Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	4.35e-05	446	75	9	GO:0004674
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TLK2 TLK1 UCKL1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	6.47e-05	709	75	11	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	TLK2 TLK1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	7.96e-05	600	75	10	GO:0004672
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	HELZ2 ACTN4 ACTN1 ACTN2	8.15e-05	61	75	4	GO:0030374
GeneOntologyMolecularFunction	kinase activity	TLK2 TLK1 UCKL1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	1.26e-04	764	75	11	GO:0016301
GeneOntologyMolecularFunction	transcription coactivator activity	FIZ1 HELZ2 ACTN4 ACTN1 ACTN2 TRIM27 TFAP2A	1.42e-04	303	75	7	GO:0003713
GeneOntologyMolecularFunction	protein serine kinase activity	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 MAP3K21	4.26e-04	363	75	7	GO:0106310
GeneOntologyMolecularFunction	transmembrane transporter binding	ACTN4 ACTN1 ACTN2 ACTN3 HERPUD1	4.75e-04	172	75	5	GO:0044325
GeneOntologyMolecularFunction	integrin binding	LAMA5 ACTN4 ACTN1 ACTN2 ACTN3	5.13e-04	175	75	5	GO:0005178
GeneOntologyMolecularFunction	structural constituent of muscle	OBSCN ACTN2 ACTN3	5.64e-04	43	75	3	GO:0008307
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TLK2 TLK1 UCKL1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	7.22e-04	938	75	11	GO:0016772
GeneOntologyMolecularFunction	titin binding	OBSCN ACTN2	1.23e-03	14	75	2	GO:0031432
GeneOntologyMolecularFunction	actin filament binding	XIRP1 ACTN4 ACTN1 ACTN2 ACTN3	1.64e-03	227	75	5	GO:0051015
GeneOntologyCellularComponent	pseudopodium	ACTN4 ACTN1 ACTN2 ACTN3	4.75e-07	18	76	4	GO:0031143
GeneOntologyCellularComponent	platelet alpha granule lumen	TOR4A ACTN4 ACTN1 ACTN2	1.04e-04	67	76	4	GO:0031093
GeneOntologyCellularComponent	myofilament	OBSCN ACTN2 ACTN3	2.12e-04	32	76	3	GO:0036379
GeneOntologyCellularComponent	Z disc	OBSCN ACTN4 ACTN1 ACTN2 ACTN3	2.25e-04	151	76	5	GO:0030018
GeneOntologyCellularComponent	sarcomere	SIMC1 OBSCN ACTN4 ACTN1 ACTN2 ACTN3	2.93e-04	249	76	6	GO:0030017
GeneOntologyCellularComponent	I band	OBSCN ACTN4 ACTN1 ACTN2 ACTN3	3.49e-04	166	76	5	GO:0031674
GeneOntologyCellularComponent	cortical actin cytoskeleton	ACTN4 ACTN1 ACTN2 ACTN3	3.69e-04	93	76	4	GO:0030864
GeneOntologyCellularComponent	platelet alpha granule	TOR4A ACTN4 ACTN1 ACTN2	3.69e-04	93	76	4	GO:0031091
GeneOntologyCellularComponent	myofibril	SIMC1 OBSCN ACTN4 ACTN1 ACTN2 ACTN3	4.78e-04	273	76	6	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	SIMC1 OBSCN ACTN4 ACTN1 ACTN2 ACTN3	6.56e-04	290	76	6	GO:0043292
GeneOntologyCellularComponent	fascia adherens	XIRP1 ACTN1	9.91e-04	13	76	2	GO:0005916
GeneOntologyCellularComponent	cortical cytoskeleton	ACTN4 ACTN1 ACTN2 ACTN3	1.26e-03	129	76	4	GO:0030863
GeneOntologyCellularComponent	intercalated disc	XIRP1 OBSCN ACTN1	1.95e-03	68	76	3	GO:0014704
GeneOntologyCellularComponent	actin filament	ACTN1 ACTN2 ACTN3 POTEI	1.98e-03	146	76	4	GO:0005884
GeneOntologyCellularComponent	postsynaptic actin cytoskeleton	ACTN4 ACTN2	2.14e-03	19	76	2	GO:0098871
Domain	EF-hand_Ca_insen	ACTN4 ACTN1 ACTN2 ACTN3	3.38e-09	6	74	4	IPR014837
Domain	EFhand_Ca_insen	ACTN4 ACTN1 ACTN2 ACTN3	3.38e-09	6	74	4	PF08726
Domain	Actinin_actin-bd_CS	ACTN4 ACTN1 ACTN2 ACTN3	1.90e-06	23	74	4	IPR001589
Domain	Spectrin	ACTN4 ACTN1 ACTN2 ACTN3	1.90e-06	23	74	4	PF00435
Domain	ACTININ_2	ACTN4 ACTN1 ACTN2 ACTN3	1.90e-06	23	74	4	PS00020
Domain	ACTININ_1	ACTN4 ACTN1 ACTN2 ACTN3	1.90e-06	23	74	4	PS00019
Domain	Spectrin_repeat	ACTN4 ACTN1 ACTN2 ACTN3	5.00e-06	29	74	4	IPR002017
Domain	CH	EHBP1 ACTN4 ACTN1 ACTN2 ACTN3	5.84e-06	65	74	5	SM00033
Domain	Spectrin/alpha-actinin	ACTN4 ACTN1 ACTN2 ACTN3	7.51e-06	32	74	4	IPR018159
Domain	SPEC	ACTN4 ACTN1 ACTN2 ACTN3	7.51e-06	32	74	4	SM00150
Domain	CH	EHBP1 ACTN4 ACTN1 ACTN2 ACTN3	8.43e-06	70	74	5	PF00307
Domain	-	EHBP1 ACTN4 ACTN1 ACTN2 ACTN3	9.04e-06	71	74	5	1.10.418.10
Domain	CH	EHBP1 ACTN4 ACTN1 ACTN2 ACTN3	1.04e-05	73	74	5	PS50021
Domain	CH-domain	EHBP1 ACTN4 ACTN1 ACTN2 ACTN3	1.18e-05	75	74	5	IPR001715
Domain	Prot_kinase_dom	TLK2 TLK1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	2.21e-05	489	74	10	IPR000719
Domain	PROTEIN_KINASE_DOM	TLK2 TLK1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	2.37e-05	493	74	10	PS50011
Domain	Kinase-like_dom	TLK2 TLK1 GUCY2D OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	5.28e-05	542	74	10	IPR011009
Domain	PROTEIN_KINASE_ATP	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 STKLD1 MAP3K21 GRK1	8.11e-05	459	74	9	PS00107
Domain	Ser/Thr_kinase_AS	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 MAP3K21 GRK1	8.28e-05	357	74	8	IPR008271
Domain	S_TKc	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 MAP3K21 GRK1	8.60e-05	359	74	8	SM00220
Domain	PROTEIN_KINASE_ST	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 MAP3K21 GRK1	9.12e-05	362	74	8	PS00108
Domain	Pkinase	TLK2 TLK1 OBSCN MASTL PRKG1 CAMK1 STKLD1 GRK1	1.30e-04	381	74	8	PF00069
Domain	SGNH_hydro	PCED1A SIAE	4.27e-04	8	74	2	IPR013830
Domain	ANK	POTEB3 POTEM POTEG POTED POTEI POTEC	4.79e-04	251	74	6	SM00248
Domain	ANK_REPEAT	POTEB3 POTEM POTEG POTED POTEI POTEC	5.00e-04	253	74	6	PS50088
Domain	ANK_REP_REGION	POTEB3 POTEM POTEG POTED POTEI POTEC	5.10e-04	254	74	6	PS50297
Domain	Ankyrin_rpt	POTEB3 POTEM POTEG POTED POTEI POTEC	6.00e-04	262	74	6	IPR002110
Domain	Protein_kinase_ATP_BS	TLK2 TLK1 OBSCN PRKG1 CAMK1 MAP3K21 GRK1	7.51e-04	379	74	7	IPR017441
Domain	AGC-kinase_C	MASTL PRKG1 GRK1	1.42e-03	56	74	3	IPR000961
Domain	AGC_KINASE_CTER	MASTL PRKG1 GRK1	1.42e-03	56	74	3	PS51285
Domain	S_TK_X	MASTL PRKG1 GRK1	1.42e-03	56	74	3	SM00133
Domain	Ank_2	POTEB3 POTEM POTEG POTEI POTEC	1.63e-03	215	74	5	PF12796
Domain	Ank	POTEM POTEG POTED POTEI POTEC	2.11e-03	228	74	5	PF00023
Domain	-	POTEB3 POTEM POTEG POTEI POTEC	3.03e-03	248	74	5	1.25.40.20
Domain	EF-hand_1	ACTN4 ACTN1 ACTN2 ACTN3	3.12e-03	152	74	4	PF00036
Domain	Ankyrin_rpt-contain_dom	POTEB3 POTEM POTEG POTEI POTEC	3.36e-03	254	74	5	IPR020683
Domain	EFh	ACTN4 ACTN1 ACTN2 ACTN3	3.58e-03	158	74	4	SM00054
Domain	CNMP_BINDING_1	KCNH7 PRKG1	7.11e-03	32	74	2	PS00888
Domain	CNMP_BINDING_2	KCNH7 PRKG1	7.11e-03	32	74	2	PS00889
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	ACTN4 ACTN1 ACTN2 ACTN3	9.17e-07	23	47	4	M913
Pathway	BIOCARTA_CELL2CELL_PATHWAY	ACTN1 ACTN2 ACTN3	7.48e-06	12	47	3	M12851
Pathway	BIOCARTA_UCALPAIN_PATHWAY	ACTN1 ACTN2 ACTN3	1.23e-05	14	47	3	M13143
Pathway	KEGG_ADHERENS_JUNCTION	ACTN4 ACTN1 ACTN2 ACTN3	9.97e-05	73	47	4	M638
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	ACTN4 ACTN1 ACTN2 ACTN3	1.05e-04	74	47	4	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	ACTN4 ACTN1 ACTN2 ACTN3	1.05e-04	74	47	4	M16376
Pathway	BIOCARTA_INTEGRIN_PATHWAY	ACTN1 ACTN2 ACTN3	1.93e-04	34	47	3	M3342
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	ACTN4 ACTN2 ACTN3	2.70e-04	38	47	3	M39549
Pathway	BIOCARTA_CELL2CELL_PATHWAY	ACTN2 ACTN3	3.86e-04	9	47	2	MM1366
Pathway	KEGG_FOCAL_ADHESION	LAMA5 ACTN4 ACTN1 ACTN2 ACTN3	5.05e-04	199	47	5	M7253
Pathway	KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	ACTN4 ACTN1 ACTN2 ACTN3	5.91e-04	116	47	4	M2164
Pathway	BIOCARTA_UCALPAIN_PATHWAY	ACTN2 ACTN3	7.03e-04	12	47	2	MM1525
Pathway	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2	TOR4A ACTN4 ACTN1 ACTN2	9.06e-04	130	47	4	MM15455
Pathway	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2	TOR4A ACTN4 ACTN1 ACTN2	9.59e-04	132	47	4	M724
Pathway	KEGG_TIGHT_JUNCTION	ACTN4 ACTN1 ACTN2 ACTN3	9.59e-04	132	47	4	M11355
Pathway	KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS	ACTN4 ACTN1 ACTN2 ACTN3	1.16e-03	139	47	4	M4741
Pubmed	Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.	ACTN4 ACTN1 ACTN2 ACTN3	2.22e-11	4	77	4	16807302
Pubmed	Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.	ACTN4 ACTN1 ACTN2 ACTN3	2.22e-11	4	77	4	1629252
Pubmed	Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.	ACTN4 ACTN1 ACTN2 PRKG1 ACTN3	3.65e-11	12	77	5	15465019
Pubmed	The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.	ACTN4 ACTN1 ACTN2 ACTN3	1.11e-10	5	77	4	12837758
Pubmed	Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.	ACTN4 ACTN1 ACTN2 ACTN3	1.11e-10	5	77	4	19943616
Pubmed	Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.	ACTN4 ACTN1 ACTN2 ACTN3	1.11e-10	5	77	4	15841212
Pubmed	Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.	ACTN4 ACTN1 ACTN2 ACTN3	3.32e-10	6	77	4	18425115
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ACTN4 ACTN1 ACTN2 ACTN3	3.32e-10	6	77	4	22693585
Pubmed	CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.	ACTN4 ACTN1 ACTN2 ACTN3	1.54e-09	8	77	4	20215401
Pubmed	Mice deficient in alpha-actinin-4 have severe glomerular disease.	ACTN4 ACTN1 ACTN2 ACTN3	1.54e-09	8	77	4	12782671
Pubmed	Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.	ACTN4 ACTN1 ACTN2 ACTN3	4.62e-09	10	77	4	20368620
Pubmed	α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.	ACTN4 ACTN1 ACTN3	1.04e-08	3	77	3	21784188
Pubmed	Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.	ACTN4 ACTN2 ACTN3	1.04e-08	3	77	3	8104223
Pubmed	The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.	ACTN4 ACTN2 ACTN3	1.04e-08	3	77	3	10656685
Pubmed	Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.	ACTN4 ACTN1 ACTN2 ACTN3	2.98e-08	15	77	4	11440986
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEM POTEG POTEC	2.08e-07	6	77	3	17171436
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEB3 POTEG POTED	3.63e-07	7	77	3	15276201
Pubmed	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	ACTN4 ACTN1 ACTN2	3.63e-07	7	77	3	11724819
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	ACTN4 ACTN1 ACTN2 ACTN3	3.75e-07	27	77	4	36899856
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB3 POTED POTEC	5.80e-07	8	77	3	12475935
Pubmed	The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.	ACTN2 CDC73 ACTN3	5.80e-07	8	77	3	18687124
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTEM POTED POTEI	8.68e-07	9	77	3	16364570
Pubmed	Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.	ACTN1 ACTN2 ACTN3	8.68e-07	9	77	3	11114196
Pubmed	A human MAP kinase interactome.	EHBP1 TLK1 SIMC1 ACTN4 ACTN1 CPLANE1 MAP3K21 HERPUD1 ENKD1	1.31e-06	486	77	9	20936779
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	PCED1A NLGN3 LRSAM1 LAMA5 FRYL ACTN1 ACTN2 CPLANE1 TRIM27	4.16e-06	560	77	9	21653829
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEM POTEG POTEI	4.66e-06	15	77	3	16824795
Pubmed	α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.	ACTN4 ACTN1	4.84e-06	2	77	2	23454549
Pubmed	α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.	ACTN2 ACTN3	4.84e-06	2	77	2	22253474
Pubmed	alpha-actinin-3 and performance.	ACTN2 ACTN3	4.84e-06	2	77	2	19696509
Pubmed	The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.	TLK2 TLK1	4.84e-06	2	77	2	21647934
Pubmed	Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking.	ACTN4 ACTN1	4.84e-06	2	77	2	34010028
Pubmed	Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo.	ACTN2 ACTN3	4.84e-06	2	77	2	9675099
Pubmed	Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells.	ACTN4 ACTN1	4.84e-06	2	77	2	20156433
Pubmed	An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle α-actinins.	ACTN4 ACTN1	4.84e-06	2	77	2	23557398
Pubmed	Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.	ACTN1 ACTN2	4.84e-06	2	77	2	23664615
Pubmed	Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes.	ACTN2 ACTN3	4.84e-06	2	77	2	32451822
Pubmed	Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.	ACTN2 ACTN3	4.84e-06	2	77	2	1339456
Pubmed	Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.	ACTN2 ACTN3	4.84e-06	2	77	2	19150855
Pubmed	Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.	TLK2 TLK1	4.84e-06	2	77	2	32755577
Pubmed	Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology.	ACTN4 ACTN1	4.84e-06	2	77	2	20037648
Pubmed	cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.	TLK2 TLK1	4.84e-06	2	77	2	9427565
Pubmed	HAMLET binding to α-actinin facilitates tumor cell detachment.	ACTN4 ACTN1	4.84e-06	2	77	2	21408150
Pubmed	Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells.	ACTN4 ACTN1	4.84e-06	2	77	2	28797528
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	LRSAM1 ACTN4 ACTN1 ACTN2 TRIM27	6.71e-06	118	77	5	21078624
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	SIAE OGT OBSCN LAMA5 ACTN1 DOP1B	8.34e-06	214	77	6	22199357
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	EHBP1 ACACB TCOF1 JRK OBSCN TOR4A	1.14e-05	226	77	6	31452512
Pubmed	Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment.	ACTN4 ACTN2	1.45e-05	3	77	2	21940706
Pubmed	Direct binding of alpha-actinin enhances TRPP3 channel activity.	ACTN1 ACTN2	1.45e-05	3	77	2	17944866
Pubmed	Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.	ACTN1 ACTN2	1.45e-05	3	77	2	30768638
Pubmed	Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.	TLK2 TLK1	1.45e-05	3	77	2	28535374
Pubmed	Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin.	ACTN4 ACTN1	1.45e-05	3	77	2	16751418
Pubmed	The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism.	ACTN1 ACTN2	1.45e-05	3	77	2	11101506
Pubmed	Interaction of PKN with alpha-actinin.	ACTN1 ACTN2	1.45e-05	3	77	2	9030526
Pubmed	Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.	ACTN4 ACTN1	1.45e-05	3	77	2	23890175
Pubmed	Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis.	ACTN4 ACTN1	1.45e-05	3	77	2	16951376
Pubmed	The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.	TLK2 TLK1	1.45e-05	3	77	2	38498025
Pubmed	Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.	ACTN4 ACTN1	2.89e-05	4	77	2	22351778
Pubmed	CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.	ACTN4 ACTN1	2.89e-05	4	77	2	10753915
Pubmed	Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.	TLK2 TLK1	2.89e-05	4	77	2	11470414
Pubmed	Titin mutations as the molecular basis for dilated cardiomyopathy.	ACTN1 ACTN2	2.89e-05	4	77	2	11846417
Pubmed	ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.	ACTN1 ACTN2	2.89e-05	4	77	2	12446711
Pubmed	Interactions of a hemidesmosome component and actinin family members.	ACTN4 ACTN1	2.89e-05	4	77	2	11739652
Pubmed	Structure and chromosomal localization of mouse G protein subunit gamma 4 gene.	LAMA5 TRIM27	2.89e-05	4	77	2	9570961
Pubmed	Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.	TLK2 TLK1	2.89e-05	4	77	2	10523312
Pubmed	Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation.	ACTN4 ACTN1	2.89e-05	4	77	2	23515331
Pubmed	Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.	ACTN1 ACTN2	2.89e-05	4	77	2	9501083
Pubmed	Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.	TLK2 TLK1	2.89e-05	4	77	2	20016786
Pubmed	Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis.	POTEM POTEC	2.89e-05	4	77	2	17342726
Pubmed	An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.	ACTN4 ACTN1	2.89e-05	4	77	2	2116421
Pubmed	Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors.	ACTN4 ACTN2	2.89e-05	4	77	2	16510730
Pubmed	Structural dynamics of alpha-actinin-vinculin interactions.	ACTN4 ACTN1	2.89e-05	4	77	2	15988023
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	POTEB3 POTEM POTEG POTEI POTEC	3.20e-05	163	77	5	24316575
Pubmed	Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.	ACTN4 ACTN1 ACTN2	4.49e-05	31	77	3	14630798
Pubmed	Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.	ACTN2 ACTN3	4.82e-05	5	77	2	11171996
Pubmed	Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.	ACTN2 ACTN3	4.82e-05	5	77	2	9268580
Pubmed	Tousled-like kinase in a microbial eukaryote regulates spindle assembly and S-phase progression by interacting with Aurora kinase and chromatin assembly factors.	TLK2 TLK1	4.82e-05	5	77	2	17940067
Pubmed	Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.	ACTN1 ACTN2	4.82e-05	5	77	2	15665106
Pubmed	The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte.	ACTN4 ACTN1	4.82e-05	5	77	2	16501493
Pubmed	cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.	GUCY2D PRKG1	4.82e-05	5	77	2	26124274
Pubmed	Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.	ACTN2 ACTN3	4.82e-05	5	77	2	21536590
Pubmed	p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.	ACTN2 ACTN3	4.82e-05	5	77	2	9438383
Pubmed	The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin.	ACTN4 ACTN1	7.22e-05	6	77	2	15070900
Pubmed	Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.	TLK2 TLK1	7.22e-05	6	77	2	12660173
Pubmed	Temporal and spatial expression pattern of beta1 sodium channel subunit during heart development.	ACTN1 ACTN2	1.01e-04	7	77	2	15721864
Pubmed	An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.	ACTN1 ACTN2	1.01e-04	7	77	2	31573406
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	SLC4A10 LAMA5 BCAT2	1.29e-04	44	77	3	27534441
Pubmed	Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.	ACTN2 ACTN3	1.34e-04	8	77	2	11309420
Pubmed	The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.	ACTN2 ACTN3	1.34e-04	8	77	2	11381084
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TLK2 NLGN3 SIAE OGT OBSCN MASTL ACTN4 FRYL CPLANE1 ARHGAP21	1.37e-04	1084	77	10	11544199
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	ACTN4 ACTN1 ACTN3	1.38e-04	45	77	3	22114352
Pubmed	Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype.	ERG TFAP2A	1.72e-04	9	77	2	34615475
Pubmed	RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.	ACTN4 POTEI TRIM27	1.90e-04	50	77	3	30413534
Pubmed	The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation.	ERG ACTN2	2.15e-04	10	77	2	37787076
Pubmed	Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.	ACTN1 ACTN2	2.63e-04	11	77	2	11842093
Pubmed	Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.	ACTN2 ACTN3	2.63e-04	11	77	2	16585392
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	TLK2 MASTL	3.15e-04	12	77	2	27782176
Pubmed	BAF200 is required for heart morphogenesis and coronary artery development.	ACTN2 TFAP2A	3.15e-04	12	77	2	25299188
Pubmed	Molecular diversity of myofibrillar proteins: gene regulation and functional significance.	ACTN2 ACTN3	3.15e-04	12	77	2	8618961
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EHBP1 ZNF536 OGT ACACB FIZ1 ARHGAP21	3.36e-04	418	77	6	34709266
Pubmed	High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.	OGT TFAP2A	3.71e-04	13	77	2	17670746
Interaction	POTEC interactions	POTEB3 POTEG POTED POTEC	1.37e-07	13	77	4	int:POTEC
Interaction	POTED interactions	POTEB3 POTED POTEC	2.14e-07	4	77	3	int:POTED
Interaction	MYOZ2 interactions	ACTN4 ACTN1 ACTN2 ACTN3	1.37e-06	22	77	4	int:MYOZ2
Interaction	ADORA2A interactions	ACTN4 ACTN1 ACTN2 ACTN3	3.23e-06	27	77	4	int:ADORA2A
Interaction	SYNPO2L interactions	ACTN1 ACTN2 ACTN3	8.66e-06	11	77	3	int:SYNPO2L
Interaction	POTEB3 interactions	POTEB3 POTED TRIM27 POTEC	9.43e-06	35	77	4	int:POTEB3
Interaction	MYOZ1 interactions	ACTN4 ACTN1 ACTN2 ACTN3	3.10e-05	47	77	4	int:MYOZ1
Interaction	RGS9 interactions	GUCY2D ACTN4 ACTN2	4.97e-05	19	77	3	int:RGS9
Interaction	MYH2 interactions	OBSCN ACTN4 ACTN1 ACTN2	5.00e-05	53	77	4	int:MYH2
Interaction	ATXN7 interactions	LRSAM1 ACTN4 ACTN1 ACTN2 TRIM27	6.12e-05	109	77	5	int:ATXN7
Interaction	ACTN3 interactions	ACTN4 ACTN1 ACTN2 CDC73 ACTN3	6.12e-05	109	77	5	int:ACTN3
Interaction	MYH15 interactions	ACTN4 ACTN1 ACTN3	6.79e-05	21	77	3	int:MYH15
Interaction	MYOT interactions	ACTN1 ACTN2 ACTN3	6.79e-05	21	77	3	int:MYOT
Interaction	CAMK2A interactions	RPUSD4 OGT ACTN4 ACTN1 ACTN2 TRIM27 GABBR1	9.51e-05	279	77	7	int:CAMK2A
GeneFamily	Actinins	ACTN4 ACTN1 ACTN2 ACTN3	2.51e-11	4	42	4	1112
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEM POTEG POTED POTEI POTEC	6.71e-11	13	42	5	685
GeneFamily	Ankyrin repeat domain containing	POTEM POTEG POTED POTEI POTEC	2.34e-04	242	42	5	403
GeneFamily	Clustered protocadherins	PCDHGB2 PCDHA1	9.70e-03	64	42	2	20
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN1 ACTN2 ACTN3	1.54e-10	5	71	4	DOID:0111128 (implicated_via_orthology)
Disease	migraine disorder, type 2 diabetes mellitus	SLC4A10 FRYL ACTN1	4.14e-04	60	71	3	MONDO_0005148, MONDO_0005277
Disease	cleft lip	EHBP1 ZNF536 GVINP1 NUP210L PRKG1	6.18e-04	284	71	5	EFO_0003959
Disease	alkaline phosphatase measurement	RPUSD4 TLK1 ACACB UCKL1 BCAT2 PGAP4 STKLD1 ARHGAP21 GABBR1	7.16e-04	1015	71	9	EFO_0004533
Disease	periodontitis	GVINP1 FIZ1 ACTN1 ACTN2	2.08e-03	223	71	4	EFO_0000649
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	EHBP1 ACACB BCAT2 HERPUD1	2.14e-03	225	71	4	EFO_0008317, EFO_0010351
Disease	coronary artery disease	EHBP1 SLC9A8 KCNH7 ERG PRKG1 HERPUD1 ARHGAP21 ELL GABBR1	2.21e-03	1194	71	9	EFO_0001645
Disease	mammographic density percentage	GVINP1 PRKG1	2.22e-03	29	71	2	EFO_0006502
Disease	remnant cholesterol measurement	EHBP1 BCAT2 HERPUD1	2.27e-03	108	71	3	EFO_0010815

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKGHVPHYLLERRDL	ENKD1	241	Q9H0I2
VLHLLALRPYRKAEL	ELL	211	P55199
ALIHRHRPELIDYGK	ACTN1	181	P12814
LCALIHRHRPDLIDY	ACTN2	186	P35609
VLELSYHKRHLDRPV	CDC73	496	Q6P1J9
DILLSHLHYLRETPL	ERG	186	P11308
KSHLRSLLDPHIYRV	GVINP1	591	Q7Z2Y8
YLHRHGIIHRDLKPD	MASTL	146	Q96GX5
LIHRHRPELIEYDKL	ACTN4	201	O43707
LDPRRDYRRHEDLLH	TFAP2A	121	P05549
ELRLPHYLRSKALEL	FAM186B	681	Q8IYM0
VPLLAEYRHLRKLQD	CCDC22	426	O60826
HLKAHLSRVYPERPR	HERPUD1	36	Q15011
VPLHRLKDIRLLYGE	ACACB	611	O00763
HRIYLQPGRLAKHLE	ITIH2	196	P19823
LLLDLIKGIRYLHHR	GUCY2D	646	Q02846
YLPIFAHHRLSLDLL	LRSAM1	586	Q6UWE0
SLELHLRQRKTYVHP	KCNH7	1151	Q9NS40
SRRDILPDYELKLIH	GABBR1	201	Q9UBS5
IYRDLKPENLILDHR	PRKG1	481	Q13976
RHHAYLKPFRVLISL	DOP1B	356	Q9Y3R5
LHTPKLEHLDRVLYE	JRK	81	O75564
YPELILKHSLDREEH	PCDHGB2	191	Q9Y5G2
HSERLIHTYKLDRRP	PCED1A	431	Q9H1Q7
PEVYEHCKRLLLHLL	FRYL	1636	O94915
RFSEPHLRDALYLKL	PGAP4	231	Q9BRR3
HLRDALYLKLYHPER	PGAP4	236	Q9BRR3
HYLPDLHHLRLELEE	LAMA5	866	O15230
LYHHAEPLAAVLRLR	PLEKHM3	591	Q6ZWE6
LRKYLDREETPELHL	PCDHA1	196	Q9Y5I3
YLHDLGIVHRDLKPE	CAMK1	131	Q14012
PRYHVRREDLDKLHR	POTEB3	131	A0JP26
LHAAYLSPRHLVLIL	OBSCN	7731	Q5VST9
RRKDQFLHPIDLHLL	MON1A	431	Q86VX9
QLYLHIGLKPRVRDH	NLGN3	601	Q9NZ94
RVPLRDKYHSLHQRL	CPLANE1	1376	Q9H799
LHRELPLHLNKRYGA	GALNT8	41	Q9NY28
RIAHLERHHKPYALD	GALNT8	406	Q9NY28
LHVLVERHLPLEYRQ	CENPT	531	Q96BT3
PLLYLLVRKHINRAH	GPR157	186	Q5UAW9
RHHLPEEYLEKRLSK	ASCL3	116	Q9NQ33
PLTELDIHHRILRYT	ATG9B	351	Q674R7
ILHHFRPDLIDYKSL	EHBP1	481	Q8NDI1
YLKRHRLLHGTERPF	FIZ1	456	Q96SL8
AALRKLLHAEPERYR	HELZ2	1116	Q9BYK8
EHLHQRRIVYRDLKP	GRK1	306	Q15835
PVHRILYKDRNLHIP	BCAT2	346	O15382
IPKDEHILRFLRAHD	SEC14L5	261	O43304
KFPLEHYILELQDHR	NUP210L	286	Q5VU65
QEAIEHYRHALRLKP	OGT	106	O15294
PRYHVRREDLDKLHR	POTEC	131	B2RU33
PRYHIRREDLDKLHR	POTED	131	Q86YR6
EQSKARYIPLHLHAR	RPUSD4	311	Q96CM3
DYREKLLHLRKLRHD	UTP20	691	O75691
HSLKEHEYRLLARLE	TRIM27	191	P14373
KRRELLPLIYHHLLR	TCOF1	6	Q13428
LHEEAFVPILHRDLK	MAP3K21	251	Q5TCX8
RIKHDALSIYHILPE	NSUN7	176	Q8NE18
LHRLKYFLRPPVHHL	SIMC1	431	Q8NDZ2
IHPRDKQTVAYRLHL	SIAE	376	Q9HAT2
VHLLIRYRLHFLPES	SLC9A8	76	Q9Y2E8
PRYHVRREDLDKLHR	POTEI	131	P0CG38
RIHKELDHPRIVKLY	TLK2	516	Q86UE8
LIHRHRPDLIDYAKL	ACTN3	196	Q08043
PRLHRRHRVYKLVED	MRPL9	71	Q9BYD2
YRKELHDLFNLPHDR	UFSP2	226	Q9NUQ7
CREYRIHKELDHPRI	TLK1	506	Q9UKI8
HLRERDSKLYLHELL	TMEM199	66	Q8N511
EYLHHLDIIHRNLKP	STKLD1	146	Q8NE28
DFIYLRHVPLRKVHL	SLC4A10	971	Q6U841
NPLHLSRERYRKLHL	UBR1	1706	Q8IWV7
HRLDYIPHQLELKFE	SAXO2	151	Q658L1
REELDRHIRILHKPY	ZNF536	286	O15090
RDYLATHVHSRPLLL	TOR4A	176	Q9NXH8
HYLRLPKDISDDHVI	UCKL1	436	Q9NWZ5
RLIHDLPEHHYETLK	ARHGAP21	1261	Q5T5U3
PRYHVRREDLDKLHR	POTEG	131	Q6S5H5
PRYHVRREDLDKLHR	POTEM	131	A6NI47
ASELRRLYRHIHPEL	XIRP1	51	Q702N8
RLYRHIHPELRKNLA	XIRP1	56	Q702N8