Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1E	7.80e-05	9	30	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1E	7.80e-05	9	30	2	GO:0099626
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1E	1.96e-04	14	30	2	GO:0008331
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1E GRIN2D	9.41e-04	129	30	3	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1A CACNA1E GRIN2D	1.48e-03	151	30	3	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1A CACNA1E GRIN2D	1.51e-03	152	30	3	GO:0022843
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1E	2.17e-03	46	30	2	GO:0005245
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1A CACNA1E GRIN2D	2.52e-03	182	30	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1A CACNA1E GRIN2D	2.60e-03	184	30	3	GO:0022832
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	6.13e-06	3	30	2	GO:0002879
GeneOntologyBiologicalProcess	tendon cell differentiation	BMP4 GDF7	1.22e-05	4	30	2	GO:0035990
GeneOntologyBiologicalProcess	tendon formation	BMP4 GDF7	1.22e-05	4	30	2	GO:0035992
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.22e-05	4	30	2	GO:0002877
GeneOntologyBiologicalProcess	regulation of hormone biosynthetic process	CACNA1A FFAR3 GPR42	1.92e-05	36	30	3	GO:0046885
GeneOntologyBiologicalProcess	transmission of nerve impulse	CACNA1A CACNA1E FFAR3 GPR42	2.02e-05	112	30	4	GO:0019226
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	2.04e-05	5	30	2	GO:0002525
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	3.06e-05	6	30	2	GO:1904457
GeneOntologyBiologicalProcess	tendon development	BMP4 GDF7	4.28e-05	7	30	2	GO:0035989
GeneOntologyBiologicalProcess	regulation of heart rate by chemical signal	FFAR3 GPR42	7.32e-05	9	30	2	GO:0003062
GeneOntologyBiologicalProcess	regulation of hormone metabolic process	CACNA1A FFAR3 GPR42	8.12e-05	58	30	3	GO:0032350
GeneOntologyBiologicalProcess	negative regulation of insulin secretion	FBN1 FFAR3 GPR42	9.91e-05	62	30	3	GO:0046676
GeneOntologyBiologicalProcess	glucose homeostasis	CACNA1A CACNA1E FBN1 FFAR3 GPR42	1.17e-04	338	30	5	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	CACNA1A CACNA1E FBN1 FFAR3 GPR42	1.18e-04	339	30	5	GO:0033500
GeneOntologyBiologicalProcess	positive regulation of transmission of nerve impulse	FFAR3 GPR42	1.58e-04	13	30	2	GO:0051971
GeneOntologyBiologicalProcess	negative regulation of peptide hormone secretion	FBN1 FFAR3 GPR42	1.61e-04	73	30	3	GO:0090278
GeneOntologyBiologicalProcess	negative regulation of peptide secretion	FBN1 FFAR3 GPR42	1.75e-04	75	30	3	GO:0002792
GeneOntologyBiologicalProcess	regulation of neuronal action potential	FFAR3 GPR42	2.12e-04	15	30	2	GO:0098908
GeneOntologyBiologicalProcess	hormone biosynthetic process	CACNA1A FFAR3 GPR42	2.36e-04	83	30	3	GO:0042446
GeneOntologyBiologicalProcess	response to BMP	BMP4 FBN1 GDF7 ADAMTS7	2.54e-04	215	30	4	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	BMP4 FBN1 GDF7 ADAMTS7	2.54e-04	215	30	4	GO:0071773
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	CACNA1A CACNA1E BMP4 GRIN2D	2.63e-04	217	30	4	GO:0097553
GeneOntologyBiologicalProcess	positive regulation of action potential	FFAR3 GPR42	3.08e-04	18	30	2	GO:0045760
GeneOntologyBiologicalProcess	regulation of insulin secretion	CACNA1E FBN1 FFAR3 GPR42	3.34e-04	231	30	4	GO:0050796
GeneOntologyBiologicalProcess	negative regulation of hormone secretion	FBN1 FFAR3 GPR42	4.45e-04	103	30	3	GO:0046888
GeneOntologyBiologicalProcess	negative regulation of protein secretion	FBN1 FFAR3 GPR42	4.45e-04	103	30	3	GO:0050709
GeneOntologyBiologicalProcess	bone development	BMP4 FBN1 ADAMTS7 LRRC17	5.53e-04	264	30	4	GO:0060348
GeneOntologyBiologicalProcess	insulin secretion	CACNA1E FBN1 FFAR3 GPR42	6.36e-04	274	30	4	GO:0030073
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	CACNA1A LARP1 FBN1 GRIN2D FFAR3 GPR42	6.46e-04	752	30	6	GO:1901699
GeneOntologyBiologicalProcess	regulation of norepinephrine secretion	FFAR3 GPR42	6.50e-04	26	30	2	GO:0014061
GeneOntologyBiologicalProcess	regulation of peptide hormone secretion	CACNA1E FBN1 FFAR3 GPR42	6.62e-04	277	30	4	GO:0090276
GeneOntologyBiologicalProcess	negative regulation of chondrocyte differentiation	BMP4 ADAMTS7	7.02e-04	27	30	2	GO:0032331
GeneOntologyBiologicalProcess	regulation of peptide transport	CACNA1E FBN1 FFAR3 GPR42	7.08e-04	282	30	4	GO:0090087
GeneOntologyBiologicalProcess	regulation of peptide secretion	CACNA1E FBN1 FFAR3 GPR42	7.08e-04	282	30	4	GO:0002791
GeneOntologyBiologicalProcess	norepinephrine secretion	FFAR3 GPR42	7.55e-04	28	30	2	GO:0048243
GeneOntologyBiologicalProcess	regulation of transmission of nerve impulse	FFAR3 GPR42	7.55e-04	28	30	2	GO:0051969
GeneOntologyBiologicalProcess	regulation of amine transport	CACNA1A FFAR3 GPR42	7.83e-04	125	30	3	GO:0051952
GeneOntologyBiologicalProcess	morphogenesis of an epithelial fold	BMP4 GDF7	8.10e-04	29	30	2	GO:0060571
GeneOntologyBiologicalProcess	cellular response to oxygen-containing compound	CACNA1A LARP1 CACNA1E BMP4 FBN1 GRIN2D FFAR3 GPR42	8.46e-04	1450	30	8	GO:1901701
GeneOntologyBiologicalProcess	regulation of heart rate	CACNA1E FFAR3 GPR42	8.58e-04	129	30	3	GO:0002027
GeneOntologyBiologicalProcess	behavioral response to pain	CACNA1A CACNA1E	9.87e-04	32	30	2	GO:0048266
GeneOntologyBiologicalProcess	amine transport	CACNA1A FFAR3 GPR42	1.02e-03	137	30	3	GO:0015837
GeneOntologyBiologicalProcess	regulation of protein transport	CACNA1E BMP4 FBN1 FFAR3 GPR42	1.18e-03	560	30	5	GO:0051223
GeneOntologyBiologicalProcess	organic cation transport	CACNA1A FFAR3 GPR42	1.20e-03	145	30	3	GO:0015695
GeneOntologyBiologicalProcess	negative regulation of cartilage development	BMP4 ADAMTS7	1.25e-03	36	30	2	GO:0061037
GeneOntologyBiologicalProcess	peptide hormone secretion	CACNA1E FBN1 FFAR3 GPR42	1.33e-03	334	30	4	GO:0030072
GeneOntologyBiologicalProcess	negative regulation of leukocyte differentiation	BMP4 FBN1 LRRC17	1.35e-03	151	30	3	GO:1902106
GeneOntologyBiologicalProcess	norepinephrine transport	FFAR3 GPR42	1.39e-03	38	30	2	GO:0015874
GeneOntologyBiologicalProcess	negative regulation of protein transport	FBN1 FFAR3 GPR42	1.40e-03	153	30	3	GO:0051224
GeneOntologyBiologicalProcess	peptide secretion	CACNA1E FBN1 FFAR3 GPR42	1.46e-03	343	30	4	GO:0002790
GeneOntologyBiologicalProcess	type B pancreatic cell proliferation	WDR13 BTBD10	1.47e-03	39	30	2	GO:0044342
GeneOntologyBiologicalProcess	negative regulation of hemopoiesis	BMP4 FBN1 LRRC17	1.57e-03	159	30	3	GO:1903707
GeneOntologyBiologicalProcess	regulation of protein secretion	CACNA1E FBN1 FFAR3 GPR42	1.58e-03	350	30	4	GO:0050708
GeneOntologyBiologicalProcess	regulation of hormone secretion	CACNA1E FBN1 FFAR3 GPR42	1.66e-03	355	30	4	GO:0046883
GeneOntologyBiologicalProcess	peptide transport	CACNA1E FBN1 FFAR3 GPR42	1.66e-03	355	30	4	GO:0015833
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response	FFAR3 GPR42	1.70e-03	42	30	2	GO:0002675
GeneOntologyBiologicalProcess	cellular response to fatty acid	FFAR3 GPR42	1.70e-03	42	30	2	GO:0071398
GeneOntologyBiologicalProcess	positive regulation of SMAD protein signal transduction	BMP4 GDF7	1.78e-03	43	30	2	GO:0060391
GeneOntologyBiologicalProcess	negative regulation of establishment of protein localization	FBN1 FFAR3 GPR42	1.93e-03	171	30	3	GO:1904950
GeneOntologyBiologicalProcess	regulation of nervous system process	GRIN2D FFAR3 GPR42	2.06e-03	175	30	3	GO:0031644
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1A CACNA1E	2.21e-03	48	30	2	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1A CACNA1E	2.21e-03	48	30	2	GO:1902656
GeneOntologyBiologicalProcess	mucosal immune response	FFAR3 GPR42	2.21e-03	48	30	2	GO:0002385
GeneOntologyBiologicalProcess	signal release	CACNA1A CACNA1E FBN1 FFAR3 GPR42	2.31e-03	653	30	5	GO:0023061
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1A CACNA1E BMP4 GRIN2D	2.38e-03	392	30	4	GO:0070588
GeneOntologyBiologicalProcess	response to pain	CACNA1A CACNA1E	2.49e-03	51	30	2	GO:0048265
GeneOntologyBiologicalProcess	regulation of establishment of protein localization	CACNA1E BMP4 FBN1 FFAR3 GPR42	2.66e-03	674	30	5	GO:0070201
GeneOntologyBiologicalProcess	organ or tissue specific immune response	FFAR3 GPR42	2.79e-03	54	30	2	GO:0002251
GeneOntologyBiologicalProcess	regulation of hormone levels	CACNA1A CACNA1E FBN1 FFAR3 GPR42	2.83e-03	684	30	5	GO:0010817
GeneOntologyBiologicalProcess	BMP signaling pathway	BMP4 FBN1 GDF7	2.88e-03	197	30	3	GO:0030509
GeneOntologyBiologicalProcess	hormone secretion	CACNA1E FBN1 FFAR3 GPR42	3.05e-03	420	30	4	GO:0046879
GeneOntologyBiologicalProcess	amide transport	CACNA1E FBN1 FFAR3 GPR42	3.05e-03	420	30	4	GO:0042886
GeneOntologyBiologicalProcess	positive regulation of nervous system process	FFAR3 GPR42	3.11e-03	57	30	2	GO:0031646
MousePheno	abnormal sympathetic neuron innervation pattern	FFAR3 GPR42	9.97e-06	3	26	2	MP:0009284
MousePheno	abnormal sympathetic neuron physiology	FFAR3 GPR42	1.99e-05	4	26	2	MP:0009253
MousePheno	increased total lung capacity	FBN1 ADAMTS7	6.95e-05	7	26	2	MP:0010937
MousePheno	decreased circulating noradrenaline level	FFAR3 GPR42	6.95e-05	7	26	2	MP:0005664
MousePheno	abnormal total lung capacity	FBN1 ADAMTS7	1.48e-04	10	26	2	MP:0002304
MousePheno	abnormal sympathetic neuron morphology	FFAR3 GPR42	1.81e-04	11	26	2	MP:0001025
MousePheno	abnormal noradrenaline level	CACNA1A FFAR3 GPR42	2.01e-04	62	26	3	MP:0003964
Domain	GPR40-rel_orph	FFAR3 GPR42	1.39e-05	4	29	2	IPR013312
Domain	GPHH_dom	CACNA1A CACNA1E	4.87e-05	7	29	2	IPR031649
Domain	VDCC_a1su_IQ	CACNA1A CACNA1E	4.87e-05	7	29	2	IPR014873
Domain	Ca_chan_IQ	CACNA1A CACNA1E	4.87e-05	7	29	2	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1E	4.87e-05	7	29	2	PF08763
Domain	GPHH	CACNA1A CACNA1E	4.87e-05	7	29	2	PF16905
Domain	VDCCAlpha1	CACNA1A CACNA1E	1.04e-04	10	29	2	IPR002077
Domain	TGFb_propeptide	BMP4 GDF7	8.58e-04	28	29	2	PF00688
Domain	TGF-b_N	BMP4 GDF7	8.58e-04	28	29	2	IPR001111
Domain	TGF-beta-rel	BMP4 GDF7	1.12e-03	32	29	2	IPR015615
Domain	TGFb_CS	BMP4 GDF7	1.12e-03	32	29	2	IPR017948
Domain	TGFB	BMP4 GDF7	1.50e-03	37	29	2	SM00204
Domain	TGF_BETA_2	BMP4 GDF7	1.50e-03	37	29	2	PS51362
Domain	TGF_beta	BMP4 GDF7	1.50e-03	37	29	2	PF00019
Domain	TGF-b_C	BMP4 GDF7	1.50e-03	37	29	2	IPR001839
Domain	TGF_BETA_1	BMP4 GDF7	1.50e-03	37	29	2	PS00250
Domain	Channel_four-helix_dom	CACNA1A CACNA1E	3.52e-03	57	29	2	IPR027359
Domain	-	CACNA1A CACNA1E	3.52e-03	57	29	2	1.20.120.350
Domain	-	BMP4 GDF7	4.84e-03	67	29	2	2.10.90.10
Domain	Cystine-knot_cytokine	BMP4 GDF7	4.84e-03	67	29	2	IPR029034
Domain	Ion_trans_dom	CACNA1A CACNA1E	1.35e-02	114	29	2	IPR005821
Domain	Ion_trans	CACNA1A CACNA1E	1.35e-02	114	29	2	PF00520
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1A CACNA1E	1.39e-04	11	23	2	M47958
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1E	1.39e-04	11	23	2	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1E	1.39e-04	11	23	2	M26913
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST	BMP4 GDF7	2.64e-04	15	23	2	M47824
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY	BMP4 GDF7	4.75e-04	20	23	2	M47843
Pathway	WP_PROGERIAASSOCIATED_LIPODYSTROPHY	FBN1 FFAR3	5.77e-04	22	23	2	M42534
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1A CACNA1E	6.31e-04	23	23	2	M47666
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E MLX	6.93e-04	108	23	3	M17034
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1A CACNA1E	7.47e-04	25	23	2	M47948
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	BMP4 FBN1	1.23e-03	32	23	2	MM14854
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	BMP4 FBN1	1.64e-03	37	23	2	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	BMP4 FBN1	1.82e-03	39	23	2	MM14601
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	BMP4 FBN1	2.31e-03	44	23	2	M26969
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	CACNA1A CACNA1E	2.63e-03	47	23	2	M19708
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1A CACNA1E GRIN2D	2.91e-03	178	23	3	M2890
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	7.19e-07	2	30	2	20399779
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	7.19e-07	2	30	2	25637492
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	7.19e-07	2	30	2	19630535
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	7.19e-07	2	30	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	7.19e-07	2	30	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	7.19e-07	2	30	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	7.19e-07	2	30	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	7.19e-07	2	30	2	27550964
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	7.19e-07	2	30	2	23110765
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	7.19e-07	2	30	2	16381801
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	7.19e-07	2	30	2	35858247
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	7.19e-07	2	30	2	26522986
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	7.19e-07	2	30	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	7.19e-07	2	30	2	32073900
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	7.19e-07	2	30	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	7.19e-07	2	30	2	27664183
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	7.19e-07	2	30	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	7.19e-07	2	30	2	36362376
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	7.19e-07	2	30	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	7.19e-07	2	30	2	37019194
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	2.16e-06	3	30	2	22673524
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1E	2.16e-06	3	30	2	38996073
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	2.16e-06	3	30	2	12496283
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	2.16e-06	3	30	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	2.16e-06	3	30	2	25581519
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	2.16e-06	3	30	2	23665276
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1E	2.16e-06	3	30	2	24523520
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	2.16e-06	3	30	2	22190648
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	2.16e-06	3	30	2	34210970
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	2.16e-06	3	30	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	2.16e-06	3	30	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	2.16e-06	3	30	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	2.16e-06	3	30	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	2.16e-06	3	30	2	38524121
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	2.16e-06	3	30	2	31719611
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	2.16e-06	3	30	2	38329121
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	2.16e-06	3	30	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	2.16e-06	3	30	2	22493486
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1E	4.31e-06	4	30	2	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1E	4.31e-06	4	30	2	37141091
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	4.31e-06	4	30	2	21518883
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	4.31e-06	4	30	2	23401498
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	4.31e-06	4	30	2	15684720
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	4.31e-06	4	30	2	9344866
Pubmed	Lack of evidence that fibrillin1 regulates bone morphogenetic protein 4 activity in kidney or lung.	BMP4 FBN1	4.31e-06	4	30	2	36825302
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	4.31e-06	4	30	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	4.31e-06	4	30	2	29644622
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1E	7.18e-06	5	30	2	8825650
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	7.18e-06	5	30	2	24327954
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1E	7.18e-06	5	30	2	11296258
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	7.18e-06	5	30	2	19009545
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	7.18e-06	5	30	2	19047060
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1E	7.18e-06	5	30	2	15451373
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1E	1.08e-05	6	30	2	35324301
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1E	1.08e-05	6	30	2	9238069
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	1.08e-05	6	30	2	19460454
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1E	1.08e-05	6	30	2	12827191
Pubmed	Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.	BMP4 GDF7	1.51e-05	7	30	2	9786991
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1E	1.51e-05	7	30	2	35176221
Pubmed	Regulation of limb patterning by extracellular microfibrils.	BMP4 FBN1	1.51e-05	7	30	2	11470817
Pubmed	Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation.	BMP4 GDF7	2.01e-05	8	30	2	15975937
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	2.01e-05	8	30	2	34626852
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	BMP4 FBN1	2.01e-05	8	30	2	18339631
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1E	2.58e-05	9	30	2	16382099
Pubmed	Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.	BPTF BMP4	3.94e-05	11	30	2	18794365
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	LARP1 BPTF TSR1 CDK13 DDX18 BTBD10	4.02e-05	759	30	6	35915203
Pubmed	Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.	BMP4 GDF7	5.58e-05	13	30	2	11877374
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	XYLT2 LARP1 SCAF1 TSR1	6.26e-05	251	30	4	28077445
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1E	7.50e-05	15	30	2	20188150
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42	7.50e-05	15	30	2	32641826
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1E	7.50e-05	15	30	2	24453333
Pubmed	Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.	BMP4 GDF7	1.09e-04	18	30	2	19570847
Pubmed	Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.	BMP4 GDF7	1.50e-04	21	30	2	31038803
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	LARP1 FBN1 RBM26	1.63e-04	123	30	3	26912792
Pubmed	Central roles of the roof plate in telencephalic development and holoprosencephaly.	BMP4 GDF7	1.64e-04	22	30	2	16855091
Pubmed	FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.	BMP4 GDF7	1.80e-04	23	30	2	19668217
Pubmed	GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.	BMP4 FBN1	1.80e-04	23	30	2	29567669
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	LARP1 TSR1 DDX18 ZNF646	2.22e-04	349	30	4	25665578
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	LARP1 TSR1 CDK13 DDX18 CLASRP	2.50e-04	670	30	5	22990118
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	BMP4 FBN1	3.08e-04	30	30	2	32882513
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SCAF1 BMP4 GRIN2D ADAMTS7 CDK13 POLG	3.13e-04	1105	30	6	35748872
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	LARP1 TSR1 DDX18 CLASRP RBM26	3.33e-04	713	30	5	29802200
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	LARP1 DDX18 RBM26	3.67e-04	162	30	3	31363146
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	BMP4 FBN1	4.70e-04	37	30	2	34323105
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	LARP1 BPTF SCAF1 CDK13 CLASRP	4.84e-04	774	30	5	15302935
Pubmed	Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.	BPTF BMP4	4.96e-04	38	30	2	18974875
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1A CACNA1E	4.96e-04	38	30	2	30786075
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	XYLT2 LARP1 CDK13	5.49e-04	186	30	3	33637726
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	CACNA1A GRIN2D	6.96e-04	45	30	2	25979088
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	BPTF SCAF1 MLX CDK13 DDX18 CLASRP	7.23e-04	1294	30	6	30804502
Interaction	DHX8 interactions	SCAF1 CDK13 DDX18 CLASRP RBM26	5.51e-05	292	29	5	int:DHX8
Interaction	SRSF4 interactions	LARP1 BPTF SCAF1 CDK13 ZNF646	6.26e-05	300	29	5	int:SRSF4
Interaction	SRSF6 interactions	LARP1 BPTF SCAF1 CDK13 DDX18 CLASRP	6.84e-05	503	29	6	int:SRSF6
Cytoband	19q13.1	FFAR3 GPR42	6.00e-04	55	30	2	19q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SCAF1 GRIN2D FFAR3 GPR42 CLASRP	9.72e-04	1192	30	5	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	XYLT2 MLX SPPL2C	3.59e-03	473	30	3	chr17q21
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1E	3.35e-04	26	19	2	253
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R11 RBM26	1.52e-02	181	19	2	694
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_1000	MLF1 ZFTA PPP1R11 FBN1 MLX LRRC17 RBM26	8.84e-05	814	29	7	gudmap_developingGonad_e18.5_testes_1000
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_top-relative-expression-ranked_1000	MLF1 ZFTA PPP1R11 FBN1 MLX LRRC17 RBM26	9.18e-05	819	29	7	gudmap_developingGonad_e16.5_testes_1000
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	XYLT2 ZFTA FBN1 ADAMTS7	6.12e-06	179	30	4	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLF1 BMP4 FBN1 LRRC17	9.12e-06	198	30	4	a883e25cb7a78b2ecfb15cef4633bdd02dfafb12
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS7 FFAR3 LRRC17	1.46e-04	153	30	3	3b1b0cc8e9dd2b1484649789330713282ee44414
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-3\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADAMTS7 WDR13 FFAR3	1.55e-04	156	30	3	b464871ad7c8ce0d58013a27996639eac1e526d8
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FHOD3 FBN1	1.80e-04	164	30	3	a764b79a127c8f360af0b79a1da64658badf0dfa
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1A CACNA1E GPR42	2.14e-04	174	30	3	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A BMP4 ZFTA	2.17e-04	175	30	3	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.40e-04	181	30	3	cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.40e-04	181	30	3	269b39ac65790061d54eab47a8eeb024403f0348
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.40e-04	181	30	3	c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP4 ZFTA FBN1	2.44e-04	182	30	3	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LARP1 FHOD3 GRIN2D	2.44e-04	182	30	3	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP4 ZFTA FBN1	2.44e-04	182	30	3	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 ADAMTS7 LRRC17	2.48e-04	183	30	3	7e5c467fd1b156b928f1611a12ab4affb9f714b7
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 ADAMTS7 LRRC17	2.48e-04	183	30	3	63294d66e3ccf152ffe5d1237106764c14390b62
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZFTA FBN1 LRRC17	2.52e-04	184	30	3	4a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCell	390C-Fibroblasts-Fibroblast-F\|390C / Donor, Lineage, Cell class and subclass (all cells)	FBN1 GRIN2D LRRC17	2.56e-04	185	30	3	2c1f14f77faeee2acb388d997c5a27a7fef79be1
ToppCell	390C-Fibroblasts-Fibroblast-F-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FBN1 GRIN2D LRRC17	2.56e-04	185	30	3	37db8e0b1f59274227f6fc2362167eb44bd080ef
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZFTA FBN1 LRRC17	2.64e-04	187	30	3	fa8f221b4c2df61eadaa9c77e4cf45848b00330b
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 LDHD FHOD3	2.64e-04	187	30	3	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	facs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.64e-04	187	30	3	90a1078b0303799fba5d2ca4fa12076fd75b78b1
ToppCell	facs-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.64e-04	187	30	3	0f90bce2087aecfdbb377e6f46c6e468efbb6e28
ToppCell	facs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.64e-04	187	30	3	76c957b2976d38adb45e07bcf96c689442e1fc20
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 LDHD FHOD3	2.64e-04	187	30	3	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 LDHD FHOD3	2.64e-04	187	30	3	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	Endothelial-Endothelial-E\|Endothelial / shred on cell class and cell subclass (v4)	CACNA1A BMP4 FBN1	2.68e-04	188	30	3	2777eb7689b271c199021fe7d9db88ccebff14de
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 LDHD FHOD3	2.68e-04	188	30	3	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 LDHD FHOD3	2.68e-04	188	30	3	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	BMP4 FBN1 LRRC17	2.72e-04	189	30	3	c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.77e-04	190	30	3	17a73a658fb30a4322b31e38db7b240023738f29
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.77e-04	190	30	3	8cb950effc449ae59a915132ecc079be54d1acfe
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.77e-04	190	30	3	5dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	MLF1 CACNA1E FHOD3	2.81e-04	191	30	3	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.85e-04	192	30	3	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.85e-04	192	30	3	ac1477433704573f95111eee6263b93668d2845e
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.85e-04	192	30	3	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	droplet-Pancreas-Exocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 FBN1 LRRC17	2.94e-04	194	30	3	04ecb609d233a4b12e275c604810937830363e17
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 FBN1 LRRC17	2.94e-04	194	30	3	d47e3c7b22444aef0c7a37bc8cd8853b590a56dd
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BPTF GDF7 CDK13	2.94e-04	194	30	3	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	droplet-Pancreas-Exocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLF1 FBN1 LRRC17	2.94e-04	194	30	3	775600880bb77781de48085d8744c1030223de1f
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLF1 FBN1 LRRC17	3.08e-04	197	30	3	9af431323da6d099459b7360af40e5df998cffbd
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FBN1 ADAMTS7	3.12e-04	198	30	3	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLF1 FBN1 LRRC17	3.12e-04	198	30	3	d9ffc6589ed510ffa60c591f2a0fe123210f1455
ToppCell	15-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	BMP4 FBN1 LRRC17	3.12e-04	198	30	3	3d76393e72eed59b4dd16130ef5dd1d331ba5711
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FBN1 ADAMTS7 LRRC17	3.17e-04	199	30	3	60a653100aff31f7f96796ff2ec634798bfb4b0d
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	BMP4 FBN1 LRRC17	3.17e-04	199	30	3	c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FBN1 ADAMTS7	3.17e-04	199	30	3	e78f661b40da34768469549b6e755d330be6bbd8
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FBN1 LRRC17	3.17e-04	199	30	3	84545ced0c792bc77980a50d65e484eab648d47e
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLF1 FBN1 LRRC17	3.17e-04	199	30	3	c007cd51577e31553395ceaed70ad447e5854546
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FBN1 LRRC17	3.17e-04	199	30	3	36c1deac7ef0f9ebde6b2f7a63f7daa03d8c139a
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLF1 FBN1 LRRC17	3.17e-04	199	30	3	bfc157be6e9f84739848eb19b718de5b17f3fa88
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	LARP1 BPTF RBM26	3.17e-04	199	30	3	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	64d2941689d7ca8af54f9ba21c5aeabf719084ef
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	3dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCell	15-Airway-Mesenchymal\|Airway / Age, Tissue, Lineage and Cell class	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	13c4835b98e1bb91c2d04e08cdeaed8eba30b1d9
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	18-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	14ae55660f7412518dcb5cb982f6fe9f23553cfb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1A CACNA1E ZFTA	3.22e-04	200	30	3	5b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	76f3043cb88071256ff661885fe5a82a54f5b733
ToppCell	18-Airway-Mesenchymal\|Airway / Age, Tissue, Lineage and Cell class	BMP4 FBN1 LRRC17	3.22e-04	200	30	3	aca1e8def8ed6ae5749402d0288ad90656213de1
Drug	AC 110	CACNA1A CACNA1E	1.01e-05	4	30	2	CID000022860
Drug	3-7a	CACNA1A CACNA1E GRIN2D	1.43e-05	36	30	3	CID011987860
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1E	2.51e-05	6	30	2	CID000583065
Drug	alpha-sialylcholesterol	CACNA1A CACNA1E	2.51e-05	6	30	2	CID000133976
Drug	DB04724	CACNA1A LDHD LRRC17	3.43e-05	48	30	3	CID005288688
Drug	APMPA	CACNA1A CACNA1E	3.51e-05	7	30	2	CID000512300
Drug	NSC101791	XYLT2 CLASRP	4.68e-05	8	30	2	CID000003382
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1E	2.80e-06	3	29	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1E	5.59e-06	4	29	2	DOID:6364 (implicated_via_orthology)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1E	1.95e-05	7	29	2	DOID:0050951 (implicated_via_orthology)
Disease	Marfan syndrome (implicated_via_orthology)	BMP4 FBN1	4.18e-05	10	29	2	DOID:14323 (implicated_via_orthology)
Disease	descending aortic diameter	FBN1 GDF7 ADAMTS7	8.85e-05	88	29	3	EFO_0021788
Disease	right ventricular ejection fraction measurement	MLF1 FHOD3	3.99e-04	30	29	2	EFO_0021816
Disease	bowel opening frequency	FFAR3 GPR42	3.99e-04	30	29	2	EFO_0600084
Disease	right ventricular systolic volume measurement	MLF1 FHOD3	5.44e-04	35	29	2	EFO_0021815
Disease	epilepsy (implicated_via_orthology)	CACNA1A CACNA1E GRIN2D	5.44e-04	163	29	3	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHVHRQGGSRESRSG	CACNA1A	931	O00555
LHGASGGHERSRDRR	BTBD10	51	Q9BSF8
HKSDTHRSGGRERGR	CACNA1E	2071	Q15878
GHDGRGHALTRRRRA	BMP4	276	P12644
IGGLRSRHRGSSRGR	BPTF	36	Q12830
ERHREHRRRDGQRGG	CDK13	211	Q14004
RRRGGLGRAHIRAHT	ADAMTS7	111	Q9UKP4
GRGIHSRGRGAVHGR	RBM26	856	Q5T8P6
HAGEGRAGRARARRG	MLX	21	Q9UH92
RGRGRGRGGTRTHFD	LARP1	346	Q6PKG0
VRSRVNHGRAGGGRR	LRRC17	26	Q8N6Y2
HRVGRTARGLNGRGH	DDX18	511	Q9NVP1
LGRGGSHRRQRRVAG	GPR42	211	O15529
GHTHCVRGHRKGRRR	PPP1R11	86	O60927
ETRASRAKRRGGGGH	FBN1	36	P35555
DGRLLHTAGRGRHFR	LDHD	196	Q86WU2
GGEHRGLDRRRSRRH	FHOD3	351	Q2V2M9
LGRGGSHRRQRRVAG	FFAR3	211	O14843
EGGRRHRRARAGSSS	POLG	26	A0A3B3IS91
GAGRGHGRRGRSRCS	GDF7	336	Q7Z4P5
RRARRGGGSGGHHQL	SPPL2C	216	Q8IUH8
RALGARGHRRSVSRG	WDR13	101	Q9H1Z4
RSRGRRHSGGGSRDG	CLASRP	436	Q8N2M8
GDRYRRGGRGLRHHS	CLASRP	476	Q8N2M8
RGGRGLRHHSSSRSR	CLASRP	481	Q8N2M8
HKGGRHRGRGSAQRD	TSR1	16	Q2NL82
RRERHRGKHRDGGGS	SCAF1	626	Q9H7N4
DGRGRAHNRRGHNDG	MLF1	46	P58340
SRRHRKRAGGASGGR	ZNF646	671	O15015
HQRVHMERRGGGGTR	ZNF646	1276	O15015
RGSTGRRHGRWRGRA	XYLT2	71	Q9H1B5
RHIRRRHPGSTRLGG	ZFTA	456	C9JLR9
SHRRHRGGDLGTRRG	GRIN2D	1311	O15399