Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH10 DNAH5 DYNC1H1

7.42e-0618433GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH10 DNAH5 DYNC1H1

2.93e-0528433GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH10 DNAH5 DYNC1H1

6.87e-0537433GO:0045505
GeneOntologyMolecularFunctionATP-dependent activity

SMARCA1 SMARCA5 POLQ DNAH10 DNAH5 DYNC1H1 SMC1B

3.09e-04614437GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

SMARCA5 POLQ DNAH10 DNAH5 DYNC1H1 SMC1B

3.42e-04441436GO:0016887
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH10 DNAH5 DYNC1H1

4.60e-0470433GO:0003777
GeneOntologyMolecularFunctionmonosaccharide binding

SIGLEC14 SIGLEC5 P4HTM

1.12e-0395433GO:0048029
GeneOntologyMolecularFunctionsialic acid binding

SIGLEC14 SIGLEC5

1.32e-0325432GO:0033691
GeneOntologyMolecularFunctionDNA-directed DNA polymerase activity

POLQ PRIMPOL

1.32e-0325432GO:0003887
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH10 DNAH5 DYNC1H1

2.09e-03118433GO:0003774
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

SMARCA1 SMARCA5 POLQ PRIMPOL

2.39e-03262434GO:0140097
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SMARCA1 SMARCA5 POLQ

2.58e-03127433GO:0008094
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SMARCA1 SMARCA5

2.88e-0337432GO:0140658
GeneOntologyMolecularFunctionDNA polymerase activity

POLQ PRIMPOL

3.03e-0338432GO:0034061
GeneOntologyMolecularFunctionhelicase activity

SMARCA1 SMARCA5 POLQ

4.76e-03158433GO:0004386
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

SMARCA5 POLQ DNAH10 DNAH5 DYNC1H1 SMC1B

6.00e-03775436GO:0017111
GeneOntologyCellularComponentNURF complex

SMARCA1 SMARCA5

8.62e-057432GO:0016589
GeneOntologyCellularComponentdynein complex

DNAH10 DNAH5 DYNC1H1

1.87e-0454433GO:0030286
GeneOntologyCellularComponentISWI-type complex

SMARCA1 SMARCA5

3.70e-0414432GO:0031010
MousePhenoabnormal eosinophil differentiation

SIGLEC14 SIGLEC5

4.08e-054372MP:0002443
DomainDynein_heavy_dom-1

DNAH10 DNAH5 DYNC1H1

6.78e-078443IPR013594
DomainDHC_N1

DNAH10 DNAH5 DYNC1H1

6.78e-078443PF08385
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH5 DYNC1H1

4.36e-0614443IPR011704
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH5 DYNC1H1

4.36e-0614443IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH5 DYNC1H1

4.36e-0614443IPR024743
DomainDynein_heavy_dom-2

DNAH10 DNAH5 DYNC1H1

4.36e-0614443IPR013602
DomainDHC_N2

DNAH10 DNAH5 DYNC1H1

4.36e-0614443PF08393
DomainMT

DNAH10 DNAH5 DYNC1H1

4.36e-0614443PF12777
DomainAAA_8

DNAH10 DNAH5 DYNC1H1

4.36e-0614443PF12780
DomainAAA_5

DNAH10 DNAH5 DYNC1H1

4.36e-0614443PF07728
DomainSLIDE

SMARCA1 SMARCA5

5.42e-062442IPR015195
DomainISWI_HAND-dom

SMARCA1 SMARCA5

5.42e-062442IPR015194
DomainSLIDE

SMARCA1 SMARCA5

5.42e-062442PF09111
DomainHAND

SMARCA1 SMARCA5

5.42e-062442PF09110
DomainISWI

SMARCA1 SMARCA5

5.42e-062442IPR029915
DomainDHC_fam

DNAH10 DNAH5 DYNC1H1

5.44e-0615443IPR026983
DomainDynein_heavy_dom

DNAH10 DNAH5 DYNC1H1

5.44e-0615443IPR004273
DomainDynein_heavy

DNAH10 DNAH5 DYNC1H1

5.44e-0615443PF03028
DomainDBINO

SMARCA1 SMARCA5

1.62e-053442IPR020838
DomainDBINO

SMARCA1 SMARCA5

1.62e-053442PF13892
Domain-

SMARCA1 NLRP12 SMARCA5 POLQ DNAH10 DNAH5 AK7 DYNC1H1 SMC1B

4.97e-057464493.40.50.300
DomainP-loop_NTPase

SMARCA1 NLRP12 SMARCA5 POLQ DNAH10 DNAH5 AK7 DYNC1H1 SMC1B

1.33e-04848449IPR027417
DomainSANT_dom

SMARCA1 SMARCA5

1.70e-0326442IPR017884
DomainSANT

SMARCA1 SMARCA5

1.97e-0328442PS51293
DomainHelicase_C

SMARCA1 SMARCA5 POLQ

2.04e-03107443PF00271
DomainHELICc

SMARCA1 SMARCA5 POLQ

2.04e-03107443SM00490
DomainHelicase_C

SMARCA1 SMARCA5 POLQ

2.10e-03108443IPR001650
DomainHELICASE_CTER

SMARCA1 SMARCA5 POLQ

2.15e-03109443PS51194
DomainHELICASE_ATP_BIND_1

SMARCA1 SMARCA5 POLQ

2.15e-03109443PS51192
DomainDEXDc

SMARCA1 SMARCA5 POLQ

2.15e-03109443SM00487
DomainHelicase_ATP-bd

SMARCA1 SMARCA5 POLQ

2.21e-03110443IPR014001
DomainSNF2_N

SMARCA1 SMARCA5

2.57e-0332442PF00176
DomainSNF2_N

SMARCA1 SMARCA5

2.57e-0332442IPR000330
DomainDEAH_ATP_HELICASE

SMARCA1 SMARCA5

3.61e-0338442PS00690
DomainAAA+_ATPase

DNAH10 DNAH5 DYNC1H1

4.72e-03144443IPR003593
DomainAAA

DNAH10 DNAH5 DYNC1H1

4.72e-03144443SM00382
DomainSANT

SMARCA1 SMARCA5

6.18e-0350442SM00717
DomainSANT/Myb

SMARCA1 SMARCA5

6.67e-0352442IPR001005
DomainIg/MHC_CS

SIGLEC14 SIGLEC5

8.25e-0358442IPR003006
DomainIG_MHC

SIGLEC14 SIGLEC5

8.80e-0360442PS00290
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH10 DNAH5 DYNC1H1

6.81e-07144439373155
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SMARCA1 GEMIN4 SMARCA5 PRPF8 ADNP DNAH10 OGDH DNAH5 HACD3 DYNC1H1 HNRNPR

1.16e-061425441130948266
Pubmed

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

SIGLEC14 SIGLEC5

1.56e-06244224799499
Pubmed

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

SIGLEC14 SIGLEC5

1.56e-06244226459514
Pubmed

Binding kinetics of human ISWI chromatin-remodelers to DNA repair sites elucidate their target location mechanism.

SMARCA1 SMARCA5

4.69e-06344221738833
Pubmed

Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.

SIGLEC14 SIGLEC5

4.69e-06344224698729
Pubmed

Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l.

SMARCA1 SMARCA5

4.69e-06344211359880
Pubmed

Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.

SIGLEC14 SIGLEC5

4.69e-06344211579105
Pubmed

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

SIGLEC14 SIGLEC5

4.69e-06344217012248
Pubmed

Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.

SIGLEC14 SIGLEC5

4.69e-06344231520477
Pubmed

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.

SIGLEC14 SIGLEC5

4.69e-06344223710953
Pubmed

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.

SIGLEC14 SIGLEC5

4.69e-06344219783675
Pubmed

Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.

SIGLEC14 SIGLEC5

4.69e-06344230577572
Pubmed

A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.

SIGLEC14 SIGLEC5

4.69e-06344232247614
Pubmed

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.

SIGLEC14 SIGLEC5

4.69e-06344232134149
Pubmed

NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression.

NLRP12 IFNAR1

4.69e-06344236719379
Pubmed

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.

SIGLEC14 SIGLEC5

4.69e-06344225497369
Pubmed

Siglec-F is a novel intestinal M cell marker.

SIGLEC14 SIGLEC5

4.69e-06344227524237
Pubmed

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.

SIGLEC14 SIGLEC5

9.37e-06444217562860
Pubmed

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

SIGLEC14 SIGLEC5

9.37e-06444217272508
Pubmed

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.

SIGLEC14 SIGLEC5

9.37e-06444219178537
Pubmed

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.

SIGLEC14 SIGLEC5

9.37e-06444233289969
Pubmed

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.

SIGLEC14 SIGLEC5

9.37e-06444237251384
Pubmed

The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.

UNC13B RAB3GAP1

9.37e-06444214593078
Pubmed

IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils.

SIGLEC14 SIGLEC5

9.37e-06444233976385
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SMARCA5 PRPF8 OGDH DNAH5 HNRNPR

1.16e-0523444536243803
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

GEMIN4 DIP2A MRPL40 RAB3GAP1 HM13 RMDN2 OGDH HACD3 PRAME HNRNPR

1.37e-051496441032877691
Pubmed

Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.

SIGLEC14 SIGLEC5

1.56e-05544220395633
Pubmed

Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.

SIGLEC14 SIGLEC5

1.56e-05544221040544
Pubmed

Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.

SIGLEC14 SIGLEC5

1.56e-05544235482420
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

GEMIN4 P4HTM HM13 PRPF8 HACD3 HERC4 PRAME MFSD10 HNRNPR

1.64e-05120344929180619
Pubmed

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

SMARCA1 SMARCA5 ADNP HNRNPR

1.87e-0512444420850016
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

SMARCA1 SMARCA5 PRPF8

2.25e-054344326030138
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

SMARCA5 PRPF8 ADNP HNRNPR

2.32e-0513144434551306
Pubmed

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.

SIGLEC14 SIGLEC5

2.34e-05644223880769
Pubmed

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).

SIGLEC14 SIGLEC5

2.34e-05644214559209
Pubmed

WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

SMARCA1 SMARCA5

2.34e-05644211980720
Pubmed

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

PRPF8 OGDH HACD3 DYNC1H1 HNRNPR

2.79e-0528144526725010
Pubmed

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].

SIGLEC14 SIGLEC5

3.27e-05744218453149
Pubmed

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

SIGLEC14 SIGLEC5

3.27e-05744223677475
Pubmed

The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.

SIGLEC14 SIGLEC5

3.27e-05744215048729
Pubmed

Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.

SIGLEC14 SIGLEC5

3.27e-05744223840825
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

GEMIN4 SMARCA5 PRPF8 SACS HACD3 HNRNPR

3.72e-0549844636634849
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SMARCA1 GEMIN4 RAB3GAP1 SMARCA5 PRPF8 ADNP HACD3 DYNC1H1 HNRNPR

4.12e-05135344929467282
Pubmed

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

SMARCA1 SMARCA5

5.60e-05944216728976
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

MRPL40 SMARCA5 PRPF8 ADNP SACS OGDH DYNC1H1 HNRNPR

5.60e-05108244838697112
Pubmed

Human transcription factor protein interaction networks.

SMARCA1 NFYC SMARCA5 ADNP DNAH10 HACD3 DYNC1H1 HNRNPR NFRKB

6.28e-05142944935140242
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DIP2A UGGT2 MRPL40 RAB3GAP1 HM13 PRPF8 SACS OGDH HACD3

8.52e-05148744933957083
Pubmed

Selective Response to Bacterial Infection by Regulating Siglec-E Expression.

SIGLEC14 SIGLEC5

8.54e-051144232889432
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

SMARCA1 SMARCA5 PRPF8 HACD3

9.48e-0518844429721183
Pubmed

The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation.

GEMIN4 HNRNPR

1.02e-041244216236758
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SMARCA1 GEMIN4 SMARCA5 PRPF8 ADNP HNRNPR

1.09e-0460544628977666
Pubmed

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.

SIGLEC14 SIGLEC5

1.21e-041344235921817
Pubmed

The NLRP12 inflammasome recognizes Yersinia pestis.

NLRP12 IFNAR1

1.41e-041444222840842
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

GEMIN4 SMARCA5 PRPF8 HACD3 DYNC1H1 HNRNPR

1.45e-0463844633239621
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

SMARCA1 GEMIN4 SMARCA5 PRPF8 ADNP HACD3 DYNC1H1 HNRNPR

1.58e-04125744836526897
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

SMARCA5 PRPF8 ADNP HACD3 SMC1B HNRNPR

1.63e-0465244631180492
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

SMARCA5 PRPF8 ADNP HNRNPR

1.73e-0422044435785414
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

SMARCA1 NFYC SMARCA5 PRPF8 OGDH HNRNPR

1.75e-0466044632780723
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

SMARCA1 SMARCA5 PRPF8 OGDH HERC4 DYNC1H1

1.82e-0466544630457570
Pubmed

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

SMARCA5 PRPF8

1.86e-041644228803780
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

MRPL40 HM13 PRPF8 OGDH DYNC1H1

1.89e-0442244527342126
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

UGGT2 MRPL40 P4HTM HM13 PIR PRPF8 HERC4 DYNC1H1

1.96e-04129744833545068
Pubmed

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

SIGLEC14 SIGLEC5

2.10e-041744235709757
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

NFYC SMARCA5 NFRKB

2.12e-049144320362542
Pubmed

USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.

SMARCA1 SMARCA5

2.36e-041844217846119
Pubmed

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

NFYC GEMIN4

2.36e-041844219047128
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

SMARCA1 RAB3GAP1 SMARCA5 PRPF8 DNAH5 DYNC1H1

2.47e-0470444629955894
Pubmed

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.

SMARCA1 SMARCA5

2.64e-041944227246713
Pubmed

Global landscape of HIV-human protein complexes.

GEMIN4 PTK2B HM13 HACD3 DYNC1H1

2.73e-0445744522190034
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

SMARCA5 PRPF8 ADNP SACS HACD3 DYNC1H1 HNRNPR

2.78e-04102444724711643
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

UNC13B SMARCA1 GEMIN4 SMARCA5 HM13 PRPF8 HACD3 DYNC1H1

2.86e-04137144836244648
Pubmed

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.

SMARCA5 PRPF8 HACD3 DYNC1H1 HNRNPR

2.90e-0446344534901782
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

SMARCA1 SMARCA5 ADNP

3.06e-0410344332744500
Pubmed

Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.

SMARCA1 SMARCA5

3.24e-042144231680852
Pubmed

CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.

SMARCA1 SMARCA5

3.24e-042144222154806
Pubmed

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

GEMIN4 PRPF8 PRAME

3.81e-0411144332683582
Pubmed

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

GEMIN4 PRPF8

3.89e-042344220696395
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SMARCA1 UGGT2 SMARCA5 POLQ PRPF8 SACS OGDH HNRNPR

4.01e-04144244835575683
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

PRPF8 DYNC1H1

4.24e-042444233705438
Pubmed

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

SIGLEC14 SIGLEC5

4.24e-042444215331780
Pubmed

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.

SMARCA1 SMARCA5

4.24e-042444224946904
Pubmed

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

PRPF8 OGDH HACD3 DYNC1H1

4.39e-0428144430455355
Pubmed

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.

HM13 HACD3 HERC4 MFSD10

4.45e-0428244435007762
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

GEMIN4 PRPF8 OGDH HACD3 DYNC1H1 HNRNPR

5.17e-0480944632129710
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

SMARCA1 SMARCA5 ADNP DYNC1H1 NFRKB

5.50e-0453344530554943
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

MRPL40 SMARCA5 POLQ PRPF8 AK7 DYNC1H1 HNRNPR

5.67e-04115344729845934
Pubmed

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.

SMARCA5 ADNP DYNC1H1

5.78e-0412844323858473
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

NLRP12 PRAME

5.79e-042844225089626
Pubmed

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.

MRPL40 TSSK1B

5.79e-042844210963672
Pubmed

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.

SIGLEC14 SIGLEC5

6.21e-042944233567267
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

SMARCA1 NFYC SMARCA5 PRPF8 ADNP DYNC1H1

6.99e-0485744625609649
Pubmed

Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome.

MRPL40 SMARCA5

7.11e-043144215778864
Pubmed

Proteomic analysis of complexes formed by human topoisomerase I.

PRPF8 HNRNPR

7.57e-043244215848144
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

SMARCA1 SMARCA5 PRPF8 HNRNPR

8.01e-0433044433301849
Pubmed

High-resolution recombinational map of mouse chromosome 16.

TSSK1B IFNAR1

8.06e-04334429244437
Pubmed

Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.

MRPL40 TSSK1B

8.06e-043344210704284
Pubmed

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

SMARCA1 SMARCA5

8.06e-043344233567268
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

SMARCA5 PRPF8 DYNC1H1

8.13e-0414444335681168
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

GEMIN4 SMARCA5 PRPF8 DYNC1H1 HNRNPR

8.17e-0458244520467437
GeneFamilyDyneins, axonemal

DNAH10 DNAH5

3.10e-0417282536
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC14 SIGLEC5

8.53e-0428282745
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

GEMIN4 PTK2B

2.81e-0351282870
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

SMARCA1 SMARCA5

3.04e-0353282532
GeneFamilyAdenosine receptors|V-set domain containing

SIGLEC14 SIGLEC5

2.62e-02163282590
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_500

SMARCA5 RMDN2 SACS AK7 SMC1B HNRNPR IFNAR1

1.25e-05382447gudmap_developingGonad_e14.5_ ovary_500
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

UNC13B ADGRV1 DNAH5 TSSK1B

3.03e-05181444c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13B DNAH10 DNAH5 AK7

3.90e-05193444bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellControl-Control-Myeloid-immature_Neutrophil|Control / Disease, condition lineage and cell class

UGGT2 SLC8B1 POLQ DNAH10

4.48e-05200444118321ac443feb42aee171baccfc4610f00a8822
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TDRD15 NLRP12 SMC1B

2.15e-04118443c351e465ece4f3767b2c19e695eca3c263c68777
ToppCellControl-Epithelial_alveolar-Mes-Like-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIR DNAH10 AK7

2.67e-04127443556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Intermediate_Fibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

DNAH10 PRAME NFRKB

3.34e-04137443dd5364a1002650d21e0c83d8c701b5f7b09d1c19
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SIGLEC14 PTK2B NLRP12

3.71e-04142443f720f13b339589fa924a42e89393e5db0b26300b
ToppCellLPS-antiTNF-Myeloid-Myeloid_granulocytic|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NLRP12 SLC8B1 SMC1B

3.78e-041434434a0f26eef935fe68a1da5d319503059a8a8682dd
ToppCellLPS-antiTNF-Myeloid-Myeloid_granulocytic-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NLRP12 SLC8B1 SMC1B

3.78e-0414344365328a0a2f3972fac596e07933e74b2ef7cceb84
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.18e-04148443d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.18e-04148443c8e93b87212f55774223caa385859c566fa1981f
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.44e-0415144381cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.44e-041514439cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.70e-041544437556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.70e-041544434e3bc24043144143842627cacf6f90dda2228910
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.79e-041554435f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 DNAH5 AK7

4.79e-041554430944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SMARCA5 PRIMPOL HNRNPR

4.88e-041564435df19a235843829f5a1a90ca21b0964ef8b4e115
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UGGT2 HDAC10 SACS

4.88e-04156443a5930b455e5c8586c43c50106ab4d8a1e5e9e3d6
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SMARCA5 PRIMPOL HNRNPR

4.88e-04156443029ba0832ee9c4a2c85620e4df2260e02d86b45c
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B DNAH10 DNAH5

5.06e-04158443f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B DNAH10 DNAH5

5.06e-041584438c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ADGRV1 DNAH5

5.45e-041624435c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B SIGLEC5 NLRP12

5.74e-04165443af59a095ecc6758abc13d763c00e44447c488167
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTK2B ADNP SACS

5.74e-04165443cced77f2d74b07010307d7f4788b8cf3fdaeb91a
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B SIGLEC5 NLRP12

5.74e-0416544384eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTK2B ADNP SACS

5.74e-041654430c80abf13409767825ef8a507b498afafa7e89c5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ADGRV1 DNAH5

5.85e-04166443c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SIGLEC14 NLRP12 SACS

5.95e-041674431bd0aa7a3c8649f342bb856cf861c4c5984ad889
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH10 DNAH5 AK7

6.05e-04168443fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH10 DNAH5 AK7

6.05e-041684437edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell15-Distal-Epithelial-Multiciliated_cell|Distal / Age, Tissue, Lineage and Cell class

DNAH10 DNAH5 AK7

6.16e-04169443425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 DNAH10 DNAH5

6.16e-0416944312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellhealthy_donor-Myeloid-Monocytic-Developing_Neutrophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

UGGT2 POLQ DNAH10

6.26e-04170443cfd7f29805b7c51666b0eaf269c36c96b8765a1a
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAB3GAP1 ZNF654 APOBEC2

6.26e-04170443070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SIGLEC14 SIGLEC5 NLRP12

6.48e-04172443cf46810dd1072b6f2171e5d9530351ddc79a055b
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Deuterosomal|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH5 AK7

6.48e-0417244308ad76412c9cc3504141797b44b88478ced87476
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UNC13B APOBEC2 PRIMPOL

6.59e-0417344303b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UNC13B APOBEC2 PRIMPOL

6.59e-0417344312da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCellPND28-Endothelial-Endothelial_lymphatic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UNC13B APOBEC2 PRIMPOL

6.59e-041734432978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCellfacs-Trachea-nan-24m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

6.59e-0417344327ae126c720f20d1fe116abbcd358e4cff8baf6b
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UNC13B APOBEC2 PRIMPOL

6.59e-0417344323d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND07-28-samps / Age Group, Lineage, Cell class and subclass

DNAH10 DNAH5 AK7

6.70e-04174443f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH5 AK7

6.70e-0417444300cf27bc23af1472a507be31fba6245a8fdd901b
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH5 AK7

6.70e-04174443b8d1c556290d188f56aeefc17f03119686945fe7
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

UNC13B SMARCA5 ADGRV1

6.70e-041744432cd6638b361ca05ab83d09ce657194aed97873b7
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

DNAH10 DNAH5 AK7

6.81e-04175443c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH5 AK7

6.81e-04175443c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH5 AK7

6.81e-04175443b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCellfacs-Trachea-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

6.93e-04176443ed788a5969edfd1199828ca5b0dd34e7f29c4d30
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POLQ DNAH10 ZNF654

7.04e-041774438abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 DNAH5 AK7

7.04e-041774433cfde67b93f3986312f5e74e42504214d966e7dc
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 DNAH5 AK7

7.04e-0417744312a52a12a87a31e501ced611f46a90d172ca7e35
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH10 DNAH5 AK7

7.16e-04178443de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 DNAH5 AK7

7.27e-04179443d4efbc34f52136039b96451fd0b0a0ad164197c6
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 DNAH5 AK7

7.27e-041794438a66d197a2f55d763ff7ef0bec89ee96f59c3937
ToppCelldroplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8B1 PIR TSSK1B

7.27e-04179443d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCellfacs-Trachea-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.39e-04180443cf6e9f757afeb342c5023f6e6152a1b4d0d164b4
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)-|368C / Donor, Lineage, Cell class and subclass (all cells)

DNAH10 DNAH5 AK7

7.51e-041814435a4574f1bfd0b4ca78da7effda43420857e17296
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)|368C / Donor, Lineage, Cell class and subclass (all cells)

DNAH10 DNAH5 AK7

7.51e-04181443a4e891603645f694687e68e585744ddc1a3c8697
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Ciliated|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAH5 AK7

7.51e-041814438eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH10 DNAH5 AK7

7.51e-04181443dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH10 DNAH5 AK7

7.63e-04182443fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTK2B SIGLEC5 NLRP12

7.63e-04182443243c783675df495ea4112dbf710712c44ea6b4f1
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTK2B SIGLEC5 NLRP12

7.63e-0418244318790a394dc32b3cef99cdbf826392c520e38b4a
ToppCelldroplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.75e-041834433991830726d05cf19606d540de04093985b7bdeb
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAH10 DNAH5 AK7

7.75e-04183443b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAH10 DNAH5 AK7

7.75e-04183443cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.75e-04183443cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 DNAH10 DNAH5

7.88e-04184443ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UGGT2 POLQ DNAH10

7.88e-04184443a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

UGGT2 POLQ DNAH10

7.88e-04184443081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellControl-Myeloid_G-immature_Neutrophil|Control / Disease group, lineage and cell class

UGGT2 POLQ DNAH10

7.88e-0418444345f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 DNAH10 DNAH5

7.88e-041844432cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRV1 DNAH10 DNAH5

7.88e-041844432b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

HM13 MFSD10 PRIMPOL

7.88e-04184443af6522586d012e91241f3e06c60f9d1881e95646
ToppCellfacs-Lung-EPCAM-24m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.88e-04184443afb11ab301ef9801333dbb53ccff4bd0d44f1677
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

UGGT2 POLQ DNAH10

7.88e-0418444384c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCellControl-immature_Neutrophil-|Control / Disease condition and Cell class

UGGT2 POLQ DNAH10

7.88e-04184443c4e8ba82a6aa76c46f05a71d5f1c7926555318cf
ToppCellControl-immature_Neutrophil|Control / Disease condition and Cell class

UGGT2 POLQ DNAH10

7.88e-041844432fdae5c6b3eb2232881d933a8c1061fda3623016
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.88e-04184443d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellP07-Epithelial-airway_epithelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH10 DNAH5 AK7

7.88e-04184443a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCellP07-Epithelial-airway_epithelial_cell-club_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH10 DNAH5 AK7

7.88e-04184443ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.88e-0418444322010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.88e-04184443264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 DNAH5 AK7

7.88e-04184443a411c0bcb283534a1c15f22473c46b7d87e01294
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

UGGT2 POLQ DNAH10

7.88e-04184443d31d4116d1d196633784863781fa45673607a421
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

UNC13B ADGRV1 DNAH5

8.00e-04185443673f0c688ae6984bc8027df2da335787924f4137
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GEMIN4 PTK2B ADNP

8.00e-04185443a2cae8c657e4f4d121476798e424876f7e247973
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH10 DNAH5 AK7

8.00e-041854433e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH10 DNAH5 AK7

8.00e-0418544318a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellwk_15-18-Hematologic-Myeloid-Myelocyte-like|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SIGLEC14 SIGLEC5 NLRP12

8.00e-0418544392b9ec18ff7c53a52b87e2c2012d0b719a7ad20a
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GEMIN4 PTK2B ADNP

8.00e-04185443d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

UNC13B ADGRV1 DNAH5

8.00e-04185443cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH5 AK7

8.00e-041854435e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

DNAH10 DNAH5 AK7

8.00e-041854430998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellP28-Epithelial-airway_epithelial_cell-club_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH10 DNAH5 AK7

8.13e-04186443a26811481668fa25c48a064a56c198685693ad8d
ToppCellP28-Epithelial-airway_epithelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH10 DNAH5 AK7

8.13e-04186443df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ADGRV1 DNAH5

8.13e-041864432ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAH5 AK7

8.13e-0418644376033438426d8f9c72cd6691a7baf92104c9f03d
DrugNSC-14083

GEMIN4 PIR PRPF8 SACS MFSD10 HNRNPR

3.02e-06210446CID000005297
DrugDikar

SMARCA1 SMARCA5

2.18e-054442CID006433517
DrugAC1MIXXG

SMARCA1 NFYC SMARCA5

2.91e-0531443CID003081982
DrugTRIBIZ

SMARCA1 NLRP12 DYNC1H1

3.53e-0533443CID000449279
Drugcupric acetate monohydrate

DNAH5 DYNC1H1

3.64e-055442CID000165397
Diseasecaspase-3 measurement

NLRP12 PRIMPOL

1.07e-054402EFO_0008070
Diseasedolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement

SIGLEC14 SIGLEC5

8.01e-0510402EFO_0801544
Diseasesialic acid-binding Ig-like lectin 14 measurement

SIGLEC14 SIGLEC5

1.17e-0412402EFO_0008284
Diseasecentral nervous system disease (implicated_via_orthology)

SMARCA1 SMARCA5

2.12e-0416402DOID:331 (implicated_via_orthology)
Diseaseresponse to norepinephrine-dopamine reuptake inhibitor

ADGRV1 AK7

5.70e-0426402EFO_0007870
Diseaseserine measurement

OGDH DYNC1H1

1.04e-0335402EFO_0009774
Diseaseresponse to radiation, prostate carcinoma, erectile dysfunction

TDRD15 RMDN2

1.16e-0337402EFO_0001663, EFO_0004234, GO_0009314

Protein segments in the cluster

PeptideGeneStartEntry
FFEEKPEEPVVLALD

ADNP

741

Q9H2P0
EPEVDFVPIIGFLIL

ADGRV1

2881

Q8WXG9
DPEKLKELIELPPFE

APOBEC2

26

Q9Y235
KPLLFEIPGFLTDEE

P4HTM

141

Q9NXG6
LLFLFPDAVSEKPLD

RAB3GAP1

411

Q15042
ENLEFFELAKLLPLP

NPAS1

61

Q99742
LFIFCFLPETLPLEK

MFSD10

216

Q14728
VSLPEDLLEDPEIFF

NFRKB

36

Q6P4R8
EFHLEFLDLVKPEPV

HACD3

56

Q9P035
EIKFDTEIQAFLLPP

IFNAR1

321

P17181
LEPPLFLKIVELFKE

HERC4

551

Q5GLZ8
PELKNLDPFLLFDEF

PIR

31

O00625
KIPRDLYEDELVPLF

HNRNPR

171

O43390
FEAPIKLVFPQDLLE

HM13

236

Q8TCT9
FDFLIDIVPRDELKP

NFYC

111

Q13952
EQLSPFPFDLLLKEV

OGDH

931

Q02218
LLPLAFEFDPELVLV

HDAC10

246

Q969S8
DDIAEVLFLELKLPP

POLQ

2131

O75417
VPKLVAEDIPLLFSL

DYNC1H1

2146

Q14204
PPLKEFFVDDFEELL

DIP2A

286

Q14689
FELLEKEVGLDLFFP

PTK2B

201

Q14289
LPKFVFEDVPLFLGL

DNAH10

2041

Q8IVF4
GELFDPDIEVLKDLF

SACS

1051

Q9NZJ4
EDEPLFLSLIEDLFP

DNAH5

2196

Q8TE73
FPLPAEVCLLFLFKE

PRIMPOL

461

Q96LW4
DIPLPEELIFIVDEK

CROT

361

Q9UKG9
LLIAKEEGLPVPELF

CROT

511

Q9UKG9
FLLLLTVPVVDPDKD

SLC8B1

336

Q6J4K2
ELIPIEDFITPLKFL

MRPL40

81

Q9NQ50
FFPPRLFELLEKEIL

SMARCA1

791

P28370
PFIPVEVLVDLFLKE

PRAME

171

P78395
FFDVKILLPEFCELP

TDRD15

576

B5MCY1
ALIEKPDIHFLEPLE

SIGLEC5

141

O15389
HLDIAIKLLPEEPFL

RMDN2

291

Q96LZ7
EEFELPEFVEPFLKD

PRPF8

376

Q6P2Q9
EPETFLALDYLDIKP

SMC1B

566

Q8NDV3
ELLPILKKGLFFDPE

ZNF654

436

Q8IZM8
ILLDTRFELPFDIPE

UNC13B

121

O14795
DFLEKFLPREIEILA

TSSK1B

51

Q9BXA7
VAKFLDIPESPLLIL

UGGT2

1036

Q9NYU1
FFPPRLFELLEKEIL

SMARCA5

776

O60264
ALIEKPDIHFLEPLE

SIGLEC14

141

Q08ET2
PVAALLEPDEVLKEF

GEMIN4

641

P57678
LEPDEVLKEFVLPFL

GEMIN4

646

P57678
PFDKLIIPEFVCALD

AK7

511

Q96M32
PERLLFIIDGFDELK

NLRP12

286

P59046