Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A7 SLC6A8 AQP12A NOX5 SCN5A KCNMB1 PKD1L3 ATP2B4 AQP12B

1.79e-04758549GO:0015318
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A7 SLC6A8 TMEM144 AQP12A NOX5 SCN5A KCNMB1 GRID1 PKD1L3 ATP2B4 AQP12B

2.67e-0411805411GO:0022857
GeneOntologyMolecularFunctioncalmodulin binding

IQCF5 IQCF1 SCN5A ATP2B4 IQCF6

3.88e-04230545GO:0005516
GeneOntologyMolecularFunctionchannel activity

AQP12A NOX5 SCN5A KCNMB1 GRID1 PKD1L3 AQP12B

5.07e-04525547GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

AQP12A NOX5 SCN5A KCNMB1 GRID1 PKD1L3 AQP12B

5.13e-04526547GO:0022803
GeneOntologyMolecularFunctiontransporter activity

SLC6A7 SLC6A8 TMEM144 AQP12A NOX5 SCN5A KCNMB1 GRID1 PKD1L3 ATP2B4 AQP12B

5.67e-0412895411GO:0005215
GeneOntologyMolecularFunctionwater channel activity

AQP12A AQP12B

9.51e-0417542GO:0015250
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A7 SLC6A8 NOX5 SCN5A KCNMB1 GRID1 PKD1L3 ATP2B4

1.23e-03793548GO:0015075
GeneOntologyMolecularFunctionwater transmembrane transporter activity

AQP12A AQP12B

1.32e-0320542GO:0005372
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A7 SLC6A8 NOX5 SCN5A KCNMB1 PKD1L3 ATP2B4

1.43e-03627547GO:0022890
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A7 SLC6A8 SCN5A KCNMB1 PKD1L3 ATP2B4

1.55e-03465546GO:0046873
GeneOntologyMolecularFunctionnitric-oxide synthase binding

SCN5A ATP2B4

1.60e-0322542GO:0050998
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A7 SLC6A8

1.75e-0323542GO:0005283
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A7 SLC6A8 NOX5 SCN5A KCNMB1 PKD1L3 ATP2B4

1.98e-03664547GO:0008324
GeneOntologyMolecularFunctionfibroblast growth factor binding

GPC1 SCN5A

2.41e-0327542GO:0017134
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2T8 FZD7 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 RXFP3

2.44e-03884548GO:0004930
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A7 SLC6A8

2.78e-0329542GO:0005416
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2T8 FZD7 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 GRID1 RXFP3 PKD1L3

3.05e-0313535410GO:0004888
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A7 SLC6A8

4.03e-0335542GO:0005343
DomainAquaporin_12

AQP12A AQP12B

7.60e-062522IPR023265
DomainAquaporin_11/12

AQP12A AQP12B

2.28e-053522IPR016697
DomainIQ_motif_EF-hand-BS

IQCF5 IQCF1 SCN5A IQCF6

1.14e-0490524IPR000048
DomainIQ

IQCF5 IQCF1 SCN5A IQCF6

1.30e-0493524PS50096
DomainMIP

AQP12A AQP12B

6.77e-0414522PS00221
DomainMIP

AQP12A AQP12B

6.77e-0414522PF00230
DomainMIP

AQP12A AQP12B

7.80e-0415522IPR000425
Domain-

AQP12A AQP12B

7.80e-04155221.20.1080.10
DomainAquaporin-like

AQP12A AQP12B

7.80e-0415522IPR023271
DomainIQ

IQCF5 IQCF1 IQCF6

1.02e-0371523PF00612
DomainNA_NEUROTRAN_SYMP_2

SLC6A7 SLC6A8

1.13e-0318522PS00754
DomainSNF

SLC6A7 SLC6A8

1.26e-0319522PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A7 SLC6A8

1.26e-0319522PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A7 SLC6A8

1.26e-0319522PS50267
DomainNa/ntran_symport

SLC6A7 SLC6A8

1.26e-0319522IPR000175
DomainIQ

IQCF5 IQCF1 SCN5A

1.49e-0381523SM00015
DomainGPCR_Rhodpsn_7TM

OR2T8 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 RXFP3

2.44e-03670527IPR017452
Domain7tm_1

OR2T8 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 RXFP3

2.58e-03677527PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2T8 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 RXFP3

2.76e-03685527PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2T8 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 RXFP3

2.89e-03691527PS50262
DomainGPCR_Rhodpsn

OR2T8 OR2A12 HTR5A MRGPRD P2RY6 OR6Q1 RXFP3

2.92e-03692527IPR000276
DomainGDS_CDC24_CS

PLEKHG4 VAV1

5.27e-0339522IPR001331
Pubmed

Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.

AQP12A AQP12B

2.55e-06256219726746
Pubmed

Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.

AQP12A AQP12B

2.55e-06256236167651
Pubmed

Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.

AQP12A AQP12B

2.55e-06256215809071
Pubmed

LIME mediates immunological synapse formation through activation of VAV.

LIME1 VAV1

2.55e-06256222395814
Pubmed

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.

SCN5A ATP2B4

1.52e-05456218591664
Pubmed

eXPRESSION: an in silico tool to predict patterns of gene expression.

SCN5A DGKD SLFNL1

2.49e-053556315939374
Pubmed

Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.

AQP12A AQP12B

2.64e-041556234540996
Pubmed

Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.

AQP12A AQP12B

3.41e-041756226847765
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JAG2 FZD7 SLC6A8 LIME1 SCN5A XXYLT1 GRID1 SFI1

3.72e-04110556835748872
Pubmed

Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.

AQP12A AQP12B

4.28e-041956219367412
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A7 SLC6A8

5.24e-042156216125675
Pubmed

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

HTR5A P2RY6 ZNF213 VAV1 MOS

7.12e-0444056535156780
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

COPA LRRTM2 ABCF2 CTSB

7.91e-0425756430945288
Pubmed

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

SLC6A8 COPA PTDSS1

8.17e-0411356330352685
Pubmed

Large-scale cDNA transfection screening for genes related to cancer development and progression.

LIME1 NRBP2 P2RY6

8.38e-0411456315498874
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

FZD7 SLC6A8 TMEM144 HTR5A PTDSS1 RXFP3

8.79e-0469756628298427
Pubmed

Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

JAG2 PPT1

1.08e-033056219054571
Pubmed

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.

SCN5A ATP2B4

1.08e-033056239366945
Pubmed

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.

NBEA MOS

1.46e-033556215188402
InteractionDLG2 interactions

FZD7 SCN5A OTUD7A GRID1 ATP2B4

1.40e-0683475int:DLG2
Cytoband3p21.2

IQCF5 IQCF1 IQCF6

1.64e-06195633p21.2
CytobandEnsembl 112 genes in cytogenetic band chr2q37

GPC1 AQP12A DGKD AQP12B

1.72e-04226564chr2q37
GeneFamilyAquaporins

AQP12A AQP12B

4.06e-0414392305
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG4 VAV1

8.91e-0366392722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG4 DGKD VAV1

9.85e-03206393682
GeneFamilyOlfactory receptors, family 2

OR2T8 OR2A12

2.47e-02113392149
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

GPC1 FZD7 SLC6A8 PTDSS1 XXYLT1

3.49e-06184565ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
Diseasequinate measurement

NOX5 GRID1

3.27e-0415532EFO_0021167
Diseasesporadic amyotrophic lateral sclerosis

IQCF1 GRID1 ATP2B4

2.06e-03140533EFO_0001357
Diseasethioredoxin domain-containing protein 12 measurement

IQCF1 IQCF6

2.25e-0339532EFO_0008298
Diseaseprogression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma

GRID1 ATP2B4

2.25e-0339532EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Diseasecarbohydrate measurement

FUT6 ATP2B4

3.11e-0346532EFO_0004998

Protein segments in the cluster

PeptideGeneStartEntry
QKCRVCLAWLAWQNP

ABCF2

521

Q9UG63
EAICWQLLSRCFRSW

C1orf167

506

Q5SNV9
SLQDACWTLALCWAL

C1orf167

776

Q5SNV9
LLQAWKCVCNWASRL

CDRT15L2

256

A8MXV6
QAACTLMRLCWAWEL

AQP12A

111

Q8IXF9
MWQLWASLCCLLVLA

CTSB

1

P07858
QAACTLTRLCWAWEL

AQP12B

111

A6NM10
CTSLSLSQWLWCLFI

ATP2B4

1021

P23634
AALSACIIQCWWRLI

IQCF1

91

Q8N6M8
CIIQCWWRLILSKIL

IQCF1

96

Q8N6M8
RCLTWLRATWLAQVL

NOX5

291

Q96PH1
CLWVNVSAAGRWAVL

KCNMB1

76

Q16558
NWRVCTVLASTCWIF

OR2A12

136

Q8NGT7
LLNKWCWENWLAICR

nan

931

O00370
NLWECSARICALASW

LRRTM2

311

O43300
NARAWKRWCTQILSA

NRBP2

146

Q9NSY0
RGWWLLCAAAALVAC

GPC1

6

P35052
FSVLWLACVVLCVWW

JAG2

1091

Q9Y219
LLLLAAAWCLHWQRT

FLT3LG

196

P49771
WQLCLRMNLSCWLLG

OR2T8

136

A6NH00
LSAWVCGLLWTLCLL

MRGPRD

141

Q8TDS7
QCSCWAWFLLVLAVV

ADAMTSL2

6

Q86TH1
GQLKECTASAWLICW

GOLGA2P5

46

Q9HBQ8
SWGTCIRLAAACWLV

OR6Q1

141

Q8NGQ2
LNWWSTVCTSCKRLL

OTUD7A

186

Q8TE49
LRAWIIQCWWRQVLE

IQCF5

36

A8MTL0
LLQAALRAWVIQCWW

IQCF6

6

A8MYZ5
CLWLLAVALLPWTCA

PPT1

6

P50897
RFARLWVGVWSVLCC

FZD7

251

O75084
TIRVWNWQSRTCVCV

COPA

116

P53621
RWQLGRRLCQLWIAC

HTR5A

106

P47898
WSWRCCLTTLLFQLL

FUT6

11

P51993
CGSVLRLQDWRCLWC

DGKD

256

Q16760
MEALTLWLLPWICQC

GRID1

1

Q9ULK0
LWLLPWICQCVSVRA

GRID1

6

Q9ULK0
CLVAALELWWNSNRC

GRID1

846

Q9ULK0
RCAQVCWHWKNLAEL

FBXO16

111

Q8IX29
RRAAWLVCVAVWLAV

P2RY6

141

Q15077
AWCSIDWEQVCLLQR

MOS

51

P00540
ALCVWIWALAALASL

RXFP3

216

Q9NSD7
QLLRWAWSQWRECLA

SFI1

616

A8K8P3
AVAWVVLANQWPCRL

NKPD1

431

Q17RQ9
IRQECRWAWARCQDT

PLEKHG4

621

Q58EX7
ENRRCLLQCSVWQDW

NBEA

881

Q8NFP9
WLTICCAVWRSLPCR

FAM120AOS

141

Q5T036
RKWHFLCNCWLAVDL

PKD1L3

836

Q7Z443
CWNRLAQRYLIWECC

SCN5A

686

Q14524
LNWEVTLCLLACWVL

SLC6A8

231

P48029
GEIRWNLCLCLLLAW

SLC6A7

211

Q99884
LSASAIQEWCRQRWL

SLFNL1

356

Q499Z3
QRLCRLSVWIWQSVI

XKR6

231

Q5GH73
RQLWDELGALWVCII

ZSWIM5

411

Q9P217
QWVLCAAIWLVALVV

TMEM144

41

Q7Z5S9
VLLTLCGWVLCWTLV

TMEM39A

161

Q9NV64
CGWVLCWTLVNLFRS

TMEM39A

166

Q9NV64
MELWRQCTHWLIQCR

VAV1

1

P15498
KWILGVCQDCLLRNW

TRIM60

361

Q495X7
EAFSQLWELCCRWLR

ZNF213

61

O14771
CWQIWKQVASELTRC

ZNF227

116

Q86WZ6
AECWWDQVILDILLC

PTDSS1

211

P48651
HVLDCTWNRQLCTWW

XXYLT1

346

Q8NBI6
ALWVLGCCALLLSLW

LIME1

11

Q9H400