Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.08e-10	11	70	5	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.94e-10	14	70	5	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.92e-09	21	70	5	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.83e-07	37	70	5	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.10e-07	38	70	5	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	5.61e-07	46	70	5	GO:0016893
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 RBBP4 ERVK-8 MUS81 ERVK-7 ERVK-10 PLD3 ERVK-11	3.69e-06	262	70	8	GO:0140097
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 MUS81 ERVK-7 ERVK-10 ERVK-11	8.19e-06	136	70	6	GO:0004519
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	8.38e-06	37	70	4	GO:0004190
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.44e-06	79	70	5	GO:0004521
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	9.34e-06	38	70	4	GO:0070001
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ERVK-8 MUS81 ERVK-7 ERVK-10 PLD3 ERVK-11	1.63e-05	231	70	7	GO:0004518
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2 ITPR3	3.24e-05	18	70	3	GO:0015278
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	7.24e-05	4	70	2	GO:0005219
GeneOntologyMolecularFunction	metalloaminopeptidase activity	RNPEP NPEPPS RNPEPL1	1.01e-04	26	70	3	GO:0070006
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.16e-04	136	70	5	GO:0004540
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR2 ITPR3	1.73e-04	31	70	3	GO:0099604
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	1.80e-04	6	70	2	GO:0048763
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.94e-04	152	70	5	GO:0016779
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR2 ITPR3	2.09e-04	33	70	3	GO:0005217
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 RNPEP NPEPPS RNPEPL1 ERVK-8 KLK12 ERVK-7 ERVK-10 MASP2	4.49e-04	654	70	9	GO:0008233
GeneOntologyMolecularFunction	aminopeptidase activity	RNPEP NPEPPS RNPEPL1	4.60e-04	43	70	3	GO:0004177
GeneOntologyMolecularFunction	guanylate cyclase activity	NPR2 GUCY2F	5.35e-04	10	70	2	GO:0004383
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 UBR2 RNPEP NPEPPS RNPEPL1 ERVK-8 MIB2 ERVK-7 ERVK-10 ERVK-11	1.04e-03	891	70	10	GO:0008270
GeneOntologyMolecularFunction	calcium ion binding	FAT2 DUOX2 ADGRV1 CUBN RYR1 RYR2 ADGRL4 MASP2 ITPR3	1.18e-03	749	70	9	GO:0005509
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 NPR2 GUCY2F ERVK-8 ERVK-7 ERVK-10 ERVK-11 STK31 ADPGK MAST3	1.53e-03	938	70	10	GO:0016772
GeneOntologyMolecularFunction	adenylate cyclase activity	NPR2 GUCY2F	1.79e-03	18	70	2	GO:0004016
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 RBBP4 ERVK-8 MUS81 ERVK-7 ERVK-10 PLD3 ERVK-11	1.84e-03	645	70	8	GO:0140640
GeneOntologyMolecularFunction	metalloexopeptidase activity	RNPEP NPEPPS RNPEPL1	1.91e-03	70	70	3	GO:0008235
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 UBR2 RNPEP HPD NPEPPS RNPEPL1 ERVK-8 MIB2 ERVK-7 ERVK-10 ERVK-11	2.70e-03	1189	70	11	GO:0046914
GeneOntologyMolecularFunction	cyclase activity	NPR2 GUCY2F	3.18e-03	24	70	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	NPR2 GUCY2F	3.45e-03	25	70	2	GO:0016849
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-8 KLK12 ERVK-7 ERVK-10 MASP2	3.95e-03	430	70	6	GO:0004175
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	4.91e-10	13	70	5	GO:0015074
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	5.95e-07	48	70	5	GO:0000731
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	9.21e-06	83	70	5	GO:0006278
GeneOntologyBiologicalProcess	DNA replication	ERVK-6 RBBP4 RBBP7 ERVK-8 MUS81 ERVK-7 ERVK-10 ERVK-11	1.05e-05	312	70	8	GO:0006260
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 ERVK-8 MUS81 ERVK-7 ERVK-10 ERVK-11	3.15e-05	178	70	6	GO:0006261
GeneOntologyCellularComponent	NURF complex	RBBP4 RBBP7	2.30e-04	7	70	2	GO:0016589
GeneOntologyCellularComponent	nuclear outer membrane	GUCY2F SYNE1 ITPR3	3.25e-04	40	70	3	GO:0005640
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	4.89e-04	10	70	2	GO:0014701
GeneOntologyCellularComponent	cluster of actin-based cell projections	ESPNL ANKRD24 ADGRV1 CUBN ITPR3	9.10e-04	223	70	5	GO:0098862
GeneOntologyCellularComponent	ISWI-type complex	RBBP4 RBBP7	9.80e-04	14	70	2	GO:0031010
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	SLC30A5 HPD GUCY2F SYNE1 CKAP4 PLD3 ADPGK RYR1 RYR2 RETREG3 ITPR3 DUOXA2	1.40e-03	1327	70	12	GO:0042175
GeneOntologyCellularComponent	CHD-type complex	RBBP4 RBBP7	1.46e-03	17	70	2	GO:0090545
GeneOntologyCellularComponent	ESC/E(Z) complex	RBBP4 RBBP7	1.46e-03	17	70	2	GO:0035098
GeneOntologyCellularComponent	NuRD complex	RBBP4 RBBP7	1.46e-03	17	70	2	GO:0016581
GeneOntologyCellularComponent	stereocilium	ESPNL ANKRD24 ADGRV1	1.61e-03	69	70	3	GO:0032420
GeneOntologyCellularComponent	stereocilium bundle	ESPNL ANKRD24 ADGRV1	2.37e-03	79	70	3	GO:0032421
GeneOntologyCellularComponent	Sin3-type complex	RBBP4 RBBP7	2.45e-03	22	70	2	GO:0070822
Domain	RIH_assoc	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	IPR013662
Domain	RIH_dom	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	IPR015925
Domain	-	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2 ITPR3	7.99e-07	6	65	3	PF08709
Domain	MIR	RYR1 RYR2 ITPR3	4.74e-06	10	65	3	PS50919
Domain	MIR	RYR1 RYR2 ITPR3	4.74e-06	10	65	3	PF02815
Domain	MIR	RYR1 RYR2 ITPR3	4.74e-06	10	65	3	SM00472
Domain	MIR_motif	RYR1 RYR2 ITPR3	4.74e-06	10	65	3	IPR016093
Domain	Peptidase_M1	RNPEP NPEPPS RNPEPL1	8.65e-06	12	65	3	IPR001930
Domain	Peptidase_M1	RNPEP NPEPPS RNPEPL1	1.12e-05	13	65	3	PF01433
Domain	Peptidase_M1_N	RNPEP NPEPPS RNPEPL1	1.12e-05	13	65	3	IPR014782
Domain	Ryanrecept_TM4-6	RYR1 RYR2	3.57e-05	3	65	2	IPR009460
Domain	RyR	RYR1 RYR2	3.57e-05	3	65	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	3.57e-05	3	65	2	IPR003032
Domain	CAF1C_H4-bd	RBBP4 RBBP7	3.57e-05	3	65	2	PF12265
Domain	RR_TM4-6	RYR1 RYR2	3.57e-05	3	65	2	PF06459
Domain	Histone-bd_RBBP4_N	RBBP4 RBBP7	3.57e-05	3	65	2	IPR022052
Domain	Ryan_recept	RYR1 RYR2	3.57e-05	3	65	2	IPR013333
Domain	Leuk-A4-hydro_C	RNPEP RNPEPL1	7.12e-05	4	65	2	PF09127
Domain	Peptidase_M1_C	RNPEP RNPEPL1	7.12e-05	4	65	2	IPR015211
Domain	Leuk-A4-hydro_C	RNPEP RNPEPL1	7.12e-05	4	65	2	SM01263
Domain	EGF_CA	FAT2 CUBN ADGRL4 MASP2	8.63e-04	122	65	4	SM00179
Domain	EGF-like_Ca-bd_dom	FAT2 CUBN ADGRL4 MASP2	9.17e-04	124	65	4	IPR001881
Domain	A/G_cyclase_CS	NPR2 GUCY2F	1.57e-03	17	65	2	IPR018297
Domain	Nucleotide_cyclase	NPR2 GUCY2F	1.76e-03	18	65	2	IPR029787
Domain	-	NPR2 GUCY2F	1.76e-03	18	65	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	NPR2 GUCY2F	1.96e-03	19	65	2	PS00452
Domain	Guanylate_cyc	NPR2 GUCY2F	1.96e-03	19	65	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR2 GUCY2F	1.96e-03	19	65	2	PS50125
Domain	A/G_cyclase	NPR2 GUCY2F	1.96e-03	19	65	2	IPR001054
Domain	CYCc	NPR2 GUCY2F	1.96e-03	19	65	2	SM00044
Domain	MHC_I	CD1A MICA	2.40e-03	21	65	2	PF00129
Domain	MHC_I_a_a1/a2	CD1A MICA	2.40e-03	21	65	2	IPR001039
Domain	-	CD1A MICA	3.13e-03	24	65	2	3.30.500.10
Domain	MHC_I-like_Ag-recog	CD1A MICA	3.13e-03	24	65	2	IPR011161
Domain	EGF_CA	CUBN ADGRL4 MASP2	3.35e-03	86	65	3	PF07645
Domain	EGF_Ca-bd_CS	CUBN ADGRL4 MASP2	4.70e-03	97	65	3	IPR018097
Domain	ZINC_PROTEASE	RNPEP NPEPPS RNPEPL1	4.84e-03	98	65	3	PS00142
Domain	EGF_CA	CUBN ADGRL4 MASP2	4.97e-03	99	65	3	PS01187
Domain	ASX_HYDROXYL	CUBN ADGRL4 MASP2	5.12e-03	100	65	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CUBN ADGRL4 MASP2	6.01e-03	106	65	3	IPR000152
Domain	-	RBBP4 RBBP7 WDR59 PLXNA1 DMXL1	6.03e-03	333	65	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	RBBP4 RBBP7 WDR59 PLXNA1 DMXL1	6.18e-03	335	65	5	IPR015943
Domain	GPS	ADGRV1 ADGRL4	6.23e-03	34	65	2	SM00303
Domain	EF-hand_8	RYR1 RYR2	6.23e-03	34	65	2	PF13833
Domain	GPS	ADGRV1 ADGRL4	6.59e-03	35	65	2	PF01825
Domain	Ank_2	ESPNL ANKRD30B ANKRD24 MIB2	6.68e-03	215	65	4	PF12796
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR2 ITPR3	3.91e-05	19	50	3	M47760
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	3.40e-08	4	72	3	10469592
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2 ITPR3	1.69e-07	6	72	3	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2 ITPR3	1.69e-07	6	72	3	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2 ITPR3	1.69e-07	6	72	3	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2 ITPR3	1.69e-07	6	72	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2 ITPR3	2.96e-07	7	72	3	11860456
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2 ITPR3	4.73e-07	8	72	3	19033399
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.57e-06	94	72	5	21542922
Pubmed	DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.	DUOX2 DUOXA2	4.23e-06	2	72	2	24492313
Pubmed	DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.	DUOX2 DUOXA2	4.23e-06	2	72	2	32425884
Pubmed	Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.	DUOX2 DUOXA2	4.23e-06	2	72	2	28541007
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	4.23e-06	2	72	2	17259277
Pubmed	Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia.	DUOX2 DUOXA2	4.23e-06	2	72	2	22592922
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	4.23e-06	2	72	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	4.23e-06	2	72	2	26009179
Pubmed	When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.	DUOX2 DUOXA2	4.23e-06	2	72	2	25761904
Pubmed	Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes.	RBBP4 RBBP7	4.23e-06	2	72	2	12376095
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	4.23e-06	2	72	2	32899693
Pubmed	Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.	RYR2 ITPR3	4.23e-06	2	72	2	24285081
Pubmed	Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.	DUOX2 DUOXA2	4.23e-06	2	72	2	27349010
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	4.23e-06	2	72	2	30542613
Pubmed	Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.	RYR2 ITPR3	4.23e-06	2	72	2	18586264
Pubmed	The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.	DUOX2 DUOXA2	4.23e-06	2	72	2	31513783
Pubmed	Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).	RBBP4 RBBP7	4.23e-06	2	72	2	38577935
Pubmed	DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom.	DUOX2 DUOXA2	4.23e-06	2	72	2	31044655
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	4.23e-06	2	72	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	4.23e-06	2	72	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	4.23e-06	2	72	2	11673462
Pubmed	Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development.	RBBP4 RBBP7	4.23e-06	2	72	2	34709113
Pubmed	Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.	RYR1 ITPR3	4.23e-06	2	72	2	21150295
Pubmed	Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.	DUOX2 DUOXA2	4.23e-06	2	72	2	17374849
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	4.23e-06	2	72	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	4.23e-06	2	72	2	15033925
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	4.23e-06	2	72	2	18618700
Pubmed	The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression.	RBBP4 RBBP7	1.27e-05	3	72	2	18577416
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.27e-05	3	72	2	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.27e-05	3	72	2	18434746
Pubmed	Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.	DUOX2 DUOXA2	1.27e-05	3	72	2	23010498
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.27e-05	3	72	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.27e-05	3	72	2	7876312
Pubmed	Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast.	RBBP4 RBBP7	1.27e-05	3	72	2	7503932
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.27e-05	3	72	2	21881589
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.27e-05	3	72	2	24123915
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-11	1.27e-05	3	72	2	9971820
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.27e-05	3	72	2	12213830
Pubmed	Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.	RNPEP NPEPPS	1.27e-05	3	72	2	26078706
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.27e-05	3	72	2	23278119
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	1.27e-05	3	72	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	1.27e-05	3	72	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.27e-05	3	72	2	23454728
Pubmed	Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.	DUOX2 DUOXA2	1.27e-05	3	72	2	16651268
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	1.27e-05	3	72	2	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	1.27e-05	3	72	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	1.27e-05	3	72	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	1.27e-05	3	72	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	1.27e-05	3	72	2	11159936
Pubmed	Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines.	DUOX2 DUOXA2	1.27e-05	3	72	2	21321110
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	1.27e-05	3	72	2	9986730
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	1.27e-05	3	72	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	1.27e-05	3	72	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	1.27e-05	3	72	2	4600883
Pubmed	The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7.	RBBP4 RBBP7	1.27e-05	3	72	2	27144666
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	1.27e-05	3	72	2	7635066
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIP1 FANCI RNPEPL1 MUS81 MIB2 WDR59 PLXNA1 RYR1 GAREM1 ITPR3 SLC52A3	1.63e-05	1105	72	11	35748872
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 ITPR3	2.53e-05	4	72	2	22100703
Pubmed	Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers.	CPT2 RYR1	2.53e-05	4	72	2	20952238
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	2.53e-05	4	72	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	2.53e-05	4	72	2	22504960
Pubmed	Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.	FANCI MUS81	2.53e-05	4	72	2	25319828
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	2.53e-05	4	72	2	23992453
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	2.53e-05	4	72	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	2.53e-05	4	72	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	2.53e-05	4	72	2	9607712
Pubmed	Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB.	RBBP4 RBBP7	2.53e-05	4	72	2	10866654
Pubmed	Isolation of human NURF: a regulator of Engrailed gene expression.	RBBP4 RBBP7	2.53e-05	4	72	2	14609955
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	2.53e-05	4	72	2	27226555
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10	2.53e-05	4	72	2	7983737
Pubmed	The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.	DUOX2 DUOXA2	2.53e-05	4	72	2	22814254
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	2.53e-05	4	72	2	19120137
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	2.53e-05	4	72	2	11237759
Pubmed	Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.	DUOX2 DUOXA2	2.53e-05	4	72	2	19339556
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	2.53e-05	4	72	2	23482488
Pubmed	Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells.	RBBP4 RBBP7	2.53e-05	4	72	2	24727455
Pubmed	Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.	RBBP4 RBBP7	4.21e-05	5	72	2	29158494
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7	4.21e-05	5	72	2	12629516
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	4.21e-05	5	72	2	11401426
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	4.21e-05	5	72	2	22939628
Pubmed	MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.	RBBP4 RBBP7	4.21e-05	5	72	2	10471499
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	4.21e-05	5	72	2	9124414
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	4.21e-05	5	72	2	23918386
Pubmed	Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.	DUOX2 DUOXA2	4.21e-05	5	72	2	33127391
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	4.21e-05	5	72	2	19011160
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FRRS1 RBBP7 SLCO2B1 FANCI PHTF2 PLD3 CPT2 ADPGK RETREG3 DUOXA2 SLC52A3	4.73e-05	1242	72	11	30973865
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	6.31e-05	6	72	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	6.31e-05	6	72	2	26025922
Pubmed	SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex.	RBBP4 RBBP7	6.31e-05	6	72	2	16738318
Pubmed	Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.	RBBP4 RBBP7	6.31e-05	6	72	2	9427644
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	6.31e-05	6	72	2	14592808
Pubmed	CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.	RBBP4 RBBP7	6.31e-05	6	72	2	25795299
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	6.31e-05	6	72	2	19009018
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	2.24e-05	3	50	2	287
GeneFamily	Lysine methyltransferases\|Myb/SANT domain containing\|Polycomb repressive complex 2	RBBP4 RBBP7	1.12e-04	6	50	2	1347
GeneFamily	Guanylate cyclase receptors	NPR2 GUCY2F	1.56e-04	7	50	2	343
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	RBBP4 RBBP7	2.67e-04	9	50	2	1306
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	RBBP4 RBBP7	4.86e-04	12	50	2	1243
GeneFamily	PHD finger proteins\|NuRD complex	RBBP4 RBBP7	4.86e-04	12	50	2	1305
GeneFamily	Aminopeptidases\|CD molecules	RNPEP NPEPPS	9.93e-04	17	50	2	104
GeneFamily	Neuroblastoma breakpoint family	NBPF19 NBPF15	1.83e-03	23	50	2	662
GeneFamily	Ankyrin repeat domain containing	ESPNL ANKRD30B ANKRD24 MIB2	4.45e-03	242	50	4	403
GeneFamily	Tudor domain containing	UHRF2 STK31	4.69e-03	37	50	2	780
GeneFamily	WD repeat domain containing	RBBP4 RBBP7 WDR59 DMXL1	5.89e-03	262	50	4	362
GeneFamily	C1-set domain containing	CD1A MICA	6.01e-03	42	50	2	591
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 HIP1 HPD CUBN DSCAML1 RYR2	3.18e-07	181	67	6	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	Int-URO-Lymphocyte-T_NK-gdT\|Int-URO / Disease, Lineage and Cell Type	KIAA1671 SYNE1 STK31 RYR2 SLC52A3	6.87e-06	176	67	5	15016a73c953d8d3e7c32a05ead5e7261f9914ca
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERAS ANKRD30B KLK12 CKAP4 DSCAML1	7.25e-06	178	67	5	9099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	KIAA1671 HIP1 SYNE1 SH2D3C ADGRL4	1.13e-05	195	67	5	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GFPT2 CUBN STK31 GAREM1	5.59e-05	138	67	4	611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT2 ERAS DUOXA2 SLC52A3	6.42e-05	143	67	4	28e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	NPR2 STK31 PLXNA1 RYR1	9.68e-05	159	67	4	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo\|Lung / Manually curated celltypes from each tissue	FANCI STAT4 MASP2 ITPR3	1.02e-04	161	67	4	a1f10e04836848b1deaf295fae033f54d1572fcd
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLCO2B1 SYNE1 AIPL1 PLD3	1.07e-04	163	67	4	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	CD1A FAT2 KLK12 FAM13B	1.07e-04	163	67	4	d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 SLCO2B1 PLD3 PLXNA1	1.25e-04	170	67	4	067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCell	normal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T\|normal_Pleural_Fluid / Location, Cell class and cell subclass	KIAA1671 SYNE1 MIB2 STAT4	1.28e-04	171	67	4	6be81c20f4e962b414afcedfe478dd59c510d1e1
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERAS ANKRD30B KLK12 CKAP4	1.40e-04	175	67	4	019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT2 SLCO2B1 ANKRD24 ADGRL4	1.43e-04	176	67	4	27e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA1671 HIP1 GPR45 ADGRL4	1.43e-04	176	67	4	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA1671 HIP1 GPR45 ADGRL4	1.43e-04	176	67	4	96779273b94345250cf53ba671203345b43d9e00
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNPEP SLCO2B1 PLD3 ADPGK	1.49e-04	178	67	4	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	SYNE1 SH2D3C ADGRL4 DUOXA2	1.66e-04	183	67	4	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-mature_NK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SYNE1 MIB2 CUBN STAT4	1.66e-04	183	67	4	8746e6ecc6bf9e194cc9cdf9b07da63f0fcf8b5f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY2F ADGRV1 DSCAML1 RYR2	1.70e-04	184	67	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY2F ADGRV1 DSCAML1 RYR2	1.70e-04	184	67	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY2F ADGRV1 DSCAML1 RYR2	1.70e-04	184	67	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1671 SLCO2B1 DUOX2 DUOXA2	1.73e-04	185	67	4	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1671 SLCO2B1 DUOX2 DUOXA2	1.73e-04	185	67	4	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	HIP1 SH2D3C DSCAML1 STAT4	1.77e-04	186	67	4	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPEPPS SYNE1 CKAP4 ADPGK	1.81e-04	187	67	4	a7f1656a33b8f88acf655ba609e3858354fff565
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NPEPPS GAREM1 ITPR3	1.81e-04	187	67	4	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NPEPPS GAREM1 ITPR3	1.81e-04	187	67	4	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 NPEPPS GAREM1 ITPR3	1.81e-04	187	67	4	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 FAT2 RETREG3 SLC52A3	1.81e-04	187	67	4	aa336fb568a24e12c0454265ddd71ed10a6614cf
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KIAA1671 SYNE1 SH2D3C ADGRL4	1.88e-04	189	67	4	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KIAA1671 SYNE1 SH2D3C ADGRL4	1.92e-04	190	67	4	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	1.96e-04	191	67	4	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIP1 SLCO2B1 SH2D3C ADGRL4	2.00e-04	192	67	4	945153c41dde6e90d103206955e1707b54eb0665
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIP1 SLCO2B1 SH2D3C ADGRL4	2.00e-04	192	67	4	6ab50579c63f31ca2cd41063a99b129f11c07510
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	2.00e-04	192	67	4	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO2B1 SH2D3C ADGRL4 SLC52A3	2.00e-04	192	67	4	9ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO2B1 SH2D3C ADGRL4 SLC52A3	2.00e-04	192	67	4	a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO2B1 SH2D3C ADGRL4 SLC52A3	2.00e-04	192	67	4	66defad13bd8e79319741e43ddb056841710b1d7
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1671 SLCO2B1 SH2D3C ADGRL4	2.04e-04	193	67	4	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 ZKSCAN8 STAT4 MASP2	2.04e-04	193	67	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	2.04e-04	193	67	4	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)\|Striatum / BrainAtlas - Mouse McCarroll V32	ESPNL CUBN STK31	2.05e-04	76	67	3	3073a8ace46ad18bddd22ec8f3a1b59ee2fd989d
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)-\|Striatum / BrainAtlas - Mouse McCarroll V32	ESPNL CUBN STK31	2.05e-04	76	67	3	3f5865b9cb6648b88eb873018e513c5efb457ae5
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat\|Striatum / BrainAtlas - Mouse McCarroll V32	ESPNL CUBN STK31	2.05e-04	76	67	3	041a8984b3ae4bb03ae6db8234c1333ac73098fa
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	2.08e-04	194	67	4	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 DSCAML1 GAREM1 ITPR3	2.08e-04	194	67	4	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KLK12 DUOX2 DUOXA2 SLC52A3	2.08e-04	194	67	4	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1671 SLCO2B1 SH2D3C ADGRL4	2.08e-04	194	67	4	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1671 SLCO2B1 SH2D3C ADGRL4	2.08e-04	194	67	4	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIP1 SLCO2B1 SH2D3C ADGRL4	2.12e-04	195	67	4	4db30b3bc65c25626f828cd4f867f20c71809898
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	2.12e-04	195	67	4	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C DUOX2 ADGRL4 DUOXA2	2.12e-04	195	67	4	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BMP2 SYNE1 ADGRV1 ITPR3	2.16e-04	196	67	4	7e5addaa844e66f8160e05858c341866a80aed23
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating1_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KIAA1671 SLCO2B1 SH2D3C ADGRL4	2.16e-04	196	67	4	b826dce5b3daa8eb3d4a530b9564de58d9ce3767
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KIAA1671 SLCO2B1 SH2D3C ADGRL4	2.20e-04	197	67	4	4e9221cb02122aed2981c3c9157e847a3710e323
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	2.20e-04	197	67	4	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BMP2 SYNE1 GAREM1 ITPR3	2.20e-04	197	67	4	bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	KIAA1671 SYNE1 SH2D3C ADGRL4	2.20e-04	197	67	4	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-gd_T\|Leuk-UTI / Disease, condition lineage and cell class	KIAA1671 SYNE1 ARHGEF9 STAT4	2.29e-04	199	67	4	b2c1b9ee764e1246bfa3ecf666ca76ae4ac6c362
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KIAA1671 SH2D3C TMEM131L STAT4	2.29e-04	199	67	4	26bb93347e6722abd174dfa62cab692ce2b7eb23
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP2 NPR2 PHTF2 CKAP4	2.33e-04	200	67	4	be527df943a8cedc6452ecef3cafc282db34ceb8
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIAA1671 NBPF19 SYNE1 ADGRV1	2.33e-04	200	67	4	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIAA1671 NBPF19 SYNE1 ADGRV1	2.33e-04	200	67	4	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Lung_Parenchyma-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP2 SYNE1 ADGRV1 ITPR3	2.33e-04	200	67	4	c2bde99b3bc7a8740441c1a0c1394892b940b857
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-gd_T\|Int-URO / Disease, condition lineage and cell class	KIAA1671 SYNE1 STK31 RYR2	2.33e-04	200	67	4	d382ee690e370886009eff42d14952d44a6d4d18
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP2 NPR2 PHTF2 CKAP4	2.33e-04	200	67	4	d254f6634895486f81d7a8b6f006fbc2679eaa5b
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP2 SYNE1 ADGRV1 ITPR3	2.33e-04	200	67	4	3ff9abd5e07780a59d5571da906fa15f00a1d5c2
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP2 NPR2 PHTF2 CKAP4	2.33e-04	200	67	4	8e41a484038216f0c2ad258fd46c0e702a4bb8bf
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIAA1671 NBPF19 SYNE1 ADGRV1	2.33e-04	200	67	4	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	BMP2 ADGRV1 GAREM1 ITPR3	2.33e-04	200	67	4	b535323e18d9fb0dde1e0026df142c831e48c29f
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIAA1671 NBPF19 SYNE1 ADGRV1	2.33e-04	200	67	4	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 NPR2 PHTF2 CKAP4	2.33e-04	200	67	4	c935caef2988f165e96d8f1ef99ae8963ab9377f
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIAA1671 NBPF19 SYNE1 ADGRV1	2.33e-04	200	67	4	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	BMP2 SYNE1 ADGRV1 ITPR3	2.33e-04	200	67	4	9970e9bde6aa2ff3aef60dcb065ff15b7463e147
Drug	Lidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; PC3; HT_HG-U133A	SLC30A5 RNPEPL1 ARHGEF9 ZKSCAN8 KLK12 RYR2 MAST3 ITPR3	1.24e-07	196	68	8	4596_UP
Drug	indo-1/AM	NPR2 ADGRV1 RYR1 RYR2	4.19e-07	21	68	4	CID000123918
Drug	Br2BAPTA	RYR1 RYR2 ITPR3	8.84e-07	7	68	3	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR2 ITPR3	8.84e-07	7	68	3	CID009547999
Drug	R 478	RYR1 RYR2 ITPR3	4.13e-06	11	68	3	CID000084223
Drug	8-amino-cADPR	RYR1 RYR2 ITPR3	4.13e-06	11	68	3	CID003081323
Drug	Gvapspat amide	RYR1 RYR2 ITPR3	1.13e-05	15	68	3	CID000125015
Drug	cobalt-60	SLC30A5 RNPEP NPEPPS GFPT2 PLD3 RYR1 RYR2 ITPR3	2.08e-05	390	68	8	CID000061492
Drug	2-hydroxycarbazole	RYR1 RYR2	2.63e-05	3	68	2	CID000093551
Drug	cis-diammineplatinum(II	RYR1 RYR2	2.63e-05	3	68	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	2.63e-05	3	68	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	2.63e-05	3	68	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	2.63e-05	3	68	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	2.63e-05	3	68	2	CID009570289
Drug	AC1NBU2S	NPR2 GUCY2F RYR1 RYR2 ITPR3	2.65e-05	117	68	5	CID004473765
Drug	PCB74	RYR1 RYR2	5.25e-05	4	68	2	CID000036218
Drug	methyl propynoate	ERVK-6 SYNE1	5.25e-05	4	68	2	CID000013536
Drug	148504-47-6	RYR1 RYR2	5.25e-05	4	68	2	CID006444275
Drug	SC 38249	RYR1 RYR2	5.25e-05	4	68	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	5.25e-05	4	68	2	CID000035682
Drug	T0702	RYR1 RYR2 ITPR3	5.59e-05	25	68	3	CID000005908
Drug	A 68930	RYR1 RYR2	8.74e-05	5	68	2	ctd:C065380
Drug	nisoldipine	RYR1 RYR2 ADGRL4 ITPR3	8.79e-05	78	68	4	CID000004499
Drug	S-nitrosoacetylcysteine	NPR2 GUCY2F RYR1	8.81e-05	29	68	3	CID000122058
Drug	M-HN	HPD RYR1 RYR2	1.08e-04	31	68	3	CID000015450
Drug	XeC compound	NPR2 RYR1 RYR2 ITPR3	1.17e-04	84	68	4	CID000005701
Drug	lysosphingomyelin	PLD3 GPR45 RYR1 RYR2 ITPR3	1.17e-04	160	68	5	CID000005263
Drug	CNS 1145	RYR1 RYR2 ITPR3	1.30e-04	33	68	3	CID000190902
Drug	IHC-64	RYR1 RYR2 ITPR3	1.30e-04	33	68	3	CID000162753
Drug	MBED	RYR1 RYR2	1.31e-04	6	68	2	CID000129958
Drug	chloro-m-cresol	RYR1 RYR2	1.31e-04	6	68	2	CID000012008
Drug	phenyl vinyl sulfone	ERVK-6 SYNE1	1.31e-04	6	68	2	CID000079664
Drug	AC1O528X	RYR1 RYR2	1.31e-04	6	68	2	CID006475857
Drug	NSC114784	RYR1 RYR2	1.31e-04	6	68	2	CID000419425
Drug	AC1Q7BER	RYR1 ITPR3	1.31e-04	6	68	2	CID000005702
Drug	NSC717865	BMP2 AIPL1 ERAS GFPT2 RYR1 RYR2 ITPR3	1.54e-04	387	68	7	CID000005372
Drug	Uroguanylin	NPR2 SLC30A5 GUCY2F	1.70e-04	36	68	3	CID005488765
Drug	aldosterone	NPR2 KLK12 DUOX2 RYR1 RYR2 ADGRL4 ITPR3	1.81e-04	397	68	7	CID000005839
Drug	Azumoleno	RYR1 RYR2	1.83e-04	7	68	2	CID000056259
Drug	TMB-8	BMP2 PLD3 RYR1 RYR2 ITPR3	1.83e-04	176	68	5	CID000005494
Drug	papaverine	NPR2 GUCY2F RYR1 RYR2 ITPR3	1.83e-04	176	68	5	CID000004680
Drug	mag-fura-2	RYR1 RYR2 ITPR3	1.84e-04	37	68	3	CID000123839
Drug	4-chloro-m-cresol	RYR1 RYR2 ITPR3	1.84e-04	37	68	3	CID000001732
Drug	tetrahydrobiopterin	NPR2 FRRS1 HPD GUCY2F DUOX2	1.88e-04	177	68	5	CID000001125
Drug	forskolin from Coleus forskohlii	ERVK-6 BMP2 NPR2 GUCY2F DUOX2 PLD3 RYR1 RYR2 ADGRL4 ITPR3 DUOXA2	1.92e-04	1013	68	11	CID000003413
Drug	AC1L98DX	RYR1 RYR2 ITPR3	1.99e-04	38	68	3	CID000439957
Drug	U46619	BMP2 NPR2 GUCY2F RYR1 RYR2 ITPR3	2.08e-04	285	68	6	CID000005618
Drug	nitrendipine	SLC30A5 RYR1 RYR2 ITPR3	2.13e-04	98	68	4	CID000004507
Drug	NAADP	RYR1 RYR2 ITPR3	2.16e-04	39	68	3	CID000123952
Drug	indo-1	ADGRV1 RYR1 RYR2 ITPR3	2.21e-04	99	68	4	CID000105060
Drug	nitroxyl	NPR2 HPD GUCY2F CKAP4 RYR2	2.31e-04	185	68	5	CID000000945
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	NPR2 HIP1 PHTF2 PLD3 WDR59	2.88e-04	194	68	5	3840_DN
Drug	Trioxsalen [3902-71-4]; Down 200; 17.6uM; PC3; HT_HG-U133A	NPR2 SLC30A5 RNPEPL1 PLD3 CPT2	2.95e-04	195	68	5	5736_DN
Drug	Alverine citrate salt [5560-59-8]; Down 200; 8.4uM; PC3; HT_HG-U133A	ARHGEF9 GFPT2 PLD3 CPT2 PLXNA1	3.02e-04	196	68	5	2110_DN
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A	BMP2 NPR2 HIP1 SLC30A5 PLXNA1	3.02e-04	196	68	5	7269_UP
Drug	Evoxine [522-11-2]; Up 200; 11.6uM; HL60; HT_HG-U133A	CD1A SLCO2B1 GFPT2 PLD3 RYR2	3.09e-04	197	68	5	2186_UP
Drug	Harmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; MCF7; HT_HG-U133A	NPR2 SLC30A5 RNPEPL1 ARHGEF9 PHTF2	3.09e-04	197	68	5	4968_DN
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; MCF7; HT_HG-U133A	SLC30A5 SYNE1 PLXNA1 RYR2 MAST3	3.09e-04	197	68	5	2822_DN
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; PC3; HT_HG-U133A	NPR2 SLC30A5 SYNE1 PHTF2 RYR2	3.09e-04	197	68	5	6663_DN
Drug	(d,l)-Tetrahydroberberine [522-97-4]; Up 200; 11.8uM; HL60; HT_HG-U133A	NPR2 FAT2 SLCO2B1 GFPT2 GAREM1	3.09e-04	197	68	5	2163_UP
Drug	Chlortetracycline hydrochloride [64-72-2]; Down 200; 7.8uM; MCF7; HT_HG-U133A	GFPT2 WDR59 PLXNA1 RYR2 MAST3	3.09e-04	197	68	5	1541_DN
Drug	escina	RYR1 RYR2 ITPR3	3.09e-04	44	68	3	CID006433489
Drug	1,3,5-triethylbenzene	SYNE1 RYR1	3.12e-04	9	68	2	CID000007602
Drug	Propranolol hydrochloride [318-98-9]; Up 200; 13.6uM; MCF7; HT_HG-U133A	NPR2 SLCO2B1 PHTF2 RYR1 STAT4	3.16e-04	198	68	5	3396_UP
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; MCF7; HT_HG-U133A	RNPEPL1 PLD3 CPT2 RYR2 MAST3	3.16e-04	198	68	5	2211_DN
Drug	arachidonyl trifluoromethyl ketone; Down 200; 10uM; MCF7; HG-U133A	WDR59 PLXNA1 MAST3 GAREM1 ITPR3	3.16e-04	198	68	5	594_DN
Drug	Antimycin A [1397-94-0]; Up 200; 7.2uM; PC3; HT_HG-U133A	SLC30A5 SLCO2B1 WDR59 RYR1 ITPR3	3.16e-04	198	68	5	5053_UP
Drug	Bromopride [4093-35-0]; Up 200; 11.6uM; PC3; HT_HG-U133A	BMP2 HIP1 SLC30A5 RYR1 ITPR3	3.16e-04	198	68	5	4278_UP
Drug	Metixene hydrochloride [1553-34-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A	HIP1 SLC30A5 WDR59 PLXNA1 RYR2	3.16e-04	198	68	5	3313_DN
Drug	0175029-0000 [211245-78-2]; Up 200; 10uM; PC3; HT_HG-U133A	CD1A AIPL1 DUOX2 WDR59 RYR1	3.16e-04	198	68	5	3691_UP
Drug	Ergocryptine-alpha [511-09-1]; Down 200; 7uM; MCF7; HT_HG-U133A	NPR2 SLC30A5 RNPEPL1 PHTF2 MAST3	3.16e-04	198	68	5	3900_DN
Drug	Methantheline bromide [53-46-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A	NPR2 RNPEPL1 ARHGEF9 WDR59 MAST3	3.16e-04	198	68	5	6254_UP
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	NPR2 RNPEPL1 PLD3 CPT2 MAST3	3.24e-04	199	68	5	3664_DN
Drug	gadolinium	SLC30A5 ADGRV1 RYR1 RYR2 ITPR3	3.24e-04	199	68	5	CID000023982
Drug	15(S)-15-methyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	SLC30A5 PHTF2 WDR59 GAREM1 ITPR3	3.24e-04	199	68	5	7494_DN
Drug	Torsemide [56211-40-6]; Up 200; 11.4uM; HL60; HT_HG-U133A	SLC30A5 HPD RNPEPL1 RYR2 MAST3	3.24e-04	199	68	5	2956_UP
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A	HIP1 SLC30A5 GFPT2 PLD3 RYR2	3.24e-04	199	68	5	7355_DN
Drug	Oxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	UBR2 NPR2 RNPEPL1 PHTF2 PLD3	3.24e-04	199	68	5	1484_DN
Drug	4,4'-dithiodipyridine	GFPT2 RYR1 RYR2	3.31e-04	45	68	3	CID000075846
Drug	Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; HL60; HT_HG-U133A	HIP1 SLC30A5 RNPEPL1 ARHGEF9 GAREM1	3.31e-04	200	68	5	1871_DN
Drug	Oxytetracycline dihydrate [6153-64-6]; Down 200; 8uM; PC3; HT_HG-U133A	NPR2 HIP1 SLC30A5 PLD3 GAREM1	3.31e-04	200	68	5	5772_DN
Drug	NSC285223	RNPEP SYNE1	3.89e-04	10	68	2	CID000323607
Drug	PCB 95	RYR1 RYR2	3.89e-04	10	68	2	CID000038012
Disease	Transient hypothyroxinaemia of prematurity	DUOX2 DUOXA2	4.63e-06	2	64	2	C3827793
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	1.39e-05	3	64	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	1.39e-05	3	64	2	DOID:8545 (implicated_via_orthology)
Disease	Thyroid Dyshormonogenesis 1	DUOX2 DUOXA2	6.91e-05	6	64	2	C1848805
Disease	basophil percentage of leukocytes	HIP1 SH2D3C MICA CKAP4 RYR1	1.87e-04	243	64	5	EFO_0007992
Disease	Marfan syndrome (implicated_via_orthology)	BMP2 MUS81	2.06e-04	10	64	2	DOID:14323 (implicated_via_orthology)
Disease	Cognitive impairment	RYR2 DMXL1	2.52e-04	11	64	2	HP_0100543
Disease	Graves disease	MICA STAT4 ITPR3	7.36e-04	81	64	3	EFO_0004237
Disease	Autoimmune Hepatitis	MICA STAT4	9.47e-04	21	64	2	EFO_0005676

Protein segments in the cluster

Peptide	Gene	Start	Entry
WIFGVLHVVHASVVT	ADGRL4	631	Q9HBW9
PVVEWHREGISFHFT	ADPGK	451	Q9BRR6
VHEVAEFWCDTIHTG	AIPL1	81	Q9NZN9
ALHWACVNGHAEVVT	ANKRD30B	76	Q9BXX2
DVIIHEISHSWFGNL	RNPEP	321	Q9H4A4
AFSGWCVHHVLEEVQ	CKAP4	121	Q07065
ELDEHYWVVLSSHGE	ADGRV1	851	Q8WXG9
EFVVTLHGHFNWTAR	NPR2	151	P20594
VDVVDSSGWTALHHA	ANKRD24	141	Q8TF21
WTAQGHANHGFVVEV	BMP2	216	P12643
TSHFAWAFHSVAEEE	DMXL1	1571	Q9Y485
TGDSIVSAEAVWDHV	ARHGEF9	6	O43307
TAVHFEHSWGDGVAV	CPT2	366	P23786
AAALAHSWGAHFVET	ERAS	166	Q7Z444
ATSSNALWEVEVVHH	ITPR3	276	Q14573
HWQTFHVSAVAAAAI	MICA	306	Q29983
SVHSWDHVTQGLVEL	FANCI	371	Q9NVI1
THGVLHTKFWVVDQT	PLD3	196	Q8IV08
THGWEAVRAFHKAVT	ESPNL	891	Q6ZVH7
SFQTVWATVFEHHVE	KIAA1671	606	Q9BY89
WATVFEHHVERHTVA	KIAA1671	611	Q9BY89
DWTEQIRHSGFSVTH	KLK12	81	Q9UKR0
FLANVASHHEEIWSA	FAM13B	156	Q9NYF5
HQEWHKFEVSVLVGG	DUOX2	1371	Q9NRD8
EGQDIVLYWEHHSSV	CD1A	286	P06126
AEGSVAREEWHGHVT	NAA20	61	P61599
AREEWHGHVTALSVA	NAA20	66	P61599
ASDWGLTHLVVHEQT	PLXNA1	46	Q9UIW2
TTAGVHVYVWHVGQE	FAT2	3611	Q9NYQ8
EEWHKVFSTCVSHVG	OR51F1	241	A6NGY5
WTTITAHSLEEGHYV	GAREM1	61	Q9H706
WLVHSVAAGSADEAH	NFE2L3	111	Q9Y4A8
EHTVNESAIFHGWVL	COG8	306	Q96MW5
VHVTVDTYSHFIWAT	HERVK_113	666	P63132
SWESFHFIGHEIRIT	METTL21EP	71	A6NDL7
VALVVGHELAHQWFG	NPEPPSL1	346	A6NEC2
VHVTVDTYSHFIWAT	ERVK-7	666	P63135
VHVTVDTYSHFIWAT	ERVK-6	666	Q9BXR3
TAVTLITVRWHFGDH	GPR45	91	Q9Y5Y3
TIFTGHTAVVEDVSW	RBBP4	221	Q09028
IFTGHSAVVEDVAWH	RBBP7	221	Q16576
SAVVEDVAWHLLHES	RBBP7	226	Q16576
DVAWHLLHESLFGSV	RBBP7	231	Q16576
WIHFVTNERVEHIGF	CUBN	2666	O60494
EIVAVHFSAEWFVGT	DUOXA2	66	Q1HG44
EFETHFGIAHTRWAT	GFPT2	81	O94808
GFHSQEVWAGHTVEL	DSCAML1	231	Q8TD84
VAWHVGTEVVLEVHA	FRRS1	521	Q6ZNA5
AHAGVISSDEDIWVH	GUCY2F	186	P51841
QAWSEAVFIHEGYTH	MASP2	511	O00187
VYTVHHVVWSVEDGS	MAST3	976	O60307
HSRLWDAVVGFLHVF	RYR1	3981	P21817
AHSRLWDAVVGFLHV	RYR2	3936	Q92736
VALVVGHELAHQWFG	NPEPPS	346	P55786
ALTKHHSFWVGDVVR	MIB2	321	Q96AX9
FHRFWSVDDTQVHTE	HPD	206	P32754
FLVIDVIHEVAHSWF	RNPEPL1	346	Q9HAU8
VIHEVAHSWFGNAVT	RNPEPL1	351	Q9HAU8
HSVGTVFRDLWHAAF	PHTF2	241	Q8N3S3
TSWVLDGHHSIAFLV	SLC52A3	96	Q9NQ40
SWRSGVAFHSVIHAI	SYNE1	206	Q8NF91
FHIETHENTSGLWSI	TMEM131L	396	A2VDJ0
IGSSSHVEWEDAVHI	NBPF15	241	Q8N660
IGSSSHVEWEDAVHI	NBPF19	241	A0A087WUL8
GTHHEKGAQTFWSVV	HIP1	66	O00291
CHHVAEVWVSGTIFI	RETREG3	141	Q86VR2
VVGSHIEDAVTFWAQ	STK31	36	Q9BXU1
GAWFEAHIHSVTRAS	UHRF2	141	Q96PU4
VIHGSAIDTTCVHWA	SLCO2B1	616	O94956
WVDHSESGEVRFHSV	STAT4	611	Q14765
VHVTVDTYSHFIWAT	ERVK-10	666	P10266
VHVTVDTYSHFIWAT	ERVK-8	666	P63133
VHVTVDTYSHFIWAT	ERVK-11	666	Q9UQG0
HTFVGHDDVVLEFQW	WDR59	276	Q6PJI9
FWRHSASIVAGTIHI	SLC30A5	681	Q8TAD4
WGSTEHGVEVVLAHL	SH2D3C	766	Q8N5H7
HWTVASVSVVQGHFC	UBR2	1376	Q8IWV8
GHRVLWEEVVHSASA	ZKSCAN8	146	Q15776
VTHTVRKLHVGDFVW	MUS81	296	Q96NY9