Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein disulfide isomerase activity	P4HB PDIA2 PDILT	6.44e-07	22	16	3	GO:0003756
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing S-S bonds	P4HB PDIA2 PDILT	6.44e-07	22	16	3	GO:0016864
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity	P4HB PDIA2 PDILT	1.20e-05	57	16	3	GO:0016860
GeneOntologyMolecularFunction	protein-disulfide reductase activity	P4HB PDIA2	3.73e-04	36	16	2	GO:0015035
GeneOntologyMolecularFunction	isomerase activity	P4HB PDIA2 PDILT	4.47e-04	192	16	3	GO:0016853
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	P4HB PDIA2	5.33e-04	43	16	2	GO:0015036
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors	P4HB PDIA2	9.36e-04	57	16	2	GO:0016667
GeneOntologyMolecularFunction	integrin binding	P4HB TSPAN8	8.45e-03	175	16	2	GO:0005178
GeneOntologyMolecularFunction	calmodulin binding	PCNT RIT2	1.43e-02	230	16	2	GO:0005516
GeneOntologyBiologicalProcess	protein folding in endoplasmic reticulum	P4HB PDIA2	4.96e-05	13	17	2	GO:0034975
GeneOntologyBiologicalProcess	neuronal stem cell population maintenance	SRRT PCM1	2.05e-04	26	17	2	GO:0097150
GeneOntologyCellularComponent	pericentriolar material	PCM1 PCNT	2.32e-04	28	17	2	GO:0000242
GeneOntologyCellularComponent	endoplasmic reticulum lumen	P4HB PDIA2 COL12A1	2.29e-03	332	17	3	GO:0005788
HumanPheno	Abnormality of the larynx	PON2 P4HB DAO COL12A1 PCNT	3.77e-05	666	5	5	HP:0001600
HumanPheno	Cachexia	PON2 DAO PCNT	7.14e-05	100	5	3	HP:0004326
HumanPheno	Generalized muscle weakness	PON2 DAO COL12A1	1.71e-04	134	5	3	HP:0003324
HumanPheno	Foot dorsiflexor weakness	PON2 DAO COL12A1	2.12e-04	144	5	3	HP:0009027
HumanPheno	Abnormality of the foot musculature	PON2 DAO COL12A1	2.44e-04	151	5	3	HP:0001436
HumanPheno	Proximal muscle weakness in lower limbs	PON2 DAO COL12A1	4.54e-04	186	5	3	HP:0008994
HumanPheno	Abnormality of the upper respiratory tract	PON2 P4HB DAO COL12A1 PCNT	4.90e-04	1111	5	5	HP:0002087
HumanPheno	Progressive distal muscular atrophy	PON2 DAO	5.34e-04	38	5	2	HP:0008955
HumanPheno	Abnormality of the voice	PON2 P4HB DAO PCNT	5.94e-04	545	5	4	HP:0001608
HumanPheno	Jaw hyperreflexia	PON2 DAO	6.23e-04	41	5	2	HP:0033683
HumanPheno	Fatigable weakness of swallowing muscles	PON2 DAO	6.53e-04	42	5	2	HP:0030195
HumanPheno	Laryngospasm	PON2 DAO	6.53e-04	42	5	2	HP:0025425
HumanPheno	Hoffmann sign	PON2 DAO	7.84e-04	46	5	2	HP:0031993
HumanPheno	Abnormally high-pitched voice	P4HB PCNT	8.19e-04	47	5	2	HP:0001620
HumanPheno	Abnormal larynx physiology	PON2 DAO	8.54e-04	48	5	2	HP:0025424
HumanPheno	Amyotrophic lateral sclerosis	PON2 DAO	8.90e-04	49	5	2	HP:0007354
HumanPheno	Frontotemporal dementia	PON2 DAO	1.00e-03	52	5	2	HP:0002145
HumanPheno	Tongue atrophy	PON2 DAO	1.00e-03	52	5	2	HP:0012473
HumanPheno	Lower limb muscle weakness	PON2 DAO COL12A1	1.01e-03	244	5	3	HP:0007340
HumanPheno	Xerostomia	PON2 DAO	1.12e-03	55	5	2	HP:0000217
HumanPheno	Respiratory failure	PON2 DAO COL12A1	1.25e-03	262	5	3	HP:0002878
HumanPheno	Fatigable weakness of respiratory muscles	PON2 DAO	1.25e-03	58	5	2	HP:0030196
HumanPheno	Abnormal pitch	P4HB PCNT	1.33e-03	60	5	2	HP:5200005
HumanPheno	Fatigable weakness of bulbar muscles	PON2 DAO	1.38e-03	61	5	2	HP:0030192
HumanPheno	Motor neuron atrophy	PON2 DAO	1.61e-03	66	5	2	HP:0007373
HumanPheno	Abnormal Intonation	P4HB PCNT	1.76e-03	69	5	2	HP:5200010
HumanPheno	Abnormality of the musculature of the lower limbs	PON2 DAO COL12A1	1.80e-03	297	5	3	HP:0001437
HumanPheno	Tongue fasciculations	PON2 DAO	2.02e-03	74	5	2	HP:0001308
HumanPheno	Bowing of the long bones	P4HB COL12A1 PCNT	2.15e-03	316	5	3	HP:0006487
HumanPheno	Anomaly of the limb diaphyses	P4HB COL12A1 PCNT	2.27e-03	322	5	3	HP:0006504
Domain	THIOREDOXIN_1	P4HB PDIA2 PDILT	1.42e-06	25	17	3	PS00194
Domain	Thioredoxin	P4HB PDIA2 PDILT	2.77e-06	31	17	3	PF00085
Domain	Prot_disulphide_isomerase	P4HB PDIA2	4.67e-06	4	17	2	IPR005792
Domain	Thioredoxin_domain	P4HB PDIA2 PDILT	6.54e-06	41	17	3	IPR013766
Domain	THIOREDOXIN_2	P4HB PDIA2 PDILT	7.56e-06	43	17	3	PS51352
Domain	ER_TARGET	P4HB PDIA2 PDILT	9.91e-06	47	17	3	PS00014
Domain	Disulphide_isomerase	P4HB PDIA2	2.18e-05	8	17	2	IPR005788
Domain	Thioredoxin	P4HB PDIA2	6.05e-05	13	17	2	IPR005746
Domain	Thioredoxin_CS	P4HB PDIA2	1.05e-04	17	17	2	IPR017937
Domain	-	P4HB PDIA2 PDILT	1.73e-04	122	17	3	3.40.30.10
Domain	Thioredoxin-like_fold	P4HB PDIA2 PDILT	2.18e-04	132	17	3	IPR012336
Pubmed	Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum.	P4HB PDIA2	2.25e-07	2	17	2	15225124
Pubmed	Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1.	PCM1 PCNT	2.25e-07	2	17	2	11171385
Pubmed	Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait.	P4HB PDIA2	2.25e-07	2	17	2	14693722
Pubmed	The Involvement of His50 during Protein Disulfide Isomerase Binding Is Essential for Inhibiting α-Syn Fibril Formation.	P4HB PDIA2	6.74e-07	3	17	2	27142583
Pubmed	Protein disulfide isomerase directly interacts with β-actin Cys374 and regulates cytoskeleton reorganization.	P4HB PDIA2	6.74e-07	3	17	2	24415753
Pubmed	Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α).	P4HB PDIA2	6.74e-07	3	17	2	25258311
Pubmed	Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death.	P4HB PDIA2	6.74e-07	3	17	2	12095988
Pubmed	The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha.	P4HB PDIA2	6.74e-07	3	17	2	10970843
Pubmed	Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.	P4HB PDIA2	6.74e-07	3	17	2	24098548
Pubmed	Three binding sites in protein-disulfide isomerase cooperate in collagen prolyl 4-hydroxylase tetramer assembly.	P4HB PDIA2	6.74e-07	3	17	2	15590633
Pubmed	Novel missense MTTP gene mutations causing abetalipoproteinemia.	P4HB PDIA2	1.35e-06	4	17	2	25108285
Pubmed	Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.	P4HB PDIA2	1.35e-06	4	17	2	14500733
Pubmed	Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.	PCM1 PCNT	1.35e-06	4	17	2	20152126
Pubmed	Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.	PCM1 PCNT	1.35e-06	4	17	2	16291865
Pubmed	Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.	P4HB PDIA2	1.35e-06	4	17	2	19942855
Pubmed	Is protein disulfide isomerase a redox-dependent molecular chaperone?	P4HB PDIA2	1.35e-06	4	17	2	12485997
Pubmed	The centriolar satellite protein Cep131 is important for genome stability.	PCM1 PCNT	2.25e-06	5	17	2	22797915
Pubmed	Disulphide production by Ero1α-PDI relay is rapid and effectively regulated.	P4HB PDIA2	3.37e-06	6	17	2	20802462
Pubmed	pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.	P4HB PDIA2	3.37e-06	6	17	2	16677074
Pubmed	Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.	P4HB PDIA2	3.37e-06	6	17	2	14592831
Pubmed	Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.	PCM1 PCNT	3.37e-06	6	17	2	24816561
Pubmed	Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop: differential effects of protein disulfide isomerase on CD4 and coreceptor binding.	P4HB PDIA2	4.72e-06	7	17	2	17301129
Pubmed	Snapshot of the interaction between HIV envelope glycoprotein 120 and protein disulfide isomerase.	P4HB PDIA2	4.72e-06	7	17	2	20458450
Pubmed	Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry.	P4HB PDIA2	4.72e-06	7	17	2	12218051
Pubmed	In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse.	PCM1 PCNT	4.72e-06	7	17	2	16632484
Pubmed	Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection.	P4HB PDIA2	4.72e-06	7	17	2	23206338
Pubmed	Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion.	P4HB PDIA2	6.29e-06	8	17	2	12218052
Pubmed	Proteins of the PDI family: unpredicted non-ER locations and functions.	P4HB PDIA2	6.29e-06	8	17	2	12384992
Pubmed	The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors.	PCM1 PCNT	6.29e-06	8	17	2	22031837
Pubmed	Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing.	P4HB PDIA2	8.08e-06	9	17	2	17055437
Pubmed	SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex.	PCM1 PCNT	1.01e-05	10	17	2	25088364
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	P4HB FRYL PCM1 EPPK1 PCNT	1.18e-05	653	17	5	22586326
Pubmed	A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.	P4HB PDIA2	2.04e-05	14	17	2	12475965
Pubmed	The human protein disulfide isomerase gene family.	PDIA2 PDILT	2.69e-05	16	17	2	23245351
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	PCM1 PCNT	3.83e-05	19	17	2	24421332
Pubmed	SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.	PON2 P4HB COL12A1	7.81e-05	173	17	3	23979707
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SRRT P4HB PCM1 EPPK1 PCNT	1.01e-04	1024	17	5	24711643
Pubmed	A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.	P4HB FRYL EPPK1	1.02e-04	189	17	3	31594818
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	PCM1 EPPK1 PCNT	1.39e-04	210	17	3	16565220
Pubmed	Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.	P4HB PDIA2	1.48e-04	37	17	2	34225486
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	P4HB PCM1 EPPK1	1.93e-04	235	17	3	30258100
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	SRRT AMPH PCM1	2.21e-04	246	17	3	15345747
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PON2 SRRT P4HB FRYL EPPK1	2.90e-04	1284	17	5	17353931
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	PON2 P4HB PCM1 COL12A1 EPPK1	3.04e-04	1297	17	5	33545068
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	P4HB PCM1 PCNT	3.40e-04	285	17	3	32838362
Pubmed	The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.	PCM1 PCNT	3.41e-04	56	17	2	11076968
Pubmed	The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.	PCM1 PCNT	3.53e-04	57	17	2	16462731
Pubmed	Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.	PCM1 PCNT	3.66e-04	58	17	2	12852856
Pubmed	Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.	PCM1 PCNT	4.05e-04	61	17	2	7790358
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	PCM1 PCNT	4.74e-04	66	17	2	12221128
GeneFamily	Protein disulfide isomerases	P4HB PDIA2 PDILT	2.95e-07	21	12	3	692
Drug	Gabazine [105538-73-6]; Up 200; 10.8uM; HL60; HT_HG-U133A	PON2 AIM2 SRRT PCM1	1.12e-05	194	17	4	1316_UP
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	SRRT PDIA2 AMPH EPPK1	1.26e-05	200	17	4	5931_DN
Drug	BPD I	P4HB PDIA2	2.87e-05	11	17	2	CID000032348
Drug	Dithiol	P4HB PDIA2 PDILT	5.35e-05	100	17	3	CID000010334
Drug	Leu-met	PON2 RIT2	6.26e-05	16	17	2	CID000118276
Disease	Bipolar Disorder	SRRT DAO PCNT TSPAN8	1.36e-04	477	17	4	C0005586
Disease	Amyotrophic Lateral Sclerosis	PON2 DAO	5.07e-04	58	17	2	C0002736
Disease	Schizophrenia	DAO PCM1 PCNT TSPAN8	1.39e-03	883	17	4	C0036341
Disease	seasonal gut microbiome measurement	RIT2 TSPAN8	1.87e-03	112	17	2	EFO_0007753
Disease	Major Depressive Disorder	SRRT PCNT	8.47e-03	243	17	2	C1269683
Disease	asthma	AIM2 PCNT TSPAN8	8.56e-03	751	17	3	MONDO_0004979
Disease	Liver Cirrhosis, Experimental	DAO COL12A1 TSPAN8	9.29e-03	774	17	3	C0023893
Disease	Unipolar Depression	SRRT PCNT	9.57e-03	259	17	2	C0041696
Disease	cleft lip	AMPH ZNF283	1.14e-02	284	17	2	EFO_0003959
Disease	apolipoprotein A 1 measurement	PON2 RIT2 TSPAN8	1.19e-02	848	17	3	EFO_0004614

Protein segments in the cluster

Peptide	Gene	Start	Entry
VATEKEFFFVKVFNT	AIM2	181	O14862
EEFQKAQKVFEEFNV	AMPH	171	P49418
GVKFFQRKVESFEEV	DAO	156	P14920
LTQQNDESKEFVKFF	PCM1	1631	Q15154
FAEFAVQAEKKIEVV	FRYL	21	O94915
KNFEQVAFDETKNVF	PDIA2	396	Q13087
NFEDVAFDEKKNVFV	P4HB	376	P07237
FEKEFSFKNEETAQV	PCNT	1291	O95613
FKNTVEIFKFEEAEN	PON2	136	Q15165
DDNFNKVVKFIFNTV	COL12A1	2336	Q99715
NFNVVVFDKEKDVFV	PDILT	396	Q8N807
SFQEAAKFKELIFQV	RIT2	106	Q99578
QVLTAVDKDNKFFFD	EPPK1	1391	P58107
EEVKKEVAFFNNFLT	SRRT	741	Q9BXP5
FEDTFVNFQAAIEKK	PHF11	271	Q9UIL8
KQFQEAIIVFQEEFK	TSPAN8	136	P19075
TKKIFSENDIFEINF	ZNF283	121	Q8N7M2