Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR65 OR2B2 GPR37L1 OR5K4 OR5K3 GPR87 PTAFR OR11H12 GPR160 FZD6 CELSR3 OR4A8 OR11H1 OR10G3 GPR68 OR6C1 P2RY14 OR11H2	6.87e-05	884	144	18	GO:0004930
GeneOntologyMolecularFunction	G protein-coupled purinergic nucleotide receptor activity	GPR87 PTAFR P2RY14	9.96e-05	13	144	3	GO:0045028
Domain	Pan_app	MST1 MST1L KLKB1	1.50e-05	7	143	3	IPR003609
Domain	PAN	MST1 MST1L KLKB1	1.50e-05	7	143	3	PS50948
Domain	PAN_1	MST1 MST1L KLKB1	1.50e-05	7	143	3	PF00024
Domain	Dopey_N	DOP1A DOP1B	5.82e-05	2	143	2	PF04118
Domain	Dopey_N	DOP1A DOP1B	5.82e-05	2	143	2	IPR007249
Domain	P2Y13_rcpt	GPR87 P2RY14	1.74e-04	3	143	2	IPR008109
Domain	GPCR_Rhodpsn_7TM	GPR65 OR2B2 GPR37L1 OR5K4 OR5K3 GPR87 PTAFR OR11H12 GPR160 OR11H1 OR10G3 GPR68 OR6C1 P2RY14 OR11H2	1.96e-04	670	143	15	IPR017452
Domain	G_PROTEIN_RECEP_F1_2	GPR65 OR2B2 GPR37L1 OR5K4 OR5K3 GPR87 PTAFR OR11H12 GPR160 OR11H1 OR10G3 GPR68 OR6C1 P2RY14 OR11H2	2.73e-04	691	143	15	PS50262
Domain	GPCR_Rhodpsn	GPR65 OR2B2 GPR37L1 OR5K4 OR5K3 GPR87 PTAFR OR11H12 GPR160 OR11H1 OR10G3 GPR68 OR6C1 P2RY14 OR11H2	2.77e-04	692	143	15	IPR000276
Domain	-	GTF2IRD2B GTF2IRD2	3.46e-04	4	143	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	3.46e-04	4	143	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	3.46e-04	4	143	2	PF02946
Domain	GTF2I	GTF2IRD2B GTF2IRD2	3.46e-04	4	143	2	IPR004212
Domain	PAN_AP	MST1 MST1L	5.73e-04	5	143	2	SM00473
Domain	G_PROTEIN_RECEP_F1_1	GPR65 OR2B2 GPR37L1 OR5K4 OR5K3 GPR87 PTAFR OR11H12 GPR160 OR11H1 OR10G3 GPR68 OR6C1 P2RY14	7.92e-04	685	143	14	PS00237
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF8 NBPF20 NBPF19 NBPF9 NBPF10 NBPF14	3.37e-10	21	153	6	16079250
Pubmed	Identification of a melanoma susceptibility locus and somatic mutation in TET2.	DOCK3 TET2 EYS	2.88e-06	7	153	3	24980573
Pubmed	Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.	TET2 MYD88 TLR7	4.60e-06	8	153	3	36539616
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ABCA2 WASHC4 TRIM35 AAK1 MINAR1 DOP1A	6.99e-06	104	153	6	10470851
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF9 NBPF14	9.79e-06	10	153	3	22973535
Pubmed	Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.	GPR65 GPR68	1.92e-05	2	153	2	19234222
Pubmed	Myd88-dependent toll-like receptor 7 signaling mediates protection from severe Ross River virus-induced disease in mice.	MYD88 TLR7	1.92e-05	2	153	2	22837203
Pubmed	TLR7 agonism accelerates disease in a mouse model of primary Sjögren's syndrome and drives expansion of T-bet+ B cells.	MYD88 TLR7	1.92e-05	2	153	2	36591307
Pubmed	Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein.	MST1 KLKB1	1.92e-05	2	153	2	10068459
Pubmed	TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice.	MYD88 TLR7	1.92e-05	2	153	2	22837197
Pubmed	Recognition of single-stranded RNA viruses by Toll-like receptor 7.	MYD88 TLR7	1.92e-05	2	153	2	15034168
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	1.92e-05	2	153	2	8393443
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	1.92e-05	2	153	2	27609031
Pubmed	PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.	PDS5B PDS5A	1.92e-05	2	153	2	31757807
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	1.92e-05	2	153	2	24980820
Pubmed	Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.	MYD88 TLR7	1.92e-05	2	153	2	14976261
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	1.92e-05	2	153	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	1.92e-05	2	153	2	16961763
Pubmed	Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease.	MYD88 TLR7	1.92e-05	2	153	2	23497717
Pubmed	The co-stimulatory effects of MyD88-dependent Toll-like receptor signaling on activation of murine γδ T cells.	MYD88 TLR7	1.92e-05	2	153	2	25232836
Pubmed	PDS5A and PDS5B in Cohesin Function and Human Disease.	PDS5B PDS5A	1.92e-05	2	153	2	34070827
Pubmed	Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway.	MYD88 TLR7	1.92e-05	2	153	2	21482736
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	1.92e-05	2	153	2	39253972
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	1.92e-05	2	153	2	32017081
Pubmed	Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery.	MYD88 TLR7	1.92e-05	2	153	2	22421433
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	1.92e-05	2	153	2	24409221
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	1.92e-05	2	153	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	1.92e-05	2	153	2	9486989
Pubmed	A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways.	MYD88 TLR7	1.92e-05	2	153	2	23845800
Pubmed	DNA methylcytosine dioxygenase ten-eleven translocation 2 enhances lipopolysaccharide-induced cytokine expression in human dental pulp cells by regulating MyD88 hydroxymethylation.	TET2 MYD88	1.92e-05	2	153	2	29654353
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	1.92e-05	2	153	2	33887258
Pubmed	Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.	DOP1A DOP1B	1.92e-05	2	153	2	10931277
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	1.92e-05	2	153	2	25938541
Pubmed	AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.	GAK AAK1	1.92e-05	2	153	2	25653444
Pubmed	Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.	GPR65 GPR68	1.92e-05	2	153	2	26550826
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	1.92e-05	2	153	2	29760744
Pubmed	Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions.	MYD88 PTAFR	1.92e-05	2	153	2	21109237
Pubmed	PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.	PDS5B PDS5A	1.92e-05	2	153	2	35986423
Pubmed	Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.	RNF213 RNF123	1.92e-05	2	153	2	26126547
Pubmed	Toll-like receptors control autophagy.	MYD88 TLR7	1.92e-05	2	153	2	18337753
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	1.92e-05	2	153	2	31206688
Pubmed	Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells.	TET2 GDF11	1.92e-05	2	153	2	37801347
Pubmed	Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand.	MYD88 TLR7	1.92e-05	2	153	2	22619481
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	1.92e-05	2	153	2	30708325
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	1.92e-05	2	153	2	27696525
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	1.92e-05	2	153	2	15388857
Pubmed	Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.	RNF213 RNF123	1.92e-05	2	153	2	33973242
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MYD88 CPAMD8 RHBDF2 TRIO NAIP AAK1 RNF213 G2E3 ARHGEF16 CASZ1 KRCC1 IGF2 NT5C2 GPR137B IFT122 MCF2L RECK KDM4B DOP1A	3.16e-05	1489	153	19	28611215
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 DAB2IP DOCK3 ABCA2 CLTCL1 RHBDF2 TRIO POLE GRK5 CASZ1 RGMA CELSR3 MTMR14 IL17RE ZNF335 MCF2L	3.16e-05	1105	153	16	35748872
Pubmed	Association analysis of 3p21 with Crohn's disease in a New Zealand population.	DOCK3 MST1 RNF123	5.43e-05	17	153	3	20307617
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	5.75e-05	3	153	2	10225971
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	5.75e-05	3	153	2	38430683
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	5.75e-05	3	153	2	26698664
Pubmed	TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG.	MYD88 TLR7	5.75e-05	3	153	2	30455267
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	5.75e-05	3	153	2	17395874
Pubmed	Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.	MYD88 TLR7	5.75e-05	3	153	2	25229618
Pubmed	Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.	MYD88 TLR7	5.75e-05	3	153	2	21115693
Pubmed	Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-κB Signaling Pathways via TLR7.	MYD88 TLR7	5.75e-05	3	153	2	39273091
Pubmed	Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.	GPR65 GPR68	5.75e-05	3	153	2	34460096
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	5.75e-05	3	153	2	27496379
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	5.75e-05	3	153	2	12606483
Pubmed	Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.	MYD88 TLR7	5.75e-05	3	153	2	11812998
Pubmed	The evolution and mechanism of GPCR proton sensing.	GPR65 GPR68	5.75e-05	3	153	2	33478938
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	5.75e-05	3	153	2	36623453
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	5.75e-05	3	153	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	5.75e-05	3	153	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	5.75e-05	3	153	2	25049204
Pubmed	Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.	PDS5B PDS5A	5.75e-05	3	153	2	28343969
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	5.75e-05	3	153	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	5.75e-05	3	153	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	5.75e-05	3	153	2	35525373
Pubmed	Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection.	MYD88 TLR7	5.75e-05	3	153	2	21625574
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	5.75e-05	3	153	2	27510910
Pubmed	Toll-like receptor 7 controls the anti-retroviral germinal center response.	MYD88 TLR7	5.75e-05	3	153	2	21998589
Pubmed	Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.	MST1 MST1L	5.75e-05	3	153	2	38898027
Pubmed	WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.	MST1 MST1L	5.75e-05	3	153	2	32045478
Pubmed	Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.	MST1 MST1L	5.75e-05	3	153	2	27940445
Pubmed	Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7.	MYD88 TLR7	5.75e-05	3	153	2	34211474
Pubmed	MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock.	MYD88 TLR7	5.75e-05	3	153	2	29049365
Pubmed	MyD88-Dependent Signaling Is Required for HOIP Deficiency-Induced Autoinflammation.	MYD88 RNF31	5.75e-05	3	153	2	34253576
Pubmed	The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.	GPR65 GPR68	5.75e-05	3	153	2	33057165
Pubmed	An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.	MYD88 TLR7	5.75e-05	3	153	2	22610069
Pubmed	Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila.	MYD88 NAIP	5.75e-05	3	153	2	20351139
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	5.75e-05	3	153	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	5.75e-05	3	153	2	19339990
Pubmed	Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.	GPR65 GPR68	5.75e-05	3	153	2	15665078
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	5.75e-05	3	153	2	30063115
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	5.75e-05	3	153	2	27218122
Pubmed	The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.	MYD88 TLR7	5.75e-05	3	153	2	18820679
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	5.75e-05	3	153	2	24852423
Pubmed	Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7.	MYD88 TLR7	5.75e-05	3	153	2	22745379
Pubmed	Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.	PDS5B PDS5A	5.75e-05	3	153	2	24141881
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	5.75e-05	3	153	2	12804176
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	5.75e-05	3	153	2	15100712
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	5.75e-05	3	153	2	37184367
Pubmed	Role of Toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle.	MYD88 TLR7	5.75e-05	3	153	2	24368419
Pubmed	Myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease.	MYD88 TLR7	5.75e-05	3	153	2	31048358
Pubmed	The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.	MYD88 TLR7	5.75e-05	3	153	2	25848864
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	5.75e-05	3	153	2	31976559
Pubmed	Taking the next step forward - Diagnosing inherited infantile cholestatic disorders with next generation sequencing.	NPC1 PKHD1	5.75e-05	3	153	2	25771912
Cytoband	1q21.1	NBPF8 NBPF9 NBPF10 NBPF14	5.69e-05	62	153	4	1q21.1
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF26 NBPF20 NBPF19 NBPF9 NBPF10 NBPF14	3.60e-11	23	103	7	662
GeneFamily	G protein-coupled receptors, Class A orphans	GPR65 GPR37L1 GPR87 GPR160 GPR68	8.26e-05	78	103	5	262
GeneFamily	Olfactory receptors, family 11	OR11H12 OR11H1 OR11H2	2.93e-04	23	103	3	159
GeneFamily	Ring finger proteins	RAD18 RNF31 TRIM35 RNF213 RNF123 RNF125 TOPORS	9.98e-04	275	103	7	58
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TPMT GPR65 POLE PTAFR GPR160 CENPI TONSL NT5C2	1.43e-07	171	153	8	bf475a69db04d4a886e442704955c6a96ff0de46
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK3 CACNA1B POLE SLC7A9 OTOGL PKHD1 KLKB1	1.50e-06	162	153	7	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	distal-3-Hematologic-Basophil/Mast_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPR65 PLEKHF2 LRRC70 MALRD1 CELSR3 P2RY14 KLKB1	4.79e-06	193	153	7	23c6c798525dad43eff792727902ea562bf373be
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRIB2 TRIO BEND5 FZD6 IGF2 ZDHHC23 FBLIM1	4.79e-06	193	153	7	efa91167dc7a59bf32addf90ffb7bf070b2a0151
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRIB2 TRIO GPR37L1 ITGA7 RGMA MALRD1 NBPF10	4.95e-06	194	153	7	68d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 CACNA1B POLE SLC7A9 OTOGL PKHD1	1.10e-05	145	153	6	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	Tracheal-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MATN3 ITGA7 CHST8 P2RY14	2.23e-05	48	153	4	0b71435d798c6b25089a16b25d1d535f3c780d30
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 NR6A1 MST1 TBC1D13 PRDM8 PLCL1	2.30e-05	165	153	6	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	BAL-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	MCM6 TONSL LBH IFT122 FHL2 GDF11	2.46e-05	167	153	6	6c5aa9077ae7eb8887269d405972bd5b31596b19
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	POLE G2E3 TLR7 TONSL P2RY14 DOP1B	2.46e-05	167	153	6	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 RAD18 POLE CAV3 SLC12A3 CENPI	2.63e-05	169	153	6	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CMTR1 POLE LINC00528 NBPF9 ZNF335 FBLIM1	2.63e-05	169	153	6	ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	TET2 WASHC4 NUP205 KLHDC1 ZDHHC23 DOP1A	3.00e-05	173	153	6	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 NBEAL1 ZNF423 ITGA7 OTOGL LBH	3.20e-05	175	153	6	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 NBEAL1 ZNF423 ITGA7 OTOGL LBH	3.20e-05	175	153	6	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA7 CLSTN1 CHST8 RGMA P2RY14 PLCL1	3.63e-05	179	153	6	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	COVID-19_Convalescent\|World / Disease condition and Cell class	KLF6 NBPF26 BCKDHA NBPF20 NBPF19 NBPF14	3.86e-05	181	153	6	a62115a8da486fc61225901c72b1ec70bcaf4c36
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 ARHGEF16 DNALI1 RHOV IL17RE PKHD1	4.23e-05	184	153	6	6388c47b7f1d8203e3069eba0e74107256dcae51
ToppCell	droplet-Heart-4Chambers-18m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 ARHGEF16 DNALI1 RHOV IL17RE PKHD1	4.23e-05	184	153	6	d83ae1dc64aa1b27d3b524c137567418cc0ff8c6
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	GAK CASZ1 NUDT6 TADA2B KDM4B	4.26e-05	112	153	5	518b7ab98b988b23f3d0f0e1f4fe90a7068f9d87
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA7 ARHGEF16 IL17RE LBH P2RY14 PLCL1	4.63e-05	187	153	6	dba4924d914a7dcd4901142684ba920c2404860b
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA7 ARHGEF16 IL17RE LBH P2RY14 PLCL1	4.63e-05	187	153	6	9688141beef4f62613d7a810c5872ccb9afc1a71
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	TET2 NAIP NBPF26 NBPF19 NBPF10 NBPF14	4.91e-05	189	153	6	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B NR6A1 XKR6 NALF1 SLC12A3 PKHD1	4.91e-05	189	153	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B XKR6 CASZ1 NALF1 SLC12A3 PKHD1	4.91e-05	189	153	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPC1 FNDC3B TRIO KLF6 NALF1 FHL2	4.91e-05	189	153	6	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPC1 FNDC3B TRIO KLF6 NALF1 FHL2	4.91e-05	189	153	6	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF423 GPR37L1 NBPF26 ITGA7 RGMA NBPF10	5.05e-05	190	153	6	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	NAIP ZNF318 CHMP7 RNF123 NBPF14 XPOT	5.05e-05	190	153	6	2434b8ad2976eab7d9147012c28454ab29670709
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	BEND5 PLEKHF2 EFCAB13 GPR160 LBH P2RY14	5.05e-05	190	153	6	e63945fa1dcd58bee129f1dd0c23b64a76241554
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	BEND5 PLEKHF2 EFCAB13 GPR160 LBH P2RY14	5.05e-05	190	153	6	fa65bc5a178ae0c80a9bd4b282e4539493128a64
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDS5B RAD18 POLE CAV3 CENPI TONSL	5.05e-05	190	153	6	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RHBDF2 NAIP ZNF318 RNF123 NBPF14 XPOT	5.20e-05	191	153	6	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 FNDC3B TRIO NR6A1 PKHD1 FHL2	5.20e-05	191	153	6	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 FNDC3B TRIO NR6A1 PKHD1 FHL2	5.20e-05	191	153	6	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF423 GPR37L1 NBPF26 ITGA7 RGMA NBPF10	5.36e-05	192	153	6	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF423 GPR37L1 NBPF26 ITGA7 RGMA NBPF10	5.36e-05	192	153	6	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	distal-Hematologic-Basophil/Mast_2-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPR65 LRRC70 MALRD1 CELSR3 P2RY14 KLKB1	5.51e-05	193	153	6	f22d0a2ea6bbdd625909ccb6a89aca89ab670306
ToppCell	distal-Hematologic-Basophil/Mast_2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPR65 LRRC70 MALRD1 CELSR3 P2RY14 KLKB1	5.51e-05	193	153	6	dcdc1498726c68bf590bf84cb81e5f7fb7ba4d78
ToppCell	5'\|World / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLF6 DIABLO ZNF862 NBPF26 BCKDHA IGF2	5.67e-05	194	153	6	7f98f8bfd17a762a2bf748f1c689c7e941793917
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B TRIO RNF213 XKR6 PTAFR PKHD1	5.84e-05	195	153	6	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MYD88 CMTR1 RNF213 TLR7 CASZ1 DOP1A	5.84e-05	195	153	6	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B TRIO RNF213 XKR6 PTAFR PKHD1	5.84e-05	195	153	6	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Pericytes\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CHCHD10 TRIB2 ITGA7 LBH P2RY14 DNAH11	6.18e-05	197	153	6	608328608cef82adc867a449216839622253d486
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DOCK3 AAK1 CLSTN1 NALF1 CELSR3 RHOV	6.53e-05	199	153	6	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	mLN-(2)_B_cell-(23)_Follicular_B_cell\|mLN / shred on region, Cell_type, and subtype	BEND5 PLEKHF2 ZNF318 GPR160 P2RY14 KDM4B	6.71e-05	200	153	6	659b49eeeb3e96b0a52663e60336ca4d76c83cfc
ToppCell	mLN-B_cell-Follicular_B_cell\|mLN / Region, Cell class and subclass	BEND5 PLEKHF2 ZNF318 GPR160 P2RY14 KDM4B	6.71e-05	200	153	6	7f5dbd06f8643230dba45d6fa0258a13cb71f681
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	ZBTB38 TRIB2 NBEAL1 P2RY14 PLCL1 FBLIM1	6.71e-05	200	153	6	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Caecum-B_cell-Follicular_B_cell\|Caecum / Region, Cell class and subclass	BEND5 PLEKHF2 ZNF318 CHMP7 LBH P2RY14	6.71e-05	200	153	6	5908e598c248ab89e576750767e9502385ee6322
ToppCell	Caecum-(2)_B_cell-(23)_Follicular_B_cell\|Caecum / shred on region, Cell_type, and subtype	BEND5 PLEKHF2 ZNF318 CHMP7 LBH P2RY14	6.71e-05	200	153	6	68ac9006a88e87c6b1f779ddc1e1a42cc81dc35e
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	CLTCL1 RNF31 FAAP24 RBKS OCRL CLSTN1 CHMP7 KBTBD4 PDS5A DOP1A	7.21e-07	197	149	10	1148_DN
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; HL60; HG-U133A	TPMT TRIB2 KLF6 OCRL CASZ1 SLC7A9 AP5Z1 GDF11 KDM4B	5.97e-06	196	149	9	2031_UP
Drug	Oxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; HL60; HG-U133A	RNF31 KLF6 PLEKHF2 KBTBD4 CENPI MCF2L TOPORS KDM4B DOP1A	6.48e-06	198	149	9	1553_UP
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	MST1 RNF123 CELSR3	3.61e-06	7	140	3	EFO_0020797
Disease	coronary artery disease	NPC1 DAB2IP TET2 PDS5B FNDC3B CLTCL1 TTC41P NBEAL1 EFCAB13 AAK1 RNF213 PRDM8 MALRD1 ZNF335 NT5C2 PKHD1 PLCL1 MCF2L KDM4B	3.91e-06	1194	140	19	EFO_0001645
Disease	thioredoxin domain-containing protein 12 measurement	DOCK3 MST1 RNF123 CELSR3	3.51e-05	39	140	4	EFO_0008298
Disease	blood urea nitrogen measurement	TRIB2 MCM6 RBKS ZNF318 CASZ1 PRDM8 IGF2 SLC25A43 PCDHGB4 PKHD1	6.28e-05	452	140	10	EFO_0004741
Disease	mean arterial pressure	ZNF423 RNF213 ZNF318 XKR6 CASZ1 PRDM8 NT5C2 PKHD1 PDS5A KDM4B	1.41e-04	499	140	10	EFO_0006340
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L KLKB1	2.23e-04	25	140	3	DOID:0050589 (implicated_via_orthology)
Disease	urate measurement	DOCK3 POLE FAAP24 AAK1 MCM6 ZNF318 SLC7A9 PRDM8 IGF2 MALRD1 NT5C2 PKHD1 KDM4B	3.50e-04	895	140	13	EFO_0004531
Disease	systolic blood pressure, alcohol drinking	ZNF318 XKR6 CASZ1 PRDM8 EYS	3.71e-04	128	140	5	EFO_0004329, EFO_0006335
Disease	stomach cancer (is_implicated_in)	DAB2IP TET2 KLF6 KDM4B	3.89e-04	72	140	4	DOID:10534 (is_implicated_in)
Disease	cysteine-rich with EGF-like domain protein 1 measurement	RAD18 CAV3 MTMR14	4.69e-04	32	140	3	EFO_0021870
Disease	Colorectal Carcinoma	TET2 CPAMD8 POLE FPGS GPR87 CHST8 DNALI1 GMCL2 IGF2 PKHD1 P2RY14	5.41e-04	702	140	11	C0009402
Disease	unipolar depression, systolic blood pressure	CASZ1 PRDM8 NT5C2	5.62e-04	34	140	3	EFO_0003761, EFO_0006335
Disease	alpha-2-macroglobulin measurement	TET2 KLKB1	6.14e-04	8	140	2	EFO_0020138
Disease	hepatocyte growth factor-like protein measurement	DOCK3 MST1 CELSR3	7.81e-04	38	140	3	EFO_0008154
Disease	pulse pressure measurement	NPC1 TET2 FNDC3B NBEAL1 ZNF423 EFCAB13 RNF213 ZNF318 CASZ1 PRDM8 MALRD1 NT5C2 ACCSL MCF2L FHL2 KDM4B	9.57e-04	1392	140	16	EFO_0005763
Disease	Pulmonary Thromboembolisms	DAB2IP KLKB1	1.43e-03	12	140	2	C0524702
Disease	Pulmonary Embolism	DAB2IP KLKB1	1.43e-03	12	140	2	C0034065
Disease	inflammatory bowel disease (is_marker_for)	TPMT IGF2	1.43e-03	12	140	2	DOID:0050589 (is_marker_for)
Disease	cryptic phenotype measurement	XKR6 CASZ1 PRDM8	1.45e-03	47	140	3	EFO_0021487
Disease	systolic blood pressure, alcohol consumption measurement	XKR6 CASZ1 PRDM8	1.45e-03	47	140	3	EFO_0006335, EFO_0007878
Disease	cardiovascular disease	NPC1 EFCAB13 ZNF318 CASZ1 PRDM8 NT5C2 PKHD1 MCF2L	1.57e-03	457	140	8	EFO_0000319
Disease	osteitis deformans	NUP205 SLC25A43	1.68e-03	13	140	2	EFO_0004261
Disease	L2 Acute Lymphoblastic Leukemia	FPGS NBN NT5C2	1.74e-03	50	140	3	C0023453
Disease	Ciliopathies	ZNF423 PKHD1 TOPORS DNAH11	1.90e-03	110	140	4	C4277690
Disease	breast cancer (is_marker_for)	TET2 MYD88 NBN IGF2 KDM4B	1.93e-03	185	140	5	DOID:1612 (is_marker_for)
Disease	mean arterial pressure, alcohol consumption measurement	XKR6 CASZ1 PRDM8	1.95e-03	52	140	3	EFO_0006340, EFO_0007878
Disease	Childhood Acute Lymphoblastic Leukemia	FPGS NBN NT5C2	1.95e-03	52	140	3	C0023452
Disease	Down syndrome (implicated_via_orthology)	DOP1A DOP1B	2.25e-03	15	140	2	DOID:14250 (implicated_via_orthology)
Disease	Rhabdomyosarcoma	NBN IGF2	2.25e-03	15	140	2	C0035412
Disease	health study participation	NPC1 TET2 CELSR3 PLCL1 KDM4B	2.43e-03	195	140	5	EFO_0010130
Disease	cortical thickness	PDS5B CPAMD8 NBEAL1 ZNF423 ZNF318 XKR6 CHMP7 IGF2 MALRD1 NALF1 PCDHGB4 PKHD1 KDM4B	2.52e-03	1113	140	13	EFO_0004840
Disease	smoking behavior, BMI-adjusted waist circumference	DOCK3 FNDC3B ZBTB38 ZNF423	2.77e-03	122	140	4	EFO_0004318, EFO_0007789
Disease	Benign neoplasm of stomach	KLF6 POLE	2.90e-03	17	140	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	KLF6 POLE	2.90e-03	17	140	2	C0496905
Disease	low density lipoprotein cholesterol measurement, body fat percentage	EFCAB13 MCM6	2.90e-03	17	140	2	EFO_0004611, EFO_0007800
Disease	Carcinoma in situ of stomach	KLF6 POLE	2.90e-03	17	140	2	C0154060
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	TRIO KDM4B	2.90e-03	17	140	2	DOID:0060307 (is_implicated_in)
Disease	angina pectoris	NBEAL1 RNF213 PRDM8 NT5C2	3.02e-03	125	140	4	EFO_0003913
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	FPGS NBN NT5C2	3.08e-03	61	140	3	C1961102
Disease	Congenital Fiber Type Disproportion	ITGA7 MTMR14	3.25e-03	18	140	2	C0546264
Disease	age at onset, Parkinson disease	AAK1 KLHDC1	3.25e-03	18	140	2	EFO_0004847, MONDO_0005180
Disease	level of Phosphatidylcholine (15:0_18:2) in blood serum	RAD18 CAV3	3.25e-03	18	140	2	OBA_2045065
Disease	chronotype measurement	NPC1 DOCK3 RAD18 TRIM35 ZNF318 CAV3 RNF123 NALF1 NT5C2 PKHD1 PLCL1	3.30e-03	882	140	11	EFO_0008328
Disease	retinal vasculature measurement	PDS5B TRIO NBEAL1 AAK1 MCM6 FZD6 EYS PLCL1	3.35e-03	517	140	8	EFO_0010554
Disease	Tinnitus	ZNF318 XKR6 PKHD1 MINAR1	3.48e-03	130	140	4	HP_0000360
Disease	hypertension	ZNF423 RNF213 ZNF318 CASZ1 PRDM8 NT5C2	3.54e-03	307	140	6	EFO_0000537
Disease	Calcium channel blocker use measurement	RNF213 ZNF318 CASZ1 PRDM8 NT5C2	3.55e-03	213	140	5	EFO_0009930
Disease	Cannabis use, age at onset	ZNF423 PCDHGB4	3.63e-03	19	140	2	EFO_0004847, EFO_0007585
Disease	response to methotrexate, neurotoxicity	DAB2IP PLCL1	3.63e-03	19	140	2	EFO_0011057, GO_0031427
Disease	DNA methylation	FNDC3B TRIO ZNF423 RBKS RGMA PRDM10 IGF2 PKHD1 DNAH11	4.18e-03	656	140	9	GO_0006306
Disease	Stomach Carcinoma	KLF6 POLE	4.42e-03	21	140	2	C0699791
Disease	Nephritis, Tubulointerstitial	SLC7A9 SLC12A3	4.42e-03	21	140	2	C0041349
Disease	pulse pressure measurement, alcohol drinking	ZNF318 CASZ1 PRDM8	4.54e-03	70	140	3	EFO_0004329, EFO_0005763
Disease	lymphocyte percentage of leukocytes	TET2 ZBTB38 GRK5 NBN XKR6 GTF2IRD2B TADA2B GTF2IRD2 KDM4B	4.57e-03	665	140	9	EFO_0007993

Protein segments in the cluster

Peptide	Gene	Start	Entry
RFLEDNVCYALPVSC	BEND5	6	Q7L4P6
NVCYALPVSCVRDFS	BEND5	11	Q7L4P6
YLDPCTFEEERLLYC	ACCSL	491	Q4AC99
CCPLLNRFQLVFYLS	NAIP	491	Q13075
PELREACDYLCISFE	BTBD10	246	Q9BSF8
ETYLLACLVDFFTNC	NT5C2	161	P49902
ACLVDFFTNCPRYTS	NT5C2	166	P49902
CYFTLPFGESQVAIC	AAK1	256	Q2M2I8
VRDQFAYYSLQCLCP	CASZ1	1216	Q86V15
ASRPTCYLFLFNDVL	ARHGEF16	521	Q5VV41
YLRLPAQNCEETRFC	LINC00528	46	Q8N1L1
SNRSPYVLVCFQECE	DNAH11	4276	Q96DT5
CQLFLECSSFPVYIA	DOP1A	751	Q5JWR5
CRQDPSFLYRSLSCL	AP5Z1	336	O43299
DCSPQFSQICSYEII	CLSTN1	191	O94985
SVTSFFRYRQCLCVP	DIABLO	11	Q9NR28
IPFENCCTNETILRY	DHX32	146	Q7L7V1
FCLSPTNLLRRFCHY	CACNA1B	1131	Q00975
LLFDCLSVCYSESPV	NBEAL1	1551	Q6ZS30
ACCLADIFRIYAPEA	PDS5B	81	Q9NTI5
TCDYFPLLQLACSDT	OR6C1	176	Q96RD1
ACCLADIFRIYAPEA	PDS5A	91	Q29RF7
DLLRCGICFEYFNIA	RAD18	21	Q9NS91
CREYCQAIFRTDSSP	RECK	161	O95980
SRCEEYPLTRAFCQL	NUP205	696	Q92621
LLSLFCPALCEQIRY	PCDHGB4	21	Q9UN71
EPCFESYISFLCKQL	KRT76	231	Q01546
DPQFYTLSDVFCCNE	RBKS	186	Q9H477
ELAFCKIINSYCVFP	DAB2IP	476	Q5VWQ8
DLSYRLVFLACCVAP	MCM6	291	Q14566
ALDCVSAPRIQLFCY	OR11H2	201	Q8NH07
DRALNFDPCCISYFT	IFT122	276	Q9HBG6
SRFQETFCALDPCVL	MATN3	256	O15232
ISDNENLFCECPRLY	EYS	2351	Q5T1H1
CYTTDPQIEREFCDL	MST1L	221	Q2TV78
CLELFGRDYCFSVIP	MTMR14	61	Q8NCE2
PDLRDTCDYLCINFD	KCTD20	196	Q7Z5Y7
CFEECFRPVKQRYSV	DOP1B	451	Q9Y3R5
SYQIFPDPSDFDRCC	LBH	41	Q53QV2
EFLLPCLCIEASYLQ	IL17RE	236	Q8NFR9
PYSFTINFCQEECLR	NUDT6	231	P53370
AAARTEPYCAICTLF	KDM4B	676	O94953
FDAFICYCPSDIQFV	MYD88	161	Q99836
SILRFITVCDYTNPC	MYD88	266	Q99836
RTYFPFSCSCLNQLL	GDPD3	236	Q7L5L3
YVLPEVICRSCNFCR	POLE	2151	Q07864
FYFLCLAETTDCFLL	OR5K3	101	A6NET4
PCYECNRRFISSEQL	PRDM10	356	Q9NQV6
KTYSCIFCPESFDRL	PRDM10	586	Q9NQV6
DYFFCDIPAVLRLAC	OR10G3	176	Q8NGC4
LLSLFCPALCEQIRY	PCDHGB5	21	Q9Y5G0
FLSACNVCLDPIIYF	GPR87	301	Q9BY21
FSLPCLRLFLVVTCY	LRRC70	6	Q7Z2Q7
PVFLTACIDYCLNFS	GPR160	111	Q9UJ42
LQFLSRCPSCFYNLL	NPC1	91	O15118
FYNLLNLFCELTCSP	NPC1	101	O15118
SPCEADQFSCIYTLQ	MALRD1	1901	Q5VYJ5
ASRYFVLLPLCLCVF	FZD6	366	O60353
CILYLLCFRQHPFED	GAK	251	O14976
NNYRESLPCTICLEF	G2E3	136	Q7L622
IPLCRELACQYESLY	DOCK3	1311	Q8IZD9
PCAYEIRQFLDCSTT	CHCHD10	101	Q8WYQ3
LCANSCPDERTFYLV	CHMP7	186	Q8WUX9
CYFCLPILFTVTCQL	GPR37L1	316	O60883
RFEIRDLLPAAQYCC	FNDC3B	821	Q53EP0
LTPDFYLSNRCCILY	FAAP24	46	Q9BTP7
AIICLSFSEYVCAPF	SLC7A9	126	P82251
LFYFDEIPSRCLTCV	CPAMD8	1611	Q8IZJ3
SRCCRYPLTVDFEAF	GDF11	311	O95390
LAFASCCIAAYRPSE	IGF2	16	P01344
YCPQCDALFDELTAR	ABCA2	2131	Q9BZC7
YSLCIRTFCNPLFAA	CAV3	121	P56539
LREESPYCVVCFETL	FHL2	21	Q14192
FYLICTYCPDLERQA	EFCAB13	906	Q8IY85
CPVRRELYSQCFDEL	DNALI1	121	O14645
ENYTDCPELVGRCFL	MCF2L	701	O15068
CLDDFYRKFAPVCSI	FBLIM1	291	Q8WUP2
CQFDYAVFCPNLTEV	FPGS	431	Q05932
IRCQFFTYSLLPEDC	KLKB1	326	P03952
FQTQPYSLLRSCLDC	KLHDC1	336	Q8N7A1
LSYCQFTRDCFSEKP	KRCC1	101	Q9NPI7
LFACPLSLEETDCYR	ITGA7	91	Q13683
CVDLRVCFSYIAVPS	ITGA7	546	Q13683
CVVFSCPLYSFDRAA	ITGA7	1001	Q13683
CYTTDPQIEREFCDL	MST1	251	P26927
IIRAECFLQEGFYSC	CENPI	421	Q92674
FCETELDLCYSNPCR	CELSR3	1431	Q9NYQ7
CETRPGLECYIQFLD	GRK5	71	P34947
YFFVEVQNIPTCLIC	GTF2IRD2	436	Q86UP8
YFFVEVQNIPTCLIC	GTF2IRD2B	436	Q6EKJ0
ETCPYCFQLLVLDNS	C18orf21	41	Q32NC0
YCCFERVCLFKPITS	CMTR1	421	Q8N1G2
PALERLQRCTFCYDV	COL6A6	1931	A6NMZ7
IDPYLYIASCVNDLC	OTOGL	336	Q3ZCN5
QSSKPVRICDFCYDL	PLEKHF2	196	Q9H8W4
NFAATLECPIIFFCR	BCKDHA	251	P12694
ALDCVSAPRIQLFCY	OR11H1	201	Q8NG94
ALDCVSAPRIQLFCY	OR11H12	201	B2RN74
ASCPIFVITIENYCN	OR2B2	336	Q9GZK3
CNLTVADLFYICSLP	GPR68	61	Q15743
SFNCVADPVLYCFVS	GPR68	276	Q15743
LRSVLFYTACLDPNF	MINAR1	46	Q9UPX6
FCNIYPLLDLECTDT	OR4A8	176	P0C604
PFFCELSIKDYTCLL	NR6A1	306	Q15406
LLYCFPVCLQFFTLT	GPR137B	116	O60478
ACCAFYSRNISPIEV	RTL1	901	A6NKG5
PSRSFKEELLCAVCY	TRIM35	11	Q9UPQ4
CAVCYDPFRDAVTLR	TRIM35	21	Q9UPQ4
YCLAEVSPLRFRCTE	TADA2B	11	Q86TJ2
FRIEYEPLVACSSCL	NBN	106	O60934
CLELTDSCQPYRSAF	NBPF8	611	Q3BBV2
CLELTDSCQPYRSAF	NBPF9	646	P0DPF3
CLELTDSCQPYRSAF	NBPF10	646	Q6P3W6
CLELTDSCQPYRSAF	NBPF10	1866	Q6P3W6
CLELTDSCQPYRSAF	NBPF10	3086	Q6P3W6
CLELTDSCQPYRSAF	NBPF14	306	Q5TI25
CLELTDSCQPYRSAF	NBPF19	1351	A0A087WUL8
CLELTDSCQPYRSAF	NBPF19	2571	A0A087WUL8
CLELTDSCQPYRSAF	NBPF20	31	P0DPF2
CLELTDSCQPYRSAF	NBPF20	1251	P0DPF2
CLELTDSCQPYRSAF	NBPF20	2471	P0DPF2
CLELTDSCQPYRSAF	NBPF20	3691	P0DPF2
CLELTDSCQPYRSAF	NBPF20	4911	P0DPF2
CLELTDSCQPYRSAF	NBPF26	306	B4DH59
CLELTDSCQPYRSAF	NBPF26	381	B4DH59
CLELTDSCQPYRSAF	NBPF26	456	B4DH59
CLELTDSCQPYRSAF	NBPF26	531	B4DH59
CLELTDSCQPYRSAF	NBPF26	606	B4DH59
LLSTNCVLDPVIYCF	PTAFR	281	P25105
CRSCRTYINPFVSFL	SEC24A	431	O95486
LVCYNPLLDSFTRLC	KBTBD4	441	Q9NVX7
TCLECSQRFQFEFPY	PRDM8	156	Q9NQV8
LDSRFLTFPLYICCN	GMCL2	491	Q8NEA9
YLYICEESSQCLFVP	PKHD1	1836	P08F94
CLRLFPCSAVQLAAY	SLC25A43	76	Q8WUT9
FYFLCLAETTDCFLL	OR5K4	101	A6NMS3
HFFCDILPLYRLSCT	OR5K4	176	A6NMS3
ANVCLDPIIYFFLCQ	P2RY14	286	Q15391
DTPEFCAALRSYALC	RGMA	71	Q96B86
PVICYELYQRCLDSA	OCRL	801	Q01968
FAACLFTCYDLLRPD	CLTCL1	1566	P53675
VSRLCSPCLIDYDFV	CHST8	331	Q9H2A9
FIYEREQLEATCPQC	RNF31	806	Q96EP0
FLNYQLRDCEASLFC	RNF213	2221	Q63HN8
AFCELCTRPEVYFLL	PLCL1	306	Q15111
SYAVPALCCVFISFV	XKR6	471	Q5GH73
QESIFLCEDLQCIYP	USPL1	66	Q5W0Q7
CIFPRCIFSAIDAVY	THOC2	981	Q8NI27
RSLCYPDTDVFLACF	RHOV	96	Q96L33
CPFCQRELYEDSLLD	RNF125	141	Q96EQ8
LADPCFQLRSICYLL	RNF123	1176	Q5XPI4
AYELLAPCFQKALSC	TONSL	406	Q96HA7
VFDISCYQESLAPCF	TRIB2	91	Q92519
RLKLCLDYVNSCFPF	TTC41P	91	Q6P2S7
QCLCEDQLYPLIGFF	SLC12A3	481	P55017
CPDISFFQRATDYPC	TBC1D13	131	Q9NVG8
LNCVADPILYCFVTE	GPR65	281	Q8IYL9
YQRLISPDCCYDAFI	TLR7	881	Q9NYK1
ICRDRSVFTALFYCP	ZDHHC23	326	Q8IYP9
QTALFCSACREYPSI	ZNF862	156	O60290
SKCPICLDRFDNVSY	TOPORS	101	Q9NS56
CSEVYLDCLQTFLPA	XPOT	676	O43592
ISFLQELSCFVTRCY	WASHC4	141	Q2M389
CPYCSKRDFNSLAVL	ZNF423	411	Q2M1K9
TGERRYQCIFCLETF	ZBTB38	511	Q8NAP3
LTCFPFTSRFCEKYE	RHBDF2	836	Q6PJF5
TQYDFPSCRCVEQII	TET2	1126	Q6N021
GNISLYCCSIFDLPR	TPMT	126	P51580
CSFCPYRTFREDFLL	ZNF335	651	Q9H4Z2
VPISGFYCQLCEEFL	ZNF318	1131	Q5VUA4
FYCQLCEEFLGDPIS	ZNF318	1136	Q5VUA4
LFLCLNDYETVSCPS	TBCEL	156	Q5QJ74
CLNICRLDFSFPDDY	TRIO	3001	O75962
CLELERYLQSEPCYV	KLF6	36	Q99612
YFEVTQFNCRKTIPC	NALF1	316	B1AL88