Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	3.53e-06	2	38	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	3.53e-06	2	38	2	GO:0047783
GeneOntologyMolecularFunction	PDZ domain binding	DOCK4 CFTR EXOC4 CASK	8.61e-05	123	38	4	GO:0030165
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	2.71e-04	13	38	2	GO:0016713
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	1.87e-05	4	37	2	GO:0002017
GeneOntologyBiologicalProcess	oligodendrocyte differentiation	SOX6 NEUROD4 TLR2 EXOC4	1.04e-04	137	37	4	GO:0048709
GeneOntologyBiologicalProcess	cortisol biosynthetic process	CYP11B1 CYP11B2	1.40e-04	10	37	2	GO:0034651
GeneOntologyBiologicalProcess	tertiary alcohol biosynthetic process	CYP11B1 CYP11B2	1.40e-04	10	37	2	GO:1902645
GeneOntologyBiologicalProcess	aldosterone biosynthetic process	CYP11B1 CYP11B2	1.70e-04	11	37	2	GO:0032342
GeneOntologyBiologicalProcess	cell differentiation in spinal cord	SOX6 PAX3 PAX7	1.96e-04	63	37	3	GO:0021515
GeneOntologyBiologicalProcess	cholesterol metabolic process	CUBN CYP11B1 CYP11B2 CFTR	2.03e-04	163	37	4	GO:0008203
GeneOntologyBiologicalProcess	cortisol metabolic process	CYP11B1 CYP11B2	2.04e-04	12	37	2	GO:0034650
GeneOntologyBiologicalProcess	mineralocorticoid biosynthetic process	CYP11B1 CYP11B2	2.41e-04	13	37	2	GO:0006705
GeneOntologyBiologicalProcess	male gonad development	ASPM KDR NUP210L CFTR	2.43e-04	171	37	4	GO:0008584
GeneOntologyBiologicalProcess	development of primary male sexual characteristics	ASPM KDR NUP210L CFTR	2.49e-04	172	37	4	GO:0046546
GeneOntologyBiologicalProcess	secondary alcohol metabolic process	CUBN CYP11B1 CYP11B2 CFTR	2.72e-04	176	37	4	GO:1902652
GeneOntologyBiologicalProcess	sterol metabolic process	CUBN CYP11B1 CYP11B2 CFTR	2.77e-04	177	37	4	GO:0016125
GeneOntologyBiologicalProcess	primary alcohol biosynthetic process	CYP11B1 CYP11B2	2.81e-04	14	37	2	GO:0034309
GeneOntologyBiologicalProcess	spinal cord association neuron differentiation	PAX3 PAX7	2.81e-04	14	37	2	GO:0021527
GeneOntologyBiologicalProcess	aldosterone metabolic process	CYP11B1 CYP11B2	2.81e-04	14	37	2	GO:0032341
GeneOntologyBiologicalProcess	positive regulation of stem cell proliferation	KDR CITED1 PAX3	2.91e-04	72	37	3	GO:2000648
GeneOntologyBiologicalProcess	animal organ morphogenesis	SOX6 KDR CITED1 PAX3 PAX7 GZF1 SERPINH1 CFTR EXOC4	3.18e-04	1269	37	9	GO:0009887
GeneOntologyBiologicalProcess	cell fate commitment	SOX6 KDR PAX3 PAX7 NEUROD4	3.25e-04	338	37	5	GO:0045165
GeneOntologyBiologicalProcess	mineralocorticoid metabolic process	CYP11B1 CYP11B2	4.19e-04	17	37	2	GO:0008212
GeneOntologyBiologicalProcess	male sex differentiation	ASPM KDR NUP210L CFTR	4.33e-04	199	37	4	GO:0046661
GeneOntologyBiologicalProcess	drinking behavior	CYP11B1 CYP11B2	4.70e-04	18	37	2	GO:0042756
GeneOntologyBiologicalProcess	glucocorticoid biosynthetic process	CYP11B1 CYP11B2	4.70e-04	18	37	2	GO:0006704
GeneOntologyBiologicalProcess	renal system process involved in regulation of blood volume	CYP11B1 CYP11B2	4.70e-04	18	37	2	GO:0001977
GeneOntologyBiologicalProcess	multicellular organismal-level chemical homeostasis	KDR CYP11B2 CFTR	5.61e-04	90	37	3	GO:0140962
GeneOntologyBiologicalProcess	response to cAMP	PTK2B CITED1 CFTR	6.98e-04	97	37	3	GO:0051591
GeneOntologyBiologicalProcess	dorsal spinal cord development	PAX3 PAX7	7.07e-04	22	37	2	GO:0021516
GeneOntologyBiologicalProcess	tertiary alcohol metabolic process	CYP11B1 CYP11B2	7.07e-04	22	37	2	GO:1902644
GeneOntologyBiologicalProcess	peptidyl-tyrosine autophosphorylation	PTK2B KDR	7.07e-04	22	37	2	GO:0038083
GeneOntologyBiologicalProcess	negative regulation of bone mineralization	PTK2B ECM1	7.74e-04	23	37	2	GO:0030502
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	CYP11B1 CYP11B2	7.74e-04	23	37	2	GO:0001991
GeneOntologyBiologicalProcess	Sertoli cell development	NUP210L CFTR	8.43e-04	24	37	2	GO:0060009
GeneOntologyBiologicalProcess	cartilage development	SOX6 PAX7 ECM1 SERPINH1	9.15e-04	243	37	4	GO:0051216
GeneOntologyBiologicalProcess	C21-steroid hormone biosynthetic process	CYP11B1 CYP11B2	9.90e-04	26	37	2	GO:0006700
GeneOntologyBiologicalProcess	gliogenesis	SOX6 PTK2B NEUROD4 TLR2 EXOC4	1.02e-03	435	37	5	GO:0042063
GeneOntologyBiologicalProcess	glucocorticoid metabolic process	CYP11B1 CYP11B2	1.07e-03	27	37	2	GO:0008211
GeneOntologyBiologicalProcess	central nervous system development	ASPM SOX6 CITED1 PAX3 PAX7 NEUROD4 TLR2 EXOC4	1.07e-03	1197	37	8	GO:0007417
GeneOntologyBiologicalProcess	regulation of biomineral tissue development	PTK2B ECM1 CFTR	1.11e-03	114	37	3	GO:0070167
GeneOntologyBiologicalProcess	positive regulation of systemic arterial blood pressure	CYP11B1 CYP11B2	1.15e-03	28	37	2	GO:0003084
GeneOntologyBiologicalProcess	spinal cord development	SOX6 PAX3 PAX7	1.26e-03	119	37	3	GO:0021510
GeneOntologyBiologicalProcess	regulation of stem cell proliferation	KDR CITED1 PAX3	1.26e-03	119	37	3	GO:0072091
GeneOntologyBiologicalProcess	aldehyde biosynthetic process	CYP11B1 CYP11B2	1.41e-03	31	37	2	GO:0046184
GeneOntologyBiologicalProcess	renal system process involved in regulation of systemic arterial blood pressure	CYP11B1 CYP11B2	1.41e-03	31	37	2	GO:0003071
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure	KDR CYP11B1 CYP11B2	1.42e-03	124	37	3	GO:0003073
GeneOntologyBiologicalProcess	organic hydroxy compound biosynthetic process	CITED1 CYP11B1 CYP11B2 CFTR	1.48e-03	277	37	4	GO:1901617
GeneOntologyBiologicalProcess	negative regulation of biomineral tissue development	PTK2B ECM1	1.50e-03	32	37	2	GO:0070168
GeneOntologyBiologicalProcess	Sertoli cell differentiation	NUP210L CFTR	1.60e-03	33	37	2	GO:0060008
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	PTK2B KDR PLCB2 CYP11B1 CYP11B2 CFTR	1.60e-03	717	37	6	GO:0050801
GeneOntologyBiologicalProcess	chondrocyte differentiation	SOX6 ECM1 SERPINH1	1.73e-03	133	37	3	GO:0002062
GeneOntologyBiologicalProcess	multicellular organismal-level water homeostasis	CYP11B2 CFTR	1.79e-03	35	37	2	GO:0050891
GeneOntologyBiologicalProcess	olefinic compound biosynthetic process	CYP11B1 CYP11B2	1.79e-03	35	37	2	GO:0120255
GeneOntologyBiologicalProcess	gonad development	ASPM KDR NUP210L CFTR	1.80e-03	292	37	4	GO:0008406
MousePheno	increased circulating adrenocorticotropin level	CYP11B1 CYP11B2 TLR2	3.54e-06	14	31	3	MP:0001748
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	4.76e-06	2	31	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	4.76e-06	2	31	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	4.76e-06	2	31	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	4.76e-06	2	31	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	4.76e-06	2	31	2	MP:0011546
MousePheno	increased adrenocorticotropin level	CYP11B1 CYP11B2 TLR2	1.48e-05	22	31	3	MP:0005129
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	2.85e-05	4	31	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	2.85e-05	4	31	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	2.85e-05	4	31	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	2.85e-05	4	31	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	2.85e-05	4	31	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	4.74e-05	5	31	2	MP:0014286
MousePheno	enlarged adrenal glands	CYP11B1 CYP11B2 TLR2	5.64e-05	34	31	3	MP:0000642
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	7.10e-05	6	31	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	7.10e-05	6	31	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	7.10e-05	6	31	2	MP:0009078
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	9.93e-05	7	31	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	9.93e-05	7	31	2	MP:0000635
MousePheno	abnormal adrenocorticotropin level	CYP11B1 CYP11B2 TLR2	9.94e-05	41	31	3	MP:0003966
MousePheno	abnormal adrenal cortex morphology	CYP11B1 CYP11B2 TLR2	1.07e-04	42	31	3	MP:0008288
MousePheno	decreased circulating corticosterone level	CYP11B1 CYP11B2 TLR2	1.15e-04	43	31	3	MP:0002665
MousePheno	decreased circulating glucocorticoid level	CYP11B1 CYP11B2 TLR2	1.23e-04	44	31	3	MP:0003368
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	1.32e-04	8	31	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	1.32e-04	8	31	2	MP:0031229
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	2.12e-04	10	31	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	2.12e-04	10	31	2	MP:0008291
MousePheno	pointed snout	PAX7 CASK	2.12e-04	10	31	2	MP:0000448
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2	2.59e-04	11	31	2	MP:0014284
MousePheno	uterus cyst	CYP11B1 CYP11B2	2.59e-04	11	31	2	MP:0009082
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2	3.10e-04	12	31	2	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2	3.10e-04	12	31	2	MP:0031227
MousePheno	hypokalemia	CYP11B1 CYP11B2	3.10e-04	12	31	2	MP:0004119
MousePheno	enlarged pituitary gland	CYP11B1 CYP11B2	3.10e-04	12	31	2	MP:0000636
MousePheno	increased renin activity	CYP11B1 CYP11B2	4.26e-04	14	31	2	MP:0005582
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2	4.26e-04	14	31	2	MP:0003374
MousePheno	increased urine osmolality	CYP11B1 CYP11B2	4.26e-04	14	31	2	MP:0008055
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2	4.26e-04	14	31	2	MP:0002667
MousePheno	endometrium hyperplasia	CYP11B1 CYP11B2	4.26e-04	14	31	2	MP:0009092
MousePheno	abnormal uterus size	DOCK4 CYP11B1 CYP11B2 CFTR	4.92e-04	168	31	4	MP:0004902
MousePheno	enlarged uterus	DOCK4 CYP11B1 CYP11B2	6.22e-04	76	31	3	MP:0004906
MousePheno	abnormal adrenal gland zona fasciculata morphology	CYP11B1 CYP11B2	7.95e-04	19	31	2	MP:0008294
MousePheno	abnormal renin activity	CYP11B1 CYP11B2	8.82e-04	20	31	2	MP:0005581
MousePheno	abnormal circulating corticosterone level	CYP11B1 CYP11B2 TLR2	9.54e-04	88	31	3	MP:0005345
MousePheno	abnormal circulating glucocorticoid level	CYP11B1 CYP11B2 TLR2	1.05e-03	91	31	3	MP:0003366
MousePheno	abnormal vascular development	DOCK4 PTK2B KDR PAX3 CUBN TLR2	1.06e-03	542	31	6	MP:0000259
MousePheno	abnormal corticosterone level	CYP11B1 CYP11B2 TLR2	1.15e-03	94	31	3	MP:0003963
MousePheno	increased circulating renin level	CYP11B1 CYP11B2	1.17e-03	23	31	2	MP:0003352
MousePheno	abnormal angiogenesis	DOCK4 PTK2B KDR PAX3 TLR2	1.25e-03	372	31	5	MP:0000260
MousePheno	oliguria	CYP11B1 CYP11B2	1.27e-03	24	31	2	MP:0003620
MousePheno	thin diaphragm muscle	PAX3 PAX7	1.61e-03	27	31	2	MP:0000761
MousePheno	premature death	PAX7 CUBN ECM1 LACTB2 NEUROD4 CFTR TLR2 CASK	1.65e-03	1051	31	8	MP:0002083
MousePheno	hypotension	CYP11B1 CYP11B2	1.74e-03	28	31	2	MP:0001596
MousePheno	abnormal respiration	SOX6 PLCB2 PAX3 LACTB2 CFTR TLR2	1.76e-03	598	31	6	MP:0001943
MousePheno	increased circulating pituitary hormone level	CYP11B1 CYP11B2 TLR2	1.82e-03	110	31	3	MP:0005117
MousePheno	abnormal circulating renin level	CYP11B1 CYP11B2	1.86e-03	29	31	2	MP:0003349
MousePheno	postnatal lethality	SOX6 PAX3 PAX7 NEUROD4 CYP11B1 CYP11B2 CFTR CASK	2.01e-03	1084	31	8	MP:0002082
MousePheno	abnormal corpus luteum morphology	CYP11B1 CYP11B2 CFTR	2.11e-03	116	31	3	MP:0002679
MousePheno	delayed neural tube closure	PAX3 SERPINH1	2.13e-03	31	31	2	MP:0002621
MousePheno	decreased urine output	CYP11B1 CYP11B2	2.41e-03	33	31	2	MP:0031358
MousePheno	lethality during fetal growth through weaning, incomplete penetrance	SOX6 CITED1 PAX3 PAX7 NEUROD4 CYP11B1 CYP11B2 CFTR	2.52e-03	1124	31	8	MP:0011112
MousePheno	abnormal neural crest cell migration	KDR PAX3	2.55e-03	34	31	2	MP:0002950
MousePheno	decreased circulating enzyme level	GZF1 CYP11B1 CYP11B2 TLR2	2.58e-03	263	31	4	MP:0014451
MousePheno	abnormal cell motility	ASPM PTK2B KDR PAX3 NUP210L CFTR TLR2	2.74e-03	885	31	7	MP:0020846
MousePheno	increased pituitary hormone level	CYP11B1 CYP11B2 TLR2	2.79e-03	128	31	3	MP:0003973
MousePheno	decreased thymus weight	CYP11B1 CYP11B2	2.86e-03	36	31	2	MP:0004956
MousePheno	abnormal ovary morphology	ASPM PTK2B CYP11B1 CYP11B2 CFTR	2.90e-03	451	31	5	MP:0001126
Domain	Pax7_C	PAX3 PAX7	4.03e-06	2	38	2	IPR022106
Domain	Pax7	PAX3 PAX7	4.03e-06	2	38	2	PF12360
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	4.03e-06	2	38	2	IPR002399
Domain	PAX	PAX3 PAX7	1.44e-04	9	38	2	SM00351
Domain	PAX	PAX3 PAX7	1.44e-04	9	38	2	PF00292
Domain	Paired_dom	PAX3 PAX7	1.44e-04	9	38	2	IPR001523
Domain	PAIRED_2	PAX3 PAX7	1.44e-04	9	38	2	PS51057
Domain	PAIRED_1	PAX3 PAX7	1.44e-04	9	38	2	PS00034
Domain	CUB	C1RL CUBN	4.46e-03	49	38	2	PF00431
Domain	CUB	C1RL CUBN	4.64e-03	50	38	2	SM00042
Domain	-	C1RL CUBN	5.01e-03	52	38	2	2.60.120.290
Domain	CUB	C1RL CUBN	5.20e-03	53	38	2	PS01180
Domain	Cyt_P450_CS	CYP11B1 CYP11B2	5.20e-03	53	38	2	IPR017972
Domain	CYTOCHROME_P450	CYP11B1 CYP11B2	6.00e-03	57	38	2	PS00086
Domain	CUB_dom	C1RL CUBN	6.00e-03	57	38	2	IPR000859
Domain	-	CYP11B1 CYP11B2	6.20e-03	58	38	2	1.10.630.10
Domain	p450	CYP11B1 CYP11B2	6.20e-03	58	38	2	PF00067
Domain	Cyt_P450	CYP11B1 CYP11B2	6.62e-03	60	38	2	IPR001128
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	3.26e-05	5	26	2	M47522
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.46e-04	10	26	2	M27076
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.78e-04	11	26	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.13e-04	12	26	2	MM14749
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.94e-04	14	26	2	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.94e-04	14	26	2	M46453
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2	3.86e-04	16	26	2	M39815
Pathway	REACTOME_SPECIFICATION_OF_THE_NEURAL_PLATE_BORDER	PAX3 PAX7	4.37e-04	17	26	2	M48248
Pathway	PID_S1P_S1P1_PATHWAY	KDR PLCB2	6.72e-04	21	26	2	M103
Pubmed	Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium.	KDR PAX3 PAX7	2.63e-07	12	38	3	31130354
Pubmed	Maternal corticosterone exposure in the mouse has sex-specific effects on placental growth and mRNA expression.	KDR CYP11B1 CYP11B2	2.63e-07	12	38	3	22919064
Pubmed	Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.	KDR PAX3 PAX7	6.67e-07	16	38	3	24927569
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	1.16e-06	2	38	2	23150505
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.16e-06	2	38	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	1.16e-06	2	38	2	21164264
Pubmed	Variation in the methylation profile and structure of Pax3 and Pax7 among different mouse strains and during expression.	PAX3 PAX7	1.16e-06	2	38	2	9016952
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	1.16e-06	2	38	2	8645611
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	1.16e-06	2	38	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	1.16e-06	2	38	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	1.16e-06	2	38	2	1303253
Pubmed	Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation.	PAX3 PAX7	1.16e-06	2	38	2	27346341
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	1.16e-06	2	38	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	1.16e-06	2	38	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	1.16e-06	2	38	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	1.16e-06	2	38	2	26324851
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	1.16e-06	2	38	2	7669222
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	1.16e-06	2	38	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.16e-06	2	38	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	1.16e-06	2	38	2	2256920
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	1.16e-06	2	38	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	1.16e-06	2	38	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	1.16e-06	2	38	2	16396990
Pubmed	Alternate PAX3 and PAX7 C-terminal isoforms in myogenic differentiation and sarcomagenesis.	PAX3 PAX7	1.16e-06	2	38	2	21421465
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	1.16e-06	2	38	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	1.16e-06	2	38	2	1518866
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	1.16e-06	2	38	2	23761669
Pubmed	An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.	PAX3 PAX7	1.16e-06	2	38	2	8943322
Pubmed	RNAi inhibition of Pax3/7 expression leads to markedly decreased expression of muscle determination genes.	PAX3 PAX7	1.16e-06	2	38	2	17396232
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	1.16e-06	2	38	2	2592361
Pubmed	Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells.	PAX3 PAX7	1.16e-06	2	38	2	16380438
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	1.16e-06	2	38	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	1.16e-06	2	38	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	1.16e-06	2	38	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	1.16e-06	2	38	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	1.16e-06	2	38	2	15731365
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	1.16e-06	2	38	2	17651452
Pubmed	Aberrant PAX3 and PAX7 expression. A link to the metastatic potential of embryonal rhabdomyosarcoma and cutaneous malignant melanoma?	PAX3 PAX7	1.16e-06	2	38	2	12647804
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	1.16e-06	2	38	2	34743356
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	1.16e-06	2	38	2	20339375
Pubmed	Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine.	CFTR TLR2	1.16e-06	2	38	2	34878935
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.16e-06	2	38	2	20808686
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	1.16e-06	2	38	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	1.16e-06	2	38	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	1.16e-06	2	38	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.16e-06	2	38	2	26066897
Pubmed	Comparison of the proximal promoter regions of the PAX3 and PAX7 genes.	PAX3 PAX7	1.16e-06	2	38	2	17954266
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	1.16e-06	2	38	2	18651133
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	1.16e-06	2	38	2	22083159
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	1.16e-06	2	38	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	1.16e-06	2	38	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	1.16e-06	2	38	2	38341019
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	1.16e-06	2	38	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	1.16e-06	2	38	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	1.16e-06	2	38	2	19820005
Pubmed	Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation.	PAX3 PAX7	1.16e-06	2	38	2	19221588
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	1.16e-06	2	38	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	1.16e-06	2	38	2	15062555
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	1.16e-06	2	38	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	1.16e-06	2	38	2	17075029
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	1.16e-06	2	38	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	1.16e-06	2	38	2	17296872
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	1.16e-06	2	38	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.16e-06	2	38	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	1.16e-06	2	38	2	15522937
Pubmed	Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration.	KDR PAX3 PAX7	2.10e-06	23	38	3	23946446
Pubmed	Pax3 functions in cell survival and in pax7 regulation.	PAX3 PAX7	3.48e-06	3	38	2	10079229
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	3.48e-06	3	38	2	2546938
Pubmed	PAX3/7-FOXO1 fusion status in older rhabdomyosarcoma patient population by fluorescent in situ hybridization.	PAX3 PAX7	3.48e-06	3	38	2	22089931
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	3.48e-06	3	38	2	16118390
Pubmed	Novel expression patterns of Pax3/Pax7 in early trunk neural crest and its melanocyte and non-melanocyte lineages in amniote embryos.	PAX3 PAX7	3.48e-06	3	38	2	16029418
Pubmed	Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice.	CFTR TLR2	3.48e-06	3	38	2	15731086
Pubmed	Detection of PAX3/PAX7-FKHR fusion transcripts in rhabdomyosarcoma and other small round cell tumors by 1-step reverse transcriptase polymerase chain reaction: a novel tool for diagnosis and differentiation.	PAX3 PAX7	3.48e-06	3	38	2	22197543
Pubmed	[Alveolar rhabdomyosarcoma: Two fusion-negative cases lacking PAX3-FOXO1 and PAX7-FOXO1].	PAX3 PAX7	3.48e-06	3	38	2	34980443
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	3.48e-06	3	38	2	17984374
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	3.48e-06	3	38	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	3.48e-06	3	38	2	33271253
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	3.48e-06	3	38	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	3.48e-06	3	38	2	11932209
Pubmed	[Expression of fusion gene PAX3/PAX7-FKHR and chromosomal aberration in rhabdomyosarcoma].	PAX3 PAX7	3.48e-06	3	38	2	17285543
Pubmed	PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.	PAX3 PAX7	3.48e-06	3	38	2	12039929
Pubmed	PAX3 Confers Functional Heterogeneity in Skeletal Muscle Stem Cell Responses to Environmental Stress.	PAX3 PAX7	3.48e-06	3	38	2	31006622
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	3.48e-06	3	38	2	21467193
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	3.48e-06	3	38	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	3.48e-06	3	38	2	26471128
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	3.48e-06	3	38	2	28355486
Pubmed	Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.	PAX3 PAX7	3.48e-06	3	38	2	10871843
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	3.48e-06	3	38	2	36861295
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	3.48e-06	3	38	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	3.48e-06	3	38	2	8111631
Pubmed	Conservation of the paired domain in metazoans and its structure in three isolated human genes.	PAX3 PAX7	3.48e-06	3	38	2	2501086
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	3.48e-06	3	38	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	3.48e-06	3	38	2	18974272
Pubmed	Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma.	PAX3 PAX7	3.48e-06	3	38	2	20351326
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	3.48e-06	3	38	2	1686470
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	3.48e-06	3	38	2	35830806
Pubmed	Pax3-fkhr and pax7-fkhr fusion genes impact outcome of alveolar rhabdomyosarcoma in children.	PAX3 PAX7	3.48e-06	3	38	2	17613043
Pubmed	Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs.	PAX3 PAX7	3.48e-06	3	38	2	35604932
Pubmed	Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function.	PAX3 PAX7	3.48e-06	3	38	2	31699935
Pubmed	Reporter-Based Isolation of Developmental Myogenic Progenitors.	PAX3 PAX7	3.48e-06	3	38	2	29674978
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	5.06e-06	3	24	2	1007
GeneFamily	Paired boxes	PAX3 PAX7	6.05e-05	9	24	2	675
GeneFamily	PRD class homeoboxes and pseudogenes	PAX3 PAX7	6.57e-03	92	24	2	521
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	GZF1 ZBTB11	1.35e-02	134	24	2	861
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 PTK2B PLCB2 TLR2 TBC1D2	6.83e-07	197	38	5	1eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCell	TCGA-Uvea\|World / Sample_Type by Project: Shred V9	SOX6 C16orf96 CITED1 PAX3	6.28e-06	141	38	4	015451a83087f2705d3315ebc8f23797c6f10ed6
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefm_(MGE-derived_cortical_interneurons--basket_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C16orf96 PAX7 CYP11B1	1.49e-05	56	38	3	ac776a6e8d0b5596dc492a05235e518cbfc7b5ed
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefm_(MGE-derived_cortical_interneurons--basket_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C16orf96 PAX7 CYP11B1	1.49e-05	56	38	3	0417516b9241a756fb2bcd611691c675ca98030d
ToppCell	LPS-antiTNF-Myeloid-Neutrophils-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 PTK2B DENND5A TLR2	1.57e-05	178	38	4	afcc92e8fe313c85eaf617cf4dbc3058da6c99d6
ToppCell	LPS-antiTNF-Myeloid-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 PTK2B DENND5A TLR2	1.57e-05	178	38	4	bd689205bc92cda5f71df64c2332ff76adcd84b4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 CITED1 ECM1	1.72e-05	182	38	4	f00eec1f434d92d44787d3d3343476c98c3de5b4
ToppCell	CF-Myeloid-Neutrophil\|CF / Disease state, Lineage and Cell class	DOCK4 DENND5A TLR2 TBC1D2	1.75e-05	183	38	4	da43827952e6fdee2ce94648c316182f272b321c
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	KDR CUBN KLK13 CFTR	1.91e-05	187	38	4	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	KDR KLK13 CFTR TLR2	1.91e-05	187	38	4	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	RA-08._Macrophage\|World / Chamber and Cluster_Paper	DOCK4 PTK2B TLR2 TBC1D2	2.16e-05	193	38	4	5fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	DOCK4 PTK2B TLR2 TBC1D2	2.21e-05	194	38	4	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	PTK2B CPT2 SOWAHC CFTR	2.48e-05	200	38	4	6b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	PTK2B CPT2 SOWAHC CFTR	2.48e-05	200	38	4	be83f442179ba4217d12f0458059586ff3130991
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-D\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CYP11B2 GPN2 TMEM89	7.52e-05	96	38	3	b671ae6a00b2f4ddf18d7a0b0cb15c34d9fb2a69
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-intermediate_monocyte\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DOCK4 CITED1 TLR2	2.39e-04	142	38	3	9b39c778cfaf457303010f1b1cae8c0cd8fe5d1d
ToppCell	TCGA-Adrenal\|World / Sample_Type by Project: Shred V9	NEUROD4 CYP11B1 CYP11B2	2.55e-04	145	38	3	522ad2bc90b8ec326fcbc7b2250b09566efeeca2
ToppCell	(07)_Ionocytes-(1)_GFP\|(07)_Ionocytes / shred by cell type by condition	DENND5A ECM1 NUP210L	2.65e-04	147	38	3	d398f49553ece2786c51e16e4bee028fb3833149
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTK2B PLCB2 TLR2	2.92e-04	152	38	3	bfc7ef4ee26165d18ac4f475a9519e8d52453ba2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM CUBN LACTB2	3.46e-04	161	38	3	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	E18.5-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PTK2B PLCB2 TLR2	3.52e-04	162	38	3	60d3fe1f5cec4285b8774ff078ebcc6bfaec26ed
ToppCell	E18.5-samps-Myeloid\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PTK2B PLCB2 TLR2	3.52e-04	162	38	3	18e4a807e25f754a69e9eaaddfde40f8de9b8512
ToppCell	E18.5-samps-Myeloid-Macrophage\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PTK2B PLCB2 TLR2	3.52e-04	162	38	3	0970e4eda60e3f015335e2726e6d565fb2f43372
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOWAHC TLR2 TBC1D2	3.65e-04	164	38	3	54f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCell	PND01-03-samps-Myeloid\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	PTK2B PLCB2 TLR2	3.78e-04	166	38	3	99dc8a186ec12d3563e81fa4618a814740332c73
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLK13 SERPINH1 TMEM89	3.78e-04	166	38	3	7495961adcefe5c1fb288913b1a5236328a04703
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	C16orf96 KDR DENND5A	4.06e-04	170	38	3	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR KLK13 CFTR	4.13e-04	171	38	3	d5960b40ad5b87aaa00c93a6b31cdf41cc4f1375
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR KLK13 CFTR	4.13e-04	171	38	3	fd59ac4a39748840b2ee1c930ea475433ff61485
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR KLK13 CFTR	4.13e-04	171	38	3	d382430e5cdd0f2aac4fc093d8fe8d66efb4629b
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR KLK13 CFTR	4.13e-04	171	38	3	4347e6f62c04ea43299893ad4b79719049009a56
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PAX3 PAX7 NUP210L	4.13e-04	171	38	3	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1RL SOWAHC TLR2	4.20e-04	172	38	3	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CITED1 ZNF142 COG7	4.20e-04	172	38	3	1bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 KDR PAX7	4.27e-04	173	38	3	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KDR NUP210L TBC1D2	4.27e-04	173	38	3	66488d01e03264fb193285470901c9c4182fbae8
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SOX6 PAX3 ZNF142	4.41e-04	175	38	3	085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCell	facs-BAT-Fat-3m-Epithelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CITED1 GPN2 NMNAT3	4.56e-04	177	38	3	3e42f6236962dd9bb23dc0d09b460ec8347d1056
ToppCell	facs-BAT-Fat-3m-Epithelial-epithelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CITED1 GPN2 NMNAT3	4.56e-04	177	38	3	128186bc996784e670194c07c5352e69af5f6d68
ToppCell	facs-BAT-Fat-3m-Epithelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CITED1 GPN2 NMNAT3	4.56e-04	177	38	3	7480e522cfae3f5c6c62720083750f8273725ab5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK4 DENND5A TLR2	4.64e-04	178	38	3	fbf49766e1504df554856b84c0576c06f3167329
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK4 SERPINH1 TLR2	4.72e-04	179	38	3	2fca4117c58824562ec80c7713fe15689a28efb3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK4 SERPINH1 TLR2	4.72e-04	179	38	3	898425fa81526a2e00fca7a25085229ff1f31069
ToppCell	LPS_only-Myeloid-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.72e-04	179	38	3	d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KLK13 CFTR TLR2	4.72e-04	179	38	3	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	LPS_only-Myeloid-Neutrophils-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.72e-04	179	38	3	d034651a5a355a58f5e15db627869f4feebdfe35
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	4.72e-04	179	38	3	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	NS\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PAX3 PAX7 ECM1	4.79e-04	180	38	3	8472dcce7bc0b7ce428ec17ddf0018f3258f78d2
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DOCK4 SERPINH1 TLR2	4.79e-04	180	38	3	dcec59d66995f701d816eaeea3ed1439a2f71b73
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	DOCK4 SERPINH1 TLR2	4.79e-04	180	38	3	f3d8329b7e754c1ed89b0f39b8cd9e2ae22f6725
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 PAX3 KLK13	4.79e-04	180	38	3	dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCell	Control-Myeloid-MoAM2\|Control / Disease group,lineage and cell class （2021.01.30）	DOCK4 SERPINH1 TLR2	4.79e-04	180	38	3	38892483a6a5388765aec87f0119c0b9bb5c7cbd
ToppCell	LPS-IL1RA-Myeloid-Neutrophils-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.79e-04	180	38	3	c0c07937839652e01df10cc1e70aa005800ea6f6
ToppCell	LPS-IL1RA-Myeloid-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.79e-04	180	38	3	079c199425dd3c220f03c6dca1823946f07580a1
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ASPM DOCK4 TLR2	4.79e-04	180	38	3	cf7d8bf9eee2dfab2c8a6780e296b05ad42041bf
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 PAX3 KLK13	4.79e-04	180	38	3	d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCell	NS-critical-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KDR CITED1 PAX3	4.95e-04	182	38	3	dd1c59babf7211362452e3e264009d70004d99f6
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.95e-04	182	38	3	243c783675df495ea4112dbf710712c44ea6b4f1
ToppCell	LPS_only-Myeloid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.95e-04	182	38	3	666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	4.95e-04	182	38	3	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 PAX3 KLK13	4.95e-04	182	38	3	812ff2a50a510b18d865e89465dba1754a08ef61
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	4.95e-04	182	38	3	18790a394dc32b3cef99cdbf826392c520e38b4a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	4.95e-04	182	38	3	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CITED1 KLK13 CFTR	5.03e-04	183	38	3	263937906ddabc798bbe60f0da28ba859a5c72e2
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_progenitors\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KDR KLK13 CFTR	5.11e-04	184	38	3	fcb5dd4fb3fa79f3b6029fad32a474cacde35a3b
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	DOCK4 PTK2B TLR2	5.11e-04	184	38	3	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	moderate-Lymphoid-NK\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KDR CITED1 SERPINH1	5.19e-04	185	38	3	4979a787acbc9b4ca8defe91cc79b674e51af1bf
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CITED1 KLK13 CFTR	5.19e-04	185	38	3	01d0e848d8ede2745cfb10b070e2d9674ef4d477
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK4 DENND5A TLR2	5.19e-04	185	38	3	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	LPS-IL1RA-Myeloid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	5.19e-04	185	38	3	9b5fd87ea9d05e051ff1251578ecfbe5e8652853
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR KLK13 CFTR	5.27e-04	186	38	3	55fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCell	LPS-antiTNF-Myeloid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	5.27e-04	186	38	3	839c6da5244f469461b2e5563e36162b2911cd01
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	5.27e-04	186	38	3	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	LPS-IL1RA+antiTNF-Myeloid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTK2B DENND5A TLR2	5.36e-04	187	38	3	4e0bbef6ba0d1b3e1f8d900d4a9dbd41f09a7bc5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 KDR	5.44e-04	188	38	3	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	DOCK4 PTK2B TLR2	5.52e-04	189	38	3	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	5.52e-04	189	38	3	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	moderate-Lymphoid-NK\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KDR CITED1 ECM1	5.52e-04	189	38	3	22a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCell	droplet-Lung-nan-18m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf96 KLK13 CFTR	5.61e-04	190	38	3	b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	5.61e-04	190	38	3	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	Control-Myeloid-Transitioning_MDM\|Control / group, cell type (main and fine annotations)	DOCK4 PTK2B TLR2	5.61e-04	190	38	3	d6fd8c23cde4a10cc1517b6899a5a855fdfff2e2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	5.61e-04	190	38	3	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-RGCs_early_2\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	PAX3 PAX7 SERPINH1	5.69e-04	191	38	3	06107849463a1ccb78a5ccd3ae31619ef6bedda3
ToppCell	COVID-19-kidney-Stressed_EC\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK4 KDR SERPINH1	5.69e-04	191	38	3	d35aa842b813ea0eff7362abc894cca4e86b2fb2
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SOX6 CFTR TLR2	5.69e-04	191	38	3	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	(1)_Control_(PBS)\|World / Stress and Cell class	KDR ECM1 SERPINH1	5.69e-04	191	38	3	b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Club\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KDR KLK13 CFTR	5.78e-04	192	38	3	044c7ae56da17cacf2705efa8ac2c8aeba6cfeee
ToppCell	Control-Myeloid-cMonocyte\|Control / Disease state, Lineage and Cell class	DOCK4 PTK2B TLR2	5.78e-04	192	38	3	ad04c9c4bdebf94615cee1904ca48197e62c923b
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CITED1 KLK13 CFTR	5.78e-04	192	38	3	d6ea34391c3f730684b82e912d9cf55e928b3311
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DENND5A ZBTB11 SERPINH1	5.78e-04	192	38	3	3f925a80b5e2b0577d573e88598a2984a5f6a789
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 CUBN EXOC4	5.78e-04	192	38	3	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR ECM1 SERPINH1	5.87e-04	193	38	3	5d42979d811ee13a07dee08a3743a90776017cb4
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR ECM1 SERPINH1	5.87e-04	193	38	3	95e64b9580d30c28702639a043a8b72ce1cadeb6
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR ECM1 SERPINH1	5.87e-04	193	38	3	97c0730aad9135ac681250b3871cc094a28f80a7
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK4 DENND5A EXOC4	5.87e-04	193	38	3	779276e775cb2492e8dd36436295a536084a6415
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	ASPM PTK2B TLR2	5.87e-04	193	38	3	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASPM SOX6 ECM1	5.87e-04	193	38	3	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DENND5A ZBTB11 SERPINH1	5.87e-04	193	38	3	dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASPM KDR CYP11B1	5.87e-04	193	38	3	1b69f92c6a7a2516e393d3f3c371407ec791343d
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 KDR CASK	5.87e-04	193	38	3	e1d546165dcc2392f540162206852c4717d7306f
Drug	3,4,5,3',4',5'-hexachlorobiphenyl	KDR CYP11B1 CYP11B2	1.21e-06	13	38	3	ctd:C027309
Drug	cyadox	CYP11B1 CYP11B2	2.71e-06	2	38	2	ctd:C020728
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	2.71e-06	2	38	2	ctd:C042509
Drug	18-hydroxycortisol	CYP11B1 CYP11B2	8.13e-06	3	38	2	ctd:C033689
Drug	C05489	CYP11B1 CYP11B2	1.62e-05	4	38	2	CID000440708
Drug	17alpha, 21-dihydroxypregnenolone	CYP11B1 CYP11B2	2.70e-05	5	38	2	CID000192735
Drug	Tetrahydronaphthalenes	CYP11B1 CYP11B2	4.05e-05	6	38	2	ctd:D013764
Drug	Methandrostenolone	CYP11B1 CYP11B2	4.05e-05	6	38	2	ctd:D008696
Drug	AC1Q6X9N	CUBN CYP11B2 CFTR	4.71e-05	42	38	3	CID000072205
Drug	Cortodoxone	CYP11B1 CYP11B2	5.67e-05	7	38	2	ctd:D003350
Drug	2,2',3,3',4,6'-hexachlorobiphenyl	CYP11B1 CYP11B2	7.55e-05	8	38	2	ctd:C094859
Drug	Ag43	PTK2B CFTR	7.55e-05	8	38	2	CID000005613
Drug	GKT137831	CYP11B1 CYP11B2	9.69e-05	9	38	2	ctd:C576694
Drug	2,2',3,4',5',6-hexachlorobiphenyl	CYP11B1 CYP11B2	9.69e-05	9	38	2	ctd:C120129
Drug	angiotensin	PTK2B PLCB2 KLK13 CYP11B1 CYP11B2	1.01e-04	282	38	5	CID003083715
Drug	Indans	CYP11B1 CYP11B2	1.21e-04	10	38	2	ctd:D007189
Drug	perflubron	CYP11B1 CYP11B2	1.21e-04	10	38	2	ctd:C003072
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	1.61e-06	2	38	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	1.61e-06	2	38	2	C1260386
Disease	Alveolar rhabdomyosarcoma	PAX3 PAX7	4.84e-06	3	38	2	cv:C0206655
Disease	RHABDOMYOSARCOMA 2	PAX3 PAX7	4.84e-06	3	38	2	268220
Disease	alveolar rhabdomyosarcoma (is_implicated_in)	PAX3 PAX7	4.84e-06	3	38	2	DOID:4051 (is_implicated_in)
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	4.84e-06	3	38	2	DOID:0050811 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	1.61e-05	5	38	2	DOID:446 (is_implicated_in)
Disease	Alveolar rhabdomyosarcoma	PAX3 PAX7	1.61e-05	5	38	2	C0206655
Disease	Conn Syndrome	CYP11B1 CYP11B2	2.41e-05	6	38	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	2.41e-05	6	38	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	3.38e-05	7	38	2	EFO_0801973
Disease	complement factor H-related protein 1 measurement	ASPM CYP11B1 CYP11B2	5.21e-05	56	38	3	EFO_0600054
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	5.78e-05	9	38	2	EFO_0802936
Disease	adseverin measurement	C1RL CYP11B1	7.22e-05	10	38	2	EFO_0801358
Disease	androstenedione measurement	CYP11B1 CYP11B2	7.22e-05	10	38	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	8.82e-05	11	38	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	8.82e-05	11	38	2	EFO_0801461
Disease	beverage consumption measurement	DOCK4 INTS7 EXOC4	1.69e-04	83	38	3	EFO_0010088
Disease	hypertension (biomarker_via_orthology)	PTK2B KDR CYP11B1 CYP11B2	2.05e-04	227	38	4	DOID:10763 (biomarker_via_orthology)
Disease	lung disease (is_implicated_in)	CFTR TLR2	3.67e-04	22	38	2	DOID:850 (is_implicated_in)
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	4.75e-04	25	38	2	EFO_0021854
Disease	hypertension (is_implicated_in)	PTK2B KDR CYP11B2	5.11e-04	121	38	3	DOID:10763 (is_implicated_in)
Disease	prostate cancer (implicated_via_orthology)	PAX3 PAX7	8.31e-04	33	38	2	DOID:10283 (implicated_via_orthology)
Disease	brain infarction (biomarker_via_orthology)	CYP11B1 CYP11B2	8.31e-04	33	38	2	DOID:3454 (biomarker_via_orthology)
Disease	vitamin D measurement	SOX6 C16orf96 PAX3 EXOC4	8.98e-04	336	38	4	EFO_0004631
Disease	brain ischemia (implicated_via_orthology)	PTK2B KDR	9.35e-04	35	38	2	DOID:2316 (implicated_via_orthology)
Disease	heart disease (implicated_via_orthology)	SOX6 CYP11B1	1.10e-03	38	38	2	DOID:114 (implicated_via_orthology)
Disease	Anorectal Malformations	SOX6 CASK	1.28e-03	41	38	2	C3495676

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGLEMALLPHLHEHN	COG7	326	P83436
KILHHKMLHSVLQAP	CFTR	946	P13569
NLLHEMHELRLLGHL	GZF1	16	Q9H116
PAKIAHEHFLMIKRH	ASPM	3016	Q8IZT6
PIKDLVHLSHNMLHG	CPT2	331	P23786
VDLKLKLIPILQHMH	INTS7	191	Q9NVH2
KLIPILQHMHHDAIL	INTS7	196	Q9NVH2
LPNHIRHKIVEMAHH	PAX7	51	P23759
PTHLNHDHDIMLLEL	KLK13	116	Q9UKR3
CHMLKHPHIVELLET	CASK	66	O14936
LPHINLLSKMDLIEH	GPN2	171	Q9H9Y4
ENLHEMAKHNLLLHL	LACTB2	251	Q53H82
LPNHIRHKIVEMAHH	PAX3	51	P23760
HILVQPNHLIHLMFE	CUBN	961	O60494
MNLHLVLIDELHRHL	EXOC4	186	Q96A65
HHLHIHLQEQKDLIM	DOCK4	836	Q8N1I0
LHLLLHGILEHIHMA	C16orf96	26	A6NNT2
MLKLGNHPVHRVVVH	C1RL	311	Q9NZP8
AEAEMLLLLHHVLKH	CYP11B1	456	P15538
IDHTAIHPHLLDMKI	DENND5A	646	Q6IQ26
AEAEMLLLLHHVLKH	CYP11B2	456	P19099
VLTKHKHIPGLIHNM	ECM1	431	Q16610
VIMKNLDHPHIVKLI	PTK2B	476	Q14289
IHVLKLNKMELLPFH	NUP210L	541	Q5VU65
ISIMLHELIKLLHHA	UPP2	121	O95045
AHKLSSLIILMPHHV	SERPINH1	261	P50454
HLAAMHGHVEVVKLL	SOWAHC	346	Q53LP3
HVASHLPLHPIMHNK	SOX6	36	P35712
HPAPHLLASMHLQKL	CITED1	86	Q99966
LRIHMLKHTGVKPHA	ZBTB11	666	O95625
DKLLLHHDMTQPLNH	PLCB2	306	Q00722
LHMLDALLVHIEGHL	TMEM89	126	A2RUT3
ALMSELKILIHIGHH	KDR	881	P35968
LIRHMLLHTGEKPHK	ZNF142	416	P52746
SHLILHMKQHILLLE	TLR2	201	O60603
SPHHMLHLQAAKLAL	VWA7	271	Q9Y334
LPRLMAHLGQHHVDL	TBC1D2	771	Q9BYX2
HMETHLLHLKPQVFK	NEUROD4	216	Q9HD90
ILRMHQHNIHLAKEP	NMNAT3	181	Q96T66