Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZBTB16 MAX ZNF699 PRDM5 THAP1 CASZ1 ZNF181 RLF ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 TBX10 ZBTB11 ZNF844 PRDM15 ZNF614 TBX2

6.45e-06141210121GO:0000981
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZBTB16 MAX ZNF699 PRDM5 THAP1 ZBTB32 GZF1 ZNF844 TBX2

3.57e-053201019GO:0001227
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZBTB16 MAX ZNF699 PRDM5 THAP1 CASZ1 ZNF181 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 TBX10 ZBTB11 ZNF844 PRDM15 ZNF614 TBX2

3.62e-05145910120GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZBTB16 MAX ZNF699 PRDM5 THAP1 ZBTB32 GZF1 ZNF844 TBX2

4.13e-053261019GO:0001217
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK2 GRK3

1.51e-0441012GO:0047696
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZBTB16 MAX ZNF699 PRDM5 THAP1 ZNF181 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 GLIS2 TBX10 ZBTB11 ZNF844 PRDM15 TBX2

1.58e-04124410117GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZBTB16 MAX ZNF699 PRDM5 THAP1 ZNF181 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 GLIS2 TBX10 ZBTB11 ZNF844 PRDM15 TBX2

2.04e-04127110117GO:0000987
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK2 GRK3

5.23e-0471012GO:0004703
MousePhenoincreased circulating total protein level

ITCH DSG1 PITPNC1 DDX6 KCNH6 DNAH5

2.24e-05108746MP:0005568
Domainzf-C2H2

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

2.15e-086939918PF00096
Domain-

ZBTB16 ZNF699 PRDM5 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

9.48e-0867999173.30.160.60
DomainZINC_FINGER_C2H2_2

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

1.17e-077759918PS50157
DomainZINC_FINGER_C2H2_1

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

1.21e-077779918PS00028
DomainZnf_C2H2/integrase_DNA-bd

ZBTB16 ZNF699 PRDM5 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

1.29e-076949917IPR013087
DomainZnf_C2H2-like

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

1.74e-077969918IPR015880
DomainZnf_C2H2

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

2.05e-078059918IPR007087
DomainZnF_C2H2

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

2.17e-078089918SM00355
Domainzf-C2H2_6

ZBTB16 ZNF699 PRDM5 ZNF181 ZNF12 ZNF16 ZNF526 GZF1 ZNF684 ZBTB11 ZNF844

8.62e-073149911PF13912
DomainGPCR_kinase

GRK2 GRK3

5.74e-047992IPR000239
DomainPTEN_C2

GAK TPTE2

7.63e-048992SM01326
DomainPTEN_C2

GAK TPTE2

7.63e-048992PF10409
DomainC2_TENSIN

GAK TPTE2

7.63e-048992PS51182
DomainTensin_lipid_phosphatase_dom

GAK TPTE2

7.63e-048992IPR029023
DomainTensin_C2-dom

GAK TPTE2

7.63e-048992IPR014020
DomainRGS

GRK2 GRK3 SNX25

8.36e-0435993PF00615
DomainRGS

GRK2 GRK3 SNX25

8.36e-0435993SM00315
DomainRGS

GRK2 GRK3 SNX25

9.08e-0436993PS50132
DomainPPASE_TENSIN

GAK TPTE2

9.77e-049992PS51181
DomainRGS

GRK2 GRK3 SNX25

1.15e-0339993IPR016137
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

FUT10 MBTPS1 ITCH ZBTB16 RTEL1 SLC38A9 PLD3 CASZ1 RLF ZNF462 FAM111A GRK3 RABEP1 SPIDR USP15 PRDM15 TMEM181 NCK2 HTT

5.12e-0814891011928611215
Pubmed

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.

GRK2 GRK3 DNTT

2.81e-061010131869533
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

8.35e-06210128638670
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

8.35e-062101233060647
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

8.35e-06210128035170
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

8.35e-062101210198406
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

8.35e-062101211762794
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RTEL1 PPFIA4 CEP290 CASZ1 ZNF462 ZNF526 CEP152 SPIDR PDZRN4

1.42e-05493101915368895
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

AKAP6 ITCH ZBTB16 SYNE1 SAMHD1 ZNF181 ZNF462 RABEP1 MYOM2

1.51e-05497101923414517
Pubmed

Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

GRK2 GRK3

2.50e-053101210754297
Pubmed

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

GRK2 GRK3

2.50e-053101210085131
Pubmed

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

GRK2 GRK3

2.50e-05310127761854
Pubmed

A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.

ZBTB16 ZBTB32

2.50e-053101210572087
Pubmed

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.

GRK2 GRK3

2.50e-053101231604529
Pubmed

Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.

ZBTB16 ZBTB32

2.50e-053101211964310
Pubmed

Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins.

ITCH HTT

2.50e-053101224865853
Pubmed

Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

GRK2 GRK3

2.50e-053101212130708
Pubmed

Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.

UGT2A3 UGT2A1

2.50e-053101219858781
Pubmed

Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin.

GRK2 HTT

4.99e-054101216091361
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK2 GRK3

4.99e-054101221784156
Pubmed

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

GRK2 GRK3

4.99e-05410128917529
Pubmed

Mammalian microtubule P-body dynamics are mediated by nesprin-1.

SYNE1 DDX6

4.99e-054101224862572
Pubmed

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.

MBTPS1 SEC23A

4.99e-054101234349020
Pubmed

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

GRK2 GRK3

4.99e-05410128662816
Pubmed

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.

GRK2 GRK3

4.99e-054101223734232
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

TRPC4 ITPR3

4.99e-054101211163362
Pubmed

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells.

ITCH PRMT1

4.99e-054101230736843
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

ITCH ZBTB16 ZBTB32 USP15 PDZRN4

5.34e-05138101528786561
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

GTPBP4 MAX CASZ1 GTF3C3 RLF ZNF462 ZNF12 ZBTB11 PRDM15

7.20e-05608101936089195
Pubmed

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

GRK2 GRK3

8.30e-055101210338466
Pubmed

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

CAPN5 HTT

8.30e-055101214981075
Pubmed

VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression.

ZBTB16 ZBTB32

8.30e-055101212821938
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GTPBP4 ITCH SYNE1 TRPC4 GRIN2D TWF1 ZNF462 CNTNAP5 RABEP1 PRMT1 SEC23A

1.14e-049631011128671696
Pubmed

The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.

GRK2 GRK3 PRMT1 USP15

1.19e-0486101426885983
Pubmed

The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels.

ITCH TRPC4

1.24e-046101217110928
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK2 GRK3

1.24e-04610129826657
Pubmed

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.

TRPC4 ITPR3

1.24e-046101217416589
Pubmed

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.

GRK2 GRK3

1.24e-046101220074556
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK2 GRK3

1.24e-046101236451830
Pubmed

Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.

UMODL1 PRDM15

1.74e-047101211528125
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK2 GRK3

1.74e-04710128672451
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK2 GRK3

1.74e-047101211517230
Pubmed

Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development.

NPY2R TRPC4

1.74e-047101210556287
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF699 ZNF181 ZNF684 ZBTB11 ZNF614

1.91e-04181101537372979
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

USP13 DSG1 JAGN1 CASZ1 GTF3C3 RLF ZNF462 ZNF12 ZNF16 BCAP31 GZF1 FAM111A

1.95e-0412031011229180619
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

NPY2R TRPC4 GRK2 GRK3 HCRTR2

1.96e-04182101520468064
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

GAK ASPM SEC23A NCK2 HTT

2.17e-04186101533637726
Pubmed

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.

GTPBP4 DPH1 ASPM

2.17e-0440101320308539
Pubmed

Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER.

RABEP1 RAB33B

2.31e-048101211718716
Pubmed

A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.

TBX10 TBX2

2.31e-04810129503012
Pubmed

Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.

GRK2 GRK3

2.97e-049101234873237
Pubmed

Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.

TRPC4 ITPR3

2.97e-049101211290752
Pubmed

The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.

ZNF699 RABEP1 MYOM2

3.97e-0449101332918875
Pubmed

Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.

CEP290 ZNF462 HTT

4.22e-0450101323272104
Pubmed

Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.

HS3ST1 HS6ST3

4.51e-0411101215944372
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

GTPBP4 RTEL1 ZNF462 POLQ SEC23A

4.88e-04222101537071664
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AKAP6 RTEL1 SYNE1 ZNF462 USP15

5.19e-04225101512168954
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

GTPBP4 SYNE1 SNX25 ASPM DNAH5

6.19e-04234101536243803
Pubmed

Yeast two-hybrid screens implicate DISC1 in brain development and function.

PPFIA4 CEP290

6.38e-0413101214623284
Pubmed

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

ITCH USP15

6.38e-0413101223146885
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

GTPBP4 DDX6 TRMT2A ASPM PRMT1 ZBTB11

6.94e-04364101624778252
Pubmed

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

SYNE1 RABEP1 CEP152

7.21e-0460101320682791
Pubmed

ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.

ZBTB32 GZF1 ZBTB11

8.32e-0463101334351428
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP13 USP15

8.55e-041510129827704
Pubmed

Common body mass index-associated variants confer risk of extreme obesity.

ITPR3 PRF1

8.55e-0415101219553259
Pubmed

Common genetic variants associate with serum phosphorus concentration.

ITPR3 PDE7B

8.55e-0415101220558539
Pubmed

Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.

DDX6 PRMT1

8.55e-0415101229510985
Pubmed

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.

GTPBP4 ITCH GTF3C3

9.11e-0465101329378950
Pubmed

Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

ASPM CEP152

9.76e-0416101220301772
Pubmed

The Genetic Basis of Baculum Size and Shape Variation in Mice.

ASPM SEC23A

9.76e-0416101226935419
Pubmed

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

DPH1 RTEL1 TRMT2A USPL1

9.81e-04150101422678362
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

RTEL1 SYNE1 DDX6 HTT

1.03e-03152101434299191
Pubmed

O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.

DSG1 SAMHD1

1.10e-0317101227217568
Pubmed

Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.

MAX PRMT1

1.10e-0317101221653943
Pubmed

Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.

SYNE1 CNTNAP5

1.10e-0317101217903302
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

DSG1 SAMHD1 GTF3C3 DDX6 SEC23A RAB33B

1.13e-03400101635013556
Pubmed

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.

CEP290 GLIS2

1.24e-0318101221068128
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 USP13 ITCH SYNE1 CEP290 WHAMM ZNF181 RABEP1 USPL1 ZBTB11 RSBN1L

1.28e-0312851011135914814
Pubmed

An investigation into the human serum "interactome".

GDF10 RLF PDZRN4 DNTT

1.30e-03162101415174051
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

FUT10 TPTE2 KCNH6 PRMT1 CAPN5 USP15 DNAH5 SEC23A

1.32e-03730101834857952
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

MAX RLF ZNF462

1.33e-0374101329795351
Pubmed

Proteomics characterization of abundant Golgi membrane proteins.

BCAP31 SEC23A

1.38e-0319101211042173
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

FUT10 SLC38A9 PRDM5 TWF1 ZNF16 GZF1 SNX25 HS6ST3 TBX2

1.40e-03915101932393512
Pubmed

The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.

SAMHD1 TWF1 GRK2

1.43e-0376101323940030
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

GTPBP4 ITCH SAMHD1 TRMT2A CEP152

1.44e-03283101521903422
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

ITPR3 TRMT2A RABEP1 HS6ST3 HTT

1.49e-03285101532838362
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

GTPBP4 ITCH MAX PRDM5 ZNF526 TRMT2A SUPT7L ASPM RSBN1L TBX2

1.53e-0311161011031753913
Pubmed

Evolutionary breakpoints on human chromosome 21.

UMODL1 PRDM15

1.53e-0320101211707078
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

ITCH PRMT1

1.69e-0321101237422473
Pubmed

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

ITCH PLD3

1.69e-0321101229416926
Pubmed

Nephronophthisis-Related Ciliopathies

CEP290 GLIS2

1.69e-0321101227336129
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

ITCH JAGN1 SAMHD1 PLD3 GTF3C3 ITPR3 BCAP31 RABEP1 SEC23A

1.71e-03942101931073040
Pubmed

Hereditary Dystonia Overview

SAMHD1 THAP1 HTT

1.78e-0382101320301334
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

GTPBP4 GTF3C3 DDX6 ITPR3 ZBTB11 USP15

1.83e-03440101634244565
Pubmed

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.

MBTPS1 SEC23A

1.86e-0322101225147951
Pubmed

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

PRDM5 PRDM15

1.86e-0322101219050759
Pubmed

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

ITCH USP15

1.86e-0322101224850914
Pubmed

Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.

HS3ST1 HTT

2.03e-0323101211597144
Pubmed

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

GTF3C3 DDX6 TRMT2A

2.11e-0387101333711283
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

GTPBP4 DSG1 SAMHD1 PLD3 GTF3C3 DDX6 GZF1 FAM111A PRMT1 RSBN1L SEC23A

2.13e-0313711011136244648
InteractionTRPC4 interactions

USP13 ITCH TRPC4 ITPR3

4.89e-06231014int:TRPC4
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZBTB16 ZNF699 PRDM5 CASZ1 ZNF181 RLF ZNF462 ZNF12 ZNF16 ZNF526 ZBTB32 GZF1 ZNF684 GLIS2 ZBTB11 ZNF844 PRDM15 ZNF614

1.11e-09718781828
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ITCH PRF1 CAPN5

4.98e-0436783823
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

GAK TPTE2

5.06e-048782837
GeneFamilyUbiquitin specific peptidases

USP13 USPL1 USP15

1.82e-0356783366
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM5 PRDM15

2.40e-03177821197
GeneFamilyT-boxes

TBX10 TBX2

2.69e-0318782766
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB16 ZBTB32 GZF1 ZBTB11

2.69e-03134784861
GeneFamilyDNA polymerases

POLQ DNTT

4.38e-0323782535
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PPFIA4 TRPC4 PITPNC1 MYOM2 HS6ST3 TBX2 PDZRN4

8.55e-091791028111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCellAdult-Mesenchymal-myofibroblast_cell-D122|Adult / Lineage, Cell type, age group and donor

ZBTB16 TPTE2 IL1RAPL1 POLQ HS6ST3 TBX2

1.74e-061581026410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

AKAP6 NAALAD2 IL1RAPL1 MYOM2 TBX2 PDZRN4

1.87e-061601026fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZBTB16 TRPC4 SAMHD1 IL1RAPL1 PDE7B TBX2

2.57e-061691026c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB16 TRPC4 IL1RAPL1 HS6ST3 TBX2 PDZRN4

4.33e-06185102651dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB16 TRPC4 IL1RAPL1 HS6ST3 TBX2 PDZRN4

4.33e-061851026a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC4 IL1RAPL1 HS6ST3 NCK2 TBX2 PDZRN4

4.60e-061871026ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC4 IL1RAPL1 HS6ST3 NCK2 TBX2 PDZRN4

4.60e-061871026530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

SYNE1 PITPNC1 PRF1 SNX25 ASPM DNAH5

4.74e-061881026186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-gd_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZBTB16 SYNE1 NPDC1 PITPNC1 DDX6 PRF1

6.02e-061961026aec2b11a6048048820271266fdc8b8d806da9993
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-gd_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZBTB16 SYNE1 NPDC1 PITPNC1 DDX6 PRF1

6.02e-061961026aa0dc04f94a575cd442ee473b75a4f54268e4105
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-gd_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZBTB16 SYNE1 NPDC1 PITPNC1 DDX6 PRF1

6.02e-061961026502834a16d5ada93af7ab9af0c3dc652086964bd
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-gd_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZBTB16 SYNE1 NPDC1 PITPNC1 DDX6 PRF1

6.02e-061961026ae9bf04531b9bda819608d90736c4405a6c3df41
ToppCellControl-Lymphoid_T/NK-gd_T|Control / Disease group, lineage and cell class

ZBTB16 SYNE1 NPDC1 PITPNC1 DDX6 PRF1

6.02e-06196102698b11aada6bc5d928ef618573dc912d4d74a1092
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-gd_T|Influenza_Severe / Disease, condition lineage and cell class

SYNE1 PITPNC1 VN1R1 DDX6 PRF1 MYOM2

6.57e-061991026b1ecc8aa5a98fe42d678ab07b310d62ebaacdecf
ToppCellControl-Control-Lymphocyte-T/NK-gd_T|Control / Disease, condition lineage and cell class

ZBTB16 SYNE1 NPDC1 PITPNC1 DDX6 PRF1

6.76e-06200102688e502c141bbb73e62aa5830d24bd645376e5f3a
ToppCellLPS-antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

USP13 PPFIA4 GCGR STX19 ZNF684

2.47e-0515010259cb3332924bd67c966873343c14445e30d3f384f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 TRPC4 KCNH6 MYOM2 TBX2

3.90e-0516510259de841c1c95967c562720feba930246debc626fd
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 TRPC4 KCNH6 MYOM2 TBX2

3.90e-051651025a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 TRPC4 KCNH6 MYOM2 TBX2

3.90e-051651025cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCelldroplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHFPL4 PPFIA4 HS3ST1 RAB33B DNTT

4.13e-0516710251248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCelldroplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LHFPL4 PPFIA4 HS3ST1 RAB33B DNTT

4.13e-051671025a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND11 ZNF462 ASPM CEP152 POLQ

4.25e-051681025a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WHAMM SAMHD1 CASZ1 ITPR3 TRIM45

4.37e-0516910254e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCelldroplet-Thymus-nan-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAALAD2 PPFIA4 GCGR GDF10 GRK3

4.63e-05171102525493a4a7b636920e2cfd984542cc500709c9dcf
ToppCelldroplet-Thymus-nan-3m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAALAD2 PPFIA4 GCGR GDF10 GRK3

4.63e-051711025508b41e3ad2638f9dd546d251b13ff60fc8c3207
ToppCell3'_v3-GI_small-bowel-Lymphocytic_NK-NK_CD16|GI_small-bowel / Manually curated celltypes from each tissue

ZBTB16 SYNE1 CASZ1 PRF1 MYOM2

4.76e-051721025701de463f85aaad3a4b36a0d5fbc416406620089
ToppCelldroplet-Thymus-nan-3m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAALAD2 PPFIA4 GCGR GDF10 GRK3

4.89e-05173102563f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCellCOVID-19-kidney-REN+Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

PPFIA4 TRPC4 PITPNC1 PDE7B TBX2

5.02e-0517410258393f0b43c767839c1630bcb952d62b42efc788d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC4 IL1RAPL1 HS6ST3 TBX2 PDZRN4

5.45e-0517710254943d040eee0f9dceaddc7498171281d170e271f
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FUT10 CPZ PLD3 GDF10 ASPM

5.45e-0517710253e149bff1f1b393a7abe98984e37981c8296f95d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC4 IL1RAPL1 HS6ST3 TBX2 PDZRN4

5.45e-0517710253f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PITPNC1 TWF1 BCAP31 NCK2 TBX2

5.60e-05178102530d2b54462fd16222ad2e3806be6143e834b29e0
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 TRMT2A PRF1 NBEAL2 MYOM2

5.90e-051801025557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCellIIH-CD8-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

MBTPS1 SLC38A9 ZNF684 CEP152 USPL1

5.90e-051801025d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPY2R PITPNC1 ASPM NCK2 PDZRN4

6.22e-05182102572e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPY2R PITPNC1 ASPM NCK2 PDZRN4

6.22e-05182102505c167158815bf25d509df59ab386e1990712765
ToppCellCOVID-19_Mild-gd_T|COVID-19_Mild / Disease condition and Cell class

ITCH ZBTB16 SYNE1 PRF1 MYOM2

6.38e-051831025f593a89b0aa8fffdfa403769916facfd30358521
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP13 NAALAD2 TRPC4 GDF10 MYOM2

6.55e-0518410251c857126c0ea0671f0d60b048efca288d348d653
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC4 IL1RAPL1 HS6ST3 TBX2 PDZRN4

7.07e-05187102548bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

AKAP6 LRRC39 CASZ1 IL1RAPL1 MYOM2

7.07e-05187102578cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC4 IL1RAPL1 HS6ST3 TBX2 PDZRN4

7.07e-051871025958402fcc78f4c7a7d13d659d776f3817137975f
ToppCellCOPD-Lymphoid-NK|COPD / Disease state, Lineage and Cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

7.25e-051881025c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

AKAP6 LRRC39 USP13 IL1RAPL1 MYOM2

7.25e-0518810250758b474457efa36488e0195f7357100f4b6a090
ToppCellHealthy_donor-NK_CD56bright|Healthy_donor / disease group, cell group and cell class (v2)

ZBTB16 SYNE1 WHAMM PRF1 DNTT

7.43e-0518910259eac380a3bb4b685effb52d816e1960972660646
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

AKAP6 LRRC39 CASZ1 IL1RAPL1 MYOM2

7.43e-0518910259c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 IL1RAPL1 HCRTR2 TBX2 PDZRN4

7.43e-051891025975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCellCOPD-Lymphoid-NK|World / Disease state, Lineage and Cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

7.43e-051891025c0ac160fa7e68b92414fb1600abcac8ad1a42232
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 NAALAD2 ZBTB16 TBX2 PDZRN4

7.43e-051891025127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 NAALAD2 ZBTB16 TBX2 PDZRN4

7.43e-0518910252cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NPY2R LHFPL4 GCGR GRK3 HS6ST3

7.43e-051891025cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCellControl-Lymphoid-NK|Control / Disease state, Lineage and Cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

7.62e-051901025f7bd8521a40ac30a64dc439f17e2f6c7d021ef65
ToppCellCOVID-19-kidney-vSMC/Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

AKAP6 TRPC4 MYOM2 TBX2 PDZRN4

7.81e-051911025fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 LRRC39 USP13 MYOM2 PDZRN4

7.81e-051911025c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCellIPF-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

7.81e-051911025f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 LRRC39 USP13 MYOM2 PDZRN4

7.81e-051911025715f5b449b8e075959c05a5b38389df319663164
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 NPY2R GCGR CNTNAP5 HS6ST3

8.20e-0519310258851275bcf4ecd6e87a91c8784fc5d76d246ff3b
ToppCellCOPD-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

8.20e-0519310250020249fa71afb500af73700543bb6f349be6b10
ToppCell3'_v3-Lung-Lymphocytic_NK-NK_CD16|Lung / Manually curated celltypes from each tissue

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

8.40e-0519410253337042eef91a49f621058785723228cf4dfdad4
ToppCell10x5'-Lung-Lymphocytic_NK|Lung / Manually curated celltypes from each tissue

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

8.61e-051951025a5a10ef9254c266316e5591bec19e159cc3caead
ToppCelllymphoid-T_cell-Regulatory_T_cell|World / Lineage, cell class and subclass

ZBTB16 NPDC1 SAMHD1 ZNF462 ZBTB32

8.82e-05196102542a4d706382be33d552ece1d0598d073857a8d4e
ToppCellHealthy/Control-gd_T|Healthy/Control / Disease group and Cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

8.82e-051961025a6f9e55cd1cd7facadb3f508bded68023c997f3f
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZBTB16 TRPC4 SAMHD1 PDE7B TBX2

8.82e-0519610252ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCellControl-Lymphocyte-T_NK-NK|Control / Disease, Lineage and Cell Type

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

8.82e-05196102565838fddc920cdcecefe823f3ce1c95a7e50e82b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBTB16 SYNE1 CASZ1 PRF1 MYOM2

8.82e-05196102508714b70ddaee7d11397c1dd4a287d412edd90f7
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBTB16 SYNE1 CASZ1 PRF1 MYOM2

8.82e-0519610255bcc959db7deb34d5a32d3464367d47d4945cdaf
ToppCelllymphoid-T_cell-Regulatory_T_cell|lymphoid / Lineage, cell class and subclass

ZBTB16 NPDC1 SAMHD1 ZNF462 ZBTB32

9.03e-05197102573d5dcf076caae60ea32258b4e9dcac8979a661e
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZBTB16 SYNE1 DDX6 PRF1 MYOM2

9.25e-051981025a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCellCOVID-19_Moderate-CD8+_Tem|World / disease group, cell group and cell class

SYNE1 PITPNC1 DDX6 PRF1 MYOM2

9.25e-0519810251d12be256af028c88e31fb535068bae16b7bd48e
ToppCellsevere_COVID-19-CD8+_Tem|severe_COVID-19 / disease group, cell group and cell class (v2)

SYNE1 NPDC1 PITPNC1 DDX6 PRF1

9.25e-05198102569d49f37cf5095e65c71cddc6d43748322ff19a3
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZBTB16 SYNE1 DDX6 PRF1 MYOM2

9.25e-05198102576aff381403bc5a8a9cc73eb1e5dbdc0bac7de6c
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 NPDC1 GDF10 CNTNAP5 TBX2

9.25e-051981025dac7b68bb8f1c4d8aa7fdfada61f79956866e874
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZBTB16 SYNE1 DDX6 PRF1 MYOM2

9.25e-051981025a781fd35a7cda8b7760c2e3ddccaac7aac26c979
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 SYNE1 MYOM2 HS6ST3 TBX2

9.25e-051981025c12e7511628db819a52959bb68580e27c00c2e41
ToppCelllymphoid-T_cell-Regulatory_T_cell|T_cell / Lineage, cell class and subclass

ZBTB16 NPDC1 SAMHD1 ZNF462 ZBTB32

9.25e-0519810256773c6043ef4a3d9e9700330b6386431ee66abdc
ToppCellHealthy_donor-gd_T|World / disease group, cell group and cell class (v2)

SYNE1 PITPNC1 DDX6 PRF1 MYOM2

9.25e-0519810250c3475936f148f2c026501c61b43bcb94d320c48
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

ZNF462 HS3ST1 HS6ST3 RSBN1L PDZRN4

9.25e-051981025de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZBTB16 SYNE1 DDX6 PRF1 MYOM2

9.25e-051981025df399674345c45738d765a8354ea8d1484572c34
ToppCellsevere-NK|severe / disease stage, cell group and cell class

SYNE1 ZNF699 DDX6 PRF1 MYOM2

9.25e-051981025cb505077dc5bdf3fdd513bb9032e32bb9644c004
ToppCellCOVID-19_Moderate-NK|World / disease group, cell group and cell class

ZBTB16 SYNE1 PITPNC1 PRF1 MYOM2

9.47e-051991025c41b67b760831c7d5e19fabcc932a056dc560f93
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 GDF10 ZNF462 CNTNAP5 PDE7B

9.47e-05199102519a97e27a4758e794ce7246d295e112b47931a48
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 TRPC4 TBX2 PDZRN4 DNTT

9.47e-051991025b1753474152b82a0b811b9878c890a359e14919a
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-gd_T|COVID-19_Mild / Disease, condition lineage and cell class

ZBTB16 SYNE1 DDX6 PRF1 MYOM2

9.69e-0520010256560753d3df2f87860b52052d4881aa45410f666
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPC4 GRIN2D PITPNC1 IL1RAPL1 ASPM

9.69e-0520010251276bfa911fddada4235e12e3081baa53164574b
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-NK|Influenza_Severe / Disease, condition lineage and cell class

SYNE1 PITPNC1 DDX6 PRF1 MYOM2

9.69e-05200102504ac14414d550b14dc46d682e7af9dd43982211a
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NAALAD2 SYNE1 SAMHD1 GDF10 TBX2

9.69e-0520010253dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZBTB16 SYNE1 SAMHD1 TBX2 PDZRN4

9.69e-052001025c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellsevere-NK|World / disease stage, cell group and cell class

ZBTB16 ZNF699 DDX6 PRF1 MYOM2

9.69e-052001025320cb0d79adaa1b43d90d027a876cd74f8b55ec3
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK|Influenza_Severe / Disease, condition lineage and cell class

SYNE1 PITPNC1 DDX6 PRF1 MYOM2

9.69e-052001025b3df52881c3ce8ef193f644a26fc5daacfd59d23
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPH1 VN1R1 ZNF684 PDZRN4

2.62e-0413510245113bb1713f99d01103b9a99de5d80393081cf87
ToppCellLPS-IL1RA-Endothelial-Epi-like-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF12 MYOM2 HS6ST3 TMEM181

2.85e-0413810245f8ac8f67e34a7cf560099208e6884102532391e
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRRC39 CEP152 NCK2 RAB33B

3.18e-041421024b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CASZ1 CNTNAP5 HS6ST3 TBX2

3.44e-0414510249964d6d3769be2f35d86268fe044cecd1d5a1616
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNTNAP5 NBEAL2 ASPM HS6ST3

4.01e-041511024c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPH1 USP13 DNAH5 PDZRN4

4.11e-041521024d5ba87b5d34e52cef8475befafea962d70fa8a1d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPH1 USP13 DNAH5 PDZRN4

4.11e-041521024d88d68a788a3256671ebbc06e104833f1f58f07d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 NAALAD2 PPFIA4 TBX2

4.11e-0415210240cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellDividing_Macrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

TRIM45 ZNF684 ASPM POLQ

4.11e-041521024e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 NAALAD2 PPFIA4 TBX2

4.11e-041521024ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZBTB16 IL1RAPL1 MYOM2 TBX2

4.22e-0415310241524557514668f515ac1bbe847611f564b265b42
DiseaseIntellectual Disability

AKAP6 SYNE1 GRIN2D GTF3C3 DDX6 ZNF462 ZNF526 ZBTB11 HTT

2.01e-05447999C3714756
Diseasecentral nervous system cancer, glioma

AKAP6 ZBTB16 RTEL1

1.26e-0429993EFO_0000326, EFO_0005543
Diseasebody surface area

SLC38A9 MAX SAMHD1 DDX6 ZNF462 GLIS2 ZNF844 HS6ST3 RSBN1L

3.18e-04643999EFO_0022196
DiseaseAutosomal recessive primary microcephaly

ASPM CEP152

1.14e-0315992cv:C3711387
Diseasecortical thickness

AKAP6 ZBTB16 LHFPL4 PRDM5 GDF10 ZNF462 ZBTB32 UMODL1 GLIS2 USP15 PDZRN4

1.27e-0311139911EFO_0004840
DiseaseParoxysmal atrial fibrillation

AKAP6 PPFIA4 CASZ1 ZNF462

1.92e-03156994C0235480
Diseasefamilial atrial fibrillation

AKAP6 PPFIA4 CASZ1 ZNF462

1.92e-03156994C3468561
DiseasePersistent atrial fibrillation

AKAP6 PPFIA4 CASZ1 ZNF462

1.92e-03156994C2585653
DiseaseAtrial Fibrillation

AKAP6 PPFIA4 CASZ1 ZNF462

2.10e-03160994C0004238
DiseasePrimary microcephaly

ASPM CEP152

2.46e-0322992C0431350
Diseaseblood pressure

SYNE1 CNTNAP5

2.46e-0322992EFO_0004325
DiseaseAutosomal Recessive Primary Microcephaly

ASPM CEP152

2.46e-0322992C3711387
DiseaseCOVID-19, mortality

GRIN2D LRRC74A ZNF12 CNTNAP5

2.62e-03170994EFO_0004352, MONDO_0100096
DiseaseHuntington's disease (is_implicated_in)

NPY2R HTT

2.69e-0323992DOID:12858 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
STQNHTFHVRVYRGM

UMODL1

336

Q5DID0
YLQHHAFLNARRKEM

FAM228B

61

P0C875
AKMRQEHRNRVFHDF

DDX6

366

P26196
EHMHNRFVVYRDLKP

GRK3

306

P35626
RTYQQHHEAMKTQIR

CEP152

676

O94986
RFTSKQDVIRHYNMH

CASZ1

501

Q86V15
DSLQHRYTSRKMHDF

FAM47DP

216

A6NHR8
HRIRHFYMRKVKFTQ

GTPBP4

41

Q9BZE4
RFTQNHMLIYHKRCH

GZF1

471

Q9H116
VEENRQYRMHSLQHK

CAPN5

431

O15484
KVLSREHYDHQRMQA

DPH1

261

Q9BZG8
IQSTFRMHRLHMRYQ

ASPM

2341

Q8IZT6
EHMHNRFVVYRDLKP

GRK2

306

P25098
VRTLTYRNSMFHNRH

PRMT1

71

Q99873
RKSMVQHYYRNVHAV

RAB33B

96

Q9H082
RYQEKFTQYMAHVRN

PDZRN4

191

Q6ZMN7
MKETVRDYEHQFHLR

RABEP1

121

Q15276
HFSQRQEAMHTFKQV

ITPR3

1081

Q14573
NDHYHQRRQKTTKML

NPY2R

256

P49146
FTRNDYLKVHMDNIH

PRDM5

611

Q9NQX1
YARVNHNKYMVTERA

PLD3

411

Q8IV08
IQYMRRKNHTHQQDI

MAX

71

P61244
QRRFHTMDELVEHYK

NCK2

346

O43639
HIHTNFRDMYQHLRS

MBTPS1

656

Q14703
DFQHRERVAMHYQMS

JAGN1

16

Q8N5M9
HLKMVDSFHRTSLQY

PPFIA4

986

O75335
HTQMLRVKEFIRFHQ

KCNH6

526

Q9H252
MHTYIQESRRRADHQ

LRRC39

306

Q96DD0
HFHMKLFRAQRNLYI

BCAP31

91

P51572
AVHMHRLYEKYSRQG

GDF10

76

P55107
DLRSTFHNTYHSQMR

IL1RAPL1

606

Q9NZN1
HKMTASFHQTYRERH

PRF1

286

P14222
HRFLVMVQEDYHSQN

PDE7B

156

Q9NP56
RQMHHTDYKFRLAKS

GCGR

336

P47871
FIRNMEESYVNLNHH

LRRC74A

101

Q0VAA2
FNARYKMLIHIRTHT

GLIS2

216

Q9BZE0
EASKLYHEHYMRNSR

LHFPL4

6

Q7Z7J7
VRNKAEFHHSIMSQY

DSG1

351

Q02413
NHSHTRNFYYITMLR

HS6ST3

231

Q8IZP7
RLAQSAEMYHYQHQR

NPDC1

241

Q9NQX5
HAIYRHYARTSKQIM

ITCH

796

Q96J02
KNHHMRTVTNYFIVN

HCRTR2

81

O43614
IFYQTCRAVQHMHRQ

GAK

151

O14976
MVSKRENIATHHLYQ

HTT

2561

P42858
TFIRFSHHSYAQMVR

CPZ

181

Q66K79
QRAEHCQKMYEHLRT

CEP290

1071

O15078
FFTINRTYLHHHMTK

FUT10

106

Q6P4F1
RYMHFLENQVRHQLE

DENND11

166

A4D1U4
YVHMYTQRSFQKIVH

FAM111A

511

Q96PZ2
TERQHRQMAIHKRFF

POLQ

706

O75417
RVSDHASAMNKRIHY

SLC38A9

56

Q8NBW4
FLYQHKQSHRTSQMK

CNTNAP5

1261

Q8WYK1
HDYFMSRVRQNLHIV

DNAH5

3071

Q8TE73
VDYKALNRSLYHVHM

HS3ST1

186

O14792
FSMFVRPHHKQRFSQ

RTEL1

1116

Q9NZ71
TMSNFHAQVKRTYSH

RSBN1L

441

Q6PCB5
SRRHQAMAIAYFHPQ

TRMT2A

321

Q8IZ69
AHRRQKKTTYHTMVD

TRIM45

161

Q9H8W5
RMYQSLEHELQKHVS

SYNE1

4026

Q8NF91
DMFHTRNSLHRRAYQ

SAMHD1

361

Q9Y3Z3
RYATHERKMILDNHA

DNTT

461

P04053
AYREQMNEHHKRAYT

SNX25

161

Q9H3E2
NRRFALKATYHAHMV

PRDM15

1026

P57071
HIQYMSSIVREHRQK

NBEAL2

1041

Q6ZNJ1
YSRQHHSIQMKRDKI

WHAMM

506

Q8TF30
QHRIKDYHSYMLQIS

SUPT7L

236

O94864
SYYRHHFMRQDLTQS

SEC23A

601

Q15436
TFIHMASQKYVLRRH

GTF3C3

776

Q9Y5Q9
QHLYKRYSVEMSIRH

AKAP6

996

Q13023
LNSMHRYQPRFHVVF

TBX10

186

O75333
TFNKILTMERIHHYN

ZNF684

106

Q5T5D7
HQYQNRHMKSLVTFT

USPL1

366

Q5W0Q7
KFTQLREYRRHMNNH

ZBTB11

866

O95625
SKMFEILFHRNSQHY

ZBTB16

56

Q05516
SRDYSAMIKHLRTHN

ZBTB16

611

Q05516
IVRHYKRTHQMSSAY

RLF

1566

Q13129
SMHKYQPRFHIVRAN

TBX2

226

Q13207
HKYHVQFASDARQIM

SPIDR

206

Q14159
TMYIHNKVHNRTRTL

TMEM181

246

Q9P2C4
RILKSQHAAMFRHFQ

STX19

131

Q8N4C7
NYTVEDTMHQRKRIH

THAP1

136

Q9NVV9
SMVFFLYRHKQQVQH

VN1R1

241

Q9GZP7
QLYMISKHSHEQSDR

PITPNC1

21

Q9UKF7
YNHRFHRIFAMDENL

USP15

526

Q9Y4E8
LSYLNFQRHMKMHTR

ZNF844

346

Q08AG5
YKENAMRLSRIHHDQ

UGT2A3

436

Q6UWM9
VLKNRHRSHMSEKAY

ZNF16

251

P17020
RSVSTHYQRMHPYIK

ZNF462

856

Q96JM2
FSNMTKFLYHRRTHA

ZNF526

396

Q8TF50
AYDPKHFHNRVSRIM

TPTE2

271

Q6XPS3
RFSLKHQMETHYRVH

ZBTB32

381

Q9Y2Y4
KFFSQMSYLTIHHRI

ZNF12

556

P17014
DYQNKSHERHLRNHM

ZNF699

146

Q32M78
FTMKRYLIAHQRTHS

ZNF614

296

Q8N883
YKENAMRLSRIHHDQ

UGT2A1

436

P0DTE4
YRNHRHQSTEGMSIK

SLC66A2

191

Q8N2U9
HVERHFRKTGQSVYM

USP13

76

Q92995
AADNLRRHHQYQEVM

TRPC4

696

Q9UBN4
DHSHVRQKMLYAATR

TWF1

91

Q12792
HLTRHQRIHTMEKQY

ZNF181

391

Q2M3W8
SDSFRKVRMHVYNIN

NAALAD2

326

Q9Y3Q0
MSLVTVPFYQKRHRH

MYOM2

1

P54296
QNRTHRGESLHRYFM

GRIN2D

351

O15399