Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	host cell part	GBP6 GBP7	1.37e-04	6	64	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP6 GBP7	1.37e-04	6	64	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP6 GBP7	1.37e-04	6	64	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP6 GBP7	1.37e-04	6	64	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP6 GBP7	1.37e-04	6	64	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP6 GBP7	1.37e-04	6	64	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP6 GBP7	1.37e-04	6	64	2	GO:0030430
GeneOntologyCellularComponent	host cellular component	GBP6 GBP7	9.44e-04	15	64	2	GO:0018995
GeneOntologyCellularComponent	presynaptic endocytic zone	ITSN1 DNAJC6	1.37e-03	18	64	2	GO:0098833
GeneOntologyCellularComponent	actin cytoskeleton	XIRP1 CARMIL2 MYO9A ITSN1 SORBS1 SAMD14 MAP3K1	1.86e-03	576	64	7	GO:0015629
GeneOntologyCellularComponent	clathrin-coated pit	EPN3 ITSN1 CDHR5	1.90e-03	80	64	3	GO:0005905
Domain	XPG_N	ERCC5 ASTE1	1.15e-04	5	64	2	PF00752
Domain	XPG_DNA_repair_N	ERCC5 ASTE1	1.15e-04	5	64	2	IPR006085
Domain	Cyt_P450_E_grp-I	CYP1B1 CYP4A11 CYP20A1	4.91e-04	45	64	3	IPR002401
Domain	GBP_C	GBP6 GBP7	5.11e-04	10	64	2	PF02841
Domain	G_GB1_RHD3_dom	GBP6 GBP7	6.23e-04	11	64	2	IPR030386
Domain	Guanylate-bd_C	GBP6 GBP7	6.23e-04	11	64	2	IPR003191
Domain	GBP	GBP6 GBP7	6.23e-04	11	64	2	PF02263
Domain	Guanylate-bd_N	GBP6 GBP7	6.23e-04	11	64	2	IPR015894
Domain	G_GB1_RHD3	GBP6 GBP7	6.23e-04	11	64	2	PS51715
Domain	-	ERCC5 ASTE1	7.46e-04	12	64	2	3.40.50.1010
Domain	PIN_domain-like	ERCC5 ASTE1	1.02e-03	14	64	2	IPR029060
Domain	-	CYP1B1 CYP4A11 CYP20A1	1.04e-03	58	64	3	1.10.630.10
Domain	p450	CYP1B1 CYP4A11 CYP20A1	1.04e-03	58	64	3	PF00067
Domain	Cyt_P450	CYP1B1 CYP4A11 CYP20A1	1.14e-03	60	64	3	IPR001128
Domain	C2_dom	CADPS ITSN1 SEC63 DNAJC6	2.42e-03	164	64	4	IPR000008
Pubmed	An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease.	SEC63 NXN	3.55e-06	2	66	2	21251912
Pubmed	Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour.	FN1 FGFR1	3.55e-06	2	66	2	25319834
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CADPS BTBD7 GON4L SORBS1 SCRIB DNAJC6 ZNF365	1.23e-05	407	66	7	12693553
Pubmed	Functional proteomics mapping of a human signaling pathway.	EPN3 NCOR2 TRAF4 MAN1A2 FN1 ITSN1 HBP1 CAMSAP1	1.60e-05	591	66	8	15231748
Pubmed	Map3k1, Il6st, Gzmk, and Hspb3 gene coexpression network in the mechanism of freezing reaction in mice.	IL6ST MAP3K1	2.12e-05	4	66	2	21162133
Pubmed	The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.	CYP1B1 FN1 MAP3K1	2.30e-05	29	66	3	19094228
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	NCOR2 FN1 FGFR1 IL6ST	3.89e-05	99	66	4	19730683
Pubmed	Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.	FN1 TBX10 FGFR1	4.46e-05	36	66	3	20672350
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	ERCC5 FN1 SCRIB CAMSAP1	5.08e-05	106	66	4	31024071
Pubmed	Involvement of the T-box transcription factor Brachyury in early-stage embryonic mouse salivary gland.	FN1 BTBD7	5.29e-05	6	66	2	27369076
Pubmed	Biochemical dissection of Anosmin-1 interaction with FGFR1 and components of the extracellular matrix.	FN1 FGFR1	5.29e-05	6	66	2	20874775
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	ZC3H14 NCOR2 GGA2 ITSN1	5.87e-05	110	66	4	37219487
Pubmed	A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.	DCLRE1B TFR2	7.40e-05	7	66	2	18202258
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP1B1 CYP4A11 CYP20A1	8.18e-05	44	66	3	12745259
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP6 GBP7	9.86e-05	8	66	2	16689661
Pubmed	FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.	FN1 FGFR1	9.86e-05	8	66	2	11703922
Pubmed	Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology.	CYP1B1 FGFR1	9.86e-05	8	66	2	18415014
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	EPN3 CARMIL2 CDHR5 SCRIB CAMSAP1 SLC12A7 IL6ST	1.02e-04	569	66	7	30639242
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ZC3H14 METTL24 MYO9A TET1 CYP20A1 ASTE1 BPIFA3 NXN ZNF365 MAP3K1	1.11e-04	1242	66	10	30973865
Pubmed	Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage.	FN1 SCRIB	1.27e-04	9	66	2	36989113
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	OPN4 ASAH2 TET1 SORBS1 CPN1 ZNF365	1.38e-04	415	66	6	16385451
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	HIVEP2 MAN1A2 FN1 CADPS ITSN1 SORBS1 TAF1 SCRIB KDM6B ZNF365	1.47e-04	1285	66	10	35914814
Pubmed	Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.	TBX10 FGFR1	1.58e-04	10	66	2	20544801
Pubmed	Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.	ITSN1 FGFR1	1.58e-04	10	66	2	16798735
Pubmed	SOX17 links gut endoderm morphogenesis and germ layer segregation.	FN1 FGFR1	1.58e-04	10	66	2	25419850
Pubmed	Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.	FGFR1 SCRIB	1.93e-04	11	66	2	17556662
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP6 GBP7	1.93e-04	11	66	2	18025219
Pubmed	A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.	NCOR2 FN1 SORBS1	2.07e-04	60	66	3	19075228
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPN3 NCOR2 TRAF4 HIVEP2 BTBD7 AKNA FGFR1 KDM6B CAMSAP1	2.33e-04	1105	66	9	35748872
Pubmed	TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.	MGAM TRAF4	2.73e-04	13	66	2	16052631
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	CYP1B1 CYP4A11 CYP20A1	2.74e-04	66	66	3	19898482
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	CYP1B1 FGFR1 BMP15	3.13e-04	69	66	3	30352686
Pubmed	CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain.	FGFR1 IL6ST	3.18e-04	14	66	2	15634701
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP1B1 CYP4A11 CYP20A1	3.26e-04	70	66	3	15128046
Pubmed	Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.	ITSN1 SORBS1	3.67e-04	15	66	2	9630982
Pubmed	Large-scale genotyping identifies 41 new loci associated with breast cancer risk.	DCLRE1B ZNF365 MAP3K1	4.16e-04	76	66	3	23535729
Pubmed	TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field.	FN1 SCRIB	4.18e-04	16	66	2	25371366
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	NCOR2 TET1 SORBS1 FGFR1 DNAJC6 NXN	5.41e-04	536	66	6	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	NCOR2 TET1 SORBS1 FGFR1 DNAJC6 NXN	5.52e-04	538	66	6	10512203
Pubmed	α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice.	FN1 FGFR1	5.94e-04	19	66	2	21799763
Pubmed	A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.	GBP6 GBP7	5.94e-04	19	66	2	21551061
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP1B1 CYP20A1	6.59e-04	20	66	2	9890157
Pubmed	Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.	NCOR2 KDM6B	7.28e-04	21	66	2	30254164
Pubmed	Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development.	FN1 SCRIB	7.28e-04	21	66	2	25521757
Pubmed	An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.	GBP6 GBP7	7.28e-04	21	66	2	19158679
Pubmed	The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.	TRAF4 MAGEL2	7.28e-04	21	66	2	25590999
Pubmed	Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.	FN1 FGFR1	7.99e-04	22	66	2	24000064
Pubmed	Genome-wide association study identifies five new breast cancer susceptibility loci.	ZNF365 MAP3K1	7.99e-04	22	66	2	20453838
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	TRAF4 ITSN1 HBP1 SORBS1	9.13e-04	226	66	4	31452512
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ERCC5 AOC1 FN1 GBP7 ITSN1 RNF181 TET1 SEC63	1.01e-03	1084	66	8	11544199
Pubmed	Gse1, a component of the CoREST complex, is required for placenta development in the mouse.	FN1 SCRIB	1.03e-03	25	66	2	37019373
Pubmed	Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.	FN1 SCRIB	1.12e-03	26	66	2	37060937
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	NCOR2 TET1	1.21e-03	27	66	2	23395962
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIVEP2 CARMIL2 MYO9A TET1 SORBS1 SCRIB CAMSAP1	1.22e-03	861	66	7	36931259
Pubmed	Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature.	FN1 FGFR1	1.30e-03	28	66	2	31719045
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOR2 MAGEL2 ITSN1 CAMSAP1 MAP3K1	1.36e-03	430	66	5	35044719
Pubmed	Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.	FN1 FGFR1	1.39e-03	29	66	2	14522949
Pubmed	SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.	NCOR2 KDM6B	1.39e-03	29	66	2	17928865
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	FN1 CDHR5 FGFR1 IL6ST	1.47e-03	257	66	4	16335952
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	ITSN1 TAF1	1.59e-03	31	66	2	25838543
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CYP1B1 NCOR2 EOGT MAN1A2 FN1 ARSK RNF181 CYP20A1 SEC63	1.62e-03	1451	66	9	30550785
Pubmed	Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.	FN1 TET1	1.80e-03	33	66	2	36522157
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	CYP1B1 FGFR1 SLC12A7 BMP15	1.88e-03	275	66	4	20734064
Cytoband	1p22.2	GBP6 GBP7	7.51e-04	28	66	2	1p22.2
Cytoband	17q21.33	EPN3 SAMD14	1.61e-03	41	66	2	17q21.33
Cytoband	5q11.2	IL6ST MAP3K1	2.58e-03	52	66	2	5q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr10q24	PDZD7 SORBS1 CPN1	2.60e-03	189	66	3	chr10q24
Coexpression	ZHENG_FOXP3_TARGETS_IN_THYMUS_UP	GBP6 HIVEP2 MAN1A2 MYO9A HBP1 SEC63 MAP3K1	6.28e-07	199	65	7	M1746
Coexpression	ZHENG_FOXP3_TARGETS_IN_THYMUS_UP	GBP6 HIVEP2 MAN1A2 MYO9A HBP1 SEC63 MAP3K1	6.49e-07	200	65	7	MM1033
Coexpression	GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_30H_UP	GBP7 SORBS1 FGFR1 SLC12A7 NXN IL6ST	1.04e-05	200	65	6	M9649
Coexpression	ZHU_CMV_ALL_DN	CYP1B1 ERCC5 HIVEP2 ITSN1 IL6ST	1.18e-05	119	65	5	M14555
Coexpression	GSE6674_UNSTIM_VS_ANTI_IGM_STIM_BCELL_UP	AOC1 ITSN1 CYP20A1 SEC63 IL6ST	5.35e-05	163	65	5	M6915
CoexpressionAtlas	alpha beta T cells, T.4int8+.Th, 4int 8+ TCRhi, Thymus, avg-3	TRAF4 GBP6 CARMIL2 TET1 KDM6B SLC12A7 IL6ST	2.57e-05	289	64	7	GSM399367_500
CoexpressionAtlas	alpha beta T cells, T.4+8int.Th, 4+ 8int TCRhi, Thymus, avg-3	TRAF4 GBP6 HIVEP2 CARMIL2 TET1 KDM6B IL6ST	3.41e-05	302	64	7	GSM399362_500
CoexpressionAtlas	alpha beta T cells, T.DP69+.Th, 4+ 8+ TCRlo/int 69+, Thymus, avg-3	TRAF4 HIVEP2 CARMIL2 TET1 KDM6B DNAJC6 IL6ST	3.63e-05	305	64	7	GSM399394_500
CoexpressionAtlas	kidney_adult_Mesangium_Meis_k-means-cluster#4_top-relative-expression-ranked_100	GBP6 GBP7	8.89e-05	5	64	2	gudmap_kidney_adult_Mesangium_Meis_k4_100
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 CYP1B1 FN1 NXN IL6ST	9.01e-06	189	66	5	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	NCOR2 HIVEP2 FGFR1 KDM6B NXN	9.01e-06	189	66	5	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	RA\|World / Chamber and Cluster_Paper	HIVEP2 FN1 CADPS PXDNL FGFR1	1.02e-05	194	66	5	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	healthy_donor-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)\|healthy_donor / Disease condition, Lineage, Cell class and subclass	GBP7 PDZD7 SORBS1 ZNF365	5.27e-05	138	66	4	97f5dc17522462133e582b508ad0ef036e656872
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CYP1B1 GBP6 GBP7 NXN	8.48e-05	156	66	4	6c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HIVEP2 AOC1 IL6ST MAP3K1	1.10e-04	167	66	4	ced6ed9b412739c6ced622523347c10295edbf53
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 NCOR2 GRIN3B DNAJC6	1.29e-04	174	66	4	46bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	GBP7 CYP4A11 CPN1 TFR2	1.29e-04	174	66	4	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 FN1 GBP7 KDM6B	1.47e-04	180	66	4	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CYP1B1 CYP4A11 FGFR1 GALNT5	1.54e-04	182	66	4	0e52ba34e179d9bfaac7b49920b44c710b2b8dad
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-5\|TCGA-Breast / Sample_Type by Project: Shred V9	EPN3 FN1 TBX10 WSB2	1.54e-04	182	66	4	9e48d5b634603bc7a8d29290202a311457678328
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 EOGT SLC12A7 NXN	1.57e-04	183	66	4	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SORBS1 GALNT5 DNAJC6 TFR2	1.57e-04	183	66	4	b52d7683dc6652766e814ebe935c264ecd610c4b
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 SLC12A7 NXN IL6ST	1.57e-04	183	66	4	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-erythrocytic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SORBS1 GALNT5 DNAJC6 TFR2	1.57e-04	183	66	4	1d77d8d8c8f78f43dd8864e76f294ee66d4942c2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NCOR2 GRIN3B DNAJC6 MAP3K1	1.57e-04	183	66	4	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZMYND15 EOGT SLC12A7 NXN	1.60e-04	184	66	4	8ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	XIRP1 CADPS PXDNL SORBS1	1.63e-04	185	66	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EOGT SORBS1 FGFR1 NXN	1.63e-04	185	66	4	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGA2 CARMIL2 AKNA MAP3K1	1.67e-04	186	66	4	6e3bea4319d2a1bb060fe0cb1bb8bafafa05f83c
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac\|normal_Pleural_Fluid / Location, Cell class and cell subclass	ZMYND15 CYP1B1 FN1 ITSN1	1.67e-04	186	66	4	3314def702fe6a5056d0dadbb3a587c5d1a16412
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITSN1 DCLRE1B DNAJC6 TFR2	1.67e-04	186	66	4	e5014443e9d6e25943308483e20d48b776ae5373
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITSN1 DCLRE1B DNAJC6 TFR2	1.67e-04	186	66	4	affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCell	LPS_only-Hematopoietic_Meg-Ery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITSN1 DCLRE1B DNAJC6 TFR2	1.67e-04	186	66	4	40d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASAH2 SLC12A7 SAMD14 CCDC180	1.70e-04	187	66	4	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASAH2 SLC12A7 SAMD14 CCDC180	1.70e-04	187	66	4	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HIVEP2 KDM6B IL6ST MAP3K1	1.74e-04	188	66	4	939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	HIVEP2 FGFR1 KDM6B NXN	1.77e-04	189	66	4	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 FN1 NXN IL6ST	1.77e-04	189	66	4	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 SLC12A7 NXN IL6ST	1.81e-04	190	66	4	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP1B1 FGFR1 SLC12A7 NXN	1.81e-04	190	66	4	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP1B1 XIRP1 FGFR1 KDM6B	1.85e-04	191	66	4	f5ce33af56178333730be308253943c54a0724cf
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR2 SORBS1 KDM6B NXN	1.85e-04	191	66	4	2f733d510a4862565a817f59829d8387d7ea26d9
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR2 SORBS1 KDM6B NXN	1.85e-04	191	66	4	8691eba35793e4e90f93d50c2145847ee51289f7
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 SLC12A7 NXN IL6ST	1.88e-04	192	66	4	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 XIRP1 FN1 GALNT5	1.88e-04	192	66	4	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 XIRP1 FN1 GALNT5	1.88e-04	192	66	4	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 XIRP1 FN1 GALNT5	2.00e-04	195	66	4	47762d9e442fb1f6f0033e3e10f4c6e498d2c081
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 FN1 ITSN1 SORBS1	2.04e-04	196	66	4	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 SLC12A7 NXN IL6ST	2.04e-04	196	66	4	e386526332138e636aef2542c11316347a45689c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CYP1B1 FN1 ITSN1 SORBS1	2.04e-04	196	66	4	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	T_cells-Treg_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	HIVEP2 FGFR1 IL6ST MAP3K1	2.08e-04	197	66	4	ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SORBS1 FGFR1 IL6ST	2.08e-04	197	66	4	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	T_cells-Treg_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	HIVEP2 FGFR1 IL6ST MAP3K1	2.08e-04	197	66	4	de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega\|Control_saline / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.12e-04	198	66	4	1a39a98beef68e1e6d3adc25270a3336fcc5baf4
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|Control_saline / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.12e-04	198	66	4	dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary\|Control_saline / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.12e-04	198	66	4	cfc2a860bae883299987d3e374d0476ca20e1bdd
ToppCell	Enterocyte-C_01\|Enterocyte / shred on cell type and cluster	MGAM AOC1 TBX10 CDHR5	2.12e-04	198	66	4	4e2c30d6fd1d59db98a52bfcc3206b4c4ac5abe2
ToppCell	T_cells-CCR7+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ERCC5 HBP1 KDM6B IL6ST	2.16e-04	199	66	4	467820d6abe3024d9d655b9672c2f9cdc1303db3
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.16e-04	199	66	4	f894c88ecc7fd0edca28587801fa59352d10f750
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CYP1B1 FN1 PXDNL IL6ST	2.16e-04	199	66	4	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CYP1B1 PXDNL ITSN1 IL6ST	2.16e-04	199	66	4	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.16e-04	199	66	4	2b754670fe77c2301afcdcfc73a1e52cc0cd1de3
ToppCell	Influenza-Influenza_Severe-Others\|Influenza_Severe / Disease, condition lineage and cell class	SORBS1 SAMD14 DNAJC6 TFR2	2.20e-04	200	66	4	8909da4f7da3bc469a2becb4cfa5c25012af5845
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CYP1B1 PXDNL ITSN1 IL6ST	2.20e-04	200	66	4	b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.20e-04	200	66	4	f100edfd2b3b742458cbbf34de9c403c4d272d3c
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CYP1B1 PXDNL ITSN1 IL6ST	2.20e-04	200	66	4	50ca6550998e461ef26dd670351060bd940765a8
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	CYP1B1 PXDNL ITSN1 IL6ST	2.20e-04	200	66	4	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.20e-04	200	66	4	f99e214eb680fd82a33f2b1524fbfca265d1cc42
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ITSN1 DCLRE1B DNAJC6 TFR2	2.20e-04	200	66	4	d85074b362b11e5a523a5325d203a61aa2759a7a
Computational	Heparin binding.	AOC1 FN1 FGFR1	1.16e-04	28	37	3	MODULE_385
Drug	Benoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A	TRAF4 GGA2 MAN1A2 BTBD7 ITSN1 TAF1 MAP3K1	1.05e-06	190	64	7	4115_DN
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Down 200; 10.4uM; PC3; HT_HG-U133A	GGA2 HIVEP2 BTBD7 ITSN1 GON4L FGFR1 CAMSAP1	1.43e-06	199	64	7	7295_DN
Drug	thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	CYP1B1 HIVEP2 CYP20A1 HBP1 KDM6B IL6ST	4.89e-06	155	64	6	1068_UP
Drug	4-hydroxy-2-nonenal	CYP1B1 ERCC5 HIVEP2 CADPS ITSN1 AKNA WSB2 HBP1 FGFR1 KDM6B IL6ST	1.25e-05	798	64	11	ctd:C027576
Drug	Eburnamonine (-) [4880-88-0]; Down 200; 13.6uM; PC3; HT_HG-U133A	CYP1B1 HIVEP2 BTBD7 FGFR1 TAF1 ZNF365	1.57e-05	190	64	6	7154_DN
Drug	Carbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	BTBD7 CYP20A1 FGFR1 TAF1 IL6ST MAP3K1	1.66e-05	192	64	6	4110_DN
Drug	Fluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A	MAN1A2 FN1 FGFR1 CAMSAP1 IL6ST BMP15	1.71e-05	193	64	6	4129_DN
Drug	5248896; Up 200; 11uM; MCF7; HT_HG-U133A_EA	CYP1B1 BTBD7 GON4L FGFR1 ZNF365 MAP3K1	1.76e-05	194	64	6	955_UP
Drug	Oxantel pamoate [68813-55-8]; Up 200; 6.6uM; PC3; HT_HG-U133A	CYP1B1 MGAM GGA2 MAN1A2 FGFR1 MAP3K1	1.76e-05	194	64	6	6738_UP
Drug	Nifedipine [21829-25-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	CYP1B1 TRAF4 GGA2 HIVEP2 ASTE1 FGFR1	1.76e-05	194	64	6	1814_DN
Drug	trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HG-U133A	FN1 GON4L HBP1 FGFR1 KDM6B IL6ST	1.81e-05	195	64	6	421_UP
Drug	Boldine [476-70-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	GGA2 FN1 TBX10 FGFR1 CAMSAP1 IL6ST	1.87e-05	196	64	6	4122_DN
Drug	monastrol; Down 200; 100uM; MCF7; HG-U133A	CYP1B1 GGA2 FN1 ASTE1 PDZD7 FGFR1	1.87e-05	196	64	6	610_DN
Drug	Triprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; PC3; HT_HG-U133A	CYP1B1 GGA2 HIVEP2 BTBD7 FGFR1 KDM6B	1.92e-05	197	64	6	7248_DN
Drug	Dicloxacillin sodium salt [13412-64-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A	MAN1A2 ITSN1 SORBS1 FGFR1 IL6ST MAP3K1	1.92e-05	197	64	6	3307_UP
Drug	Mimosine [500-44-7]; Up 200; 20.2uM; MCF7; HT_HG-U133A	TRAF4 FN1 BTBD7 ITSN1 GON4L KDM6B	1.92e-05	197	64	6	5302_UP
Drug	Ioxaglic acid [59017-64-0]; Up 200; 3.2uM; HL60; HT_HG-U133A	BTBD7 CAMSAP1 SAMD14 IL6ST BMP15 TFR2	2.03e-05	199	64	6	2966_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	GGA2 FN1 FGFR1 TAF1 KDM6B BMP15	2.03e-05	199	64	6	5695_DN
Drug	Etanidazole [22668-01-5]; Down 200; 18.6uM; HL60; HT_HG-U133A	MYO9A ITSN1 PDZD7 TAF1 SCRIB TFR2	2.09e-05	200	64	6	2510_DN
Drug	thioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A	MAN1A2 FN1 ITSN1 FGFR1 TAF1 TFR2	2.09e-05	200	64	6	5921_DN
Drug	nitrazine paper	AOC1 FN1	2.33e-05	3	64	2	CID005473499
Drug	MObetaDG	OPN4 FN1	1.16e-04	6	64	2	CID000124815
Drug	tranilast	CYP1B1 NCOR2	1.16e-04	6	64	2	ctd:C012293
Drug	Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; MCF7; HT_HG-U133A	CYP1B1 HIVEP2 KDM6B SLC12A7 DNAJC6	1.20e-04	171	64	5	5247_UP
Drug	Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; MCF7; HT_HG-U133A	CYP1B1 HIVEP2 KDM6B SLC12A7 DNAJC6	1.27e-04	173	64	5	5612_UP
Drug	Emetine dihydrochloride [316-42-7]; Up 200; 7.2uM; MCF7; HT_HG-U133A	CYP1B1 HIVEP2 KDM6B SLC12A7 DNAJC6	1.37e-04	176	64	5	4827_UP
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	CYP1B1 GGA2 EOGT ITSN1 ASTE1	1.78e-04	186	64	5	6953_DN
Drug	Apigenin [520-36-5]; Down 200; 14.8uM; PC3; HT_HG-U133A	CYP1B1 GGA2 EOGT ITSN1 ZNF365	1.78e-04	186	64	5	4578_DN
Drug	AC1L1KIN	CYP1B1 NCOR2 CYP4A11 CYP20A1	1.82e-04	100	64	4	CID000005516
Drug	LY 294002; Down 200; 10uM; HL60; HT_HG-U133A	GGA2 EOGT FN1 GON4L CAMSAP1	1.92e-04	189	64	5	1168_DN
Drug	Luteolin [491-70-3]; Down 200; 14uM; MCF7; HT_HG-U133A	EOGT BTBD7 ITSN1 TAF1 DNAJC6	1.96e-04	190	64	5	3379_DN
Drug	5707885; Down 200; 50uM; PC3; HT_HG-U133A	CYP1B1 BTBD7 TBX10 FGFR1 IL6ST	2.01e-04	191	64	5	6390_DN
Drug	Denatonium benzoate [3734-33-6]; Down 200; 9uM; HL60; HT_HG-U133A	CYP1B1 HIVEP2 GON4L CAMSAP1 MAP3K1	2.01e-04	191	64	5	3123_DN
Drug	LY 294002; Up 200; 10uM; PC3; HT_HG-U133A	CYP1B1 HIVEP2 HBP1 IL6ST TFR2	2.01e-04	191	64	5	4451_UP
Drug	Luteolin [491-70-3]; Down 200; 14uM; PC3; HT_HG-U133A	CYP1B1 GGA2 EOGT ITSN1 KDM6B	2.01e-04	191	64	5	6658_DN
Drug	2-propylpentanoic acid; Up 200; 1000uM; PC3; HT_HG-U133A	TRAF4 BTBD7 ITSN1 DNAJC6 ZNF365	2.06e-04	192	64	5	1209_UP
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; HL60; HT_HG-U133A	BTBD7 PDZD7 FGFR1 KDM6B TFR2	2.06e-04	192	64	5	2335_DN
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; PC3; HT_HG-U133A	CYP1B1 GGA2 FGFR1 TAF1 TFR2	2.11e-04	193	64	5	5922_DN
Drug	PHA-00851261E [724719-49-7]; Up 200; 1uM; MCF7; HT_HG-U133A	CYP1B1 NCOR2 TRAF4 GGA2 CAMSAP1	2.11e-04	193	64	5	3857_UP
Drug	PHA-00851261E [724719-49-7]; Up 200; 10uM; MCF7; HT_HG-U133A	CYP1B1 NCOR2 TRAF4 MAN1A2 IL6ST	2.16e-04	194	64	5	3854_UP
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; HL60; HT_HG-U133A	CYP1B1 TRAF4 FN1 PDZD7 MAP3K1	2.16e-04	194	64	5	6178_DN
Drug	Etifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	NCOR2 FGFR1 TAF1 CAMSAP1 IL6ST	2.16e-04	194	64	5	2838_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	MAN1A2 FN1 HBP1 IL6ST BMP15	2.22e-04	195	64	5	3393_DN
Drug	radicicol; Down 200; 0.1uM; MCF7; HG-U133A	CYP1B1 MAN1A2 FN1 FGFR1 KDM6B	2.22e-04	195	64	5	489_DN
Drug	Sulfapyridine [144-83-2]; Down 200; 16uM; MCF7; HT_HG-U133A	GGA2 FGFR1 TAF1 IL6ST MAP3K1	2.22e-04	195	64	5	6799_DN
Drug	Phentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A	NCOR2 TRAF4 FGFR1 CAMSAP1 IL6ST	2.22e-04	195	64	5	3860_UP
Drug	Mexiletine hydrochloride [5370-01-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	TRAF4 GGA2 FN1 CAMSAP1 IL6ST	2.22e-04	195	64	5	3862_UP
Drug	Chlormezanone [80-77-3]; Down 200; 14.6uM; HL60; HG-U133A	GGA2 FN1 MYO9A CAMSAP1 SLC12A7	2.27e-04	196	64	5	1620_DN
Drug	Clemizole hydrochloride [1163-36-6]; Down 200; 11uM; HL60; HT_HG-U133A	TRAF4 EOGT BTBD7 FGFR1 BMP15	2.27e-04	196	64	5	2339_DN
Drug	ikarugamycin; Up 200; 2uM; MCF7; HT_HG-U133A_EA	CYP1B1 GGA2 FGFR1 CAMSAP1 MAP3K1	2.27e-04	196	64	5	918_UP
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; HL60; HT_HG-U133A	TRAF4 FN1 BTBD7 FGFR1 KDM6B	2.27e-04	196	64	5	2361_DN
Drug	Beclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; PC3; HT_HG-U133A	CYP1B1 GON4L FGFR1 TAF1 IL6ST	2.27e-04	196	64	5	4580_DN
Drug	Miconazole [22916-47-8]; Up 200; 9.6uM; PC3; HT_HG-U133A	FN1 TBX10 KDM6B SAMD14 MAP3K1	2.27e-04	196	64	5	6615_UP
Drug	Thiamine hydrochloride [67-03-8]; Up 200; 11.8uM; HL60; HG-U133A	GGA2 FN1 GON4L CAMSAP1 TFR2	2.27e-04	196	64	5	1744_UP
Drug	PF-01378883-00 [351320-41-7]; Up 200; 10uM; MCF7; HT_HG-U133A	AOC1 TBX10 SORBS1 SAMD14 TFR2	2.27e-04	196	64	5	6363_UP
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; PC3; HT_HG-U133A	TRAF4 GGA2 BTBD7 FGFR1 IL6ST	2.32e-04	197	64	5	4556_DN
Drug	Fluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	TRAF4 GGA2 HIVEP2 FN1 ZNF365	2.32e-04	197	64	5	5356_DN
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A	NCOR2 HIVEP2 GON4L CAMSAP1 MAP3K1	2.32e-04	197	64	5	6947_UP
Drug	Cinoxacin [28657-80-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A	BTBD7 FGFR1 TAF1 MAP3K1 BMP15	2.32e-04	197	64	5	3463_UP
Drug	Benzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	GGA2 FN1 ITSN1 FGFR1 IL6ST	2.32e-04	197	64	5	4501_DN
Drug	thioridazine hydrochloride; Up 200; 1uM; MCF7; HG-U133A	GGA2 PDZD7 FGFR1 KDM6B IL6ST	2.32e-04	197	64	5	422_UP
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	GGA2 EOGT HIVEP2 PDZD7 CAMSAP1	2.32e-04	197	64	5	1314_DN
Drug	Deoxycorticosterone [64-85-7]; Down 200; 12.2uM; PC3; HT_HG-U133A	CYP1B1 NCOR2 GGA2 FGFR1 TAF1	2.32e-04	197	64	5	6758_DN
Drug	Vitexin [3681-93-4]; Up 200; 9.2uM; HL60; HT_HG-U133A	TRAF4 MYO9A ITSN1 CYP20A1 CAMSAP1	2.38e-04	198	64	5	2155_UP
Drug	Metformin hydrochloride [1115-70-4]; Down 200; 24.2uM; MCF7; HT_HG-U133A	HIVEP2 GON4L FGFR1 NXN IL6ST	2.38e-04	198	64	5	1694_DN
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A	BTBD7 SORBS1 FGFR1 IL6ST BMP15	2.38e-04	198	64	5	6557_DN
Drug	Riluzole hydrochloride; Down 200; 14.8uM; PC3; HT_HG-U133A	CYP1B1 NCOR2 GGA2 CYP20A1 GON4L	2.38e-04	198	64	5	3666_DN
Drug	cox-2 inhibitor I; Down 200; 10uM; MCF7; HG-U133A	CYP1B1 GGA2 FN1 ASTE1 PDZD7	2.38e-04	198	64	5	612_DN
Drug	Mebendazole [31431-39-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A	CYP1B1 GGA2 FGFR1 DNAJC6 NXN	2.38e-04	198	64	5	4694_DN
Drug	Equilin [474-86-2]; Down 200; 15uM; PC3; HT_HG-U133A	CYP1B1 NCOR2 SORBS1 FGFR1 SLC12A7	2.38e-04	198	64	5	4659_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; HL60; HG-U133A	TRAF4 GGA2 PDZD7 CAMSAP1 BMP15	2.38e-04	198	64	5	2032_UP
Drug	Salsolinol hydrobromide [38221-21-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A	HIVEP2 BTBD7 SORBS1 KDM6B CAMSAP1	2.38e-04	198	64	5	2791_UP
Drug	Karakoline [39089-30-0]; Up 200; 10.6uM; HL60; HT_HG-U133A	TRAF4 HIVEP2 DNAJC6 MAP3K1 BMP15	2.43e-04	199	64	5	2203_UP
Drug	Allantoin [97-59-6]; Up 200; 25.2uM; MCF7; HT_HG-U133A	GGA2 BTBD7 GON4L FGFR1 CAMSAP1	2.43e-04	199	64	5	5471_UP
Drug	Dizocilpine maleate [77086-22-7]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CYP1B1 AOC1 ITSN1 SORBS1 TAF1	2.43e-04	199	64	5	2232_UP
Drug	cox-2 inhibitor I; Down 200; 10uM; MCF7; HG-U133A	ZC3H14 PDZD7 FGFR1 CPN1 TFR2	2.43e-04	199	64	5	207_DN
Drug	Sulfabenzamide [127-71-9]; Down 200; 14.4uM; PC3; HT_HG-U133A	NCOR2 GGA2 FN1 GON4L DNAJC6	2.43e-04	199	64	5	6634_DN
Drug	Cefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; HL60; HT_HG-U133A	TRAF4 BTBD7 KDM6B MAP3K1 BMP15	2.43e-04	199	64	5	2564_DN
Drug	Epirizole [18694-40-1]; Down 200; 17uM; MCF7; HT_HG-U133A	ZC3H14 GON4L FGFR1 KDM6B DNAJC6	2.49e-04	200	64	5	1681_DN
Drug	Pindolol [13523-86-9]; Down 200; 16.2uM; PC3; HT_HG-U133A	CYP1B1 GGA2 BTBD7 ASTE1 DCLRE1B	2.49e-04	200	64	5	2075_DN
Drug	dialdehyde starch	FN1 TET1	2.76e-04	9	64	2	CID000024776
Disease	intellectual disability (implicated_via_orthology)	ZC3H14 HIVEP2 ITSN1	5.61e-04	75	63	3	DOID:1059 (implicated_via_orthology)
Disease	Arthrogryposis	MAGEL2 MYO9A	9.18e-04	21	63	2	C0003886
Disease	osteoarthritis (is_implicated_in)	NCOR2 FGFR1	1.64e-03	28	63	2	DOID:8398 (is_implicated_in)
Disease	Malignant neoplasm of breast	CYP1B1 XIRP1 FN1 SORBS1 FGFR1 GALNT5 ZNF365 MAP3K1	1.97e-03	1074	63	8	C0006142
Disease	obsessive-compulsive symptom measurement	MGAM CADPS	2.00e-03	31	63	2	EFO_0007802

Protein segments in the cluster

Peptide	Gene	Start	Entry
NEHKVKNLHPPWILS	ARSK	391	Q6UWY0
LQAADHVLQHPKWPF	EOGT	506	Q5NDL2
DSPPQKWPELSHGLH	CARMIL2	941	Q6F5E8
TDPWALNSPHHKLPS	EPN3	386	Q9H201
YGLHHNPKVWPNPEV	CYP4A11	416	Q02928
NDPWHPPVVFEQFLH	AOC1	641	P19801
LLQLPNTKWPTHHCD	CCDC180	1261	Q9P1Z9
QAFLPDHKANWAPVP	CDHR5	716	Q9HBB8
DHKANWAPVPSPTHD	CDHR5	721	Q9HBB8
WPADLEKQPSHHPLR	DCLRE1B	381	Q9H816
TIHNHLWQPKRPAVP	CAMSAP1	1581	Q5T5Y3
HLDKTSWNALPPQPL	ASTE1	386	Q2TB18
ILHPTPNSPKQSEWH	CADPS	481	Q9ULU8
PHHAWDEEPKPLLCS	NCOR2	2491	Q9Y618
KAPTHIWQPLPAQEA	MAGEL2	621	Q9UJ55
HKQWHSQHDPQLPPA	NMUR2	346	Q9GZQ4
LHTGELSKPHPWHPD	ASAH2	506	Q9NR71
LSKPHPWHPDIVDVQ	ASAH2	511	Q9NR71
EWKTLPAPLDHINLH	MGAM	1696	O43451
PPLEQVWNLLHLEHK	KDM6B	171	O15054
WHDHSSLQPQPLGLK	BEND2	91	Q8NDZ0
PHKQPWPGLAQAHRD	BPIFA3	21	Q9BQP9
HVEPWVQKNPTNHFP	BMP15	151	O95972
AHQPLDAAPVPAHWL	PDZD7	976	Q9H5P4
WCVPHPSKPNHTLVL	GBP6	81	Q6ZN66
DPNGPTHAPWLLAHK	GGA2	56	Q9UJY4
THAPWLLAHKIQSPQ	GGA2	61	Q9UJY4
WCVPHPSKPNHTLIL	GBP7	81	Q8N8V2
AWVPLPTVDVPDHAH	OPN4	56	Q9UHM6
PKPEIIWIHNNHSLD	PXDNL	261	A1KZ92
IWPNVPDPSKSHIAQ	IL6ST	651	P40189
HHLPLPDNWKSQVEP	CPN1	181	P15169
SDPQPHIQWLKHIEV	FGFR1	281	P11362
HPIQWNAPQPSHISK	FN1	626	P02751
LWHPAHLQTLPVTPN	GALNT5	126	Q7Z7M9
QHQEPAKPAVQAPWS	ITSN1	711	Q15811
QPHQWKPPIEREEHR	GON4L	901	Q3T8J9
QPHDKVIDLTPPWEH	DNAJC6	366	O75061
LAQQHLPPLEWDPHP	AKNA	61	Q7Z591
HPPATPIHNQLKAGW	BTBD7	766	Q9P203
PLDHWVFNTEAHPLP	MAN1A2	611	O60476
SEPAFPHHHWKEETP	HBP1	161	O60381
SVNHDPLKWPNPENF	CYP1B1	426	Q16678
VLQDPNTWPSPHKFD	CYP20A1	371	Q6UW02
PPDLSWHPLHQGLND	BMP2KL	326	Q5H9B9
EHGPPHTKNWRPQVL	SLC12A7	681	Q9Y666
KPPWNAEKHSNHLAL	MAP3K1	1446	Q13233
DWRDPHPAVAAQKPH	METTL24	231	Q5JXM2
APNPFHLQLHWASPL	GRIN3B	141	O60391
WTSPLKVTPLQPHHE	SPATA48	186	A4D263
WDHHLPPPAAKTVVE	RNF181	46	Q9P0P0
PWHPKPVLELSDSNA	NXN	306	Q6DKJ4
HPKKAVSPVSPPQHW	SPATA31A6	1306	Q5VVP1
AVPDSWPFHHPVNKK	TAF1	1521	P21675
WHEAQKNPKIRPNPH	ERCC5	896	P28715
LDEPLPPVHHWTSQQ	SAMD14	316	Q8IZD0
HNGPHAPWAPRAQKE	SCRIB	646	Q14160
AIPHQWELPGADPVH	TET1	371	Q8NFU7
TPAWLHHQLLPPPEV	TBX10	301	O75333
TLDDFIPPHLQRWPH	SORBS1	206	Q9BX66
VHEAKPVPENHPQWD	SEC63	716	Q9UGP8
PQHVTETFHPDPNWK	TRAF4	401	Q9BUZ4
PWKDHLTFQPLHPAE	ZNF365	56	Q70YC4
PSRKLWARHHPQVPD	WSB2	106	Q9NYS7
HSTKPHQSLEGPPWL	HIVEP2	111	P31629
HPTINVPPRHALKWI	ZC3H14	716	Q6PJT7
PQDPALWVLHVLPNH	ZMYND15	51	Q9H091
QFPDPAHPNTLHWVD	TFR2	201	Q9UP52
PKLNALNHDPTSPQW	XIRP1	1426	Q702N8
NPQLHKEDEPAWKPV	MYO9A	1691	B2RTY4