Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PROTEIN_KINASE_TYR	PEAK1 PRAG1 ROR2	4.05e-04	97	28	3	PS00109
Domain	Tyr_kinase_AS	PEAK1 PRAG1 ROR2	4.05e-04	97	28	3	IPR008266
Domain	-	SUCO F5	5.33e-03	73	28	2	2.60.120.260
Domain	SH3_2	SHANK1 TJP1	7.33e-03	86	28	2	IPR011511
Domain	SH3_2	SHANK1 TJP1	7.33e-03	86	28	2	PF07653
Domain	SAM	SHANK1 STIM1	7.66e-03	88	28	2	SM00454
Domain	Galactose-bd-like	SUCO F5	8.70e-03	94	28	2	IPR008979
Domain	SAM_DOMAIN	SHANK1 STIM1	8.88e-03	95	28	2	PS50105
Domain	SAM	SHANK1 STIM1	9.24e-03	97	28	2	IPR001660
Domain	-	SHANK1 STIM1	1.10e-02	106	28	2	1.10.150.50
Domain	SAM/pointed	SHANK1 STIM1	1.32e-02	117	28	2	IPR013761
Domain	ARM-type_fold	RALGAPA1 USP34 GBF1	1.39e-02	339	28	3	IPR016024
Domain	C2	C2CD3 BAIAP3	1.64e-02	131	28	2	PF00168
Domain	C2	C2CD3 BAIAP3	1.78e-02	137	28	2	SM00239
Domain	PDZ	SHANK1 TJP1	1.88e-02	141	28	2	PF00595
Domain	C2	C2CD3 BAIAP3	1.91e-02	142	28	2	PS50004
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STIM1 RALGAPA1 C2CD3 GBF1 PEAK1 PRAG1 TJP1 ROR2	4.93e-07	861	30	8	36931259
Pubmed	Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.	PEAK1 PRAG1	7.19e-07	2	30	2	29079850
Pubmed	Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.	PEAK1 PRAG1	7.19e-07	2	30	2	27531744
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO2 CALCA	2.16e-06	3	30	2	37321223
Pubmed	The mouse kinome: discovery and comparative genomics of all mouse protein kinases.	PEAK1 PRAG1	1.08e-05	6	30	2	15289607
Pubmed	The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation.	CALCA TJP1	2.01e-05	8	30	2	16331648
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	STIM1 RALGAPA1 C2CD3 PEAK1 TJP1 SSH3 BCKDK	2.47e-05	1049	30	7	27880917
Pubmed	Molecular staging of epithelial maturation using secretory cell-specific genes as markers.	CALCA TJP1	3.22e-05	10	30	2	18757308
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 MRTFB GBF1 BAIAP3	4.10e-05	225	30	4	12168954
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	SHANK1 RALGAPA1 C2CD3 FAM193A BCKDK	4.39e-05	462	30	5	31138677
Pubmed	Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.	PEAK1 PRAG1	4.72e-05	12	30	2	35192416
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	PIEZO2 CALCA	7.50e-05	15	30	2	37541195
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PEAK1 FAM193A TJP1 ROR2	7.50e-05	263	30	4	34702444
Pubmed	Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.	PIEZO2 CALCA	8.57e-05	16	30	2	28002412
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	RALGAPA1 GBF1 SUPT20H	1.05e-04	106	30	3	31024071
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	STIM1 MRTFB PEAK1 TJP1 SSH3	1.13e-04	565	30	5	25468996
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	STIM1 MRTFB GBF1 TJP1 ROR2	1.16e-04	568	30	5	37774976
Pubmed	Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain.	PIEZO2 CALCA	1.35e-04	20	30	2	36334588
Pubmed	Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.	CALCA TJP1	1.50e-04	21	30	2	23707896
Pubmed	Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.	PIEZO2 CALCA	2.13e-04	25	30	2	35681537
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	STIM1 RALGAPA1 PEAK1 FAM193A SUCO BCKDK ROR2	2.20e-04	1487	30	7	33957083
Pubmed	HIV/AIDS. Persistence by proliferation?	C2CD3 MRTFB	2.31e-04	26	30	2	25013050
Pubmed	The transcription factor c-Maf controls touch receptor development and function.	PIEZO2 CALCA	2.49e-04	27	30	2	22345400
Pubmed	The protein kinase complement of the human genome.	PEAK1 PRAG1	2.68e-04	28	30	2	12471243
Pubmed	Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.	PIEZO2 CALCA	2.88e-04	29	30	2	37192624
Pubmed	Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.	CALCA TJP1	2.88e-04	29	30	2	29874580
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	STIM1 MRTFB SUCO ROR2	2.92e-04	375	30	4	32788342
Pubmed	Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.	PIEZO2 CALCA	3.51e-04	32	30	2	33288908
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	STIM1 GBF1 FAM193A TJP1 HNRNPR	3.57e-04	724	30	5	36232890
Pubmed	Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching.	CALCA TJP1	3.97e-04	34	30	2	32142630
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 TSHZ3 MRTFB FAM193A	4.40e-04	418	30	4	34709266
Pubmed	Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus.	TJP1 ROR2	4.45e-04	36	30	2	30026494
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	MUC16 USP34 GBF1 ROR2	4.48e-04	420	30	4	28065597
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TSHZ3 MRTFB GBF1 FAM193A	4.90e-04	430	30	4	35044719
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SHANK1 STIM1 USP34 GBF1 TJP1 HNRNPR	4.92e-04	1203	30	6	29180619
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	STIM1 MUC16 USP34 PEAK1 TJP1	4.93e-04	777	30	5	35844135
Pubmed	Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.	C2CD3 FAM193A	4.96e-04	38	30	2	36674791
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	STIM1 F5	4.96e-04	38	30	2	16263699
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	C2CD3 FAM193A TJP1	5.32e-04	184	30	3	32908313
Pubmed	Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.	GBF1 HNRNPR	5.50e-04	40	30	2	23825951
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RALGAPA1 GBF1 FAM193A TJP1	5.61e-04	446	30	4	24255178
Pubmed	The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand.	TJP1 ROR2	5.78e-04	41	30	2	26685160
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	RALGAPA1 F5 BCKDK	6.49e-04	197	30	3	20811636
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	SHANK1 TJP1 BCKDK	6.49e-04	197	30	3	36604605
Pubmed	Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.	CALCA F5	6.65e-04	44	30	2	26075897
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	STIM1 MRTFB BCKDK	6.98e-04	202	30	3	29540532
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	MRTFB GBF1 TJP1	8.47e-04	216	30	3	31519766
Interaction	YWHAH interactions	STIM1 RALGAPA1 C2CD3 GBF1 PEAK1 SUCO PRAG1 TJP1 ROR2	1.57e-05	1102	29	9	int:YWHAH
Cytoband	7p22.1	RSPH10B2 RSPH10B	4.38e-04	47	30	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	SUCO F5	3.24e-03	129	30	2	chr1q24
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	RSPH10B2 RSPH10B	3.49e-03	134	30	2	chr7p22
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	C2CD3 BAIAP3	4.55e-04	36	16	2	823
GeneFamily	Sterile alpha motif domain containing	SHANK1 STIM1	2.69e-03	88	16	2	760
GeneFamily	PDZ domain containing	SHANK1 TJP1	7.80e-03	152	16	2	1220
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TSHZ3 PIEZO2 PRAG1 ROR2	8.58e-06	195	30	4	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
Drug	Phthalylsulfathiazole [85-73-4]; Up 200; 10uM; MCF7; HT_HG-U133A	RALGAPA1 NR2E3 F5 BAIAP3 ROR2	4.51e-06	196	29	5	3371_UP
Disease	stem Cell Growth Factor beta measurement	SHANK1 PIEZO2 F5	5.50e-05	75	29	3	EFO_0008292
Disease	inflammatory biomarker measurement	PIEZO2 F5	2.99e-04	26	29	2	EFO_0004872
Disease	autism spectrum disorder (implicated_via_orthology)	SHANK1 TSHZ3 BCKDK	4.44e-04	152	29	3	DOID:0060041 (implicated_via_orthology)
Disease	Intellectual Disability	RALGAPA1 CALCA BCKDK HNRNPR	9.14e-04	447	29	4	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDTLEPVDASSRHSS	BAIAP3	721	O94812
STSATDTHHVEMARE	BCKDK	31	O14874
TEEPETSSHSPSRHM	FAM193A	976	P78312
HLDSMESNTESRPES	NR2E3	131	Q9Y5X4
SPSAVMSHESDAAHS	RSPH10B	676	P0C881
MSHESDAAHSDSARS	RSPH10B	681	P0C881
SPSAVMSHESDAAHS	RSPH10B2	676	B2RC85
MSHESDAAHSDSARS	RSPH10B2	681	B2RC85
DEDTTAIEAMHPSTS	MUC16	6871	Q8WXI7
SHMTHEVTEDFSPRD	PEAK1	1046	Q9H792
EEPMDTSSVTHTEHY	HNRNPR	16	O43390
DHSHSPMETSETQFA	MRTFB	1016	Q9ULH7
LSSHLEPTHELDSMD	C2CD3	1561	Q4AC94
EPTHELDSMDCSSHS	C2CD3	1566	Q4AC94
TSPADHSDSASVHDM	GBF1	361	Q92538
DQMHSTSDPSHRSSS	F5	1136	P12259
VMRSPHSDVGSTDDD	ROR2	566	Q01974
LTHSDSESSLHMSDR	STIM1	516	Q13586
QTHSSAHSDDRMEPR	REELD1	166	A0A1B0GV85
MTHSPATSEDEERHS	SHANK1	1	Q9Y566
TSDMPEVFSSHESSH	SSH3	556	Q8TE77
DMSSDLERDHRPHVS	CALCA	121	P01258
HVSTRMPSDSDDSLT	RALGAPA1	1881	Q6GYQ0
SFSHSDHSSEMSLPE	SPATS1	106	Q496A3
SDSQMSPSHSSTDDH	SUPT20H	376	Q8NEM7
AHRMDSLDSHDSISS	PIEZO2	1736	Q9H5I5
TDTEDEHSHHVMDSV	TTC5	151	Q8N0Z6
SPEYVTTEVHTHDME	SUCO	551	Q9UBS9
TTEVHTHDMEPSTPD	SUCO	556	Q9UBS9
SATITVMAAHPEEDH	PRAG1	471	Q86YV5
EFSCHEMDSESHISE	TSHZ3	66	Q63HK5
RSSEPVREDSSGMHH	TJP1	876	Q07157
DEMLSSHTVPEQSHD	SNAPC5	46	O75971
SHSEDPEHDISGEMN	USP34	696	Q70CQ2