Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CG-1	CAMTA2 CAMTA1	9.15e-06	2	57	2	PF03859
Domain	CG-1	CAMTA2 CAMTA1	9.15e-06	2	57	2	SM01076
Domain	CG-1_dom	CAMTA2 CAMTA1	9.15e-06	2	57	2	IPR005559
Domain	CG_1	CAMTA2 CAMTA1	9.15e-06	2	57	2	PS51437
Domain	Adaptor_Cbl_EF_hand-like	CBL CBLB	2.74e-05	3	57	2	IPR014741
Domain	Adaptor_Cbl_SH2-like	CBL CBLB	2.74e-05	3	57	2	IPR014742
Domain	Cbl_N2	CBL CBLB	2.74e-05	3	57	2	PF02761
Domain	Cbl_N3	CBL CBLB	2.74e-05	3	57	2	PF02762
Domain	Cbl_N	CBL CBLB	2.74e-05	3	57	2	PF02262
Domain	Adaptor_Cbl_N_hlx	CBL CBLB	2.74e-05	3	57	2	IPR003153
Domain	CBL_PTB	CBL CBLB	2.74e-05	3	57	2	PS51506
Domain	Adaptor_Cbl	CBL CBLB	2.74e-05	3	57	2	IPR024162
Domain	Cbl_PTB	CBL CBLB	2.74e-05	3	57	2	IPR024159
Domain	-	CBL CBLB	2.74e-05	3	57	2	1.20.930.20
Domain	NACHT	NLRP14 NLRC5 NLRP13	4.57e-05	23	57	3	PS50837
Domain	NACHT_NTPase	NLRP14 NLRC5 NLRP13	4.57e-05	23	57	3	IPR007111
Domain	Claudin	CACNG3 CACNG2 CLDN2	8.36e-05	28	57	3	IPR006187
Domain	IQ	OBSCN CAMTA2 CAMTA1 MYO16	1.09e-04	81	57	4	SM00015
Domain	IQ_motif_EF-hand-BS	OBSCN CAMTA2 CAMTA1 MYO16	1.64e-04	90	57	4	IPR000048
Domain	IQ	OBSCN CAMTA2 CAMTA1 MYO16	1.86e-04	93	57	4	PS50096
Domain	PMP22_Claudin	CACNG3 CACNG2 CLDN2	2.46e-04	40	57	3	PF00822
Domain	VDCC_gsu	CACNG3 CACNG2	2.53e-04	8	57	2	IPR008368
Domain	PMP22/EMP/MP20/Claudin	CACNG3 CACNG2 CLDN2	3.49e-04	45	57	3	IPR004031
Domain	-	RAG1 TRIM61 ASH1L ZFYVE26 CBL CBLB PHF13	4.15e-04	449	57	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RAG1 TRIM61 ASH1L ZFYVE26 CBL CBLB PHF13	4.73e-04	459	57	7	IPR013083
Domain	LRR_6	NLRP14 NLRC5 NLRP13	6.32e-04	55	57	3	PF13516
Domain	TSP_1	ADAMTS12 ADAMTS20 RSPO1	9.40e-04	63	57	3	PF00090
Domain	TSP1	ADAMTS12 ADAMTS20 RSPO1	1.03e-03	65	57	3	SM00209
Domain	TSP1_rpt	ADAMTS12 ADAMTS20 RSPO1	1.03e-03	65	57	3	IPR000884
Domain	TSP1	ADAMTS12 ADAMTS20 RSPO1	1.03e-03	65	57	3	PS50092
Domain	IQ	OBSCN CAMTA2 CAMTA1	1.33e-03	71	57	3	PF00612
Domain	Znf_RING_CS	RAG1 TRIM61 CBL CBLB	1.54e-03	163	57	4	IPR017907
Domain	Znf_C3HC4_RING-type	RAG1 TRIM61 CBL CBLB	1.88e-03	172	57	4	IPR018957
Domain	DAPIN	NLRP14 NLRP13	2.03e-03	22	57	2	PS50824
Domain	PYRIN	NLRP14 NLRP13	2.03e-03	22	57	2	PF02758
Domain	DAPIN	NLRP14 NLRP13	2.03e-03	22	57	2	IPR004020
Domain	PYRIN	NLRP14 NLRP13	2.03e-03	22	57	2	SM01289
Domain	ADAM_spacer1	ADAMTS12 ADAMTS20	2.22e-03	23	57	2	IPR010294
Domain	ADAM_spacer1	ADAMTS12 ADAMTS20	2.22e-03	23	57	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTS20	2.42e-03	24	57	2	IPR013273
Domain	ArfGap	AGAP11 ARAP2	3.52e-03	29	57	2	SM00105
Domain	ArfGap	AGAP11 ARAP2	3.52e-03	29	57	2	PF01412
Domain	ARFGAP	AGAP11 ARAP2	3.52e-03	29	57	2	PS50115
Domain	ArfGAP	AGAP11 ARAP2	3.52e-03	29	57	2	IPR001164
Domain	UBA	CBL CBLB	3.77e-03	30	57	2	SM00165
Domain	TIG	CAMTA2 CAMTA1	4.02e-03	31	57	2	PF01833
Domain	IPT	CAMTA2 CAMTA1	4.28e-03	32	57	2	IPR002909
Domain	zf-C3HC4	RAG1 TRIM61 CBL CBLB	4.77e-03	223	57	4	PF00097
Domain	Ank	CAMTA2 AGAP11 CAMTA1 MYO16	5.15e-03	228	57	4	PF00023
Domain	PH	PLEKHG1 OBSCN AGAP11 ARAP2	5.23e-03	229	57	4	PF00169
Domain	UBA	CBL CBLB	5.39e-03	36	57	2	PF00627
Domain	GDS_CDC24_CS	PLEKHG1 OBSCN	6.31e-03	39	57	2	IPR001331
Domain	Peptidase_M12B_N	ADAMTS12 ADAMTS20	6.31e-03	39	57	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS12 ADAMTS20	6.31e-03	39	57	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS12 ADAMTS20	6.63e-03	40	57	2	PS00427
Domain	Reprolysin	ADAMTS12 ADAMTS20	6.63e-03	40	57	2	PF01421
Domain	ADAM_MEPRO	ADAMTS12 ADAMTS20	6.63e-03	40	57	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAMTS20	6.63e-03	40	57	2	PS50214
Domain	Peptidase_M12B	ADAMTS12 ADAMTS20	6.63e-03	40	57	2	IPR001590
Domain	-	CAMTA2 AGAP11 CAMTA1 MYO16	6.91e-03	248	57	4	1.25.40.20
Domain	Disintegrin_dom	ADAMTS12 ADAMTS20	6.95e-03	41	57	2	IPR001762
Domain	ANK_REPEAT	CAMTA2 AGAP11 CAMTA1 MYO16	7.41e-03	253	57	4	PS50088
Domain	BTB	BACH1 KBTBD8 KBTBD7	7.49e-03	131	57	3	PF00651
Pubmed	Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.	RAG1 CBL CBLB	4.88e-09	3	60	3	34630435
Pubmed	Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.	RAG1 CBL CBLB	7.97e-07	11	60	3	29562201
Pubmed	Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.	CBL CBLB	2.93e-06	2	60	2	25871390
Pubmed	TARP redundancy is critical for maintaining AMPA receptor function.	CACNG3 CACNG2	2.93e-06	2	60	2	18753375
Pubmed	Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.	TGFBR2 RAG1	2.93e-06	2	60	2	22972928
Pubmed	Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.	CBL CBLB	2.93e-06	2	60	2	17056522
Pubmed	TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.	TGFBR2 RAG1	2.93e-06	2	60	2	22634866
Pubmed	Association of a new c-Cbl related protein with the very first stages of apoptosis induction.	CBL CBLB	2.93e-06	2	60	2	12102152
Pubmed	Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications.	CACNG3 CACNG2	2.93e-06	2	60	2	10221464
Pubmed	Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.	CBL CBLB	2.93e-06	2	60	2	32584413
Pubmed	A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.	CBL CBLB	2.93e-06	2	60	2	27276677
Pubmed	Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor.	CAMTA2 CAMTA1	2.93e-06	2	60	2	25049392
Pubmed	Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.	CBL CBLB	2.93e-06	2	60	2	17475912
Pubmed	A novel family of calmodulin-binding transcription activators in multicellular organisms.	CAMTA2 CAMTA1	2.93e-06	2	60	2	11925432
Pubmed	Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.	CBL CBLB	2.93e-06	2	60	2	26177294
Pubmed	The role of E3 ubiquitin ligase Cbl proteins in β-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells.	CBL CBLB	2.93e-06	2	60	2	23665906
Pubmed	Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.	CBL CBLB	2.93e-06	2	60	2	24994594
Pubmed	The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism.	TGFBR2 CBLB	2.93e-06	2	60	2	19741161
Pubmed	TARPs differentially decorate AMPA receptors to specify neuropharmacology.	CACNG3 CACNG2	2.93e-06	2	60	2	20219255
Pubmed	c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.	CBL CBLB	2.93e-06	2	60	2	12415267
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	PIK3R4 CBL CBLB	4.64e-06	19	60	3	31959764
Pubmed	Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance.	CBL CBLB	8.77e-06	3	60	2	20038312
Pubmed	A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling.	TGFBR2 RAG1	8.77e-06	3	60	2	25577439
Pubmed	Regulation of immune responses by E3 ubiquitin-protein ligases.	CBL CBLB	8.77e-06	3	60	2	11826757
Pubmed	A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice.	CACNG3 CACNG2	8.77e-06	3	60	2	15677329
Pubmed	DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII.	TGFBR2 CBL	8.77e-06	3	60	2	31315051
Pubmed	Cbl-b regulates the CD28 dependence of T-cell activation.	CBL CBLB	8.77e-06	3	60	2	10646609
Pubmed	Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix.	CBL CBLB	8.77e-06	3	60	2	25744063
Pubmed	A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.	CBL CBLB	8.77e-06	3	60	2	10074432
Pubmed	E3 ubiquitin ligases Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer.	CBL CBLB	8.77e-06	3	60	2	29364514
Pubmed	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	CBL CBLB	8.77e-06	3	60	2	12874286
Pubmed	Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.	CBL CBLB	8.77e-06	3	60	2	31282857
Pubmed	Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.	CACNG3 CACNG2	8.77e-06	3	60	2	14505496
Pubmed	Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.	RAG1 CBLB	8.77e-06	3	60	2	19017948
Pubmed	Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights.	CBL CBLB	8.77e-06	3	60	2	18596201
Pubmed	Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.	CBL CBLB	8.77e-06	3	60	2	15265912
Pubmed	[Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].	CBL CBLB	8.77e-06	3	60	2	21645455
Pubmed	T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation.	CBL CBLB	8.77e-06	3	60	2	23684068
Pubmed	Cbl regulates the activity of SIRT2.	CBL CBLB	8.77e-06	3	60	2	25285640
Pubmed	VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.	CBL CBLB	8.77e-06	3	60	2	27449297
Pubmed	Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes.	CBL CBLB	8.77e-06	3	60	2	37903221
Pubmed	Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.	CBL CBLB	8.77e-06	3	60	2	19268472
Pubmed	Cbl negatively regulates JNK activation and cell death.	CBL CBLB	8.77e-06	3	60	2	19546888
Pubmed	The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes.	CBL CBLB	8.77e-06	3	60	2	17330819
Pubmed	A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.	CBL CBLB	8.77e-06	3	60	2	18316398
Pubmed	c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.	CBL CBLB	8.77e-06	3	60	2	21768087
Pubmed	Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).	CBL CBLB	8.77e-06	3	60	2	15315962
Pubmed	The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.	CBL CBLB	8.77e-06	3	60	2	27048651
Pubmed	Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.	CBL CBLB	8.77e-06	3	60	2	15273720
Pubmed	Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.	CBL CBLB	8.77e-06	3	60	2	11087752
Pubmed	The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.	CBL CBLB	8.77e-06	3	60	2	38170572
Pubmed	The NLR gene family: a standard nomenclature.	NLRP14 NLRP13	8.77e-06	3	60	2	18341998
Pubmed	Dimerization quality control ensures neuronal development and survival.	BACH1 KBTBD8 KBTBD7	9.63e-06	24	60	3	30190310
Pubmed	IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.	CBL CBLB	1.75e-05	4	60	2	29237719
Pubmed	Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer.	CACNG2 ADAMTS20	1.75e-05	4	60	2	9065835
Pubmed	SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells.	RAG1 CBL	1.75e-05	4	60	2	38019655
Pubmed	Critical role for TARPs in early development despite broad functional redundancy.	CACNG3 CACNG2	1.75e-05	4	60	2	18634809
Pubmed	Evidence for direct interaction between Sprouty and Cbl.	CBL CBLB	1.75e-05	4	60	2	11053437
Pubmed	Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.	TGFBR2 RAG1	1.75e-05	4	60	2	23686479
Pubmed	Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.	TGFBR2 RAG1	1.75e-05	4	60	2	22966001
Pubmed	CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.	CBL CBLB	1.75e-05	4	60	2	29729186
Pubmed	Hsp70 modulates immune response in pancreatic cancer through dendritic cells.	TGFBR2 RAG1	1.75e-05	4	60	2	34552825
Pubmed	Cbl promotes clustering of endocytic adaptor proteins.	CBL CBLB	1.75e-05	4	60	2	16228008
Pubmed	An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.	CBL CBLB	1.75e-05	4	60	2	28100467
Pubmed	Foxp3-independent mechanism by which TGF-β controls peripheral T cell tolerance.	TGFBR2 RAG1	1.75e-05	4	60	2	28827353
Pubmed	Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.	CBL CBLB	1.75e-05	4	60	2	19815501
Pubmed	Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.	CBL CBLB	1.75e-05	4	60	2	20951942
Pubmed	H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.	CBL CBLB	1.75e-05	4	60	2	26353930
Pubmed	The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.	CBL CBLB	1.75e-05	4	60	2	12935897
Pubmed	High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.	TGFBR2 RAG1	1.75e-05	4	60	2	31451397
Pubmed	Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.	CBL CBLB	1.75e-05	4	60	2	20805496
Pubmed	Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.	CACNG3 CACNG2	1.75e-05	4	60	2	18304745
Pubmed	c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.	TGFBR2 CBL	1.75e-05	4	60	2	23290524
Pubmed	T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.	RAG1 CBLB	2.92e-05	5	60	2	23749633
Pubmed	Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.	CBL CBLB	2.92e-05	5	60	2	17020880
Pubmed	Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.	CBL CBLB	2.92e-05	5	60	2	18239087
Pubmed	Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.	TGFBR2 RAG1	2.92e-05	5	60	2	34335618
Pubmed	Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins.	CBL CBLB	2.92e-05	5	60	2	17045823
Pubmed	c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.	CBL CBLB	2.92e-05	5	60	2	19641021
Pubmed	Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b.	CBL CBLB	2.92e-05	5	60	2	24470255
Pubmed	A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.	CBL CBLB	4.37e-05	6	60	2	11406619
Pubmed	TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.	TGFBR2 RAG1	4.37e-05	6	60	2	24115907
Pubmed	cbl-b inhibits epidermal growth factor receptor signaling.	CBL CBLB	4.37e-05	6	60	2	10086340
Pubmed	SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.	CBL CBLB	4.37e-05	6	60	2	19880507
Pubmed	An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.	CBL CBLB	4.37e-05	6	60	2	30118682
Pubmed	TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.	TGFBR2 RAG1	4.37e-05	6	60	2	23932572
Pubmed	Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.	CBL CBLB	4.37e-05	6	60	2	17493844
Pubmed	p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function.	CBL CBLB	4.37e-05	6	60	2	19190244
Pubmed	Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.	RAG1 CBLB	4.37e-05	6	60	2	26416283
Pubmed	Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.	CBL CBLB	4.37e-05	6	60	2	10635327
Pubmed	Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling.	CBL CBLB	4.37e-05	6	60	2	19915061
Pubmed	Cbl-b restrains priming of pathogenic Th17 cells via the inhibition of IL-6 production by macrophages.	RAG1 CBLB	4.37e-05	6	60	2	36185364
Pubmed	Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.	CACNG2 ADAMTS20	4.37e-05	6	60	2	2289471
Pubmed	TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.	TGFBR2 RAG1	4.37e-05	6	60	2	32451418
Pubmed	CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.	CBL CBLB	4.37e-05	6	60	2	21346257
Pubmed	CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.	CBL CBLB	6.11e-05	7	60	2	17255943
Pubmed	Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.	CBL CBLB	6.11e-05	7	60	2	20037154
Pubmed	Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.	CBL CBLB	6.11e-05	7	60	2	38761804
Pubmed	Synaptic, transcriptional and chromatin genes disrupted in autism.	RALGAPB ASH1L	6.11e-05	7	60	2	25363760
Pubmed	The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.	CBL CBLB	6.11e-05	7	60	2	12842890
GeneFamily	NLR family	NLRP14 NLRC5 NLRP13	2.78e-05	25	43	3	666
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS20	9.21e-04	19	43	2	50
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP14 NLRP13	1.60e-03	25	43	2	994
GeneFamily	Calcium voltage-gated channel subunits	CACNG3 CACNG2	1.73e-03	26	43	2	253
GeneFamily	ArfGAPs	AGAP11 ARAP2	2.78e-03	33	43	2	395
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	BACH1 KBTBD8 KBTBD7	3.96e-03	134	43	3	861
GeneFamily	Ring finger proteins	RAG1 TRIM61 CBL CBLB	4.06e-03	275	43	4	58
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG1 OBSCN	1.08e-02	66	43	2	722
GeneFamily	PHD finger proteins	ASH1L PHF13	1.94e-02	90	43	2	88
GeneFamily	Ankyrin repeat domain containing	AGAP11 MYO16 ARAP2	1.97e-02	242	43	3	403
GeneFamily	WD repeat domain containing	PIK3R4 WDR37 SEC31B	2.42e-02	262	43	3	362
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNG3 XYLT1 MCHR2 ARAP2 ITPR1	5.20e-06	186	60	5	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	SPTSSB TRAPPC10 NBL1 CBLB ARAP2	6.54e-06	195	60	5	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG1 BACH1 ASH1L CAMTA2	4.75e-05	148	60	4	ba277c898678dd36f8dc1d681301c71901b89055
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHG1 BACH1 ASH1L CAMTA2	4.75e-05	148	60	4	b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM201 SFTPB NBL1 PHF13	9.10e-05	175	60	4	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	COPD-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	XYLT1 LINC01619 SPTSSB CBLB	9.10e-05	175	60	4	e773e330de36f8a0aa9398a176ed7edb5599c582
ToppCell	COPD-Lymphoid-ILC_A\|COPD / Disease state, Lineage and Cell class	XYLT1 LINC01619 SPTSSB CBLB	9.30e-05	176	60	4	484452cb38fe4604f0910a068361ed461b5b0c21
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	REC8 CACNG2 WDR37 MYO16	1.06e-04	182	60	4	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ADAMTS20 ROS1 MYO16	1.10e-04	184	60	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ADAMTS20 ROS1 MYO16	1.10e-04	184	60	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ADAMTS20 ROS1 MYO16	1.10e-04	184	60	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Control-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	XYLT1 LINC01619 SPTSSB CBLB	1.15e-04	186	60	4	7bc939bf4e71bb4c6409b862c1f6c547d775e089
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTSSB NBL1 R3HDML RSPO1	1.17e-04	187	60	4	806075c2531a7f5c1da38b85ea494a3b4b5e92ec
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ASH1L CBLB ARAP2 ITPR1	1.20e-04	188	60	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	XYLT1 MCHR2 ARAP2 ITPR1	1.22e-04	189	60	4	a75226616340045b581d08429d2e123e041dee55
ToppCell	COVID-19-T_cells-CD8+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	LINC01619 NLRC5 CBLB ARAP2	1.22e-04	189	60	4	2c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNG3 CACNG2 LRRC3B ITPR1	1.22e-04	189	60	4	3d838da870623a6a278ddc8e6cedca85d9877e50
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRC3B BACH1 OBSCN MYO16	1.25e-04	190	60	4	be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNG2 LRRC3B DISP2 CAMTA1	1.27e-04	191	60	4	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNG2 LRRC3B DISP2 CAMTA1	1.27e-04	191	60	4	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	COVID-19-T_cells-CD4+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	XYLT1 LINC01619 CBLB ARAP2	1.27e-04	191	60	4	0646cca78e24aeb6baa9934d3c439b797c567997
ToppCell	wk_20-22-Epithelial-Distal_epithelial_progenitor\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SFTPB SPTSSB ROS1 CLDN2	1.30e-04	192	60	4	fa2420d6117d4800f60ef6a24bcf8bf54593cd1f
ToppCell	wk_20-22-Epithelial-Distal_epithelial_progenitor-epi-tip_late\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SFTPB SPTSSB ROS1 CLDN2	1.30e-04	192	60	4	87b60014202633a4f6d19b09a5dd9276c2edecfb
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNG2 LRRC3B DISP2 CAMTA1	1.30e-04	192	60	4	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 BACH1 RALGAPB ITPR1	1.33e-04	193	60	4	08696a99309f5b088692ddac8cca35413b5e810d
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRIM61 SFTPB ROS1 TMEM225B	1.35e-04	194	60	4	df835578d86a49ae5af5632152fbab9548c0a448
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRIM61 SFTPB ROS1 TMEM225B	1.35e-04	194	60	4	0715f2d55f4a6d2edda1b3dc52f12d25ce59eb10
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRIM61 SFTPB ROS1 TMEM225B	1.35e-04	194	60	4	a4f7cd507eba40985d82635bbae28c7f5703f883
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SFTPB ROS1 CLDN2 ARAP2	1.38e-04	195	60	4	62d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SFTPB KRTAP29-1 ROS1 CLDN2	1.41e-04	196	60	4	784459f9f3614ead947aeb61a873dfd4cbe50641
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NLRC5 CBLB MYO16 ARAP2	1.44e-04	197	60	4	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPTSSB TRAPPC10 CBLB ARAP2	1.46e-04	198	60	4	58d805e827299292750b09c6283fdbe406b75f79
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ASH1L NLRC5 CBLB ARAP2	1.49e-04	199	60	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	XYLT1 MCHR2 ARAP2 ITPR1	1.52e-04	200	60	4	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RAG1 PLEKHG1 SFTPB NLRC5	1.52e-04	200	60	4	4f7be296be0cd54cfc62cc93263fde26210c61f4
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	MAN2A2 SPTSSB NBL1 PHF13	1.52e-04	200	60	4	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
Disease	clonal hematopoiesis mutation measurement	OR10H4 CBLB ITPR1	1.76e-04	55	58	3	EFO_0020949
Disease	N-acetylmethionine measurement	ALMS1 ITPR1	3.92e-04	15	58	2	EFO_0021427
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	KBTBD8 ITPR1	6.36e-04	19	58	2	EFO_0008582
Disease	kidney disease (biomarker_via_orthology)	XYLT1 TGFBR2	7.78e-04	21	58	2	DOID:557 (biomarker_via_orthology)
Disease	blood pressure	TGFBR2 MYO16	8.55e-04	22	58	2	EFO_0004325
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	SFTPB CBL	1.02e-03	24	58	2	DOID:3827 (biomarker_via_orthology)
Disease	Prostatic Neoplasms	REC8 TGFBR2 RAG1 PCDH11Y ASH1L ITPR1	1.30e-03	616	58	6	C0033578
Disease	Malignant neoplasm of prostate	REC8 TGFBR2 RAG1 PCDH11Y ASH1L ITPR1	1.30e-03	616	58	6	C0376358

Protein segments in the cluster

Peptide	Gene	Start	Entry
FWSDICSTDTPCQMQ	BACH1	401	O14867
INHSCDPNCEMQKWS	ASH1L	2221	Q9NR48
VPWSPLCAAMASCHS	ATP13A5	521	Q4VNC0
VDHFSCTPLMWACAL	CAMTA1	1106	Q9Y6Y1
SHCVDCETQNPKWAS	AGAP11	341	Q8TF27
KTESWHCLPQEMDSS	ALMS1	151	Q8TCU4
EVMTHSGLWRTCCLE	CACNG3	56	O60359
NVDHFSCTPLMWACA	CAMTA2	751	O94983
IEDWNNESSMPCCVL	ADPRM	56	Q3LIE5
HLCCDSSRTQTEWMT	ARAP2	1516	Q8WZ64
CFVETLQRWMESPSC	DISP2	836	A7MBM2
PTSTMSCNEHLCCHW	ADAMTS12	1461	P58397
PHINICMHLWCTSTE	ADAMTS20	501	P59510
TMEWHPHTPSCDICN	RAG1	201	P15918
EQLQTRAHCWECPMV	REC8	321	O95072
EVMTHSGLWRTCCLE	CACNG2	56	Q9Y698
CNWLMPSQKASVESC	ITPR1	1531	Q14643
VVCNNEHCPCSTWMH	HECA	116	Q9UBI9
FWTPMHIACACDNPD	MYO16	126	Q9Y6X6
EPCGHLMCTSCLTAW	CBLB	386	Q13191
TCVQVHRCQTDAPMW	GP2	106	P55259
PWHCDCTLQQVLRSM	LRRC3B	146	Q96PB8
CYDPSHNMWLNCASL	KBTBD7	496	Q8WVZ9
HCDSCMPAQSMWEIV	NBL1	81	P41271
SDTWQSFIHCVCMQL	NLRC5	66	Q86WI3
SRENCWTTVCAMPVA	KBTBD8	416	Q8NFY9
LMSPRDCAHLVACTW	OR10H4	136	Q8NGA5
ECVLSHESASDPAMW	OBSCN	2756	Q5VST9
MNPFHASCWNTSAEL	MCHR2	1	Q969V1
WDSDSSTDIFCHMMP	MAN2A2	336	P49641
WMECATHSTGITQCD	CLDN2	51	P57739
SSCHSRMWQLVTCQE	KRTAP29-1	36	A8MX34
CGHLMCTSCLTSWQE	CBL	396	P22681
MWSAHLLTCADVECH	CRIPAK	81	Q8N1N5
WSKPCHNNATCEDSV	CRB1	306	P82279
CDGPTCSHYTQMVWA	R3HDML	161	Q9H3Y0
HSDACWMPASLDHSS	PCDH11Y	1141	Q9BZA8
EWLPRDSECHLCMSV	SFTPB	291	P07988
QEMVCPCWHLLSTSQ	TMEM225B	171	P0DP42
PCWHLLSTSQSMEED	TMEM225B	176	P0DP42
ECSSPAQCEMSEWSP	RSPO1	141	Q2MKA7
QMVCETLTECWDHDP	TGFBR2	511	P37173
SCCAVLEPWERSMFN	SPTSSB	21	Q8NFR3
VECWAKCHQALSPMA	SEC31B	696	Q9NQW1
HPEWIMSCSELSFCL	AKR1E2	111	Q96JD6
MNVCCSSHPVNEKVW	LINC01619	1	G3V211
CSVPWDACELLATAM	SHANK2-AS3	36	Q9BTD1
ACWDMRFQLPISSHC	PIK3R4	1166	Q99570
CLSCIIMSWKDLHDS	TRIM61	36	Q5EBN2
MIECNECHTWIHLSC	PHF13	246	Q86YI8
ACPVMQTCSQTAWSS	XYLT1	926	Q86Y38
QDCFSISDCPVWMDS	XYLB	126	O75191
AHCTKDASDPLMWTA	TMPRSS12	121	Q86WS5
LACHSEEMWCTESHP	ROS1	1636	P08922
PTHTMVNCWFCNQDT	TMEM201	41	Q5SNT2
AFQCLCVWLTEHPDM	RALGAPB	836	Q86X10
MVCCSAWSEDHPVCN	WDR37	456	Q9Y2I8
LCEDSTSSRPCSWHM	PLEKHG1	576	Q9ULL1
CMVTTDHKVSIDCPW	TRAPPC10	916	P48553
QMCWPSLSEDCVASH	ZFYVE26	1066	Q68DK2
ETLFHSCSAPMVCWT	NLRP13	416	Q86W25
CEDWTQEHPVSFLMS	NLRP14	276	Q86W24