Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX1-1 POU3F3 FOXK2 ONECUT3 PBX2 GLIS2 MAFA TLX1 NKX1-2	1.04e-04	1244	32	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	NKX1-1 POU3F3 FOXK2 ONECUT3 PBX2 GLIS2 MAFA TLX1 NKX1-2	1.23e-04	1271	32	9	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXK2 ONECUT3 PBX2 GLIS2 MAFA TLX1	2.31e-04	560	32	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXK2 ONECUT3 PBX2 GLIS2 MAFA TLX1	2.44e-04	566	32	6	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NKX1-1 POU3F3 FOXK2 ONECUT3 PBX2 GLIS2 MAFA TLX1 NKX1-2	2.73e-04	1412	32	9	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NKX1-1 POU3F3 FOXK2 ONECUT3 PBX2 GLIS2 MAFA TLX1 NKX1-2	3.48e-04	1459	32	9	GO:0000977
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	BCL9L POU3F3 ASXL2 FOXK2 ONECUT3 PBX2 GSK3A GLIS2 MAFA TLX1	3.06e-05	1390	32	10	GO:0045944
GeneOntologyCellularComponent	chromatin	NKX1-1 PPP1R10 POU3F3 FOXK2 UPF1 ONECUT3 PBX2 MAFA TLX1 NKX1-2	3.43e-05	1480	31	10	GO:0000785
Domain	Homeobox	NKX1-1 POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	2.50e-06	234	32	6	PF00046
Domain	HOMEOBOX_1	NKX1-1 POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	2.63e-06	236	32	6	PS00027
Domain	HOX	NKX1-1 POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	2.69e-06	237	32	6	SM00389
Domain	Homeobox_dom	NKX1-1 POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	2.83e-06	239	32	6	IPR001356
Domain	HOMEOBOX_2	NKX1-1 POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	2.83e-06	239	32	6	PS50071
Domain	Homeobox_CS	NKX1-1 POU3F3 PBX2 TLX1 NKX1-2	1.50e-05	186	32	5	IPR017970
Domain	Homeodomain-like	NKX1-1 POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	1.85e-05	332	32	6	IPR009057
Domain	-	POU3F3 ONECUT3 PBX2 TLX1 NKX1-2	1.11e-04	283	32	5	1.10.10.60
Domain	Homeobox_metazoa	NKX1-1 TLX1 NKX1-2	4.85e-04	90	32	3	IPR020479
Domain	-	POU3F3 ONECUT3	9.72e-04	27	32	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU3F3 ONECUT3	1.12e-03	29	32	2	IPR010982
Domain	KH_1	SF1 KHSRP	1.92e-03	38	32	2	PF00013
Domain	-	SF1 KHSRP	2.03e-03	39	32	2	3.30.1370.10
Domain	KH	SF1 KHSRP	2.13e-03	40	32	2	SM00322
Domain	KH_dom	SF1 KHSRP	2.13e-03	40	32	2	IPR004087
Domain	KH_TYPE_1	SF1 KHSRP	2.35e-03	42	32	2	PS50084
Domain	KH_dom_type_1	SF1 KHSRP	2.57e-03	44	32	2	IPR004088
Domain	-	YTHDC2 NLGN2	1.76e-02	119	32	2	3.40.50.1820
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	PPP1R10 SRSF11 YTHDC2 EWSR1 UPF1 RPS2 SF1 KHSRP	5.21e-07	807	32	8	22681889
Pubmed	MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.	GSK3A MAFA	8.20e-07	2	32	2	17682063
Pubmed	GSK-3-mediated phosphorylation enhances Maf-transforming activity.	GSK3A MAFA	8.20e-07	2	32	2	18042454
Pubmed	A complex containing PBX2 contributes to activation of the proto-oncogene HOX11.	PBX2 TLX1	8.20e-07	2	32	2	12054735
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	STRN4 SRSF11 EWSR1 FOXK2 SF1 KHSRP	1.55e-06	399	32	6	35987950
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PPP1R10 SRSF11 YTHDC2 EWSR1 RPS2 NEURL4 SF1 KHSRP	3.08e-06	1024	32	8	24711643
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	EWSR1 UPF1 RPS2 SF1 KHSRP	3.69e-06	258	32	5	37794589
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	SRSF11 YTHDC2 EWSR1 UPF1 RPS2 SF1 KHSRP	3.75e-06	731	32	7	29298432
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PPP1R10 SRSF11 EWSR1 UPF1 RPS2 SF1 KHSRP SYNGAP1	4.63e-06	1082	32	8	38697112
Pubmed	The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.	EWSR1 SF1	4.92e-06	4	32	2	9660765
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PPP1R10 YTHDC2 EWSR1 SF1 KHSRP	5.79e-06	283	32	5	30585729
Pubmed	Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.	SRSF11 EWSR1 SF1 KHSRP	1.18e-05	153	32	4	28225217
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	SRSF11 EWSR1 SF1 KHSRP	1.21e-05	154	32	4	16055720
Pubmed	The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.	ASXL2 FOXK2	1.23e-05	6	32	2	24748658
Pubmed	MEIS proteins as partners of the TLX1/HOX11 oncoprotein.	PBX2 TLX1	1.23e-05	6	32	2	19559479
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	STRN4 SRSF11 EWSR1 ASXL2 NEURL4 EML3 GSK3A KHSRP	1.61e-05	1284	32	8	17353931
Pubmed	A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.	PBX2 TLX1	1.72e-05	7	32	2	15944191
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	PPP1R10 YTHDC2 EWSR1 UPF1 RPS2 KHSRP	1.83e-05	615	32	6	31048545
Pubmed	EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.	EWSR1 FOXK2 RPS2 SF1	1.95e-05	174	32	4	35031058
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	BCL9L EWSR1 SF1 KHSRP	2.23e-05	180	32	4	35198878
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	STRN4 EWSR1 NLGN2 UPF1 NEURL4 KHSRP SYNGAP1	2.24e-05	963	32	7	28671696
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	YTHDC2 UPF1 RPS2 SF1 KHSRP	2.52e-05	384	32	5	31059266
Pubmed	The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.	ASXL2 FOXK2	2.94e-05	9	32	2	26416890
Pubmed	MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling.	POU3F3 GSK3A	2.94e-05	9	32	2	25224226
Pubmed	RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.	YTHDC2 UPF1	2.94e-05	9	32	2	36001654
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	SRSF11 YTHDC2 EWSR1 UPF1 RPS2 SF1	3.16e-05	678	32	6	30209976
Pubmed	Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.	POU3F3 ITPR1	3.67e-05	10	32	2	32161359
Pubmed	The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.	ASXL2 FOXK2	3.67e-05	10	32	2	19815555
Pubmed	Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.	ONECUT3 MAFA	3.67e-05	10	32	2	31231191
Pubmed	Hox cofactors in vertebrate development.	PBX2 TLX1	3.67e-05	10	32	2	16515781
Pubmed	ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.	ASXL2 FOXK2	3.67e-05	10	32	2	32669118
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	SRSF11 EWSR1 UBE2Q1 RPS2 SF1 GSK3A	3.90e-05	704	32	6	32994395
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	EWSR1 UPF1 RPS2 SF1 KHSRP	3.90e-05	421	32	5	34650049
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	POU3F3 EWSR1 FOXK2 PBX2 SF1 NKX1-2	4.05e-05	709	32	6	22988430
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	YTHDC2 UPF1 RPS2 KHSRP	5.14e-05	223	32	4	20020773
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	STRN4 UPF1 RPS2 KCNAB3	6.30e-05	235	32	4	30258100
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STRN4 BCL9L RPS2 GSK3A KHSRP ITPR1 SYNGAP1	6.51e-05	1139	32	7	36417873
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	STRN4 IFFO2 PPP1R10 ASXL2 NEURL4 EML3 ITPR1	7.11e-05	1155	32	7	20360068
Pubmed	Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.	EWSR1 UPF1 RPS2 SF1 KHSRP	8.08e-05	491	32	5	22623428
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	STRN4 PPP1R10 EWSR1 RPS2 GSK3A KHSRP	8.41e-05	809	32	6	32129710
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	FZD8 POU3F3	8.55e-05	15	32	2	18255031
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	EWSR1 RPS2 EML3 GSK3A	8.64e-05	255	32	4	15324660
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PPP1R10 FOXK2 RPS2 SF1 KHSRP	9.05e-05	503	32	5	16964243
Pubmed	The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.	ASXL2 FOXK2	9.76e-05	16	32	2	20805357
Pubmed	mTOR regulates brain morphogenesis by mediating GSK3 signaling.	POU3F3 GSK3A	1.11e-04	17	32	2	25273085
Pubmed	Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.	ONECUT3 MAFA	1.24e-04	18	32	2	31969659
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	NLGN2 SYNGAP1	1.24e-04	18	32	2	28864826
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	YTHDC2 EWSR1 UPF1 RPS2 KHSRP	1.39e-04	551	32	5	34728620
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PPP1R10 SRSF11 EWSR1 ASXL2 FOXK2 RPS2 SF1	1.44e-04	1294	32	7	30804502
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	ASXL2 FOXK2	1.54e-04	20	32	2	29785026
Pubmed	A census of human transcription factors: function, expression and evolution.	POU3F3 FOXK2 ONECUT3 PBX2 MAFA TLX1	1.58e-04	908	32	6	19274049
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	UPF1 RPS2 KHSRP	1.59e-04	114	32	3	31553912
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SRSF11 EWSR1 UPF1 RPS2 SF1 GSK3A KHSRP	1.62e-04	1318	32	7	30463901
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	UPF1 KHSRP	1.70e-04	21	32	2	33029523
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PPP1R10 YTHDC2 UPF1 RPS2 SF1 KHSRP	1.84e-04	934	32	6	33916271
Pubmed	Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.	NKX1-1 NKX1-2	1.87e-04	22	32	2	14645517
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	EWSR1 UPF1 KHSRP	1.89e-04	121	32	3	34029587
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PPP1R10 SRSF11 EWSR1 FOXK2 UPF1 SF1 KHSRP	2.06e-04	1371	32	7	36244648
Pubmed	SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.	EWSR1 UPF1 RPS2	2.34e-04	130	32	3	32905556
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	FZD8 YTHDC2	2.43e-04	25	32	2	35874829
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	PPP1R10 SRSF11 EWSR1 RPS2 SF1 KHSRP	2.51e-04	989	32	6	36424410
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PPP1R10 FOXK2 SF1 KHSRP	2.63e-04	341	32	4	32971831
Pubmed	A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.	PBX2 MAFA	2.63e-04	26	32	2	32857951
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	POU3F3 NKX1-2	2.63e-04	26	32	2	22992956
Pubmed	Human transcription factor protein interaction networks.	BCL9L EWSR1 ASXL2 FOXK2 UPF1 PBX2 TLX1	2.66e-04	1429	32	7	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	STRN4 YTHDC2 EWSR1 UPF1 RPS2 KHSRP SYNGAP1	2.68e-04	1431	32	7	37142655
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L ASXL2 FOXK2 PBX2	2.93e-04	351	32	4	38297188
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	YTHDC2 EWSR1 UPF1 RPS2 KHSRP	3.04e-04	653	32	5	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SRSF11 EWSR1 UPF1 RPS2 KHSRP	3.08e-04	655	32	5	35819319
Pubmed	SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses.	FOXK2 RPS2 KHSRP	3.35e-04	147	32	3	33080218
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	STRN4 YTHDC2 UPF1 RPS2 NEURL4 SF1 ITPR1	3.51e-04	1496	32	7	32877691
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	STRN4 PPP1R10 ASXL2 FOXK2 UBE2Q1	3.89e-04	689	32	5	36543142
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	RPS2 SF1 KHSRP	3.99e-04	156	32	3	32850835
Pubmed	c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.	MAFA TLX1	4.00e-04	32	32	2	22514301
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	EWSR1 UPF1	4.00e-04	32	32	2	19542561
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	EWSR1 RPS2 KHSRP	4.22e-04	159	32	3	22751105
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	EWSR1 UPF1 RPS2 SF1 KHSRP	4.37e-04	707	32	5	19738201
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	UPF1 RPS2 KHSRP	4.46e-04	162	32	3	31363146
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EWSR1 ASXL2 FOXK2 UPF1 SF1 KHSRP	4.49e-04	1103	32	6	34189442
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	SRSF11 UPF1 RPS2 SF1 KHSRP	4.57e-04	714	32	5	28302793
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PPP1R10 YTHDC2 UPF1 SF1 KHSRP	4.87e-04	724	32	5	36232890
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	SRSF11 EWSR1 UPF1 RPS2 KHSRP	4.90e-04	725	32	5	27025967
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EWSR1 FOXK2 UPF1 RPS2 SF1 KHSRP	5.57e-04	1149	32	6	35446349
Pubmed	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	PPP1R10 PBX2 SYNGAP1	5.58e-04	175	32	3	19851445
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	EWSR1 FOXK2 RPS2 TLX1	5.62e-04	417	32	4	36537216
Pubmed	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	PPP1R10 KHSRP	5.65e-04	38	32	2	23537643
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	SRSF11 UPF1 KHSRP	5.96e-04	179	32	3	36261009
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	BCL9L SRSF11 EWSR1 UPF1	6.03e-04	425	32	4	24999758
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	SRSF11 UPF1 SF1	6.05e-04	180	32	3	30110629
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	YTHDC2 UPF1 RPS2 ITPR1	6.86e-04	440	32	4	34244565
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	FOXK2 UPF1 RPS2 KHSRP	6.92e-04	441	32	4	31239290
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	SRSF11 FAM117B EML3 ITPR1 SYNGAP1 NKX1-2	7.46e-04	1215	32	6	15146197
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SRSF11 EWSR1 UPF1 RPS2 SF1 GSK3A	8.54e-04	1247	32	6	27684187
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	STRN4 EWSR1 RPS2	8.82e-04	205	32	3	27976729
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PPP1R10 YTHDC2 EWSR1 UPF1 RPS2 SF1	8.91e-04	1257	32	6	36526897
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	YTHDC2 UPF1 KHSRP ITPR1	9.12e-04	475	32	4	31040226
Interaction	PUF60 interactions	SRSF11 EWSR1 FOXK2 UPF1 SF1 GSK3A KHSRP	1.48e-06	369	32	7	int:PUF60
Interaction	CAPN13 interactions	PPP1R10 EWSR1 SF1	3.46e-06	19	32	3	int:CAPN13
Interaction	TNIK interactions	STRN4 EWSR1 NLGN2 NEURL4 GSK3A SYNGAP1	2.62e-05	381	32	6	int:TNIK
Interaction	SSBP3 interactions	BCL9L EWSR1 MAFA TLX1	3.66e-05	119	32	4	int:SSBP3
Interaction	HNRNPK interactions	PPP1R10 SRSF11 EWSR1 ASXL2 UPF1 SF1 GSK3A KHSRP	4.24e-05	853	32	8	int:HNRNPK
Interaction	CRX interactions	BCL9L ASXL2 FOXK2 PBX2 GLIS2	4.66e-05	254	32	5	int:CRX
Interaction	DYNLL2 interactions	STRN4 IFFO2 EWSR1 FAM117B EML3	5.50e-05	263	32	5	int:DYNLL2
Interaction	CAND1 interactions	SRSF11 YTHDC2 EWSR1 ASXL2 UPF1 RPS2 KHSRP SYNGAP1	5.91e-05	894	32	8	int:CAND1
Interaction	U2AF2 interactions	SRSF11 EWSR1 UPF1 SF1 GSK3A GLIS2 KHSRP	5.91e-05	651	32	7	int:U2AF2
Interaction	EEF1B2 interactions	STRN4 EWSR1 ASXL2 RPS2 SYNGAP1	6.01e-05	268	32	5	int:EEF1B2
Interaction	PRPF40A interactions	PPP1R10 SRSF11 EWSR1 ASXL2 SF1 GSK3A	6.32e-05	446	32	6	int:PRPF40A
Interaction	RC3H2 interactions	SRSF11 YTHDC2 EWSR1 UPF1 RPS2 SF1 GSK3A	6.89e-05	667	32	7	int:RC3H2
Interaction	CELF1 interactions	SRSF11 EWSR1 UPF1 SF1 KHSRP	8.45e-05	288	32	5	int:CELF1
Interaction	KDM6A interactions	ASXL2 FOXK2 MAFA TLX1	1.21e-04	162	32	4	int:KDM6A
Interaction	SPDL1 interactions	STRN4 EWSR1 UPF1 RPS2 KCNAB3	1.29e-04	315	32	5	int:SPDL1
Interaction	SHOX interactions	PBX2 GLIS2	1.33e-04	11	32	2	int:SHOX
Interaction	CTNNB1 interactions	BCL9L EWSR1 FAM117B ASXL2 RPS2 GSK3A GLIS2 SYNGAP1	1.38e-04	1009	32	8	int:CTNNB1
Interaction	IL2 interactions	FOXK2 KHSRP	2.20e-04	14	32	2	int:IL2
Interaction	MSC interactions	EWSR1 PBX2	2.53e-04	15	32	2	int:MSC
Interaction	WWP2 interactions	PPP1R10 YTHDC2 EWSR1 UPF1 RPS2 SF1 KHSRP	2.88e-04	840	32	7	int:WWP2
Interaction	MAGEA9 interactions	IFFO2 UBE2Q1 NEURL4 ITPR1	3.16e-04	208	32	4	int:MAGEA9
Interaction	HDLBP interactions	PPP1R10 SRSF11 EWSR1 FOXK2 UPF1 SF1 KHSRP	3.20e-04	855	32	7	int:HDLBP
Interaction	BCL9 interactions	BCL9L EWSR1 TLX1	3.40e-04	86	32	3	int:BCL9
Interaction	CFAP58 interactions	FBXL17 YTHDC2	3.68e-04	18	32	2	int:CFAP58
Interaction	ZC3H18 interactions	SRSF11 YTHDC2 EWSR1 UPF1 RPS2 SF1 KHSRP	3.74e-04	877	32	7	int:ZC3H18
Interaction	MBD6 interactions	ASXL2 FOXK2 KHSRP	4.02e-04	91	32	3	int:MBD6
Interaction	OASL interactions	SRSF11 YTHDC2 UPF1 RPS2	4.11e-04	223	32	4	int:OASL
Interaction	CTBP1 interactions	EWSR1 FOXK2 SF1 GLIS2 KHSRP	4.16e-04	406	32	5	int:CTBP1
Interaction	HOXA5 interactions	PPP1R10 UPF1 PBX2	4.42e-04	94	32	3	int:HOXA5
Interaction	RPS19 interactions	PPP1R10 YTHDC2 EWSR1 ASXL2 RPS2 GSK3A	4.45e-04	639	32	6	int:RPS19
Interaction	FOXC1 interactions	EWSR1 PBX2 KHSRP TLX1	4.47e-04	228	32	4	int:FOXC1
Interaction	EWSR1 interactions	BCL9L POU3F3 SRSF11 EWSR1 UPF1 SF1 GSK3A	4.55e-04	906	32	7	int:EWSR1
Interaction	SUZ12 interactions	BCL9L EWSR1 ASXL2 UPF1 SF1 KHSRP	4.64e-04	644	32	6	int:SUZ12
Interaction	TRMT112 interactions	SRSF11 ASXL2 UPF1	4.70e-04	96	32	3	int:TRMT112
Interaction	HEXIM1 interactions	PPP1R10 SRSF11 YTHDC2 EWSR1 RPS2 SF1 KHSRP	4.76e-04	913	32	7	int:HEXIM1
Interaction	CCDC8 interactions	YTHDC2 EWSR1 RPS2 NEURL4 SF1 KHSRP	5.11e-04	656	32	6	int:CCDC8
Interaction	STAU2 interactions	UPF1 RPS2 GSK3A SYNGAP1	5.18e-04	237	32	4	int:STAU2
Interaction	XRCC6 interactions	PPP1R10 YTHDC2 EWSR1 ASXL2 SF1 KHSRP TLX1	5.25e-04	928	32	7	int:XRCC6
Interaction	PRMT1 interactions	FBXL17 YTHDC2 EWSR1 ASXL2 UPF1 RPS2 KHSRP	5.29e-04	929	32	7	int:PRMT1
Interaction	PER1 interactions	EWSR1 FOXK2 UPF1	5.30e-04	100	32	3	int:PER1
Interaction	MAP7 interactions	YTHDC2 UPF1 NEURL4 GSK3A	5.34e-04	239	32	4	int:MAP7
Interaction	FXR2 interactions	STRN4 EWSR1 UPF1 RPS2 GSK3A	5.41e-04	430	32	5	int:FXR2
Interaction	HMBS interactions	EWSR1 GSK3A	5.53e-04	22	32	2	int:HMBS
Interaction	POU3F3 interactions	POU3F3 EWSR1	5.53e-04	22	32	2	int:POU3F3
Interaction	CIC interactions	YTHDC2 EWSR1 FOXK2 PBX2 RPS2 TLX1	5.85e-04	673	32	6	int:CIC
Interaction	RHOXF2 interactions	EWSR1 UPF1 NKX1-2	5.94e-04	104	32	3	int:RHOXF2
Interaction	DACH1 interactions	SRSF11 EWSR1 TLX1	5.94e-04	104	32	3	int:DACH1
Interaction	OGT interactions	SRSF11 EWSR1 ASXL2 UBE2Q1 RPS2 SF1 GSK3A	6.04e-04	950	32	7	int:OGT
Interaction	SSBP2 interactions	BCL9L EWSR1 TLX1	6.11e-04	105	32	3	int:SSBP2
Interaction	THRAP3 interactions	SRSF11 EWSR1 FOXK2 UPF1 GSK3A	6.19e-04	443	32	5	int:THRAP3
Interaction	GADD45A interactions	UPF1 RPS2 KHSRP	6.63e-04	108	32	3	int:GADD45A
Interaction	TRIM31 interactions	EWSR1 UPF1 RPS2 SF1 KHSRP	6.92e-04	454	32	5	int:TRIM31
Interaction	GLUD1 interactions	PPP1R10 EWSR1 GSK3A SYNGAP1	7.12e-04	258	32	4	int:GLUD1
Interaction	MECP2 interactions	PPP1R10 SRSF11 EWSR1 UPF1 RPS2 SF1 KHSRP SYNGAP1	7.16e-04	1287	32	8	int:MECP2
Cytoband	6p21.3	PPP1R10 PBX2 SYNGAP1	7.04e-04	250	32	3	6p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	NLGN2 NEURL4 KCNAB3	1.79e-03	346	32	3	chr17p13
Cytoband	17p13.1	NLGN2 KCNAB3	3.09e-03	118	32	2	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	PPP1R10 PBX2 SYNGAP1	5.12e-03	503	32	3	chr6p21
Cytoband	19q13.2	STRN4 GSK3A	5.86e-03	164	32	2	19q13.2
Cytoband	19p13.3	ONECUT3 KHSRP	1.19e-02	237	32	2	19p13.3
Cytoband	16p13.3	RPS2 GLIS2	1.26e-02	244	32	2	16p13.3
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX1-1 TLX1 NKX1-2	9.31e-05	67	24	3	519
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R10 ITPR1	2.38e-02	181	24	2	694
GeneFamily	RNA binding motif containing	SRSF11 EWSR1	3.22e-02	213	24	2	725
Disease	schizophrenia (implicated_via_orthology)	NLGN2 SYNGAP1	2.48e-03	68	32	2	DOID:5419 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	ITPR1 SYNGAP1	4.58e-03	93	32	2	C1535926
Disease	C-reactive protein measurement	FBXL17 YTHDC2 UBE2Q1 EML3 ITPR1	9.09e-03	1206	32	5	EFO_0004458
Disease	FEV/FEC ratio	FBXL17 PBX2 UBE2Q1 GLIS2 ITPR1	9.78e-03	1228	32	5	EFO_0004713

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGGPGGPGGPGGPMG	EWSR1	471	Q01844
PGPGPGGGQGPGEGG	ASXL2	691	Q76L83
GGPGEPPGGGDPGGG	PBX2	26	P40425
PSPGTGGGGGAGGGG	MAFA	71	Q8NHW3
GGPGKPGGGGGGSGS	ITPR1	1776	Q14643
GGGGAGGGGSPPGGW	FOXK2	21	Q01167
GSGGGGGMGPGLPGP	GLIS2	391	Q9BZE0
TPPGGPGGPGGGGAG	UPF1	46	Q92900
PGGPGGGGAGGPGGA	UPF1	51	Q92900
GPGGGGGPGGGGGSL	FZD8	651	Q9H461
GGGGGPGGSASGPGG	GSK3A	31	P49840
GGGPGGSGGGGSGGP	GSK3A	66	P49840
GGASGPAGGGGGGGP	FAM117B	71	Q6P1L5
GGGGGGPAGGGASPP	FBXL17	226	Q9UF56
APGGGGGGGGVPGKP	BCL9L	221	Q86UU0
CPPGGGGGGCPGGGG	IFFO2	16	Q5TF58
PGGGGGGGGAGPGPS	IFFO2	26	Q5TF58
PGGGPGGPGGGGQRH	EML3	286	Q32P44
RGGGGPGGGAPGGPG	NLGN2	16	Q8NFZ4
APPGPGGGGGGAGGG	POU3F3	236	P20264
GGSGGSGGGPGPGPG	NEURL4	6	Q96JN8
SGGGPGPGPGGGGGP	NEURL4	11	Q96JN8
GPGPGGGGGPSGSGS	NEURL4	16	Q96JN8
HGPHGGGGGPGGSGG	ONECUT3	296	O60422
GGGGPGGSGGGPSAG	ONECUT3	301	O60422
PGPGGGNGGPAGGGH	KCNAB3	26	O43448
GGGGPGGGGPGGGSA	KHSRP	41	Q92945
GGGGPGPGAGPGTGL	NKX1-1	366	Q15270
AGGGGGGGSGGSPGP	NKX1-2	241	Q9UD57
AGPGPSGGPGGGGGG	SRSF11	11	Q05519
ADGPGPPGGHGGGGG	SYNGAP1	936	Q96PV0
PSGPGGGSGGGSGGG	SYNGAP1	1046	Q96PV0
TGGPGGPGGPAGGGG	TLX1	76	P31314
GGGGGGPSPCGPGGG	YTHDC2	16	Q9H6S0
PGPAGKGGGGGGSPG	STRN4	41	Q9NRL3
GAAGGPGGPGGPGMG	RPS2	6	P15880
GGGPPNGRGGPGGGM	PPP1R10	731	Q96QC0
GMHGGGPGGPGGGPH	SF1	381	Q15637
GAGGGPGGGPGPGPC	UBE2Q1	26	Q7Z7E8