Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.77e-09	4	131	4	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.77e-09	4	131	4	GO:0045703
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.77e-09	4	131	4	GO:0047743
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.80e-09	5	131	4	GO:0047787
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.63e-08	6	131	4	GO:0045550
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.10e-08	7	131	4	GO:0072582
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.21e-07	8	131	4	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.21e-07	8	131	4	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.21e-07	8	131	4	GO:0035671
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.17e-07	9	131	4	GO:0047044
GeneOntologyMolecularFunction	NADP+ binding	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.17e-07	9	131	4	GO:0070401
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.60e-07	10	131	4	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.60e-07	10	131	4	GO:0032052
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	4.33e-07	24	131	5	GO:0004745
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	6.63e-07	26	131	5	GO:0004022
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	1.41e-06	30	131	5	GO:0018455
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.68e-06	14	131	4	GO:0004032
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.68e-06	14	131	4	GO:0001758
GeneOntologyMolecularFunction	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.90e-06	20	131	4	GO:0004303
GeneOntologyMolecularFunction	NADPH binding	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.36e-05	26	131	4	GO:0070402
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.76e-05	27	131	4	GO:0008106
GeneOntologyMolecularFunction	testosterone dehydrogenase [NAD(P)+] activity	AKR1C4 AKR1C1 AKR1C3	4.38e-05	11	131	3	GO:0030283
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C4 AKR1C1 AKR1C2 NDUFS2 AKR1C3	4.60e-05	60	131	5	GO:0016655
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.52e-05	32	131	4	GO:0004033
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.25e-05	33	131	4	GO:0033764
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.04e-05	34	131	4	GO:0016628
GeneOntologyMolecularFunction	steroid dehydrogenase activity	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.22e-04	39	131	4	GO:0016229
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.35e-04	40	131	4	GO:0016709
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	2.54e-04	4	131	2	GO:0047718
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK5 GRK6	2.54e-04	4	131	2	GO:0047696
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.75e-04	48	131	4	GO:0016620
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	AKR1C4 AKR1C1 AKR1C2 NDUFS2 AKR1C3	4.07e-04	95	131	5	GO:0016651
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.99e-04	56	131	4	GO:0016903
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	CPNE2 CPNE5 CPNE3 CPNE4	6.49e-04	60	131	4	GO:0005544
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.35e-04	62	131	4	GO:0016627
GeneOntologyMolecularFunction	NADP binding	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.35e-04	62	131	4	GO:0050661
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK5 GRK6	8.78e-04	7	131	2	GO:0004703
GeneOntologyMolecularFunction	monooxygenase activity	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.71e-04	115	131	5	GO:0004497
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C SETD7	1.17e-03	8	131	2	GO:0140945
GeneOntologyMolecularFunction	testosterone dehydrogenase (NAD+) activity	AKR1C4 AKR1C3	1.49e-03	9	131	2	GO:0047035
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	1.51e-03	127	131	5	GO:0016616
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP2C9 PHYHD1 AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.78e-03	194	131	6	GO:0016705
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	2.18e-03	138	131	5	GO:0016614
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	NSD2 KMT2C SETD7	3.00e-03	44	131	3	GO:0140938
GeneOntologyMolecularFunction	5'-nucleotidase activity	NT5DC3 NT5DC1	4.24e-03	15	131	2	GO:0008253
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-09	4	126	4	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-09	4	126	4	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-09	4	126	4	GO:0071395
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-09	4	126	4	GO:0008208
GeneOntologyBiologicalProcess	regulation of testosterone biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	3.52e-09	11	126	5	GO:2000224
GeneOntologyBiologicalProcess	farnesol metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.61e-09	5	126	4	GO:0016487
GeneOntologyBiologicalProcess	farnesol catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.61e-09	5	126	4	GO:0016488
GeneOntologyBiologicalProcess	negative regulation of isoprenoid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.61e-09	5	126	4	GO:0045827
GeneOntologyBiologicalProcess	sesquiterpenoid catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.61e-09	5	126	4	GO:0016107
GeneOntologyBiologicalProcess	olefinic compound catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.61e-09	5	126	4	GO:0120256
GeneOntologyBiologicalProcess	negative regulation of retinoic acid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.61e-09	5	126	4	GO:1900053
GeneOntologyBiologicalProcess	sesquiterpenoid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.97e-08	6	126	4	GO:0006714
GeneOntologyBiologicalProcess	polyprenol catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.97e-08	6	126	4	GO:0016095
GeneOntologyBiologicalProcess	testosterone biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	3.25e-08	16	126	5	GO:0061370
GeneOntologyBiologicalProcess	response to prostaglandin D	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.58e-08	7	126	4	GO:0071798
GeneOntologyBiologicalProcess	cellular response to prostaglandin D stimulus	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.58e-08	7	126	4	GO:0071799
GeneOntologyBiologicalProcess	regulation of retinoic acid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.58e-08	7	126	4	GO:1900052
GeneOntologyBiologicalProcess	cellular response to calcium ion	CPNE2 AKR1C4 CPNE5 AKR1C1 AKR1C2 CPNE3 AKR1C3 CPNE4	6.62e-08	88	126	8	GO:0071277
GeneOntologyBiologicalProcess	regulation of retinoic acid receptor signaling pathway	AKR1C4 AKR1C1 AKR1C2 AKR1C3 CNOT1	1.48e-07	21	126	5	GO:0048385
GeneOntologyBiologicalProcess	retinal metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	1.48e-07	21	126	5	GO:0042574
GeneOntologyBiologicalProcess	daunorubicin metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.63e-07	9	126	4	GO:0044597
GeneOntologyBiologicalProcess	parturition	AKR1C4 AKR1C1 AKR1C2 AKR1C3 MMP2	1.90e-07	22	126	5	GO:0007567
GeneOntologyBiologicalProcess	doxorubicin metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.71e-07	10	126	4	GO:0044598
GeneOntologyBiologicalProcess	regulation of isoprenoid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.71e-07	10	126	4	GO:0019747
GeneOntologyBiologicalProcess	negative regulation of vitamin metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.71e-07	10	126	4	GO:0046137
GeneOntologyBiologicalProcess	polyketide metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.71e-07	10	126	4	GO:0030638
GeneOntologyBiologicalProcess	aminoglycoside antibiotic metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.71e-07	10	126	4	GO:0030647
GeneOntologyBiologicalProcess	terpenoid catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.24e-07	11	126	4	GO:0016115
GeneOntologyBiologicalProcess	regulation of ketone biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	4.66e-07	26	126	5	GO:0010566
GeneOntologyBiologicalProcess	response to calcium ion	CPNE2 AKR1C4 CPNE5 AKR1C1 AKR1C2 NEDD4 CPNE3 AKR1C3 CPNE4	6.49e-07	161	126	9	GO:0051592
GeneOntologyBiologicalProcess	retinoic acid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.27e-06	14	126	4	GO:0002138
GeneOntologyBiologicalProcess	isoprenoid catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.27e-06	14	126	4	GO:0008300
GeneOntologyBiologicalProcess	diterpenoid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.72e-06	15	126	4	GO:0016102
GeneOntologyBiologicalProcess	steroid catabolic process	AKR1C4 AKR1C1 AKR1C2 FGF23 AKR1C3	1.90e-06	34	126	5	GO:0006706
GeneOntologyBiologicalProcess	olefinic compound biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	2.20e-06	35	126	5	GO:0120255
GeneOntologyBiologicalProcess	negative regulation of hormone metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.28e-06	16	126	4	GO:0032351
GeneOntologyBiologicalProcess	retinoic acid receptor signaling pathway	AKR1C4 AKR1C1 AKR1C2 AKR1C3 CNOT1	3.35e-06	38	126	5	GO:0048384
GeneOntologyBiologicalProcess	regulation of vitamin metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.80e-06	18	126	4	GO:0030656
GeneOntologyBiologicalProcess	organic hydroxy compound catabolic process	AKR1C4 AKR1C1 AKR1C2 FGF23 SYNJ2 AKR1C3	5.62e-06	73	126	6	GO:1901616
GeneOntologyBiologicalProcess	hormone catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.33e-06	21	126	4	GO:0042447
GeneOntologyBiologicalProcess	terpenoid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.33e-06	21	126	4	GO:0016114
GeneOntologyBiologicalProcess	ketone catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.33e-06	21	126	4	GO:0042182
GeneOntologyBiologicalProcess	glycoside metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.92e-06	22	126	4	GO:0016137
GeneOntologyBiologicalProcess	progesterone metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.92e-06	22	126	4	GO:0042448
GeneOntologyBiologicalProcess	tertiary alcohol metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.92e-06	22	126	4	GO:1902644
GeneOntologyBiologicalProcess	alcohol catabolic process	AKR1C4 AKR1C1 AKR1C2 SYNJ2 AKR1C3	9.81e-06	47	126	5	GO:0046164
GeneOntologyBiologicalProcess	cellular response to prostaglandin stimulus	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.07e-05	23	126	4	GO:0071379
GeneOntologyBiologicalProcess	primary alcohol catabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.07e-05	23	126	4	GO:0034310
GeneOntologyBiologicalProcess	negative regulation of mRNA splicing, via spliceosome	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.43e-05	28	126	4	GO:0048025
GeneOntologyBiologicalProcess	ketone biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	2.55e-05	57	126	5	GO:0042181
GeneOntologyBiologicalProcess	polyprenol metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.80e-05	29	126	4	GO:0016093
GeneOntologyBiologicalProcess	negative regulation of mRNA processing	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.80e-05	29	126	4	GO:0050686
GeneOntologyBiologicalProcess	positive regulation of epithelial cell apoptotic process	AKR1C4 AKR1C1 AKR1C2 MTOR AKR1C3	3.28e-05	60	126	5	GO:1904037
GeneOntologyBiologicalProcess	response to estrogen	AKR1C4 AKR1C1 AKR1C2 AKR1C3 MMP2 ABCC2	4.06e-05	103	126	6	GO:0043627
GeneOntologyBiologicalProcess	positive regulation of endothelial cell apoptotic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.18e-05	32	126	4	GO:2000353
GeneOntologyBiologicalProcess	terpenoid metabolic process	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	4.53e-05	105	126	6	GO:0006721
GeneOntologyBiologicalProcess	negative regulation of RNA splicing	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.74e-05	33	126	4	GO:0033119
GeneOntologyBiologicalProcess	response to metal ion	CPNE2 AKR1C4 CPNE5 AKR1C1 AKR1C2 NEDD4 FGF23 CPNE3 AKR1C3 CPNE4 ABCC2	4.90e-05	415	126	11	GO:0010038
GeneOntologyBiologicalProcess	secondary metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 ABCC2	5.60e-05	67	126	5	GO:0019748
GeneOntologyBiologicalProcess	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	RELN AKR1C4 AKR1C1 AKR1C2 NEDD4 MTOR AKR1C3 MYDGF	5.72e-05	217	126	8	GO:0051897
GeneOntologyBiologicalProcess	cellular response to metal ion	CPNE2 AKR1C4 CPNE5 AKR1C1 AKR1C2 CPNE3 AKR1C3 CPNE4	6.10e-05	219	126	8	GO:0071248
GeneOntologyBiologicalProcess	response to prostaglandin	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.72e-05	36	126	4	GO:0034694
GeneOntologyBiologicalProcess	isoprenoid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.72e-05	36	126	4	GO:0008299
GeneOntologyBiologicalProcess	retinoic acid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.02e-04	40	126	4	GO:0042573
GeneOntologyBiologicalProcess	olefinic compound metabolic process	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5 DKKL1	1.21e-04	180	126	7	GO:0120254
GeneOntologyBiologicalProcess	endothelial cell apoptotic process	AKR1C4 AKR1C1 AKR1C2 MAP3K5 AKR1C3	1.23e-04	79	126	5	GO:0072577
GeneOntologyBiologicalProcess	cellular response to fatty acid	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.24e-04	42	126	4	GO:0071398
GeneOntologyBiologicalProcess	C21-steroid hormone metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.63e-04	45	126	4	GO:0008207
GeneOntologyBiologicalProcess	response to ketone	CACNA1B HDAC6 AKR1C4 SIN3A AKR1C1 AKR1C2 HOXD13 AKR1C3	1.70e-04	254	126	8	GO:1901654
GeneOntologyBiologicalProcess	retinoid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	2.16e-04	89	126	5	GO:0001523
GeneOntologyBiologicalProcess	positive regulation of cholangiocyte proliferation	HDAC6 MTOR	2.20e-04	4	126	2	GO:1904056
GeneOntologyBiologicalProcess	xenobiotic metabolic process	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3 ABCC2	2.31e-04	141	126	6	GO:0006805
GeneOntologyBiologicalProcess	negative regulation of lipid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	2.40e-04	91	126	5	GO:0051055
GeneOntologyBiologicalProcess	intracellular receptor signaling pathway	TRAF6 HDAC6 AKR1C4 AKR1C1 AKR1C2 CARD8 NEDD4 AKR1C3 CNOT1 LILRA4	2.41e-04	416	126	10	GO:0030522
GeneOntologyBiologicalProcess	nuclear receptor-mediated signaling pathway	HDAC6 AKR1C4 AKR1C1 AKR1C2 NEDD4 AKR1C3 CNOT1	2.46e-04	202	126	7	GO:0141193
GeneOntologyBiologicalProcess	isoprenoid metabolic process	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	2.58e-04	144	126	6	GO:0006720
GeneOntologyBiologicalProcess	diterpenoid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	2.79e-04	94	126	5	GO:0016101
GeneOntologyBiologicalProcess	aldehyde metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	2.93e-04	95	126	5	GO:0006081
GeneOntologyBiologicalProcess	glycosyl compound metabolic process	AKR1C4 ADA2 AKR1C1 AKR1C2 AKR1C3	3.08e-04	96	126	5	GO:1901657
GeneOntologyBiologicalProcess	neuron intrinsic apoptotic signaling pathway in response to oxidative stress	MAP3K5 FBXO7 MMP2	3.15e-04	22	126	3	GO:0036480
GeneOntologyBiologicalProcess	prostaglandin metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.81e-04	56	126	4	GO:0006693
GeneOntologyBiologicalProcess	prostanoid metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.08e-04	57	126	4	GO:0006692
GeneOntologyBiologicalProcess	regulation of hormone metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.36e-04	58	126	4	GO:0032350
GeneOntologyBiologicalProcess	multi-multicellular organism process	AKR1C4 AKR1C1 AKR1C2 SLC38A2 MTOR AKR1C3 MMP2 DKKL1	4.55e-04	294	126	8	GO:0044706
GeneOntologyBiologicalProcess	primary alcohol metabolic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	4.86e-04	106	126	5	GO:0034308
GeneOntologyBiologicalProcess	regulation of steroid biosynthetic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3 DKKL1	4.86e-04	106	126	5	GO:0050810
GeneOntologyBiologicalProcess	cellular response to lipid	TRAF6 HDAC6 SASH1 AKR1C4 AKR1C1 AKR1C2 CARD8 NEDD4 FGF23 AKR1C3 CD68 MMP2 CNOT1	6.68e-04	748	126	13	GO:0071396
GeneOntologyBiologicalProcess	cellular response to steroid hormone stimulus	HDAC6 AKR1C4 AKR1C1 AKR1C2 NEDD4 AKR1C3 CNOT1	6.74e-04	239	126	7	GO:0071383
GeneOntologyBiologicalProcess	negative regulation of mRNA metabolic process	AKR1C4 AKR1C1 AKR1C2 MTOR AKR1C3	7.05e-04	115	126	5	GO:1903312
GeneOntologyBiologicalProcess	hormone-mediated signaling pathway	HDAC6 AKR1C4 AKR1C1 AKR1C2 NEDD4 AKR1C3 CNOT1	7.62e-04	244	126	7	GO:0009755
GeneOntologyBiologicalProcess	regulation of lipopolysaccharide-mediated signaling pathway	TRAF6 SASH1 CARD8	8.01e-04	30	126	3	GO:0031664
GeneOntologyBiologicalProcess	response to fatty acid	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.45e-04	69	126	4	GO:0070542
GeneOntologyBiologicalProcess	regulation of cholangiocyte proliferation	HDAC6 MTOR	1.01e-03	8	126	2	GO:1904054
GeneOntologyBiologicalProcess	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	RELN AKR1C4 AKR1C1 AKR1C2 NEDD4 MTOR AKR1C3 MYDGF	1.04e-03	334	126	8	GO:0051896
GeneOntologyBiologicalProcess	regulation of ketone metabolic process	AKR1C4 AKR1C1 AKR1C2 MTOR AKR1C3 DKKL1	1.08e-03	189	126	6	GO:0010565
GeneOntologyBiologicalProcess	regulation of endothelial cell apoptotic process	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.10e-03	74	126	4	GO:2000351
GeneOntologyBiologicalProcess	small molecule catabolic process	ENTPD7 AKR1C4 ADA2 AKR1C1 AKR1C2 FGF23 SYNJ2 MTOR AKR1C3	1.14e-03	421	126	9	GO:0044282
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.14e-03	128	126	5	GO:0033559
GeneOntologyBiologicalProcess	epithelial cell apoptotic process	AKR1C4 AKR1C1 AKR1C2 MAP3K5 MTOR AKR1C3	1.18e-03	192	126	6	GO:1904019
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	HDAC6 APLP1 AKR1C4 SIN3A AKR1C1 AKR1C2 NEDD4 FGF23 AKR1C3 MMP2 CNOT1	1.22e-03	605	126	11	GO:0071407
MousePheno	parturition failure	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.21e-07	10	101	4	MP:0012010
MousePheno	hypermyelination	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.15e-07	11	101	4	MP:0010050
MousePheno	increased oligodendrocyte number	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.75e-06	13	101	4	MP:0010160
MousePheno	increased circulating progesterone level	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.30e-06	15	101	4	MP:0005186
MousePheno	long stride length	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.30e-06	15	101	4	MP:0010540
MousePheno	long gestation period	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.30e-06	15	101	4	MP:0002293
MousePheno	abnormal gestational length	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.27e-06	18	101	4	MP:0002292
MousePheno	dysmyelination	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.14e-05	20	101	4	MP:0013438
MousePheno	decreased oligodendrocyte number	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.89e-05	25	101	4	MP:0009808
MousePheno	prolonged diestrus	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.09e-05	30	101	4	MP:0009011
MousePheno	abnormal parturition	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.94e-05	33	101	4	MP:0002907
MousePheno	abnormal diestrus	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.13e-04	35	101	4	MP:0009010
MousePheno	enhanced coordination	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.57e-04	38	101	4	MP:0003858
MousePheno	prolonged estrous cycle	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.74e-04	39	101	4	MP:0009006
MousePheno	decreased vocalization	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.32e-04	46	101	4	MP:0020351
Domain	Copine	CPNE2 CPNE5 CPNE3 CPNE4	2.50e-07	9	127	4	PF07002
Domain	Copine	CPNE2 CPNE5 CPNE3 CPNE4	2.50e-07	9	127	4	IPR010734
Domain	ALDOKETO_REDUCTASE_1	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.15e-07	10	127	4	PS00798
Domain	ALDOKETO_REDUCTASE_2	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.15e-07	10	127	4	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.15e-07	10	127	4	PS00063
Domain	Aldo/ket_reductase_CS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.15e-07	10	127	4	IPR018170
Domain	Aldo/keto_reductase	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.15e-07	10	127	4	IPR020471
Domain	MORN	MORN4 MORN2 SETD7 MORN5	2.63e-06	15	127	4	IPR003409
Domain	MORN	MORN4 MORN2 SETD7 MORN5	2.63e-06	15	127	4	PF02493
Domain	-	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.48e-06	16	127	4	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.53e-06	17	127	4	IPR023210
Domain	Aldo_ket_red	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.53e-06	17	127	4	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.53e-06	17	127	4	IPR001395
Domain	VWFA	CPNE2 CPNE5 ITIH5 CPNE3 ANTXR1 CPNE4	2.01e-05	82	127	6	PS50234
Domain	VWA	CPNE2 CPNE5 ITIH5 CPNE3 ANTXR1 CPNE4	2.31e-05	84	127	6	SM00327
Domain	VWF_A	CPNE2 CPNE5 ITIH5 CPNE3 ANTXR1 CPNE4	5.87e-05	99	127	6	IPR002035
Domain	MORN	MORN4 MORN2 MORN5	1.06e-04	14	127	3	SM00698
Domain	HAD-SF_hydro_IG_5-nucl	NT5DC3 NT5DC1	2.73e-04	4	127	2	IPR008380
Domain	5_nucleotid	NT5DC3 NT5DC1	2.73e-04	4	127	2	PF05761
Domain	C2	CPNE2 CPNE5 NEDD4 CPNE3 CPNE4 SYTL1	2.74e-04	131	127	6	PF00168
Domain	C2	CPNE2 CPNE5 NEDD4 CPNE3 CPNE4 SYTL1	3.49e-04	137	127	6	SM00239
Domain	C2	CPNE2 CPNE5 NEDD4 CPNE3 CPNE4 SYTL1	4.23e-04	142	127	6	PS50004
Domain	DOCK_N	DOCK1 DOCK5	4.53e-04	5	127	2	PF16172
Domain	DOCK_N	DOCK1 DOCK5	4.53e-04	5	127	2	IPR032376
Domain	-	CPNE2 CPNE5 NEDD4 CPNE3 CPNE4 SYTL1	5.26e-04	148	127	6	2.60.40.150
Domain	C2_dom	CPNE2 CPNE5 NEDD4 CPNE3 CPNE4 SYTL1	9.01e-04	164	127	6	IPR000008
Domain	GPCR_kinase	GRK5 GRK6	9.42e-04	7	127	2	IPR000239
Domain	-	CPNE5 ITIH5 ANTXR1 CPNE4	1.62e-03	74	127	4	3.40.50.410
Domain	DHR-1_domain	DOCK1 DOCK5	2.42e-03	11	127	2	IPR027007
Domain	DHR_2	DOCK1 DOCK5	2.42e-03	11	127	2	PS51651
Domain	DHR_1	DOCK1 DOCK5	2.42e-03	11	127	2	PS51650
Domain	DHR-2	DOCK1 DOCK5	2.42e-03	11	127	2	PF06920
Domain	DOCK	DOCK1 DOCK5	2.42e-03	11	127	2	IPR026791
Domain	DOCK_C	DOCK1 DOCK5	2.42e-03	11	127	2	IPR010703
Domain	DOCK-C2	DOCK1 DOCK5	2.42e-03	11	127	2	PF14429
Domain	DHR-2	DOCK1 DOCK5	2.42e-03	11	127	2	IPR027357
Domain	ZnF_UBP	HDAC6 USP5	2.42e-03	11	127	2	SM00290
Domain	SET	NSD2 KMT2C SETD7	2.71e-03	41	127	3	PF00856
Domain	CarboxyPept_regulatory_dom	CPM CPXM1	3.41e-03	13	127	2	IPR014766
Domain	NCD3G	GRM7 TAS1R2	3.41e-03	13	127	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM7 TAS1R2	3.41e-03	13	127	2	IPR011500
Domain	-	CPM CPXM1	3.41e-03	13	127	2	2.60.40.1120
Domain	SET	NSD2 KMT2C SETD7	3.77e-03	46	127	3	SM00317
Domain	Znf_UBP	HDAC6 USP5	3.96e-03	14	127	2	IPR001607
Domain	zf-UBP	HDAC6 USP5	3.96e-03	14	127	2	PF02148
Domain	ZF_UBP	HDAC6 USP5	3.96e-03	14	127	2	PS50271
Domain	GPCR_3_CS	GRM7 TAS1R2	3.96e-03	14	127	2	IPR017979
Domain	SET_dom	NSD2 KMT2C SETD7	4.77e-03	50	127	3	IPR001214
Domain	SET	NSD2 KMT2C SETD7	4.77e-03	50	127	3	PS50280
Domain	Post-SET_dom	NSD2 KMT2C	5.17e-03	16	127	2	IPR003616
Domain	PostSET	NSD2 KMT2C	5.17e-03	16	127	2	SM00508
Domain	POST_SET	NSD2 KMT2C	5.17e-03	16	127	2	PS50868
Domain	CarboxyPept-like_regulatory	CPM CPXM1	5.84e-03	17	127	2	IPR008969
Domain	Zn_pept	CPM CPXM1	6.54e-03	18	127	2	SM00631
Pathway	WP_BENZOAPYRENE_METABOLISM	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.74e-07	9	88	4	M39344
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.74e-07	9	88	4	M47817
Pathway	KEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.52e-07	11	88	4	M47812
Pathway	REACTOME_RA_BIOSYNTHESIS_PATHWAY	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	7.42e-07	28	88	5	MM15188
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.71e-07	13	88	4	M17842
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.71e-07	13	88	4	MM14747
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.35e-06	14	88	4	M46449
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.35e-06	14	88	4	M27074
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.35e-06	14	88	4	M46453
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.35e-06	14	88	4	MM14748
Pathway	REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.84e-06	15	88	4	MM14870
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.15e-05	23	88	4	M1926
Pathway	REACTOME_PREDNISONE_ADME	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.15e-05	23	88	4	MM16639
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.15e-05	23	88	4	MM14741
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	AKR1C4 AKR1C1 AKR1C2 AKR1C3 SDR16C5	1.30e-05	49	88	5	MM15186
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.05e-05	33	88	4	M5967
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.05e-05	33	88	4	MM14737
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.43e-05	70	88	5	M16794
Pathway	REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.59e-04	44	88	4	M499
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.74e-04	45	88	4	MM15344
Pathway	REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.74e-04	45	88	4	MM14751
Pathway	REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS	AKR1C4 PDPK2P AKR1C1 AKR1C2 AKR1C3 MMP2 SDR16C5	1.89e-04	191	88	7	MM15586
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.79e-04	55	88	4	M14933
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.64e-04	61	88	4	MM14861
Pathway	REACTOME_DRUG_ADME	AKR1C4 AKR1C1 AKR1C2 AKR1C3 ABCC2	8.83e-04	119	88	5	MM15692
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	10500239
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	31479646
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	17034817
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	29764944
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	28329705
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	19237748
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	28259989
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	16511129
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	7789999
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	20124700
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	16508162
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	15222881
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	17629694
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	10526179
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	17272929
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	18667791
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	8274401
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.92e-10	4	131	4	34590152
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	21851338
Pubmed	Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	16984997
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	7737980
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	17872381
Pubmed	Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	17064890
Pubmed	Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	10672042
Pubmed	Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	38788959
Pubmed	Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.58e-10	5	131	4	18003893
Pubmed	Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	19273550
Pubmed	Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	15471942
Pubmed	MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	26748576
Pubmed	The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	29107092
Pubmed	Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	15860270
Pubmed	Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	17122075
Pubmed	Decidual prolactin silences the expression of genes detrimental to pregnancy.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.87e-09	6	131	4	17255200
Pubmed	MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.67e-09	7	131	4	22529366
Pubmed	A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.67e-09	7	131	4	33127481
Pubmed	A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.67e-09	7	131	4	12562828
Pubmed	The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.67e-09	7	131	4	26160177
Pubmed	Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.67e-09	7	131	4	34843575
Pubmed	17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.67e-09	7	131	4	16337335
Pubmed	Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-08	8	131	4	33584538
Pubmed	Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-08	8	131	4	9224647
Pubmed	Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.33e-08	8	131	4	20837989
Pubmed	The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.	CPNE2 CPNE5 CPNE3 CPNE4	2.39e-08	9	131	4	9430674
Pubmed	Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.39e-08	9	131	4	33348080
Pubmed	Lack of placental neurosteroid alters cortical development and female somatosensory function.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.97e-08	10	131	4	36313771
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2 AKR1C3	5.22e-08	3	131	3	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2 AKR1C3	5.22e-08	3	131	3	31780644
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2 AKR1C3	5.22e-08	3	131	3	13678667
Pubmed	Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.	AKR1C4 AKR1C1 AKR1C3	5.22e-08	3	131	3	7626489
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2 AKR1C3	5.22e-08	3	131	3	21232532
Pubmed	A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.30e-08	12	131	4	25774556
Pubmed	Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.30e-08	12	131	4	21256921
Pubmed	Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.30e-08	12	131	4	28893949
Pubmed	The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.34e-07	13	131	4	11682476
Pubmed	A link between lung androgen metabolism and the emergence of mature epithelial type II cells.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.34e-07	13	131	4	15117747
Pubmed	Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.34e-07	13	131	4	24580729
Pubmed	Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.34e-07	13	131	4	17062636
Pubmed	Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.87e-07	14	131	4	19955443
Pubmed	Placental endocrine function shapes cerebellar development and social behavior.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.87e-07	14	131	4	34400844
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	AKR1C4 CPM AKR1C1 AKR1C2 AKR1C3	2.78e-07	37	131	5	21362171
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.40e-07	17	131	4	32243503
Pubmed	Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.	AKR1C1 AKR1C2 AKR1C3	5.19e-07	5	131	3	15212687
Pubmed	Functional dynamics of H3K9 methylation during meiotic prophase progression.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.13e-07	19	131	4	17599069
Pubmed	WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.89e-07	20	131	4	24135228
Pubmed	A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.89e-07	20	131	4	23636947
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	AKR1C4 AKR1C1 AKR1C2 AKR1C3 ABCC2	9.49e-07	47	131	5	11208732
Pubmed	Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.58e-06	52	131	5	23260145
Pubmed	Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.61e-06	23	131	4	23685333
Pubmed	Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.	AKR1C1 AKR1C2 AKR1C3	1.81e-06	7	131	3	19846565
Pubmed	Foxl2 functions in sex determination and histogenesis throughout mouse ovary development.	AKR1C4 AKR1C1 AKR1C2 AKR1C3 MLLT1	2.10e-06	55	131	5	19538736
Pubmed	Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.29e-06	25	131	4	26098214
Pubmed	Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.69e-06	26	131	4	23892084
Pubmed	Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.15e-06	27	131	4	17077188
Pubmed	Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.15e-06	27	131	4	23471215
Pubmed	Identification of differentially expressed genes in mouse spermatogenesis.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.15e-06	27	131	4	14581517
Pubmed	The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.67e-06	28	131	4	29212953
Pubmed	MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.67e-06	28	131	4	29879378
Pubmed	Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.67e-06	28	131	4	21820362
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SASH1 NSD2 HEPH SLC38A2 KMT2C AGO4 NUAK1 SYNJ2 SETD7 CNOT1 MGRN1	5.58e-06	529	131	11	14621295
Pubmed	Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.37e-06	32	131	4	34288113
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	1.41e-05	2	131	2	8573067
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	1.41e-05	2	131	2	15492289
Pubmed	Genome-wide association study for rotator cuff tears identifies two significant single-nucleotide polymorphisms.	SASH1 SAP30BP	1.41e-05	2	131	2	26350878
Pubmed	Proinflammatory Effects of Ubiquitin-Specific Protease 5 (USP5) in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.	TRAF6 USP5	1.41e-05	2	131	2	32214906
Pubmed	Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.	NEDD4 MTOR	1.41e-05	2	131	2	25809873
Pubmed	Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.	AKR1C1 AKR1C3	1.41e-05	2	131	2	30367463
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	1.41e-05	2	131	2	21217827
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	1.41e-05	2	131	2	8486699
Interaction	AKR1C4 interactions	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.10e-07	8	129	4	int:AKR1C4
Interaction	AKR1C3 interactions	HDAC6 AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.68e-06	37	129	5	int:AKR1C3
Interaction	AKR1C1 interactions	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.17e-06	20	129	4	int:AKR1C1
Cytoband	10p15-p14	AKR1C1 AKR1C2 AKR1C3	4.51e-07	6	131	3	10p15-p14
Cytoband	Ensembl 112 genes in cytogenetic band chr10p15	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.34e-04	90	131	4	chr10p15
Cytoband	Ensembl 112 genes in cytogenetic band chr12q15	CPM MYRFL SLC35E3	5.64e-04	56	131	3	chr12q15
GeneFamily	Copines	CPNE2 CPNE5 CPNE3 CPNE4	4.18e-08	9	79	4	829
GeneFamily	Aldo-keto reductases	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.44e-07	15	79	4	399
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD2 KMT2C SETD7	4.36e-04	34	79	3	487
Coexpression	IRITANI_MAD1_TARGETS_UP	AKR1C4 SLC43A3 AKR1C1 AKR1C2 AKR1C3	1.64e-08	17	130	5	MM826
Coexpression	ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF	ENTPD7 TRAF6 GRK6 FNBP1L NT5DC3 NEDD4 DOCK5 SLC38A2 AGO4 SYNJ2 ADAMTS15 SIPA1L2 SDR16C5 CNN3 DOP1A	1.03e-07	550	130	15	M2611
Coexpression	GSE37301_PRO_BCELL_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_UP	CPM ITIH5 NEDD4 CD68 CPNE4 SIPA1L2 CNN3 VAT1	7.00e-07	146	130	8	M8904
Coexpression	INGRAM_SHH_TARGETS_UP	AKR1C4 SIN3A AKR1C1 AKR1C2 DOCK5 INMT AKR1C3 SLC35E3	1.16e-06	156	130	8	MM550
Coexpression	VARELA_ZMPSTE24_TARGETS_DN	AKR1C4 AKR1C1 AKR1C2 INMT AKR1C3	2.89e-06	45	130	5	MM1173
Coexpression	LIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.68e-06	24	130	4	MM766
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.74e-06	25	130	4	MM480
Coexpression	GSE37532_WT_VS_PPARG_KO_VISCERAL_ADIPOSE_TISSUE_TREG_DN	DOCK1 DNAJC13 CANX HEPH PAFAH1B2 DHPS CPNE3 MYDGF	7.32e-06	200	130	8	M8962
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.43e-05	30	130	4	MM853
Coexpression	NADLER_HYPERGLYCEMIA_AT_OBESITY	AKR1C4 AKR1C1 AKR1C2 DHPS AKR1C3	1.95e-05	66	130	5	MM631
Coexpression	DURCHDEWALD_SKIN_CARCINOGENESIS_UP	OLAH NSD2 AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.96e-05	111	130	6	MM705
Coexpression	GOLDRATH_IMMUNE_MEMORY	NCKAP1 AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.42e-05	69	130	5	MM621
Coexpression	DESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.01e-05	36	130	4	MM3660
Coexpression	BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP	RELN SLC43A3 MTOR MLLT1	3.36e-05	37	130	4	M1367
Coexpression	WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.36e-05	37	130	4	MM630
Coexpression	BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP	RELN SLC43A3 MTOR MLLT1	3.74e-05	38	130	4	MM782
Coexpression	PEDRIOLI_MIR31_TARGETS_DN	DOCK1 CWF19L2 PADI4 MAN2C1 CPM DCAF12L2 AKR1C1 AKR1C2 NUDT6 VAT1	4.20e-05	413	130	10	M2494
Coexpression	SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3	AKR1C4 AKR1C1 AKR1C2 ITIH5 AKR1C3	4.67e-05	79	130	5	MM535
Coexpression	GSE5589_WT_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_UP	HDAC6 LRCH2 SASH1 MAP3K5 DOCK5 AGO4 CPNE3	6.49e-05	200	130	7	M6649
Coexpression	GSE15767_MED_VS_SCS_MAC_LN_UP	PLBD1 NRAP SASH1 PHYHD1 AGO4 INMT CD68	6.49e-05	200	130	7	M3584
Coexpression	RAO_BOUND_BY_SALL4_ISOFORM_A	CYP2C9 CANX AKR1C4 AKR1C1 AKR1C2 NEDD4 AKR1C3	8.81e-05	210	130	7	MM958
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPNE2 SEMA3F RELN NRAP SH3GL3 RASIP1 LIG3	1.22e-06	185	130	7	59acaf025353405948dc34ccccf37ec5c08ea903
ToppCell	COVID-19-kidney-Stressed_EC\|kidney / Disease (COVID-19 only), tissue and cell type	SEMA6B SASH1 GRK5 CPNE5 RASIP1 NUAK1 SIPA1L2	1.51e-06	191	130	7	d35aa842b813ea0eff7362abc894cca4e86b2fb2
ToppCell	facs-MAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SASH1 SLC43A3 ITIH5 NEDD4 INMT ANTXR1 MMP2	1.62e-06	193	130	7	f95b95c58a6edb8a03dd15ae166f47f9f33d8bd6
ToppCell	facs-MAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SASH1 SLC43A3 ITIH5 NEDD4 INMT ANTXR1 MMP2	1.62e-06	193	130	7	85faf6c5ce4769615a4eca036e2ba307e176bb52
ToppCell	facs-MAT-Fat-3m-Mesenchymal\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SASH1 SLC43A3 ITIH5 NEDD4 INMT ANTXR1 MMP2	1.62e-06	193	130	7	110a7d2ba7d066c2be38be98b643b76c520dd980
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SASH1 ITIH5 NEDD4 RASIP1 SIPA1L2 CNN3 VAT1	2.06e-06	200	130	7	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	CD8+_Memory_T_cell-FLU-1\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	TRAF6 APLP1 PHYHD1 SLC43A3 CPNE5 CD68	8.19e-06	162	130	6	76f39935763848ea6e7917b2f9f1432c543063d9
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	CACNA1B AKR1C1 AKR1C2 AKR1C3 SIPA1L2 MPPED1	8.79e-06	164	130	6	81c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 RELN SH3GL3 HEPH ITIH5 SAP30BP	1.15e-05	172	130	6	b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCell	facs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 RELN SH3GL3 HEPH ITIH5 SAP30BP	1.15e-05	172	130	6	2f1673fcb2356684d60871debb0f159aec553a1c
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MED20 RELN NT5DC3 AKR1C2 NEDD4 ABCC2	1.23e-05	174	130	6	4a18b51501eaaeb7907e99316ba8ae15b2c7d529
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRK5 AKR1C4 HEPH ALX1 MMP2 MPPED1	1.49e-05	180	130	6	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRK5 AKR1C4 HEPH ALX1 MMP2 MPPED1	1.49e-05	180	130	6	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 CPNE2 TRAF6 RIMKLA DNAJC27 FNBP1L	1.49e-05	180	130	6	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 CPNE2 TRAF6 RIMKLA DNAJC27 FNBP1L	1.49e-05	180	130	6	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SEMA3F LRCH2 SASH1 RASIP1 FGF23 CNN3	1.59e-05	182	130	6	997d37ca2af661c92a56add888762724dfccc890
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SEMA6B CPM NUAK1 CD68 ABCC2 SIPA1L2	1.80e-05	186	130	6	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SEMA6B CPM NUAK1 CD68 ABCC2 SIPA1L2	1.80e-05	186	130	6	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D175\|Adult / Lineage, Cell type, age group and donor	SEMA3F SASH1 GRK5 NEDD4 RASIP1 INMT	1.85e-05	187	130	6	f3548817f2fded5978137bb252cb628ac199e4f6
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLBD1 CPM ITIH5 HOXD13 ADAMTS15 CNN3	1.91e-05	188	130	6	5b69de5baaac45a6d4daa1dbfcb70a7b2ae744ac
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 INMT ANTXR1 CPXM1 MMP2	1.97e-05	189	130	6	bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCell	IPF-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	SASH1 NCKAP1 FNBP1L RASIP1 INMT CNN3	1.97e-05	189	130	6	ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCell	droplet-Lung-LUNG-30m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F SASH1 SLC43A3 FNBP1L RASIP1 CNN3	1.97e-05	189	130	6	25db316f66cee53774bb2b286cc457b37353356c
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 NEDD4 INMT CPXM1 MMP2 VAT1	2.02e-05	190	130	6	dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN AKR1C1 AKR1C2 DOCK5 RASIP1 AKR1C3	2.02e-05	190	130	6	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHYHD1 SLC43A3 ITIH5 INMT CPXM1 MMP2	2.02e-05	190	130	6	8cb950effc449ae59a915132ecc079be54d1acfe
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 NEDD4 INMT CPXM1 MMP2 VAT1	2.02e-05	190	130	6	0bb06df3d5a50416854370f234718c6cec3d773b
ToppCell	facs-SCAT-Fat-24m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 NEDD4 INMT CPXM1 MMP2 VAT1	2.02e-05	190	130	6	008290bb5c79446681dd6bf354336c57ad0d6f13
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHYHD1 SLC43A3 ITIH5 INMT CPXM1 MMP2	2.02e-05	190	130	6	5dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN AKR1C1 AKR1C2 DOCK5 RASIP1 AKR1C3	2.02e-05	190	130	6	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	facs-GAT-Fat-24m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 INMT CPXM1 MMP2	2.02e-05	190	130	6	3720e64129f3f3268b1dc14031a76f41c38241c2
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 INMT CPXM1 MMP2	2.02e-05	190	130	6	73a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 INMT ANTXR1 CPXM1 MMP2	2.02e-05	190	130	6	f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 INMT CPXM1 MMP2	2.02e-05	190	130	6	b55cf1fb586b724295b7b038483249847bb344fc
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHYHD1 SLC43A3 ITIH5 INMT CPXM1 MMP2	2.02e-05	190	130	6	17a73a658fb30a4322b31e38db7b240023738f29
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 INMT ANTXR1 CPXM1 MMP2	2.02e-05	190	130	6	c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCell	droplet-Mammary_Gland-nan-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 NEDD4 INMT ANTXR1 CPXM1 MMP2	2.09e-05	191	130	6	8022059e434fd411dc539819f969bd4f94861281
ToppCell	droplet-Fat-Gat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 INMT CPXM1 MMP2	2.09e-05	191	130	6	850c6fff6dc795431ef534fdaa41e4ad50f7367a
ToppCell	droplet-Fat-Gat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 INMT CPXM1 MMP2	2.09e-05	191	130	6	8b2b00202d3c98bccbae1b4a23713892fad0ff23
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA6B SASH1 CPNE5 RASIP1 NUAK1 SIPA1L2	2.09e-05	191	130	6	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLBD1 CPM ITIH5 HOXD13 ADAMTS15 CNN3	2.09e-05	191	130	6	7411b253b16e4d472be0925dee49188f0fd6b0b5
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 ADAMTS15 ANTXR1 CPXM1 MMP2	2.15e-05	192	130	6	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC43A3 ITIH5 NEDD4 INMT ANTXR1 MMP2	2.15e-05	192	130	6	fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 ADAMTS15 ANTXR1 CPXM1 MMP2	2.15e-05	192	130	6	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLBD1 ADA2 ITIH5 CD68 LILRA4 VAT1	2.15e-05	192	130	6	fb0d05a2c83816794652a6e5af8713e9bb22d5db
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 ADAMTS15 ANTXR1 CPXM1 MMP2	2.15e-05	192	130	6	ac1477433704573f95111eee6263b93668d2845e
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC43A3 ITIH5 NEDD4 INMT ANTXR1 MMP2	2.15e-05	192	130	6	7a2e79490e4f7058bb76b46c45b5df9f729e3146
ToppCell	facs-Trachea-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC43A3 ITIH5 NEDD4 INMT ANTXR1 MMP2	2.15e-05	192	130	6	e8af6ad1ae99cae13a82d0d8d7f38af9b777f0ba
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)\|Adult / Lineage, Cell type, age group and donor	SEMA3F SASH1 GRK5 NEDD4 RASIP1 INMT	2.21e-05	193	130	6	39c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCell	facs-SCAT-Fat-3m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 ANTXR1 CPXM1 MMP2	2.28e-05	194	130	6	14b614f039bc866a1348a2728a68b7d254c7748c
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 ANTXR1 CPXM1 MMP2	2.28e-05	194	130	6	68c7bfead1158641928cc276f599b4a79e06c73c
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F SASH1 NCKAP1 SLC43A3 FNBP1L RASIP1	2.28e-05	194	130	6	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3F SASH1 GRK5 NEDD4 RASIP1 INMT	2.28e-05	194	130	6	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC43A3 ITIH5 NEDD4 ANTXR1 CPXM1 MMP2	2.28e-05	194	130	6	f6aeae6a1e4017e341323fd4784c9e3bae00552b
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC43A3 NEDD4 INMT ANTXR1 CPXM1 MMP2	2.28e-05	194	130	6	889c6e231bdd5b59902c7d2afdc077360b1d3256
ToppCell	IPF-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	SASH1 NCKAP1 FNBP1L RASIP1 NUAK1 CNN3	2.34e-05	195	130	6	120296531bbc8080dcabacbd64733cc1dc34603a
ToppCell	IPF-Endothelial-VE_Peribronchial\|IPF / Disease state, Lineage and Cell class	SASH1 NCKAP1 FNBP1L RASIP1 NUAK1 CNN3	2.34e-05	195	130	6	2c3ad3cb79f11119ac69c413a938d21199145040
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F RELN SASH1 NCKAP1 SH3GL3 RASIP1	2.34e-05	195	130	6	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	facs-Trachea-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITIH5 NEDD4 INMT ANTXR1 MMP2 CNN3	2.34e-05	195	130	6	0d1876f6fdc1eafeb60d6fd7da5bce737d2b4a5a
ToppCell	droplet-Lung-30m-Endothelial-capillary_endothelial-capillary_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEMA3F SLC43A3 FNBP1L NEDD4 RASIP1 CNN3	2.41e-05	196	130	6	9e737eaa98fd49972fce64d1d4a4d1f34b9bcb96
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CANX SLC43A3 ITIH5 NEDD4 MMP2 CNN3	2.41e-05	196	130	6	66d76249bd2770cdddff2c1fe59a016e95da2124
ToppCell	facs-SCAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITIH5 NEDD4 ANTXR1 CPXM1 MMP2 VAT1	2.41e-05	196	130	6	65f2f51e17f1869f3468813127b96d3048d8ad41
ToppCell	facs-SCAT-Fat-18m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITIH5 NEDD4 ANTXR1 CPXM1 MMP2 VAT1	2.41e-05	196	130	6	e4ed897900a6472738bc6be2fb4817192727225d
ToppCell	droplet-Lung-30m-Endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEMA3F SLC43A3 FNBP1L NEDD4 RASIP1 CNN3	2.41e-05	196	130	6	58871891185aa7e1e4ab9b99cd25c1ca3c932cc8
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	PLBD1 SLC43A3 CPM ADA2 CD68 VAT1	2.41e-05	196	130	6	48f7516129570981846c667a07abe5a9abe62dcd
ToppCell	facs-SCAT-Fat-18m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITIH5 NEDD4 ANTXR1 CPXM1 MMP2 VAT1	2.41e-05	196	130	6	2cd83176f2e8a9e6fa3c08cb33928a61e5fc43b6
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CANX SLC43A3 ITIH5 NEDD4 MMP2 CNN3	2.41e-05	196	130	6	9bd4c146fc7555e32adfa393b3a07846eb826d25
ToppCell	droplet-Lung-30m-Endothelial-capillary_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEMA3F SLC43A3 FNBP1L NEDD4 RASIP1 CNN3	2.41e-05	196	130	6	99a7f2e57774884216525897dcd32a289107548b
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	SEMA6B GRK5 CPNE5 RASIP1 NUAK1 SIPA1L2	2.41e-05	196	130	6	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	severe-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ENTPD7 NCKAP1 NT5DC3 RASIP1 KMT2C CPNE3	2.48e-05	197	130	6	70704b149b2820b8601d2495b7cd9cbe91eda262
ToppCell	tumor_Lung-Endothelial_cells-Lymphatic_ECs\|Endothelial_cells / Location, Cell class and cell subclass	RELN LRCH2 DOCK5 SLC38A2 AKR1C3 CNN3	2.48e-05	197	130	6	a05237ee6d31d9eab491dd7007859d6285cf1424
ToppCell	BL-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NCKAP1 MORN2 AKR1C2 SDR16C5 MORN5 CNN3	2.55e-05	198	130	6	6218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCell	356C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PLBD1 AKR1C2 AKR1C3 CPXM1 MMP2 VAT1	2.63e-05	199	130	6	beca4c7eb29ac771fd37f30cd23d4dce4afcfff8
ToppCell	368C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NBEAL1 CANX AKR1C1 AKR1C3 CD68 MMP2	2.63e-05	199	130	6	8766796041965a1ba40ad7abdbc244bf1418c209
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SASH1 FNBP1L ITIH5 RASIP1 INMT CNN3	2.63e-05	199	130	6	7ed541309808f15d65a9c4b26be2050e077539e6
ToppCell	356C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PLBD1 AKR1C2 AKR1C3 CPXM1 MMP2 VAT1	2.63e-05	199	130	6	cd3ab9a75b40e0d417d53b3d8756fc9bed30ac83
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C9 ZC3H12B PHYHD1 AKR1C1 AKR1C2 MMP2	2.63e-05	199	130	6	6f5ef959b51eccf1ffc2e5ddf0d83c62ca2257b2
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2C9 ZC3H12B PHYHD1 AKR1C1 AKR1C2 MMP2	2.63e-05	199	130	6	1aa99d21bf61b86df4a966dc47634044430aa39f
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SEMA3F SASH1 NCKAP1 RASIP1 NUAK1 CNN3	2.63e-05	199	130	6	97052c28e354833901f28d339b09f97f50a5b752
ToppCell	NS-moderate-d_16-33-Epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NCKAP1 AKR1C1 AKR1C2 AKR1C3 SDR16C5 CNN3	2.63e-05	199	130	6	aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCell	368C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NBEAL1 CANX AKR1C1 AKR1C3 CD68 MMP2	2.63e-05	199	130	6	d39b40d84c72bdde756b805063317ecfad3784f8
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SASH1 NCKAP1 NEDD4 RASIP1 SIPA1L2 VAT1	2.70e-05	200	130	6	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3F SEMA6B FNBP1L RASIP1 NUAK1 CNN3	2.70e-05	200	130	6	2989325b0e78ab42f362cfb59e34a4fce7f8e869
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SASH1 ITIH5 NEDD4 RASIP1 CNN3 VAT1	2.70e-05	200	130	6	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SASH1 NCKAP1 NEDD4 RASIP1 SIPA1L2 VAT1	2.70e-05	200	130	6	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Cortical_neuron\|5w / Sample Type, Dataset, Time_group, and Cell type.	RELN SH3GL3 APLP1 FNBP1L AKR1C1 AKR1C2	2.70e-05	200	130	6	085060d148158f7d9e938b6c4a3700ccbb3bca15
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	SASH1 NCKAP1 NEDD4 RASIP1 SIPA1L2 VAT1	2.70e-05	200	130	6	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SASH1 NCKAP1 ITIH5 NEDD4 RASIP1 VAT1	2.70e-05	200	130	6	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	5'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA6B RELN SASH1 RASIP1 NUAK1 CNN3	2.70e-05	200	130	6	2554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	SASH1 ITIH5 NEDD4 RASIP1 SIPA1L2 VAT1	2.70e-05	200	130	6	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	SASH1 ITIH5 NEDD4 RASIP1 SIPA1L2 VAT1	2.70e-05	200	130	6	abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SASH1 NCKAP1 ITIH5 NEDD4 RASIP1 VAT1	2.70e-05	200	130	6	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	tumor_Lung-Fibroblasts\|tumor_Lung / Location, Cell class and cell subclass	ITIH5 INMT ANTXR1 CPXM1 MMP2 CNN3	2.70e-05	200	130	6	073a68b5ce232203ffee86342cba2a00d907e119
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	SASH1 NCKAP1 NEDD4 RASIP1 SIPA1L2 VAT1	2.70e-05	200	130	6	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal\|5w / Sample Type, Dataset, Time_group, and Cell type.	RELN APLP1 CLASP2 FNBP1L AKR1C1 AKR1C2	2.70e-05	200	130	6	9b5753726c17dda98d7384a60f26a5eaf4f6c4d6
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1B RELN TOPAZ1 GRM7 MPPED1	7.89e-05	150	130	5	0205318a870e091add66ee4305747dda9f51510d
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	DOCK1 PHYHD1 CD68 ABCC2 DOP1A	9.78e-05	157	130	5	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MORN2 GRM7 AKR1C2 SIPA1L2 CNN3	1.04e-04	159	130	5	9f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MORN2 GRM7 AKR1C2 SIPA1L2 CNN3	1.04e-04	159	130	5	c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OVCH2 ISL2 ADAMTS15 MORN5 CNN3	1.13e-04	162	130	5	22f1abd20f43bc7e7fc46969da9962faf70ae5d2
Drug	cloxazolam	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.84e-10	4	129	4	ctd:C005522
Drug	Pregnanes	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.84e-10	4	129	4	ctd:D011278
Drug	tetralol	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.84e-10	4	129	4	ctd:C019106
Drug	3',3'',5',5''-tetrabromophenolphthalein	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.84e-10	4	129	4	ctd:C018156
Drug	Hydroxysteroids	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.90e-09	5	129	4	ctd:D006914
Drug	cresolphthalein	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.90e-09	5	129	4	ctd:C010092
Drug	Glipizide	CYP2C9 AKR1C1 AKR1C2 AKR1C3	1.46e-08	6	129	4	ctd:D005913
Drug	Medazepam	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.46e-08	6	129	4	ctd:D008472
Drug	Nitrazepam	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.76e-08	8	129	4	ctd:D009567
Drug	4-hydroxybenzoic acid	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.21e-07	9	129	4	ctd:C038193
Drug	20-alpha-Dihydroprogesterone	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.21e-07	9	129	4	ctd:D004092
Drug	cyclopentanol	AKR1C1 AKR1C2 AKR1C3	1.78e-07	3	129	3	ctd:C016327
Drug	cyclopentanone	AKR1C1 AKR1C2 AKR1C3	1.78e-07	3	129	3	ctd:C007201
Drug	5-dihydrodeoxycorticosterone	AKR1C4 AKR1C1 AKR1C2	1.78e-07	3	129	3	ctd:C454687
Drug	4-benzoylbenzoic acid	AKR1C1 AKR1C2 AKR1C3	1.78e-07	3	129	3	ctd:C058818
Drug	dichloro(4-cymene)ruthenium(II)	AKR1C1 AKR1C2 AKR1C3	1.78e-07	3	129	3	ctd:C530610
Drug	octyl gallate	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.01e-07	10	129	4	ctd:C016627
Drug	Glycyrrhetinic Acid	TRAF6 AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.11e-07	24	129	5	ctd:D006034
Drug	9,10-phenanthrenequinone	AKR1C4 AKR1C1 AKR1C2 AKR1C3 MMP2	2.62e-07	25	129	5	ctd:C005399
Drug	Dihydroxydihydrobenzopyrenes	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.15e-07	11	129	4	ctd:D004101
Drug	chlordecone alcohol	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.15e-07	11	129	4	CID000013946
Drug	Phenolphthalein	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.70e-07	12	129	4	ctd:D020113
Drug	DMBA-3,4-dihydrodiol	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.76e-07	13	129	4	CID000050096
Drug	flunisolide	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.76e-07	13	129	4	ctd:C007734
Drug	tetrahydrodeoxycorticosterone	AKR1C4 AKR1C1 AKR1C2	7.08e-07	4	129	3	ctd:C009413
Drug	gliquidone	AKR1C1 AKR1C2 AKR1C3	7.08e-07	4	129	3	ctd:C010969
Drug	DBD-H	AKR1C4 AKR1C1 AKR1C3	7.08e-07	4	129	3	CID000131382
Drug	5-alpha-Dihydroprogesterone	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.42e-07	14	129	4	ctd:D043582
Drug	1-acenaphthenol	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.42e-07	14	129	4	CID000022750
Drug	Meclofenamic Acid	AKR1C4 AKR1C1 AKR1C2 AKR1C3	9.42e-07	14	129	4	ctd:D008469
Drug	NSC86000	AKR1C1 AKR1C2 AKR1C3	1.76e-06	5	129	3	CID000257630
Drug	Ethambutol dihydrochloride [1070-11-7]; Down 200; 14.4uM; PC3; HG-U133A	PIGN NCKAP1 CANX GRK6 CLASP2 LIG3 EID1 DHPS SLC35E3	1.98e-06	198	129	9	1900_DN
Drug	AC1L93E5	AKR1C4 AKR1C1 AKR1C3	3.51e-06	6	129	3	CID000412383
Drug	Estazolam	AKR1C1 AKR1C2 AKR1C3	3.51e-06	6	129	3	ctd:D004949
Drug	3-hydroxyhexobarbital	AKR1C4 AKR1C2 AKR1C3	3.51e-06	6	129	3	CID000439898
Drug	acenaphthene-1-ol	AKR1C1 AKR1C2 AKR1C3	3.51e-06	6	129	3	ctd:C023723
Drug	oxcarbazepine	AKR1C4 AKR1C1 AKR1C2 AKR1C3	3.57e-06	19	129	4	ctd:C036006
Drug	benzo(a)pyrene-7,8-dione	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.44e-06	20	129	4	ctd:C076588
Drug	Chrysenes	AKR1C4 AKR1C1 AKR1C2 AKR1C3	4.44e-06	20	129	4	ctd:D002911
Drug	Flunitrazepam	AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.46e-06	21	129	4	ctd:D005445
Drug	coniferaldehyde	AKR1C1 AKR1C2 AKR1C3 ABCC2	5.46e-06	21	129	4	ctd:C075384
Drug	naphthalene-1,2-dihydrodiol	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3	5.50e-06	45	129	5	CID000000362
Drug	4-hydroxyequilenin-o-quinone	AKR1C1 AKR1C2 AKR1C3	6.12e-06	7	129	3	ctd:C117714
Drug	zomepirac	AKR1C1 AKR1C2 AKR1C3	6.12e-06	7	129	3	ctd:C020549
Drug	benzene dihydrodiol	AKR1C4 AKR1C1 AKR1C2 AKR1C3	6.65e-06	22	129	4	CID000000418
Drug	2-cyclohexen-1-ol	AKR1C4 AKR1C2 AKR1C3	9.75e-06	8	129	3	CID000013198
Drug	Pregnanolone	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.13e-05	25	129	4	ctd:D011280
Drug	(+,-)-Synephrine [94-07-5]; Down 200; 24uM; MCF7; HT_HG-U133A	SEMA3F MAN2C1 HDAC6 NSD2 MAP3K5 DOCK5 NUDT6 MMP2	1.76e-05	198	129	8	3578_DN
Drug	1,2-dihydroxynaphthalene	CYP2C9 AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.79e-05	57	129	5	CID000011318
Drug	benzo(a)pyrene 7,8-dihydrodiol	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.75e-05	31	129	4	ctd:C017228
Drug	7-hydroxyflavone	CYP2C9 AKR1C1 AKR1C3	2.84e-05	11	129	3	ctd:C429845
Drug	alpha-methylcinnamic acid	AKR1C1 AKR1C3	3.19e-05	2	129	2	ctd:C510582
Drug	(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE	AKR1C1 AKR1C2	3.19e-05	2	129	2	DB07768
Drug	baccharin	AKR1C2 AKR1C3	3.19e-05	2	129	2	ctd:C012764
Drug	fenamic acid	AKR1C1 AKR1C2 AKR1C3	3.77e-05	12	129	3	ctd:C001209
Drug	4-formyl-benzoate	AKR1C4 AKR1C1 AKR1C2	4.88e-05	13	129	3	CID000012088
Drug	quercitrin	AKR1C4 AKR1C1 AKR1C2 ARSL	5.03e-05	36	129	4	CID005280459
Drug	dapsone	CYP2C9 AKR1C4 HOXD13 DHPS MLLT1	5.96e-05	73	129	5	CID000002955
Drug	Dydrogesterone	AKR1C1 AKR1C2 AKR1C3	6.18e-05	14	129	3	ctd:D004394
Drug	6-.beta.-Naltrexol	AKR1C4 AKR1C1 AKR1C2	6.18e-05	14	129	3	CID000631219
Drug	Mefenamic Acid	CYP2C9 AKR1C1 AKR1C2 AKR1C3	6.94e-05	39	129	4	ctd:D008528
Drug	20 alpha-dihydroprogesterone	AKR1C4 AKR1C1 AKR1C2 AKR1C3	7.67e-05	40	129	4	CID000008956
Drug	drospirenone	AKR1C4 AKR1C1 AKR1C2	7.69e-05	15	129	3	ctd:C035144
Drug	o-quinone	AKR1C4 AKR1C1 AKR1C2 AKR1C3	8.47e-05	41	129	4	CID000011421
Drug	9-cis-retinal	AKR1C4 AKR1C1 AKR1C3	9.43e-05	16	129	3	ctd:C031390
Drug	benzo(a)pyrene-1,6-quinone	AKR1C1 AKR1C2 AKR1C3	1.14e-04	17	129	3	ctd:C030233
Drug	Flufenamic Acid	AKR1C4 AKR1C1 AKR1C2 AKR1C3	1.22e-04	45	129	4	ctd:D005439
Drug	Clorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	DOCK1 SEMA3F SASH1 GRK5 APLP1 LIG3 SYNJ2	1.30e-04	196	129	7	7025_UP
Drug	Iron, Dietary	ENTPD7 HEPH MMP2 CNN3	1.33e-04	46	129	4	ctd:D019266
Drug	Ethamivan [304-84-7]; Up 200; 18uM; MCF7; HT_HG-U133A	PIGN HDAC6 SASH1 CLASP2 LIG3 SYNJ2 ANTXR1	1.34e-04	197	129	7	7021_UP
Drug	cloxazolam	AKR1C1 AKR1C2 AKR1C3	1.36e-04	18	129	3	CID000002816
Drug	Ruthenium Compounds	AKR1C1 AKR1C2 AKR1C3	1.36e-04	18	129	3	ctd:D017975
Drug	benzo(a)pyrene-3,6-quinone	AKR1C1 AKR1C2 AKR1C3	1.36e-04	18	129	3	ctd:C018003
Drug	Diflunisal [22494-42-4]; Down 200; 16uM; PC3; HG-U133A	DOCK1 PIGN NCKAP1 CANX GRK6 USP5 EID1	1.38e-04	198	129	7	1908_DN
Drug	STOCK1N-28457; Up 200; 20uM; MCF7; HT_HG-U133A	PIGN RELN APLP1 CLASP2 SYNJ2 MTOR MMP2	1.43e-04	199	129	7	6906_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A	ENTPD7 SEMA3F NSD2 GRM7 LIG3 CDK13 TTC39A	1.43e-04	199	129	7	4982_UP
Drug	Midodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	SEMA3F MAN2C1 GRK5 GRK6 NT5DC3 MAP3K5 SYNJ2	1.47e-04	200	129	7	7156_UP
Drug	pantoprazole	CYP2C9 C4BPA ABCC2	1.61e-04	19	129	3	ctd:C064276
Drug	pipenzolate	HEPH CARD8 VAT1	1.61e-04	19	129	3	CID000004832
Drug	AC1L8ZBW	AKR1C4 AKR1C1 AKR1C2	1.61e-04	19	129	3	CID000435356
Drug	3-pentanone	CYP2C9 HOXD13 SPAG17	1.61e-04	19	129	3	CID000007288
Drug	androstane-3,17-dione	AKR1C4 AKR1C1 AKR1C2 AKR1C3	2.00e-04	51	129	4	CID000000443
Drug	Dutasteride	AKR1C1 AKR1C2 AKR1C3	2.19e-04	21	129	3	ctd:D000068538
Drug	TPGS	MLLT1 SETD7 ABCC2	2.19e-04	21	129	3	CID000071406
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2 AKR1C3	7.79e-08	3	127	3	C0027661
Disease	Hermaphroditism	AKR1C1 AKR1C2 AKR1C3	7.74e-07	5	127	3	C0019269
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2 AKR1C3	7.74e-07	5	127	3	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2 AKR1C3	7.74e-07	5	127	3	C0033804
Disease	Intersex Conditions	AKR1C1 AKR1C2 AKR1C3	7.74e-07	5	127	3	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2 AKR1C3	7.74e-07	5	127	3	C2930619
Disease	Disorders of Sex Development	AKR1C1 AKR1C2 AKR1C3	2.69e-06	7	127	3	C0036875
Disease	MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE	AKR1C4 AKR1C2	1.84e-05	2	127	2	C1839840
Disease	46,XY disorder of sex development due to testicular 17,20-desmolase deficiency	AKR1C4 AKR1C2	1.84e-05	2	127	2	cv:C1839840
Disease	46,XY sex reversal 8 (is_implicated_in)	AKR1C4 AKR1C2	1.84e-05	2	127	2	DOID:0111773 (is_implicated_in)
Disease	46,XY SEX REVERSAL 8	AKR1C4 AKR1C2	1.84e-05	2	127	2	614279
Disease	Rheumatoid Arthritis	PADI4 TRAF6 GRK6 HOXD13 MMP2 ABCC2	1.11e-04	174	127	6	C0003873
Disease	laryngeal carcinoma (is_marker_for)	TRAF6 KMT2C	2.73e-04	6	127	2	DOID:2600 (is_marker_for)
Disease	cortolone glucuronide (1) measurement	AKR1C2 AKR1C3	2.73e-04	6	127	2	EFO_0800552
Disease	parathyroid hormone-related protein measurement	GRK6 ADA2	2.73e-04	6	127	2	EFO_0020622
Disease	glycocholenate sulfate measurement	ENTPD7 ABCC2	2.73e-04	6	127	2	EFO_0800276
Disease	N6-acetyllysine measurement	HDAC6 SLC38A2	8.09e-04	10	127	2	EFO_0800036
Disease	vascular endothelial growth factor D measurement	GRK6 ASB11	9.86e-04	11	127	2	EFO_0010575
Disease	Alcoholic Intoxication, Chronic	NRDC AKR1C4 GRM7 RFX4 AKR1C3 MMP2	1.10e-03	268	127	6	C0001973
Disease	rotator cuff tear	SASH1 SAP30BP	1.18e-03	12	127	2	EFO_1001250
Disease	free androgen index	CASC3 SH3GL3 AKR1C4 SIN3A AKR1C2 DOCK5 AKR1C3	1.21e-03	374	127	7	EFO_0007005
Disease	tryptophan measurement	GRK5 CPM SPAG17	1.24e-03	49	127	3	EFO_0008534
Disease	glycochenodeoxycholate glucuronide (1) measurement	ENTPD7 ABCC2	1.39e-03	13	127	2	EFO_0800474
Disease	platelet component distribution width	GRK5 SIN3A SLC43A3 DOCK5 SYNJ2 DHPS ZBTB10 CD68 ANTXR1 C4BPA	1.62e-03	755	127	10	EFO_0007984
Disease	vascular dementia (biomarker_via_orthology)	MTOR MMP2	1.62e-03	14	127	2	DOID:8725 (biomarker_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	SYNJ2 DOP1A	1.86e-03	15	127	2	DOID:14250 (implicated_via_orthology)
Disease	Endometrial Neoplasms	SEMA3F AKR1C1 AKR1C3	2.02e-03	58	127	3	C0014170
Disease	response to methotrexate	AKR1C1 AKR1C2	2.12e-03	16	127	2	GO_0031427
Disease	X-21441 measurement	ENTPD7 ABCC2	2.40e-03	17	127	2	EFO_0800814
Disease	syndrome (implicated_via_orthology)	NSD2 CNOT1	2.69e-03	18	127	2	DOID:225 (implicated_via_orthology)
Disease	myocardial infarction (implicated_via_orthology)	MAP3K5 MTOR MMP2	2.92e-03	66	127	3	DOID:5844 (implicated_via_orthology)
Disease	Neoplastic Cell Transformation	NSD2 AKR1C1 AKR1C2 AKR1C3	3.12e-03	139	127	4	C0007621
Disease	Cardiomyopathies, Primary	CYP2C9 NDUFS2 MAP3K5	3.32e-03	69	127	3	C0033141
Disease	Myocardial Diseases, Secondary	CYP2C9 NDUFS2 MAP3K5	3.32e-03	69	127	3	C0036529
Disease	urinary microalbumin measurement	MON2 ZCCHC17	3.32e-03	20	127	2	EFO_0010967
Disease	Fetal Growth Retardation	NSD2 MMP2	3.32e-03	20	127	2	C0015934
Disease	end stage renal disease (implicated_via_orthology)	MTOR ABCC2	3.32e-03	20	127	2	DOID:783 (implicated_via_orthology)
Disease	Sclerocystic Ovaries	AKR1C1 AKR1C2 AKR1C3 CMTR2	3.54e-03	144	127	4	C1136382
Disease	Polycystic Ovary Syndrome	AKR1C1 AKR1C2 AKR1C3 CMTR2	3.54e-03	144	127	4	C0032460
Disease	polycystic ovary syndrome (biomarker_via_orthology)	AKR1C3 MMP2	3.66e-03	21	127	2	DOID:11612 (biomarker_via_orthology)
Disease	Endometrial Carcinoma	SEMA3F AKR1C1 AKR1C3	3.74e-03	72	127	3	C0476089

Protein segments in the cluster

Peptide	Gene	Start	Entry
KNSDFYMGAGGPLEH	ALX1	16	Q15699
NDGHFMPVLGFGTYA	AKR1C4	11	P17516
HGEMVSGFGPIYNYK	C4BPA	246	P04003
DYDSDKMFPALGFGA	CPNE2	351	Q96FN4
KVLPGGDTYMHEGFE	ANTXR1	111	Q9H6X2
GFDHFYGMPFSLMGD	ARSL	166	P51690
MKVYYDGTVEQHPFG	C6orf120	131	Q7Z4R8
NDGHFMPVLGFGTYA	AKR1C3	11	P42330
IYFGMPGEISEHEGF	APLP1	296	P51693
YFGPDNTGDIMTLKF	CMTR2	201	Q8IYT2
YDADKMFPAFGFGAQ	CPNE3	336	O75131
NLHGGELVVSYPFDM	CPXM1	496	Q96SM3
YPGEESDKHFMQNFA	DOP1A	1026	Q5JWR5
MEDGPVFYGFKNIFI	ASB11	1	Q8WXH4
HFKMQIFGDRQPGYD	AGO4	71	Q9HCK5
YAQGADSVEPMFKHL	AGO4	486	Q9HCK5
GLEFYMGKFHKACFP	CACNA1B	241	Q00975
YLNAGPMLFSGDKDH	CDK13	1411	Q14004
TGLFTKPMHGYNFVV	ADAMTS15	686	Q8TE58
PFGENCFYKHMYPDG	MKRN4P	416	Q13434
YGFCPHEALFTMGGN	MMP2	271	P08253
ENFEDPMGTIDKFHY	NBEAL1	2081	Q6ZS30
EHFLFMYKDPRTGGS	RASIP1	481	Q5U651
TYKAFLPAMIANDHG	SDR16C5	156	Q8N3Y7
MQHFPGFAYINGEAS	RFX4	716	Q33E94
PDTFSYGGHEDFSKM	RIMKLA	126	Q8IXN7
LSFPYGHLSFGFMQD	CD68	216	P34810
PGGKHNMDFYVEALA	PADI4	241	Q9UM07
YGAHKYQAEFPMSPV	LILRA4	371	P59901
PKVVYFGDSMHSDIF	NT5DC1	306	Q5TFE4
MQAFHSPKALFPVGY	KMT2C	4566	Q8NEZ4
AGMAVYHGKLLDGFF	NEDD4	1061	P46934
HGPTFAKAAQDYCGM	ENTPD7	436	Q9NQZ7
DYLAFHPFDTGMTLG	ITIH5	921	Q86UX2
EYEEHRGKGSFPAMI	NRAP	301	Q86VF7
MKGGFTGGDEYQKHF	INMT	1	O95050
KVNIFDMAGHPFFYE	DNAJC27	66	Q9NZQ0
VDGGLYEHKTFMYPV	ERVFC1-1	196	P60608
PPKSGNYFASHFFMG	MGRN1	26	O60291
FGGMGEFPNALYTHC	DCAF12L2	421	Q5VW00
MDFRGLPGNYHKEEN	DKKL1	76	Q9UK85
GFQMHYEKTPFDQLA	EID1	146	Q9Y6B2
QHTNPGAFGKSDMYI	NUDT6	211	P53370
FPHYFGKEIIGGMLD	CWF19L2	841	Q2TBE0
MKHEIGEFPVFFFGS	NSD2	911	O96028
YKPEFASAMGINTAH	MYRFL	481	Q96LU7
GPFYFMAKEAGIENV	ABCC2	1526	Q92887
EEMEGYGPLKAHPFF	PDPK2P	301	Q6A1A2
HFSSYSKDGIGVPFM	GPR180	226	Q86V85
PALYQHIKTGFNMDD	MON2	1281	Q7Z3U7
FKDYIPQAFPGGHSM	LIG3	541	P49916
QMPYGDVLIHAGDFT	MPPED1	106	O15442
VAGFLEGYLTAPHMN	PLBD1	101	Q6P4A8
SNGHIAYFPAMKAFV	NCKAP1	801	Q9Y2A7
QFGGAVMYPSKETAH	NDUFS2	46	O75306
FYFVMGGICDPGNSH	RELN	476	P78509
SIMEGHYYDPLQFQG	CASC3	541	O15234
DPAVMGGFANYEKAF	DOCK1	1531	Q14185
DPAVMGGFSNYEKAF	DOCK5	1556	Q9H7D0
IYPFDGHNEGTLAMK	FNBP1L	546	Q5T0N5
IGIPEFKYVANMHGD	CPM	71	P14384
IQDNAHMAEGTGFYP	FBXO7	151	Q9Y3I1
LGDMIFFHSYKNPGL	DHPS	241	P49366
MDFRGNIFGSHYFDP	FGF23	96	Q9GZV9
DYDSDKMFPAFGFGA	CPNE4	351	Q96A23
HASLGGFPVEKYMDV	HOXD13	156	P35453
PGEIQHFSKFYAGQM	CARD8	396	Q9Y2G2
LDQFHDKTPYTIMFG	CANX	176	P27824
DDPAMFGAKGLSYDF	ADA2	441	Q9NZK5
ADKERSGPYGFHEMQ	DNAJC13	981	O75165
YALMPHKGSFQDAGV	MAN2C1	906	Q9NTJ4
QMHLGGKQREYEFFG	IL22RA1	176	Q8N6P7
MFNKNGDAPGRYDIF	GRM7	466	Q14831
AHDGPVFAMYALDKG	EML6	901	Q6ZMW3
MFDPHHFLDEGGNFK	CYP2C9	406	P11712
SGYAGFIMPIEVHFK	MLLT1	76	Q03111
LHRYDHGTFFPMGDE	HDAC6	671	Q9UBN7
LKFHIYNMGNPGFEE	GRK5	271	P34947
YHMGQAGFPEARAVF	GRK6	276	P43250
QDKPFAFFGHSMGSY	OLAH	91	Q9NV23
MYIFKQPHFGGEVSP	PHYHD1	141	Q5SRE7
QHYDSDKMFPALGFG	CPNE5	371	Q9HCH3
KMGAPEAGLAEYLFN	FTH1P19	121	P0C7X4
TDSMEDFYPNKNHGP	LRCH2	331	Q5VUJ6
MFDFLHLTGGGYAKI	PAFAH1B2	191	P68402
FGNRHDAVYGPADTM	MED20	176	Q9H944
FHYPFLGAMGDHSKK	ISL2	6	Q96A47
PEAAAGVLEYAMKHF	MTOR	1426	P42345
FYELGEPQAAMFKVG	MAP3K5	881	Q99683
PVFNHTMVYDGFGPA	SYTL1	471	Q8IYJ3
MVFNGPFAHKEGPNY	SEMA3F	381	Q13275
MIHGESGFFPINYVE	SH3GL3	326	Q99963
PMINFDFHQFAKGGK	SYNJ2	331	O15056
GSHVPLEQMSDFYGK	NT5DC3	191	Q86UY8
LKMAGAFQFGHFVGP	OVCH2	146	Q7RTZ1
SMQPHGVFYEKDYEG	HEPH	481	Q9BQS7
GDMYPETHLGRFFAF	KCNV2	461	Q8TDN2
RVENYDHKAMVPFGF	SIPA1L2	216	Q9P2F8
HFELMPGNSVYHFDK	SETD7	181	Q8WTS6
LFKGHPDLIMGFNTF	SIN3A	171	Q96ST3
AFPSEHFGKLFGLVM	SLC43A3	416	Q8NBI5
AGMPFLTGFYSKDHI	MT-ND5	381	P03915
LVYGTMPFDGFDHKN	NUAK1	246	O60285
GEHVPRFFVMYADGS	SPAG17	1636	Q6Q759
NDGHFMPVLGFGTYA	AKR1C1	11	Q04828
NDGHFMPVLGFGTYA	AKR1C2	11	P52895
KTYMGLRNHFPGEAE	CLASP2	276	O75122
MTHFNKGPSYGLSAE	CNN3	1	Q15417
YGMKPHDIFEANDLF	CNN3	96	Q15417
NYEAMIDRAHGGPNF	CNOT1	1816	A5YKK6
EGQFKDNMFHGLGTY	MORN2	16	Q502X0
YDPKHANVALFSDGM	SEMA6B	176	Q9H3T3
CGKAFIYPTSFQGHM	ZNF791	501	Q3KP31
HFAKDCFMQPGGTKY	ZCCHC17	141	Q9NP64
KYETEFHPGTTSFGM	SLC38A2	61	Q96QD8
RNPKGFGYVTFMHLE	TRAF6	466	Q9Y4K3
MGSLKYPDENGFDAF	NRDC	241	O43847
NLKEHMPTFLFNGYE	SASH1	646	O94885
ILPMFAKGASGDHVY	PIGN	141	O95427
ELGTNYPKDMFDPHG	SAP30BP	176	Q9UHR5
TMQDPFGEKRGHFDY	UBE2Z	296	Q9H832
VGFSFAYMGKELPTN	TAS1R2	741	Q8TE23
AEQYPKFESMGDHGY	ZC3H12B	531	Q5HYM0
YKPDGGCMHVAENFS	TOPAZ1	246	Q8N9V7
AYMVLFDFGNLQPGH	VAT1	176	Q99536
SHDFKYGLMPGPSND	ZBTB10	656	Q96DT7
AYLSMFGKEDHKPFG	TTC39A	396	Q5SRH9
GNTSPVTYNMFGHFK	SLC35E3	246	Q7Z769
DGPGKYQLFAFISHM	USP5	796	P45974
DPHYVTFDGRHFGFM	ZAN	1161	Q9Y493
LMFADGGTYLGHFEN	MORN4	31	Q8NDC4
KDGMFHGEGTLYFPS	MORN5	36	Q5VZ52
LQYGAEGGMLHTFFK	AK7	216	Q96M32
FSHNVGPGDKYTCMF	MYDGF	51	Q969H8