Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dicarboxylic acid transmembrane transporter activity	SLC26A8 SLC25A21 SLC16A1 SLC26A7	7.64e-06	31	82	4	GO:0005310
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1 NCF1C NCF1B	7.85e-06	10	82	3	GO:0016176
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1 NCF1C NCF1B	1.43e-05	12	82	3	GO:0016175
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	NCF1 NCF1C NCF1B	7.24e-05	20	82	3	GO:0050664
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	NCF1 NCF1C NCF1B	3.97e-04	35	82	3	GO:0043325
GeneOntologyMolecularFunction	oxalate transmembrane transporter activity	SLC26A8 SLC26A7	7.34e-04	10	82	2	GO:0019531
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC26A8 SLC25A21 ATP6V0D1 SLC16A1 SLC26A7 ABCA13 BCS1L ANKH	7.59e-04	477	82	8	GO:0022804
GeneOntologyBiologicalProcess	neutrophil-mediated killing of gram-positive bacterium	NCF1 NCF1C NCF1B	5.80e-07	5	81	3	GO:0070946
GeneOntologyBiologicalProcess	NADP catabolic process	NCF1 NCF1C NCF1B	2.02e-06	7	81	3	GO:0006742
GeneOntologyBiologicalProcess	neutrophil-mediated killing of fungus	NCF1 NCF1C NCF1B	2.02e-06	7	81	3	GO:0070947
GeneOntologyBiologicalProcess	regulation of respiratory burst involved in inflammatory response	NCF1 NCF1C NCF1B	9.41e-06	11	81	3	GO:0060264
GeneOntologyBiologicalProcess	respiratory burst involved in inflammatory response	NCF1 NCF1C NCF1B	1.62e-05	13	81	3	GO:0002536
GeneOntologyBiologicalProcess	neutrophil-mediated killing of bacterium	NCF1 NCF1C NCF1B	3.15e-05	16	81	3	GO:0070944
GeneOntologyBiologicalProcess	response to yeast	NCF1 NCF1C NCF1B	4.56e-05	18	81	3	GO:0001878
GeneOntologyBiologicalProcess	neutrophil-mediated killing of symbiont cell	NCF1 NCF1C NCF1B	5.40e-05	19	81	3	GO:0070943
GeneOntologyBiologicalProcess	respiratory burst involved in defense response	NCF1 NCF1C NCF1B	6.34e-05	20	81	3	GO:0002679
GeneOntologyBiologicalProcess	neutrophil mediated cytotoxicity	NCF1 NCF1C NCF1B	7.37e-05	21	81	3	GO:0070942
GeneOntologyBiologicalProcess	negative regulation of smooth muscle contraction	NCF1 NCF1C NCF1B	8.51e-05	22	81	3	GO:0045986
GeneOntologyBiologicalProcess	hydrogen peroxide biosynthetic process	NCF1 NCF1C NCF1B	8.51e-05	22	81	3	GO:0050665
GeneOntologyBiologicalProcess	regulation of respiratory burst	NCF1 NCF1C NCF1B	9.76e-05	23	81	3	GO:0060263
GeneOntologyBiologicalProcess	regulation of immune effector process	HSPD1 DPP4 FCGR1A NCF1 CD46 NCF1C PGC NCF1B PCK1	1.43e-04	497	81	9	GO:0002697
GeneOntologyBiologicalProcess	regulation of smooth muscle contraction	NCF1 NCF1C NCF1B CHRNB4	2.65e-04	79	81	4	GO:0006940
GeneOntologyBiologicalProcess	reactive oxygen species biosynthetic process	HSPD1 NCF1 NCF1C NCF1B	2.78e-04	80	81	4	GO:1903409
GeneOntologyBiologicalProcess	regulation of cholesterol biosynthetic process	CYP7A1 LPCAT3 DHCR7	2.92e-04	33	81	3	GO:0045540
GeneOntologyBiologicalProcess	regulation of sterol biosynthetic process	CYP7A1 LPCAT3 DHCR7	2.92e-04	33	81	3	GO:0106118
GeneOntologyBiologicalProcess	negative regulation of muscle contraction	NCF1 NCF1C NCF1B	3.49e-04	35	81	3	GO:0045932
GeneOntologyBiologicalProcess	killing by host of symbiont cells	NCF1 NCF1C NCF1B	4.46e-04	38	81	3	GO:0051873
GeneOntologyBiologicalProcess	cholesterol metabolic process	CYP7A1 LPCAT3 DHCR7 LEPR PCTP	4.58e-04	163	81	5	GO:0008203
GeneOntologyBiologicalProcess	positive regulation of memory T cell differentiation	CD46 PCK1	5.39e-04	9	81	2	GO:0043382
GeneOntologyBiologicalProcess	leukotriene metabolic process	NCF1 NCF1C NCF1B	5.59e-04	41	81	3	GO:0006691
GeneOntologyCellularComponent	NADPH oxidase complex	NCF1 NCF1C NCF1B	4.55e-05	18	82	3	GO:0043020
MousePheno	abnormal angiotensin I-converting enzyme activity	NCF1 NCF1C NCF1B	2.59e-06	6	72	3	MP:0013254
MousePheno	increased angiotensin I-converting enzyme activity	NCF1 NCF1C NCF1B	2.59e-06	6	72	3	MP:0003184
MousePheno	liver abscess	NCF1 NCF1C NCF1B	4.52e-06	7	72	3	MP:0003332
MousePheno	impaired granulocyte bactericidal activity	NCF1 NCF1C NCF1B	1.53e-05	10	72	3	MP:0005074
MousePheno	decreased lipid level	SLC25A21 SLC16A1 PREP LPCAT3 DHCR7 NCF1 G6PC2 GRHL3 NCF1C NCF1B LEPR PCK1 PCTP	7.53e-05	727	72	13	MP:0014461
MousePheno	abnormal vascular smooth muscle physiology	TIMP3 NCF1 HHIPL1 NCF1C NCF1B LEPR	8.23e-05	140	72	6	MP:0005595
MousePheno	decreased susceptibility to Orthomyxoviridae infection	NCF1 NCF1C NCF1B	1.01e-04	18	72	3	MP:0020947
MousePheno	skin lesions	NCF1 GRHL3 NCF1C NCF1B B4GALT1	1.04e-04	91	72	5	MP:0001212
MousePheno	abnormal vasoconstriction	NCF1 NCF1C NCF1B LEPR	1.25e-04	50	72	4	MP:0000250
MousePheno	abnormal blood vessel physiology	DPP4 TIMP3 NCF1 CD46 HHIPL1 NCF1C NCF1B KAT14 LEPR	1.81e-04	394	72	9	MP:0000249
MousePheno	decreased vasoconstriction	NCF1 NCF1C NCF1B	1.88e-04	22	72	3	MP:0003026
MousePheno	increased circulating renin level	NCF1 NCF1C NCF1B	2.15e-04	23	72	3	MP:0003352
MousePheno	abnormal vasculature physiology	DPP4 TIMP3 NCF1 CD46 HHIPL1 NCF1C NCF1B KAT14 LEPR	2.19e-04	404	72	9	MP:0031170
MousePheno	abnormal locomotor activation	NCF1 GRHL3 NCF1C NCF1B LEPR	2.75e-04	112	72	5	MP:0003313
Domain	Peptidase_S9	DPP4 PREP DPP8	1.13e-05	11	78	3	PF00326
Domain	Peptidase_S9	DPP4 PREP DPP8	1.13e-05	11	78	3	IPR001375
Domain	Pept_S9_AS	DPP4 PREP	1.03e-04	4	78	2	IPR002471
Domain	PRO_ENDOPEP_SER	DPP4 PREP	1.71e-04	5	78	2	PS00708
Domain	-	DPP4 DPP8	2.55e-04	6	78	2	2.140.10.30
Domain	DPPIV_N	DPP4 DPP8	2.55e-04	6	78	2	PF00930
Domain	CP2	GRHL1 GRHL3	2.55e-04	6	78	2	PF04516
Domain	CP2	GRHL1 GRHL3	2.55e-04	6	78	2	IPR007604
Domain	Peptidase_S9B_N	DPP4 DPP8	2.55e-04	6	78	2	IPR002469
Domain	SLC26A	SLC26A8 SLC26A7	7.58e-04	10	78	2	PS01130
Domain	STAS	SLC26A8 SLC26A7	9.24e-04	11	78	2	PS50801
Domain	STAS_dom	SLC26A8 SLC26A7	9.24e-04	11	78	2	IPR002645
Domain	SLC26A/SulP_dom	SLC26A8 SLC26A7	9.24e-04	11	78	2	IPR011547
Domain	STAS	SLC26A8 SLC26A7	9.24e-04	11	78	2	PF01740
Domain	SLC26A/SulP_fam	SLC26A8 SLC26A7	9.24e-04	11	78	2	IPR001902
Domain	-	SLC26A8 SLC26A7	9.24e-04	11	78	2	3.30.750.24
Domain	Sulfate_transp	SLC26A8 SLC26A7	9.24e-04	11	78	2	PF00916
Domain	-	DPP4 PREP DPP8 NDRG3	1.55e-03	119	78	4	3.40.50.1820
Domain	AB_hydrolase	DPP4 PREP DPP8 NDRG3	1.55e-03	119	78	4	IPR029058
Domain	MAM_1	PTPRK MDGA2	1.99e-03	16	78	2	PS00740
Domain	MAM	PTPRK MDGA2	2.25e-03	17	78	2	SM00137
Domain	MAM	PTPRK MDGA2	2.52e-03	18	78	2	PF00629
Domain	MAM_dom	PTPRK MDGA2	2.52e-03	18	78	2	IPR000998
Domain	MAM_2	PTPRK MDGA2	2.52e-03	18	78	2	PS50060
Domain	EPHD	TCF20 KDM4A	3.77e-03	22	78	2	PS51805
Domain	-	CNOT6 ANGEL1	5.24e-03	26	78	2	3.60.10.10
Domain	TIMP-like_OB-fold	TIMP3 C17orf58	5.24e-03	26	78	2	IPR008993
Domain	Exo_endo_phos	CNOT6 ANGEL1	5.24e-03	26	78	2	PF03372
Domain	Endo/exonuclease/phosphatase	CNOT6 ANGEL1	5.65e-03	27	78	2	IPR005135
Domain	PHD	TCF20 KDM4A CXXC1	6.15e-03	89	78	3	SM00249
Domain	Znf_PHD	TCF20 KDM4A CXXC1	6.54e-03	91	78	3	IPR001965
Domain	ZF_PHD_2	TCF20 KDM4A CXXC1	7.36e-03	95	78	3	PS50016
Domain	ZF_PHD_1	TCF20 KDM4A CXXC1	7.58e-03	96	78	3	PS01359
Pathway	REACTOME_IRE1ALPHA_ACTIVATES_CHAPERONES	ATP6V0D1 ZBTB17 TATDN2 EXTL2 CXXC1	1.67e-06	50	57	5	M27282
Pathway	REACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES	NCF1 NCF1C NCF1B	5.18e-06	9	57	3	MM14524
Pathway	REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES	ATP6V0D1 NCF1 NCF1C NCF1B	1.60e-05	38	57	4	MM14519
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	FCGR1A NCF1 NCF1C NCF1B	3.45e-05	46	57	4	MM15837
Pathway	REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR	ATP6V0D1 ZBTB17 TATDN2 EXTL2 CXXC1	3.58e-05	93	57	5	M10294
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	NCF1 NCF1C NCF1B	1.35e-04	25	57	3	MM15269
Pathway	REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION	FCGR1A NCF1 NCF1C NCF1B	2.48e-04	76	57	4	MM14526
Pathway	BIOCARTA_FMLP_PATHWAY	NCF1 NCF1C NCF1B	3.43e-04	34	57	3	MM1399
Pathway	REACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES	NCF1 NCF1C NCF1B	3.74e-04	35	57	3	MM14944
Pathway	REACTOME_INNATE_IMMUNE_SYSTEM	ATP6V0D1 FCGR1A ABCA13 CSNK2B NCF1 TMEM30A CD46 NCF1C NCF1B DYNC1H1 CHRNB4 B4GALT1	5.22e-04	995	57	12	MM14661
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	27044504
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	18787174
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	22184329
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20142487
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	39357591
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	31118934
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	16041040
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	18703411
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	17307863
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	27829407
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	28274989
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	12364355
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10670582
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20864666
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	23328631
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	17114280
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	25989352
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	36592568
Pubmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	30504842
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	33705493
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	23965970
Pubmed	Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	15513930
Pubmed	Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	15033459
Pubmed	Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20828610
Pubmed	p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20817944
Pubmed	NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	36853827
Pubmed	Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	23024271
Pubmed	Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	21253614
Pubmed	Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	15310853
Pubmed	Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	31393787
Pubmed	Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10725280
Pubmed	Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	34970267
Pubmed	Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	25689796
Pubmed	Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	14993144
Pubmed	Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	22050439
Pubmed	The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	12031896
Pubmed	NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	11249873
Pubmed	Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	15936744
Pubmed	NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	25628043
Pubmed	Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	12560337
Pubmed	Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	35276443
Pubmed	Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	19381132
Pubmed	Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47 degrees chronic granulomatous disease carrier detection.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	12176908
Pubmed	A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	9329953
Pubmed	Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10799876
Pubmed	Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	11834706
Pubmed	A model of chronic enthesitis and new bone formation characterized by multimodal imaging.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	30045841
Pubmed	Virulence and cellular interactions of Burkholderia multivorans in chronic granulomatous disease.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	19635825
Pubmed	The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	35788118
Pubmed	Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	17310103
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10678931
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10891396
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	25474113
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	26209274
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	11018074
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	21570954
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	12958309
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	23482812
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	21435178
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	29228045
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	22155727
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	24576409
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	26645958
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	24549323
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20881184
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	19168575
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	19503084
Pubmed	Genetic requirement of p47phox for superoxide production by murine microglia.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	11156938
Pubmed	Genomic structure of the human p47-phox (NCF1) gene.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	10772875
Pubmed	A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	27798190
Pubmed	Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20702812
Pubmed	Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	26455429
Pubmed	Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	15626477
Pubmed	NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	19077231
Pubmed	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	22319452
Pubmed	Early determinants of H2O2-induced endothelial dysfunction.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	16895801
Pubmed	Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	20690191
Pubmed	Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	16772302
Pubmed	Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	32504071
Pubmed	Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.	NCF1 NCF1C NCF1B	1.31e-08	3	83	3	16280459
Cytoband	6q22	PREP DSE	8.98e-05	8	83	2	6q22
Cytoband	2q24.3	DPP4 G6PC2	3.81e-04	16	83	2	2q24.3
Cytoband	7q11.23	NCF1 NCF1C NCF1B	7.43e-04	97	83	3	7q11.23
GeneFamily	CD molecules\|DASH family	DPP4 DPP8	1.26e-04	7	45	2	1205
GeneFamily	Immunoglobulin like domain containing	FCGR1A PTPRK MDGA2 LEPR	1.33e-03	193	45	4	594
GeneFamily	Solute carriers	SLC26A8 SLC25A21 SLC16A1 SLC26A7 SLC7A14	2.89e-03	395	45	5	752
Coexpression	GSE26669_CD4_VS_CD8_TCELL_IN_MLR_UP	GRHL1 TIMP3 PARP2 CAPG NDRG3 ANKH SLC7A14	3.18e-06	200	82	7	M4668
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ATP6V0D1 FCGR1A EGR2 CAPG NCF1 DSE	1.84e-06	199	82	6	8a7bccf76fdf0b46854750a0a6a5eade0e14e515
Drug	Gly-pro-mca	DPP4 PREP DPP8	1.25e-05	13	82	3	CID000125640
Drug	7-dehydrocholesterol	CYP7A1 DHCR7	1.28e-05	2	82	2	ctd:C016705
Drug	vildagliptin	DPP4 DPP8	1.28e-05	2	82	2	ctd:C502012
Drug	(2S,5S)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile	DPP4 DPP8	1.28e-05	2	82	2	CID010263908
Drug	1,1'-Carbonyl-di-(1,2,4-triazole)	HSPD1 TCF20 ENPP2 PMM2	1.29e-05	40	82	4	CID004393961
Drug	acridine orange	HSPD1 CSNK2B KYAT1	2.44e-05	16	82	3	CID000062344
Drug	dAbs	ADPRH GRHL1 ENPP2 CSNK2B	2.70e-05	48	82	4	CID000067539
Drug	SureCN3749646	DPP4 DPP8	3.84e-05	3	82	2	CID011530920
Drug	SureCN3745540	DPP4 DPP8	3.84e-05	3	82	2	CID011974437
Drug	SureCN3749947	DPP4 DPP8	3.84e-05	3	82	2	CID011974435
Drug	ABT-279	DPP4 DPP8	3.84e-05	3	82	2	CID016049769
Drug	Cyanopyrrolidine 38	DPP4 DPP8	3.84e-05	3	82	2	CID010932707
Drug	Cyanopyrrolidine 39	DPP4 DPP8	3.84e-05	3	82	2	CID011117606
Drug	SureCN3748611	DPP4 DPP8	3.84e-05	3	82	2	CID011974325
Drug	Diprolyl-alanine	DPP4 DPP8	3.84e-05	3	82	2	CID000193559
Drug	dichlobenil	GRHL3 BCS1L KYAT1	5.71e-05	21	82	3	CID000003031
Drug	malachite green	HSPD1 TCF20 G6PC2	6.60e-05	22	82	3	CID000011294
Drug	glycylproline 4-nitroanilide	DPP4 DPP8	7.65e-05	4	82	2	ctd:C042892
Drug	Piretanide [55837-27-9]; Up 200; 11uM; MCF7; HT_HG-U133A	ZBTB17 MYOZ1 TIMP3 LPCAT3 TEX14 LEPR	8.34e-05	199	82	6	6828_UP
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1 NCF1C NCF1B	1.98e-07	5	81	3	DOID:3265 (implicated_via_orthology)
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1 NCF1C NCF1B	4.31e-06	12	81	3	DOID:7148 (implicated_via_orthology)
Disease	congenital disorder of glycosylation (is_implicated_in)	B4GALT1 PMM2	7.44e-06	2	81	2	DOID:5212 (is_implicated_in)
Disease	non-alcoholic steatohepatitis (biomarker_via_orthology)	CYP7A1 PCK1	9.85e-04	17	81	2	DOID:0080547 (biomarker_via_orthology)
Disease	arginine measurement	FOXQ1 PYROXD2	1.81e-03	23	81	2	EFO_0020990
Disease	triglyceride measurement, response to escitalopram, response to citalopram	CNOT6 FGF4	2.50e-03	27	81	2	EFO_0004530, EFO_0006329, EFO_0007871
Disease	opioid use disorder	DPP4 TCF20 KDM4A	2.74e-03	101	81	3	EFO_0010702

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPNMYYTFGKDFKQN	ZNF354C	186	Q86Y25
NFYGNSMYFVNPASA	CHRNB4	381	P30926
VAMDKFGFSLPYVQY	B4GALT1	271	P15291
FYEISQIFYGKNMPC	CFAP54	2131	Q96N23
EGTAFNVTMGYKYPP	ERVK11-1	16	P61568
GYKYFSGKNVLMPSS	CXorf58	126	Q96LI9
NLNGKSQYYIMFGPD	CALR3	121	Q96L12
VQGYFMLYKNDPVGA	BCS1L	396	Q9Y276
FPFKNYRQAGGDYAM	GVINP1	2351	Q7Z2Y8
MASPKGFFNYLTYFL	C1orf185	1	Q5T7R7
DGFKYNYVFAPLQDM	ABCA13	3516	Q86UQ4
GMKFDRGYISPYFIN	HSPD1	216	P10809
FYNYMMGIEFNPRIG	DHCR7	216	Q9UBM7
AMRPFFGYNFGKYLA	PCK1	481	P35558
TYMGKFSIDPQYPGA	EGR2	91	P11161
PITGYMFGKGIYFAD	PARP2	451	Q9UGN5
FNLNPALTMIGKYFY	SLC16A1	126	P53985
FKYFLQGMGYIPSAS	NDRG3	306	Q9UGV2
YFGFYYNVKNMIPVN	SLC25A21	186	Q9BQT8
FYGTANMTYLQPKSG	OR10A3	251	P58181
VPANGTYEFGYQMHF	CD46	111	P15529
YPNLNGLYIFGDFMS	HHIPL1	486	Q96JK4
YKMNRLYLTPDGFFF	C17orf58	241	Q2M2W7
YSNIMISQFGFPYAN	EXTL2	311	Q9UBQ6
FGSFDQTMKGNSYLP	FSIP2	3251	Q5CZC0
EKPYLFSLGYDSNMG	PCNX4	1076	Q63HM2
SYKYPGMFIALSKNG	FGF4	171	P08620
VTGYFPSMYLQKSGQ	NCF1	271	P14598
AFGFMVPDVKYNEAY	KAT14	686	Q9H8E8
EFMITFPYGYHAGFN	KDM4A	266	O75164
SYFYGAFLVGPQFSM	LPCAT3	191	Q6P1A2
ALYGPKYTFFNNVLM	DSE	471	Q9UL01
KYQFSLYPIFMEGVG	LEPR	806	P48357
YYISNEYKGMPGGRN	DPP4	416	P27487
TMQKAAYYENPGLFG	HOXD3	16	P31249
AFAKSQPNMYGLAAY	HOXD3	301	P31249
DVTGYFPSMYLQKSG	NCF1B	271	A6NI72
DVTGYFPSMYLQKSG	NCF1C	246	A8MVU1
PNADRSGSKEGFYMY	MDGA2	786	Q7Z553
DGKGMFYNSYPQQDG	PREP	181	P48147
VFMYYFDNPGGQIPS	PCTP	171	Q9UKL6
YAKYESQTSFGSMYP	CXXC1	506	Q9P0U4
YFFLGMYKQAEAAGF	TTC26	101	A0AVF1
GESPMAYLNKGQFYP	GRHL3	246	Q8TE85
PGDSTMTYLNKGQFY	GRHL1	266	Q9NZI5
YYLGSVAMQAEKFPS	DPP8	806	Q6V1X1
SYGLAYSLMKFFTGP	ANKH	51	Q9HCJ1
QMLEKYQQGDFGYCP	CSNK2B	96	P67870
AYYTFLNFMSNVGDP	G6PC2	21	Q9NQR9
EKSFEGNVFMYYGLS	TMEM30A	111	Q9NV96
PGLQLYFSFYMGSKT	FCGR1A	221	P12314
MANAKFNYGFEYLGV	DYNC1H1	1861	Q14204
FMSYFPRGLKYQEGG	CAPG	106	P40121
NGLKLKYYYMPFGSG	CYP7A1	426	P22680
YLYKDGEMIPYGFNN	IGFN1	246	Q86VF2
LMPYTNYTFDFKGII	CNOT6	476	Q9ULM6
KNDKQMSYGFLFPPY	ENPP2	671	Q13822
PFYMGFIPAMQDNYA	FAM166A	281	Q6J272
NEYLMGKFPFFRGSY	FOXQ1	146	Q9C009
LYMGQIKGAFGTYEP	MS4A13	16	Q5J8X5
VTYQNAMSGGAPYYF	PTPRK	656	Q15262
YKTIYFFGDKTMPGG	PMM2	201	O15305
GEYNIFKYAPMFESN	GARIN3	36	Q8TC56
GVVLFTMLYGQFPFY	STK40	261	Q8N2I9
KSGMYEYYASEGQNP	SMCHD1	126	A6NHR9
PKAVAFGEMGLDYSY	TATDN2	586	Q93075
SAQNIYSFGFGKAMP	TEX14	201	Q8IWB6
EFSAPSYLMGYNKSL	SLC26A8	181	Q96RN1
GDFMLNQYTKTFGYP	KYAT1	56	Q16773
GPGSLDTFMQYFYGQ	TEX45	321	Q8NA69
DQGFQFSYKEMLIGY	MROH2B	771	Q7Z745
FYGTLIFMYLQPKSN	OR8U3	251	Q8NH85
VMYGFKGVSPSNYEK	ADPRH	316	P54922
KAGDGPQFQFTLMSY	ANGEL1	236	Q9UNK9
TAFFMYNAFGKPFET	CLRN1	116	P58418
KPAITYGTRGNSYFM	CNDP1	236	Q96KN2
FFYPNMGGVESHIYQ	PIGA	41	P37287
GGPTEDKGFYYQQMS	SLC7A14	721	Q8TBB6
FVYAQFDGIMGLAYP	PGC	171	P20142
VFKVSLVSGMPFYGY	REV3L	101	O60673
LFTQYMPYTLAGGKA	PYROXD2	456	Q8N2H3
AGDFYYMAGNKDPVT	TCF20	86	Q9UGU0
MFQTDADFYQQYGPG	ZBTB17	746	Q13105
AMTYYGNLDSEKPIF	SLC26A7	616	Q8TE54
TDMLSNFGYPGYQSK	TIMP3	166	P35625
MSFFPELYFNVDNGY	ATP6V0D1	1	P61421
FNRTAMPYGGYEKAS	MYOZ1	221	Q9NP98