide transport

CACNA1C CACNA1D MYO5A CHRM3

2.05e-03420274GO:0042886
GeneOntologyBiologicalProcesscamera-type eye development

CACNA1C CACNA1S USP45 ANGPTL7

2.16e-03426274GO:0043010
GeneOntologyBiologicalProcessregulation of actin filament-based movement

CACNA1C DSP

2.18e-0353272GO:1903115
GeneOntologyBiologicalProcessaction potential

CACNA1C CACNA1D DSP

2.24e-03201273GO:0001508
GeneOntologyBiologicalProcesshormone transport

CACNA1C CACNA1D MYO5A CHRM3

2.27e-03432274GO:0009914
GeneOntologyBiologicalProcessregulation of system process

CACNA1C CACNA1D CACNA1S DSP CHRM3

2.37e-03734275GO:0044057
GeneOntologyBiologicalProcesspositive regulation of hormone secretion

CACNA1C CACNA1D CHRM3

2.37e-03205273GO:0046887
GeneOntologyBiologicalProcessregulation of adenylate cyclase activity

CACNA1C CACNA1D

2.70e-0359272GO:0045761
GeneOntologyBiologicalProcessregulation of calcium ion transmembrane transport

CACNA1C CACNA1D MYO5A

2.82e-03218273GO:1903169
GeneOntologyBiologicalProcessregulation of membrane depolarization

CACNA1C CACNA1D

2.88e-0361272GO:0003254
GeneOntologyBiologicalProcessimport across plasma membrane

CACNA1C CACNA1D CACNA1S

3.29e-03230273GO:0098739
GeneOntologyBiologicalProcessprotein secretion

CACNA1C CACNA1D MYO5A CHRM3

3.32e-03480274GO:0009306
GeneOntologyBiologicalProcesseye development

CACNA1C CACNA1S USP45 ANGPTL7

3.32e-03480274GO:0001654
GeneOntologyBiologicalProcessregulation of insulin secretion

CACNA1C CACNA1D CHRM3

3.33e-03231273GO:0050796
GeneOntologyBiologicalProcessestablishment of protein localization to extracellular region

CACNA1C CACNA1D MYO5A CHRM3

3.40e-03483274GO:0035592
GeneOntologyBiologicalProcessvisual system development

CACNA1C CACNA1S USP45 ANGPTL7

3.40e-03483274GO:0150063
GeneOntologyBiologicalProcessprotein localization to extracellular region

CACNA1C CACNA1D MYO5A CHRM3

3.58e-03490274GO:0071692
GeneOntologyBiologicalProcesssensory system development

CACNA1C CACNA1S USP45 ANGPTL7

3.60e-03491274GO:0048880
GeneOntologyBiologicalProcessregulation of metal ion transport

CACNA1C CACNA1D EPPIN MYO5A

3.66e-03493274GO:0010959
GeneOntologyBiologicalProcessregulation of cyclase activity

CACNA1C CACNA1D

3.67e-0369272GO:0031279
GeneOntologyBiologicalProcessregulation of lyase activity

CACNA1C CACNA1D

4.10e-0373272GO:0051339
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transporter activity

CACNA1D MYO5A CHRM3

4.43e-03256273GO:0032412
GeneOntologyBiologicalProcessmaintenance of location in cell

CACNA1C CACNA1S MYO5A

4.58e-03259273GO:0051651
GeneOntologyCellularComponentL-type voltage-gated calcium channel complex

CACNA1C CACNA1D CACNA1S

4.70e-0712283GO:1990454
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1D CACNA1S

3.14e-0546283GO:0005891
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1D CACNA1S

1.26e-0473283GO:0034704
GeneOntologyCellularComponentT-tubule

CACNA1C CACNA1D CACNA1S

1.59e-0479283GO:0030315
GeneOntologyCellularComponentpresynaptic membrane

CACNA1C CACNA1D FCHO2 CHRM3

4.81e-04277284GO:0042734
GeneOntologyCellularComponentdendrite

CACNA1C CACNA1D CACNA1S ATXN10 MYO5A CHRM3

8.15e-04858286GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNA1C CACNA1D CACNA1S ATXN10 MYO5A CHRM3

8.25e-04860286GO:0097447
GeneOntologyCellularComponentI band

CACNA1C CACNA1D CACNA1S

1.39e-03166283GO:0031674
GeneOntologyCellularComponentsarcolemma

CACNA1C CACNA1D CACNA1S

2.05e-03190283GO:0042383
GeneOntologyCellularComponentcation channel complex

CACNA1C CACNA1D CACNA1S

3.73e-03235283GO:0034703
DomainVDCC_L_a1su

CACNA1C CACNA1D CACNA1S

1.34e-084293IPR005446
DomainGPHH_dom

CACNA1C CACNA1D CACNA1S

1.17e-077293IPR031649
DomainVDCC_a1su_IQ

CACNA1C CACNA1D CACNA1S

1.17e-077293IPR014873
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1S

1.17e-077293SM01062
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1S

1.17e-077293PF08763
DomainGPHH

CACNA1C CACNA1D CACNA1S

1.17e-077293PF16905
DomainVDCCAlpha1

CACNA1C CACNA1D CACNA1S

4.01e-0710293IPR002077
DomainCAC1F_C

CACNA1C CACNA1D

6.98e-063292PF16885
DomainCAC1F_C

CACNA1C CACNA1D

6.98e-063292IPR031688
DomainChannel_four-helix_dom

CACNA1C CACNA1D CACNA1S

9.31e-0557293IPR027359
Domain-

CACNA1C CACNA1D CACNA1S

9.31e-05572931.20.120.350
Domain-

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

5.24e-046792963.30.160.60
Domainzf-C2H2

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

5.84e-04693296PF00096
DomainZnf_C2H2/integrase_DNA-bd

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

5.89e-04694296IPR013087
DomaintRNA-bd_arm

PIBF1 DSP

6.29e-0424292IPR010978
DomainIon_trans_dom

CACNA1C CACNA1D CACNA1S

7.21e-04114293IPR005821
DomainIon_trans

CACNA1C CACNA1D CACNA1S

7.21e-04114293PF00520
DomainZINC_FINGER_C2H2_2

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

1.05e-03775296PS50157
DomainZINC_FINGER_C2H2_1

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

1.06e-03777296PS00028
DomainZnf_C2H2-like

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

1.20e-03796296IPR015880
DomainZnf_C2H2

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

1.28e-03805296IPR007087
DomainZnF_C2H2

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

1.30e-03808296SM00355
Domainzf-C2H2_6

ZNF267 ZNF14 PEG3

1.24e-02314293PF13912
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1S

4.87e-086203M47762
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1D CACNA1S

8.80e-0714203M47692
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

CACNA1C CACNA1D CACNA1S DSP

3.18e-0674204M39462
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

CACNA1C CACNA1D CACNA1S DSP

3.18e-0674204M16376
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1S

4.25e-0623203M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1D CACNA1S

5.51e-0625203M47948
PathwayREACTOME_NCAM1_INTERACTIONS

CACNA1C CACNA1D CACNA1S

2.71e-0542203M7169
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1C CACNA1D CACNA1S CHRM3

4.83e-05147204MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1C CACNA1D CACNA1S CHRM3

5.36e-05151204M39329
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

CACNA1C CACNA1D CACNA1S

9.19e-0563203M11187
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1C CACNA1D CACNA1S CHRM3

1.02e-04178204M2890
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1C CACNA1S

1.04e-0411202M47958
PathwayWP_ALZHEIMERS_DISEASE

CACNA1C CACNA1D CACNA1S

1.48e-0474203MM15962
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1C CACNA1D CHRM3

1.74e-0478203M1921
PathwayKEGG_CARDIAC_MUSCLE_CONTRACTION

CACNA1C CACNA1D CACNA1S

1.80e-0479203M17673
PathwayKEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM

CACNA1C CACNA1D CACNA1S

2.09e-0483203M8728
PathwayKEGG_DILATED_CARDIOMYOPATHY

CACNA1C CACNA1D CACNA1S

2.65e-0490203M835
PathwayKEGG_GNRH_SIGNALING_PATHWAY

CACNA1C CACNA1D CACNA1S

3.72e-04101203M1979
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1C CACNA1D CHRM3

4.53e-04108203M17034
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

CACNA1C CACNA1D CACNA1S

5.45e-04115203M9387
PathwayREACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION

CACNA1C CACNA1D

7.07e-0428202M10679
PathwayKEGG_ALZHEIMERS_DISEASE

CACNA1C CACNA1D CACNA1S

1.58e-03166203M16024
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1C CACNA1D

1.99e-0347202M19708
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1C CACNA1D

3.33e-0361202MM15071
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1C CACNA1D

4.61e-0372202MM14631
PathwayWP_MAPK_SIGNALING

CACNA1C CACNA1D CACNA1S

4.80e-03246203M39597
PathwayWP_JOUBERT_SYNDROME

PIBF1 MYO5A

5.12e-0376202M39835
PathwayWP_ALZHEIMERS_DISEASE

CACNA1C CACNA1D CACNA1S

5.66e-03261203M42565
PathwayKEGG_MAPK_SIGNALING_PATHWAY

CACNA1C CACNA1D CACNA1S

6.03e-03267203M10792
Pubmed

Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.

CACNA1C CACNA1D CACNA1S

5.79e-10330317289261
Pubmed

Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).

CACNA1C CACNA1D CACNA1S

5.79e-10330317767505
Pubmed

Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.

CACNA1C CACNA1D CACNA1S

5.79e-1033032173707
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1D CACNA1S

2.32e-09430320937870
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1D CACNA1S

2.02e-08730312900400
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1C CACNA1D CACNA1S

2.62e-071530320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1C CACNA1D CACNA1S

2.62e-071530324453333
Pubmed

Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.

CACNA1C CACNA1D

7.19e-07230224849370
Pubmed

Temporal expression of calcium channel subunits in satellite cells and bone marrow mesenchymal cells.

CACNA1C CACNA1S

7.19e-07230225277766
Pubmed

Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.

CACNA1C CACNA1D

7.19e-07230220014384
Pubmed

Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.

CACNA1C CACNA1D

7.19e-07230226049024
Pubmed

Endogenous cardiac Ca2+ channels do not overcome the E-C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link.

CACNA1C CACNA1S

7.19e-0723027635187
Pubmed

Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.

CACNA1C CACNA1D

7.19e-07230217015854
Pubmed

Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.

CACNA1C CACNA1D

7.19e-07230230001160
Pubmed

Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.

CACNA1C CACNA1D

7.19e-07230219225208
Pubmed

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.

CACNA1C CACNA1D

7.19e-07230216706838
Pubmed

[The expression of genes encoding the voltage-dependent L-type Ca2+ channels in proliferating and differentiating C2C12 myoblasts of mice].

CACNA1D CACNA1S

7.19e-07230221789999
Pubmed

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.

CACNA1C CACNA1D

7.19e-07230223761887
Pubmed

Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

CACNA1C CACNA1D

7.19e-07230214981074
Pubmed

Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.

CACNA1C CACNA1D

7.19e-07230221352396
Pubmed

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

CACNA1C CACNA1D

7.19e-07230225292336
Pubmed

A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice.

CACNA1C CACNA1S

7.19e-0723021281468
Pubmed

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

CACNA1C CACNA1D

7.19e-07230217526649
Pubmed

Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.

CACNA1D CACNA1S

7.19e-07230228978442
Pubmed

Ligand-activated signal transduction in the 2-cell embryo.

CACNA1C CACNA1D

7.19e-07230212606379
Pubmed

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

CACNA1C CACNA1D

7.19e-07230224941892
Pubmed

Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.

CACNA1C CACNA1D

7.19e-07230221054386
Pubmed

Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.

CACNA1C CACNA1D

7.19e-07230217409250
Pubmed

Neuronal L-type calcium channels open quickly and are inhibited slowly.

CACNA1C CACNA1D

7.19e-07230216267232
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.

CACNA1C CACNA1D

7.19e-07230224848473
Pubmed

Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.

CACNA1C CACNA1D

7.19e-07230222826131
Pubmed

The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.

CACNA1C CACNA1D

7.19e-07230224996399
Pubmed

Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

CACNA1C CACNA1D

7.19e-07230224470632
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.

CACNA1C CACNA1D

7.19e-07230224760982
Pubmed

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

CACNA1C CACNA1D

7.19e-07230224086669
Pubmed

Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels.

CACNA1C CACNA1S

2.16e-0633029668070
Pubmed

The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.

CACNA1C CACNA1D

2.16e-06330219351867
Pubmed

Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.

CACNA1C CACNA1D

2.16e-06330221832054
Pubmed

Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.

CACNA1C CACNA1D

2.16e-06330223973784
Pubmed

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

CACNA1C CACNA1D

2.16e-06330226831068
Pubmed

MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels.

CACNA1C CACNA1D

2.16e-06330231302118
Pubmed

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.

CACNA1C CACNA1D

2.16e-06330223045342
Pubmed

Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.

CACNA1C CACNA1D

2.16e-06330223338940
Pubmed

Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.

CACNA1C CACNA1S

2.16e-06330211206130
Pubmed

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

CACNA1C CACNA1D

2.16e-06330224934288
Pubmed

mRNA for cardiac calcium channel is expressed during development of skeletal muscle.

CACNA1C CACNA1S

2.16e-0633028381753
Pubmed

Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.

CACNA1C CACNA1D

4.31e-06430217110593
Pubmed

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.

CACNA1C CACNA1D

7.18e-06530231663850
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1C CACNA1D

7.18e-06530211296258
Pubmed

The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1.

CACNA1C CACNA1S

7.18e-0653021335956
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1C CACNA1D

7.18e-06530215451373
Pubmed

Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.

CACNA1C CACNA1D

1.08e-05630216029198
Pubmed

Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.

CACNA1C CACNA1D

1.08e-05630221224388
Pubmed

L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.

CACNA1C CACNA1D

1.08e-05630223734214
Pubmed

Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.

CACNA1C CACNA1S

1.51e-0573029004034
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1D CACNA1S

2.01e-05830228330839
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ATXN10 TBC1D31 FCHO2 PIBF1 PTPRG MYO5A DSP

2.47e-05104930727880917
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1C CACNA1S

2.58e-05930216382099
Pubmed

Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.

CACNA1C CACNA1D CACNA1S

2.67e-056730316987237
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1C CACNA1D

3.94e-051130218809727
Pubmed

Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.

CACNA1C CACNA1S

8.57e-051630232994313
Pubmed

Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library.

USP45 PEG3

9.70e-05173027808216
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

CACNA1C CACNA1D

9.70e-051730227725084
Pubmed

Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.

CACNA1D LOXHD1

1.09e-041830233087486
Pubmed

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

ANKRD36B ANGPTL7 ZBTB21

1.41e-0411730312107410
Pubmed

Genome-wide association study identifies five new schizophrenia loci.

CACNA1C PTPRG

1.80e-042330221926974
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1C CACNA1D CACNA1S

2.34e-0413930316985003
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

CACNA1C CACNA1D CACNA1S

2.55e-0414330320424473
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CACNA1D CACNA1S

3.74e-043330222357600
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

TBC1D31 FCHO2 PIBF1

4.16e-0416930331462741
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

TBC1D31 PIBF1

4.96e-043830236674791
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1C CACNA1D

4.96e-043830230786075
Pubmed

Global landscape of HIV-human protein complexes.

FNIP1 ATXN10 ZNRD2 DSP

6.15e-0445730422190034
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

LOXHD1 CHRM3

6.65e-044430227534441
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

CACNA1C CACNA1D

6.96e-044530225979088
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

FCHO2 MYO5A ZNRD2 PEG3

7.45e-0448130428190767
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1D CACNA1S

5.95e-0626253253
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

RLF ZNF267 ZNF14 GTF3A PEG3 ZBTB21

3.56e-0471825628
CoexpressionCHEN_HOXA5_TARGETS_9HR_UP

RLF ZNF267 ZNF14 TBC1D31 PIBF1

5.11e-06223305M17621
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD36B CACNA1C CACNA1D CHRM3 PEG3

2.04e-071983050ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C THSD7A PTPRG CHRM3

8.08e-0619230427ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD36B CACNA1C CACNA1D CHRM3

8.76e-06196304676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1C CACNA1D CHRM3 PEG3

9.12e-061983046d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1C CACNA1D CHRM3 PEG3

9.12e-061983044ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

ANKRD36B IFIH1 ANKRD36C DSP

9.30e-06199304952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANKRD36B CACNA1C CACNA1D CHRM3

9.49e-0620030448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNRD2 DSP ZBTB21

1.86e-04166303c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCelldroplet-Liver-LIVER-30m-Myeloid-plasmacytoid_dendritic_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D MYO5A ANGPTL7

2.07e-0417230324ecfda5e43e28f190089770cd2eae5bf2ed292b
ToppCelldroplet-Liver-LIVER-30m-Myeloid-plasmacytoid_dendritic_cells|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D MYO5A ANGPTL7

2.07e-04172303db5a31cafce4346fe459d7f35210823fd7004439
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCHO2 PIBF1 PEG3

2.21e-04176303749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C CACNA1D PEG3

2.29e-04178303fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANKRD36B ANKRD36C DSP

2.32e-041793036e965e424eebef50f0202cff75f458be395cfca1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LOXHD1 THSD7A SYCP1

2.32e-0417930301302505816f272243659e20d751b61a198a2fc0
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C CACNA1D PEG3

2.40e-041813039e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellRA-07._Pericyte|RA / Chamber and Cluster_Paper

CACNA1C THSD7A CHRM3

2.40e-041813038dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCellRA-07._Pericyte|World / Chamber and Cluster_Paper

CACNA1C THSD7A CHRM3

2.44e-041823032075efeae633550fb2eb026d0dfd741c8252482e
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FNIP1 DSP THAP1

2.48e-041833036e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C THSD7A PTPRG

2.48e-04183303ff95382cfed592190d0636d2b750328471f82e0d
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1D THSD7A ANGPTL7

2.48e-04183303dc9602bed3136db91faeffef177006246dc92743
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DSP CHRM3 PEG3

2.60e-041863031587667e5084ac43505d027af925ba711e228150
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.64e-04187303e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.64e-0418730386250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

CACNA1C CACNA1D PTPRG

2.64e-0418730392d468dde81125d51daf7abd4703741abe1ab91c
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

CACNA1D PTPRG CHRM3

2.68e-04188303ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellhuman_hepatoblastoma-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

LOXHD1 THSD7A MYO5A

2.77e-041903038d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

CACNA1C CACNA1D PTPRG

2.77e-041903033a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C CACNA1D PEG3

2.77e-04190303d60395739458d7f47a3350ade751fe3819500320
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C CACNA1D PEG3

2.81e-0419130314057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C CACNA1D PTPRG

2.81e-041913036688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C CACNA1D PTPRG

2.85e-0419230399ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRG CHRM3 PEG3

2.85e-041923031ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.90e-04193303acad568621ed677031797b8c2e34dafea798d681
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF14 ANKRD36C THSD7A

2.90e-041933039337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.90e-0419330399525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.90e-04193303b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

CACNA1C CACNA1D PTPRG

2.90e-04193303e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.94e-04194303e93de9428c986b8943fc169258847c650cfab0e5
ToppCellControl-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

CACNA1C CACNA1D PTPRG

2.94e-041943033c2266772c5b56e8e02a461e5193e29588028ee9
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

2.94e-04194303011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CACNA1D THSD7A PTPRG

2.94e-04194303b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANKRD36B ZNF14 THAP1

2.99e-0419530383c125223e7ca0f08a31414b3a16347912564765
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

CACNA1C CACNA1D PTPRG

2.99e-04195303603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

ZNF267 IFIH1 DSP

2.99e-04195303b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A PTPRG CHRM3

2.99e-04195303d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D FNIP1 PEG3

2.99e-041953033e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D FNIP1 PEG3

2.99e-041953037796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CACNA1D THSD7A PTPRG

2.99e-041953030e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

3.03e-04196303bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATXN10 THSD7A DSP

3.03e-04196303547901c7a665770eff78eede69b8625b416c8186
ToppCellfacs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C ANGPTL7 PEG3

3.03e-0419630390edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCellPCW_07-8.5-Mesenchymal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CACNA1C CACNA1D PTPRG

3.03e-041963038e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATXN10 THSD7A DSP

3.03e-041963036e08d7ba67da161c2dca1a17c440ffb9d9b5bc3b
ToppCellfacs-Skin-Telogen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C ANGPTL7 PEG3

3.03e-04196303c936014125b2ed5f796221b74acb77b8f8359875
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C CACNA1D PTPRG

3.03e-041963037d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF14 ANKRD36C THSD7A

3.08e-0419730357ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellBronchus_Control_(B.)|World / Sample group, Lineage and Cell type

ZNF267 ANKRD36C DSP

3.08e-04197303b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CACNA1C CACNA1D THSD7A

3.08e-041973030034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CACNA1C CACNA1D PTPRG

3.08e-0419730373a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CACNA1C CACNA1D THSD7A

3.08e-0419730311a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellwk_08-11-Epithelial-Distal_epithelial_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MYO5A DSP PEG3

3.12e-04198303eda85a592527992b51a00f288cff0c3239c47e6f
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

CACNA1C CACNA1D PTPRG

3.12e-04198303df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1C CACNA1D CHRM3

3.12e-04198303c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1C CACNA1D PTPRG

3.12e-041983038f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1C CHRM3 PEG3

3.12e-041983038ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellwk_08-11-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MYO5A DSP PEG3

3.12e-0419830384697f316d9195ebe838cf57f4dbdd9feea43bec
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CACNA1C CACNA1D THSD7A

3.12e-0419830317dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellBronchus_Control_(B.)-Stromal-TX-Mesothelial-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CACNA1C ANGPTL7 PEG3

3.12e-041983039b1a58fcf818f9c4ae57bbe99655f0a64fe87df7
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

3.12e-0419830321cf4d81386761d09d0f6829c01c198e5524176d
ToppCellPCW_10-12-Mesenchymal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CACNA1C CACNA1D PTPRG

3.17e-04199303a09292de4c4447b8eee55d401808e43b817321cc
ToppCellMesenchymal|World / Lineage, Cell type, age group and donor

CACNA1C CACNA1D PTPRG

3.17e-041993034bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD36C THSD7A DSP

3.22e-04200303f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD36C THSD7A DSP

3.22e-042003031639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

ANKRD36C DSP CHRM3

3.22e-04200303682960e28542a3d6c119047cd0131941932cfdea
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD36C THSD7A DSP

3.22e-0420030370a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THSD7A PTPRG CHRM3

3.22e-04200303b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD7A PTPRG CHRM3

3.22e-0420030377ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

THSD7A PTPRG CHRM3

3.22e-0420030365b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

THSD7A PTPRG CHRM3

3.22e-04200303ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal|6m / Sample Type, Dataset, Time_group, and Cell type.

CACNA1S DSP DYDC2

3.22e-0420030313ec8afea86e4a10599c924871ba4e325b0a8013
DrugNilvadipine

CACNA1C CACNA1D CACNA1S

2.06e-085303DB06712
DrugNisoldipine

CACNA1C CACNA1D CACNA1S

2.06e-085303DB00401
DrugCPU-23

CACNA1C CACNA1D CACNA1S

4.12e-086303CID003036051
DrugAmlodipine

CACNA1C CACNA1D CACNA1S

7.20e-087303DB00381
DrugIsradipine

CACNA1C CACNA1D CACNA1S

7.20e-087303DB00270
DrugNitrendipine

CACNA1C CACNA1D CACNA1S

1.15e-078303DB01054
DrugNifedipine

CACNA1C CACNA1D CACNA1S

1.15e-078303DB01115
DrugCinnarizine

CACNA1C CACNA1D CACNA1S

1.72e-079303DB00568
DrugNimodipine

CACNA1C CACNA1D CACNA1S

1.72e-079303DB00393
DrugFelodipine

CACNA1C CACNA1D CACNA1S

3.38e-0711303DB01023
DrugMibefradil

CACNA1C CACNA1D CACNA1S

3.38e-0711303DB01388
DrugAC1L1JG6

CACNA1C CACNA1D CACNA1S

7.44e-0714303CID000005026
DrugNicardipine

CACNA1C CACNA1D CHRM3

7.44e-0714303DB00622
DrugFPL 64176

CACNA1C CACNA1D CACNA1S

9.29e-0715303CID000003423
DrugVerapamil

CACNA1C CACNA1D CACNA1S

1.14e-0616303DB00661
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1C CACNA1D CACNA1S PIBF1

3.43e-0679304CID005287890
DrugNSC-686960

CACNA1C CACNA1D

1.01e-054302CID000192816
DrugCNS 1145

CACNA1C CACNA1D CACNA1S

1.10e-0533303CID000190902
DrugIHC-64

CACNA1C CACNA1D CACNA1S

1.10e-0533303CID000162753
Drugmethyl beta-aminocrotonate

CACNA1C CACNA1D

1.67e-055302CID000084253
Drugnemadipine-A

CACNA1C CACNA1D

1.67e-055302CID002856102
DrugB 874-67

CACNA1C CACNA1D

1.67e-055302CID000195466
Drugpimozide

CACNA1C CACNA1D CACNA1S CHRM3

2.26e-05127304CID000016362
DrugMagnesium Sulfate

CACNA1C CACNA1S

2.51e-056302DB00653
Drugh PM

CACNA1C CACNA1D CACNA1S

2.82e-0545303CID005494424
DrugKW-3049

CACNA1C CACNA1D CACNA1S

3.88e-0550303CID000002324
Drug1,5-benzothiazepin-4(5H)-one

CACNA1C CACNA1D

4.68e-058302CID000358939
DrugCinildipine

CACNA1C CACNA1D CACNA1S

5.46e-0556303CID000002752
Drugnilvadipine

CACNA1C CACNA1D CACNA1S

6.71e-0560303CID000004494
DrugIAA-94

CACNA1C CACNA1D CACNA1S

7.06e-0561303CID000003667
DrugAC1L3TPS

CACNA1C CACNA1D

7.50e-0510302CID000121952
Druglercanidipine

CACNA1C CACNA1D CACNA1S

7.77e-0563303CID000065866
DrugNSC759256

CACNA1C CACNA1D CACNA1S

7.77e-0563303CID000125889
Drugmibefradil

CACNA1C CACNA1D CACNA1S

8.15e-0564303CID000060662
Druggallopamil

CACNA1C CACNA1D CACNA1S

9.34e-0567303CID000001234
DrugAC1L2AC7

CACNA1C CACNA1D CACNA1S

1.02e-0469303CID000068733
DrugAC1L1JVU

CACNA1C CACNA1D CACNA1S

1.16e-0472303CID000005229
DrugCAS 298-57-7

CACNA1C CACNA1D CACNA1S

1.21e-0473303CID000002761
Drugethosuximide

CACNA1C CACNA1D CACNA1S

1.26e-0474303CID000003291
Drugnisoldipine

CACNA1C CACNA1D CACNA1S

1.47e-0478303CID000004499
Drugpinaverium bromide

CACNA1C CACNA1D

1.51e-0414302CID000040703
Drugfendiline

CACNA1C CACNA1D

1.99e-0416302CID000003336
Drugefonidipine

CACNA1C CACNA1D

2.25e-0417302CID000119170
DrugAC1NUZ8M

CACNA1C CACNA1D CACNA1S

2.40e-0492303CID000073211
Drugmanidipine

CACNA1C CACNA1D CACNA1S

2.63e-0495303CID000004008
Drugisotetrandrine

CACNA1C CACNA1D CACNA1S

2.80e-0497303CID000005422
Drugnitrendipine

CACNA1C CACNA1D CACNA1S

2.89e-0498303CID000004507
Drugisradipine

CACNA1C CACNA1D CACNA1S

3.06e-04100303CID000003784
Drugclevidipine

CACNA1C CACNA1D

3.14e-0420302CID000153994
Drugloperamide

CACNA1C CACNA1D CACNA1S

3.53e-04105303CID000003954
Drugpyraclofos

CACNA1C CACNA1D CACNA1S

3.63e-04106303CID000093460
Drugverapamil

CACNA1C CACNA1D CACNA1S GTF3A MYO5A

4.13e-04490305CID000002520
DrugYM-09730-5

CACNA1C CACNA1D

4.17e-0423302CID000002296
Druglamotrigine

CACNA1C CACNA1D CACNA1S

4.73e-04116303CID000003878
DrugAC1NBU2S

CACNA1C CACNA1D CACNA1S

4.85e-04117303CID004473765
DrugMgSO4.7H2O

CACNA1C CACNA1S

4.94e-0425302CID000024843
Drugfluo-3

CACNA1C CACNA1D CACNA1S

5.48e-04122303CID000104978
Drugbepridil

CACNA1C CACNA1D CACNA1S

6.02e-04126303CID000002351
Drugamlodipine

CACNA1C CACNA1D CACNA1S

6.02e-04126303CID000002162
DrugNCDC

CACNA1C CACNA1D

6.21e-0428302CID000001583
Drugclobazam

CACNA1C CACNA1D

6.67e-0429302CID000002789
DrugBarium permanganate

CACNA1C CACNA1D CACNA1S

7.05e-04133303CID000024587
Druglanthanum

CACNA1C CACNA1D CACNA1S

7.52e-04136303CID000023926
DrugK-Cl

IFIH1 CACNA1C CACNA1D CACNA1S MYO5A

8.01e-04567305CID000004873
Drugremifentanil

CACNA1C CACNA1D

8.12e-0432302CID000060814
Drugisovalerate

CACNA1C CACNA1D CACNA1S

8.70e-04143303CID000010430
DrugDantrolene-13C3

CACNA1C CACNA1D CACNA1S

9.06e-04145303CID000002951
Drugnimodipine

CACNA1C CACNA1D CACNA1S

9.06e-04145303CID000004497
Drugnicardipine

CACNA1C CACNA1D CACNA1S

9.06e-04145303CID000004473
DrugBay K 8644

CACNA1C CACNA1D CACNA1S

9.99e-04150303CID000002303
Drugprocaine

CACNA1C CACNA1D CACNA1S

1.06e-03153303CID000004914
Druglindane

CACNA1C CACNA1D CACNA1S

1.08e-03154303CID000000727
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D CACNA1S

3.41e-094293DOID:0060173 (implicated_via_orthology)
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1D CACNA1S

5.96e-0636293DOID:11723 (implicated_via_orthology)
DiseaseSudden Cardiac Death

CACNA1C DSP

2.60e-058292C0085298
DiseaseManic Disorder

CACNA1C CACNA1D THSD7A

4.66e-0571293C0024713
Diseaseextrapulmonary tuberculosis

CACNA1C THSD7A

6.12e-0512292MONDO_0000368
DiseaseManic

CACNA1C CACNA1D THSD7A

6.18e-0578293C0338831
DiseaseDepression, Bipolar

CACNA1C CACNA1D THSD7A

6.42e-0579293C0005587
Diseaseinsular cortex volume measurement

LOXHD1 THSD7A

2.33e-0423292EFO_0010309
Diseaseresting heart rate

CACNA1C CACNA1D DSP

4.19e-04149293EFO_0004351
Diseasepyridoxate measurement

CACNA1D CHRM3

4.26e-0431292EFO_0010527
Diseasemajor depressive episode, major depressive disorder

CACNA1C THSD7A

5.44e-0435292EFO_0007634, MONDO_0002009
Diseaseprimary immunodeficiency disease (is_implicated_in)

IFIH1 FNIP1

7.84e-0442292DOID:612 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ECFSAQKECNKEKNR

PTPRG

1166

P23470
LCYKNKDNQDKVNEL

ATXN10

381

Q9UBB4
ENYNAKCVEQERLKK

FCHO2

141

Q0JRZ9
CQCDKKKRRKQQYQQ

CHRM3

561

P20309
CIEKQERFCQLKKQN

ANKRD36B

1151

Q8N2N9
KDNDNCLDKCAQLRK

ANGPTL7

276

O43827
CIEKQERFCQLKKQN

ANKRD36C

1576

Q5JPF3
QEEYQIQQNCEKCHK

DYDC2

76

Q96IM9
CTQQKYLCTNKREQK

LOXHD1

1131

Q8IVV2
QEQYAKEQARNKCKD

PEG3

1021

Q9GZU2
EYKNCELDKNQRQCV

CACNA1C

1196

Q13936
YKNCELDKNQRQCVQ

CACNA1S

1076

Q13698
KNNKQNNEFCKCIET

FNIP1

876

Q8TF40
KNDYDQLQKARQCEK

DSP

1136

P15924
VRENKALQKKCADYQ

IFIH1

941

Q9BYX4
KEYKNCELDKNQRQC

CACNA1D

1161

Q01668
DVCTKDRQCQDNKKC

EPPIN

46

O95925
QKCDDLQRNKCYQEV

TBC1D31

906

Q96DN5
NAVEKEPCNLNKNCY

THSD7A

1206

Q9UPZ6
VENKEVYQCRLCNAK

ZBTB21

716

Q9ULJ3
CENCTKNKQKYQEET

USP45

641

Q70EL2
QYNKEQLCLEKDKAR

RLF

1336

Q13129
KCKLDKSEENCNNLR

SYCP1

591

Q15431
EKQEQSYKCNKCVEV

ZNF267

261

Q14586
DCFKRECNNKLLKEN

THAP1

61

Q9NVV9
LTQCQLECEKYQKKL

PIBF1

481

Q8WXW3
LQDKQRKIYCVACQE

ZNRD2

61

O60232
ENQQKQYICSFEDCK

GTF3A

126

Q92664
NEYQEYEKQPCKCKA

ZNF14

131

P17017
QLQRKVDEQNKDYKC

MYO5A

931

Q9Y4I1