Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	EYA4 PTPN22 PTPRT PTPN3 DUSP16	1.26e-04	103	94	5	GO:0004725
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	EYA4 PTPN22 PTPRT PTPN3 DUSP16 TNS1	2.71e-04	189	94	6	GO:0004721
GeneOntologyBiologicalProcess	dense core granule docking	UNC13B UNC13A	2.01e-05	2	93	2	GO:0061790
GeneOntologyBiologicalProcess	regulation of membrane potential	AKAP6 UNC13B CACNA1D RELN FFAR3 GPR42 CRTC1 SHANK3 PTPN3 KCNG1 KDR	4.30e-05	559	93	11	GO:0042391
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	6.02e-05	3	93	2	GO:0002879
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.20e-04	4	93	2	GO:0002877
GeneOntologyBiologicalProcess	dense core granule priming	UNC13B UNC13A	1.20e-04	4	93	2	GO:0061789
GeneOntologyBiologicalProcess	positive regulation of nervous system process	UNC13B FFAR3 GPR42 TENM4	1.27e-04	57	93	4	GO:0031646
GeneOntologyBiologicalProcess	regulation of nervous system process	UNC13B RELN FFAR3 GPR42 SHANK3 TENM4	1.42e-04	175	93	6	GO:0031644
GeneOntologyBiologicalProcess	positive regulation of AMPA receptor activity	RELN SHANK3	1.99e-04	5	93	2	GO:2000969
GeneOntologyBiologicalProcess	positive regulation of glutamate receptor signaling pathway	SHANK3 UNC13A	1.99e-04	5	93	2	GO:1900451
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.99e-04	5	93	2	GO:0002525
GeneOntologyBiologicalProcess	neuron development	RELN GAK IRX5 FAT3 NR4A2 LMTK2 PCDHAC2 CRTC1 ITGA1 CSMD3 SHANK3 TENM4 KDR ALCAM CDH4 UNC13A ANKS1A	2.63e-04	1463	93	17	GO:0048666
GeneOntologyBiologicalProcess	cell morphogenesis	EPS8 RELN SHROOM3 FAT3 SPTA1 NR4A2 LMTK2 PCDHAC2 ITGA1 SHANK3 ST14 KDR ALCAM CDH4 UNC13A	2.78e-04	1194	93	15	GO:0000902
GeneOntologyBiologicalProcess	NMDA glutamate receptor clustering	RELN SHANK3	2.98e-04	6	93	2	GO:0097114
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	2.98e-04	6	93	2	GO:1904457
GeneOntologyBiologicalProcess	action potential	AKAP6 CACNA1D FFAR3 GPR42 PTPN3 KCNG1	3.00e-04	201	93	6	GO:0001508
Domain	-	GAK PTPN22 PTPRT PTPN3 DUSP16 TNS1	6.54e-06	92	93	6	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	GAK PTPN22 PTPRT PTPN3 DUSP16 TNS1	1.00e-05	99	93	6	IPR029021
Domain	NBPF_dom	NBPF11 NBPF9 NBPF14	1.92e-05	11	93	3	IPR010630
Domain	NBPF	NBPF11 NBPF9 NBPF14	1.92e-05	11	93	3	PS51316
Domain	DUF1220	NBPF11 NBPF9 NBPF14	1.92e-05	11	93	3	PF06758
Domain	Unc-13	UNC13B UNC13A	7.33e-05	3	93	2	IPR027080
Domain	ConA-like_dom	FAT3 TRIM21 ADGRG4 PTPRT SVEP1 BTNL3 TRIM17	1.12e-04	219	93	7	IPR013320
Domain	GPR40-rel_orph	FFAR3 GPR42	1.46e-04	4	93	2	IPR013312
Domain	PTPc_motif	PTPN22 PTPRT PTPN3 TNS1	2.13e-04	59	93	4	SM00404
Domain	Tyr_Pase_cat	PTPN22 PTPRT PTPN3 TNS1	2.13e-04	59	93	4	IPR003595
Domain	Munc13_dom-2	UNC13B UNC13A	2.43e-04	5	93	2	IPR014772
Domain	Membr_traf_MHD	UNC13B UNC13A	2.43e-04	5	93	2	PF10540
Domain	MHD2	UNC13B UNC13A	2.43e-04	5	93	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13A	2.43e-04	5	93	2	IPR019558
Domain	DUF1041	UNC13B UNC13A	2.43e-04	5	93	2	SM01145
Domain	Tyr_Pase_AS	PTPN22 PTPRT PTPN3 DUSP16	4.82e-04	73	93	4	IPR016130
Domain	DUF1041	UNC13B UNC13A	5.07e-04	7	93	2	PF06292
Domain	Munc13_1	UNC13B UNC13A	5.07e-04	7	93	2	IPR014770
Domain	CAPS_dom	UNC13B UNC13A	5.07e-04	7	93	2	IPR010439
Domain	MHD1	UNC13B UNC13A	5.07e-04	7	93	2	PS51258
Domain	-	CPA5 CPA1	6.74e-04	8	93	2	3.30.70.340
Domain	PTEN_C2	GAK TNS1	6.74e-04	8	93	2	SM01326
Domain	PTEN_C2	GAK TNS1	6.74e-04	8	93	2	PF10409
Domain	PTB	EPS8 TNS1	6.74e-04	8	93	2	PF08416
Domain	PTB	EPS8 TNS1	6.74e-04	8	93	2	IPR013625
Domain	Ubox	TRIM21 PRPF19	6.74e-04	8	93	2	SM00504
Domain	C2_TENSIN	GAK TNS1	6.74e-04	8	93	2	PS51182
Domain	Tensin_lipid_phosphatase_dom	GAK TNS1	6.74e-04	8	93	2	IPR029023
Domain	Propep_M14	CPA5 CPA1	6.74e-04	8	93	2	PF02244
Domain	Tensin_C2-dom	GAK TNS1	6.74e-04	8	93	2	IPR014020
Domain	M14A_act_pep	CPA5 CPA1	6.74e-04	8	93	2	IPR003146
Domain	PDZ	SHROOM3 PARD3B SHANK3 PTPN3 PATJ	6.97e-04	141	93	5	PF00595
Domain	PTPc	PTPN22 PTPRT PTPN3	7.58e-04	36	93	3	SM00194
Domain	PPASE_TENSIN	GAK TNS1	8.63e-04	9	93	2	PS51181
Domain	DUF1220	NBPF11 NBPF9	8.63e-04	9	93	2	SM01148
Domain	PDZ	SHROOM3 PARD3B SHANK3 PTPN3 PATJ	8.67e-04	148	93	5	SM00228
Domain	TYR_PHOSPHATASE_1	PTPN22 PTPRT PTPN3 DUSP16	8.96e-04	86	93	4	PS00383
Domain	-	SHROOM3 PARD3B SHANK3 PTPN3 PATJ	9.21e-04	150	93	5	2.30.42.10
Domain	TYR_PHOSPHATASE_2	PTPN22 PTPRT PTPN3 DUSP16	9.35e-04	87	93	4	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPN22 PTPRT PTPN3 DUSP16	9.35e-04	87	93	4	IPR000387
Domain	PDZ	SHROOM3 PARD3B SHANK3 PTPN3 PATJ	9.49e-04	151	93	5	PS50106
Domain	TYR_PHOSPHATASE_PTP	PTPN22 PTPRT PTPN3	9.59e-04	39	93	3	PS50055
Domain	PDZ	SHROOM3 PARD3B SHANK3 PTPN3 PATJ	9.77e-04	152	93	5	IPR001478
Domain	PTB	EPS8 TNS1 ANKS1A	1.03e-03	40	93	3	SM00462
Domain	Ubox_domain	TRIM21 PRPF19	1.08e-03	10	93	2	IPR003613
Domain	PTX	ADGRG4 SVEP1	1.08e-03	10	93	2	SM00159
Domain	PTPase_domain	PTPN22 PTPRT PTPN3	1.11e-03	41	93	3	IPR000242
Domain	Y_phosphatase	PTPN22 PTPRT PTPN3	1.11e-03	41	93	3	PF00102
Domain	PTB/PI_dom	EPS8 TNS1 ANKS1A	1.11e-03	41	93	3	IPR006020
Domain	Pentaxin-related	ADGRG4 SVEP1	1.31e-03	11	93	2	IPR001759
Domain	Pentaxin	ADGRG4 SVEP1	1.31e-03	11	93	2	PF00354
Domain	C2_dom	UNC13B GAK PIK3C2B TNS1 UNC13A	1.37e-03	164	93	5	IPR000008
Domain	PRY	TRIM21 BTNL3 TRIM17	1.76e-03	48	93	3	SM00589
Domain	PRY	TRIM21 BTNL3 TRIM17	1.76e-03	48	93	3	IPR006574
Domain	Cadherin_CS	PCDHGA6 FAT3 PCDHAC2 CDH4	2.15e-03	109	93	4	IPR020894
Domain	CADHERIN_1	PCDHGA6 FAT3 PCDHAC2 CDH4	2.45e-03	113	93	4	PS00232
Domain	Cadherin	PCDHGA6 FAT3 PCDHAC2 CDH4	2.45e-03	113	93	4	PF00028
Domain	CADHERIN_2	PCDHGA6 FAT3 PCDHAC2 CDH4	2.53e-03	114	93	4	PS50268
Domain	-	PCDHGA6 FAT3 PCDHAC2 CDH4	2.53e-03	114	93	4	2.60.40.60
Domain	CA	PCDHGA6 FAT3 PCDHAC2 CDH4	2.61e-03	115	93	4	SM00112
Domain	Cadherin-like	PCDHGA6 FAT3 PCDHAC2 CDH4	2.70e-03	116	93	4	IPR015919
Domain	VWA	COL6A3 ITGA1 SVEP1	2.74e-03	56	93	3	PF00092
Domain	Cadherin	PCDHGA6 FAT3 PCDHAC2 CDH4	2.87e-03	118	93	4	IPR002126
Domain	Propept_inh	CPA5 CPA1	3.18e-03	17	93	2	IPR009020
Domain	EGF_extracell	RELN SVEP1 TENM4	3.33e-03	60	93	3	IPR013111
Domain	EGF_2	RELN SVEP1 TENM4	3.33e-03	60	93	3	PF07974
Domain	Zn_pept	CPA5 CPA1	3.56e-03	18	93	2	SM00631
Domain	CARBOXYPEPT_ZN_2	CPA5 CPA1	3.97e-03	19	93	2	PS00133
Domain	CARBOXYPEPT_ZN_1	CPA5 CPA1	4.40e-03	20	93	2	PS00132
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL6A3 COL8A2 COL10A1 ITGA1 KDR	5.47e-05	85	68	5	M16441
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF8 NBPF12 NBPF11 NBPF9 NBPF10 NBPF14	2.87e-11	21	102	6	16079250
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF12 NBPF9 NBPF14	1.44e-08	10	102	4	22973535
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 COL6A3 NBPF12 CPA5 APOB NBPF11 CSMD3 NBPF9 NBPF10 PRPF19 IGSF1 NBPF14	3.79e-08	513	102	12	25798074
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 SHROOM3 LMTK2 SIK1 CRTC1 PARD3B SORBS1 TAB3 ARFGEF3 PTPN3 PIK3C2B NHS PATJ ANKS1A	2.32e-07	861	102	14	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 RALGAPA1 SHROOM3 LMTK2 CRTC1 USP38 DDHD1 HPS4 SCAF11 IGSF1 ANKS1A	4.66e-07	529	102	11	14621295
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	8.52e-06	2	102	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	8.52e-06	2	102	2	30478340
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	8.52e-06	2	102	2	35858247
Pubmed	Regulation of insulin exocytosis by Munc13-1.	UNC13B UNC13A	8.52e-06	2	102	2	12871971
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	8.52e-06	2	102	2	22506074
Pubmed	Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.	UNC13B UNC13A	8.52e-06	2	102	2	17561838
Pubmed	Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.	UNC13B UNC13A	8.52e-06	2	102	2	28489077
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	8.52e-06	2	102	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	8.52e-06	2	102	2	36362376
Pubmed	Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.	UNC13B UNC13A	8.52e-06	2	102	2	10440375
Pubmed	Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.	UNC13B UNC13A	8.52e-06	2	102	2	22066784
Pubmed	Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.	UNC13B UNC13A	8.52e-06	2	102	2	32187536
Pubmed	Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.	UNC13B UNC13A	8.52e-06	2	102	2	22814762
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	8.52e-06	2	102	2	20399779
Pubmed	Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.	UNC13B UNC13A	8.52e-06	2	102	2	28426965
Pubmed	Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.	UNC13B UNC13A	8.52e-06	2	102	2	23770256
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	8.52e-06	2	102	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	8.52e-06	2	102	2	26522986
Pubmed	Phospholipase D and mTORC1: nutrients are what bring them together.	CRTC1 PLD1	8.52e-06	2	102	2	22457329
Pubmed	[Association of polymorphic markers rs7947461 of the TRIM21 gene and rs33996649 of the PTPN22 gene with the risk of developing exogenous dry eye syndrome].	PTPN22 TRIM21	8.52e-06	2	102	2	34669330
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	8.52e-06	2	102	2	27664183
Pubmed	Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.	UNC13B UNC13A	8.52e-06	2	102	2	31851910
Pubmed	Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.	UNC13B UNC13A	8.52e-06	2	102	2	11832228
Pubmed	Munc13 controls the location and efficiency of dense-core vesicle release in neurons.	UNC13B UNC13A	8.52e-06	2	102	2	23229896
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	8.52e-06	2	102	2	37019194
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	8.52e-06	2	102	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	8.52e-06	2	102	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	8.52e-06	2	102	2	26091414
Pubmed	Integrin alpha1 localization in murine central and peripheral nervous system.	RELN ITGA1	8.52e-06	2	102	2	9603370
Pubmed	Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.	UNC13B UNC13A	8.52e-06	2	102	2	12070347
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	8.52e-06	2	102	2	27550964
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	8.52e-06	2	102	2	32073900
Pubmed	Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.	UNC13B UNC13A	8.52e-06	2	102	2	23070049
Pubmed	Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	UNC13B UNC13A	8.52e-06	2	102	2	28772123
Pubmed	Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.	UNC13B UNC13A	8.52e-06	2	102	2	17267576
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	8.52e-06	2	102	2	19630535
Pubmed	A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.	UNC13B UNC13A	8.52e-06	2	102	2	35613050
Pubmed	Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1.	SIK1 CRTC1	8.52e-06	2	102	2	29408765
Pubmed	Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.	SIK1 CRTC1	8.52e-06	2	102	2	36434056
Pubmed	Membrane bridging by Munc13-1 is crucial for neurotransmitter release.	UNC13B UNC13A	8.52e-06	2	102	2	30816091
Pubmed	Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels.	CACNA1D SHANK3	8.52e-06	2	102	2	30058071
Pubmed	A common molecular basis for membrane docking and functional priming of synaptic vesicles.	UNC13B UNC13A	8.52e-06	2	102	2	19558619
Pubmed	Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.	UNC13B UNC13A	8.52e-06	2	102	2	18701688
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	8.52e-06	2	102	2	14722361
Pubmed	Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.	UNC13B UNC13A	8.52e-06	2	102	2	11792326
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	8.52e-06	2	102	2	26260360
Pubmed	Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.	ITGA1 TENM4 ALCAM CDH4	1.13e-05	47	102	4	15172686
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 NBPF12 NBPF11 NBPF9 NBPF10 NBPF14	1.14e-05	170	102	6	23314748
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RALGAPA1 ELOA EYA4 LMTK2 PTPN22 PTPRT TAB3 PTPN3 SUN2 DUSP16 NHS PRPF19 TNS1	1.24e-05	1049	102	13	27880917
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	SHROOM3 PARD3B PTPN3 PIK3C2B ANKS1A	1.31e-05	102	102	5	15778465
Pubmed	Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.	RELN SP8 PROKR2	2.29e-05	19	102	3	28981617
Pubmed	Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis.	SIK1 CRTC1	2.55e-05	3	102	2	31672960
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	2.55e-05	3	102	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	2.55e-05	3	102	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	2.55e-05	3	102	2	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	2.55e-05	3	102	2	31719611
Pubmed	IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells.	ITGA1 CXCR6	2.55e-05	3	102	2	28952190
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	2.55e-05	3	102	2	25581519
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13A	2.55e-05	3	102	2	33105896
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	2.55e-05	3	102	2	31272808
Pubmed	TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.	SIK1 CRTC1	2.55e-05	3	102	2	17565599
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	2.55e-05	3	102	2	38524121
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	2.55e-05	3	102	2	22673524
Pubmed	Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.	UNC13B UNC13A	2.55e-05	3	102	2	37343100
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13A	2.55e-05	3	102	2	23658173
Pubmed	Serum Glycoprotein Biomarker Discovery and Qualification Pipeline Reveals Novel Diagnostic Biomarker Candidates for Esophageal Adenocarcinoma.	APOB C9	2.55e-05	3	102	2	26404905
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	2.55e-05	3	102	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	2.55e-05	3	102	2	22493486
Pubmed	The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.	SIK1 CRTC1	2.55e-05	3	102	2	23993098
Pubmed	Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.	UNC13B UNC13A	2.55e-05	3	102	2	17639022
Pubmed	Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.	CACNA1D ALCAM	2.55e-05	3	102	2	23753573
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	2.55e-05	3	102	2	23066016
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	2.55e-05	3	102	2	22190648
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	2.55e-05	3	102	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	2.55e-05	3	102	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	2.55e-05	3	102	2	18931303
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13A	2.55e-05	3	102	2	22966208
Pubmed	Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development.	RELN KDR	2.55e-05	3	102	2	7734734
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	2.55e-05	3	102	2	38329121
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13A	2.55e-05	3	102	2	15988013
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	RELN PCDHGA6 PCDHAC2 SP8	2.62e-05	58	102	4	30377227
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	NR4A2 ITGA1 CSMD3	3.62e-05	22	102	3	35245678
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	RALGAPA1 EPS8 SLCO4A1 APOB ST14 PTPN3 ALCAM PATJ KDF1	4.69e-05	569	102	9	30639242
Pubmed	Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.	UNC13B UNC13A	5.09e-05	4	102	2	10488064
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	5.09e-05	4	102	2	23401498
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	5.09e-05	4	102	2	9344866
Pubmed	VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins.	ITGA1 KDR	5.09e-05	4	102	2	15132990
Pubmed	Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.	SIK1 CRTC1	5.09e-05	4	102	2	16817901
Pubmed	Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.	CPA5 CPA1	5.09e-05	4	102	2	11920156
Pubmed	Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.	UNC13B UNC13A	5.09e-05	4	102	2	19996097
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	5.09e-05	4	102	2	21518883
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	5.09e-05	4	102	2	15684720
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	5.09e-05	4	102	2	29644622
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	UNC13B UNC13A	5.09e-05	4	102	2	15123597
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B UNC13A	5.09e-05	4	102	2	28264913
Interaction	YWHAG interactions	RALGAPA1 SHROOM3 ZBTB33 LMTK2 SIK1 CRTC1 PARD3B TRIM21 SORBS1 SHANK3 TAB3 PTPN3 PIK3C2B DUSP16 NHS PRPF19 KDR SCAF11 PATJ THRAP3 ANKS1A	5.57e-07	1248	99	21	int:YWHAG
Interaction	VASP interactions	SHROOM3 SPTA1 DCAF8L2 CRTC1 SORBS1 ARFGEF3 NHS PATJ ALG13	1.45e-05	294	99	9	int:VASP
Interaction	YWHAZ interactions	RALGAPA1 ELOA SHROOM3 ZBTB33 SPTA1 SIK1 CRTC1 PARD3B TRIM21 SORBS1 SHANK3 TAB3 PTPN3 PIK3C2B DUSP16 NHS SCAF11 TNS1 ANKS1A	1.96e-05	1319	99	19	int:YWHAZ
Interaction	NEK4 interactions	NBPF8 COL6A3 NBPF12 CPA5 APOB NBPF11 CSMD3 NBPF9 NBPF10 PRPF19 IGSF1 NBPF14	2.82e-05	582	99	12	int:NEK4
Interaction	YWHAE interactions	RALGAPA1 ELOA SHROOM3 ZBTB33 SIK1 CRTC1 PARD3B TRIM21 SORBS1 SHANK3 TAB3 PTPN3 PIK3C2B DUSP16 NHS TTC17 SCAF11 ANKS1A	3.60e-05	1256	99	18	int:YWHAE
Cytoband	1q21.1	NBPF8 NBPF11 NBPF9 NBPF10 NBPF14	2.87e-07	62	102	5	1q21.1
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF12 NBPF26 NBPF11 NBPF9 NBPF10 NBPF14	5.88e-12	23	80	7	662
GeneFamily	UNC13 homologs	UNC13B UNC13A	1.15e-04	4	80	2	836
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	GAK TNS1	5.32e-04	8	80	2	837
GeneFamily	PDZ domain containing	SHROOM3 PARD3B SHANK3 PTPN3 PATJ	5.69e-04	152	80	5	1220
GeneFamily	Collagens	COL6A3 COL8A2 COL10A1	1.10e-03	46	80	3	490
GeneFamily	Immunoglobulin like domain containing	PTPRT KDR ALCAM FCRL5 IGSF1	1.66e-03	193	80	5	594
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN22 PTPN3	2.83e-03	18	80	2	812
GeneFamily	Carboxypeptidases	CPA5 CPA1	3.84e-03	21	80	2	1321
GeneFamily	Adenosine receptors\|V-set domain containing	BTNL3 KDR VSIG8 ALCAM	5.92e-03	163	80	4	590
Coexpression	GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_YOUNG_UP	RALGAPA1 NR4A2 SIK1 PIK3C2B NBPF10 TTC17 PATJ	1.12e-05	198	100	7	M5293
Coexpression	GSE2585_CTEC_VS_THYMIC_DC_UP	COL6A3 EYA4 IRX5 PARD3B ST14 TENM4 ZNF655	1.19e-05	200	100	7	M6271
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FKBP10 CPA5 FAT3 TENM4 KCNG1 TRIM17 PAX7 IGSF1	9.33e-09	181	102	8	47dce04db3392333eb2f7b9b24c32e6740d2d02f
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FKBP10 CPA5 FAT3 TENM4 KCNG1 TRIM17 PAX7 IGSF1	9.33e-09	181	102	8	19103221c3a5a16b16378348004b2c50caee4f01
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FAT3 SPTA1 APOB CSMD3 PKHD1L1 ARFGEF3 TENM4	1.06e-08	184	102	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FAT3 SPTA1 APOB CSMD3 PKHD1L1 ARFGEF3 TENM4	1.06e-08	184	102	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FAT3 SPTA1 APOB CSMD3 PKHD1L1 ARFGEF3 TENM4	1.06e-08	184	102	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EPS8 COL6A3 EYA4 SORBS1 ITGA1 SVEP1 NHS TNS1	1.20e-08	187	102	8	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	UNC13B SHROOM3 EYA4 PARD3B ALCAM PATJ TNS1	1.33e-07	170	102	7	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN SPTA1 CSMD3 PTPRT PAX7 CDH4 UNC13A	1.38e-07	171	102	7	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 SORBS1 ITGA1 SVEP1 PAX7 UNC13A	1.68e-07	176	102	7	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 SORBS1 ITGA1 SVEP1 PAX7 UNC13A	1.68e-07	176	102	7	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B SHROOM3 EYA4 PARD3B ALCAM PATJ TNS1	2.27e-07	184	102	7	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B SHROOM3 EYA4 PARD3B ALCAM PATJ TNS1	2.27e-07	184	102	7	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	UNC13B EPS8 SHROOM3 ARFGEF3 PTPN3 ALCAM PATJ	2.36e-07	185	102	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 SHROOM3 IRX5 ARFGEF3 PTPN3 TENM4 PATJ	2.44e-07	186	102	7	e83718fabb057100835d3357df407f283d23fe16
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPS8 EYA4 PARD3B TEX15 PTPRT NHS KDR	2.63e-07	188	102	7	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RELN ITGA1 PKHD1L1 SHANK3 PTPN3 KDR PLD1	2.63e-07	188	102	7	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D COL6A3 FAT3 ITGA1 SVEP1 TENM4 CDH4	3.25e-07	194	102	7	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B EPS8 SHROOM3 PARD3B ARFGEF3 ALCAM PATJ	3.36e-07	195	102	7	9406866f99555198a9be311fbd65751b70f35446
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EPS8 COL6A3 EYA4 SORBS1 ITGA1 SVEP1 NHS	3.36e-07	195	102	7	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1D FKBP10 COL6A3 EYA4 ITGA1 SVEP1 TENM4	3.60e-07	197	102	7	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	11.5-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	SHROOM3 IRX5 ST14 ARFGEF3 ALCAM PATJ KDF1	3.60e-07	197	102	7	e671af1b69566d97afe97f1a959a07b6f4c05620
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D FKBP10 COL6A3 FAT3 ITGA1 SVEP1 NHS	3.73e-07	198	102	7	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 NBPF26 PTPRT TSBP1 NBPF10 PLD1 NBPF14	3.99e-07	200	102	7	47791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 NBPF26 PTPRT TSBP1 NBPF10 PLD1 NBPF14	3.99e-07	200	102	7	f75d95376a340d467c4392b872b2a2dbdd184556
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 NBPF26 PTPRT TSBP1 NBPF10 PLD1 NBPF14	3.99e-07	200	102	7	fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FKBP10 COL6A3 EYA4 FAT3 NHS IGSF1	1.68e-06	157	102	6	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	RELN ITGA1 PKHD1L1 SHANK3 KDR PLD1	2.40e-06	167	102	6	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	Endothelial-B-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	RELN APOB ITGA1 PKHD1L1 SHANK3 KDR	2.57e-06	169	102	6	8889c9e8af1ab0b093d57b69abd80b59b3461be9
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AKAP6 FAT3 SORBS1 ITGA1 NHS TNS1	2.94e-06	173	102	6	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIK1 PTPN22 FAH TENM4 PIK3C2B FCRL5	3.04e-06	174	102	6	28ec25767bbd4fd898738f9f4d2b585dc91b5adf
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	UNC13B SHROOM3 EYA4 ALCAM PATJ TNS1	3.04e-06	174	102	6	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SIK1 PTPN22 FAH TENM4 PIK3C2B FCRL5	3.69e-06	180	102	6	c12c1cc206f7e63e5722471bd3eb84caddb84129
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GAK SORBS1 ITGA1 SHANK3 KDR TNS1	3.69e-06	180	102	6	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SIK1 PTPN22 FAH TENM4 PIK3C2B FCRL5	3.69e-06	180	102	6	d8135f73a89b97168f2048258f4648e23536ece4
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLCO4A1 SORBS1 ITGA1 SHANK3 PIK3C2B KDR	3.69e-06	180	102	6	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	AKAP6 FAT3 SORBS1 ITGA1 NHS TNS1	3.69e-06	180	102	6	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 IRX5 ARFGEF3 PTPN3 TENM4 PATJ	3.81e-06	181	102	6	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPS8 RELN SVEP1 SP8 KCNG1 CDH4	3.81e-06	181	102	6	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	UNC13B EPS8 SHROOM3 ARFGEF3 ALCAM PATJ	3.81e-06	181	102	6	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 SHROOM3 IRX5 PTPN3 TENM4 PATJ	3.94e-06	182	102	6	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 IRX5 ARFGEF3 PTPN3 TENM4 PATJ	4.06e-06	183	102	6	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EYA4 PTPRT NBPF10 ALCAM PLD1 NBPF14	4.19e-06	184	102	6	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 SHROOM3 IRX5 PTPN3 TENM4 PATJ	4.19e-06	184	102	6	d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EPS8 COL8A2 RELN EYA4 TENM4 NHS	4.33e-06	185	102	6	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN SVEP1 SP8 KCNG1 NHS CDH4	4.33e-06	185	102	6	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	EYA4 CPA5 KCNG1 DUSP16 PAX7 IGSF1	4.33e-06	185	102	6	0094f9baddb20214d2a2c166f1637d1a9cf1169a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B EPS8 SHROOM3 ARFGEF3 ALCAM PATJ	4.46e-06	186	102	6	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	AKAP6 COL6A3 PARD3B SORBS1 ITGA1 NHS	4.60e-06	187	102	6	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPS8 RELN SVEP1 SP8 KCNG1 CDH4	4.60e-06	187	102	6	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	AKAP6 SHROOM3 FAT3 SORBS1 ITGA1 NHS	4.74e-06	188	102	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	UNC13B SHROOM3 ARFGEF3 PTPN3 ALCAM PATJ	4.74e-06	188	102	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 SHROOM3 ARFGEF3 PTPN3 TENM4 PATJ	4.74e-06	188	102	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	UNC13B EPS8 SHROOM3 ARFGEF3 ALCAM PATJ	4.74e-06	188	102	6	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RELN PKHD1L1 SHANK3 PTPN3 KDR PLD1	4.89e-06	189	102	6	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	AKAP6 CACNA1D COL6A3 FAT3 CSMD3 SVEP1	4.89e-06	189	102	6	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	AKAP6 SHROOM3 FAT3 SORBS1 ITGA1 NHS	4.89e-06	189	102	6	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	EPS8 SHROOM3 ARFGEF3 PTPN3 NHS PATJ	4.89e-06	189	102	6	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FKBP10 COL6A3 EYA4 FAT3 FAH IGSF1	5.04e-06	190	102	6	d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 ITGA1 SVEP1 PLD1	5.19e-06	191	102	6	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	UNC13B EPS8 SHROOM3 ARFGEF3 PTPN3 PATJ	5.19e-06	191	102	6	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 EPS8 COL6A3 SORBS1 ITGA1 UNC13A	5.19e-06	191	102	6	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 ITGA1 SVEP1 PLD1	5.19e-06	191	102	6	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1D COL6A3 FAT3 PARD3B ITGA1 SVEP1	5.19e-06	191	102	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 ITGA1 SVEP1 PLD1	5.35e-06	192	102	6	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1D COL6A3 FAT3 PARD3B ITGA1 SVEP1	5.35e-06	192	102	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 ITGA1 SVEP1 PLD1	5.35e-06	192	102	6	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	CACNA1D COL6A3 COL10A1 FAT3 ITGA1 SVEP1	5.35e-06	192	102	6	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1D COL6A3 FAT3 PARD3B SVEP1 CDH4	5.51e-06	193	102	6	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1D COL6A3 EYA4 ITGA1 TENM4 NHS	5.51e-06	193	102	6	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D SHROOM3 PARD3B PTPN3 NHS PATJ	5.51e-06	193	102	6	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN PKHD1L1 SHANK3 KDR TNS1 ANKS1A	5.51e-06	193	102	6	bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B SHROOM3 LMTK2 ARFGEF3 ALCAM PATJ	5.51e-06	193	102	6	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D COL6A3 FAT3 ITGA1 CSMD3 SVEP1	5.68e-06	194	102	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B SHROOM3 PARD3B ARFGEF3 ALCAM PATJ	5.68e-06	194	102	6	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B EPS8 SHROOM3 LMTK2 ARFGEF3 PATJ	5.68e-06	194	102	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	Adult-Endothelial\|Adult / Lineage, Cell type, age group and donor	RELN SLCO4A1 ITGA1 PKHD1L1 SHANK3 KDR	5.68e-06	194	102	6	963b3fbee0575af8379baa397ace65949eaf34f7
ToppCell	Children_(3_yrs)-Endothelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RELN SORBS1 ITGA1 PKHD1L1 SHANK3 KDR	5.85e-06	195	102	6	094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCell	facs-GAT-Fat-3m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 RELN SORBS1 ITGA1 SHANK3 KDR	6.02e-06	196	102	6	b6cc1f466d45479764080d34b1daeb8243a5a9f3
ToppCell	facs-GAT-Fat-3m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 RELN SORBS1 ITGA1 SHANK3 KDR	6.02e-06	196	102	6	ede6104cdfa4ee5287efcca9bbc36677cbf7a8d8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 FAT3 PARD3B ST14 PTPN3 PATJ	6.02e-06	196	102	6	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	facs-GAT-Fat-3m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM182 RELN SORBS1 ITGA1 SHANK3 KDR	6.02e-06	196	102	6	039044ab28c53391c34d8226fb8cf78549e63ef4
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B SHROOM3 IRX5 ST14 ARFGEF3 PATJ	6.02e-06	196	102	6	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1D COL6A3 FAT3 PARD3B ITGA1 SVEP1	6.02e-06	196	102	6	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 SORBS1 ITGA1 SVEP1	6.20e-06	197	102	6	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 SORBS1 ITGA1 SVEP1	6.20e-06	197	102	6	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	nucseq-Endothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RELN SORBS1 ITGA1 PKHD1L1 SHANK3 KDR	6.20e-06	197	102	6	ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 SORBS1 ITGA1 SVEP1	6.20e-06	197	102	6	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1D COL6A3 FAT3 PARD3B CSMD3 SVEP1	6.20e-06	197	102	6	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1D COL6A3 FAT3 PARD3B SVEP1 CDH4	6.20e-06	197	102	6	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	wk_15-18-Epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	UNC13B SHROOM3 IRX5 ST14 ALCAM PATJ	6.38e-06	198	102	6	12bbe77c3d68bf1e545949dbb1eb49ed3641de3d
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B SHROOM3 IRX5 ARFGEF3 ALCAM PATJ	6.38e-06	198	102	6	5fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 COL6A3 EYA4 SORBS1 ITGA1 SVEP1	6.38e-06	198	102	6	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1D COL6A3 FAT3 PARD3B ITGA1 SVEP1	6.38e-06	198	102	6	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B SHROOM3 IRX5 ARFGEF3 ALCAM PATJ	6.38e-06	198	102	6	6ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCell	COVID-19-lung-Capillary_2\|lung / Disease (COVID-19 only), tissue and cell type	SLCO4A1 SORBS1 ITGA1 SHANK3 PIK3C2B KDR	6.57e-06	199	102	6	793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell	Bronchial-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RELN SLCO4A1 ITGA1 PKHD1L1 SHANK3 KDR	6.57e-06	199	102	6	36a230b80096455df26c2e2c8c05fd6b231508c5
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	CACNA1D FKBP10 COL6A3 FAT3 ITGA1 SVEP1	6.57e-06	199	102	6	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RELN SLCO4A1 ITGA1 PKHD1L1 SHANK3 KDR	6.57e-06	199	102	6	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	UNC13B ZC3H12B SORBS1 ITGA1 SHANK3 TNS1	6.76e-06	200	102	6	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	EPS8 NR4A2 SORBS1 ITGA1 ALCAM TNS1	6.76e-06	200	102	6	2bc7f462a551292de2501028164573935232f899
Drug	Pesticides	NBPF8 CACNA1D NBPF12 NBPF11 NBPF9 NBPF10 NHS NBPF14	2.81e-07	150	98	8	ctd:D010575
Drug	5230742; Up 200; 17uM; MCF7; HT_HG-U133A_EA	AKAP6 CACNA1D CRTC1 TRIM21 AP4E1 KCNG1 TTC17 ALG13	1.97e-06	194	98	8	862_UP
Disease	schizophrenia (implicated_via_orthology)	CACNA1D RELN NR4A2 CSMD3 SHANK3	2.76e-06	68	95	5	DOID:5419 (implicated_via_orthology)
Disease	methadone dose measurement	EYA4 CRTC1 TEX15 PATJ	4.87e-05	62	95	4	EFO_0007907
Disease	mean platelet volume	PCDHGA6 SPTA1 PAQR8 CRTC1 SORBS1 SHANK3 SVEP1 FAH SP8 DDHD1 MICA ANKS1A	1.07e-04	1020	95	12	EFO_0004584
Disease	coronary artery disease	COL6A3 SHROOM3 APOB ITGA1 SVEP1 AP4E1 SP8 SCAF11 ALCAM KDF1 TNS1 UNC13A ANKS1A	1.17e-04	1194	95	13	EFO_0001645
Disease	Manic	CACNA1D RELN SHANK3 TENM4	1.20e-04	78	95	4	C0338831
Disease	response to angiotensin receptor blocker	CACNA1D EPS8 DUSP16	1.23e-04	30	95	3	EFO_0010735
Disease	Graves disease	PTPN22 TSBP1 MICA ANKS1A	1.39e-04	81	95	4	EFO_0004237
Disease	otosclerosis	RELN IRX5 CRTC1 KDR	1.39e-04	81	95	4	EFO_0004213
Disease	persistent Staphylococcus aureus carrier status	SORBS1 PTPN3	1.53e-04	6	95	2	EFO_0007757
Disease	visceral adipose tissue measurement	AKAP6 CRTC1 PARD3B PIK3C2B TSBP1 ALCAM PATJ ANKS1A	1.66e-04	481	95	8	EFO_0004765
Disease	chronic obstructive pulmonary disease	AKAP6 CACNA1D COL6A3 PAQR8 CRTC1 ITGA1 TENM4 TSBP1 TNS1	3.82e-04	688	95	9	EFO_0000341
Disease	Colorectal Carcinoma	AKAP6 UNC13B EYA4 NR4A2 APOB CSMD3 PTPRT KDR KDF1	4.41e-04	702	95	9	C0009402
Disease	diffuse plaque measurement	COL6A3 RELN SHROOM3 CSMD3 ARFGEF3 TENM4 KCNG1 KDR TNS1	7.63e-04	758	95	9	EFO_0010699
Disease	cortical surface area measurement	RELN SHROOM3 FAT3 PARD3B SVEP1 SP8 USP38 MICA ALCAM PAX7 TNS1 ANKS1A	1.27e-03	1345	95	12	EFO_0010736
Disease	Muscle hypotonia	RALGAPA1 PAX7	1.35e-03	17	95	2	C0026827
Disease	autoimmune thyroid disease, type 1 diabetes mellitus	PTPN22 MICA	1.52e-03	18	95	2	EFO_0006812, MONDO_0005147
Disease	Manic Disorder	CACNA1D RELN TENM4	1.58e-03	71	95	3	C0024713
Disease	diet measurement, HOMA-B	FAT3 DUSP16	1.69e-03	19	95	2	EFO_0004469, EFO_0008111
Disease	hemifacial microsomia	SHROOM3 PARD3B	1.69e-03	19	95	2	MONDO_0015398
Disease	C-reactive protein measurement	AKAP6 APOB ITGA1 PTPN3 ZNF655 SCAF11 VSIG8 PATJ KDF1 CDH4 ANKS1A	1.72e-03	1206	95	11	EFO_0004458
Disease	visual cortical surface area measurement	ALCAM PAX7	1.88e-03	20	95	2	EFO_0004771
Disease	Autoimmune Hepatitis	TSBP1 MICA	2.07e-03	21	95	2	EFO_0005676
Disease	vital capacity	COL6A3 SHROOM3 EYA4 NBPF12 APOB SVEP1 PIK3C2B KDR PATJ TNS1 ANKS1A	2.08e-03	1236	95	11	EFO_0004312
Disease	Depression, Bipolar	CACNA1D RELN TENM4	2.14e-03	79	95	3	C0005587
Disease	Mood Disorders	CACNA1D RELN CRTC1 PROKR2	2.16e-03	168	95	4	C0525045
Disease	body weight	AKAP6 UNC13B RALGAPA1 RELN NR4A2 CRTC1 PARD3B PTPRT SP8 MICA PATJ	2.43e-03	1261	95	11	EFO_0004338
Disease	Autism Spectrum Disorders	RELN SHANK3 DDHD1	2.64e-03	85	95	3	C1510586
Disease	alpha-2-macroglobulin receptor-associated protein measurement	TSBP1 MICA	2.70e-03	24	95	2	EFO_0008021
Disease	cortical thickness	AKAP6 RELN SHROOM3 EYA4 FAT3 SP8 ALCAM PAX7 TNS1 ANKS1A	3.11e-03	1113	95	10	EFO_0004840
Disease	major depressive disorder, COVID-19	PTPRT CXCR6	3.17e-03	26	95	2	MONDO_0002009, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
AYYAHTTASTNVSAS	UNC13A	906	Q9UPW8
SSDSRANADGYSLYD	BTNL3	176	Q6UXE8
SSSGHYDSVYSKQFQ	ALG13	341	Q9NP73
YHEDYGFSSFNDSSQ	CXCR6	6	O00574
FSTTHETSLYFHSDY	CSMD3	2191	Q7Z407
TYVTHSVSYGQDTSF	ADGRG4	1401	Q8IZF6
ARSTDTFNYATYHTL	CPA1	111	P15085
DYVHSFLSSGYSSID	ANKS1A	786	Q92625
SSFSSLSNVAYEDDY	AP4E1	816	Q9UPM8
AAAFSSYVGSPYDHT	IRX5	76	P78411
STSLFSYYNSHDSLS	PTPN22	571	Q9Y2R2
SYAVQSHFGDYNSSI	PTPN3	151	P26045
AYGARHSFSSYSDSF	PAX7	351	P23759
STRSSQHFYYDGELF	MICA	126	Q29983
DYSHSSGVDSAVYFP	PARD3B	671	Q8TEW8
ISTSANLDYEDSSFY	PCDHGA6	301	Q9Y5G7
SEVEANYHCSLYSSS	IGLV2-33	101	A0A075B6J2
SASSTYFHQLFSVAG	ZBTB33	51	Q86T24
ASTSSTYNFTHYDRI	HPS4	596	Q9NQG7
IYLFNSSHSDGAQYS	DCAF8L2	446	P0C7V8
TNSFSYSSYHTLEEI	CPA5	131	Q8WXQ8
FSLTAEHSGNYYCTA	FCRL5	436	Q96RD9
SFSFSLTEGHSGNYY	FCRL5	526	Q96RD9
SQGSYRDSAYFSDND	LMTK2	1096	Q8IWU2
GDNSDYDYSALSCTS	KCNG1	6	Q9UIX4
YDYSALSCTSDASFH	KCNG1	11	Q9UIX4
QAGSALANYIHFSSY	GPR180	216	Q86V85
QFYSSASEYHISIAA	ITGA1	951	P56199
YYFSSSGFQADFHEL	GPR42	276	O15529
SSYHNFYSIRGAEVS	RELN	721	P78509
SYRNASSLDSLHYFA	PTPRT	651	O14522
ATSYEDFYLSCSLSH	PIK3C2B	646	O00750
SASGSLYAVNSFDYE	PCDHAC2	526	Q9Y5I4
SENGYYLATAADDSS	PRPF19	401	Q9UMS4
YGSALAHFFYSSDQA	PAQR8	156	Q8TEZ7
DFGSATTISHYPDYS	GAK	191	O14976
TYDHKNTFTLSYDGS	APOB	1411	P04114
LSTYSFATDGFHAAA	EYA4	446	O95677
TLFDSSYSRNHTYNT	FKBP10	301	Q96AY3
YYLDSTPFAASNHSD	IGSF1	1136	Q8N6C5
SSRNDYIHSGLYSSF	ELK4	136	P28324
YSSDPESSDYGHVQS	ELOA	191	Q14241
HTSTLGSVFGDAYYE	CRTC1	476	Q6UUV9
DTGSEHSTAYRFLSY	CPHXL2	206	A0A1W2PPK0
SYGSRYSESNFSVDD	ARFGEF3	586	Q5TH69
QANGLYSTEYIHSSF	COL8A2	681	P25067
SLHGFSSSEDALEYY	DUSP16	416	Q9BY84
DNYHTSFLFGLSTSQ	DUSP16	511	Q9BY84
TESSHFYSASAIYGG	DUSP16	561	Q9BY84
SALSYVYANHFTEAG	COL6A3	721	P12111
YNSTDYFHIDSSSGL	FAT3	2331	Q8TDW7
YYFSSSGFQADFHEL	FFAR3	276	O14843
SSLNSSSSGDQDYDY	CDH4	881	P55283
SVSEYHPADGYAFSS	EPS8	481	Q12929
YAFSSNIYTRGSHLD	EPS8	491	Q12929
IGDYTDFYSSRQHAT	FAH	121	P16930
FSSAESGSSLRYYSE	DDHD1	91	Q8NEL9
SVSHSGESSFTYRAY	SCAF11	196	Q99590
SPSFSSLHYQDAGNY	ALCAM	376	Q13740
SHSFRNTILGYFDYA	CACNA1D	911	Q01668
LSYTSSSGDDDFSFY	DCAF15	91	Q66K64
FAFLETYGTHYSSSG	C9	336	P02748
GHSTAYHFLSYNSAE	CPHXL	236	A0A1W2PPM1
SPASQSYSYHSSGEY	NR4A2	16	P43354
SYSYHSSGEYSSDFL	NR4A2	21	P43354
YQRSSSSGSDDYAYT	TAB3	501	Q8N5C8
ADTSSHFSVDTEGYY	NHS	771	Q6T4R5
ASYQSYSSTFHSLEE	NBPF8	541	Q3BBV2
ASYKSYSSTFHSLEE	NBPF9	576	P0DPF3
ASYQSYSSTFHSLEE	NBPF10	576	Q6P3W6
ASYQSYSSTFHSLEE	NBPF11	576	Q86T75
LASYQSYSSTFHSLE	NBPF12	846	Q5TAG4
ASYKSYSSTFHSLEE	NBPF14	236	Q5TI25
ASYKSYSSTFHSLEE	NBPF26	236	B4DH59
SISSIDSTSSYFNHY	PLD1	576	Q13393
AFSAHSYTSNLGDYD	SIK1B	291	A0A0B4J2F2
AFSAHSYTSNLGDYD	SIK1	291	P57059
SSSTSDLSNYDHAYL	SHROOM3	196	Q8TF72
FASSPRGSEEYYSFH	KDF1	206	Q8NAX2
HSADDFYAGSTVTYQ	SVEP1	1701	Q4LDE5
YNSDYSGLSHSAFSS	SP8	251	Q8IXZ3
DLHSYQSGLIASSYD	SLCO4A1	136	Q96BD0
KGDFYSYLSLSSHDS	AKAP6	2106	Q13023
GLYSSEYVHSSFSGF	COL10A1	661	Q03692
SSSSQSSHSYKAEEY	THRAP3	781	Q9Y2W1
YHSELSYQESFHSSI	VSIG8	201	P0DPA2
SSDSHSDSFSAFQYD	RALGAPA1	906	Q6GYQ0
DFLGSSSGYSSEDDY	SUN2	126	Q9UH99
YTVGSYDSLTSHSDY	SHANK3	551	Q9BYB0
ASSYHSTDADFTGYG	PATJ	1401	Q8NI35
TVRFHSDQSYTDTGF	ST14	426	Q9Y5Y6
SDQSYTDTGFLAEYL	ST14	431	Q9Y5Y6
TDTGFLAEYLSYDSS	ST14	436	Q9Y5Y6
SSETPGYIYSSNFHA	SORBS1	646	Q9BX66
GSSYSSPDYSLQHFS	TNS1	1141	Q9HBL0
LYNHSSSEITSLYYD	TENM4	2326	Q6N022
ASSLSFNFSYGDYDL	PROKR2	21	Q8NFJ6
YYAHTTASTNVSASD	UNC13B	831	O14795
RSHLSGYDYVGFTNS	SPTA1	2401	P02549
AYHSANANSYFSSPT	PKHD1L1	431	Q86WI1
HAALDDSDFFTSYYT	TTC17	286	Q96AE7
YNITDHGSLIYSFSE	TRIM21	421	P19474
GHYYSYARNITSTDS	USP38	856	Q8NB14
TTDSYGYHSYPLSNS	ZC3H12B	736	Q5HYM0
SQDGFLSSSTNYYNH	nan	21	Q6ZVL8
FYSVSDGSHLHTYSQ	TRIM17	431	Q9Y577
YECNEYEGSFSHSSD	ZNF655	436	Q8N720
QSGYHSDDTDTTVYS	KDR	1306	P35968
NSSEHLFGTSYPYSA	TEX15	2646	Q9BXT5
GSRHAYSTQSDTSYD	TSBP1	56	Q5SRN2
HNSTSYDSAVIYRGF	TMEM182	101	Q6ZP80
FGYDSFLTQHTSTYT	ZNF606	381	Q8WXB4