Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	AGAP5 STARD8 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	2.26e-10	279	70	12	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RASGRP4 AGAP5 STARD8 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.98e-08	507	70	13	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RASGRP4 AGAP5 STARD8 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.98e-08	507	70	13	GO:0030695
GeneOntologyMolecularFunction	lipid binding	RASGRP4 AGAP5 SCAP STARD8 DEFB119 SLC22A2 RNF34 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 RPH3A RASAL1 ASAP1 AGAP1 ITPR1	3.67e-08	988	70	17	GO:0008289
GeneOntologyMolecularFunction	phospholipid binding	AGAP5 RNF34 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 RPH3A RASAL1 ASAP1 AGAP1 ITPR1	4.04e-07	548	70	12	GO:0005543
GeneOntologyMolecularFunction	enzyme activator activity	AGAP5 STARD8 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	2.66e-06	656	70	12	GO:0008047
GeneOntologyMolecularFunction	P-type divalent copper transporter activity	ATP7A ATP7B	1.21e-05	2	70	2	GO:0043682
GeneOntologyMolecularFunction	P-type monovalent copper transporter activity	ATP7A ATP7B	1.21e-05	2	70	2	GO:0140581
GeneOntologyMolecularFunction	GTPase activity	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	2.50e-05	341	70	8	GO:0003924
GeneOntologyMolecularFunction	propionate-CoA ligase activity	ACSS1 ACSS2	7.24e-05	4	70	2	GO:0050218
GeneOntologyMolecularFunction	short-chain fatty acid-CoA ligase activity	ACSS1 ACSS2	7.24e-05	4	70	2	GO:0031955
GeneOntologyMolecularFunction	acetate-CoA ligase activity	ACSS1 ACSS2	7.24e-05	4	70	2	GO:0003987
GeneOntologyMolecularFunction	GTP binding	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	7.32e-05	397	70	8	GO:0005525
GeneOntologyMolecularFunction	molecular function activator activity	IL10 AGAP5 STARD8 STC2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	8.08e-05	1233	70	14	GO:0140677
GeneOntologyMolecularFunction	guanyl ribonucleotide binding	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	1.47e-04	439	70	8	GO:0032561
GeneOntologyMolecularFunction	guanyl nucleotide binding	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	1.47e-04	439	70	8	GO:0019001
GeneOntologyMolecularFunction	copper ion transmembrane transporter activity	ATP7A ATP7B	3.35e-04	8	70	2	GO:0005375
GeneOntologyMolecularFunction	enzyme regulator activity	RASGRP4 AGAP5 STARD8 AGAP11 AGAP9 AGAP7P BIRC6 AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	3.48e-04	1418	70	14	GO:0030234
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	AGAP5 ATP7A ATP7B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	3.53e-04	775	70	10	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	AGAP5 ATP7A ATP7B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	6.56e-04	839	70	10	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	AGAP5 ATP7A ATP7B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	6.62e-04	840	70	10	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	AGAP5 ATP7A ATP7B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	6.62e-04	840	70	10	GO:0016818
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	RPH3A ITPR1	1.07e-03	14	70	2	GO:0070679
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9B1 SLC9A6	1.41e-03	16	70	2	GO:0015385
GeneOntologyMolecularFunction	AMP binding	ACSS1 ACSS2	2.44e-03	21	70	2	GO:0016208
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSS1 ACSS2	3.73e-03	26	70	2	GO:0015645
GeneOntologyMolecularFunction	cullin family protein binding	KLHL9 KLHL13	3.73e-03	26	70	2	GO:0097602
GeneOntologyMolecularFunction	CoA-ligase activity	ACSS1 ACSS2	4.02e-03	27	70	2	GO:0016405
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC9B1 SLC9A6	4.02e-03	27	70	2	GO:0051139
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSS1 ACSS2	5.28e-03	31	70	2	GO:0016878
GeneOntologyMolecularFunction	alcohol binding	SCAP RPH3A ITPR1	5.53e-03	102	70	3	GO:0043178
GeneOntologyBiologicalProcess	activation of GTPase activity	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	3.00e-09	109	69	8	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 ASAP1 AGAP1 AGAP3	8.23e-09	244	69	10	GO:0043547
GeneOntologyBiologicalProcess	regulation of GTPase activity	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.39e-08	335	69	11	GO:0043087
GeneOntologyBiologicalProcess	regulation of hydrolase activity	AGAP5 SLC22A2 RNF34 AGAP11 AGAP9 AGAP7P BIRC6 AGAP4 AGAP6 NOS3 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.60e-07	878	69	15	GO:0051336
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	AGAP5 SLC22A2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 ASAP1 AGAP1 AGAP3	7.65e-07	499	69	11	GO:0051345
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	AGAP5 ATP7A ADRB3 SLC22A2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 NOS3 PREX2 ADCY8 ASAP1 AGAP1 AGAP3	1.18e-06	1028	69	15	GO:0043085
GeneOntologyBiologicalProcess	propionate biosynthetic process	ACSS1 ACSS2	1.10e-05	2	69	2	GO:0019542
GeneOntologyBiologicalProcess	acetate biosynthetic process	ACSS1 ACSS2	1.10e-05	2	69	2	GO:0019413
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process from acetate	ACSS1 ACSS2	1.10e-05	2	69	2	GO:0019427
GeneOntologyBiologicalProcess	positive regulation of molecular function	IL10 AGAP5 ATP7A ADRB3 SLC22A2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 NOS3 PREX2 ADCY8 ASAP1 AGAP1 AGAP3	1.50e-05	1430	69	16	GO:0044093
GeneOntologyBiologicalProcess	copper ion export	ATP7A ATP7B	3.30e-05	3	69	2	GO:0060003
GeneOntologyBiologicalProcess	short-chain fatty acid biosynthetic process	ACSS1 ACSS2	6.59e-05	4	69	2	GO:0051790
GeneOntologyBiologicalProcess	acetate metabolic process	ACSS1 ACSS2	6.59e-05	4	69	2	GO:0006083
GeneOntologyBiologicalProcess	regulation of superoxide dismutase activity	ATP7A SZT2	1.10e-04	5	69	2	GO:1901668
GeneOntologyBiologicalProcess	propionate metabolic process	ACSS1 ACSS2	1.10e-04	5	69	2	GO:0019541
GeneOntologyBiologicalProcess	copper ion import	ATP7A ATP7B	3.91e-04	9	69	2	GO:0015677
GeneOntologyBiologicalProcess	copper ion transmembrane transport	ATP7A ATP7B	3.91e-04	9	69	2	GO:0035434
HumanPheno	Pulmonary embolism	IL10 THBD MTHFR SMAD4	7.45e-06	43	16	4	HP:0002204
MousePheno	fused cornea and lens	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	3.23e-12	24	55	7	MP:0001307
MousePheno	abnormal lens development	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.09e-08	78	55	7	MP:0005545
MousePheno	increased circulating potassium level	AGAP5 P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.16e-08	121	55	8	MP:0005627
MousePheno	abnormal skin coloration	AGAP5 ATP7A PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	3.35e-08	182	55	9	MP:0011239
MousePheno	absent pinna reflex	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	5.29e-08	89	55	7	MP:0006358
MousePheno	abnormal pinna reflex	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.27e-07	101	55	7	MP:0001485
MousePheno	abnormal circulating potassium level	AGAP5 P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	3.18e-07	171	55	8	MP:0002668
MousePheno	abnormal uvea morphology	IL10 AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 ITPR1	3.69e-07	241	55	9	MP:0005197
MousePheno	abnormal snout morphology	AGAP5 P3H2 PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	6.34e-07	257	55	9	MP:0000443
MousePheno	abnormal iris morphology	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 ITPR1	7.67e-07	192	55	8	MP:0001322
MousePheno	abnormal potassium level	AGAP5 P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	8.97e-07	196	55	8	MP:0020887
MousePheno	abnormal potassium ion homeostasis	AGAP5 P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	9.68e-07	198	55	8	MP:0011978
MousePheno	abnormal anterior uvea morphology	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 ITPR1	1.01e-06	199	55	8	MP:0005194
MousePheno	cornea opacity	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.77e-06	159	55	7	MP:0001314
MousePheno	abnormal kidney copper level	ATP7A ATP7B	1.52e-05	2	55	2	MP:0010242
MousePheno	increased kidney copper level	ATP7A ATP7B	1.52e-05	2	55	2	MP:0010243
MousePheno	increased brain copper level	ATP7A ATP7B	1.52e-05	2	55	2	MP:0011214
MousePheno	persistence of hyaloid vascular system	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.53e-05	223	55	7	MP:0001289
MousePheno	abnormal jaw morphology	IL10 AGAP5 PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	3.54e-05	530	55	10	MP:0000454
MousePheno	decreased liver copper level	ATP7A ATP7B	4.55e-05	3	55	2	MP:0003067
MousePheno	decreased circulating copper level	ATP7A ATP7B	4.55e-05	3	55	2	MP:0006349
MousePheno	increased copper level	ATP7A ATP7B	9.07e-05	4	55	2	MP:0014539
MousePheno	abnormal circulating copper level	ATP7A ATP7B	9.07e-05	4	55	2	MP:0006348
MousePheno	abnormal viscerocranium morphology	IL10 AGAP5 PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	9.10e-05	593	55	10	MP:0005274
MousePheno	decreased copper level	ATP7A ATP7B	1.51e-04	5	55	2	MP:0014540
MousePheno	abnormal brain copper level	ATP7A ATP7B	1.51e-04	5	55	2	MP:0011213
MousePheno	abnormal liver copper level	ATP7A ATP7B	2.26e-04	6	55	2	MP:0003065
MousePheno	abnormal tooth morphology	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.35e-04	318	55	7	MP:0002100
MousePheno	abnormal dental arch morphology	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.39e-04	319	55	7	MP:0030254
MousePheno	abnormal circulating mineral level	IL10 AGAP5 ATP7A ATP7B P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 NOS3 AGAP1	3.53e-04	982	55	12	MP:0006357
MousePheno	abnormal auditory brainstem response	AGAP5 LCORL AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	3.75e-04	576	55	9	MP:0004738
MousePheno	abnormal hearing electrophysiology	AGAP5 LCORL AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	4.70e-04	594	55	9	MP:0006335
MousePheno	abnormal cornea morphology	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	5.48e-04	366	55	7	MP:0001312
MousePheno	abnormal copper level	ATP7A ATP7B	6.70e-04	10	55	2	MP:0003952
MousePheno	increased circulating mineral level	AGAP5 ATP7B P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	6.86e-04	626	55	9	MP:0014547
MousePheno	abnormal mineral level	IL10 AGAP5 ATP7A ATP7B P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 NOS3 AGAP1	7.40e-04	1066	55	12	MP:0000192
MousePheno	abnormal mineral homeostasis	IL10 AGAP5 ATP7A ATP7B P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 NOS3 AGAP1	8.04e-04	1076	55	12	MP:0005636
MousePheno	abnormal copper homeostasis	ATP7A ATP7B	8.17e-04	11	55	2	MP:0003951
MousePheno	alveolar process atrophy	IL10 PFAS	8.17e-04	11	55	2	MP:0030466
MousePheno	abnormal hearing physiology	AGAP5 LCORL AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	8.31e-04	643	55	9	MP:0001963
MousePheno	increased mineral level	AGAP5 ATP7B P3H2 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.09e-03	668	55	9	MP:0014535
MousePheno	abnormal mouth morphology	IL10 AGAP5 PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.11e-03	670	55	9	MP:0000452
MousePheno	abnormal cranium morphology	IL10 AGAP5 PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	1.13e-03	813	55	10	MP:0000438
MousePheno	abnormal craniofacial bone morphology	IL10 AGAP5 PFAS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	1.28e-03	827	55	10	MP:0002116
MousePheno	abnormal ear physiology	AGAP5 LCORL AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1	1.28e-03	684	55	9	MP:0003878
MousePheno	small ectoplacental cone	THBD SMAD4	1.34e-03	14	55	2	MP:0002584
MousePheno	abnormal vitreous body morphology	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.39e-03	429	55	7	MP:0002699
Domain	ArfGap	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	1.20e-15	29	73	9	SM00105
Domain	ArfGap	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	1.20e-15	29	73	9	PF01412
Domain	ARFGAP	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	1.20e-15	29	73	9	PS50115
Domain	ArfGAP	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	1.20e-15	29	73	9	IPR001164
Domain	PH	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.03e-08	278	73	11	SM00233
Domain	PH_DOMAIN	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.06e-08	279	73	11	PS50003
Domain	PH_domain	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	1.10e-08	280	73	11	IPR001849
Domain	Ankyrin_rpt-contain_dom	AGAP5 ANKRD30A AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	5.31e-08	254	73	10	IPR020683
Domain	ANK_REP_REGION	AGAP5 ANKRD30A AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	5.31e-08	254	73	10	PS50297
Domain	-	AGAP5 ANKRD30A AGAP11 AGAP9 AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	5.14e-07	248	73	9	1.25.40.20
Domain	ANK	AGAP5 ANKRD30A AGAP11 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	5.69e-07	251	73	9	SM00248
Domain	ANK_REPEAT	AGAP5 ANKRD30A AGAP11 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	6.08e-07	253	73	9	PS50088
Domain	PH_dom-like	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	7.63e-07	426	73	11	IPR011993
Domain	Ankyrin_rpt	AGAP5 ANKRD30A AGAP11 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	8.14e-07	262	73	9	IPR002110
Domain	Ank_2	AGAP5 ANKRD30A AGAP11 AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	1.91e-06	215	73	8	PF12796
Domain	-	AGAP5 AGAP11 AGAP9 AGAP4 AGAP6 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	2.77e-06	391	73	10	2.30.29.30
Domain	PH	AGAP11 AGAP7P AGAP4 PREX2 RASAL1 ASAP1 AGAP1 AGAP3	3.06e-06	229	73	8	PF00169
Domain	HMA_Cu_ion-bd	ATP7A ATP7B	1.51e-05	2	73	2	IPR006122
Domain	P-typ_ATPase_IB	ATP7A ATP7B	1.51e-05	2	73	2	IPR027256
Domain	Ac_CoA_lig	ACSS1 ACSS2	1.51e-05	2	73	2	IPR011904
Domain	Ank	ANKRD30A AGAP11 AGAP7P AGAP4 ASAP1 AGAP1 AGAP3	3.03e-05	228	73	7	PF00023
Domain	Heavy-metal-associated_CS	ATP7A ATP7B	4.51e-05	3	73	2	IPR017969
Domain	ACAS_N	ACSS1 ACSS2	9.00e-05	4	73	2	PF16177
Domain	ACAS_N	ACSS1 ACSS2	9.00e-05	4	73	2	IPR032387
Domain	HMA	ATP7A ATP7B	9.00e-05	4	73	2	PF00403
Domain	HMA_2	ATP7A ATP7B	9.00e-05	4	73	2	PS50846
Domain	HMA_1	ATP7A ATP7B	9.00e-05	4	73	2	PS01047
Domain	HMA_dom	ATP7A ATP7B	3.12e-04	7	73	2	IPR006121
Domain	Roc	AGAP1 AGAP3	1.14e-03	13	73	2	PF08477
Domain	MIRO-like	AGAP1 AGAP3	1.14e-03	13	73	2	IPR013684
Domain	Na_H_Exchanger	SLC9B1 SLC9A6	1.33e-03	14	73	2	PF00999
Domain	Cation/H_exchanger	SLC9B1 SLC9A6	1.33e-03	14	73	2	IPR006153
Domain	AMP-bd_C	ACSS1 ACSS2	1.97e-03	17	73	2	IPR025110
Domain	AMP-binding_C	ACSS1 ACSS2	1.97e-03	17	73	2	PF13193
Domain	AMP-binding_CS	ACSS1 ACSS2	4.61e-03	26	73	2	IPR020845
Domain	-	KLHL9 KLHL13	4.96e-03	27	73	2	2.130.10.80
Domain	AMP_BINDING	ACSS1 ACSS2	5.33e-03	28	73	2	PS00455
Domain	AMP-binding	ACSS1 ACSS2	6.11e-03	30	73	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSS1 ACSS2	6.11e-03	30	73	2	IPR000873
Domain	-	ATP7A ATP7B	6.93e-03	32	73	2	3.40.1110.10
Domain	-	ATP7A ATP7B	6.93e-03	32	73	2	2.70.150.10
Domain	Gal_Oxidase_b-propeller	KLHL9 KLHL13	7.80e-03	34	73	2	IPR015916
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	2.55e-21	9	74	8	12640130
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	4.66e-20	11	74	8	15381706
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.76e-17	10	74	7	20664521
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	2.50e-16	13	74	7	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	5.00e-16	14	74	7	22453919
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 RASAL1 ASAP1 AGAP1	9.02e-09	281	74	9	28706196
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AGAP5 KLHL9 SZT2 SMG5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.83e-07	529	74	10	14621295
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	AGAP5 AGAP11 AGAP9 AGAP4 AGAP6 AGAP1	1.86e-07	116	74	6	30652415
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 RPH3A AGAP1 AGAP3	3.37e-07	430	74	9	32581705
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	4.35e-07	218	74	7	33378226
Pubmed	A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).	IL10 THBD ADRB3 MTHFR NOS3	8.07e-07	80	74	5	19420105
Pubmed	The genomic basis of cerebral palsy: a HuGE systematic literature review.	IL10 THBD MTHFR NOS3	8.34e-07	34	74	4	19238444
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	AGAP5 UMPS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 ITPR1	2.08e-06	536	74	9	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	AGAP5 UMPS AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 ITPR1	2.15e-06	538	74	9	10512203
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1 AGAP3	2.43e-06	405	74	8	38187761
Pubmed	Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.	ADRB3 MTHFR NOS3	3.31e-06	14	74	3	20078877
Pubmed	Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.	IL10 ADRB3 MTHFR NOS3	3.72e-06	49	74	4	18936436
Pubmed	Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy.	ATP7A ATP7B	4.47e-06	2	74	2	29394468
Pubmed	Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels.	ATP7A ATP7B	4.47e-06	2	74	2	8082762
Pubmed	Distribution of the Trp64Arg polymorphism in the ß 3-adrenergic receptor gene in athletes and its influence on cardiovascular function.	ADRB3 NOS3	4.47e-06	2	74	2	20730725
Pubmed	Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.	ATP7A ATP7B	4.47e-06	2	74	2	19645496
Pubmed	Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta.	ATP7A ATP7B	4.47e-06	2	74	2	21115196
Pubmed	Exercise protects against myocardial ischemia-reperfusion injury via stimulation of β(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols.	ADRB3 NOS3	4.47e-06	2	74	2	21527738
Pubmed	A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays.	MTHFR NOS3	4.47e-06	2	74	2	22594584
Pubmed	Mechanisms of charge transfer in human copper ATPases ATP7A and ATP7B.	ATP7A ATP7B	4.47e-06	2	74	2	28164426
Pubmed	Biochemical basis of regulation of human copper-transporting ATPases.	ATP7A ATP7B	4.47e-06	2	74	2	17562324
Pubmed	Genes regulating copper metabolism.	ATP7A ATP7B	4.47e-06	2	74	2	9823011
Pubmed	Methylentetrahydrofolate reductase and nitric oxide synthase polymorphism in patients with atherosclerosis and diabetes.	MTHFR NOS3	4.47e-06	2	74	2	19330466
Pubmed	Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes.	ATP7A ATP7B	4.47e-06	2	74	2	17717039
Pubmed	The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma.	ACSS1 ACSS2	4.47e-06	2	74	2	19617323
Pubmed	Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.	ATP7A ATP7B	4.47e-06	2	74	2	20045993
Pubmed	Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	4.47e-06	2	74	2	38032054
Pubmed	Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.	ACSS1 ACSS2	4.47e-06	2	74	2	11150295
Pubmed	Molecular features of copper binding proteins involved in copper homeostasis.	ATP7A ATP7B	4.47e-06	2	74	2	27896900
Pubmed	Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.	MTHFR NOS3	4.47e-06	2	74	2	19913857
Pubmed	No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss.	MTHFR NOS3	4.47e-06	2	74	2	15214944
Pubmed	TGF-β/SMAD4 signaling pathway activates the HAS2-HA system to regulate granulosa cell state.	HAS2 SMAD4	4.47e-06	2	74	2	31489963
Pubmed	Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.	ATP7A ATP7B	4.47e-06	2	74	2	28271598
Pubmed	[Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases].	ATP7A ATP7B	4.47e-06	2	74	2	21117320
Pubmed	The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk.	MTHFR NOS3	4.47e-06	2	74	2	17479212
Pubmed	[From gene to disease: copper-transporting P ATPases alteration].	ATP7A ATP7B	4.47e-06	2	74	2	19046832
Pubmed	Association between Glu298Asp/677C-T single nucleotide polymorphism in the eNOS/MTHRF gene and blood stasis syndrome of ischemic stroke.	MTHFR NOS3	4.47e-06	2	74	2	22940147
Pubmed	beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility.	ADRB3 NOS3	4.47e-06	2	74	2	10974023
Pubmed	Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b.	ATP7A ATP7B	4.47e-06	2	74	2	12372948
Pubmed	Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells.	ATP7A ATP7B	4.47e-06	2	74	2	18565219
Pubmed	Copper transporting P-type ATPases and human disease.	ATP7A ATP7B	4.47e-06	2	74	2	12539960
Pubmed	Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS.	NOS3 SMAD4	4.47e-06	2	74	2	31916354
Pubmed	Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.	ATP7A ATP7B	4.47e-06	2	74	2	17109627
Pubmed	Quantitative relationship between mutated amino-acid sequence of human copper-transporting ATPases and their related diseases.	ATP7A ATP7B	4.47e-06	2	74	2	18688737
Pubmed	IL-10 promotes malignant pleural effusion by regulating TH 1 response via an miR-7116-5p/GPR55/ERK pathway in mice.	IL10 GPR55	4.47e-06	2	74	2	32506440
Pubmed	Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke.	MTHFR NOS3	4.47e-06	2	74	2	26187788
Pubmed	Expression and localization of menkes and Wilson copper transporting ATPases in human placenta.	ATP7A ATP7B	4.47e-06	2	74	2	15135234
Pubmed	Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters.	ATP7A ATP7B	4.47e-06	2	74	2	9215673
Pubmed	Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins.	ATP7A ATP7B	4.47e-06	2	74	2	18000748
Pubmed	[Polimorfismos asociados a disfunción endotelial y a un estado protrombótico en jóvenes mexicanos con infarto cerebral].	MTHFR NOS3	4.47e-06	2	74	2	30532099
Pubmed	Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.	ACSS1 ACSS2	4.47e-06	2	74	2	27539851
Pubmed	Menkes disease: recent advances and new insights into copper metabolism.	ATP7A ATP7B	4.47e-06	2	74	2	8732640
Pubmed	Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients.	MTHFR NOS3	4.47e-06	2	74	2	21380725
Pubmed	Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease.	MTHFR NOS3	4.47e-06	2	74	2	19376104
Pubmed	Arf GAPs and molecular motors.	ASAP1 AGAP1	4.47e-06	2	74	2	28430047
Pubmed	Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.	ATP7A ATP7B	4.47e-06	2	74	2	17531189
Pubmed	Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.	ATP7A ATP7B	4.47e-06	2	74	2	17928409
Pubmed	The 894G > T (Glu298Asp) variant in the endothelial NOS gene and MTHFR polymorphisms influence homocysteine levels in patients with cognitive decline.	MTHFR NOS3	4.47e-06	2	74	2	21607713
Pubmed	N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.	SCAP ACSS2	4.47e-06	2	74	2	38591127
Pubmed	Effects of six functional SNPs on the urinary 8-isoprostane level in a general Japanese population; Shimane COHRE Study.	MTHFR NOS3	4.47e-06	2	74	2	21725157
Pubmed	Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.	IL10 ADRB3 MTHFR NOS3	5.51e-06	54	74	4	20536507
Pubmed	Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.	IL10 ADRB3 MTHFR NOS3	6.85e-06	57	74	4	19479237
Pubmed	A systematic meta-analysis of genetic association studies for diabetic retinopathy.	ADRB3 MTHFR NOS3	1.03e-05	20	74	3	19587357
Pubmed	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	IL10 ADRB3 MTHFR NOS3	1.09e-05	64	74	4	19131662
Pubmed	Candidate genes and cerebral palsy: a population-based study.	THBD MTHFR NOS3	1.20e-05	21	74	3	18977990
Pubmed	[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].	MTHFR NOS3	1.34e-05	3	74	2	22997914
Pubmed	Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose.	THBD NOS3	1.34e-05	3	74	2	32382091
Pubmed	TGF-β signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE.	IL10 SMAD4	1.34e-05	3	74	2	21728174
Pubmed	Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.	THBD NOS3	1.34e-05	3	74	2	16043642
Pubmed	The Role of the IL-10 (-819C/T), TNFA (-308G/A) and ENOS (-786T/C) Polymorphisms of Impulsive and Aggressive Personality Traits in Cocaine/Crack Users.	IL10 NOS3	1.34e-05	3	74	2	35716966
Pubmed	Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10).	IL10 THBD	1.34e-05	3	74	2	30842629
Pubmed	Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.	MTHFR NOS3	1.34e-05	3	74	2	15494775
Pubmed	Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.	ATP7A ATP7B	1.34e-05	3	74	2	28737129
Pubmed	ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.	ATP7A ATP7B	1.34e-05	3	74	2	30341172
Pubmed	The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.	ATP7A ATP7B	1.34e-05	3	74	2	15634671
Pubmed	Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.	ATP7A ATP7B	1.34e-05	3	74	2	10557326
Pubmed	Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility.	MTHFR NOS3	1.34e-05	3	74	2	17551576
Pubmed	Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.	ACSS1 ACSS2	1.34e-05	3	74	2	16788062
Pubmed	Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.	MTHFR NOS3	1.34e-05	3	74	2	19049547
Pubmed	Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.	ATP7A ATP7B	1.34e-05	3	74	2	20566629
Pubmed	Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p.	ATP7A ATP7B	1.34e-05	3	74	2	10497213
Pubmed	Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease.	MTHFR NOS3	1.34e-05	3	74	2	17000887
Pubmed	The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke.	MTHFR NOS3	1.34e-05	3	74	2	18602910
Pubmed	β3-Adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation.	ADRB3 NOS3	1.34e-05	3	74	2	24911015
Pubmed	The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults.	MTHFR NOS3	1.34e-05	3	74	2	19349296
Pubmed	Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases.	ATP7A ATP7B	1.34e-05	3	74	2	16884690
Pubmed	Intestinal expression of metal transporters in Wilson's disease.	ATP7A ATP7B	1.34e-05	3	74	2	23963605
Pubmed	Association between genetic and environmental factors and the risk of Alzheimer's disease.	MTHFR NOS3	1.34e-05	3	74	2	19169966
Pubmed	Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.	MTHFR NOS3	1.34e-05	3	74	2	21169404
Pubmed	[Endothelial dysfunction gene polymorphisms and the rate of liver fibrosis in chronic hepatitis C].	MTHFR NOS3	1.34e-05	3	74	2	24864467
Pubmed	Interaction among 5,10 methylenetetrahydrofolate reductase, plasminogen activator inhibitor and endothelial nitric oxide synthase gene polymorphisms predicts the severity of coronary artery disease in Turkish patients.	MTHFR NOS3	1.34e-05	3	74	2	16845248
Pubmed	Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.34e-05	3	74	2	21242307
Pubmed	Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.	ATP7A ATP7B	1.34e-05	3	74	2	23751120
Pubmed	Targeting Cul3-scaffold E3 ligase complex via KLHL substrate adaptors for cancer therapy.	KLHL9 KLHL13	1.34e-05	3	74	2	33872809
Pubmed	[Prognostic value of allelic variants affecting the hemostatic system in the development of antiphospholipid syndrome and kidney lesion in patients with systemic lupus erythematosus].	MTHFR NOS3	1.34e-05	3	74	2	25095657
Interaction	TSPAN16 interactions	SCAP ATP7A ATP7B TSPAN16	1.10e-06	22	73	4	int:TSPAN16
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	AGAP9 AGAP7P AGAP4 AGAP6	2.51e-04	188	74	4	chr10q11
Cytoband	2q37	GPR55 AGAP1	1.16e-03	31	74	2	2q37
Cytoband	10q11.23	AGAP7P AGAP6	1.31e-03	33	74	2	10q11.23
Cytoband	4q24	SLC9B1 DDIT4L	1.39e-03	34	74	2	4q24
Cytoband	10q11.22	AGAP9 AGAP4	2.02e-03	41	74	2	10q11.22
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP11 AGAP9 AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	6.35e-17	17	52	8	1291
GeneFamily	ArfGAPs	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	2.37e-16	33	52	9	395
GeneFamily	Ankyrin repeat domain containing	AGAP5 ANKRD30A AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 ASAP1 AGAP1 AGAP3	1.48e-09	242	52	10	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6 RASAL1 ASAP1 AGAP1 AGAP3	6.54e-09	206	52	9	682
GeneFamily	ATPase copper transporting	ATP7A ATP7B	8.11e-06	2	52	2	1212
GeneFamily	Acyl-CoA synthetase family	ACSS1 ACSS2	2.52e-03	26	52	2	40
GeneFamily	Solute carriers	SLC9B1 SLC22A2 SLC25A47 SLC9A6 SLC23A3	5.43e-03	395	52	5	752
GeneFamily	Kelch like\|BTB domain containing	KLHL9 KLHL13	6.49e-03	42	52	2	617
GeneFamily	Olfactory receptors, family 8	OR8G5 OR8G1	8.75e-03	49	52	2	155
Coexpression	THEODOROU_MAMMARY_TUMORIGENESIS	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	8.43e-12	37	72	7	MM1121
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	3.09e-11	44	72	7	MM485
Coexpression	CHYLA_CBFA2T3_TARGETS_DN	AGAP5 ATP7B AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	6.35e-07	263	72	8	MM1295
Coexpression	KARLSSON_TGFB1_TARGETS_DN	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	1.76e-06	209	72	7	MM1058
Coexpression	CHEBOTAEV_GR_TARGETS_UP	STC2 LCORL DDIT4L ITPR1	6.09e-05	77	72	4	M4263
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBD STARD8 STC2 NOS3 PREX2 ASAP1	1.03e-06	200	74	6	9f889f7ff0b3ba2750aa757b94680a9f7014fd0d
ToppCell	Tracheal-10x5prime-Endothelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBD STARD8 STC2 NOS3 PREX2 ASAP1	1.03e-06	200	74	6	71ba0e48ca4ded077f2b96a0cf4f2331f2e25d15
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBD STARD8 STC2 NOS3 PREX2	1.88e-05	196	74	5	f0b106078212be1d0938f545707a004a1e830857
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THBD STARD8 NOS3 PREX2 ASAP1	1.93e-05	197	74	5	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THBD STARD8 NOS3 PREX2 ASAP1	1.93e-05	197	74	5	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBD STC2 NOS3 PREX2 ASAP1	2.07e-05	200	74	5	06ffa5baad3e699cf66d8b2c7513649e1d2c7e62
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP11 AGAP9 AGAP7P AGAP4 AGAP6 AGAP1	3.33e-17	10	69	7	DOID:1969 (implicated_via_orthology)
Disease	occipital horn syndrome (implicated_via_orthology)	ATP7A ATP7B	5.39e-06	2	69	2	DOID:0111272 (implicated_via_orthology)
Disease	diabetic retinopathy (is_implicated_in)	IL10 ADRB3 MTHFR NOS3	5.81e-06	50	69	4	DOID:8947 (is_implicated_in)
Disease	Malignant neoplasm of breast	IL10 STARD8 ATP7B STC2 MTHFR P3H2 ANKRD30A UMPS ZDHHC4 GEN1 EIF6 NOS3	6.61e-06	1074	69	12	C0006142
Disease	Diabetic Angiopathies	MTHFR NOS3 ADCY8	6.71e-06	16	69	3	C0011875
Disease	Microangiopathy, Diabetic	MTHFR NOS3 ADCY8	6.71e-06	16	69	3	C0025945
Disease	rheumatoid arthritis (is_implicated_in)	IL10 THBD ADRB3 MTHFR	1.06e-05	58	69	4	DOID:7148 (is_implicated_in)
Disease	Mammary Carcinoma, Human	IL10 STARD8 ATP7B STC2 MTHFR UMPS EIF6 NOS3	3.07e-05	525	69	8	C4704874
Disease	Mammary Neoplasms, Human	IL10 STARD8 ATP7B STC2 MTHFR UMPS EIF6 NOS3	3.07e-05	525	69	8	C1257931
Disease	Mammary Neoplasms	IL10 STARD8 ATP7B STC2 MTHFR UMPS EIF6 NOS3	3.16e-05	527	69	8	C1458155
Disease	metal metabolism disorder (implicated_via_orthology)	ATP7A ATP7B	3.22e-05	4	69	2	DOID:896 (implicated_via_orthology)
Disease	aphthous stomatitis (is_implicated_in)	IL10 MTHFR	3.22e-05	4	69	2	DOID:9663 (is_implicated_in)
Disease	Breast Carcinoma	IL10 STARD8 ATP7B STC2 MTHFR UMPS EIF6 NOS3	3.65e-05	538	69	8	C0678222
Disease	Wilson disease (implicated_via_orthology)	ATP7A ATP7B	5.36e-05	5	69	2	DOID:893 (implicated_via_orthology)
Disease	Menkes disease (implicated_via_orthology)	ATP7A ATP7B	5.36e-05	5	69	2	DOID:1838 (implicated_via_orthology)
Disease	Graft-vs-Host Disease	IL10 MTHFR	8.03e-05	6	69	2	C0018133
Disease	coronary artery disease (is_implicated_in)	IL10 ADRB3 MTHFR NOS3	9.07e-05	100	69	4	DOID:3393 (is_implicated_in)
Disease	angle-closure glaucoma (is_implicated_in)	MTHFR NOS3	1.12e-04	7	69	2	DOID:13550 (is_implicated_in)
Disease	colitis (biomarker_via_orthology)	IL10 ADRB3 NOS3	1.32e-04	42	69	3	DOID:0060180 (biomarker_via_orthology)
Disease	adult respiratory distress syndrome (biomarker_via_orthology)	IL10 THBD	1.50e-04	8	69	2	DOID:11394 (biomarker_via_orthology)
Disease	Inflammatory disease of mucous membrane	IL10 MTHFR	1.50e-04	8	69	2	C0333355
Disease	spinal muscular atrophy (implicated_via_orthology)	ATP7A ATP7B	1.92e-04	9	69	2	DOID:12377 (implicated_via_orthology)
Disease	migraine (is_implicated_in)	MTHFR NOS3	1.92e-04	9	69	2	DOID:6364 (is_implicated_in)
Disease	Thrombophilia	THBD MTHFR	1.92e-04	9	69	2	C0398623
Disease	acute kidney failure (is_implicated_in)	THBD SLC22A2	2.40e-04	10	69	2	DOID:3021 (is_implicated_in)
Disease	factor VIII deficiency (is_implicated_in)	IL10 MTHFR	2.92e-04	11	69	2	DOID:12134 (is_implicated_in)
Disease	liver benign neoplasm (biomarker_via_orthology)	IL10 MTHFR	2.92e-04	11	69	2	DOID:916 (biomarker_via_orthology)
Disease	Pulmonary Thromboembolisms	THBD MTHFR	3.50e-04	12	69	2	C0524702
Disease	Pulmonary Embolism	THBD MTHFR	3.50e-04	12	69	2	C0034065
Disease	prostatitis (biomarker_via_orthology)	IL10 SMAD4	3.50e-04	12	69	2	DOID:14654 (biomarker_via_orthology)
Disease	lymphangioleiomyomatosis (is_marker_for)	ACSS2 NOS3	3.50e-04	12	69	2	DOID:3319 (is_marker_for)
Disease	attention function measurement	P3H2 ADCY8 ASAP1 ITPR1	4.08e-04	148	69	4	EFO_0007636
Disease	Colonic Neoplasms	ATP7A MTHFR RNF34 UMPS	4.51e-04	152	69	4	C0009375
Disease	pulmonary hypertension (is_marker_for)	IL10 THBD NOS3	4.60e-04	64	69	3	DOID:6432 (is_marker_for)
Disease	Colorectal Neoplasms	STARD8 ATP7B MTHFR UMPS SMAD4	4.84e-04	277	69	5	C0009404
Disease	asthma (is_implicated_in)	IL10 THBD MTHFR NOS3	5.10e-04	157	69	4	DOID:2841 (is_implicated_in)
Disease	Malignant tumor of colon	ATP7A MTHFR RNF34 UMPS	5.34e-04	159	69	4	C0007102
Disease	Benign Neoplasm	GPR55 BIRC6 NOS3	5.50e-04	68	69	3	C0086692
Disease	Neoplasms	GPR55 BIRC6 NOS3	5.50e-04	68	69	3	C0027651
Disease	Hereditary Diffuse Gastric Cancer	THBD MTHFR UMPS NOS3 SMAD4	6.24e-04	293	69	5	C1708349
Disease	atherosclerosis (is_implicated_in)	MTHFR NOS3	6.33e-04	16	69	2	DOID:1936 (is_implicated_in)
Disease	Huntington's disease (biomarker_via_orthology)	NOS3 ITPR1	6.33e-04	16	69	2	DOID:12858 (biomarker_via_orthology)
Disease	sickle cell anemia (is_implicated_in)	MTHFR NOS3	6.33e-04	16	69	2	DOID:10923 (is_implicated_in)
Disease	response to acetylsalicylate	DNAAF3 SCAP	6.33e-04	16	69	2	GO_1903492
Disease	Stomach Neoplasms	THBD MTHFR UMPS NOS3 SMAD4	6.63e-04	297	69	5	C0038356
Disease	Malignant neoplasm of stomach	THBD MTHFR UMPS NOS3 SMAD4	6.94e-04	300	69	5	C0024623
Disease	thrombomodulin measurement	THBD RPH3A	7.16e-04	17	69	2	EFO_0007774
Disease	Kuhnt-Junius degeneration (is_implicated_in)	MTHFR NOS3	7.16e-04	17	69	2	DOID:10873 (is_implicated_in)
Disease	Lipidemias	ADRB3 NOS3	7.16e-04	17	69	2	C1706412
Disease	graft-versus-host disease (is_implicated_in)	IL10 MTHFR	7.16e-04	17	69	2	DOID:0081267 (is_implicated_in)
Disease	Hyperlipidemia	ADRB3 NOS3	7.16e-04	17	69	2	C0020473
Disease	sphingosine 1-phosphate measurement	DNAAF3 ITPR1	8.05e-04	18	69	2	EFO_0800185
Disease	non-alcoholic fatty liver disease (is_implicated_in)	ADRB3 MTHFR	8.05e-04	18	69	2	DOID:0080208 (is_implicated_in)
Disease	hypothyroidism (biomarker_via_orthology)	IL10 MTHFR NOS3	8.84e-04	80	69	3	DOID:1459 (biomarker_via_orthology)
Disease	pulmonary hypertension (biomarker_via_orthology)	HAS2 NOS3 SMAD4	8.84e-04	80	69	3	DOID:6432 (biomarker_via_orthology)
Disease	inflammatory bowel disease (is_implicated_in)	IL10 MTHFR	8.98e-04	19	69	2	DOID:0050589 (is_implicated_in)
Disease	acetate measurement	ACSS1 ACSS2	9.96e-04	20	69	2	EFO_0010112
Disease	chronic myeloid leukemia (is_implicated_in)	IL10 MTHFR	1.10e-03	21	69	2	DOID:8552 (is_implicated_in)
Disease	mean arterial pressure	SZT2 LCORL MTHFR SLC25A47 NOS3 RPH3A	1.11e-03	499	69	6	EFO_0006340
Disease	Kidney Diseases	MTHFR SLC22A2 RASAL1	1.16e-03	88	69	3	C0022658
Disease	cholangiocarcinoma (is_implicated_in)	MTHFR PREX2	1.21e-03	22	69	2	DOID:4947 (is_implicated_in)
Disease	Colorectal Carcinoma	STARD8 ATP7B MTHFR UMPS PREX2 ADCY8 SMAD4	1.26e-03	702	69	7	C0009402
Disease	Septicemia	IL10 NOS3	1.44e-03	24	69	2	C0036690
Disease	Sepsis	IL10 NOS3	1.44e-03	24	69	2	C0243026
Disease	Severe Sepsis	IL10 NOS3	1.44e-03	24	69	2	C1719672
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	ATP7A NOS3	1.44e-03	24	69	2	DOID:3827 (biomarker_via_orthology)
Disease	Hepatolenticular Degeneration	IL10 ATP7B	1.44e-03	24	69	2	C0019202
Disease	Hepatic Form of Wilson Disease	IL10 ATP7B	1.44e-03	24	69	2	C1527352
Disease	Pyemia	IL10 NOS3	1.44e-03	24	69	2	C0034189
Disease	Myocardial Infarction	IL10 THBD NOS3	1.45e-03	95	69	3	C0027051
Disease	myocardial infarction (is_implicated_in)	IL10 MTHFR NOS3	1.63e-03	99	69	3	DOID:5844 (is_implicated_in)
Disease	response to antineoplastic agent	RPH3A ADCY8 ASAP1	1.63e-03	99	69	3	GO_0097327
Disease	Acute kidney injury	IL10 MTHFR NOS3	1.73e-03	101	69	3	C2609414
Disease	Acute Kidney Insufficiency	IL10 MTHFR NOS3	1.73e-03	101	69	3	C1565662
Disease	Kidney Failure, Acute	IL10 MTHFR NOS3	1.73e-03	101	69	3	C0022660
Disease	age at assessment, lateral ventricle volume change measurement	ADCY8 ASAP1	1.82e-03	27	69	2	EFO_0008007, EFO_0021502
Disease	thrombocytopenia (is_implicated_in)	IL10 MTHFR	1.82e-03	27	69	2	DOID:1588 (is_implicated_in)
Disease	acute kidney failure (implicated_via_orthology)	THBD SLC22A2	1.82e-03	27	69	2	DOID:3021 (implicated_via_orthology)
Disease	oral squamous cell carcinoma (is_implicated_in)	IL10 MTHFR	1.96e-03	28	69	2	DOID:0050866 (is_implicated_in)
Disease	hyperthyroidism (biomarker_via_orthology)	IL10 MTHFR	1.96e-03	28	69	2	DOID:7998 (biomarker_via_orthology)
Disease	stimulant use measurement	ADCY8 ASAP1	1.96e-03	28	69	2	EFO_0600076
Disease	congestive heart failure (biomarker_via_orthology)	IL10 ADRB3 NOS3	2.04e-03	107	69	3	DOID:6000 (biomarker_via_orthology)
Disease	cerebral infarction (is_implicated_in)	THBD MTHFR	2.10e-03	29	69	2	DOID:3526 (is_implicated_in)
Disease	chronic kidney disease	SLC22A2 HAS2 DCAF4 ADCY8	2.26e-03	235	69	4	EFO_0003884
Disease	coronary artery disease, factor VII measurement	UMPS NOS3 RPH3A	2.27e-03	111	69	3	EFO_0001645, EFO_0004619
Disease	pancreatic cancer (is_implicated_in)	IL10 MTHFR SMAD4	2.32e-03	112	69	3	DOID:1793 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRIGIHSGSVLCGVL	ADCY8	506	P40145
LGVLMCIECSGIHRS	AGAP4	471	Q96P64
LGALMCIECSGIHRH	AGAP3	656	Q96P47
GVLTLGLDMSCHACL	ERC2-IT1	51	O76042
HILLCLMGLAETPGC	DCAF4	241	Q8WV16
AMLACARIGAVHTVI	ACSS1	181	Q9NUB1
LNLGVLMCIECSGIH	AGAP11	356	Q8TF27
LMCIECSGIHRSLGT	AGAP11	361	Q8TF27
ALMCIECSGIHRNLG	AGAP1	641	Q9UPQ3
VLMCIECSGIHRSFG	AGAP9	541	Q5VTM2
LVLRDGCMHCDADGL	BIRC6	56	Q9NR09
LRIDGMHCKSCVLNI	ATP7B	261	P35670
LAVCHGSSEIVGMLL	ANKRD30A	211	Q9BXX3
CGLRGCVMHVNLEIE	DDIT4L	101	Q96D03
CCIVVKHLGRAELGM	ACSS2	246	Q9NR19
REHRALCTLGLIMGT	ADRB3	286	P13945
LGVLMCIECSGIHRS	AGAP6	471	Q5VW22
LELVVRGMTCASCVH	ATP7A	566	Q04656
LDMHSVTGIIVGVCL	IGDCC4	951	Q8TDY8
MLEDGQGRCLRCHVL	RASAL1	126	O95294
IGLVCASVHTGCMFR	OR8G1	151	Q15617
IGLICASAHIGCMFR	OR8G5	186	Q8NG78
GLETILHMTCCRQRL	MTHFR	121	P42898
MHSSALLCCLVLLTG	IL10	1	P22301
CETLLMCIVTVLSHG	ITPR1	2536	Q14643
MQALRHVVCALSGGV	TRMU	1	O75648
LEDCLMVGLHTCGDL	METTL25	376	Q8N6Q8
RLMHCVGFESILEGL	LCORL	46	Q8N3X6
LHSLNCLMVCDIRGT	HARBI1	171	Q96MB7
MAVTGGLCHSAISRL	RASGRP4	291	Q8TDF6
TVRGLHCMCTVGDKL	KLHL9	481	Q9P2J3
CRELHSVASGIMLVG	P3H2	476	Q8IVL5
GKRHILRCMGNSGIC	DEFB119	21	Q8N690
IMGFCCSRSIHILLG	GPR55	196	Q9Y2T6
HRVLCLERGHMFVCG	NOS3	1101	P29474
CRIIGRMCVGNRHGL	EIF6	56	P56537
LEMSSILRHCCDLIG	EBLN1	131	P0CF75
GLHCMCTVGERLYVI	KLHL13	526	Q9P2N7
ACGMVHLLIPELGAC	DNAAF3	386	Q8N9W5
TMIGCDRLIRIFCLH	FBXO15	281	Q8NCQ5
MHCERFLCILRIIGT	HAS2	1	Q92819
LGVLMCIECSGIHRS	AGAP7P	471	Q5VUJ5
ILTCIECSGIHREMG	ASAP1	471	Q9ULH1
KSVLRECLHMLECLG	GEN1	111	Q17RS7
GMLLVSCCLAGHVCV	SCAP	786	Q12770
GVHICSSMCDIGGII	SLC22A2	466	O15244
MVLCLLHSCLGQELS	SZT2	1031	Q5T011
HLCGMATDLALRCLV	TRMT13	266	Q9NUP7
ICDGLRGHLMTVRSS	THBD	51	P07204
LCALGMLAVAICSDH	TMEM178B	16	H3BS89
GLIVGIIRCVHLAAM	RPH3A	566	Q9Y2J0
GTTAMLSCLHIRVGV	SLC9A6	496	Q92581
MGHALCVCSRGTVII	STK16	1	O75716
ICLMCVHSLERAGSK	SMG5	361	Q9UPR3
GVVCRLSRSLQEHMG	TOGARAM2	951	Q6ZUX3
FCCSHLLGMVGQLER	PNPLA5	66	Q7Z6Z6
LCHSLLMLAGVVVSC	FAM178B	596	Q8IXR5
CLSIVHSLMCHRQGG	SMAD4	16	Q13485
RGLLHCMVTSVREEG	SLC25A47	256	Q6Q0C1
RHGLAVCLALTTMCT	ST6GALNAC5	6	Q9BVH7
MEPCGLGRSRLTHIC	STARD8	966	Q92502
VILLMVVCSQHLGSC	SLC23A3	226	Q6PIS1
VLMCIECSGIHRSLG	AGAP5	496	A6NIR3
HSLSMLGIGQCVECE	TOP3B	716	O95985
HVGNLCLVMGCITVL	TSPAN16	56	Q9UKR8
VLLECGHMVTCTKCG	RNF34	336	Q969K3
CEIRGLHGICMTFLH	STC2	76	O76061
VAGICSCDGRHLAVM	PFAS	1281	O15067
MGLVLICVCSKTHSL	ZDHHC4	16	Q9NPG8
LHRGCLLIAEMSSTG	UMPS	361	P11172
ICLGSGIMRDIAHLE	TTC14	146	Q96N46
LGACHIIMCSSGVHR	PREX2	1521	Q70Z35
IIMCSSGVHRCTLSV	PREX2	1526	Q70Z35
MCVSAVLGSQRIGLH	SLC9B1	326	Q4ZJI4
MLETCGLLVSLGHRV	ZNF550	41	Q7Z398
AHSCEMCGAILGDIL	ZNF418	81	Q8TF45