Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF567 ZNF135 ZFP90 ZNF143 ZSCAN12 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

4.16e-1114596924GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF135 ZFP90 ZNF143 ZSCAN12 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 NOTCH4 IKZF5 ZNF546 ZNF2 ZNF557

1.48e-1014126923GO:0000981
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF567 ZNF135 ZNF143 ZSCAN12 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 RBAK ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 NOTCH4 IKZF4 IKZF5 ZNF546 ZNF2

5.90e-0912716920GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF567 ZNF135 ZNF143 ZSCAN12 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 RBAK ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 IKZF4 IKZF5 ZNF546 ZNF2

2.53e-0812446919GO:0000978
GeneOntologyMolecularFunctioncalcium ion binding

TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ SPOCK3 ACAN JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

2.20e-077496914GO:0005509
GeneOntologyMolecularFunctionglycosaminoglycan binding

NELL2 STAB2 ZNF146 SPOCK3 ACAN APLP2

3.26e-04268696GO:0005539
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FRAS1 FBLN2 MEGF9 ACAN FBN3

4.84e-04188695GO:0005201
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

STAB2 LRP1

1.37e-0316692GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

STAB2 LRP1

2.37e-0321692GO:0030228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF143 GZF1 ZNF268 ZNF841 ZNF112 ZNF782 NOTCH4

3.16e-03560697GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF143 GZF1 ZNF268 ZNF841 ZNF112 ZNF782 NOTCH4

3.35e-03566697GO:0001216
GeneOntologyMolecularFunctionendopeptidase inhibitor activity

SPOCK3 APLP2 SPINK6 CRB2

3.50e-03180694GO:0004866
GeneOntologyMolecularFunctionNotch binding

JAG1 NOTCH4

3.91e-0327692GO:0005112
GeneOntologyMolecularFunctionscavenger receptor activity

STAB2 LRP1

3.91e-0327692GO:0005044
GeneOntologyMolecularFunctionpeptidase inhibitor activity

SPOCK3 APLP2 SPINK6 CRB2

4.01e-03187694GO:0030414
GeneOntologyMolecularFunctionhyaluronic acid binding

STAB2 ACAN

4.50e-0329692GO:0005540
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZFP90 GZF1 ZNF382 ZNF782 IKZF5

4.99e-03320695GO:0001227
GeneOntologyMolecularFunctionendopeptidase regulator activity

SPOCK3 APLP2 SPINK6 CRB2

5.17e-03201694GO:0061135
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZFP90 GZF1 ZNF382 ZNF782 IKZF5

5.39e-03326695GO:0001217
GeneOntologyBiologicalProcessaorta morphogenesis

TGFB2 JAG1 LRP1 NOTCH4

1.12e-0541704GO:0035909
GeneOntologyBiologicalProcessartery morphogenesis

TGFB2 JAG1 LRP1 NOTCH3 NOTCH4

1.52e-0592705GO:0048844
GeneOntologyBiologicalProcesscardiac chamber development

FZD1 TGFB2 PCSK5 JAG1 LRP1 TEK

8.33e-05212706GO:0003205
GeneOntologyBiologicalProcessartery development

TGFB2 JAG1 LRP1 NOTCH3 NOTCH4

8.94e-05133705GO:0060840
GeneOntologyBiologicalProcesscardiac septum development

FZD1 TGFB2 PCSK5 JAG1 LRP1

9.26e-05134705GO:0003279
GeneOntologyBiologicalProcessaorta development

TGFB2 JAG1 LRP1 NOTCH4

1.58e-0480704GO:0035904
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

FZD1 ZFP90 PRDM11 GZF1 PTPRK ZNF268 ZNF382 RBAK ZNF397 NOTCH3 NOTCH4 IKZF4 IKZF5 NSD3

2.18e-0413997014GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

FZD1 ZFP90 PRDM11 GZF1 PTPRK ZNF268 ZNF382 RBAK ZNF397 NOTCH3 NOTCH4 IKZF4 IKZF5 NSD3

2.41e-0414137014GO:1902679
GeneOntologyBiologicalProcesskidney development

TGFB2 PCSK5 FRAS1 GZF1 JAG1 TEK NOTCH3

2.65e-04372707GO:0001822
GeneOntologyBiologicalProcessrenal system development

TGFB2 PCSK5 FRAS1 GZF1 JAG1 TEK NOTCH3

3.31e-04386707GO:0072001
GeneOntologyBiologicalProcesspositive regulation of cardiac epithelial to mesenchymal transition

TGFB2 JAG1

4.02e-049702GO:0062043
GeneOntologyBiologicalProcessaxon guidance

TGFB2 ABLIM1 NELL2 MEGF9 LRP1 NOTCH3

4.13e-04285706GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

TGFB2 ABLIM1 NELL2 MEGF9 LRP1 NOTCH3

4.20e-04286706GO:0097485
GeneOntologyCellularComponentextracellular matrix

TGFB2 FRAS1 FBLN2 ZAN MEGF9 OTOGL SPOCK3 ACAN MUC5B USH2A FBN3

1.08e-056567011GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

TGFB2 FRAS1 FBLN2 ZAN MEGF9 OTOGL SPOCK3 ACAN MUC5B USH2A FBN3

1.11e-056587011GO:0030312
GeneOntologyCellularComponentbasement membrane

TGFB2 FRAS1 MEGF9 ACAN USH2A

5.57e-05122705GO:0005604
GeneOntologyCellularComponentGolgi lumen

PCSK5 PROZ ACAN MUC5B

4.92e-04109704GO:0005796
DomainEGF

TMEFF1 TPO PCSK5 FRAS1 NELL2 SCUBE1 FBLN2 STAB2 PROZ ZAN MEGF9 JAG1 LRP1 TEK FBN3 NOTCH3 NOTCH4 CRB2

1.76e-192356718SM00181
DomainEGF-like_dom

TMEFF1 TPO PCSK5 FRAS1 NELL2 SCUBE1 FBLN2 STAB2 PROZ ZAN MEGF9 JAG1 LRP1 TEK FBN3 NOTCH3 NOTCH4 CRB2

5.00e-192496718IPR000742
DomainEGF_1

TMEFF1 TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ ZAN MEGF9 JAG1 LRP1 TEK USH2A FBN3 NOTCH3 NOTCH4 CRB2

2.14e-172556717PS00022
Domain-

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

6.38e-1767967233.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

1.03e-166946723IPR013087
DomainEGF-like_CS

TMEFF1 TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ ZAN MEGF9 JAG1 LRP1 TEK FBN3 NOTCH3 NOTCH4 CRB2

7.94e-162616716IPR013032
DomainEGF_2

TMEFF1 TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ ZAN MEGF9 JAG1 LRP1 TEK FBN3 NOTCH3 NOTCH4 CRB2

1.01e-152656716PS01186
DomainZINC_FINGER_C2H2_2

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

1.12e-157756723PS50157
DomainZINC_FINGER_C2H2_1

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

1.18e-157776723PS00028
Domainzf-C2H2

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 ZNF546 ZNF2 ZNF557

1.37e-156936722PF00096
DomainZnf_C2H2-like

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

1.99e-157966723IPR015880
DomainZnf_C2H2

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

2.53e-158056723IPR007087
DomainZnF_C2H2

ZNF567 ZNF135 ZFP90 ZNF143 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

2.74e-158086723SM00355
DomainEGF_3

TMEFF1 TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ ZAN JAG1 LRP1 TEK FBN3 NOTCH3 NOTCH4 CRB2

3.88e-152356715PS50026
DomainEGF_CA

TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

1.54e-141226712SM00179
DomainEGF-like_Ca-bd_dom

TPO NELL2 SCUBE1 FBLN2 STAB2 PROZ JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

1.88e-141246712IPR001881
DomainASX_HYDROXYL

TPO NELL2 SCUBE1 FBLN2 PROZ JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

5.91e-141006711PS00010
DomainKRAB

ZNF567 ZNF135 ZFP90 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF112 ZNF782 ZNF439 ZNF546 ZNF2 ZNF557

1.10e-133586716PS50805
DomainKRAB

ZNF567 ZNF135 ZFP90 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF112 ZNF782 ZNF439 ZNF546 ZNF2 ZNF557

1.10e-133586716PF01352
DomainEGF-type_Asp/Asn_hydroxyl_site

TPO NELL2 SCUBE1 FBLN2 PROZ JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

1.14e-131066711IPR000152
DomainKRAB

ZNF567 ZNF135 ZFP90 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF112 ZNF782 ZNF439 ZNF546 ZNF2 ZNF557

1.75e-133696716SM00349
DomainKRAB

ZNF567 ZNF135 ZFP90 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF112 ZNF782 ZNF439 ZNF546 ZNF2 ZNF557

1.83e-133706716IPR001909
DomainGrowth_fac_rcpt_

PCSK5 FRAS1 NELL2 SCUBE1 FBLN2 STAB2 JAG1 LRP1 TEK FBN3 NOTCH3 NOTCH4

3.03e-131566712IPR009030
DomainEGF_Ca-bd_CS

TPO NELL2 SCUBE1 FBLN2 JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

1.72e-12976710IPR018097
DomainEGF_CA

TPO NELL2 SCUBE1 FBLN2 JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

2.12e-12996710PS01187
DomainEGF_CA

TPO NELL2 SCUBE1 FBLN2 JAG1 LRP1 FBN3 NOTCH3 NOTCH4

2.08e-1186679PF07645
DomainEGF

STAB2 PROZ ZAN JAG1 LRP1 FBN3 NOTCH3 NOTCH4 CRB2

6.67e-10126679PF00008
Domainzf-C2H2_6

ZNF567 ZNF135 ZFP90 GZF1 ZNF157 ZNF382 ZNF558 ZNF805 ZNF841 ZNF782 ZNF439 ZNF546

1.09e-093146712PF13912
DomainVWC_out

FRAS1 NELL2 ZAN JAG1 MUC5B

5.71e-0919675SM00215
DomainhEGF

JAG1 FBN3 NOTCH3 NOTCH4 CRB2

4.70e-0828675PF12661
DomainVWC

FRAS1 NELL2 ZAN JAG1 MUC5B

2.34e-0738675SM00214
DomainVWF_dom

FRAS1 NELL2 ZAN JAG1 MUC5B

3.92e-0742675IPR001007
DomaincEGF

SCUBE1 FBLN2 LRP1 FBN3

2.13e-0626674IPR026823
DomaincEGF

SCUBE1 FBLN2 LRP1 FBN3

2.13e-0626674PF12662
DomainEGF_extracell

NELL2 STAB2 JAG1 TEK NOTCH3

2.39e-0660675IPR013111
DomainEGF_2

NELL2 STAB2 JAG1 TEK NOTCH3

2.39e-0660675PF07974
DomainVWFC_1

FRAS1 NELL2 ZAN MUC5B

8.17e-0636674PS01208
DomainVWFC_2

FRAS1 NELL2 ZAN MUC5B

1.02e-0538674PS50184
DomainNotch

NOTCH3 NOTCH4

7.57e-054672IPR008297
DomainNODP

NOTCH3 NOTCH4

7.57e-054672PF07684
DomainNotch_NODP_dom

NOTCH3 NOTCH4

7.57e-054672IPR011656
DomainNotch_NOD_dom

NOTCH3 NOTCH4

7.57e-054672IPR010660
DomainNOD

NOTCH3 NOTCH4

7.57e-054672PF06816
DomainNOD

NOTCH3 NOTCH4

7.57e-054672SM01338
DomainNODP

NOTCH3 NOTCH4

7.57e-054672SM01339
DomainLNR

NOTCH3 NOTCH4

1.26e-045672PS50258
DomainVWC

FRAS1 NELL2 MUC5B

1.36e-0428673PF00093
DomainEGF_LAM_2

STAB2 MEGF9 USH2A

1.67e-0430673PS50027
DomainEGF_LAM_1

STAB2 MEGF9 USH2A

1.67e-0430673PS01248
DomainNotch_dom

NOTCH3 NOTCH4

2.63e-047672IPR000800
DomainNotch

NOTCH3 NOTCH4

2.63e-047672PF00066
DomainNL

NOTCH3 NOTCH4

2.63e-047672SM00004
DomainEGF_Lam

STAB2 MEGF9 USH2A

2.66e-0435673SM00180
DomainLaminin_EGF

STAB2 MEGF9 USH2A

3.40e-0438673IPR002049
DomainLaminin_G_2

NELL2 USH2A CRB2

3.96e-0440673PF02210
DomainLamG

NELL2 USH2A CRB2

5.26e-0444673SM00282
DomainKAZAL

TMEFF1 SPOCK3 SPINK6

6.00e-0446673SM00280
DomainKAZAL_2

TMEFF1 SPOCK3 SPINK6

7.67e-0450673PS51465
DomainKazal_dom

TMEFF1 SPOCK3 SPINK6

8.12e-0451673IPR002350
DomainEGF_3

SCUBE1 STAB2

8.18e-0412672PF12947
DomainTIL

ZAN MUC5B

8.18e-0412672PF01826
DomainEGF_dom

SCUBE1 STAB2

8.18e-0412672IPR024731
DomainC8

ZAN MUC5B

8.18e-0412672PF08742
DomainUnchr_dom_Cys-rich

ZAN MUC5B

9.64e-0413672IPR014853
DomainC8

ZAN MUC5B

9.64e-0413672SM00832
DomainTIL_dom

ZAN MUC5B

1.12e-0314672IPR002919
DomainConA-like_dom

NELL2 ZAN PTPRK USH2A CRB2

1.13e-03219675IPR013320
DomainLaminin_G

NELL2 USH2A CRB2

1.18e-0358673IPR001791
DomainVWD

ZAN MUC5B

1.47e-0316672SM00216
DomainVWF_type-D

ZAN MUC5B

1.47e-0316672IPR001846
DomainMAM_1

ZAN PTPRK

1.47e-0316672PS00740
DomainVWFD

ZAN MUC5B

1.47e-0316672PS51233
DomainVWD

ZAN MUC5B

1.47e-0316672PF00094
DomainMAM

ZAN PTPRK

1.67e-0317672SM00137
DomainMAM

ZAN PTPRK

1.87e-0318672PF00629
DomainMAM_dom

ZAN PTPRK

1.87e-0318672IPR000998
DomainMAM_2

ZAN PTPRK

1.87e-0318672PS50060
DomainFurin_repeat

PCSK5 FRAS1

1.87e-0318672IPR006212
DomainFU

PCSK5 FRAS1

1.87e-0318672SM00261
DomainEphrin_rec_like

PCSK5 SCUBE1

3.61e-0325672SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

PCSK5 SCUBE1

3.61e-0325672IPR011641
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF567 ZNF135 ZFP90 ZNF143 SRSF7 ZNF157 ZNF268 ZNF382 ZNF436 JAG1 ZNF558 ZNF112 ZNF782 ZNF439 NOTCH3 NOTCH4 ZNF546 ZNF2 ZNF557

1.45e-0713875119M734
PathwayWP_NEOVASCULARIZATION_PROCESSES

TGFB2 JAG1 NOTCH3 NOTCH4

9.19e-0637514M39506
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

JAG1 NOTCH3 NOTCH4

9.59e-0612513M47532
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

JAG1 NOTCH3 NOTCH4

1.24e-0513513M47423
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

JAG1 NOTCH3 NOTCH4

1.23e-0427513M39545
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH3 NOTCH4

1.27e-045512M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH3 NOTCH4

1.27e-045512MM14733
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH3 NOTCH4

1.91e-046512M27068
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH3 NOTCH4

2.66e-047512MM14734
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

FZD1 TGFB2 JAG1 NOTCH3 NOTCH4

2.81e-04161515M39770
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

TGFB2 FBLN2 FBN3

3.18e-0437513M27134
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZFP90 ZNF268 ZNF382 ZNF558 ZNF112 ZNF782 NOTCH3 NOTCH4 ZNF2 ZNF557

3.62e-047685110MM14851
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG1 NOTCH3 NOTCH4

3.72e-0439513MM14604
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

TGFB2 FBLN2 FBN3

5.32e-0444513M26969
PathwayWP_NOTCH_SIGNALING_WP268

JAG1 NOTCH3 NOTCH4

5.69e-0445513M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

JAG1 NOTCH3 NOTCH4

6.07e-0446513MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

JAG1 NOTCH3 NOTCH4

6.47e-0447513M7946
PathwayREACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG1 NOTCH4

6.91e-0411512M27882
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH3 NOTCH4

6.91e-0411512M47865
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

TGFB2 SCUBE1 FBLN2 SPOCK3 ACAN FBN3

7.11e-04300516M610
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH3 NOTCH4

8.28e-0412512M47533
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

FZD1 JAG1 NOTCH3 NOTCH4

8.61e-04118514M39852
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZFP90 SRSF7 ZNF268 ZNF382 ZNF558 ZNF112 ZNF782 NOTCH3 NOTCH4 ZNF2 ZNF557

8.89e-0410225111MM15436
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH3 NOTCH4

9.76e-0413512M47534
PathwayPID_NOTCH_PATHWAY

JAG1 NOTCH3 NOTCH4

1.26e-0359513M17
PathwayWP_NOTCH_SIGNALING_WP61

JAG1 NOTCH3 NOTCH4

1.38e-0361513M39540
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

JAG1 NOTCH4

1.49e-0316512M47424
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

SCUBE1 SPOCK3 ACAN FBN3

1.62e-03140514M587
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

FZD1 LRP1

1.69e-0317512M39525
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ACAN MUC5B NOTCH3 NOTCH4

1.75e-03143514M27275
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH3 NOTCH4

1.89e-0318512M614
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC5B NOTCH3 NOTCH4

1.89e-0368513M27303
PathwayREACTOME_SIGNALING_BY_NOTCH3

JAG1 NOTCH3

2.11e-0319512MM15594
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

TGFB2 SCUBE1 FBLN2 SPOCK3 ACAN

2.33e-03258515MM14572
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH3 NOTCH4

3.09e-0323512MM14954
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

JAG1 NOTCH3 NOTCH4

3.23e-0382513MM15922
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH3 NOTCH4

3.37e-0324512M11190
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG1 NOTCH3

3.65e-0325512M27879
Pubmed

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.

JAG1 TEK NOTCH3 NOTCH4

5.24e-10770411344305
Pubmed

Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.

JAG1 NOTCH3 NOTCH4

7.79e-08570321602525
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

JAG1 NOTCH3 NOTCH4

7.79e-08570315882997
Pubmed

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.

JAG1 NOTCH3 NOTCH4

7.79e-08570320554499
Pubmed

Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.

ZNF135 ZNF436 ZNF397 ZNF546

1.07e-07227041505991
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

TGFB2 JAG1 NOTCH3 NOTCH4

1.29e-072370414701881
Pubmed

A study on Notch signaling in human breast cancer.

JAG1 NOTCH3 NOTCH4

1.55e-07670317822320
Pubmed

Characterization of Notch receptor expression in the developing mammalian heart and liver.

JAG1 NOTCH3 NOTCH4

1.55e-07670312244553
Pubmed

Human ligands of the Notch receptor.

JAG1 NOTCH3 NOTCH4

2.72e-07770310079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG1 NOTCH3 NOTCH4

2.72e-07770312846471
Pubmed

Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.

JAG1 NOTCH3 NOTCH4

4.34e-07870322156581
Pubmed

Notch1 and Jagged1 expression by the developing pulmonary vasculature.

JAG1 NOTCH3 NOTCH4

4.34e-07870312242716
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG1 NOTCH3 NOTCH4

4.34e-0787039858718
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG1 NOTCH3 NOTCH4

6.50e-07970311118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG1 NOTCH3 NOTCH4

6.50e-07970316245338
Pubmed

Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

FBLN2 JAG1 NOTCH3 NOTCH4

7.51e-073570421252157
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG1 NOTCH3 NOTCH4

9.28e-071070323665443
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

JAG1 NOTCH3 NOTCH4

1.27e-061170315499562
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG1 NOTCH3 NOTCH4

1.27e-061170310878608
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

JAG1 NOTCH3 NOTCH4

1.27e-06117039187150
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG1 NOTCH3 NOTCH4

1.27e-061170312866128
Pubmed

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.

JAG1 MUC5B NOTCH3 NOTCH4

1.44e-064170422675208
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG1 NOTCH3 NOTCH4

1.70e-061270315465494
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG1 NOTCH3 NOTCH4

2.20e-061370311578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

JAG1 NOTCH3 NOTCH4

2.20e-061370320558824
Pubmed

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.

TGFB2 JAG1 NOTCH3 NOTCH4

2.74e-064870435247391
Pubmed

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

JAG1 TEK NOTCH3 NOTCH4

2.74e-064870428924218
Pubmed

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

JAG1 NOTCH3 NOTCH4

2.80e-061470328192800
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG1 NOTCH3 NOTCH4

2.80e-061470314757642
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG1 NOTCH3 NOTCH4

3.49e-061570312971992
Pubmed

JAG1-NOTCH4 mechanosensing drives atherosclerosis.

JAG1 NOTCH4

3.99e-06270236044575
Pubmed

Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion.

JAG1 NOTCH3

3.99e-06270218632624
Pubmed

Expression of Jagged1/Notch3 Signaling Pathway and their Relationship with the Tumor Angiogenesis in TNBC.

JAG1 NOTCH3

3.99e-06270228625320
Pubmed

Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.

NOTCH3 NOTCH4

3.99e-06270233665264
Pubmed

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

JAG1 NOTCH4

3.99e-06270226387946
Pubmed

The role of endothelial cell-bound Jagged1 in Notch3-induced human coronary artery smooth muscle cell differentiation.

JAG1 NOTCH3

3.99e-06270222204979
Pubmed

NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.

JAG1 NOTCH3

3.99e-06270219150886
Pubmed

Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.

NOTCH3 NOTCH4

3.99e-06270217696940
Pubmed

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.

JAG1 NOTCH3

3.99e-06270225499214
Pubmed

Regulation of vascular smooth muscle cell phenotype in three-dimensional coculture system by Jagged1-selective Notch3 signaling.

JAG1 NOTCH3

3.99e-06270224138322
Pubmed

Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.

NOTCH3 NOTCH4

3.99e-06270225658374
Pubmed

Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.

JAG1 NOTCH3

3.99e-06270214714274
Pubmed

Protein and mRNA expression of notch pathway components in operable tumors of patients with laryngeal cancer.

JAG1 NOTCH3

3.99e-06270225368251
Pubmed

Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis.

JAG1 NOTCH3

3.99e-06270229610298
Pubmed

Expression of Notch 3 and Jagged 1 Is Associated With Merkel Cell Polyomavirus Status and Prognosis in Merkel Cell Carcinoma.

JAG1 NOTCH3

3.99e-06270230591475
Pubmed

Jagged1/Notch3 Signaling Modulates Hemangioma-Derived Pericyte Proliferation and Maturation.

JAG1 NOTCH3

3.99e-06270227941324
Pubmed

A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.

NOTCH3 NOTCH4

3.99e-06270211777956
Pubmed

TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity.

TGFB2 LRP1

3.99e-06270218804458
Pubmed

Prognostic Subcellular Notch2, Notch3 and Jagged1 Localization Patterns in Early Triple-negative Breast Cancer.

JAG1 NOTCH3

3.99e-06270228476798
Pubmed

Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.

TGFB2 JAG1 NOTCH4

4.29e-061670321352545
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

JAG1 NOTCH3 NOTCH4

4.29e-061670312617809
Pubmed

Notch gene expression during pancreatic organogenesis.

JAG1 NOTCH3 NOTCH4

4.29e-061670310842072
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

JAG1 NOTCH3 NOTCH4

4.29e-061670317273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

JAG1 NOTCH3 NOTCH4

5.20e-061770318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

JAG1 NOTCH3 NOTCH4

5.20e-061770315821257
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

JAG1 NOTCH3 NOTCH4

6.23e-061870318093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

JAG1 NOTCH3 NOTCH4

6.23e-061870315689374
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

JAG1 TEK NOTCH3 NOTCH4

6.30e-065970421421844
Pubmed

The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.

JAG1 TEK NOTCH4

7.39e-061970320627076
Pubmed

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

ACAN JAG1 NOTCH3

7.39e-061970320335360
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

JAG1 NOTCH3 NOTCH4

7.39e-061970316518823
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

JAG1 NOTCH3 NOTCH4

1.01e-052170328656980
Pubmed

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.

JAG1 NOTCH3 NOTCH4

1.01e-052170314702043
Pubmed

Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

JAG1 NOTCH3

1.20e-05370230502484
Pubmed

Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5.

PCSK5 PTPRK

1.20e-05370221094132
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH3 NOTCH4

1.20e-05370225846406
Pubmed

Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.

LRP1 NOTCH3

1.20e-05370220472562
Pubmed

Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma.

JAG1 NOTCH4

1.20e-05370226341090
Pubmed

Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development.

JAG1 NOTCH3

1.20e-0537028923452
Pubmed

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

JAG1 NOTCH3

1.20e-05370212482954
Pubmed

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.

JAG1 NOTCH4

1.20e-05370214988227
Pubmed

Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.

JAG1 NOTCH4

1.20e-05370215939383
Pubmed

Targeted genome modification in mice using zinc-finger nucleases.

JAG1 NOTCH3

1.20e-05370220628038
Pubmed

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

NOTCH3 NOTCH4

1.20e-05370215645445
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

JAG1 NOTCH3 NOTCH4

1.34e-052370336239412
Pubmed

Rbpj regulates development of prosensory cells in the mammalian inner ear.

JAG1 NOTCH3 NOTCH4

1.53e-052470321420948
Pubmed

Loss of Gata5 in mice leads to bicuspid aortic valve.

JAG1 TEK NOTCH4

1.53e-052470321633169
Pubmed

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.

JAG1 NOTCH3 NOTCH4

1.96e-052670325446530
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

ACAN JAG1 NOTCH3

1.96e-052670334189436
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

JAG1 NOTCH3 NOTCH4

1.96e-052670319369401
Pubmed

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.

JAG1 NOTCH3 NOTCH4

2.21e-052770321791528
Pubmed

Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.

TGFB2 ACAN NOTCH4

2.21e-052770335894043
Pubmed

Thrombospondin 2 potentiates notch3/jagged1 signaling.

JAG1 NOTCH3

2.39e-05470219147503
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH3 NOTCH4

2.39e-05470228061457
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH3 NOTCH4

2.39e-05470224145721
Pubmed

Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers.

IKZF4 IKZF5

2.39e-05470215491138
Pubmed

APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo.

LRP1 APLP2

2.39e-05470228495363
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH3 NOTCH4

2.39e-05470220069356
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH3 NOTCH4

2.39e-05470219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH3 NOTCH4

2.39e-05470228669409
Pubmed

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.

JAG1 NOTCH3

2.39e-05470218060036
Pubmed

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.

JAG1 NOTCH3

2.39e-05470210551863
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH3 NOTCH4

2.39e-05470211466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH3 NOTCH4

2.39e-05470224151014
Pubmed

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

JAG1 NOTCH4

2.39e-05470217984306
Pubmed

Activation of Notch signaling in human tongue carcinoma.

JAG1 NOTCH3

2.39e-05470220819128
Pubmed

TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.

TGFB2 MUC5B

2.39e-05470223249391
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH3 NOTCH4

2.39e-05470211401408
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH3 NOTCH4

2.39e-05470210194420
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH3 NOTCH4

2.39e-0547028898100
InteractionZSCAN21 interactions

FRAS1 FBLN2 ZSCAN12 GZF1 ZNF382 RBAK ZNF397

3.04e-07128707int:ZSCAN21
InteractionZNF74 interactions

PTPRK RBAK NOTCH3 IKZF4

5.72e-0634704int:ZNF74
InteractionZNF473 interactions

ZSCAN12 GZF1 ZNF382 RBAK

4.28e-0556704int:ZNF473
InteractionZFP41 interactions

FRAS1 NELL2 LRP1 NOTCH3

4.59e-0557704int:ZFP41
InteractionLYPD1 interactions

PCSK5 FRAS1 ZNF146 PTPRK

4.91e-0558704int:LYPD1
InteractionZNF787 interactions

GZF1 ZNF382 RBAK NBR1

7.25e-0564704int:ZNF787
InteractionEGFL7 interactions

NELL2 PROZ NOTCH3 NOTCH4

1.49e-0477704int:EGFL7
InteractionLGALS1 interactions

FRAS1 MEGF9 PTPRK JAG1 SNRNP40 NBR1 NOTCH3

1.52e-04332707int:LGALS1
InteractionZNF710 interactions

GZF1 ZNF382 RBAK

1.52e-0430703int:ZNF710
InteractionZFP3 interactions

GZF1 ZNF382 RBAK

1.52e-0430703int:ZFP3
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF567 ZNF135 ZNF146 ZNF382 ZNF805 ZNF841 ZNF112 ZNF546

4.58e-041192708chr19q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF567 ZNF135 ZFP90 ZNF143 ZSCAN12 ZNF146 GZF1 ZNF157 ZNF268 ZNF382 ZNF436 RBAK ZNF558 ZNF805 ZNF397 ZNF841 ZNF112 ZNF782 ZNF439 IKZF4 IKZF5 ZNF546 ZNF2 ZNF557

5.83e-19718582428
CoexpressionNABA_MATRISOME

TGFB2 TPO PCSK5 FRAS1 NELL2 SCUBE1 FBLN2 MEGF9 SPOCK3 ACAN MUC5B USH2A FBN3

2.81e-0610267013M5889
CoexpressionNABA_CORE_MATRISOME

FRAS1 NELL2 FBLN2 SPOCK3 ACAN USH2A FBN3

8.84e-06275707M5884
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG1 NOTCH3 NOTCH4

9.96e-0616703MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG1 NOTCH3 NOTCH4

9.96e-0616703M2207
CoexpressionNABA_MATRISOME

TGFB2 TPO PCSK5 FRAS1 NELL2 SCUBE1 FBLN2 MEGF9 OTOGL SPOCK3 ACAN MUC5B

1.33e-0510087012MM17056
CoexpressionGSE2706_UNSTIM_VS_2H_LPS_DC_UP

ZNF567 ZNF268 RBAK ZNF805 ZNF397 ZNF439

1.47e-05197706M4695
CoexpressionMURAKAMI_UV_RESPONSE_6HR_DN

TGFB2 ACAN NOTCH4

2.34e-0521703M16756
CoexpressionBLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_UP

ZNF567 ZNF143 GZF1 RBAK ZNF805 ZNF112 IKZF5 ZNF557

4.55e-05486708M34018
CoexpressionPEREZ_TP63_TARGETS

FZD1 PCSK5 ZNF436 JAG1 PRSS33 ZNF439 NOTCH3

4.62e-05356707M10761
CoexpressionNABA_CORE_MATRISOME

FRAS1 NELL2 FBLN2 OTOGL SPOCK3 ACAN

8.53e-05270706MM17057
CoexpressionHALLMARK_NOTCH_SIGNALING

FZD1 JAG1 NOTCH3

8.56e-0532703M5903
CoexpressionLIU_CDX2_TARGETS_UP

JAG1 NOTCH3 NOTCH4

1.12e-0435703M16637
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPROGBP

FZD1 NELL2 SCUBE1 FBLN2 CRB2 SHISA3

1.52e-04300706M39059
CoexpressionGSE11057_NAIVE_VS_MEMORY_CD4_TCELL_UP

PCSK5 ABLIM1 PTPRK SNX9 ZNF546

1.77e-04195705M3118
CoexpressionNABA_ECM_GLYCOPROTEINS

FRAS1 NELL2 FBLN2 USH2A FBN3

1.81e-04196705M3008
CoexpressionGSE37534_UNTREATED_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP

TGFB2 PRDM11 PROZ ACAN LRP1

1.86e-04197705M8983
CoexpressionHALLMARK_WNT_BETA_CATENIN_SIGNALING

FZD1 JAG1 NOTCH4

1.94e-0442703M5895
CoexpressionGSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN

ZNF135 PTPRK APLP2 NSD3 ZNF557

1.95e-04199705M9236
CoexpressionGSE23984_CTRL_VS_HYPOCALEMIC_VITAMIND_ANALOG_TCELL_DN

STAB2 FRMD6 LRP1 APLP2 NSD3

1.99e-04200705M8052
CoexpressionGSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_45MIN_UP

TSPAN17 ZSCAN12 LRP1 MTURN SNX9

1.99e-04200705M6629
CoexpressionGSE360_DC_VS_MAC_L_MAJOR_UP

PCSK5 ZNF157 PTPRK CRISP1 MUC5B

1.99e-04200705M5181
CoexpressionGSE21774_CD62L_POS_CD56_BRIGHT_VS_CD62L_NEG_CD56_DIM_NK_CELL_DN

ZNF397 CHD6 MTURN ZNF841 NSD3

1.99e-04200705M7495
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

TPO PCSK5 ABLIM1 FBLN2 JAG1 TEK NOTCH4

1.36e-081797072a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellmetastatic_Lymph_Node-T/NK_cells-Exhausted_Tfh|metastatic_Lymph_Node / Location, Cell class and cell subclass

NELL2 SCUBE1 PRDM11 TSPAN17 SNX9 IKZF4

2.76e-07169706ad9054ee09033b648a76baf1b2ec4a6ab1394bde
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 STAB2 ZAN OTOGL MUC5B USH2A

4.55e-071847062cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 STAB2 ZAN OTOGL MUC5B USH2A

4.55e-07184706ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 STAB2 ZAN OTOGL MUC5B USH2A

4.55e-071847062b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 TEK NOTCH4

5.32e-071897062ce330d8078833c05775c481e73770f9ee4a5c88
ToppCelldroplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 TEK NOTCH4

5.32e-07189706473c87036e04a058b4a5138438b7ba7e1e766799
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 ABLIM1 FBLN2 JAG1 TEK NOTCH4

5.49e-07190706aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 TEK NOTCH4

5.84e-07192706c0498baa2556e1597c00df2e75efadeb14bd34ef
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 TEK NOTCH4

5.84e-07192706cb906b10cad76e978c5c0b966215368ebef30e51
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 TEK NOTCH4

5.84e-07192706144503af50274eaed5cf6effa892c640eab28663
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 TEK NOTCH4

5.84e-07192706c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FZD1 PCSK5 SCUBE1 FRMD6 LRP1 NOTCH3

6.78e-071977065afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FZD1 PCSK5 SCUBE1 FRMD6 LRP1 NOTCH3

6.78e-071977061baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FZD1 PCSK5 SCUBE1 FRMD6 LRP1 NOTCH3

6.78e-07197706b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FRAS1 ZAN OTOGL SPOCK3 USH2A

5.70e-06162705bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 FBLN2 JAG1 TEK NOTCH4

5.70e-0616270525bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

ZFP90 PRDM11 ZNF782 NOTCH4 ZNF557

6.42e-06166705c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFB2 NELL2 FBLN2 FRMD6 SPOCK3

7.00e-061697052456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPO FRAS1 ZAN OTOGL USH2A

7.00e-0616970512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 ABLIM1 FBLN2 JAG1 TEK

7.84e-06173705b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

8.52e-0617670577516048aefbe1f48e825052756df0c310c1c486
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

8.52e-0617670596779273b94345250cf53ba671203345b43d9e00
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TPO FBLN2 JAG1 TEK NOTCH4

9.00e-061787055f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 FBLN2 JAG1 TEK NOTCH4

9.25e-061797051ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

9.76e-061817054d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFB2 PCSK5 FRAS1 NELL2 FBLN2

1.00e-05182705ecb5624c9074cc6449fad961df54c926c2681d54
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.03e-051837053427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.14e-0518770566ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 PCSK5 FBLN2 JAG1 NOTCH4

1.14e-05187705e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.17e-051887055bc1537e079c7435196c163bff5f639ea392a33a
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.20e-051897059da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABLIM1 FBLN2 JAG1 TEK NOTCH4

1.20e-05189705c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 FBLN2 JAG1 TEK NOTCH4

1.23e-05190705cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.23e-05190705eae5bcdb8a35f3fba4d25854c1a43f83f80832a2
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFB2 FBLN2 JAG1 TEK NOTCH4

1.23e-051907055bf3d0beee69879c95265d07fba023626a7cc808
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.23e-05190705d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.23e-051907053346bfd0474828b3729cffa9f4cc57b04dd30443
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.27e-051917053307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.27e-0519170504c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 APLP2 TEK

1.27e-05191705b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.27e-05191705db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABLIM1 NELL2 FBLN2 PTPRK IKZF5

1.27e-05191705696921a4f160b6b55698652488ed781e855e5e51
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.27e-051917054b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.27e-05191705b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.30e-05192705285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCUBE1 PTPRK APLP2 TEK NOTCH4

1.30e-051927054bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TPO FRAS1 STAB2 ZAN USH2A

1.33e-05193705315840bc48899f3a36d57b19197509de19716e3d
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FZD1 FRAS1 FRMD6 JAG1 NOTCH3

1.33e-05193705cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.33e-051937053a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FZD1 FRAS1 FRMD6 JAG1 NOTCH3

1.33e-051937056ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FZD1 FRAS1 FRMD6 JAG1 NOTCH3

1.33e-05193705e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCellsevere-Myeloid-CD16_Monocytes|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FZD1 LRP1 SNX9 NOTCH3 NOTCH4

1.36e-051947051b33248b8a7cb914783bcf9e6a80481b4db7e0e8
ToppCellCOVID-19_Mild-CD8+_T_naive|COVID-19_Mild / Disease condition and Cell class

PCSK5 ABLIM1 NELL2 FBLN2 PTPRK

1.36e-051947054e42df4f6db456ab914ddfb2a938dfc462f8b6bf
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.40e-0519570575db19c0371320ea5fce1d6de8c1b40b1e6a2e58
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.40e-05195705b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 FRAS1 NELL2 FBLN2 SPOCK3

1.47e-05197705bb35a2b7320fda92e9cd42f536b7bd54e3a73a32
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.51e-051987055e781583908c4ee107d986904a646a7c6b8e3591
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.54e-05199705a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.54e-051997059b02acae6325b0ac9642438a4431285ff396e5fe
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFB2 FRAS1 NELL2 FBLN2 SPOCK3

1.54e-05199705a76aa30fb264bdcbc0cb09113f814fc5a89e7319
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFB2 PCSK5 FRAS1 NELL2 FBLN2

1.54e-051997051761669ec514fdb4175042f11b9a31fa5687fc2b
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABLIM1 FRMD6 PTPRK TEK NOTCH4

1.58e-05200705032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FRAS1 FRMD6 JAG1 SLC6A20 NOTCH3

1.58e-05200705ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABLIM1 FRMD6 PTPRK TEK NOTCH4

1.58e-0520070568fce28690246895fd33354b30960ebcc31aa4cc
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 FBLN2 JAG1 TEK NOTCH4

1.58e-0520070593e13937ec74418a697c37d56f57509fb2154780
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABLIM1 FRMD6 PTPRK TEK NOTCH4

1.58e-05200705376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABLIM1 FRMD6 PTPRK TEK NOTCH4

1.58e-052007057fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABLIM1 FRMD6 PTPRK TEK NOTCH4

1.58e-05200705878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABLIM1 FRMD6 PTPRK TEK NOTCH4

1.58e-052007057136936d05ab344a560cf159684c881063b5430d
ToppCellCOVID-19_Severe-Neu_3|World / 5 Neutrophil clusters in COVID-19 patients

TGFB2 FRAS1 PRDM11 ALDH3B2

4.38e-0512470454b42ffb161eece4ae308782e43a0e0dc360281e
ToppCellprimary_visual_cortex|World / Per Region, Lineage, Cell class, Cell type, Cell subtype

FBLN2 FRMD6 SPOCK3 SHISA3

7.22e-05141704605d7b28e99c943f64b4095855a6f9f70e92cb09
ToppCell10x5'-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

TGFB2 ZNF112 ZNF546 ZNF2

7.22e-051417047671d300b1722711fd2d8034b96a3aa7e3ccb560
ToppCellLPS-IL1RA-Endothelial-Mes-Like-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ALLC ZNF436 ZNF558 USH2A

7.42e-05142704c3a5a80f78704d34db5df85d6e3e8fc84ff24268
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FRAS1 NELL2 PTPRK ALDH3B2

8.71e-05148704223d6a640f3c34e73646a615593b9c0b4a4cbd6f
ToppCellmild_COVID-19_(asymptomatic)-CD8+_T_naive|World / disease group, cell group and cell class (v2)

ZNF135 NELL2 RBAK SNX9

9.65e-05152704f944743f40ff6ed3a7a096dd53e12d3526c67c4d
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRAS1 CRISP1 SPOCK3 JAG1

1.12e-04158704d78e7e52657dc094430291fec07e9c298be9e584
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FRAS1 SCUBE1 PTPRK SHISA3

1.12e-04158704c8af8964a140acb2987e3b4906d72c546108d229
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABLIM1 FBLN2 TEK CRB2

1.18e-0416070433050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

STAB2 ZAN SLC6A20

1.22e-046170306aab3f1743ced1e46d22f0310f1cdb70c7a108e
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

STAB2 ZAN SLC6A20

1.22e-0461703fec6c9a4e12c260338856567bf547f914f473dbb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 JAG1 TEK NOTCH4

1.32e-04165704a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCellLV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

TRAF5 ACAN JAG1 NOTCH3

1.32e-04165704f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 TEK NOTCH4

1.36e-041667047a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 FBLN2 TEK NOTCH4

1.36e-04166704bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages|bone_marrow / Manually curated celltypes from each tissue

LRP1 SPINK6 NOTCH3 CRB2

1.42e-041687048ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

TPO FBLN2 TEK NOTCH4

1.42e-04168704aca34c51758c65925ad24110294a72b2dea6db72
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 JAG1 TEK NOTCH4

1.45e-04169704c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABLIM1 FBLN2 JAG1 NOTCH4

1.49e-0417070455fe16d98ea284d05fb899888e4569c685644c7b
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

SCUBE1 FBLN2 NOTCH4 SHISA3

1.52e-04171704c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCellAT1-AT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

FRAS1 FRMD6 ZNF112 NOTCH3

1.52e-041717040b9912f07393aca889db72b40da08e0bc9bc1e8c
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF5 ZNF146 SNX9 NSD3

1.52e-04171704c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCellLV-13._Vascular_Smooth_Muscle|LV / Chamber and Cluster_Paper

TRAF5 ACAN JAG1 NOTCH3

1.52e-04171704e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PRDM11 MEGF9 ZNF782 NOTCH4

1.55e-04172704a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFB2 PCSK5 FRAS1 NELL2

1.55e-04172704bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 NELL2 SPOCK3 CRB2

1.59e-04173704ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 NELL2 SPOCK3 CRB2

1.59e-041737043725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PCSK5 JAG1 TEK NOTCH4

1.59e-041737043a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPO OTOGL USH2A NOTCH3

1.62e-04174704f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN2 ACAN JAG1 NOTCH3

1.62e-04174704778e0317c0c63fa4efd74114feb760975b819d92
DrugGraveoline [485-61-0]; Up 200; 14.4uM; HL60; HT_HG-U133A

FZD1 ABLIM1 ZSCAN12 PTPRK ACAN JAG1 SLC6A20

2.64e-061997072179_UP
Drugcymene

PCSK5 IKZF5

9.32e-062702CID000010703
Drug4-methyl-2-phenyl-morpholin-2-ol

PRSS33 IKZF4

9.32e-062702CID000086194
Drugcis-linaloloxide

PCSK5 IKZF5

9.32e-062702CID000529304
Drugsodium hexametaphosphate

ZNF143 PRSS33 IKZF4

9.89e-0614703CID000024968
DrugKryptofix 222

PRSS33 IKZF4

2.79e-053702CID000072801
Drug4-methyl-3-nitroanisole

PRSS33 IKZF4

2.79e-053702CID000087137
Drug2-quinolinecarboxamide

PRSS33 IKZF4

2.79e-053702CID000145787
DrugTXIB

PRSS33 IKZF4

2.79e-053702CID000023284
DrugRU 52461

PRSS33 IKZF4

2.79e-053702CID000132349
DrugAC1L1S5M

PRSS33 IKZF4

2.79e-053702CID000009026
DrugSCH 40853

PRSS33 IKZF4

5.57e-054702CID003035575
Drugmethylmagnesium bromide

PRSS33 IKZF4

5.57e-054702CID000006349
Drug1,3-pentanediol

PRSS33 IKZF4

5.57e-054702CID000151085
DrugDL-menthyl acetate

PRSS33 IKZF4

5.57e-054702CID000027867
Drugcyclohexylmagnesium chloride

PRSS33 IKZF4

5.57e-054702CID000013605
DrugMuurola-4,9-diene

PCSK5 IKZF5

5.57e-054702CID000101708
Drugdipentylamine

PRSS33 IKZF4

5.57e-054702CID000016316
Drugacridine-4-carboxamide

PRSS33 IKZF4

5.57e-054702CID003025721
DrugAC1L9P74

PRSS33 IKZF4

9.26e-055702CID000450818
DrugWy 25093

PRSS33 IKZF4

9.26e-055702CID000175174
DrugSKF 82957

PRSS33 IKZF4

9.26e-055702CID000130844
Drugphosphorus tribromide

PRSS33 IKZF4

9.26e-055702CID000024614
Drug[11c]afa

PRSS33 IKZF4

9.26e-055702CID005352128
Drug[11c]afm

PRSS33 IKZF4

9.26e-055702CID005352125
Drug[11c]afe

PRSS33 IKZF4

9.26e-055702CID005732447
DrugWW781

PRSS33 IKZF4

1.39e-046702CID006439539
DrugNCQ 115

PRSS33 IKZF4

1.39e-046702CID000129499
DrugPittsburgh compound B

PRSS33 IKZF4

1.39e-046702CID002826731
DiseaseCarcinoma, Pancreatic Ductal

JAG1 NOTCH3 NOTCH4

2.09e-0524663C0887833
Diseaseaortic aneurysm

TGFB2 LRP1

2.19e-0410662EFO_0001666
DiseaseAlzheimer's disease (implicated_via_orthology)

LRP1 APLP2 NOTCH4

2.87e-0457663DOID:10652 (implicated_via_orthology)
DiseaseMigraine Disorders

LRP1 NOTCH3

3.78e-0413662C0149931
Diseasecomplement factor H-related protein 3 measurement

ACAN MTURN USH2A SHISA3

5.68e-04169664EFO_0600056
DiseaseEye Abnormalities

TGFB2 JAG1

6.56e-0417662C0015393
Diseaseserum IgG glycosylation measurement

TPO SCUBE1 PRDM11 STAB2 TEK USH2A

1.11e-03523666EFO_0005193
Diseasemacular telangiectasia type 2

SLC6A20 FBN3

1.55e-0326662EFO_1002009
DiseaseBone Diseases, Developmental

TGFB2 PCSK5

1.67e-0327662C0005941
Diseaseretinitis pigmentosa (implicated_via_orthology)

USH2A CRB2

1.67e-0327662DOID:10584 (implicated_via_orthology)
Diseasecolorectal cancer (implicated_via_orthology)

SNX9 NOTCH3

2.06e-0330662DOID:9256 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
DYQGLFGVKCEACHQ

ABLIM1

276

O14639
YFEGNAPDSCKVDGC

ALLC

281

Q8N6M5
HTGERPYCCDQCGKQ

GZF1

541

Q9H116
GGKNPCYVDDNCDPQ

ALDH3B2

131

P48448
GGHYCMDIDECQTPG

FBN3

566

Q75N90
YVCHYCHEGNDPETK

CRISP1

171

P54107
DPKYANQTCGLCGDF

MUC5B

196

Q9HC84
GVDQFHGTEYVCCPQ

APLP2

191

Q06481
GQCLSQCPDGYFHQE

FRAS1

741

Q86XX4
QCPDGYFHQEGSCTE

FRAS1

746

Q86XX4
QCVQECGKGYFADHA

FRAS1

1031

Q86XX4
NLDGGYDCRCPHGKN

NELL2

621

Q99435
FYVLCPDNGCGDNFH

MTURN

41

Q8N3F0
QDLPNGFQCHCPDGY

CRB2

336

Q5IJ48
HACENDQYGKPGGCS

LRP1

476

Q07954
CYQLPGCHGNFSDAE

FBLN2

171

P98095
EHFLYQGECGDSCPE

PCSK5

961

Q92824
NTKGGFQCLCADPYE

TPO

816

P07202
CRNGAKCVDQPDGYE

NOTCH3

516

Q9UM47
GNHCEECKEGFYQSP

MEGF9

326

Q9H1U4
CAGYPQGHKDACQGD

PRSS33

216

Q8NF86
HGYENPFQCNICGCK

IKZF5

386

Q9H5V7
PGYTGEHCNIDQEVC

ACAN

2306

P16112
LNYHFLGEKDCGAPC

FZD1

286

Q9UP38
FGCGHELDEEGLYCN

FRMD6

571

Q96NE9
DGNCHSQDYPGKYSE

CHD6

2036

Q8TD26
GQVDCGEFQDPKVYC

SPINK6

26

Q6UWN8
PHCGSDGQTYGNKCA

SPINK6

46

Q6UWN8
THCKNQHCGGELGDY

SCUBE1

791

Q8IWY4
DPFECNICGYHSQDR

IKZF4

556

Q9H2S9
AEGCNCPEGKFYEDT

OTOGL

776

Q3ZCN5
CTFDDGPGACDYHQD

PTPRK

36

Q15262
EGYSGPNCEIAEHAC

JAG1

326

P78504
DCNKGFTGTYCHENI

JAG1

616

P78504
NIHTGEKPYECNECG

ZNF146

176

Q15072
RCDQCKDHYFGFDPQ

USH2A

981

O75445
ECNHEYKGFLGCFPD

SNX9

491

Q9Y5X1
SYNICEDCEAGPYGH

NBR1

236

Q14596
ESCQEYFVDECPNHG

PRDM11

111

Q9NQV5
EGEVYCCKFHPNGST

SNRNP40

66

Q96DI7
GNYHEGFQCPEDFDT

SHISA3

36

A0PJX4
GYEGSNCELAKNECH

PROZ

116

P22891
CAPGYDGQNCSKELD

NOTCH4

956

Q99466
CPLNGNHTGYDEECE

SLC6A20

126

Q9NP91
PEAEQDCPFKHYGCA

TRAF5

216

O00463
HEPKGYNANFCAGAC

TGFB2

336

P61812
SEEKPYQCHQCGNAF

ZNF567

276

Q8N184
PYQCEHAGCGKAFAT

ZNF143

266

P52747
TGEKPYECNECGNAF

ZNF157

381

P51786
HTGEKPYECSECGNA

ZNF157

436

P51786
GESPYECHQCGKAFS

ZNF2

281

Q9BSG1
QHFQEPEVGCCGKYF

TSPAN17

6

Q96FV3
EKPYHCNECGENFSR

ZNF436

331

Q9C0F3
HTGEKPYECNQCGRA

ZNF135

516

P52742
QTHAEEKPYGCNECG

ZNF268

296

Q14587
TGENPYECHECGKAF

ZNF268

551

Q14587
HTGENPYECSECGKA

ZNF268

746

Q14587
NHSGERPYPCNECGK

RBAK

366

Q9NYW8
TGEKPYECNQCFHVF

ZNF558

231

Q96NG5
DPNDRCYECGEKGHY

SRSF7

101

Q16629
GHTGEKPYICNECGN

ZNF546

686

Q86UE3
ECKEHYQNFVPGVGC

STAB2

306

Q8WWQ8
LQCNEACHPGFYGPD

TEK

296

Q02763
PKQMHEDYCFQCGDG

NSD3

1316

Q9BZ95
CDEDGYYKPTQCHGS

SPOCK3

341

Q9BQ16
GENPYHCNEFGEAFI

ZNF841

561

Q6ZN19
CKCGEYGENFNHCSP

ZNF112

331

Q9UJU3
SGEEPYQCNECGKTF

ZNF397

476

Q8NF99
TGEKPYNCNQCGEAF

ZNF782

641

Q6ZMW2
PENLNGYCIHGKCEF

TMEFF1

276

Q8IYR6
GEGHYVCNQCGKAFG

ZNF557

281

Q8N988
TEEKPFHCPYCGNNF

ZNF382

291

Q96SR6
GVHTGAKPYECNECG

ZSCAN12

406

O43309
IHSGENPYECFECGK

ZNF805

336

Q5CZA5
GEKPYECNECGEAFS

ZFP90

521

Q8TF47
GDTGHKACECQEYGP

ZNF439

141

Q8NDP4
CGEGFPQCDFEDNAH

ZAN

366

Q9Y493