Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coregulator activity

MED15 SMARCD1 NCOA6 KMT2D SUPT20H MAML3 MED12

1.56e-05562307GO:0003712
GeneOntologyMolecularFunctiontranscription coactivator activity

SMARCD1 NCOA6 KMT2D MAML3 MED12

8.12e-05303305GO:0003713
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

NCOA6 MED12

3.29e-0418302GO:0042809
GeneOntologyMolecularFunctionmolecular adaptor activity

MED15 GIGYF2 SMARCD1 NCOA6 KMT2D SUPT20H MAML3 MED12

6.73e-041356308GO:0060090
GeneOntologyMolecularFunctionchromatin binding

SMARCD1 NCOA6 EP400 ATRX NFAT5 MED12

6.99e-04739306GO:0003682
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA6 MED12

1.19e-0334302GO:0046966
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

MED15 SMARCD1 NCOA6 KMT2D SUPT20H MAML3 MED12

1.37e-031160307GO:0030674
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

EP400 ATRX

1.41e-0337302GO:0140658
GeneOntologyBiologicalProcessDNA damage response

PAXIP1 FMN2 GIGYF2 SMARCD1 NCOA6 SUPT20H EP400 ATRX NFAT5 INTS7 EMSY

5.02e-089593011GO:0006974
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

PAXIP1 MED15 NCOA6 ZFHX3 KMT2D SUPT20H ATRX NFAT5 LMX1A MAML3 MED12 THAP11

2.32e-0713903012GO:0045944
GeneOntologyBiologicalProcesspositive regulation of DNA metabolic process

PAXIP1 CIZ1 FMN2 SMARCD1 EP400 ATRX

7.25e-06333306GO:0051054
GeneOntologyBiologicalProcessregulation of DNA metabolic process

PAXIP1 CIZ1 FMN2 SMARCD1 SUPT20H EP400 ATRX

1.30e-05564307GO:0051052
GeneOntologyBiologicalProcessDNA-templated transcription initiation

PAXIP1 MED15 SMARCD1 NCOA6 MED12

1.91e-05231305GO:0006352
GeneOntologyBiologicalProcessDNA repair

PAXIP1 FMN2 SMARCD1 SUPT20H EP400 ATRX EMSY

3.17e-05648307GO:0006281
GeneOntologyBiologicalProcessprotein-DNA complex organization

PAXIP1 MED15 SMARCD1 KMT2D EP400 ATRX NFAT5 EMSY

6.64e-05999308GO:0071824
GeneOntologyBiologicalProcessDNA metabolic process

PAXIP1 CIZ1 FMN2 SMARCD1 SUPT20H EP400 ATRX EMSY

1.15e-041081308GO:0006259
GeneOntologyBiologicalProcesspositive regulation of transcription initiation by RNA polymerase II

PAXIP1 MED15 MED12

1.42e-0470303GO:0060261
GeneOntologyBiologicalProcesstranscription initiation at RNA polymerase II promoter

PAXIP1 MED15 SMARCD1 MED12

1.46e-04186304GO:0006367
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription initiation

PAXIP1 MED15 MED12

1.89e-0477303GO:2000144
GeneOntologyBiologicalProcesssignal transduction in response to DNA damage

PAXIP1 GIGYF2 ATRX INTS7

1.93e-04200304GO:0042770
GeneOntologyBiologicalProcesspositive regulation of DNA-templated DNA replication

CIZ1 ATRX

2.12e-0415302GO:2000105
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

PAXIP1 MED15 MED12

2.19e-0481303GO:0060260
GeneOntologyBiologicalProcesscentral nervous system development

CACNA1A SHROOM4 GIGYF2 NCOA6 POU6F2 ATRX LMX1A MED12

2.33e-041197308GO:0007417
GeneOntologyBiologicalProcesschromatin organization

PAXIP1 SMARCD1 KMT2D EP400 ATRX NFAT5 EMSY

2.41e-04896307GO:0006325
GeneOntologyBiologicalProcessregulation of DNA-templated transcription initiation

PAXIP1 MED15 MED12

3.09e-0491303GO:2000142
GeneOntologyBiologicalProcessregulation of DNA repair

FMN2 SMARCD1 SUPT20H EP400

3.51e-04234304GO:0006282
GeneOntologyBiologicalProcesspositive regulation of double-strand break repair

FMN2 SMARCD1 EP400

3.51e-0495303GO:2000781
GeneOntologyBiologicalProcesschromatin remodeling

PAXIP1 SMARCD1 KMT2D EP400 ATRX NFAT5

5.98e-04741306GO:0006338
GeneOntologyBiologicalProcessspinal cord development

CACNA1A GIGYF2 MED12

6.78e-04119303GO:0021510
GeneOntologyBiologicalProcesslocomotory behavior

CACNA1A GIGYF2 ZFHX3 LMX1A

7.27e-04284304GO:0007626
GeneOntologyCellularComponentMLL3/4 complex

PAXIP1 NCOA6 KMT2D

5.24e-0712293GO:0044666
GeneOntologyCellularComponentnuclear protein-containing complex

PAXIP1 MED15 SMARCD1 NCOA6 KMT2D EP400 INTS7 MED12 THAP11

6.82e-051377299GO:0140513
GeneOntologyCellularComponentchromatin

SMARCD1 ZFHX3 POU6F2 SUPT20H EP400 ATRX NFAT5 LMX1A THAP11

1.19e-041480299GO:0000785
GeneOntologyCellularComponenthistone methyltransferase complex

PAXIP1 NCOA6 KMT2D

1.52e-0475293GO:0035097
GeneOntologyCellularComponentmethyltransferase complex

PAXIP1 NCOA6 KMT2D

4.44e-04108293GO:0034708
GeneOntologyCellularComponenttranscription regulator complex

MED15 NCOA6 ZFHX3 NFAT5 THAP11

1.25e-03596295GO:0005667
GeneOntologyCellularComponenttransferase complex

PAXIP1 NCOA6 KMT2D SUPT20H EP400 MED12

1.80e-03963296GO:1990234
DomainARM-like

NALF1 INTS7 MED12 THAP11

8.71e-04270304IPR011989
DomainZnF_U1

CIZ1 ZFHX3

9.86e-0429302SM00451
DomainZnf_U1

CIZ1 ZFHX3

9.86e-0429302IPR003604
DomainSNF2_N

EP400 ATRX

1.20e-0332302PF00176
DomainSNF2_N

EP400 ATRX

1.20e-0332302IPR000330
DomainHomeodomain-like

ZFHX3 POU6F2 EP400 LMX1A

1.87e-03332304IPR009057
DomainHomeobox

ZFHX3 POU6F2 LMX1A

6.14e-03234303PF00046
DomainHOMEOBOX_1

ZFHX3 POU6F2 LMX1A

6.29e-03236303PS00027
DomainHOX

ZFHX3 POU6F2 LMX1A

6.36e-03237303SM00389
DomainHomeobox_dom

ZFHX3 POU6F2 LMX1A

6.51e-03239303IPR001356
DomainHOMEOBOX_2

ZFHX3 POU6F2 LMX1A

6.51e-03239303PS50071
DomainZF_PHD_2

KMT2D ATRX

1.02e-0295302PS50016
Domain-

ZFHX3 POU6F2 LMX1A

1.03e-022833031.10.10.60
DomainZF_PHD_1

KMT2D ATRX

1.04e-0296302PS01359
DomainHelicase_C

EP400 ATRX

1.27e-02107302PF00271
DomainHELICc

EP400 ATRX

1.27e-02107302SM00490
DomainHelicase_C

EP400 ATRX

1.30e-02108302IPR001650
DomainHELICASE_CTER

EP400 ATRX

1.32e-02109302PS51194
DomainHELICASE_ATP_BIND_1

EP400 ATRX

1.32e-02109302PS51192
PathwayWP_KLEEFSTRA_SYNDROME

PAXIP1 SMARCD1 NCOA6

1.54e-0529243M48076
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

PAXIP1 NCOA6 KMT2D

4.77e-0542243M48018
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

KMT2D EP400 ATRX MED12 THAP11

1.31e-04301245MM15983
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

MED15 NCOA6 MED12

3.77e-0484243M1008
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

PAXIP1 SMARCD1 NCOA6 KMT2D

8.23e-04254244M27131
PathwayREACTOME_ADIPOGENESIS

MED15 NCOA6 MED12

8.30e-04110243M48259
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

MED15 NCOA6 MED12

1.02e-03118243M27316
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

SMARCD1 KMT2D SUPT20H EP400

1.06e-03272244M29619
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

PAXIP1 NCOA6 KMT2D

1.12e-03122243M29689
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

PAXIP1 KMT2D

1.88e-0338242MM17073
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

PAXIP1 MED15 GIGYF2 KMT2D EP400 MAML3 MED12

4.05e-17233079225980
Pubmed

Interaction network of human early embryonic transcription factors.

PAXIP1 MED15 SMARCD1 NCOA6 ZFHX3 KMT2D EP400 MED12 EMSY

1.16e-1135130938297188
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

PAXIP1 MED15 NCOA6 KMT2D EP400 EMSY

1.93e-116530622496869
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

PAXIP1 MED15 SMARCD1 NCOA6 KMT2D EP400 MED12 EMSY

5.66e-1126830833640491
Pubmed

Human transcription factor protein interaction networks.

PAXIP1 MED15 GIGYF2 SMARCD1 NCOA6 ZFHX3 KMT2D SUPT20H EP400 ATRX EMSY THAP11

9.62e-101429301235140242
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

MED15 SMARCD1 KMT2D EP400 MED12 EMSY

6.04e-0916730620362541
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CIZ1 MED15 GIGYF2 NCOA6 KMT2D EP400 MED12 EMSY

1.58e-0854930838280479
Pubmed

Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms.

NALF1 DENND4B THAP11

2.02e-0873038325628
Pubmed

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

PAXIP1 NCOA6 KMT2D

3.23e-08830317178841
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

PAXIP1 NCOA6 KMT2D

1.65e-071330317761849
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

SMARCD1 NCOA6 KMT2D EP400 ATRX

2.29e-0715730530186101
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PAXIP1 MED15 SMARCD1 NCOA6 KMT2D EP400 MED12 EMSY THAP11

2.47e-07110330934189442
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

PAXIP1 NCOA6 KMT2D

2.62e-071530317925232
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

AAK1 CIZ1 MED15 ZFHX3 SUPT20H EP400 ATRX INTS7 MED12 EMSY

2.89e-071497301031527615
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

PAXIP1 NCOA6 KMT2D

3.22e-071630324368734
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

MED15 KMT2D EP400 MED12

3.74e-076930428481362
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

PAXIP1 NCOA6 KMT2D

3.91e-071730326180087
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

PAXIP1 NCOA6 KMT2D EP400 MED12 EMSY

4.14e-0734130632971831
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

PAXIP1 NCOA6 KMT2D

4.68e-071830317500065
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

PAXIP1 NCOA6 KMT2D

6.54e-072030329785026
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

PAXIP1 NCOA6 KMT2D

6.54e-072030319047629
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

PAXIP1 NCOA6 KMT2D

8.82e-072230326886794
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PAXIP1 CIZ1 NCOA6 KMT2D SUPT20H EP400 ATRX INTS7 EMSY

9.38e-07129430930804502
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

PAXIP1 MED15 SMARCD1 NCOA6 KMT2D SIK3 MAML3

9.54e-0763830731182584
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

PAXIP1 CIZ1 MED15 KMT2D SUPT20H EP400

1.02e-0639830635016035
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

SMARCD1 ZFHX3 KMT2D ATRX MED12

1.21e-0622030535785414
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

PAXIP1 SUPT20H EP400 ATRX EMSY

1.27e-0622230537071664
Pubmed

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.

ATRX MED12

2.16e-06330226891131
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

AAK1 GIGYF2 NCOA6 KMT2D EP400 ATRX EMSY

3.43e-0677430715302935
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

NCOA6 ZFHX3 EP400 ATRX EMSY

4.15e-0628330530585729
Pubmed

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

PAXIP1 KMT2D

4.31e-06430230270123
Pubmed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

ZFHX3 SUPT20H ATRX

4.79e-063830328218735
Pubmed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

PAXIP1 KMT2D

7.18e-06530226744420
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

NCOA6 KMT2D

1.08e-05630217021013
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

PAXIP1 NCOA6 KMT2D

1.10e-055030337974198
Pubmed

Generation and analysis of 280,000 human expressed sequence tags.

GIGYF2 SMARCD1 SIK3 NALF1 NFAT5

1.48e-053683058889549
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

NCOA6 KMT2D

1.51e-05730219556342
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

PAXIP1 CIZ1 MED15 SUPT20H EP400 MED12

1.62e-0564530625281560
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

SMARCD1 NCOA6 MED12

1.82e-055930328813667
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

SMARCD1 ATRX MAML3 EMSY

1.83e-0518330436129980
Pubmed

Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development.

GIGYF2 LMX1A

2.01e-05830239117691
Pubmed

Behavioral effects of neonatal lesions on the cerebellar system.

CACNA1A LMX1A

2.01e-05830225907855
Pubmed

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

MED15 MED12

2.01e-05830223749998
Pubmed

Streamlined analysis schema for high-throughput identification of endogenous protein complexes.

MED15 INTS7 MED12

3.18e-057130320133760
Pubmed

Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.

ATRX MED12

3.22e-051030212777533
Pubmed

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

MED15 MED12

3.22e-051030223746844
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

AAK1 MED15 SUPT20H EP400 EMSY

3.63e-0544430534795231
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CIZ1 FMN2 SMARCD1 ZFHX3 SUPT20H SIK3 EP400

3.66e-05111630731753913
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

MED15 SMARCD1 EP400 MED12 EMSY

3.99e-0545330529656893
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

SMARCD1 NCOA6 KMT2D

4.22e-057830328611094
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

SMARCD1 C9orf43 KMT2D EP400 ATRX

4.71e-0546930527634302
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A FMN2 ATRX NFAT5 INTS7

5.00e-0547530531040226
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA6 KMT2D EP400

5.08e-058330328794006
Pubmed

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.

MED15 MED12

5.58e-051330214657022
Pubmed

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

KMT2D EP400

5.58e-051330216510874
Pubmed

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

MED15 MED12

5.58e-051330220098423
Pubmed

A genome-wide association study for reading and language abilities in two population cohorts.

ZFHX3 NALF1

5.58e-051330223738518
Pubmed

The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.

PAXIP1 KMT2D

5.58e-051330236395886
Pubmed

Structure, function, and activator-induced conformations of the CRSP coactivator.

MED15 MED12

6.50e-051430211834832
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

NCOA6 KMT2D

6.50e-051430212482968
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED15 MED12

7.50e-051530218418385
Pubmed

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

KMT2D EP400

7.50e-051530216510875
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

MED15 SMARCD1 SUPT20H ATRX INTS7

8.61e-0553330530554943
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

AAK1 CIZ1 MED15 GIGYF2 PDE5A ATRX THAP11

1.06e-04132130727173435
Pubmed

A census of human transcription factors: function, expression and evolution.

ZFHX3 POU6F2 KMT2D NFAT5 LMX1A THAP11

1.08e-0490830619274049
Pubmed

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

MED15 MED12 EMSY

1.08e-0410730320508642
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

PAXIP1 GIGYF2 SMARCD1 SUPT20H ATRX MED12 EMSY

1.09e-04132730732694731
Pubmed

Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival.

ZFHX3 LMX1A

1.09e-041830238912572
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED15 MED12

1.22e-041930216799563
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

AAK1 CIZ1 GIGYF2 EP400 ATRX EMSY

1.26e-0493430633916271
Pubmed

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

NCOA6 KMT2D

1.35e-042030232350066
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CIZ1 GIGYF2 NCOA6 EP400 ATRX EMSY

1.42e-0495430636373674
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

PAXIP1 NCOA6 KMT2D

1.48e-0411930323508102
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED15 MED12

1.80e-042330210235267
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MED15 SMARCD1 SUPT20H EP400 ATRX MED12

1.97e-04101430632416067
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

SMARCD1 SUPT20H EP400 EMSY

1.99e-0433930430415952
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

SUPT20H EP400 THAP11

2.10e-0413430325452129
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

AAK1 CACNA1A FMN2 GIGYF2

2.17e-0434730417114649
Pubmed

Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.

CACNA1A LMX1A

2.31e-042630235165395
Pubmed

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.

MED15 MED12

2.31e-042630234506481
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

NFAT5 EMSY

2.68e-042830229365100
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

MED15 MED12

2.68e-042830220720539
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SMARCD1 SUPT20H SIK3 EP400 MED12 THAP11

2.80e-04108230638697112
Pubmed

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.

POU6F2 LMX1A

3.08e-043030225804738
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PAXIP1 NCOA6 KMT2D EP400 MED12 THAP11

3.13e-04110530635748872
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

SMARCD1 ZFHX3 NFAT5 LMX1A MAML3

3.24e-0470930522988430
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

PAXIP1 KMT2D

3.29e-043130220516061
Pubmed

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

MED15 MED12

3.29e-043130223322298
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

CIZ1 SMARCD1 EP400 ATRX

3.52e-0439430427248496
Pubmed

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

MED15 MED12

3.97e-043430215989967
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

GIGYF2 EP400 NFAT5 DENND4B

3.98e-0440730412693553
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

KMT2D EP400 INTS7 MED12

4.09e-0441030426949251
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

GIGYF2 ZFHX3 KMT2D MED12

4.40e-0441830434709266
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

EP400 ATRX INTS7

4.76e-0417730326206133
Pubmed

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.

MED15 MED12

5.23e-043930238690566
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

NCOA6 MED12

5.78e-04413028724849
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

CIZ1 SMARCD1 ZFHX3 NFAT5 LMX1A

5.88e-0480830520412781
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

MED15 NCOA6 KMT2D MAML3

6.15e-0445730432344865
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

PAXIP1 SUPT20H MED12 THAP11

6.15e-0445730432968282
Pubmed

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

NCOA6 MED12

6.35e-044330226487511
InteractionFEV interactions

PAXIP1 NCOA6 ZFHX3 KMT2D SUPT20H EP400 ATRX EMSY

2.41e-10203288int:FEV
InteractionMED23 interactions

PAXIP1 MED15 NCOA6 ZFHX3 SUPT20H EP400 MED12 EMSY

2.05e-09266288int:MED23
InteractionSOX9 interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EP400 MED12

3.68e-0997286int:SOX9
InteractionHNF4A interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EP400 ATRX EMSY

7.56e-08275287int:HNF4A
InteractionEGR2 interactions

PAXIP1 NCOA6 ZFHX3 KMT2D EP400 EMSY

1.10e-07171286int:EGR2
InteractionHNF1B interactions

PAXIP1 SMARCD1 ZFHX3 POU6F2 KMT2D EP400

2.06e-07190286int:HNF1B
InteractionTP53BP1 interactions

PAXIP1 MED15 SMARCD1 NCOA6 POU6F2 EP400 MED12 EMSY

4.43e-07533288int:TP53BP1
InteractionAR interactions

PAXIP1 MED15 SMARCD1 NCOA6 ZFHX3 KMT2D EP400 ATRX MED12 EMSY

4.65e-079922810int:AR
InteractionELF4 interactions

SMARCD1 KMT2D SUPT20H EP400 EMSY

4.91e-07115285int:ELF4
InteractionNFIX interactions

PAXIP1 SMARCD1 ZFHX3 KMT2D EP400 EMSY

5.85e-07227286int:NFIX
InteractionETS1 interactions

PAXIP1 SMARCD1 KMT2D EP400 EMSY

6.32e-07121285int:ETS1
InteractionPAX9 interactions

PAXIP1 SMARCD1 NCOA6 ZFHX3 KMT2D

9.02e-07130285int:PAX9
InteractionTPRX2 interactions

PAXIP1 SMARCD1 NCOA6 KMT2D

1.04e-0656284int:TPRX2
InteractionCRX interactions

PAXIP1 MED15 ZFHX3 KMT2D EP400 MED12

1.13e-06254286int:CRX
InteractionESRRB interactions

MED15 SMARCD1 KMT2D EP400 INTS7 MED12

1.35e-06262286int:ESRRB
InteractionELF5 interactions

PAXIP1 SMARCD1 KMT2D INTS7 EMSY

1.66e-06147285int:ELF5
InteractionTLX3 interactions

PAXIP1 SMARCD1 NCOA6 ZFHX3 POU6F2 KMT2D

2.48e-06291286int:TLX3
InteractionHCFC1 interactions

PAXIP1 MED15 NCOA6 KMT2D EP400 THAP11

2.58e-06293286int:HCFC1
InteractionCEBPA interactions

PAXIP1 MED15 SMARCD1 NCOA6 KMT2D EP400 INTS7 MED12 EMSY THAP11

3.67e-0612452810int:CEBPA
InteractionFOS interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EP400 NFAT5

3.71e-06312286int:FOS
InteractionLHX2 interactions

PAXIP1 SMARCD1 ZFHX3 KMT2D EP400

4.85e-06183285int:LHX2
InteractionMEN1 interactions

PAXIP1 GIGYF2 SMARCD1 NCOA6 KMT2D EP400 ATRX MED12 EMSY

6.52e-061029289int:MEN1
InteractionKLF5 interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EP400

6.61e-06195285int:KLF5
InteractionMAFA interactions

PAXIP1 NCOA6 KMT2D

6.87e-0627283int:MAFA
InteractionTADA2A interactions

PAXIP1 MED15 SUPT20H MED12 EMSY

7.12e-06198285int:TADA2A
InteractionGATA2 interactions

PAXIP1 SMARCD1 NCOA6 ZFHX3 KMT2D

7.29e-06199285int:GATA2
InteractionSOX10 interactions

PAXIP1 SMARCD1 POU6F2 KMT2D

7.66e-0692284int:SOX10
InteractionSOX17 interactions

PAXIP1 SMARCD1 NCOA6 KMT2D

8.70e-0695284int:SOX17
InteractionPAX6 interactions

PAXIP1 SMARCD1 NCOA6 ZFHX3 KMT2D EP400

9.25e-06366286int:PAX6
InteractionHDAC1 interactions

GIGYF2 SMARCD1 ZFHX3 KMT2D EP400 ATRX MED12 EMSY THAP11

1.19e-051108289int:HDAC1
InteractionERG interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EMSY

1.27e-05223285int:ERG
InteractionSUPT5H interactions

PDE5A KMT2D EP400 ATRX INTS7 MAML3

1.71e-05408286int:SUPT5H
InteractionTBR1 interactions

PAXIP1 SMARCD1 ZFHX3 KMT2D

1.73e-05113284int:TBR1
InteractionNUP43 interactions

CIZ1 NCOA6 ZFHX3 KMT2D EP400 MED12 EMSY

1.79e-05625287int:NUP43
InteractionTBXT interactions

PAXIP1 SMARCD1 NCOA6 KMT2D

1.92e-05116284int:TBXT
InteractionASF1A interactions

NCOA6 KMT2D EP400 ATRX EMSY

2.15e-05249285int:ASF1A
InteractionFBXW7 interactions

PAXIP1 MED15 SHROOM4 GIGYF2 NCOA6 KMT2D EP400 MED12 THAP11

2.48e-051215289int:FBXW7
InteractionPAX7 interactions

PAXIP1 SMARCD1 ZFHX3 KMT2D

2.49e-05124284int:PAX7
InteractionPML interactions

PAXIP1 AAK1 MED15 SUPT20H EP400 ATRX INTS7 EMSY

2.78e-05933288int:PML
InteractionMYB interactions

PAXIP1 ZFHX3 KMT2D EMSY

3.28e-05133284int:MYB
InteractionTLX2 interactions

PAXIP1 ZFHX3 POU6F2 KMT2D

4.24e-05142284int:TLX2
InteractionRBBP5 interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EMSY

4.25e-05287285int:RBBP5
InteractionNCOA6 interactions

PAXIP1 MED15 NCOA6 KMT2D

4.60e-05145284int:NCOA6
InteractionPAGR1 interactions

PAXIP1 NCOA6 KMT2D

4.78e-0551283int:PAGR1
InteractionSP7 interactions

PAXIP1 SMARCD1 NCOA6 KMT2D EP400

5.59e-05304285int:SP7
InteractionPPARG interactions

PAXIP1 GIGYF2 SMARCD1 NCOA6 KMT2D

5.85e-05307285int:PPARG
InteractionYAP1 interactions

CIZ1 MED15 GIGYF2 SMARCD1 NCOA6 KMT2D NFAT5 MED12

8.67e-051095288int:YAP1
InteractionTLX1 interactions

PAXIP1 SMARCD1 ZFHX3 KMT2D

9.56e-05175284int:TLX1
InteractionTEAD1 interactions

PAXIP1 SMARCD1 ZFHX3 KMT2D

9.77e-05176284int:TEAD1
InteractionGCM1 interactions

PAXIP1 SMARCD1 KMT2D

1.13e-0468283int:GCM1
InteractionLHX3 interactions

PAXIP1 SMARCD1 KMT2D LMX1A

1.18e-04185284int:LHX3
InteractionNFIA interactions

PAXIP1 MED15 SMARCD1 KMT2D

1.26e-04188284int:NFIA
InteractionMYOD1 interactions

PAXIP1 SMARCD1 KMT2D EP400

1.42e-04194284int:MYOD1
InteractionSETD1B interactions

PAXIP1 NCOA6 KMT2D

1.52e-0475283int:SETD1B
InteractionXKRX interactions

SIK3 ATRX

1.68e-0414282int:XKRX
InteractionIRF4 interactions

PAXIP1 SMARCD1 KMT2D

2.20e-0485283int:IRF4
InteractionGSC interactions

PAXIP1 ZFHX3 KMT2D

2.35e-0487283int:GSC
InteractionKLF3 interactions

ZFHX3 KMT2D EP400 EMSY

2.64e-04228284int:KLF3
InteractionFOXI1 interactions

PAXIP1 SMARCD1 KMT2D

2.78e-0492283int:FOXI1
InteractionMED7 interactions

MED15 EP400 MED12

2.78e-0492283int:MED7
InteractionHCFC2 interactions

PAXIP1 NCOA6 KMT2D

2.78e-0492283int:HCFC2
InteractionNR3C1 interactions

PAXIP1 MED15 SMARCD1 NCOA6 KMT2D SIK3 MAML3

2.92e-04974287int:NR3C1
InteractionKLF6 interactions

SUPT20H EP400 EMSY

3.05e-0495283int:KLF6
InteractionTFCP2L1 interactions

SMARCD1 EP400 EMSY

3.45e-0499283int:TFCP2L1
InteractionLHX1 interactions

SMARCD1 KMT2D SUPT20H

3.87e-04103283int:LHX1
InteractionUTY interactions

NCOA6 KMT2D

4.63e-0423282int:UTY
InteractionASH2L interactions

PAXIP1 NCOA6 KMT2D EMSY

4.67e-04265284int:ASH2L
InteractionEN1 interactions

PAXIP1 KMT2D EP400

4.69e-04110283int:EN1
InteractionPAX8 interactions

PAXIP1 SMARCD1 KMT2D

4.82e-04111283int:PAX8
InteractionRELA interactions

MED15 NCOA6 ZFHX3 POU6F2 KMT2D

4.92e-04485285int:RELA
InteractionPLAC1 interactions

SUPT20H EP400

5.04e-0424282int:PLAC1
InteractionRCOR1 interactions

GIGYF2 ZFHX3 KMT2D MED12 THAP11

5.35e-04494285int:RCOR1
InteractionZNF335 interactions

NCOA6 EMSY

5.48e-0425282int:ZNF335
InteractionTNRC6A interactions

GIGYF2 SMARCD1 NCOA6 MED12

5.74e-04280284int:TNRC6A
InteractionELK3 interactions

SUPT20H EP400 EMSY

6.05e-04120283int:ELK3
InteractionTRRAP interactions

MED15 SUPT20H EP400 INTS7 MED12 THAP11

6.40e-04790286int:TRRAP
InteractionKLF15 interactions

MED15 KMT2D EP400 EMSY

6.55e-04290284int:KLF15
InteractionGET3 interactions

CACNA1A ZFHX3 EMSY

7.64e-04130283int:GET3
InteractionKMT2B interactions

PAXIP1 NCOA6 KMT2D

7.64e-04130283int:KMT2B
InteractionMED15 interactions

MED15 NCOA6 MED12

7.81e-04131283int:MED15
InteractionCXXC1 interactions

PAXIP1 NCOA6 KMT2D

7.98e-04132283int:CXXC1
InteractionKMT2C interactions

PAXIP1 NCOA6 KMT2D

8.34e-04134283int:KMT2C
InteractionKMT2A interactions

PAXIP1 MED15 NCOA6 KMT2D

8.81e-04314284int:KMT2A
InteractionNR1H4 interactions

SMARCD1 NCOA6

9.00e-0432282int:NR1H4
InteractionNFIB interactions

PAXIP1 SMARCD1 KMT2D

9.86e-04142283int:NFIB
InteractionRNF2 interactions

PAXIP1 MED15 NCOA6 KMT2D EP400 EMSY

1.03e-03866286int:RNF2
InteractionSLX4 interactions

PAXIP1 SUPT20H EP400 ATRX EMSY

1.04e-03572285int:SLX4
InteractionKLF8 interactions

KMT2D SUPT20H EP400 EMSY

1.05e-03329284int:KLF8
InteractionBOD1L1 interactions

PAXIP1 NCOA6 KMT2D

1.13e-03149283int:BOD1L1
InteractionPOU5F1 interactions

PAXIP1 GIGYF2 ZFHX3 EP400 EMSY

1.14e-03584285int:POU5F1
InteractionZBTB4 interactions

POU6F2 ATRX

1.14e-0336282int:ZBTB4
InteractionPPIA interactions

PAXIP1 SHROOM4 SMARCD1 NCOA6 EP400 MED12

1.18e-03888286int:PPIA
InteractionPHF21A interactions

GIGYF2 ZFHX3 KMT2D THAP11

1.22e-03343284int:PHF21A
InteractionDLL1 interactions

POU6F2 THAP11

1.27e-0338282int:DLL1
InteractionH3C14 interactions

NCOA6 KMT2D ATRX

1.29e-03156283int:H3C14
InteractionCCT8L2 interactions

CIZ1 ATRX THAP11

1.32e-03157283int:CCT8L2
InteractionKDM6A interactions

PAXIP1 NCOA6 KMT2D

1.44e-03162283int:KDM6A
InteractionUPF2 interactions

CIZ1 GIGYF2 SMARCD1

1.44e-03162283int:UPF2
InteractionPAXIP1 interactions

PAXIP1 NCOA6 KMT2D INTS7

1.45e-03359284int:PAXIP1
InteractionXRCC6 interactions

PAXIP1 NCOA6 ZFHX3 EP400 ATRX EMSY

1.48e-03928286int:XRCC6
CytobandEnsembl 112 genes in cytogenetic band chr16q22

ZFHX3 NFAT5 THAP11

2.34e-04183303chr16q22
GeneFamilyAtaxins|Trinucleotide repeat containing

PAXIP1 MED15 GIGYF2 KMT2D EP400 MAML3 MED12

4.41e-1625217775
GeneFamilyCyclins|Mediator complex

MED15 MED12

6.64e-04332121061
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

PAXIP1 CIZ1 NCOA6 SUPT20H ATRX NFAT5 INTS7 DENND4B

4.89e-051215308M41122
CoexpressionGSE14308_TH17_VS_INDUCED_TREG_UP

SUPT20H SIK3 ATRX NFAT5

7.72e-05200304M3385
CoexpressionGSE411_100MIN_VS_400MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_DN

CIZ1 KMT2D SUPT20H MED12

7.72e-05200304M5995
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000

PDE5A NCOA6 ZFHX3 POU6F2 SIK3 ATRX MAML3 EMSY

4.90e-05985308Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

CIZ1 MED15 CACNA1A EMSY

6.83e-06184304ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FMN2 POU6F2 NALF1 MAML3

6.98e-0618530434fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FMN2 POU6F2 NALF1 MAML3

6.98e-061853048816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A FMN2 PDE5A ATRX

8.58e-061953043e519cffa6144a62b06124642a14c9ff39b76554
ToppCell368C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SHROOM4 ZNF853 LMX1A

1.35e-041493039286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell368C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SHROOM4 ZNF853 LMX1A

1.35e-04149303f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FMN2 PDE5A ZFHX3

1.44e-041523030cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FMN2 PDE5A ZFHX3

1.44e-04152303ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 LMX1A MAML3

1.80e-0416430343630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 LMX1A MAML3

1.80e-0416430346208f18325976c89f572f6627aea0582142b92d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 LMX1A MAML3

1.80e-04164303108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A POU6F2 LMX1A

1.83e-041653034b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A PDE5A ZFHX3

2.10e-04173303fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A PDE5A ZFHX3

2.10e-04173303901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A FMN2 LMX1A

2.17e-04175303182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

CACNA1A FMN2 NALF1

2.17e-041753034db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

CACNA1A FMN2 NALF1

2.17e-041753038d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A FMN2 LMX1A

2.21e-04176303fb718a6b07aa5d56600263280afa530bcb63db42
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAXIP1 MED15 PDE5A

2.29e-04178303fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

FMN2 POU6F2 NALF1

2.29e-04178303544379f5a6145429762258d426b876bb36c112f5
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

SHROOM4 NCOA6 ZNF853

2.29e-04178303edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A FMN2 LMX1A

2.29e-0417830330ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A FMN2 LMX1A

2.32e-04179303f2e8fc975c30992611630197b79daaeef7c4211d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FMN2 POU6F2 MAML3

2.48e-04183303848fc6dd129150897ee339343e83c645b6e779eb
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

CACNA1A PDE5A NALF1

2.48e-04183303cae2ee08f985a6f005b4b8e959e465350315156a
ToppCellControl-immature_Neutrophil-|Control / Disease condition and Cell class

MED15 CACNA1A EMSY

2.52e-04184303c4e8ba82a6aa76c46f05a71d5f1c7926555318cf
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED15 CACNA1A EMSY

2.52e-04184303a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED15 CACNA1A EMSY

2.52e-04184303081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellControl-Myeloid_G-immature_Neutrophil|Control / Disease group, lineage and cell class

MED15 CACNA1A EMSY

2.52e-0418430345f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCellControl-immature_Neutrophil|Control / Disease condition and Cell class

MED15 CACNA1A EMSY

2.52e-041843032fdae5c6b3eb2232881d933a8c1061fda3623016
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A NALF1 LMX1A

2.52e-041843037d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MED15 CACNA1A EMSY

2.52e-0418430384c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MED15 CACNA1A EMSY

2.52e-04184303d31d4116d1d196633784863781fa45673607a421
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

KMT2D NFAT5 DENND4B

2.56e-04185303a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

GIGYF2 ATRX NFAT5

2.60e-0418630303db813598b67b1e08f759758a1c2023396921fa
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POU6F2 NALF1 MAML3

2.68e-04188303874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POU6F2 NALF1 MAML3

2.68e-04188303b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SIK3 NFAT5 MAML3

2.90e-04193303779276e775cb2492e8dd36436295a536084a6415
ToppCellControl-NK_CD56bright|Control / Disease condition and Cell class

ZFHX3 ZNF853 MAML3

2.90e-041933038b1e7a226a6057e1097c1525984127b54e823876
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE5A ZFHX3 NALF1

2.94e-04194303ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE5A ZFHX3 NALF1

2.94e-041943035c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAXIP1 PDE5A NALF1

2.99e-04195303bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FMN2 POU6F2 NALF1

2.99e-041953032e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A FMN2 ATRX

2.99e-041953037796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A FMN2 MAML3

3.08e-04197303ff4df77117165b6b25315e29b0722cc136eba607
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A NALF1 ZNF853

3.12e-04198303d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A FMN2 NALF1

3.12e-041983036d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A FMN2 NALF1

3.12e-04198303c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A FMN2 NALF1

3.12e-041983034ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

CIZ1 MED15 SMARCD1

3.22e-04200303ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCellTCGA-Bile_Duct-Primary_Tumor|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

CIZ1 MED15 SMARCD1

3.22e-042003030350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

AAK1 CACNA1A NALF1

3.22e-0420030348d801219bc771d6c7e151dc88ca4c179988de85
ComputationalNeighborhood of ATRX

PAXIP1 POU6F2 SIK3 EP400 ATRX

6.10e-05215225MORF_ATRX
ComputationalNeighborhood of MSH3

PAXIP1 POU6F2 EP400 ATRX NFAT5

1.09e-04243225MORF_MSH3
ComputationalNeighborhood of BRCA1

PAXIP1 POU6F2 EP400 ATRX NFAT5

1.58e-04263225MORF_BRCA1
ComputationalNeighborhood of CDC2L5

PAXIP1 SIK3 EP400 ATRX

1.77e-04142224MORF_CDC2L5
ComputationalNeighborhood of REV3L

PAXIP1 EP400 ATRX

2.13e-0458223MORF_REV3L
ComputationalNeighborhood of RUNX1

PAXIP1 POU6F2 EP400 ATRX

2.31e-04152224MORF_RUNX1
ComputationalNeighborhood of FANCG

PAXIP1 KMT2D SIK3 ATRX

3.30e-04167224MORF_FANCG
ComputationalNeighborhood of PSMF1

PAXIP1 POU6F2 EP400 ATRX

3.30e-04167224MORF_PSMF1
ComputationalNeighborhood of RFC5

PAXIP1 EP400 ATRX

5.13e-0478223MORF_RFC5
ComputationalNeighborhood of PPP5C

PAXIP1 EP400 ATRX

8.05e-0491223MORF_PPP5C
ComputationalNeighborhood of BCL2

PAXIP1 AAK1 POU6F2 ATRX

9.83e-04223224MORF_BCL2
ComputationalNeighborhood of ERCC2

PAXIP1 SIK3 ATRX

1.19e-03104223MORF_ERCC2
ComputationalNeighborhood of MT4

PAXIP1 AAK1 SIK3 ATRX

1.44e-03247224MORF_MT4
DrugDipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; HL60; HG-U133A

CIZ1 MED15 SIK3 EP400 DENND4B

3.55e-061803051752_UP
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA

MED15 SUPT20H EP400 NFAT5 MED12

5.11e-061943051060_UP
Drugthiochrome

CACNA1A NCOA6

1.10e-0412302CID000066706
DrugCitalopram hydrobromide [59729-32-7]; Down 200; 1uM; MCF7; HT_HG-U133A

NALF1 ATRX NFAT5 EMSY

1.18e-041943043903_DN
DrugPyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; HL60; HG-U133A

CIZ1 MED15 EP400 MED12

1.18e-041943041759_UP
Drugtroglitazone; Down 200; 10uM; MCF7; HT_HG-U133A

MED15 SUPT20H INTS7 DENND4B

1.20e-041953041657_DN
DrugCefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; PC3; HT_HG-U133A

SMARCD1 NFAT5 INTS7 EMSY

1.22e-041963042072_UP
DrugIsoetharine mesylate salt [7279-75-6]; Down 200; 12uM; PC3; HT_HG-U133A

SUPT20H ATRX NFAT5 MED12

1.22e-041963045812_DN
DrugZidovudine, AZT [30516-87-1]; Down 200; 15uM; HL60; HG-U133A

AAK1 MED15 EP400 INTS7

1.27e-041983041595_DN
DrugOxybutynin chloride [1508-65-2]; Up 200; 10.2uM; PC3; HT_HG-U133A

AAK1 ZFHX3 SUPT20H NFAT5

1.27e-041983047126_UP
DrugUngerine nitrate; Up 200; 10.2uM; HL60; HT_HG-U133A

AAK1 SMARCD1 KMT2D NALF1

1.30e-041993042514_UP
DrugAcyclovir [59277-89-3]; Down 200; 17.8uM; PC3; HG-U133A

AAK1 CIZ1 SMARCD1 SUPT20H

1.30e-041993041960_DN
DrugSotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A

MED15 SMARCD1 MED12 EMSY

1.30e-041993047338_DN
DrugConvolamine hydrochloride [500-56-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

CIZ1 MED15 ZFHX3 EMSY

1.30e-041993045876_DN
DrugAlfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; HL60; HG-U133A

AAK1 CIZ1 SUPT20H MED12

1.30e-041993041586_DN
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; PC3; HT_HG-U133A

MED15 SUPT20H NALF1 EP400

1.32e-042003046333_DN
DrugDiflunisal [22494-42-4]; Up 200; 16uM; PC3; HG-U133A

CIZ1 SMARCD1 NFAT5 INTS7

1.32e-042003041908_UP
DiseasePhyllodes Tumor

KMT2D MED12

9.97e-065302C0010701
DiseaseMalignant Cystosarcoma Phyllodes

KMT2D MED12

9.97e-065302C0600066
Diseasetotal cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer

ZFHX3 SIK3 MAML3

4.75e-0569303EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Diseasealcohol consumption measurement

CACNA1A ZFHX3 POU6F2 TMEM229A NALF1 NFAT5 LMX1A

2.00e-041242307EFO_0007878
Diseasetea consumption measurement

ZFHX3 POU6F2 NFAT5

3.04e-04129303EFO_0010091
Diseaselung small cell carcinoma (is_implicated_in)

KMT2D ATRX

3.72e-0428302DOID:5409 (is_implicated_in)
Diseasecalcium measurement

AAK1 NCOA6 ZFHX3 SIK3 LMX1A

3.94e-04628305EFO_0004838
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

ZFHX3 POU6F2 NFAT5 MAML3

4.84e-04364304EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseBorderline personality disorder

NALF1 MAML3

5.82e-0435302HP_0012076
DiseaseMalignant neoplasm of breast

SMARCD1 NCOA6 KMT2D SIK3 MED12 EMSY

6.43e-041074306C0006142
Diseasedepressive symptom measurement

CACNA1A POU6F2 MAML3 MED12

8.72e-04426304EFO_0007006
Diseaseunipolar depression

GIGYF2 ZFHX3 TMEM229A NALF1 MAML3 MED12

1.18e-031206306EFO_0003761
Diseasebody fat percentage

ZFHX3 POU6F2 NFAT5 MAML3

1.44e-03488304EFO_0007800
DiseasePROSTATE CANCER, HEREDITARY, 1

EMSY DENND4B

1.71e-0360302C4722327
Diseaseurate measurement

AAK1 FMN2 NCOA6 NFAT5 INTS7

1.93e-03895305EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
QQQQQQQQQQAVARP

CACNA1A

2316

O00555
FQLLRQQQQQQQQQQ

EP400

2751

Q96L91
QLMQNFYQQQQQQQQ

AAK1

526

Q2M2I8
LQQQQAQQPLQQQQQ

INTS7

941

Q9NVH2
QLQQQQQQQISQQPY

PAXIP1

426

Q6ZW49
QQFLREQRQQQQQQQ

MAML3

756

Q96JK9
RQQQQQQDQQNTQRL

LMX1A

256

Q8TE12
QRQQQQPQQQKQQQR

PDE5A

11

O76074
QQVALQQQQQQQQFQ

MED15

156

Q96RN5
QNQQQIQQQQQQLQR

MED15

226

Q96RN5
IAQLQLQQQQQQQQQ

MED15

241

Q96RN5
QQQQQQQQQQQYHIR

MED12

2066

Q93074
QQQQQQYHIRQQQQQ

MED12

2071

Q93074
QQQQQQILRQQQQQQ

MED12

2081

Q93074
QILRQQQQQQQQQQQ

MED12

2086

Q93074
QFQRQGLQQTQQQQQ

MED12

2136

Q93074
QQQQQQQQQQQSILF

NFAT5

1256

O94916
QQQQQQQQQQLQARP

NCOA6

276

Q14686
NRRLQQQYNQQQQQQ

ATRX

2411

P46100
NQQRQQQQLPQQQQQ

GIGYF2

1201

Q6Y7W6
RKQQQRQQQQQQQQK

C9orf43

291

Q8TAL5
LRERQQQQQQQQQQQ

DENND4B

891

O75064
QLYQVQQQTQQQVAQ

EMSY

411

Q7Z589
QQQQQQQLQLQLQQQ

FMN2

206

Q9NZ56
QQLQLQLQQQQQQQQ

FMN2

211

Q9NZ56
QQIQQVQQQAVQNRN

SMARCD1

106

Q96GM5
RRRQQQQQQQQQQQQ

TMEM229A

186

B2RXF0
QQQQQQQQQQRRGAL

TMEM229A

191

B2RXF0
QLQLQLQQQQQQQQQ

POU6F2

181

P78424
IKRQQQQRQQQQQQQ

SIK3

996

Q9Y2K2
RAAQQQKQQQQQQKQ

SHROOM4

1116

Q9ULL8
QQQQLQQQQQQLQQL

CIZ1

6

Q9ULV3
QQQQQQLQQLQQQQL

CIZ1

11

Q9ULV3
QQQQLQQQQLQQQQL

CIZ1

21

Q9ULV3
RQQQLQQQQQQGNKT

SOGA3

71

Q5TF21
FQQQQQQIQQLRFLQ

SUPT20H

726

Q8NEM7
QQLLQQQQEQLQQQQ

ZNF853

201

P0CG23
QQQEQLQQQQLLQQQ

ZNF853

206

P0CG23
LLQQQEQLQQQQFQQ

ZNF853

216

P0CG23
EQLQQQQFQQQQEQL

ZNF853

221

P0CG23
QQQEQLQQQQQQQLL

ZNF853

281

P0CG23
LQQQQQQQLLQQQQE

ZNF853

286

P0CG23
QQQLLQQQQEQLQQQ

ZNF853

291

P0CG23
RRRQQQQQQQQQQQQ

THAP11

101

Q96EK4
QQQQQRQLQQQQQQK

ZFHX3

3376

Q15911
RQLQQQQQQKVQQQQ

ZFHX3

3381

Q15911
LQQQQQLQQQQQQQL

KMT2D

3906

O14686
LQQQQLQQQQQQQQL

KMT2D

3926

O14686
QRQQQQQQQQQRQRQ

NALF1

76

B1AL88