Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZNF317 IKZF5 ZNF260 ZNF17 ZNF684 ZNF483 ZNF347 ZNF66 GMEB1 ZNF816 ZNF888 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	5.43e-06	1412	124	24	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZNF317 IKZF5 ZNF260 ZNF17 ZNF684 ZNF483 ZNF347 ZNF66 GMEB1 ZNF816 ZNF888 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	9.44e-06	1459	124	24	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF254 E4F1 ZNF317 IKZF5 ZNF260 ZNF17 ZNF483 ZNF347 ZNF66 GMEB1 ZNF816 ZNF888 ZNF721 ZNF84 ZFP2	8.02e-05	1244	124	20	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF254 E4F1 ZNF317 IKZF5 ZNF260 ZNF17 ZNF483 ZNF347 ZNF66 GMEB1 ZNF816 ZNF888 ZNF721 ZNF84 ZFP2	1.08e-04	1271	124	20	GO:0000987
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGM	1.14e-04	3	124	2	GO:0008184
GeneOntologyMolecularFunction	translation elongation factor activity	EEF1A1 EEF1A1P5 EEF1A2	2.47e-04	20	124	3	GO:0003746
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGM	3.78e-04	5	124	2	GO:0004645
GeneOntologyMolecularFunction	molybdopterin cofactor binding	AOX1 XDH	5.65e-04	6	124	2	GO:0043546
GeneOntologyMolecularFunction	carbohydrate binding	ATRN GALNT1 DBH NOMO1 NOMO2 PYGB PYGM NOMO3	7.15e-04	310	124	8	GO:0030246
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	1.74e-05	9	124	3	GO:0160063
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	1.63e-05	9	123	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	6.90e-05	14	123	3	GO:0072379
GeneOntologyCellularComponent	eukaryotic translation elongation factor 1 complex	EEF1A1 EEF1A2	2.04e-04	4	123	2	GO:0005853
Domain	-	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	4.41e-11	679	119	23	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	6.81e-11	694	119	23	IPR013087
Domain	zf-C2H2	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	4.22e-10	693	119	22	PF00096
Domain	ZINC_FINGER_C2H2_2	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	5.93e-10	775	119	23	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	6.24e-10	777	119	23	PS00028
Domain	Znf_C2H2-like	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	9.95e-10	796	119	23	IPR015880
Domain	Znf_C2H2	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	1.23e-09	805	119	23	IPR007087
Domain	ZnF_C2H2	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	1.33e-09	808	119	23	SM00355
Domain	zf-C2H2_6	ZSCAN31 E4F1 ZNF317 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF816 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	1.31e-08	314	119	14	PF13912
Domain	DUF2012	NOMO1 NOMO2 NOMO3	1.00e-06	4	119	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	1.00e-06	4	119	3	IPR019008
Domain	KRAB	ZNF484 ZNF337 ZNF254 ZNF317 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF84 ZNF700	3.09e-06	358	119	12	PF01352
Domain	KRAB	ZNF484 ZNF337 ZNF254 ZNF317 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF84 ZNF700	4.21e-06	369	119	12	SM00349
Domain	KRAB	ZNF484 ZNF337 ZNF254 ZNF317 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF84 ZNF700	4.33e-06	370	119	12	IPR001909
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	1.38e-05	8	119	3	IPR013784
Domain	KRAB	ZNF484 ZNF337 ZNF254 ZNF317 ZNF17 ZNF684 ZNF483 ZNF347 ZNF816 ZNF84 ZNF700	1.83e-05	358	119	11	PS50805
Domain	-	AOX1 XDH	4.03e-05	2	119	2	3.30.365.10
Domain	AldOxase/xan_DH_Mopterin-bd	AOX1 XDH	4.03e-05	2	119	2	IPR008274
Domain	Ald_Xan_dh_C	AOX1 XDH	4.03e-05	2	119	2	PF01315
Domain	Fer2_2	AOX1 XDH	4.03e-05	2	119	2	PF01799
Domain	-	AOX1 XDH	4.03e-05	2	119	2	3.90.1170.50
Domain	CO_deh_flav_C	AOX1 XDH	4.03e-05	2	119	2	SM01092
Domain	CO_deh_flav_C	AOX1 XDH	4.03e-05	2	119	2	PF03450
Domain	Mopterin_DH_FAD-bd	AOX1 XDH	4.03e-05	2	119	2	IPR002346
Domain	Ald_Xan_dh_C	AOX1 XDH	4.03e-05	2	119	2	SM01008
Domain	Transl_elong_EF1A_euk/arc	EEF1A1 EEF1A2	4.03e-05	2	119	2	IPR004539
Domain	2Fe-2S-bd	AOX1 XDH	4.03e-05	2	119	2	IPR002888
Domain	FAD_binding_5	AOX1 XDH	4.03e-05	2	119	2	PF00941
Domain	Ald_Oxase/Xan_DH_a/b	AOX1 XDH	4.03e-05	2	119	2	IPR000674
Domain	Ald_Xan_dh_C2	AOX1 XDH	4.03e-05	2	119	2	PF02738
Domain	AP1_complex_gsu	AP1G1 AP1G2	4.03e-05	2	119	2	IPR017107
Domain	CO_DH_flav_C	AOX1 XDH	4.03e-05	2	119	2	IPR005107
Domain	Ald_Oxase/xanthine_DH	AOX1 XDH	4.03e-05	2	119	2	IPR016208
Domain	-	AOX1 XDH	4.03e-05	2	119	2	1.10.150.120
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	6.88e-05	13	119	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	6.88e-05	13	119	3	2.60.40.1120
Domain	-	PLXNA3 FLNC NRCAM CCDC141 TRIM3 NOMO1 IGSF22 NOMO2 IL1R2 FNDC11 KDR ROS1 NOMO3 MYBPC2	8.36e-05	663	119	14	2.60.40.10
Domain	MOLYBDOPTERIN_EUK	AOX1 XDH	1.20e-04	3	119	2	PS00559
Domain	PHOSPHORYLASE	PYGB PYGM	1.20e-04	3	119	2	PS00102
Domain	OxRdtase_Mopterin-bd_dom	AOX1 XDH	1.20e-04	3	119	2	IPR000572
Domain	Glycg_phsphrylas	PYGB PYGM	1.20e-04	3	119	2	IPR011833
Domain	Glyco_trans_35	PYGB PYGM	1.20e-04	3	119	2	IPR000811
Domain	Phosphorylase	PYGB PYGM	1.20e-04	3	119	2	PF00343
Domain	OxRdtase_Mopterin_BS	AOX1 XDH	1.20e-04	3	119	2	IPR022407
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	1.61e-04	17	119	3	IPR008969
Domain	Ig-like_fold	PLXNA3 FLNC NRCAM CCDC141 TRIM3 NOMO1 IGSF22 NOMO2 IL1R2 FNDC11 KDR ROS1 NOMO3 MYBPC2	1.61e-04	706	119	14	IPR013783
Domain	2Fe2S_fd_BS	AOX1 XDH	3.98e-04	5	119	2	IPR006058
Domain	GAE	AP1G1 AP1G2	3.98e-04	5	119	2	PS50180
Domain	-	AOX1 XDH	3.98e-04	5	119	2	3.30.43.10
Domain	FAD-bd_2_sub1	AOX1 XDH	3.98e-04	5	119	2	IPR016167
Domain	2FE2S_FER_1	AOX1 XDH	3.98e-04	5	119	2	PS00197
Domain	-	AP1G1 AP1G2	5.94e-04	6	119	2	2.60.40.1230
Domain	2FE2S_FER_2	AOX1 XDH	5.94e-04	6	119	2	PS51085
Domain	-	AOX1 XDH	5.94e-04	6	119	2	3.30.465.10
Domain	HELP	EML6 EML5	5.94e-04	6	119	2	PF03451
Domain	2Fe-2S_ferredoxin-type	AOX1 XDH	5.94e-04	6	119	2	IPR001041
Domain	Clathrin_g-adaptin_app	AP1G1 AP1G2	5.94e-04	6	119	2	IPR008153
Domain	Fer2	AOX1 XDH	5.94e-04	6	119	2	PF00111
Domain	FAD_PCMH	AOX1 XDH	5.94e-04	6	119	2	PS51387
Domain	CO_DH_flavot_FAD-bd_sub2	AOX1 XDH	5.94e-04	6	119	2	IPR016169
Domain	FAD-bd_2	AOX1 XDH	5.94e-04	6	119	2	IPR016166
Domain	HELP	EML6 EML5	5.94e-04	6	119	2	IPR005108
Domain	Transl_elong_EFTu/EF1A_C	EEF1A1 EEF1A2	1.10e-03	8	119	2	IPR004160
Domain	GTP_EFTU_D3	EEF1A1 EEF1A2	1.10e-03	8	119	2	PF03143
Domain	-	PLXNA3 WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	1.33e-03	333	119	8	2.130.10.10
Domain	WD40	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	1.36e-03	259	119	7	PF00400
Domain	WD40/YVTN_repeat-like_dom	PLXNA3 WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	1.38e-03	335	119	8	IPR015943
Domain	Alpha_adaptinC2	AP1G1 AP1G2	1.41e-03	9	119	2	PF02883
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1G1 AP1G2	1.41e-03	9	119	2	IPR008152
Domain	G_TR_CS	EEF1A1 EEF1A2	1.41e-03	9	119	2	IPR031157
Domain	Alpha_adaptinC2	AP1G1 AP1G2	1.41e-03	9	119	2	SM00809
Domain	WD40	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	1.66e-03	268	119	7	SM00320
Domain	IG_FLMN	FLNC TRIM3	1.75e-03	10	119	2	SM00557
Domain	Transl_elong_EF1A/Init_IF2_C	EEF1A1 EEF1A2	1.75e-03	10	119	2	IPR009001
Domain	WD40_repeat	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	1.80e-03	272	119	7	IPR001680
Domain	WD_REPEATS_1	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	2.04e-03	278	119	7	PS00678
Domain	WD_REPEATS_2	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	2.08e-03	279	119	7	PS50082
Domain	WD_REPEATS_REGION	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	2.08e-03	279	119	7	PS50294
Domain	Filamin	FLNC TRIM3	2.13e-03	11	119	2	PF00630
Domain	FILAMIN_REPEAT	FLNC TRIM3	2.13e-03	11	119	2	PS50194
Domain	Filamin/ABP280_rpt	FLNC TRIM3	2.13e-03	11	119	2	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNC TRIM3	2.13e-03	11	119	2	IPR017868
Domain	FN3_dom	FLNC NRCAM IGSF22 FNDC11 ROS1 MYBPC2	2.22e-03	209	119	6	IPR003961
Domain	Coatomer/clathrin_app_Ig-like	AP1G1 AP1G2	2.55e-03	12	119	2	IPR013041
Domain	WD40_repeat_dom	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	2.95e-03	297	119	7	IPR017986
Domain	G_TR_1	EEF1A1 EEF1A2	3.00e-03	13	119	2	PS00301
Domain	-	AOX1 XDH	3.48e-03	14	119	2	3.10.20.30
Domain	Beta-grasp_dom	AOX1 XDH	3.48e-03	14	119	2	IPR012675
Domain	Clathrin/coatomer_adapt-like_N	AP1G1 AP1G2	4.00e-03	15	119	2	IPR002553
Domain	Adaptin_N	AP1G1 AP1G2	4.00e-03	15	119	2	PF01602
Domain	WD40_repeat_CS	WDR7 EML6 EML5 PRPF19 CFAP44	4.01e-03	164	119	5	IPR019775
Domain	Ig_E-set	PLXNA3 FLNC TRIM3 KCNJ4	4.41e-03	104	119	4	IPR014756
Domain	PKS_ER	FASN CRYZL1	4.56e-03	16	119	2	IPR020843
Domain	PKS_ER	FASN CRYZL1	4.56e-03	16	119	2	SM00829
Domain	Quinoprotein_ADH-like_supfam	WDR7 EML6 EML5	4.69e-03	53	119	3	IPR011047
Domain	Acyl_Trfase/lysoPLipase	FASN PNPLA6	5.14e-03	17	119	2	IPR016035
Domain	EFTu-like_2	EEF1A1 EEF1A2	5.76e-03	18	119	2	IPR004161
Domain	GTP_EFTU_D2	EEF1A1 EEF1A2	5.76e-03	18	119	2	PF03144
Domain	G_TR_2	EEF1A1 EEF1A2	5.76e-03	18	119	2	PS51722
Pubmed	A protein interaction framework for human mRNA degradation.	GIPC1 ATRN ZBTB17 E4F1 ZFPM1 EEF1A1 NOMO1 NOMO2 AP1G2 EXOSC7 EIF3M NOMO3	5.17e-09	347	125	12	15231747
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	4.53e-08	3	125	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	4.53e-08	3	125	3	25576386
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	EEF1A1 NOMO1 EEF1A2 NOMO2 NOMO3	8.72e-08	31	125	5	19136429
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	1.81e-07	4	125	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	1.81e-07	4	125	3	9267806
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNC MAP1B XDH RRAGC EEF1A1 NOMO1 FASN NOMO2 SNX27 NOMO3	5.10e-07	344	125	10	30333137
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	GIPC1 PLXNA3 ATRN KIF18A GALNT1 MAP1B MCFD2 BRCC3 CACHD1 PRSS23 GSR NOMO1 SERPINE2 SLC12A2 NOMO2 PRPF19 EXOSC7	1.51e-06	1201	125	17	35696571
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	KRT14 GARS1 EMILIN1 GSR EEF1A2 FASN SLC12A2 G3BP2 SLTM EXOSC7 EIF3M	1.91e-06	496	125	11	31343991
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	2.50e-06	8	125	3	15257293
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	3.75e-06	9	125	3	36261522
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLNC FAM120B KRT14 NRCAM MAP1B WDR7 DGKZ TRIM3 EEF1A1 EEF1A2 FASN KIDINS220 PNPLA6 AP1G1 G3BP2 SNX27 PYGB PRPF19	3.78e-06	1431	125	18	37142655
Pubmed	Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.	FLNC MAP1B EEF1A1 FASN PYGB KDR EIF3M	4.88e-06	184	125	7	23402259
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	FLNC KRT14 EEF1A1 NOMO1 EEF1A2 FASN NOMO3	6.23e-06	191	125	7	33762435
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	7.32e-06	11	125	3	32820719
Pubmed	Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.	KRT14 MAP1B EEF1A1 EEF1A1P5 EIF3M	7.81e-06	75	125	5	31527668
Pubmed	Functional proteomics mapping of a human signaling pathway.	KIF18A FLNC ZNF484 E4F1 EEF1A1 NOMO1 PHKA2 AP1G1 GMEB1 ZFP2 NOMO3	1.01e-05	591	125	11	15231748
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	EEF1A1 EEF1A2 FASN	1.26e-05	13	125	3	29285303
Pubmed	AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster.	AP1G1 AP1G2	1.28e-05	2	125	2	22389401
Pubmed	Genetics and development of ocular oxidases in the mouse: evidence for a new locus (Eox-1) closely linked with the aldehyde oxidase loci on chromosome 1.	AOX1 IDH1	1.28e-05	2	125	2	3207217
Pubmed	The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling.	ZNF146 ZNF260	1.28e-05	2	125	2	16166646
Pubmed	eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency.	EEF1A1 EEF1A2	1.28e-05	2	125	2	30782564
Pubmed	Miz1 is required for hair follicle structure and hair morphogenesis.	KRT14 ZBTB17	1.28e-05	2	125	2	17635993
Pubmed	Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression.	BRCC3 SLTM	1.28e-05	2	125	2	38470543
Pubmed	Usefulness of immunohistochemical expression analysis of metabolic-related molecules in differentiating between intracranial neoplastic and non-neoplastic lesions.	IDH1 FASN	1.28e-05	2	125	2	23064941
Pubmed	Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis.	ZBTB38 IL1R2	1.28e-05	2	125	2	30343694
Pubmed	Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment.	EEF1A1 EEF1A2	1.28e-05	2	125	2	35741005
Pubmed	The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders.	EEF1A1 EEF1A2	1.28e-05	2	125	2	30370994
Pubmed	The mouse liver aldehyde oxidase locus (Aox).	AOX1 IDH1	1.28e-05	2	125	2	4269806
Pubmed	Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene.	ZNF146 ZNF260	1.28e-05	2	125	2	10449921
Pubmed	New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.	EEF1A1 EEF1A2	1.28e-05	2	125	2	26212729
Pubmed	A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenal.	ATP7B DBH	1.28e-05	2	125	2	12718440
Pubmed	The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.	EEF1A1 EEF1A2	1.28e-05	2	125	2	17825975
Pubmed	Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression.	EEF1A1 EEF1A2	1.28e-05	2	125	2	22095224
Pubmed	Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach.	EEF1A1 EEF1A2	1.28e-05	2	125	2	38220433
Pubmed	Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.	EEF1A1 EEF1A2	1.28e-05	2	125	2	19636410
Pubmed	Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1.	AOX1 IDH1	1.28e-05	2	125	2	518535
Pubmed	Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling.	DGKZ SNX27	1.28e-05	2	125	2	17351151
Pubmed	Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.	PYGB PYGM	1.28e-05	2	125	2	25130497
Pubmed	Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.	EEF1A1 EEF1A2	1.28e-05	2	125	2	7945283
Pubmed	Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.	AOX1 XDH	1.28e-05	2	125	2	25537183
Pubmed	Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.	EEF1A1 EEF1A2	1.28e-05	2	125	2	32347192
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PLXNA3 FLNC KRT14 MAP1B GARS1 EML6 TRIP13 GSR EEF1A1 EEF1A2 FASN ABCB9 PRPF19 KDR ZNF84 TASOR MYBPC2	1.67e-05	1442	125	17	35575683
Pubmed	Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.	EEF1A1 EEF1A1P5 EEF1A2	2.00e-05	15	125	3	8812466
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNC FAM120B MAP1B GARS1 IFI16 TRIP13 RIF1 FASN PNPLA6 AP1G1 SLTM SNX27 PYGB AP1G2 PRPF19 EIF3M	2.91e-05	1353	125	16	29467282
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	FLNC MAP1B GARS1 TRIP13 EEF1A2 FASN G3BP2 EIF3M	2.95e-05	334	125	8	30425250
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF317 ZNF347 ZNF721 ZFP2	2.97e-05	49	125	4	9630514
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	GIPC1 FLNC MAP1B GARS1 DUSP14 BRCC3 IDH1 RRAGC EEF1A1 FASN AP1G1 G3BP2 SLTM PYGB EXOSC7 EIF3M	3.29e-05	1367	125	16	32687490
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	NRCAM DGKZ CCDC168 RIF1 SLC12A2 SNX27	3.39e-05	168	125	6	30631154
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	FLNC KRT14 MAP1B EEF1A1P5 EEF1A2 FASN G3BP2 PRPF19 CFAP44 EIF3M	3.56e-05	558	125	10	27591049
Pubmed	Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals.	AOX1 IDH1	3.84e-05	3	125	2	2895729
Pubmed	Genetic variation of some aldehyde-oxidizing enzymes in the mouse.	AOX1 IDH1	3.84e-05	3	125	2	742739
Pubmed	Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro.	EEF1A1 EEF1A2	3.84e-05	3	125	2	19559761
Pubmed	Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.	KIDINS220 SNX27	3.84e-05	3	125	2	34002021
Pubmed	ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.	ATP7B DBH	3.84e-05	3	125	2	30341172
Pubmed	Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.	AOX1 XDH	3.84e-05	3	125	2	22495427
Pubmed	Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.	DGKZ RASGRP1	3.84e-05	3	125	2	11257115
Pubmed	VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.	GIPC1 KDR	3.84e-05	3	125	2	20434959
Pubmed	Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2.	EEF1A1 EEF1A2	3.84e-05	3	125	2	37429391
Pubmed	Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.	AOX1 XDH	3.84e-05	3	125	2	19500084
Pubmed	MYC in mammalian epidermis: how can an oncogene stimulate differentiation?	KRT14 ZBTB17	3.84e-05	3	125	2	18292777
Pubmed	Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.	FLNC XIRP2	3.84e-05	3	125	2	27206985
Pubmed	A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.	FLNC XIRP2	3.84e-05	3	125	2	23115302
Pubmed	CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking.	AP1G1 AP1G2	3.84e-05	3	125	2	27909244
Pubmed	The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.	EEF1A1 EEF1A2	3.84e-05	3	125	2	18448518
Pubmed	Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma.	IDH1 KDR	3.84e-05	3	125	2	22199315
Pubmed	Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.	FLNC DUSP14 IDH1 FASN	4.06e-05	53	125	4	15306695
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	DGKZ KIDINS220 SNX27	5.75e-05	21	125	3	31541095
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	GIPC1 FLNC MAP1B GARS1 IDH1 TRIP13 GSR EEF1A1 EEF1A2 PHKA2 FASN G3BP2 PRPF19 WDTC1	6.92e-05	1149	125	14	35446349
Pubmed	Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice.	EEF1A1 EEF1A2	7.65e-05	4	125	2	11294870
Pubmed	CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.	RASGRP1 RAPGEF3	7.65e-05	4	125	2	15334074
Pubmed	Murine Hn1 on chromosome 11 is expressed in hemopoietic and brain tissues.	FASN KCNJ4	7.65e-05	4	125	2	9271675
Pubmed	Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.	KRT14 ZBTB17	7.65e-05	4	125	2	22509363
Pubmed	Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes.	NRCAM GARS1	7.65e-05	4	125	2	28355569
Pubmed	VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.	GIPC1 KDR	7.65e-05	4	125	2	28289053
Pubmed	Identification of regulators of chaperone-mediated autophagy.	EEF1A1 EEF1A2	7.65e-05	4	125	2	20797626
Pubmed	Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions.	AP1G1 AP1G2	7.65e-05	4	125	2	22345475
Pubmed	Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development.	EEF1A1 EEF1A2	7.65e-05	4	125	2	15013623
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	ATRN GARS1 CACHD1 TRIP13 EEF1A1 NOMO1 FASN NOMO2 AGA NOMO3	7.77e-05	613	125	10	22268729
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	FLNC ZBTB38 MAST2 CCDC141 EEF1A1 STRADB XIRP2 PYGM MYBPC2	8.17e-05	497	125	9	23414517
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	MAP1B BLZF1 TRIM3 EEF1A1 EEF1A2 FASN AP1G1 G3BP2 PYGB PYGM	8.65e-05	621	125	10	22794259
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	NRCAM CACHD1 MAST2 TASOR WDTC1	1.11e-04	130	125	5	12421765
Pubmed	Analysis of a lung defect in autophagy-deficient mouse strains.	FASN PYGB PYGM	1.11e-04	26	125	3	24275123
Pubmed	Quantitative analysis of PPT1 interactome in human neuroblastoma cells.	MAP1B DBH EEF1A1P5 EEF1A2 FASN G3BP2	1.16e-04	210	125	6	26217791
Pubmed	A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.	RASGRP1 RAPGEF3	1.27e-04	5	125	2	9789079
Pubmed	Genome-wide association study of maternal and inherited loci for conotruncal heart defects.	KCNJ4 FHIT	1.27e-04	5	125	2	24800985
Pubmed	Polymorphism and linkage of glutathione reductase in Mus musculus.	IDH1 GSR	1.27e-04	5	125	2	1180875
Pubmed	The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.	EEF1A1 EEF1A2	1.27e-04	5	125	2	18649364
Pubmed	Identification and characterization of novel clathrin adaptor-related proteins.	AP1G1 AP1G2	1.27e-04	5	125	2	9733768
Pubmed	PEG3 controls lipogenesis through ACLY.	IDH1 FASN	1.27e-04	5	125	2	34048454
Pubmed	Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.	EEF1A1 EEF1A2	1.27e-04	5	125	2	8626763
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	FLNC KRT14 MAP1B IDH1 EEF1A1 FASN PYGB	1.41e-04	312	125	7	37120454
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	PYGB PYGM KDR	1.55e-04	29	125	3	32798765
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	MAP1B DGKZ EEF1A1 EEF1A2 PHKA2 FASN G3BP2	1.56e-04	317	125	7	17620599
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	FLNC GARS1 IDH1 EEF1A1 EEF1A2 FASN SLC12A2 AP1G1 SLTM PYGB PRPF19	1.65e-04	807	125	11	30575818
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	KRT14 GARS1 PPWD1 TRIP13 GSR EEF1A1 EEF1A1P5 RIF1 FASN AP1G1 G3BP2 PRPF19 EXOSC7 MRRF EIF3M	1.76e-04	1415	125	15	28515276
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	GARS1 BRCC3 TRIP13 EEF1A1 NOMO1 EEF1A1P5 EEF1A2 RIF1 FASN NOMO2 G3BP2 PYGB PRPF19 NOMO3	1.77e-04	1257	125	14	37317656
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FLNC FAM120B MAP1B EEF1A1 RIF1 FASN G3BP2 PRPF19 TASOR	1.77e-04	551	125	9	34728620
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	MAP1B IDH1 EEF1A1 NOMO1 EEF1A2 NOMO2 PYGB PYGM NOMO3	1.80e-04	552	125	9	36293380
Pubmed	Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.	AP1G1 AP1G2	1.90e-04	6	125	2	10814529
Interaction	FER1L6 interactions	EEF1A1 EEF1A1P5 EEF1A2	7.08e-06	7	120	3	int:FER1L6
Interaction	AADAT interactions	MCFD2 IDH1 GSR AGA	9.70e-06	23	120	4	int:AADAT
Interaction	CKMT2 interactions	MAP1B IKZF5 EEF1A2 XIRP2 G3BP2 PYGM	1.25e-05	86	120	6	int:CKMT2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB38 ZNF146 ZBTB17 ZSCAN31 ZNF484 ZNF337 ZNF254 E4F1 ZFPM1 ZNF317 IKZF5 ZNF260 ZNF17 PRDM9 ZNF684 ZNF483 ZNF347 ZNF816 ZNF888 ZNF721 ZNF80 ZNF84 ZNF700 ZFP2	6.01e-15	718	82	24	28
GeneFamily	Glycogen phosphorylases	PYGB PYGM	6.08e-05	3	82	2	437
GeneFamily	WD repeat domain containing	WDR7 EML6 PPWD1 EML5 PRPF19 CFAP44 WDTC1	1.87e-04	262	82	7	362
Computational	Metal ion (zinc) binding.	ZNF146 GALNT1 AOX1 FASN PAH CRYZL1	9.08e-07	45	80	6	MODULE_280
Computational	Genes in the cancer module 286	XDH IDH1 FASN CRYZL1	1.56e-04	37	80	4	MODULE_286
Drug	4-pyridoxic acid	AOX1 GSR PAH PYGB PYGM	1.32e-07	23	123	5	CID000006723
Drug	Ap4U	XDH PYGB PYGM FHIT	3.88e-07	12	123	4	CID000165888
Drug	3'-chloromethotrexate	AOX1 PYGB PYGM	6.13e-07	4	123	3	CID000097703
Drug	ADP alpha S	PYGB PYGM FHIT WDTC1	2.95e-06	19	123	4	CID000171069
Drug	formycins	AOX1 PYGB PYGM	5.30e-06	7	123	3	CID000512867
Drug	benznidazole	AOX1 XDH GSR RIF1	5.50e-06	22	123	4	CID000031593
Drug	diphenyl sulfoxide	AOX1 XDH DBH GSR	5.50e-06	22	123	4	CID000013679
Drug	nicotinamide ribose	IDH1 GSR FASN NRK PYGB PYGM	5.51e-06	82	123	6	CID000000940
Drug	dimethyldithiocarbamate	PLXNA3 AOX1 DBH RIF1	6.63e-06	23	123	4	CID000006599
Drug	5-hydroxypyrazinoic acid	AOX1 XDH	2.89e-05	2	123	2	CID000161825
Drug	5-hydroxypyrazinamide	AOX1 XDH	2.89e-05	2	123	2	CID000151823
Drug	NSC-13158	AOX1 GSR RIF1	4.23e-05	13	123	3	CID000079470
Drug	sodium nitrate	XDH GSR PYGB PYGM	4.67e-05	37	123	4	ctd:C031618
Drug	isoxanthopterin	AOX1 XDH PAH	5.36e-05	14	123	3	CID000010729
Drug	butylethanolamine	PHKA2 PYGB PYGM	8.18e-05	16	123	3	CID000249006
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGM	8.65e-05	3	123	2	CID000521488
Drug	2-hydroxypurine	AOX1 XDH	8.65e-05	3	123	2	CID000075323
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGM	8.65e-05	3	123	2	CID000147839
Drug	2-thio-FAD	XDH GSR	8.65e-05	3	123	2	CID003037577
Drug	NSC758405	PYGB PYGM	8.65e-05	3	123	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGM	8.65e-05	3	123	2	CID000151920
Drug	pyridoxal phosphoglucose	PYGB PYGM	8.65e-05	3	123	2	CID000196007
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGM	8.65e-05	3	123	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGM	8.65e-05	3	123	2	CID000191554
Drug	hydan	PYGB PYGM	8.65e-05	3	123	2	CID000008360
Drug	EHMF	PYGB PYGM	8.65e-05	3	123	2	CID000033931
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGM	8.65e-05	3	123	2	CID003082249
Drug	Plp 5'-mpa	PYGB PYGM	8.65e-05	3	123	2	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGB PYGM	8.65e-05	3	123	2	CID000191723
Drug	3'-FFdUrd	PYGB PYGM	8.65e-05	3	123	2	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGM	8.65e-05	3	123	2	CID000119518
Drug	AC1L8XK3	PYGB PYGM	8.65e-05	3	123	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGM	8.65e-05	3	123	2	CID000446801
Drug	riboflavin tetraacetate	PYGB PYGM	8.65e-05	3	123	2	CID000094186
Drug	2,5-dimethyl-3-furanone	PYGB PYGM	8.65e-05	3	123	2	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGM	8.65e-05	3	123	2	CID000011459
Drug	Amphotericin B [1397-89-3]; Down 200; 4.4uM; MCF7; HT_HG-U133A	PLXNA3 KIF18A ATP7B AOX1 MAST2 TRIM3 ABCB9	9.03e-05	194	123	7	3303_DN
Drug	benzylacyclouridine	AOX1 RIF1 PYGB PYGM	9.32e-05	44	123	4	CID000054929
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	GIPC1 KIF18A ATP7B ZNF337 MCFD2 OSGEPL1 AGA	9.33e-05	195	123	7	5315_DN
Drug	NDPhA	PLXNA3 AOX1 GSR	9.90e-05	17	123	3	CID000006838
Drug	Bethanechol chloride [590-63-6]; Down 200; 20.4uM; MCF7; HT_HG-U133A	PLXNA3 FLNC MAP1B MAST2 KIDINS220 ABCB9 G3BP2	1.03e-04	198	123	7	3537_DN
Drug	Ketorolac tromethamine [74103-07-4]; Up 200; 10.6uM; HL60; HT_HG-U133A	NRCAM XDH BLZF1 RIF1 KCNJ4 AP1G2 SNTB1	1.03e-04	198	123	7	3110_UP
Drug	Isoxicam [34552-84-6]; Down 200; 12uM; HL60; HT_HG-U133A	GIPC1 KIF18A IKZF5 SERPINE2 IL1R2 FHIT SNTB1	1.03e-04	198	123	7	1862_DN
Drug	galocitabine	PYGB PYGM	1.72e-04	4	123	2	CID000065950
Drug	AC1L212F	AOX1 XDH	1.72e-04	4	123	2	CID000013118
Drug	5-deoxyribose-1-phosphate	PYGB PYGM	1.72e-04	4	123	2	CID000135786
Drug	ingliforib	PYGB PYGM	1.72e-04	4	123	2	CID006451325
Drug	uric acid riboside	PYGB PYGM	1.72e-04	4	123	2	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGM	1.72e-04	4	123	2	CID000125259
Drug	pyridoxal diphosphate	PYGB PYGM	1.72e-04	4	123	2	CID000125696
Drug	AC1L3UXH	AOX1 XDH	1.72e-04	4	123	2	CID000065446
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGM	1.72e-04	4	123	2	CID000189134
Drug	AC1LAMW2	PYGB PYGM	1.72e-04	4	123	2	CID000491364
Drug	FdUrd-C8	PYGB PYGM	1.72e-04	4	123	2	CID000094262
Drug	U273	PLXNA3 GSR	1.72e-04	4	123	2	CID000008407
Drug	Mem-CC	PYGB PYGM	1.72e-04	4	123	2	CID003081269
Drug	picrolonic acid	AOX1 XDH	1.72e-04	4	123	2	CID000068369
Drug	BCIp4A	PYGB PYGM	1.72e-04	4	123	2	CID000192417
Disease	developmental and epileptic encephalopathy 33 (implicated_via_orthology)	EEF1A1 EEF1A1P5 EEF1A2	6.23e-08	3	118	3	DOID:0080463 (implicated_via_orthology)
Disease	xanthinuria (implicated_via_orthology)	AOX1 XDH	1.59e-05	2	118	2	DOID:0060236 (implicated_via_orthology)
Disease	unipolar depression, depressive symptom measurement	ZSCAN31 RASGRP1 FHIT	1.52e-04	26	118	3	EFO_0003761, EFO_0007006
Disease	dilated cardiomyopathy (implicated_via_orthology)	FLNC EEF1A1 EEF1A1P5 EEF1A2	3.04e-04	80	118	4	DOID:12930 (implicated_via_orthology)
Disease	Asperger syndrome	SLTM FHIT	3.29e-04	7	118	2	EFO_0003757
Disease	Carcinomatosis	ATP7B XDH EEF1A1 SLC12A2 FHIT	5.12e-04	163	118	5	C0205699
Disease	Carcinoma, Spindle-Cell	ATP7B XDH EEF1A1 SLC12A2 FHIT	5.12e-04	163	118	5	C0205697
Disease	Undifferentiated carcinoma	ATP7B XDH EEF1A1 SLC12A2 FHIT	5.12e-04	163	118	5	C0205698
Disease	Anaplastic carcinoma	ATP7B XDH EEF1A1 SLC12A2 FHIT	5.12e-04	163	118	5	C0205696
Disease	epilepsy (implicated_via_orthology)	NRCAM EEF1A1 EEF1A1P5 EEF1A2 SLC12A2	5.12e-04	163	118	5	DOID:1826 (implicated_via_orthology)
Disease	Carcinoma	ATP7B XDH EEF1A1 SLC12A2 FHIT	5.26e-04	164	118	5	C0007097
Disease	spinal muscular atrophy (implicated_via_orthology)	ATP7B GARS1	5.60e-04	9	118	2	DOID:12377 (implicated_via_orthology)
Disease	fibroblast growth factor basic measurement	MAP1B ADCK1 SERPINE2	1.72e-03	59	118	3	EFO_0008130
Disease	Glycogen storage disease	PHKA2 PYGM	2.07e-03	17	118	2	cv:C0017919
Disease	urolithiasis	GIPC1 ZFPM1 SLC30A10	2.08e-03	63	118	3	MONDO_0024647
Disease	hypertension (biomarker_via_orthology)	XDH DBH SERPINE2 SLC12A2 KDR	2.23e-03	227	118	5	DOID:10763 (biomarker_via_orthology)
Disease	Dyschondroplasias	IDH1 KDR	2.59e-03	19	118	2	C0013366
Disease	response to methotrexate, neurotoxicity	GIPC1 PNPLA6	2.59e-03	19	118	2	EFO_0011057, GO_0031427
Disease	dilated cardiomyopathy	FLNC ZBTB17	2.87e-03	20	118	2	EFO_0000407
Disease	muscular dystrophy (implicated_via_orthology)	TRIM3 SNTB1	3.17e-03	21	118	2	DOID:9884 (implicated_via_orthology)
Disease	juvenile idiopathic arthritis	NRCAM GARS1 FASN	3.29e-03	74	118	3	EFO_0002609
Disease	portal hypertension (biomarker_via_orthology)	XDH DBH	3.48e-03	22	118	2	DOID:10762 (biomarker_via_orthology)
Disease	urinary bladder cancer (is_implicated_in)	XDH KDR FHIT	3.54e-03	76	118	3	DOID:11054 (is_implicated_in)
Disease	Epilepsy, Benign Psychomotor, Childhood	SLC12A2 KDR	3.80e-03	23	118	2	C0393672
Disease	Epilepsy, Lateral Temporal	SLC12A2 KDR	3.80e-03	23	118	2	C0393682
Disease	Uncinate Epilepsy	SLC12A2 KDR	3.80e-03	23	118	2	C0014558
Disease	Epilepsy, Temporal Lobe	SLC12A2 KDR	3.80e-03	23	118	2	C0014556
Disease	Malignant neoplasm of breast	KRT14 ATP7B NRCAM MFSD9 XDH RIF1 FASN SERPINE2 G3BP2 KDR EIF3M	3.90e-03	1074	118	11	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
VIVQDSAGRSKSVHH	TMEM62	391	Q0P6H9
LAQVHKAVLHDGRTV	ADCK1	166	Q86TW2
SINAHGSVLIKATHV	ATP7B	876	P35670
NLTKSHIEIIRGHAA	GSR	161	P00390
ISRLKETSSHVPHEI	RASGRP1	306	O95267
DTILHVLTTAGTHVR	AP1G2	421	O75843
SKHIVVILDHGASVT	CACHD1	226	Q5VU97
DTVADKIHSVSRKHG	DUSP14	91	O95147
KEGSVIDHIHLISVG	GIPC1	161	O14908
VTAVVTLREGHSLSH	ACSF3	516	Q4G176
TIVVHAILSDHKISS	CFAP44	1031	Q96MT7
VTTVEGIGSTHTRIH	AOX1	86	Q06278
LTAIRHHVLGTITTD	NOMO3	661	P69849
AIQLAHHRGAKVIST	CRYZL1	161	O95825
LFSHHAVISVRDGKL	KCNJ4	186	P48050
KNHGVLHTSVVLLTE	AP1G1	186	O43747
AKLGLSVFTHHRVES	MMTAG2	141	Q9BU76
LGEAIHSQTEVHLKT	OSGEPL1	61	Q9H4B0
SRVLLHHAKAGTIIA	PNPLA6	526	Q8IY17
LTAIRHHVLGTITTD	NOMO2	661	Q5JPE7
ISASKEGHVHIVEEL	KIDINS220	76	Q9ULH0
GQKILHHRSDVLETV	MAP1B	96	P46821
LELSTAITHVHKEEG	MCFD2	91	Q8NI22
VAVETHTIHKIEEGI	GMEB1	66	Q9Y692
HTIHKIEEGIDTGTI	GMEB1	71	Q9Y692
KSVEVTSGVQSRKHH	BLZF1	31	Q9H2G9
KTHVLLGRSHDTVQE	MFSD9	236	Q8NBP5
LGAIHHTISVRVKAA	NRCAM	346	Q92823
HDGKVVSTHEQVLRT	KRT14	456	P02533
EDTQKGVVVHGLTLH	KIF18A	181	Q8NI77
GHSAHIVTLKNGRVV	ATRN	446	O75882
KVVVSHSTHRTFGKQ	EIF3M	331	Q7L2H7
ISLEGVHVVDSREKH	FRMD8P1	296	Q9BZ68
TTLTHLAVHRVTGEV	PLXNA3	31	P51805
RHKALSTCVSHITVV	OR4C46	231	A6NHA9
GEHVVSVRKSGKHVT	FLNC	2011	Q14315
ERHLKVHTDTLSGVC	ZFPM1	336	Q8IX07
LTAIRHHVLGTITTD	NOMO1	661	Q15155
VLKHTAFAHLREVGS	HEXD	96	Q8WVB3
KITTGSENLHVSHIL	SERPINE2	326	P07093
RVGKVLHASLQSVVH	EXOSC7	261	Q15024
SKGTARLIEHIRIHT	IKZF5	91	Q9H5V7
KILRHDIGATVHELS	PAH	96	P00439
VHVEVHQRGSSTAKK	TRIP13	21	Q15645
KILVTHFVLTGLTDH	OR5AC1	6	P0C628
KSDVITHQRTHTGEK	PRDM9	536	Q9NQV7
VVRAHESAVTGLSLH	PRPF19	301	Q9UMS4
IVTCSHVGHVFRKAT	GALNT1	336	Q10472
TTQRVGTVVEKHFHG	FHIT	61	P49789
KTVEAEAAHGTVTRH	IDH1	301	O75874
ALAAHAITVKVGHTA	IGSF22	611	Q8N9C0
VEKSTALHRISAEHP	CCDC141	1306	Q6ZP82
HRLVSDVSATKIPHI	FNDC11	186	Q9BVV2
KIRHVDAHATLSDGV	G3BP2	76	Q9UN86
THINIVVIGHVDSGK	EEF1A2	6	Q05639
THINIVVIGHVDSGK	EEF1A1	6	P68104
LHTHLTGRKVVTVLV	DBH	411	P09172
HGLRVVVVTAEKIVH	CPPED1	276	Q9BRF8
NTGELRSVIHSHIKV	IFI16	746	Q16666
HGLVHTEVVELILKS	MAST2	1166	Q6P0Q8
AIGVARKVLEHTTHT	AGA	111	P20933
RKVLEHTTHTLLVGE	AGA	116	P20933
THINIVVIGHVDSGK	EEF1A1P5	6	Q5VTE0
QTISVLKDVHTHGIA	EML5	96	Q05BV3
QTVSLLKDVHTHGVA	EML6	96	Q6ZMW3
LLSAVLTGHRHEKVE	EMILIN1	916	Q9Y6C2
IHLVTDAKGTVIHEV	E4F1	321	Q66K89
RISHIGETVHRESVV	CCDC168	5336	Q8NDH2
LLHHAVSTGSKDVVR	DGKZ	826	Q13574
KVSVHVIEGDHRTLL	FASN	2471	P49327
VSDTEILKVARTHHV	FAM120B	571	Q96EK7
TISIHEVGHTGVTKT	PHKA2	981	P46019
TISEEGHKHVLIVAD	NYNRIN	1626	Q9P2P1
RTSLIVHVRIHSGDK	ZNF146	196	Q15072
HVVESLTRHLTGIIK	NRK	321	Q7Z2Y5
VSVSTQAGHRHETKV	SYT8	156	Q8NBV8
EIHSPDAKHTVILRS	SNTB1	266	Q13884
KAIHEVFEVGVTSHR	RRAGC	361	Q9HB90
RSAEVGKHLAHILLS	TMCO4	376	Q5TGY1
LVVHSAQKVHLRGAT	RIF1	191	Q5UIP0
GTVSGIAVDTHVHRI	NTHL1	231	P78549
TGTLVAEKHVLTAAH	PRSS23	161	O95084
VKHFRSHLGVIESIA	PPWD1	126	Q96BP3
VKELSEALTRHGVSH	GARS1	631	P41250
HRTELHGQLISVEKV	SLTM	446	Q9NWH9
VSEVTLKTVHERQHG	MRRF	26	Q96E11
EKFLSVRGTTHLLVH	IL1R2	181	P27930
VAISTSEVGTDHKLH	TASOR	856	Q9UK61
KHTVLIIAHRLSTVE	ABCB9	691	Q9NP78
TVAEKVDAVRIVHIH	BRCC3	61	P46736
TTSPETVAAKRLHHV	XIRP2	2456	A4UGR9
TVAAKRLHHVLAASE	XIRP2	2461	A4UGR9
DASTKIREIFHHAGI	SLC30A10	361	Q6XR72
VNVVTHGKGLVTTLH	RAPGEF3	291	O95398
ILITGAADSKVHVHD	WDTC1	106	Q8N5D0
TSVLVTHQRIHTGEK	ZNF684	311	Q5T5D7
TSAKILQIHARTHIG	ZNF700	686	Q9H0M5
SSVLIEHQRIHTGEK	ZSCAN31	251	Q96LW9
VSHAISVNHVKRAIA	USP45	41	Q70EL2
ITSLIVHVRIHTGDK	ZNF260	316	Q3ZCT1
HAVNGVARIHSEILK	PYGM	451	P11217
ISTTLTKHRRIHTGE	ZNF721	276	Q8TF20
LQHSIRLSGVEDHVK	SLC12A2	771	P55011
HAVNGVARIHSEIVK	PYGB	451	P11216
SRRKGHVITAISITH	SNX27	436	Q96L92
HHVAVTTVEGIGSTK	XDH	81	P47989
TGHTDIVTHVKLLVN	ROS1	776	P08922
EKSELIRHQTIHTGE	ZNF84	386	P51523
RSSLAIHLVIHTGEK	ZNF347	441	Q96SE7
ENSALLVHKTIHTGE	ZNF888	421	P0CJ79
SVFIQHRVTHTGEKL	ZNF80	146	P51504
VNVGDLSKHIIIHTG	ZBTB17	596	Q13105
KDIGEIVHVNTHLVS	ZNF484	156	Q5JVG2
LIVRGHEVTVLTHSK	UGT2A3	46	Q6UWM9
SRSSILVEHLKIHTG	ZNF483	701	Q8TF39
RSSILTTHKIIHTGE	ZNF66	436	Q6ZN08
IHRSIKASHILISGD	STRADB	181	Q9C0K7
LESNHTIKAGHVLTI	KDR	371	P35968
TLNETLKIHERIHTG	ZBTB38	1076	Q8NAP3
KHFTGRSSLTVHQVI	ZFP2	361	Q6ZN57
RSSLTVHQVIHTGEK	ZFP2	366	Q6ZN57
ITTIAKEVHRHTALA	WDR7	1271	Q9Y4E6
HVKTHRGEKLFVSSV	ZNF317	576	Q96PQ6
TSTLIIHQRVHTGEK	ZNF17	426	P17021
STLTTHEIIHAGEKL	ZNF254	251	O75437
TGEVIHTGTLQRHKS	ZNF816	81	Q0VGE8
HGTVLLRDVVEQHKA	TRIM3	146	O75382
IRAKVAHVIGLLASH	ULK4	526	Q96C45
SKSDLTVHERIHTGE	ZNF337	696	Q9Y3M9
ISHVGRFHKLVIDDV	MYBPC2	486	Q14324