Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	clathrin light chain binding	CLTCL1 CLTC	2.66e-04	7	72	2	GO:0032051
GeneOntologyMolecularFunction	G protein-coupled acetylcholine receptor activity	CHRM1 CHRM5	2.66e-04	7	72	2	GO:0016907
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	1.35e-05	2	69	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	1.35e-05	2	69	2	PF09268
Domain	-	CLTCL1 CLTC	1.35e-05	2	69	2	2.130.10.110
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	1.35e-05	2	69	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	1.35e-05	2	69	2	PF01394
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	1.35e-05	2	69	2	IPR016341
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	1.35e-05	2	69	2	IPR015348
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	1.35e-05	2	69	2	IPR001473
Domain	ARM-type_fold	PPP4R1 USP34 PPP2R5B CLTCL1 CLTC NOC3L XPO1 TARBP1	3.46e-05	339	69	8	IPR016024
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	4.03e-05	3	69	2	IPR012331
Domain	CLH	CLTCL1 CLTC	4.03e-05	3	69	2	SM00299
Domain	Pyridoxal-P_BS	GAD1 DDC	1.34e-04	5	69	2	IPR021115
Domain	Musac_Ach_rcpt	CHRM1 CHRM5	1.34e-04	5	69	2	IPR000995
Domain	Clathrin	CLTCL1 CLTC	2.79e-04	7	69	2	PF00637
Domain	CHCR	CLTCL1 CLTC	2.79e-04	7	69	2	PS50236
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	3.71e-04	8	69	2	IPR000547
Domain	Pyridoxal_deC	GAD1 DDC	3.71e-04	8	69	2	PF00282
Domain	DDC_GAD_HDC_YDC	GAD1 DDC	3.71e-04	8	69	2	PS00392
Domain	PyrdxlP-dep_de-COase	GAD1 DDC	3.71e-04	8	69	2	IPR002129
Domain	E3_UB_ligase_RBR	RNF144B ANKIB1	5.94e-04	10	69	2	IPR031127
Domain	IBR	RNF144B ANKIB1	1.19e-03	14	69	2	SM00647
Domain	ATPase_dyneun-rel_AAA	DNAH12 MDN1	1.19e-03	14	69	2	IPR011704
Domain	IBR	RNF144B ANKIB1	1.19e-03	14	69	2	PF01485
Domain	AAA_5	DNAH12 MDN1	1.19e-03	14	69	2	PF07728
Domain	IBR_dom	RNF144B ANKIB1	1.37e-03	15	69	2	IPR002867
Domain	-	CLTCL1 CLTC CFAP70 CFAP46	7.23e-03	207	69	4	1.25.40.10
Domain	-	GAD1 DDC	7.40e-03	35	69	2	3.90.1150.10
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM5	1.18e-04	5	49	2	M27300
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM5	1.18e-04	5	49	2	MM15006
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	4.23e-06	2	72	2	20065094
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	4.23e-06	2	72	2	8733129
Pubmed	Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM5	4.23e-06	2	72	2	17586055
Pubmed	The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists.	CHRM1 CHRM5	4.23e-06	2	72	2	16877267
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	4.23e-06	2	72	2	29097553
Pubmed	Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors.	CHRM1 CHRM5	4.23e-06	2	72	2	17286988
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GAD1 GRIA4 CHRM1 DDC CHRM5	4.82e-06	118	72	5	19156168
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	1.27e-05	3	72	2	19509056
Pubmed	Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.	CHRM1 CHRM5	1.27e-05	3	72	2	1905013
Pubmed	Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2).	GAD1 DDC	1.27e-05	3	72	2	8499653
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	1.27e-05	3	72	2	15133132
Pubmed	Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.	CHRM1 CHRM5	1.27e-05	3	72	2	16956767
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	1.27e-05	3	72	2	22891263
Pubmed	M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.	CHRM1 CHRM5	1.27e-05	3	72	2	19657040
Pubmed	Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.	CHRM1 CHRM5	1.27e-05	3	72	2	23649821
Pubmed	M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.	CHRM1 CHRM5	1.27e-05	3	72	2	15146045
Pubmed	Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice.	CHRM1 CHRM5	1.27e-05	3	72	2	15691866
Pubmed	Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.	CHRM1 CHRM5	1.27e-05	3	72	2	21335473
Pubmed	Ciliary activity in the oviduct of cycling, pregnant, and muscarinic receptor knockout mice.	CHRM1 CHRM5	2.53e-05	4	72	2	22302687
Pubmed	Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.	CHRM1 CHRM5	2.53e-05	4	72	2	8063729
Pubmed	Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes.	CHRM1 CHRM5	2.53e-05	4	72	2	11855742
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	2.53e-05	4	72	2	11517213
Pubmed	Defining the membrane proteome of NK cells.	KSR1 CLTCL1 MDN1 AGO4 ALDH16A1 MPDU1 CLTC GEMIN5 XPO1 PEX11B TMBIM6	2.71e-05	1168	72	11	19946888
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	USP34 ZNF473 MPDU1 CLTC NOC3L GEMIN5 XPO1 TNFRSF10B PEX11B INTS3 ZFPL1	3.54e-05	1203	72	11	29180619
Pubmed	Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.	CHRM1 CHRM5	4.21e-05	5	72	2	24695732
Pubmed	Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.	CHRM1 CHRM5	4.21e-05	5	72	2	20940295
Pubmed	Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography.	CHRM1 CHRM5	4.21e-05	5	72	2	7648406
Pubmed	Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.	CHRM1 CHRM5	4.21e-05	5	72	2	26084221
Pubmed	Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.	CHRM1 CHRM5	4.21e-05	5	72	2	15574798
Pubmed	Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice.	CHRM1 CHRM5	4.21e-05	5	72	2	15919709
Pubmed	Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.	CHRM1 CHRM5	4.21e-05	5	72	2	12675128
Pubmed	Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.	CHRM1 CHRM5	4.21e-05	5	72	2	15913791
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	4.21e-05	5	72	2	10436022
Pubmed	Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.	CHRM1 CHRM5	4.21e-05	5	72	2	11306684
Pubmed	Muscarinic acetylcholine receptor subtypes: localization and structure/function.	CHRM1 CHRM5	4.21e-05	5	72	2	8248499
Pubmed	The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.	CHRM1 CHRM5	4.21e-05	5	72	2	30914695
Pubmed	Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.	CHRM1 CHRM5	4.21e-05	5	72	2	12151512
Pubmed	Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.	CHRM1 CHRM5	4.21e-05	5	72	2	29401598
Pubmed	Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM5	4.21e-05	5	72	2	15661360
Pubmed	Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.	CHRM1 CHRM5	4.21e-05	5	72	2	19213795
Pubmed	The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse.	CHRM1 CHRM5	4.21e-05	5	72	2	18755247
Pubmed	Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.	CHRM1 CHRM5	4.21e-05	5	72	2	20463237
Pubmed	Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.	CHRM1 CHRM5	4.21e-05	5	72	2	19940190
Pubmed	Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.	CHRM1 CHRM5	6.31e-05	6	72	2	31914675
Pubmed	The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.	CHRM1 CHRM5	6.31e-05	6	72	2	19182865
Pubmed	Expression of GAD67 and Dlx5 in the taste buds of mice genetically lacking Mash1.	GAD1 DDC	6.31e-05	6	72	2	24682237
Pubmed	Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.	LIMK1 CDC42BPB	6.31e-05	6	72	2	25107909
Pubmed	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.	CLTCL1 CLTC	8.82e-05	7	72	2	19478182
Pubmed	Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.	CLTC XPO1	8.82e-05	7	72	2	16314522
Pubmed	A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development.	CHRM1 CHRM5	8.82e-05	7	72	2	35427599
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TMCO4 KSR1 WDR6 SEC23IP VPS51 CDC42BPB TARBP1 ZFPL1	1.20e-04	719	72	8	35337019
Pubmed	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.	RNF144B GAD1 LIMK1 WDR6 GRIA4 MYO16	1.31e-04	376	72	6	24154525
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SEC23IP CLTC NOC3L XPO1 PEX11B VPS51 TARBP1 ZFPL1 HELLS	1.40e-04	942	72	9	31073040
Pubmed	Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets.	GRIA4 CHRM1	1.51e-04	9	72	2	24292102
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	GAD1 CHRM1 DDC CHRM5	1.57e-04	130	72	4	19874574
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	CLTCL1 CLTC	1.88e-04	10	72	2	25898166
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRM1 CHRM5	1.88e-04	10	72	2	10336173
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 CLTC	2.30e-04	11	72	2	29604273
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	MDN1 CLTC XPO1 INTS3 HELLS	2.57e-04	272	72	5	31010829
Pubmed	Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.	LIMK1 GRIA4	2.75e-04	12	72	2	26969129
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GAD1 GRIA4	3.25e-04	13	72	2	20859245
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ZDHHC21 USP34 MDN1 SEC23IP UGCG ANKIB1 LRRN2 TNFRSF10B ZFPL1	3.36e-04	1061	72	9	33845483
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	DNAH12 MDN1 MPDU1 SEC23IP INTS3 TARBP1 HELLS	3.55e-04	638	72	7	31182584
Pubmed	The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.	CLTC MUC2	3.78e-04	14	72	2	29361518
Pubmed	Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation.	MPDU1 ZFPL1	3.78e-04	14	72	2	34995116
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	GAD1 GRIA4 CHRM1 DDC CHRM5	4.03e-04	300	72	5	19086053
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 MDN1 WDR6 CLTC NOC3L GEMIN5 XPO1	4.08e-04	653	72	7	22586326
Pubmed	A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia.	DDC CHRM5	4.36e-04	15	72	2	19944766
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	MLH3 MDN1	4.36e-04	15	72	2	19762545
Pubmed	Identification of potential protein interactors of Lrrk2.	MDN1 CLTC	4.36e-04	15	72	2	17400507
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	MDN1 WDR6 MPDU1 SEC23IP CLTC XPO1	5.06e-04	484	72	6	31995728
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	CHRM1 CHRM5	5.63e-04	17	72	2	10549128
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	MDN1 CLTC GEMIN5 XPO1 INTS3	6.38e-04	332	72	5	32786267
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM1 CHRM5	7.06e-04	19	72	2	17373692
Pubmed	Genes, plasticity and mental retardation.	LIMK1 AFF2	7.06e-04	19	72	2	18329113
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 LIFR CLTCL1 MDN1 WDR6 CLTC NOC3L GEMIN5 XPO1 HELLS	7.44e-04	1440	72	10	30833792
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	MDN1 WDR6 CLTC XPO1	7.60e-04	197	72	4	31620119
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CLTC GEMIN5 XPO1 CDC42BPB	8.35e-04	202	72	4	33005030
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	CLTCL1 CLTC GEMIN5 CDC42BPB	8.35e-04	202	72	4	24639526
Pubmed	Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1.	GAD1 DDC	8.65e-04	21	72	2	19692620
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	CHRM1 CHRM5	8.65e-04	21	72	2	15452121
Pubmed	The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.	HGFAC MUC2	1.04e-03	23	72	2	19549527
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	WDR6 ALDH16A1 SEC23IP CLTC XPO1 VPS51	1.08e-03	560	72	6	35241646
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 AFF2 SEC23IP CLTC NOC3L CDC42BPB HELLS	1.13e-03	777	72	7	35844135
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PPP2R5B CLTCL1 WDR6 XPO1 INTS3 CDC42BPB	1.21e-03	573	72	6	28330616
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PPP4R1 USP34 LIMK1 ZNF473 SEC23IP CLTC LRRN2 CDC42BPB TARBP1	1.31e-03	1285	72	9	35914814
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	CLTCL1 CLTC	1.33e-03	26	72	2	24067654
Pubmed	Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1.	GAD1 DDC	1.43e-03	27	72	2	20080794
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	WDR6 SEC23IP TNFRSF10B TMBIM6	1.46e-03	235	72	4	32614325
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	MDN1 WDR6 GEMIN5 XPO1	1.50e-03	237	72	4	29564676
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	CLTC XPO1	1.54e-03	28	72	2	29653964
Pubmed	Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.	GAD1 DDC	1.54e-03	28	72	2	34564702
Pubmed	Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.	CLTCL1 CLTC	1.77e-03	30	72	2	22963397
Pubmed	Molecular design of hypothalamus development.	GAD1 DDC	1.89e-03	31	72	2	32499648
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	WDR6 CLTC XPO1	2.01e-03	120	72	3	37929963
Cytoband	11q13	VPS51 CHRM1 ZFPL1	8.67e-04	118	72	3	11q13
Cytoband	2p15	USP34 XPO1	1.10e-03	31	72	2	2p15
GeneFamily	Cholinergic receptors muscarinic	CHRM1 CHRM5	7.76e-05	5	51	2	180
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GAD1 AFF2 LRRC38 ADAMTS2 MYO16	4.36e-06	149	72	5	6e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLTCL1 MDN1 NOXRED1 LRRN2 TARBP1	5.12e-06	154	72	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KSR1 DNAH12 CFAP70 ZNF653 CCDC148	8.04e-06	169	72	5	8bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AFF2 ADAMTS2 LRRN2 MYO16 HELLS	8.04e-06	169	72	5	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	9.79e-06	176	72	5	682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.03e-05	178	72	5	6ad46b0720298bcb927fd53468bb4ea0c199ad35
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.06e-05	179	72	5	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.09e-05	180	72	5	8f774dcacc1626e4e6492f1eb927b0ed56fbe686
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.12e-05	181	72	5	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MUC2 MYO16	1.15e-05	182	72	5	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.28e-05	186	72	5	948815663c212c4311329d503b5991cbbbff9808
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.28e-05	186	72	5	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.31e-05	187	72	5	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.35e-05	188	72	5	72cbfe9dc0583dbeafa6cb0945fa370d0c808284
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.35e-05	188	72	5	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.38e-05	189	72	5	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.42e-05	190	72	5	3f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.49e-05	192	72	5	0003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38 MYO16	1.53e-05	193	72	5	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Papillary_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	CAPN14 CLTC MCF2 ST6GALNAC2	7.21e-05	137	72	4	2a5d2a99a2c532480d00b80a4885514a8a5c80fa
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Tshz2-Syt2_(Layer_5a,_Entorhinal_cortex,_Tshz1+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DNAH12 CSTL1 SLC44A3	7.74e-05	51	72	3	adc73d6909d75ad432aef884dae540b7e48cecd6
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	DNAH12 CFAP70 CFAP46 CCDC148	1.19e-04	156	72	4	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	AFF2 WDR6 CHRM5 CFAP46	1.22e-04	157	72	4	741d79c10cb87fa7f14080c6fccb1553c3a20bad
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH12 CFAP70 CFAP46 HELLS	1.22e-04	157	72	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGFAC DNAH12 GRIA4 DDC	1.48e-04	165	72	4	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	WDR6 CFAP70 CPLANE1 INTS3	1.51e-04	166	72	4	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 TMEM45A	1.58e-04	168	72	4	2eed7dc1a2aff11be024823c4323c42bc94362f6
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 CFAP70 CPLANE1 CFAP46	1.62e-04	169	72	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 CFAP70 CFAP46 CCDC148	1.62e-04	169	72	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF473 VARS2 FDXACB1 HELLS	1.66e-04	170	72	4	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	11.5-Airway-Epithelial-Basal_cell\|Airway / Age, Tissue, Lineage and Cell class	SNTG2 MUC2 ST6GALNAC2 SLC44A3	1.73e-04	172	72	4	9d4d92e2d16dfc8a394f2641653bb97de20a2530
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KSR1 LIMK1 ZNF473 ZFPL1	1.77e-04	173	72	4	efb8072475000888efe088d00e870c56ffad4172
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC21 THG1L LRRN2 TARBP1	1.81e-04	174	72	4	a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC21 THG1L LRRN2 TARBP1	1.81e-04	174	72	4	7f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KSR1 LIMK1 ZNF473 ZFPL1	1.81e-04	174	72	4	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38	1.85e-04	175	72	4	9d797888edb39fd12fd9cfc698a42b7bed19a5b5
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZSWIM3 ZNF473 ZNF653 HELLS	1.85e-04	175	72	4	8958c5c30437d20a4abd70d7527990f7e2a68b93
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIMK1 MDN1 CHRM1 ZNF653	1.93e-04	177	72	4	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIMK1 MDN1 CHRM1 ZNF653	1.93e-04	177	72	4	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	1.93e-04	177	72	4	91706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCell	Ciliated_cells-A-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH12 CFAP70 CFAP46 CCDC148	1.98e-04	178	72	4	255473ee6df8a13079fb3bb61038162a40cb4c2c
ToppCell	RSV-Healthy-0\|RSV / Virus stimulation, Condition and Cluster	USP34 ZSWIM3 SEC23IP CPLANE1	2.06e-04	180	72	4	974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCell	RSV-Healthy-0\|Healthy / Virus stimulation, Condition and Cluster	USP34 ZSWIM3 SEC23IP CPLANE1	2.06e-04	180	72	4	703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.11e-04	181	72	4	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DNAH12 ZNF473 CFAP70 CFAP46	2.11e-04	181	72	4	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	DNAH12 CFAP70 CFAP46 CCDC148	2.15e-04	182	72	4	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.15e-04	182	72	4	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GAD1 AFF2 DDC CCDC148	2.15e-04	182	72	4	1923932a9c60e9ec33db69ded441210d1fb07bec
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	DNAH12 CFAP70 CFAP46 CCDC148	2.15e-04	182	72	4	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GAD1 AFF2 DDC CCDC148	2.15e-04	182	72	4	69ff652f74cc47fbe0bd665ab17c445c5b959dad
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.20e-04	183	72	4	121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.20e-04	183	72	4	d2074b13b4831ec18c81273d9a1ff673c3f6a16d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.20e-04	183	72	4	04d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.24e-04	184	72	4	2ba98708dfd7f1b2a661578a334684094ff453ad
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	DNAH12 CFAP70 CFAP46 CCDC148	2.29e-04	185	72	4	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.29e-04	185	72	4	f4ac62009c0ad3346e71b809e17727303c4df153
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	DNAH12 CFAP70 CFAP46 CCDC148	2.43e-04	188	72	4	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD1 GRIA4 ST6GALNAC2 MYO16	2.48e-04	189	72	4	222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.48e-04	189	72	4	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	DNAH12 CFAP70 CFAP46 CCDC148	2.48e-04	189	72	4	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	DNAH12 CFAP70 CFAP46 CCDC148	2.48e-04	189	72	4	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38	2.53e-04	190	72	4	26843ec1d19ac85a50990705353b802745d33e4d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.53e-04	190	72	4	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.53e-04	190	72	4	39ab890104b4264c68a968f920f4ccd84f0bc681
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.53e-04	190	72	4	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.53e-04	190	72	4	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.53e-04	190	72	4	e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH12 CFAP70 CFAP46 CCDC148	2.58e-04	191	72	4	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LIFR KSR1 ADAMTS2 MYO16	2.58e-04	191	72	4	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH12 CFAP70 CFAP46 CCDC148	2.58e-04	191	72	4	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.58e-04	191	72	4	782bc7946417549ffd39e5b596db659436fa01ba
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GAD1 AFF2 MYO16	2.58e-04	191	72	4	7b386512284dfaa0e95358b28ee82632ee965e64
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DNAH12 CFAP70 CFAP46 CCDC148	2.58e-04	191	72	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM45A ADAMTS2 GRIA4 LRRN2	2.64e-04	192	72	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GAD1 CLTCL1 AFF2 RAB44	2.64e-04	192	72	4	072281344d58e85c9a290750b488d0c101f75d54
ToppCell	LAM-Epithelial-AirwayEpi\|LAM / Condition, Lineage and Cell class	DNAH12 TMEM45A CFAP70 CFAP46	2.64e-04	192	72	4	7404fc65be3b7bd09447725b43fa31819004dfee
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM45A ADAMTS2 GRIA4 LRRN2	2.64e-04	192	72	4	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 LRRC38	2.64e-04	192	72	4	67d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM45A ADAMTS2 GRIA4 LRRN2	2.64e-04	192	72	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	mild-Myeloid-Immature_Neutrophils_2\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLTCL1 AFF2 UGCG RAB44	2.64e-04	192	72	4	0445fdc670fa7b847dcd0a061d7736ddcf3519ba
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	DNAH12 CFAP70 CFAP46 CCDC148	2.64e-04	192	72	4	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	control-Myeloid-Immature_Neutrophils_2\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLTCL1 AFF2 UGCG RAB44	2.69e-04	193	72	4	33349830e9eba506470ad3661fad5e5a283d20ca
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 LRRC38 MYO16	2.69e-04	193	72	4	4979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell	LAM-Epithelial-AirwayEpi\|Epithelial / Condition, Lineage and Cell class	DNAH12 TMEM45A CFAP70 CFAP46	2.69e-04	193	72	4	f2672d2c495ee12c3b7d132452bde581fa5a7856
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 MYO16	2.74e-04	194	72	4	4f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B GAD1 AFF2 MYO16	2.74e-04	194	72	4	02a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 CFAP70 CPLANE1 CFAP46	2.80e-04	195	72	4	79dc031258579ea328181dda33710dd897f1064a
ToppCell	18-Airway-Epithelial-Multiciliated_cell\|Airway / Age, Tissue, Lineage and Cell class	DNAH12 CFAP70 ST6GALNAC2 CFAP46	2.80e-04	195	72	4	3441381759cd00d125752401dc99b78be1c78f88
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 CFAP70 CPLANE1 CFAP46	2.91e-04	197	72	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	MDN1 UGCG SNTG2 TNFRSF10B	2.96e-04	198	72	4	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLTCL1 AFF2 UGCG RAB44	2.96e-04	198	72	4	844f534551483c89ef789d1cfeb4680e54f794b2
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLTCL1 AFF2 RAB44 HELLS	2.96e-04	198	72	4	e36303628af3139310c1d7a84d2919b7319bbda4
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	CLTCL1 ADAMTS2 MYO16 HELLS	3.02e-04	199	72	4	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RNF144B GAD1 LRRC38 MYO16	3.08e-04	200	72	4	e79d93d55b25804f2608185168da472301b6ebca
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RNF144B GAD1 LRRC38 MYO16	3.08e-04	200	72	4	3cbb01039d1e7635ec4dcdf0223587f7ea3c7b34
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RNF144B GAD1 LRRC38 MYO16	3.08e-04	200	72	4	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RNF144B GAD1 LRRC38 MYO16	3.08e-04	200	72	4	1276bfa911fddada4235e12e3081baa53164574b
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RNF144B GAD1 LRRC38 MYO16	3.08e-04	200	72	4	97a010a1b6d551239cf6ea5a43319fb413ff180e
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RNF144B GAD1 LRRC38 MYO16	3.08e-04	200	72	4	5ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCell	severe-immature_Neutrophil\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CLTCL1 AFF2 UGCG RAB44	3.08e-04	200	72	4	a9b87accdaa6956116ab82427e1330e8f007ef94
Drug	Badg	CLTCL1 CLTC	9.59e-06	2	71	2	CID000125951
Drug	PGW5 compound	GAD1 CHRM1 CHRM5	1.92e-05	17	71	3	ctd:C000593032
Drug	library 2	CLTCL1 CLTC MCF2	2.72e-05	19	71	3	CID005270634
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; PC3; HT_HG-U133A	LIMK1 PPP2R5B KLHDC3 SEC23IP NOC3L ZFPL1	3.30e-05	195	71	6	6643_DN
Drug	biperiden	CHRM1 DDC CHRM5	4.92e-05	23	71	3	CID000002381
Drug	hexocyclium	CHRM1 CHRM5	5.73e-05	4	71	2	CID000024199
Drug	AC1OAR8J	CLTCL1 CLTC	5.73e-05	4	71	2	CID006834124
Drug	Botiacrine	CHRM1 CHRM5	5.73e-05	4	71	2	CID000071202
Drug	fluperlapine	CHRM1 DDC CHRM5	8.06e-05	27	71	3	CID000049381
Drug	Atropine	CHRM1 CHRM5	9.53e-05	5	71	2	DB00572
Drug	Fesoterodine	CHRM1 CHRM5	9.53e-05	5	71	2	DB06702
Drug	Darifenacin	CHRM1 CHRM5	9.53e-05	5	71	2	DB00496
Drug	Metixene	CHRM1 CHRM5	9.53e-05	5	71	2	DB00340
Drug	Trihexyphenidyl	CHRM1 CHRM5	9.53e-05	5	71	2	DB00376
Drug	Solifenacin	CHRM1 CHRM5	9.53e-05	5	71	2	DB01591
Drug	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	CHRM1 CHRM5	9.53e-05	5	71	2	ctd:C568516
Drug	Pipecuronium	CHRM1 CHRM5	9.53e-05	5	71	2	ctd:D017300
Drug	N-Methylscopolamine	CHRM1 CHRM5	9.53e-05	5	71	2	ctd:D019832
Drug	F 2268	CHRM1 CHRM5	9.53e-05	5	71	2	CID000020410
Drug	eucatropine	CHRM1 CHRM5	9.53e-05	5	71	2	CID000007534
Drug	Tolterodine	CHRM1 CHRM5	9.53e-05	5	71	2	DB01036
Drug	[[2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)-2-isobutyl-1,4-dimethyl-pentyl]amino] benzoate	CHRM1 DDC	9.53e-05	5	71	2	CID011971451
Drug	Cryptenamine	CHRM1 CHRM5	9.53e-05	5	71	2	DB00785
Drug	Homatropine Methylbromide	CHRM1 CHRM5	9.53e-05	5	71	2	DB00725
Drug	hexahydro-difenidol	CHRM1 CHRM5	9.53e-05	5	71	2	CID000124226
Drug	Quinuclidinyl Benzilate	CHRM1 CHRM5	9.53e-05	5	71	2	ctd:D011813
Drug	trihexyphenidyl	CHRM1 DDC CHRM5	1.35e-04	32	71	3	CID000005572
Drug	Nsc34399	CHRM1 CHRM5	1.43e-04	6	71	2	CID000003622
Drug	Gallamine Triethiodide	CHRM1 CHRM5	1.43e-04	6	71	2	ctd:D005703
Drug	Dactil	CHRM1 CHRM5	1.43e-04	6	71	2	CID000004839
Drug	4-diphenylacetoxy-1,1-dimethylpiperidinium	CHRM1 CHRM5	1.43e-04	6	71	2	ctd:C042375
Drug	brucine N-oxide	CHRM1 CHRM5	1.43e-04	6	71	2	ctd:C083067
Drug	Brompheniramine	CHRM1 CHRM5	1.43e-04	6	71	2	DB00835
Drug	AC1L1IPS	CLTCL1 CLTC	1.43e-04	6	71	2	CID000004682
Drug	Benzquinamide	CHRM1 CHRM5	1.43e-04	6	71	2	DB00767
Drug	Scopolamine	CHRM1 CHRM5	1.43e-04	6	71	2	DB00747
Drug	Crotalid Venoms	CHRM1 CHRM5	1.43e-04	6	71	2	ctd:D003435
Disease	central nervous system disease (implicated_via_orthology)	GEMIN5 GRIA4	6.52e-04	16	70	2	DOID:331 (implicated_via_orthology)
Disease	Muscle hypotonia	NUDT2 DDC	7.37e-04	17	70	2	C0026827
Disease	antiphospholipid antibody measurement	ZNF653 MYO16	1.61e-03	25	70	2	EFO_0005200
Disease	bipolar disorder (is_implicated_in)	GAD1 DDC	2.16e-03	29	70	2	DOID:3312 (is_implicated_in)
Disease	sex interaction measurement, Crohn's disease	USP34 XPO1	3.50e-03	37	70	2	EFO_0000384, EFO_0008343
Disease	colon cancer (biomarker_via_orthology)	TNFRSF10B MUC2	3.88e-03	39	70	2	DOID:219 (biomarker_via_orthology)
Disease	Global developmental delay	RHOBTB2 NUDT2 DDC	3.93e-03	133	70	3	C0557874

Protein segments in the cluster

Peptide	Gene	Start	Entry
WNNEYILSLIEDNCH	PPP2R5B	381	Q15173
NCQLSEEDHWIYQAI	CCDC148	256	Q8NFR7
AWLDTQDRCLGHYVN	ALDH16A1	31	Q8IZ83
FFRDWDLEQQCHYEQ	AFF2	6	P51816
DCCLAAYAFFRHIWQ	CFAP46	1321	Q8IYW2
EAYEDAANCLWLLTN	ANKIB1	501	Q9P2G1
HYQVLWDDNCFTADE	AGO4	766	Q9HCK5
HQAYRWLGLEEACQL	NUDT2	111	P50583
CNKEDIWLHVDAAYA	DDC	261	P20711
QCRQWDLYFEHGDAQ	ADAMTS2	626	O95450
CWFLAALQALALHQD	CAPN14	101	A8MX76
FAHVRYWLDCLQDAG	RAB44	921	Q7Z6P3
FEQYCAWQLFLAHNI	INTS3	806	Q68E01
HTFCWYCLQNLDNDI	RNF144B	216	Q7Z419
NALQHCYWKYLIVDE	HELLS	341	Q9NRZ9
IHQQLCLNFARSLWY	MDN1	3626	Q9NU22
FLKYWHADQLNDLCL	MYO16	1131	Q9Y6X6
TEYWACLQVAFADAH	LRRN2	591	O75325
DICEKYNLWLHVDAA	GAD1	361	Q99259
ALLSLLDHYEWNCFV	GRIA4	141	P48058
ENQLKLSHDWLCYLA	KSR1	766	Q8IVT5
WCYHKNLEDLGLEFV	MLH3	1276	Q9UHC1
LNIESANYAEHWCSL	MUC2	576	Q02817
YFQLWNNSCLEAEHV	CSTL1	126	Q9H114
IELLRQFFDCGHWYD	DNAH12	1976	Q6ZR08
DCDFAHLFSWIQENA	LRRC38	191	Q5VT99
GDCQWITALHYAFQD	CDC42BPB	131	Q9Y5S2
SCLAWNSDLLYQELH	HGFAC	306	Q04756
EEDTNLWIGYCAFHL	TTC26	56	A0AVF1
IFQLFHQCLSIHYWD	CPLANE1	636	Q9H799
HWLDYGAFCLLTEDN	CFAP70	671	Q5T0N1
LACDLWLALDYVASN	CHRM1	96	P11229
CHCLAWFIFDYIQLR	UGCG	321	Q16739
QDYIWHCIDLFLDFI	TMBIM6	201	P55061
YCHSEWIIFRNAIEN	MCF2	86	P10911
ACNVLYAFDVNTHKW	KLHDC3	101	Q9BQ90
CFWCLDKYLLHLNQN	SLC44A3	481	Q8N4M1
NCDFLSAAFWISLHE	FDXACB1	281	Q9BRP7
LNRALYFACDNVLWA	PEX11B	91	O96011
QLENFAAFILDHRCW	SLC22A25	36	Q6T423
RCYIDNLHFSGLEEW	LIFR	221	P42702
EYCNAQNTALWELHA	NOC3L	681	Q8WTT2
CFYHNADLVSWADVI	NOXRED1	126	Q6NXP6
HFWLHNLCDVYLEAV	VARS2	811	Q5ST30
ALLDQELYNSFHFWR	PPP4R1	446	Q8TF05
ALAHSREQYCLAWEA	TMCO4	301	Q5TGY1
LELAQFHCAYQLADW	RHOBTB2	616	Q9BYZ6
IFYANHDLSLEAALW	ST6GALNAC2	346	Q9UJ37
CWLQANLYLGLQDFD	SNTG2	366	Q9NY99
NEYLFALQSHLCYWE	SEC23IP	961	Q9Y6Y8
KCYDQLFVQWDLLHV	MPDU1	21	O75352
LACDLWLALDYVASN	CHRM5	101	P08912
AAEQAHLWAELVFLY	CLTC	1351	Q00610
AAEQAHLWAELVFLY	CLTCL1	1351	P53675
LVKEALSWYDAQQHC	CLEC20A	26	Q6ZU45
DCHFLQLYLWRFVAD	VPS51	731	Q9UID3
FKICLEYWNHLAAEL	XPO1	366	O14980
AVWQCEAGHRYFQDL	ZNF653	156	Q96CK0
DLQNLIDFAQEYWSC	TSPAN17	141	Q96FV3
DYLSWRQADCHINNL	THG1L	171	Q9NWX6
CFEDHLEQKYVQLFW	SPATA31D1	491	Q6ZQQ2
CYWFNRNDSQHLFIE	GEMIN5	136	Q8TEQ6
QDYSTHWNDLLFCLR	TNFRSF10B	101	O14763
WEQLLEDKHFQSYCL	WDR6	381	Q9NNW5
NHWLFLQLCFYTELL	ZDHHC21	131	Q8IVQ6
DLFNFLQAHWFTCEL	ZSWIM3	361	Q96MP5
AQYIHDQWVCLSFLL	TARBP1	886	Q13395
DSECYDDALHWFLNQ	USP34	1021	Q70CQ2
ENILFLTICFCWHYA	TMEM45A	216	Q9NWC5
QHVSRNFNLWACDYV	TEX36	101	Q5VZQ5
YDLFHWACLNERAAQ	ZFPL1	71	O95159
FWDTALDNCQDLFLL	ZNF473	31	Q8WTR7
QYLQALNADWHADCF	LIMK1	36	P53667