Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor binding

GRM5 ARAP1

9.45e-0333792GO:0001664
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

ZSWIM4 ZSWIM5

1.76e-044792GO:0031462
DomainSWIM

ZSWIM4 ZSWIM5

4.33e-06792PF04434
DomainZF_SWIM

ZSWIM4 ZSWIM5

7.42e-06992PS50966
DomainZnf_SWIM

ZSWIM4 ZSWIM5

7.42e-06992IPR007527
DomainAnk_2

ANKMY1 GLS

4.50e-0321592PF12796
DomainAnk

ANKMY1 GLS

5.05e-0322892PF00023
Domain-

ANKMY1 GLS

5.94e-03248921.25.40.20
DomainANK

ANKMY1 GLS

6.09e-0325192SM00248
DomainANK_REPEAT

ANKMY1 GLS

6.18e-0325392PS50088
DomainAnkyrin_rpt-contain_dom

ANKMY1 GLS

6.23e-0325492IPR020683
DomainANK_REP_REGION

ANKMY1 GLS

6.23e-0325492PS50297
DomainAnkyrin_rpt

ANKMY1 GLS

6.61e-0326292IPR002110
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

GRM5 GLS

1.43e-0314062M42572
PathwayREACTOME_NEURONAL_SYSTEM

GRM5 GLS

7.93e-0333562MM14503
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GRM5 GLS

9.46e-0336762M48346
PathwayREACTOME_NEURONAL_SYSTEM

GRM5 GLS

1.18e-0241162M735
Pubmed

Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.

ZSWIM4 ZSWIM5

1.02e-05199228433741
GeneFamilyZinc fingers SWIM-type|Mitogen-activated protein kinase kinase kinases

ZSWIM4 ZSWIM5

6.16e-0698290
GeneFamilyAnkyrin repeat domain containing

ANKMY1 GLS ARAP1

1.26e-0424283403
ToppCellmoderate-Epithelial-unknown_epithelial|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FAM27D1 GLS

3.67e-04130102a04057bd4f256d09eca06b8c1e8b41425bb4ef3f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP1 ZSWIM5

4.14e-041381026b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCellSmart-seq2-blood_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ANKMY1 ZSWIM5

4.20e-04139102a542ef99ba57f364ea9707b3119e11f5a240034c
ToppCellfacs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKMY1 GRM5

4.50e-041441028bd042f12186f36bc5aabf6a0232270a448f4b58
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

GLS RNF213

5.28e-041561021545169694f686d28648a68b552c2ae606599d66
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

GLS RNF213

6.33e-041711022e9a20f8980b78325c52065a9c14ab3656267c05
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM4 OXA1L

6.56e-04174102ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GRM5 GLS

6.86e-04178102a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

GLS RNF213

7.09e-04181102f2315414e714ac86211546a935660c4be6e85f1b
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-NK_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RNF213 ZSWIM5

7.56e-041871023301e0fca8c436d136c71f1a8fd59b3bb11bdd83
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

GLS RNF213

7.65e-04188102ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

GLS RNF213

7.65e-04188102eadcf90b526be8fe567267da83966c8802608030
ToppCellAdult|World / Lineage, Cell type, age group and donor

ARAP1 RNF213

7.73e-041891025cd285bfad973125d46d704fec18b21266a63379
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

GLS RNF213

7.97e-0419210247646d7e4990be85072987f92bf18d52f8da752e
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

GRM5 GLS

8.14e-041941028aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM5 GLS

8.30e-04196102676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM5 GLS

8.47e-04198102c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM5 GLS

8.47e-041981020ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM5 GLS

8.47e-041981028ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM5 GLS

8.47e-041981026d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM5 GLS

8.47e-041981024ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARAP1 RNF213

8.47e-04198102ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RNF213 ZSWIM5

8.56e-0419910263e632b06e13d2bcde5a00a51962bafdf60fd6c6
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARAP1 RNF213

8.56e-04199102155b03b859157013e9142e9248551369127d9204
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

GLS RNF213

8.56e-04199102cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

GLS RNF213

8.56e-04199102f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellVE|World / Condition, Cell_class and T cell subcluster

GLS RNF213

8.64e-042001028ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellPBMC-Severe-cDC_9|Severe / Compartment, Disease Groups and Clusters

RNF213 MAGEF1

8.64e-04200102ea3b22126d9dfd158bb3c3e1323b30514d721ded
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

GRM5 GLS

8.64e-0420010248d801219bc771d6c7e151dc88ca4c179988de85
DrugMebeverine hydrochloride [2753-45-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

ANKMY1 GLS ARAP1

7.10e-051951036795_DN
DrugScoulerine [6451-73-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

ANKMY1 ARAP1 MAGEF1

7.21e-051961035111_DN
DrugCefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; PC3; HT_HG-U133A

ANKMY1 GLS ARAP1

7.21e-051961033686_DN
DrugD-cycloserine [68-41-7]; Down 200; 39.2uM; HL60; HT_HG-U133A

ANKMY1 GLS MAGEF1

7.32e-051971036139_DN
DrugSulfaquinoxaline sodium salt [967-80-6]; Down 200; 12.4uM; MCF7; HT_HG-U133A

ANKMY1 GLS MAGEF1

7.32e-051971036788_DN
Drug0198306-0000 [212631-61-3]; Up 200; 10uM; MCF7; HT_HG-U133A

ANKMY1 GLS ARAP1

7.43e-051981037064_UP
Drugrotenone; Down 200; 1uM; MCF7; HT_HG-U133A

ANKMY1 GLS ARAP1

7.43e-051981035915_DN
DrugPaclitaxel [33069-62-4]; Down 200; 4.6uM; MCF7; HT_HG-U133A

ANKMY1 GLS ARAP1

7.54e-051991031542_DN
DrugPyrazinamide [ 98-96-4]; Down 200; 32.4uM; PC3; HT_HG-U133A

GLS ARAP1 MAGEF1

7.54e-051991036617_DN
DrugAustricine [10180-88-8]; Down 200; 14.2uM; MCF7; HT_HG-U133A

ANKMY1 GLS ARAP1

7.66e-052001034797_DN
DrugAmmonia

GRM5 GLS

1.94e-0448102ctd:D000641
Drugwortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A

ANKMY1 GLS

2.77e-031831021668_UP
DrugEllipticine [519-23-3]; Up 200; 16.2uM; MCF7; HT_HG-U133A

GLS ARAP1

2.80e-031841022758_UP
DrugLycorine hydrochloride [2188-68-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A

GLS ARAP1

2.86e-031861026051_DN
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

GLS ARAP1

2.89e-031871026995_UP
DrugGSK-3beta Inhibitor VIII; Down 200; 10uM; PC3; HT_HG-U133A

GLS MAGEF1

2.92e-031881027097_DN
DrugAmitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; HL60; HT_HG-U133A

ARAP1 MAGEF1

2.92e-031881021865_DN
DrugRauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ANKMY1 GLS

2.98e-031901026274_DN
DrugThioguanosine [85-31-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A

GLS ARAP1

2.98e-031901022619_UP
DrugBenoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A

ANKMY1 GLS

2.98e-031901024115_DN
DrugProstaglandin E1; Up 200; 10uM; PC3; HT_HG-U133A

GLS MAGEF1

2.98e-031901026571_UP
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A

ANKMY1 MAGEF1

3.01e-031911024289_DN
Drugrosiglitazone maleate; Up 200; 10uM; PC3; HG-U133A

GLS ARAP1

3.01e-03191102430_UP
DrugAntimycin A [1397-94-0]; Down 200; 7.2uM; MCF7; HT_HG-U133A

ARAP1 MAGEF1

3.01e-031911022261_DN
DrugImipenem [74431-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

GLS MAGEF1

3.01e-031911025997_DN
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

GLS MAGEF1

3.01e-031911026184_DN
DrugPinacidil [85371-64-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A

ANKMY1 ARAP1

3.01e-031911025456_DN
DrugLuteolin [491-70-3]; Down 200; 14uM; PC3; HT_HG-U133A

ANKMY1 MAGEF1

3.01e-031911026658_DN
Drugclozapine; Down 200; 10uM; HL60; HT_HG-U133A

ARAP1 MAGEF1

3.04e-031921026188_DN
DrugAmbroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; HL60; HG-U133A

GLS ARAP1

3.04e-031921021623_DN
DrugAtropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; HL60; HG-U133A

GLS MAGEF1

3.08e-031931021768_DN
DrugSTOCK1N-35215; Down 200; 10uM; MCF7; HT_HG-U133A

ARAP1 MAGEF1

3.08e-031931026422_DN
DrugCP-690334-01 [459212-38-5]; Down 200; 10uM; PC3; HT_HG-U133A

ANKMY1 MAGEF1

3.08e-031931024558_DN
DrugCephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A

GLS ARAP1

3.08e-031931023258_DN
DrugAjmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A

GLS ARAP1

3.08e-031931022899_UP
Drugcis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Up 200; 100uM; MCF7; HT_HG-U133A_EA

GLS ARAP1

3.08e-03193102881_UP
DrugChlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; PC3; HT_HG-U133A

GLS ARAP1

3.08e-031931025074_DN
DrugSuloctidil [54063-56-8]; Down 200; 11.8uM; HL60; HT_HG-U133A

ARAP1 MAGEF1

3.08e-031931021297_DN
DrugButirosin disulfate salt [51022-98-1]; Down 200; 5.4uM; MCF7; HT_HG-U133A

ANKMY1 GLS

3.11e-031941026779_DN
DrugMemantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A

ANKMY1 ARAP1

3.11e-031941027354_DN
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

ARAP1 MAGEF1

3.11e-031941025599_DN
DrugDirithromycin [62013-04-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

ANKMY1 GLS

3.11e-031941022863_UP
DrugNifedipine [21829-25-4]; Down 200; 11.6uM; HL60; HT_HG-U133A

GLS ARAP1

3.11e-031941021856_DN
DrugViomycin sulfate [37883-00-4]; Down 200; 5.2uM; MCF7; HT_HG-U133A

ANKMY1 MAGEF1

3.11e-031941027036_DN
DrugImidurea [39236-46-9]; Down 200; 10.4uM; PC3; HT_HG-U133A

ARAP1 MAGEF1

3.11e-031941025062_DN
DrugSpiramycin [8025-81-8]; Down 200; 4.8uM; MCF7; HT_HG-U133A

GLS ARAP1

3.11e-031941023938_DN
DrugThalidomide [50-35-1]; Up 200; 15.4uM; PC3; HT_HG-U133A

ANKMY1 ARAP1

3.14e-031951027288_UP
Diseaseinsulin measurement

GRM5 ARAP1

2.82e-0326792EFO_0004467
Diseasemean platelet volume

ANKMY1 GLS ARAP1

2.96e-03102093EFO_0004584
Diseasehypertension

GRM5 RNF213

3.70e-0330792EFO_0000537
Diseaserheumatoid arthritis

GRM5 ARAP1

8.19e-0346292EFO_0000685

Protein segments in the cluster

PeptideGeneStartEntry
MMRLRGSGMLRDLLL

GLS

1

O94925
MTVRGLLMAMRRLGL

GRM5

281

P41594
RLGLLMMILGLIYMR

MAGEF1

166

Q9HAY2
MAMGLMCGRRELLRL

OXA1L

1

Q15070
GTMRRMALSMIERRK

ANKMY1

511

Q9P2S6
MLEKRLLRMGMRLQL

FAM27D1

1

Q5T7N8
LMDMGMLLPGHRRRI

ARAP1

46

Q96P48
RMRRVMEELPLMLLS

RNF213

1756

Q63HN8
MLRMRDSNGARMLTL

ZSWIM5

371

Q9P217
MLRMRDSNGARMLIL

ZSWIM4

291

Q9H7M6