Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	UDP-glucose:glycoprotein glucosyltransferase activity	UGGT1 UGGT2	2.38e-05	2	98	2	GO:0003980
GeneOntologyBiologicalProcess	UDP-glucosylation	UGGT1 UGGT2	2.19e-05	2	97	2	GO:0097359
GeneOntologyBiologicalProcess	SREBP-SCAP complex retention in endoplasmic reticulum	INSIG1 INSIG2	2.19e-05	2	97	2	GO:0036316
GeneOntologyBiologicalProcess	negative regulation of SREBP signaling pathway	INSIG1 INSIG2	6.55e-05	3	97	2	GO:2000639
GeneOntologyCellularComponent	SREBP-SCAP-Insig complex	INSIG1 INSIG2	7.05e-05	3	102	2	GO:0032937
GeneOntologyCellularComponent	stereocilium membrane	MYO1C ADGRV1	3.49e-04	6	102	2	GO:0060171
GeneOntologyCellularComponent	periciliary membrane compartment	ADGRV1 KIF17	3.49e-04	6	102	2	GO:1990075
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	IPR032754
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	IPR029423
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	IPR015753
Domain	INSIG_fam	INSIG1 INSIG2	2.95e-05	2	102	2	IPR025929
Domain	UDP-g_GGtrans	UGGT1 UGGT2	2.95e-05	2	102	2	IPR009448
Domain	INSIG	INSIG1 INSIG2	2.95e-05	2	102	2	PF07281
Domain	INSIG-1	INSIG1 INSIG2	2.95e-05	2	102	2	IPR009904
Domain	UDP-g_GGTase	UGGT1 UGGT2	2.95e-05	2	102	2	PF06427
Domain	ARM-type_fold	NBEAL1 INTS1 MROH5 COPG2 MEI1 VIRMA RYR3 NCAPG NCAPD2	1.00e-04	339	102	9	IPR016024
Domain	LRR	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 RABGGTA LRRC15	1.17e-04	201	102	7	PS51450
Domain	LRR_1	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 RABGGTA LRRC15	1.99e-04	219	102	7	PF00560
Domain	LRR_8	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 LRRC15	3.52e-04	171	102	6	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 LRRC15	4.22e-04	177	102	6	IPR003591
Domain	LRR_TYP	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 LRRC15	4.22e-04	177	102	6	SM00369
Domain	Leu-rich_rpt	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 RABGGTA LRRC15	7.16e-04	271	102	7	IPR001611
Domain	-	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 RABGGTA LRRC15	1.90e-03	321	102	7	3.80.10.10
Domain	L_dom-like	LRRC37A3 LRRC37A2 PIDD1 LRRC37A TLR5 RABGGTA LRRC15	2.15e-03	328	102	7	IPR032675
Domain	Clathrin/coatomer_adapt-like_N	COPG2 NCAPD2	2.96e-03	15	102	2	IPR002553
Domain	Adaptin_N	COPG2 NCAPD2	2.96e-03	15	102	2	PF01602
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	9.78e-08	4	102	3	22419166
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPR HK1 MYO1C RPN2 UGGT1 INTS1 COPG2 VIRMA MDN1 SYNE2 NCAPD2 HERC2	5.04e-07	653	102	12	22586326
Pubmed	Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.	ADGRV1 THYN1 USP40 HERC2	1.16e-06	27	102	4	34709416
Pubmed	Defining the membrane proteome of NK cells.	MYO1C GHDC RPN2 GOSR1 INTS1 ITGB1 PHB1 ESYT2 NCAPG MDN1 CLCN7 NCAPD2 CHST12 HERC2 BAG6	1.62e-06	1168	102	15	19946888
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	TPR RPN2 COPG2 TMEM214 ITGB1 ESYT2 MDN1 CLCN7 SYNE2	1.70e-06	375	102	9	32788342
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CCDC14 MYO1C RPN2 UGGT1 COPG2 PPFIA3 ITGB1 ESYT2 KMT2D NCAPG CLCN7 PTPRN SYNE2 HERC2	2.39e-06	1049	102	14	27880917
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	MYO1C GHDC RPN2 UGGT1 TMEM214 ITGB1 ESYT2 CLCN7 BAG6	2.44e-06	392	102	9	33144569
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A	2.90e-06	10	102	3	23064749
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	TPR MYO1C UGGT1 COPG2 ITGB1 PHB1 ESYT2 NCAPG MDN1 XPNPEP3 NCAPD2	3.27e-06	647	102	11	26618866
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	HK1 MYO1C RPN2 UGGT1 GOSR1 LAMB1 COPG2 ITGB1 PHB1 ESYT2 NCAPG MDN1 SYNE2 NCAPD2 MRPS9 BAG6	4.53e-06	1440	102	16	30833792
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	HK1 MYO1C UGGT1 COPG2 TMEM214 ESYT2 NCAPG GTF2H4 NCAPD2 BAG6	6.12e-06	560	102	10	35241646
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	HK1 RPN2 UGGT1 LAMB1 TMEM214 ITGB1 PHB1 ESYT2 NCAPG MDN1 CLCN7 SYNE2 MRPS9 UGGT2 HERC2 BAG6	6.78e-06	1487	102	16	33957083
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	TPR NBEAL1 GOSR1 COPG2 TMEM214 ITGB1 ESYT2 CLCN7 SYNE2 PRR14L	6.92e-06	568	102	10	37774976
Pubmed	Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.	UGGT1 UGGT2	8.52e-06	2	102	2	10694380
Pubmed	Biochemical characterization of TRIM72 E3 ligase and its interaction with the insulin receptor substrate 1.	TRIM72 IRS1	8.52e-06	2	102	2	32055715
Pubmed	Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7.	NCAPG NCAPD2	8.52e-06	2	102	2	12138188
Pubmed	An MG53-IRS1-interaction disruptor ameliorates insulin resistance.	TRIM72 IRS1	8.52e-06	2	102	2	29884820
Pubmed	UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.	UBQLN4 BAG6	8.52e-06	2	102	2	27113755
Pubmed	Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.	INSIG1 INSIG2	8.52e-06	2	102	2	20877301
Pubmed	Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2.	UGGT1 UGGT2	8.52e-06	2	102	2	33320095
Pubmed	Effects of domain composition on catalytic activity of human UDP-glucose:glycoprotein glucosyltransferases.	UGGT1 UGGT2	8.52e-06	2	102	2	27496766
Pubmed	Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.	INSIG1 INSIG2	8.52e-06	2	102	2	24337570
Pubmed	Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.	INSIG1 INSIG2	8.52e-06	2	102	2	20090767
Pubmed	Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.	INSIG1 INSIG2	8.52e-06	2	102	2	19638338
Pubmed	Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.	INSIG1 INSIG2	8.52e-06	2	102	2	16955138
Pubmed	IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.	XBP1 IRS1	8.52e-06	2	102	2	27378176
Pubmed	Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.	INSIG1 INSIG2	8.52e-06	2	102	2	19360322
Pubmed	The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.	INSIG1 INSIG2	8.52e-06	2	102	2	18989534
Pubmed	Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.	INSIG1 INSIG2	8.52e-06	2	102	2	19617589
Pubmed	Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.	INSIG1 INSIG2	8.52e-06	2	102	2	12624180
Pubmed	Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT).	UGGT1 UGGT2	8.52e-06	2	102	2	24140206
Pubmed	Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.	PHB1 MTHFR	8.52e-06	2	102	2	22669161
Pubmed	The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.	UGGT1 UGGT2	8.52e-06	2	102	2	12913004
Pubmed	Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.	DUOX2 TLR5	8.52e-06	2	102	2	21714724
Pubmed	Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active.	UGGT1 UGGT2	8.52e-06	2	102	2	24415556
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	UGGT1 GOSR1 PEX1 TMEM214 ITGB1 ESYT2 CLCN7 SYNE2 UGGT2	1.02e-05	468	102	9	31056421
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	INTS1 PIDD1 EVPL IRS1 PPFIA3 RPS6KC1 MYO15B MDN1 THYN1 CEP295 ARHGAP20	1.10e-05	736	102	11	29676528
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZFP90 GHDC RPN2 INTS1 IRS1 TMEM214 ITGB1 VIRMA WAC PHB1 ESYT2 GTF2H4 NCAPD2 BAG6	1.14e-05	1203	102	14	29180619
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	UGGT1 PEX1 COPG2 TMEM214 ITGB1 MDN1 XPNPEP3 MRPS9 UGGT2 HERC2 BAG6	1.38e-05	754	102	11	33060197
Pubmed	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	ZFP90 LAMB1 INAVA	1.62e-05	17	102	3	19915572
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	GOSR1 PEX1 TMEM214 ITGB1 RPS6KC1 ESYT2 CLCN7 SYNE2 BAG6	1.82e-05	504	102	9	34432599
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	GHDC RPN2 UBQLN4 PEX1 COPG2 TMEM214 PHB1 ESYT2 NCAPG NCAPD2 UGGT2 BAG6	2.10e-05	942	102	12	31073040
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	TPR MYO1C RPN2 UGGT1 GOSR1 INTS1 LAMB1 IRS1 TMEM214 ITGB1 PHB1 ESYT2 XPNPEP3 UGGT2 BAG6	2.16e-05	1451	102	15	30550785
Pubmed	Immunohistochemical localization of extracellular matrix proteins in developing lung tissues.	LAMB1 ITGB1	2.55e-05	3	102	2	17334455
Pubmed	Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.	INSIG1 INSIG2	2.55e-05	3	102	2	24806461
Pubmed	TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration.	LAMB1 ITGB1	2.55e-05	3	102	2	34427057
Pubmed	Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.	INSIG1 INSIG2	2.55e-05	3	102	2	16549805
Pubmed	Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands.	INSIG1 INSIG2	2.55e-05	3	102	2	31558435
Pubmed	Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.	INSIG1 INSIG2	2.55e-05	3	102	2	31953408
Pubmed	Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis.	LAMB1 ITGB1	2.55e-05	3	102	2	8951069
Pubmed	A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.	IRS1 ITGB1	2.55e-05	3	102	2	9844629
Pubmed	Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.	INSIG1 INSIG2	2.55e-05	3	102	2	34298014
Pubmed	Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.	INSIG1 INSIG2	2.55e-05	3	102	2	12482938
Pubmed	Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.	UGGT1 UGGT2	2.55e-05	3	102	2	11278576
Pubmed	Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.	INSIG1 INSIG2	5.09e-05	4	102	2	19740467
Pubmed	MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.	TRIM72 IRS1	5.09e-05	4	102	2	23965929
Pubmed	Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.	INSIG1 INSIG2	5.09e-05	4	102	2	15899885
Pubmed	The use of whole exome sequencing for the diagnosis of autosomal recessive malignant infantile osteopetrosis.	CLCN7 SNX10	5.09e-05	4	102	2	27187610
Pubmed	Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.	INSIG1 INSIG2	5.09e-05	4	102	2	12842885
Pubmed	Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.	INSIG1 INSIG2	5.09e-05	4	102	2	16606821
Pubmed	Developmental regulation of genes mediating murine brain glucose uptake.	HK1 SLC2A14	5.09e-05	4	102	2	10070152
Pubmed	Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells.	LAMB1 ITGB1	5.09e-05	4	102	2	24706882
Pubmed	Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production.	HK1 XBP1	5.09e-05	4	102	2	20208012
Pubmed	Reduced immunohistochemical expression of adhesion molecules in vitiligo skin biopsies.	LAMB1 ITGB1	5.09e-05	4	102	2	28214208
Pubmed	Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.	TRIM72 IRS1	5.09e-05	4	102	2	23354051
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	TPR RPN2 GOSR1 COPG2 ITGB1 PHB1 CLCN7 NCAPD2	5.51e-05	449	102	8	31732153
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	PEX1 COPG2 KMT2D PRR14L HERC2	5.79e-05	139	102	5	25476789
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	INTS1 IQCD HELB KMT2D NCAPG NCAPD2 BAG6 LRRC15	7.47e-05	469	102	8	27634302
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	HK1 MYO1C RPN2 UGGT1 DUOX2 GPR101 PHB1 RPS6KC1 MDN1 SYNE2 NCAPD2 MRPS9 UGGT2 CEP295	8.18e-05	1442	102	14	35575683
Pubmed	Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.	XBP1 DUOX2	8.47e-05	5	102	2	36917985
Pubmed	Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.	INSIG1 INSIG2	8.47e-05	5	102	2	12242332
Pubmed	MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle.	TRIM72 IRS1	8.47e-05	5	102	2	27810898
Pubmed	The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.	INSIG1 INSIG2	8.47e-05	5	102	2	25028659
Pubmed	Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.	INSIG1 INSIG2	8.47e-05	5	102	2	29374057
Pubmed	Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.	IRS1 ITGB1	8.47e-05	5	102	2	36125265
Pubmed	Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.	INSIG1 INSIG2	8.47e-05	5	102	2	22143767
Pubmed	Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?	INSIG1 INSIG2	8.47e-05	5	102	2	18195716
Pubmed	Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.	LAMB1 ITGB1	8.47e-05	5	102	2	7544312
Pubmed	Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.	INSIG1 INSIG2	8.47e-05	5	102	2	16100574
Pubmed	Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene.	INSIG1 INSIG2	8.47e-05	5	102	2	30733434
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	INTS1 MAP10 VIRMA ARHGAP20 KIF17	9.12e-05	153	102	5	10718198
Pubmed	Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.	INSIG1 INSIG2 BAG6	1.14e-04	32	102	3	19815544
Pubmed	Chromosome condensation by a human condensin complex in Xenopus egg extracts.	NCAPG NCAPD2	1.27e-04	6	102	2	11136719
Pubmed	Preeclampsia and its interaction with common variants in thrombophilia genes.	CPB2 MTHFR	1.27e-04	6	102	2	15333035
Pubmed	Integrins as receptors for laminins.	LAMB1 ITGB1	1.27e-04	6	102	2	11054877
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	XBP1 RYR3	1.27e-04	6	102	2	19009018
Pubmed	Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers?	PHB1 MTHFR	1.27e-04	6	102	2	19071013
Pubmed	Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.	LAMB1 ITGB1	1.27e-04	6	102	2	19118221
Pubmed	Prothrombotic polymorphisms, mutations, and their association with pediatric non-cardioembolic stroke in Asian-Indian patients.	CPB2 MTHFR	1.77e-04	7	102	2	18836720
Pubmed	The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.	ESYT2 BAG6	1.77e-04	7	102	2	28075048
Pubmed	Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development.	LAMB1 ITGB1	1.77e-04	7	102	2	8722691
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	TPR MYO1C RPN2 COPG2 ESYT2 MDN1 NCAPD2	1.80e-04	399	102	7	37536630
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CCDC14 NBEAL1 SAMD4B INTS1 XBP1 PHC1 ESYT2 MDN1 ASXL2	1.99e-04	689	102	9	36543142
Pubmed	RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.	IRS1 ITGB1	2.36e-04	8	102	2	15611085
Pubmed	Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions.	NCAPG NCAPD2	2.36e-04	8	102	2	25474630
Pubmed	Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.	INSIG1 INSIG2	2.36e-04	8	102	2	24371122
Pubmed	Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.	NCAPG NCAPD2	2.36e-04	8	102	2	14532007
Pubmed	ABO blood group but not haemostasis genetic polymorphisms significantly influence thrombotic risk: a study of 180 homozygotes for the Factor V Leiden mutation.	CPB2 MTHFR	2.36e-04	8	102	2	17107352
Pubmed	Reconstitution and subunit geometry of human condensin complexes.	NCAPG NCAPD2	2.36e-04	8	102	2	17268547
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 COPG2 ESYT2 MDN1	2.56e-04	104	102	4	31240132
Interaction	SEC61B interactions	HK1 RPN2 INSIG1 UGGT1 LAMB1 COPG2 TMEM214 ITGB1 PHB1 ESYT2 CLCN7 SYNE2 UGGT2 ARHGAP20 BAG6	5.90e-06	763	101	15	int:SEC61B
Interaction	ZNF772 interactions	INSIG1 VIRMA INSIG2	1.00e-05	9	101	3	int:ZNF772
Interaction	SYNE3 interactions	CCDC14 RPN2 UGGT1 SAMD4B PEX1 LAMB1 ITGB1 ESYT2 SYNE2 UGGT2 CEP295	1.40e-05	444	101	11	int:SYNE3
Interaction	AXL interactions	RPN2 UGGT1 COPG2 ITGB1 VIRMA TYRO3 ESYT2 MDN1 MRPS9 BAG6	1.64e-05	369	101	10	int:AXL
Interaction	SSR1 interactions	HK1 RPN2 COPG2 TMEM214 ITGB1 VIRMA PHB1 TYRO3 ESYT2 CLCN7 SYNE2	1.69e-05	453	101	11	int:SSR1
Interaction	UGGT1 interactions	UGGT1 VIRMA RYR3 PHB1 PTPRN CHST12 UGGT2 RABGGTA	2.41e-05	235	101	8	int:UGGT1
Interaction	ATL3 interactions	TPR HK1 COPG2 ITGB1 VIRMA PHB1 ESYT2	3.30e-05	179	101	7	int:ATL3
Interaction	VAPA interactions	ASB17 RPN2 INSIG1 UGGT1 GOSR1 LAMB1 ITGB1 VIRMA PHB1 ESYT2 SYNE2 USP40 UGGT2	3.82e-05	686	101	13	int:VAPA
Interaction	UNC93B1 interactions	HK1 RPN2 UGGT1 GOSR1 COPG2 GPR101 PHB1 ESYT2 MDN1 NCAPD2	4.64e-05	417	101	10	int:UNC93B1
Interaction	PTPN1 interactions	HK1 RPN2 GOSR1 PEX1 IRS1 TMEM214 ITGB1 PHB1 ESYT2 SYNE2 CEP295 HERC2	6.85e-05	625	101	12	int:PTPN1
Cytoband	4p15.33	RAB28 NCAPG	3.83e-04	13	103	2	4p15.33
Cytoband	2q36.1	MOGAT1 SGPP2	8.31e-04	19	103	2	2q36.1
Cytoband	2q14.2	INSIG2 MARCO	9.22e-04	20	103	2	2q14.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q36	MOGAT1 SGPP2 IRS1	9.48e-04	85	103	3	chr2q36
GeneFamily	UDP-glucose glycoprotein glucosyltransferases	UGGT1 UGGT2	1.31e-05	2	66	2	440
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb-Excitatory_Neuron.Sc17a7.Rorb-Gpr83_(Layer_5a)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM72 OTOA DUOX2 MEI1 MSLNL	5.27e-06	108	103	5	5af010a1ee6535b144ccd16999c225508a4b3433
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|megakaryocytic / Lineage and Cell class	CCDC14 TPR NBEAL1 RPN2 XBP1 PHB1	6.95e-06	199	103	6	99a65887d3c8a2cde26693dd74404b101bba9d58
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM72 OTOA DUOX2 MEI1 MSLNL	7.47e-06	116	103	5	9c92e714e210a2f29a9e228653d4c990ec643c72
Disease	cutaneous melanoma, hair color	ADGRV1 SYNE2 HERC2 ARHGAP20	5.96e-05	62	100	4	EFO_0000389, EFO_0003924
Disease	Infantile malignant osteopetrosis	CLCN7 SNX10	6.79e-05	4	100	2	C1318518
Disease	glucose metabolism disease (implicated_via_orthology)	HK1 IRS1 TLR5	1.16e-04	28	100	3	DOID:4194 (implicated_via_orthology)
Disease	chronic kidney disease (is_implicated_in)	CPB2 MTHFR	1.01e-03	14	100	2	DOID:784 (is_implicated_in)
Disease	anemia (is_implicated_in)	HK1 MTHFR	1.01e-03	14	100	2	DOID:2355 (is_implicated_in)
Disease	white matter integrity	NBEAL1 CCDC88C BAG6 SLC4A9	1.02e-03	130	100	4	EFO_0004641
Disease	Lymphoma, Large-Cell, Follicular	KMT2D MTHFR	1.16e-03	15	100	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	KMT2D MTHFR	1.16e-03	15	100	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	KMT2D MTHFR	1.16e-03	15	100	2	C0079758
Disease	Lymphoma, Follicular, Grade 2	KMT2D MTHFR	1.16e-03	15	100	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	KMT2D MTHFR	1.16e-03	15	100	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	KMT2D MTHFR	1.16e-03	15	100	2	C1956130
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	OTOA CPB2	1.87e-03	19	100	2	EFO_0008582
Disease	Lymphoma, Follicular	KMT2D MTHFR	2.08e-03	20	100	2	C0024301
Disease	Infiltrating duct carcinoma of female breast	RPS6KC1 NRK	2.29e-03	21	100	2	C3165106
Disease	small cell lung carcinoma	ADGRV1 PHC1 BAG6	2.57e-03	80	100	3	EFO_0000702
Disease	Coronary heart disease	IRS1 MTHFR	2.99e-03	24	100	2	C0010068

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLPIATQELRQRLRQ	ESYT2	761	A0FGR8
QQLRPTQNLQPRIKL	DAPK1	676	P53355
ELRGQLQALLLQRPQ	SLC4A9	166	Q96Q91
QELQRLESRLQPFLQ	BAG6	281	P46379
LRLLLSNPQAARLLQ	IQCD	156	Q96DY2
RPLQFRIQQLEALQR	ALDH3A1	21	P30838
QVANLLRLFQIPQIS	GRM3	156	Q14832
GQNLIRSIQINITRL	ADGRV1	4776	Q8WXG9
NAQLRRQLRILNQQL	CCDC14	491	Q49A88
ILQTLIQRVRRQNLL	ASXL2	1066	Q76L83
ISLLPDNILQVLRIQ	NBEAL1	56	Q6ZS30
QNVNITLRILFRPVA	PHB1	86	P35232
LRRITLPGNLNVTLQ	RAB28	51	P51157
IPIKNALNLRNRQVI	PACRG	151	Q96M98
QRQIALRNQRETLPL	TSPOAP1	276	O95153
ITQIQPQQLVLRLRS	ITGB1	111	P05556
AQRRRLSPLQLQSLQ	OTOA	1086	Q7RTW8
APLNIQLARRLQTVA	MOGAT1	6	Q96PD6
LLRVNRQGILTINSQ	MTHFR	471	P42898
TSPVLQRLQGVLRQL	PTPRN	76	Q16849
LQSVIPNNNVRRLIA	LRRC37A3	1481	O60309
QNLNRALRETLLAQP	MDN1	4016	Q9NU22
RFPAVNSLIQRINLR	GOSR1	211	O95249
QNRINTIRQLPLLNA	MAP10	386	Q9P2G4
LQSLIPNNNVRRLIA	LRRC37A2	1481	A6NM11
LQSLIPNNNVRRLIA	LRRC37A	1481	A6NMS7
QPIDNVSRNLLRLLT	INTS1	341	Q8N201
SLIQQLLQFNPLERL	RPS6KC1	1026	Q96S38
LPLVQLIQQLLRNIA	HERC2	1006	O95714
LLQIPTQNAQARQLL	PPFIA3	1086	O75145
RLTIRNQLLTNNMLP	ASB17	261	Q8WXJ9
VNLRIQNLTILVRNI	CCDC88C	71	Q9P219
VLRVVQLQPLQQVNL	DUOX2	681	Q9NRD8
QPARLQGLILRSQLI	CLCN7	671	P51798
RQSTLQLLRKVLQIP	HMGXB3	686	Q12766
LQPNQEALLQALQRL	IDO2	206	Q6ZQW0
EAQRSQLLQLRTQRP	EVPL	936	Q92817
LLLPTLALLRQQRSQ	GHDC	11	Q8N2G8
VVLALVLNLLQIQRN	INSIG1	96	O15503
VLNLLQIQRNVTLFP	INSIG1	101	O15503
VRIPVALQRQLEQRQ	DDX28	36	Q9NUL7
SPRIQNLLKITNLRI	LAMB1	221	P07942
SALIQRLALLQVPLQ	MSLNL	76	Q96KJ4
LQRKPQLLQVTNRFI	GPR101	56	Q96P66
LNLLQIQRNVTLFPP	INSIG2	46	Q9Y5U4
LPRAREQQQQQQPLL	IRS1	871	P35568
ALLQVRAILQQLGLN	HK1	796	P19367
RQPIIISIVLQLSQQ	SLC2A14	291	Q8TDB8
LRRTPLLNDLQPLQN	OOSP4A	36	A0A2R8YFL7
QVRSLVIGLQNLLVQ	MEI1	1101	Q5TIA1
NTILLVAQPLLQRRQ	MYO15B	386	Q96JP2
VAQPLLQRRQRLQLG	MYO15B	391	Q96JP2
ALPRTSRQVQVLQNL	CPB2	31	Q96IY4
VSPLLLVTILRNQRL	GPR148	66	Q8TDV2
QNESLLPSILVLLQR	COPG2	501	Q9UBF2
GLLVVQVLNLQARLR	MARCO	61	Q9UEW3
NRLNPFPILIQNILN	ETFBKMT	161	Q8IXQ9
PQLQDRLLRISQLIQ	CEP295	1331	Q9C0D2
RLLRISQLIQPQQDN	CEP295	1336	Q9C0D2
PLSSLERQLALQLQI	INAVA	186	Q3KP66
LPRRLVAQLHLLQNQ	PEX1	31	O43933
VSSRLQNLRLNNLIP	HELB	1061	Q8NG08
LEFPQLIRVSQLQIQ	NR2C2AP	51	Q86WQ0
QQPLQLLQVEFLRLS	PIDD1	56	Q9HB75
LLSQNRALPLELQRT	PRR14L	56	Q5THK1
RPSNRVLLQALQILV	PTCD2	11	Q8WV60
LLQQLLEQVQPLIRR	KIF17	856	Q9P2E2
RQIPAVLRQLLPSLQ	MROH5	996	Q6ZUA9
LQAQVRAPRLLQVQS	NRK	481	Q7Z2Y5
RQIQVLEPLNLLITI	NRK	1251	Q7Z2Y5
QRLLDQLPRANVVLL	ARHGAP20	471	Q9P2F6
IRQIQLAKRLNLPVN	TATDN3	131	Q17R31
LLLTLLLQRIRSIQN	SYNE2	3526	Q8WXH0
LRQLQVLILSRNQIS	LRRC15	316	Q8TF66
PGTIRIQNSQLQLQL	PKNOX1	231	P55347
NLPRLQELLLCNNRL	RABGGTA	506	Q92696
ALRLRAPLQQVQAQL	XBP1	166	P17861
NLLRQLLPALQATLQ	WAC	361	Q9BTA9
ENVIIILLVLQNRPL	OR6B1	41	O95007
LLQQLRPQNSLLRLL	PHF24	276	Q9UPV7
GIVLILLVRQLVQNL	SGPP2	331	Q8IWX5
LLVRQLVQNLSLQVL	SGPP2	336	Q8IWX5
NIRLLGRRPNLQQVT	BRINP2	121	Q9C0B6
QLLQLLQVDRQLRFP	CHST12	351	Q9NRB3
RQPILQLLTQLLQLD	NCAPD2	166	Q15021
PNVRIQAVLALSRLQ	NCAPG	156	Q9BPX3
QGLILNPIFRQNLRI	GTF2H4	106	Q92759
PELQTNVRSQILRLR	MRPS9	36	P82933
LRNALQELQQIIITP	SAMD4B	376	Q5PRF9
AILRLQVTNVLSQPL	RPN2	286	P04844
LQQQNQRLLVALREL	TPR	546	P12270
QNLICDNLLPRRNLL	RYR3	616	Q15413
QRLQIQLPDSVNQLL	TMEM214	596	Q6NUQ4
LRPQLGNLLQVNRTL	PHC1	151	P78364
RPQALSTNLQLARLV	TRIM72	61	Q6ZMU5
RQRLQSNALLVQLPE	SNX10	61	Q9Y5X0
VLFTRQRLSIQPLTQ	THYN1	196	Q9P016
VQQLIQRLRLIKSPA	XPNPEP3	236	Q9NQH7
NNVVPRINTLILRTN	UGGT2	676	Q9NYU1
RVPHLQILILNQNRF	TLR5	446	O60602
LQEQLRLQLPVFLQQ	UBQLN4	436	Q9NRR5
RIIPLQLQRLFAQLL	USP40	91	Q9NVE5
PLRLITNQGRIQIAL	UHRF1BP1	206	Q6BDS2
LQVALRQPIALNVRQ	VIRMA	441	Q69YN4
LNETQRLLLLQQGLL	TYRO3	871	Q06418
QRLAPLLLVLAQLIN	UGGT1	1001	Q9NYU2
LNTNLVTQLNIPARI	ZFP90	166	Q8TF47
PDSRLLQERQLQLQQ	KMT2D	3711	O14686
FLLNLRRQLPQNVLD	MYO1C	816	O00159