Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium:sodium antiporter activity	SLC8A2 SLC8A3 SLC24A3	1.15e-05	10	93	3	GO:0005432
GeneOntologyMolecularFunction	high-affinity IgG receptor activity	FCGR1A FCGR1BP	2.15e-05	2	93	2	GO:0019771
GeneOntologyMolecularFunction	leukotriene receptor binding	FCGR1A FCGR1BP	2.15e-05	2	93	2	GO:0031774
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity	SLC8A2 SLC8A3 SLC24A3	2.70e-05	13	93	3	GO:0015368
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	SLC8A2 SLC8A3	6.42e-05	3	93	2	GO:1905060
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST3 NDST4	1.28e-04	4	93	2	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST3 NDST4	1.28e-04	4	93	2	GO:0050119
GeneOntologyMolecularFunction	protein-hormone receptor activity	INSR GNRHR ADIPOR2	1.41e-04	22	93	3	GO:0016500
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R9 TAS2R40 TAS2R20	2.64e-04	27	93	3	GO:0033038
GeneOntologyMolecularFunction	IgG receptor activity	FCGR1A FCGR1BP	4.44e-04	7	93	2	GO:0019770
GeneOntologyMolecularFunction	taste receptor activity	TAS2R9 TAS2R40 TAS2R20	4.82e-04	33	93	3	GO:0008527
GeneOntologyMolecularFunction	immunoglobulin binding	FCGR1A FCGR1BP JCHAIN	6.25e-04	36	93	3	GO:0019865
GeneOntologyMolecularFunction	deacetylase activity	NDST3 ATXN3L NDST4	8.53e-04	40	93	3	GO:0019213
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC8A2 SLC8A3 SLC24A3	1.05e-03	43	93	3	GO:0140828
GeneOntologyMolecularFunction	IgG binding	FCGR1A FCGR1BP	1.15e-03	11	93	2	GO:0019864
GeneOntologyMolecularFunction	semaphorin receptor activity	PLXNA3 PLXNA2	1.37e-03	12	93	2	GO:0017154
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR1A FCGR1BP	1.88e-03	14	93	2	GO:0019763
GeneOntologyMolecularFunction	sulfotransferase activity	NDST3 NDST4 DSEL	2.15e-03	55	93	3	GO:0008146
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST3 NDST4	2.17e-03	15	93	2	GO:0034483
GeneOntologyBiologicalProcess	memory	LRRC66 VLDLR SLC8A2 SLC8A3 INSR SORCS3 LARGE1	1.67e-05	183	91	7	GO:0007613
Domain	NaCa_Exmemb	SLC8A2 SLC8A3 SLC24A3	8.61e-06	9	89	3	IPR004837
Domain	Na_Ca_ex	SLC8A2 SLC8A3 SLC24A3	8.61e-06	9	89	3	PF01699
Domain	ATPase_V1-cplx_csu	ATP6V1C1 ATP6V1C2	2.25e-05	2	89	2	IPR004907
Domain	V-ATPase_C	ATP6V1C1 ATP6V1C2	2.25e-05	2	89	2	PF03223
Domain	-	PLXNA3 NWD2 WDR36 EML5 POC1A WDSUB1 PLXNA2 RIC1 WDR72	2.97e-05	333	89	9	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PLXNA3 NWD2 WDR36 EML5 POC1A WDSUB1 PLXNA2 RIC1 WDR72	3.11e-05	335	89	9	IPR015943
Domain	Na_Ca_Ex	SLC8A2 SLC8A3	6.72e-05	3	89	2	IPR004836
Domain	Na_Ca_Ex_C-exten	SLC8A2 SLC8A3	6.72e-05	3	89	2	IPR032452
Domain	Na_Ca_ex_C	SLC8A2 SLC8A3	6.72e-05	3	89	2	PF16494
Domain	Quinoprotein_ADH-like_supfam	WDR36 EML5 WDSUB1 WDR72	1.18e-04	53	89	4	IPR011047
Domain	WD40_repeat_CS	NWD2 WDR36 EML5 POC1A WDSUB1 WDR72	1.33e-04	164	89	6	IPR019775
Domain	HSNSD	NDST3 NDST4	1.34e-04	4	89	2	PF12062
Domain	Heparan_SO4_deacetylase	NDST3 NDST4	1.34e-04	4	89	2	IPR021930
Domain	TAS2R	TAS2R9 TAS2R40 TAS2R20	2.51e-04	26	89	3	PF05296
Domain	T2R	TAS2R9 TAS2R40 TAS2R20	2.51e-04	26	89	3	IPR007960
Domain	WD_REPEATS_1	NWD2 WDR36 EML5 POC1A WDSUB1 RIC1 WDR72	3.65e-04	278	89	7	PS00678
Domain	WD_REPEATS_2	NWD2 WDR36 EML5 POC1A WDSUB1 RIC1 WDR72	3.73e-04	279	89	7	PS50082
Domain	WD_REPEATS_REGION	NWD2 WDR36 EML5 POC1A WDSUB1 RIC1 WDR72	3.73e-04	279	89	7	PS50294
Domain	ZF_UBR	UBR5 UBR3	4.64e-04	7	89	2	PS51157
Domain	zf-UBR	UBR5 UBR3	4.64e-04	7	89	2	PF02207
Domain	Znf_UBR	UBR5 UBR3	4.64e-04	7	89	2	IPR003126
Domain	ZnF_UBR1	UBR5 UBR3	4.64e-04	7	89	2	SM00396
Domain	WD40_repeat_dom	NWD2 WDR36 EML5 POC1A WDSUB1 RIC1 WDR72	5.42e-04	297	89	7	IPR017986
Domain	Calx_beta	SLC8A2 SLC8A3	6.17e-04	8	89	2	SM00237
Domain	Sulfotransferase_dom	NDST3 NDST4 DSEL	6.67e-04	36	89	3	IPR000863
Domain	Sulfotransfer_1	NDST3 NDST4 DSEL	6.67e-04	36	89	3	PF00685
Domain	Calx_beta	SLC8A2 SLC8A3	7.91e-04	9	89	2	IPR003644
Domain	Plexin_cytopl	PLXNA3 PLXNA2	7.91e-04	9	89	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA3 PLXNA2	7.91e-04	9	89	2	IPR013548
Domain	Plexin	PLXNA3 PLXNA2	7.91e-04	9	89	2	IPR031148
Domain	Calx-beta	SLC8A2 SLC8A3	7.91e-04	9	89	2	PF03160
Domain	Oxysterol-bd	OSBPL7 OSBPL9	1.44e-03	12	89	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL7 OSBPL9	1.44e-03	12	89	2	IPR018494
Domain	Oxysterol_BP	OSBPL7 OSBPL9	1.44e-03	12	89	2	PF01237
Domain	OSBP	OSBPL7 OSBPL9	1.44e-03	12	89	2	PS01013
Domain	WD40	NWD2 WDR36 EML5 POC1A WDSUB1 WDR72	1.77e-03	268	89	6	SM00320
Domain	WD40_repeat	NWD2 WDR36 EML5 POC1A WDSUB1 WDR72	1.91e-03	272	89	6	IPR001680
Domain	Apc4_WD40_dom	WDR36 EML5	4.03e-03	20	89	2	IPR024977
Domain	ANAPC4_WD40	WDR36 EML5	4.03e-03	20	89	2	PF12894
Domain	RasGEF_N	RASGEF1C RASGEF1A	4.45e-03	21	89	2	PF00618
Domain	Ras-like_Gua-exchang_fac_N	RASGEF1C RASGEF1A	4.87e-03	22	89	2	IPR000651
Domain	RASGEF_NTER	RASGEF1C RASGEF1A	4.87e-03	22	89	2	PS50212
Domain	RASGEF	RASGEF1C RASGEF1A	6.77e-03	26	89	2	PS00720
Domain	IPT	PLXNA3 PLXNA2	7.29e-03	27	89	2	SM00429
Domain	WD40	WDR36 EML5 POC1A WDSUB1 WDR72	7.96e-03	259	89	5	PF00400
Domain	RASGEF_CAT	RASGEF1C RASGEF1A	8.38e-03	29	89	2	PS50009
Domain	RasGEF	RASGEF1C RASGEF1A	8.96e-03	30	89	2	PF00617
Domain	-	RASGEF1C RASGEF1A	8.96e-03	30	89	2	1.10.840.10
Domain	Ras_GEF_dom	RASGEF1C RASGEF1A	8.96e-03	30	89	2	IPR023578
Domain	RASGEF_cat_dom	RASGEF1C RASGEF1A	8.96e-03	30	89	2	IPR001895
Domain	RasGEF	RASGEF1C RASGEF1A	8.96e-03	30	89	2	SM00147
Pathway	REACTOME_SODIUM_CALCIUM_EXCHANGERS	SLC8A2 SLC8A3 SLC24A3	1.80e-05	11	69	3	M27336
Pathway	REACTOME_SODIUM_CALCIUM_EXCHANGERS	SLC8A2 SLC8A3 SLC24A3	3.10e-05	13	69	3	MM15078
Pathway	REACTOME_METABOLISM_OF_LIPIDS	CYP2J2 PIK3CG MTM1 AGMO HSD17B13 PTDSS1 GPX4 HELZ2 OSBPL7 OSBPL9 GPAT2 ARSG	4.16e-05	620	69	12	MM15193
Pubmed	Sodium/calcium exchanger expression in the mouse and rat olfactory systems.	SLC8A2 SLC8A3 SLC24A3	3.93e-07	6	95	3	17311327
Pubmed	Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.	FCGR1A FCGR1BP	7.38e-06	2	95	2	28814603
Pubmed	Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.	SLC8A2 SLC8A3	7.38e-06	2	95	2	23137542
Pubmed	Features and protective efficacy of human mAbs targeting Mycobacterium tuberculosis arabinomannan.	FCGR1A FCGR1BP	7.38e-06	2	95	2	37733444
Pubmed	Modulating IgG effector function by Fc glycan engineering.	FCGR1A FCGR1BP	7.38e-06	2	95	2	28289219
Pubmed	Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice.	FCGR1A FCGR1BP	7.38e-06	2	95	2	35273604
Pubmed	IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice.	FCGR1A FCGR1BP	7.38e-06	2	95	2	16305642
Pubmed	Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.	FCGR1A FCGR1BP	7.38e-06	2	95	2	9257847
Pubmed	Fcγ receptor I alpha chain (CD64) expression in macrophages is critical for the onset of meningitis by Escherichia coli K1.	FCGR1A FCGR1BP	7.38e-06	2	95	2	21124939
Pubmed	Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.	FCGR1A FCGR1BP	7.38e-06	2	95	2	24430180
Pubmed	Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for temperature-compensated circadian rhythms.	SLC8A2 SLC8A3	7.38e-06	2	95	2	33931447
Pubmed	Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity.	FCGR1A FCGR1BP	7.38e-06	2	95	2	38885133
Pubmed	Novel Fc gamma receptor I family gene products in human mononuclear cells.	FCGR1A FCGR1BP	7.38e-06	2	95	2	1430234
Pubmed	The FcRgamma chain is not essential for induction of experimental allergic encephalomyelitis (EAE) or anti-myelin antibody-mediated exacerbation of EAE.	FCGR1A FCGR1BP	7.38e-06	2	95	2	15835266
Pubmed	Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.	ATP6V1C1 ATP6V1C2	7.38e-06	2	95	2	31901859
Pubmed	Extracellular mutations of non-obese diabetic mouse FcgammaRI modify surface expression and ligand binding.	FCGR1A FCGR1BP	7.38e-06	2	95	2	8663283
Pubmed	The interaction of N-glycans in Fcγ receptor I α-chain with Escherichia coli K1 outer membrane protein A for entry into macrophages: experimental and computational analysis.	FCGR1A FCGR1BP	7.38e-06	2	95	2	25231998
Pubmed	Lentivirus-mediated knockdown of FcγRI (CD64) attenuated lupus nephritis via inhibition of NF-κB regulating NLRP3 inflammasome activation in MRL/lpr mice.	FCGR1A FCGR1BP	7.38e-06	2	95	2	30190171
Pubmed	Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.	SLC8A2 SLC8A3	7.38e-06	2	95	2	19667209
Pubmed	Molecular cloning and expression of the mouse high affinity Fc receptor for IgG.	FCGR1A FCGR1BP	7.38e-06	2	95	2	2136886
Pubmed	Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene.	FCGR1A FCGR1BP	7.38e-06	2	95	2	1830050
Pubmed	FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.	FCGR1A FCGR1BP	7.38e-06	2	95	2	30552619
Pubmed	Sensory Neuron Expressed FcγRI Mediates Postinflammatory Arthritis Pain in Female Mice.	FCGR1A FCGR1BP	7.38e-06	2	95	2	35833115
Pubmed	Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.	FCGR1A FCGR1BP	7.38e-06	2	95	2	15528358
Pubmed	GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.	GPR89B GPR89A	7.38e-06	2	95	2	22572823
Pubmed	Functional characteristics of the high affinity IgG receptor, FcγRI.	FCGR1A FCGR1BP	7.38e-06	2	95	2	21325219
Pubmed	Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis.	FCGR1A FCGR1BP	7.38e-06	2	95	2	14991835
Pubmed	Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.	FCGR1A FCGR1BP	7.38e-06	2	95	2	1402657
Pubmed	FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.	FCGR1A FCGR1BP	7.38e-06	2	95	2	8611682
Pubmed	Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.	FCGR1A FCGR1BP	7.38e-06	2	95	2	16409296
Pubmed	Mouse FcgammaRI: identification and functional characterization of five new alleles.	FCGR1A FCGR1BP	7.38e-06	2	95	2	10752630
Pubmed	Fcγ Receptor Type I (CD64)-Mediated Impairment of the Capacity of Dendritic Cells to Activate Specific CD8 T Cells by IgG-opsonized Friend Virus.	FCGR1A FCGR1BP	7.38e-06	2	95	2	30744065
Pubmed	Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.	FCGR1A FCGR1BP	7.38e-06	2	95	2	17124586
Pubmed	Neuronal FcγRI mediates acute and chronic joint pain.	FCGR1A FCGR1BP	7.38e-06	2	95	2	31211699
Pubmed	Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.	FCGR1A FCGR1BP	7.38e-06	2	95	2	8480181
Pubmed	Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.	FCGR1A FCGR1BP	7.38e-06	2	95	2	29576375
Pubmed	Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.	FCGR1A FCGR1BP	7.38e-06	2	95	2	18245810
Pubmed	Reconstitution of allogeneic hemopoietic stem cells: the essential role of FcR gamma and the TCR beta-chain-FCp33 complex.	FCGR1A FCGR1BP	7.38e-06	2	95	2	16849450
Pubmed	Biochemical characterization of murine Fc gamma RI.	FCGR1A FCGR1BP	7.38e-06	2	95	2	8478020
Pubmed	FcγR-binding affinity of monoclonal murine IgG1s carrying different N-linked Fc oligosaccharides.	FCGR1A FCGR1BP	7.38e-06	2	95	2	31554601
Pubmed	GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.	GPR89B GPR89A	7.38e-06	2	95	2	18794847
Pubmed	The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.	SLC8A2 SLC8A3	7.38e-06	2	95	2	23224884
Pubmed	CD64 plays a key role in diabetic wound healing.	FCGR1A FCGR1BP	7.38e-06	2	95	2	38524127
Pubmed	Developmentally ordered appearance of a functional Fc gamma receptor on TCR V gamma 3 thymocytes. Evidence for stimulation-induced expression.	FCGR1A FCGR1BP	7.38e-06	2	95	2	8077658
Pubmed	The involvement of FcR mechanisms in antibody-mediated rejection.	FCGR1A FCGR1BP	7.38e-06	2	95	2	18049118
Pubmed	Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.	FCGR1A FCGR1BP	2.21e-05	3	95	2	16841095
Pubmed	Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells.	FCGR1A FCGR1BP	2.21e-05	3	95	2	12427132
Pubmed	Identification of plexin family molecules in mice.	PLXNA3 PLXNA2	2.21e-05	3	95	2	8806646
Pubmed	Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.	SLC8A2 SLC8A3	2.21e-05	3	95	2	29594857
Pubmed	MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I.	FCGR1A FCGR1BP	2.21e-05	3	95	2	22287715
Pubmed	Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice.	FCGR1A FCGR1BP	2.21e-05	3	95	2	23898046
Pubmed	Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.	FCGR1A FCGR1BP	2.21e-05	3	95	2	22003208
Pubmed	Differential expression of plexin-A subfamily members in the mouse nervous system.	PLXNA3 PLXNA2	2.21e-05	3	95	2	11241833
Pubmed	High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.	SLC8A2 SLC8A3	2.21e-05	3	95	2	21382638
Pubmed	Unique monoclonal antibodies define expression of Fc gamma RI on macrophages and mast cell lines and demonstrate heterogeneity among subcutaneous and other dendritic cells.	FCGR1A FCGR1BP	2.21e-05	3	95	2	12594281
Pubmed	Development of proteoglycan-induced arthritis is critically dependent on Fcgamma receptor type III expression.	FCGR1A FCGR1BP	2.21e-05	3	95	2	15880819
Pubmed	A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies.	FCGR1A FCGR1BP	2.21e-05	3	95	2	28924242
Pubmed	Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.	FCGR1A FCGR1BP	2.21e-05	3	95	2	9892619
Pubmed	Residual LCMV antigen in transiently CD4+ T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory.	FCGR1A FCGR1BP	2.21e-05	3	95	2	30636035
Pubmed	Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses.	FCGR1A FCGR1BP	2.21e-05	3	95	2	26056254
Pubmed	The essential role of complement in antibody-mediated resistance to Salmonella.	FCGR1A FCGR1BP	2.21e-05	3	95	2	30179254
Pubmed	The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21.	FCGR1A FCGR1BP	2.21e-05	3	95	2	8697799
Pubmed	Transcriptional and post-transcriptional regulation of IκB-ζ upon engagement of the BCR, TLRs and FcγR.	FCGR1A FCGR1BP	2.21e-05	3	95	2	23728777
Pubmed	Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.	GPR89B GPR89A	2.21e-05	3	95	2	32220963
Pubmed	FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.	FCGR1A FCGR1BP	2.21e-05	3	95	2	22493081
Pubmed	FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways.	FCGR1A FCGR1BP	2.21e-05	3	95	2	16543474
Pubmed	Aberrant Amygdala-Dependent Cued Fear Memory in Na+/Ca2+ Exchanger 1 Heterozygous Mice.	SLC8A2 SLC8A3	2.21e-05	3	95	2	30324228
Pubmed	Escherichia coli K1 induces pterin production for enhanced expression of Fcγ receptor I to invade RAW 264.7 macrophages.	FCGR1A FCGR1BP	2.21e-05	3	95	2	24161960
Pubmed	The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.	SLC8A2 SLC8A3	2.21e-05	3	95	2	34127021
Pubmed	Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.	SLC8A2 SLC8A3	2.21e-05	3	95	2	21858195
Pubmed	Both Fcgamma receptor I and Fcgamma receptor III mediate disease in accelerated nephrotoxic nephritis.	FCGR1A FCGR1BP	2.21e-05	3	95	2	12707052
Pubmed	FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.	FCGR1A FCGR1BP	2.21e-05	3	95	2	19657115
Pubmed	Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection.	FCGR1A FCGR1BP	2.21e-05	3	95	2	33032297
Pubmed	Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms.	SLC8A2 SLC8A3	2.21e-05	3	95	2	23224887
Pubmed	New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.	SLC8A2 SLC8A3	2.21e-05	3	95	2	23224890
Pubmed	Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.	SLC8A2 SLC8A3	2.21e-05	3	95	2	23224882
Pubmed	Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1.	FCGR1A FCGR1BP	2.21e-05	3	95	2	9763663
Pubmed	C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes.	FCGR1A FCGR1BP	2.21e-05	3	95	2	28432146
Pubmed	Three Na+/Ca2+ exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption.	SLC8A2 SLC8A3	2.21e-05	3	95	2	17317768
Pubmed	Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity.	FCGR1A FCGR1BP	2.21e-05	3	95	2	30297432
Pubmed	FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis.	FCGR1A FCGR1BP	2.21e-05	3	95	2	12875993
Pubmed	Receptors for bitter and sweet taste.	TAS2R9 TAS2R40 TAS2R20	4.35e-05	25	95	3	12139982
Pubmed	Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity.	FCGR1A FCGR1BP	4.41e-05	4	95	2	9551950
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST3 NDST4	4.41e-05	4	95	2	22049073
Pubmed	Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.	SLC8A2 SLC8A3	4.41e-05	4	95	2	15557343
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST3 NDST4	4.41e-05	4	95	2	12070138
Pubmed	C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors.	FCGR1A FCGR1BP	4.41e-05	4	95	2	17182593
Pubmed	Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.	FCGR1A FCGR1BP	4.41e-05	4	95	2	16517729
Pubmed	Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal.	FCGR1A FCGR1BP	4.41e-05	4	95	2	29511065
Pubmed	Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.	SLC8A2 SLC8A3	4.41e-05	4	95	2	29274751
Pubmed	Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.	FCGR1A FCGR1BP	4.41e-05	4	95	2	21169548
Pubmed	Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.	FCGR1A FCGR1BP	4.41e-05	4	95	2	15850792
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA3 PLXNA2	4.41e-05	4	95	2	11306810
Pubmed	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility.	FCGR1A FCGR1BP	4.41e-05	4	95	2	31562320
Pubmed	Fc receptor regulation of protective immunity against Chlamydia trachomatis.	FCGR1A FCGR1BP	4.41e-05	4	95	2	11872097
Pubmed	Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice.	FCGR1A FCGR1BP	4.41e-05	4	95	2	10760808
Pubmed	Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.	FCGR1A FCGR1BP	4.41e-05	4	95	2	9490697
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA3 PLXNA2	4.41e-05	4	95	2	25518740
Pubmed	Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo.	FCGR1A FCGR1BP	4.41e-05	4	95	2	16455953
Pubmed	Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.	FCGR1A FCGR1BP	4.41e-05	4	95	2	1379234
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR5 UBR3	2.89e-04	7	68	2	785
GeneFamily	Taste 2 receptors	TAS2R9 TAS2R40 TAS2R20	4.22e-04	39	68	3	1162
GeneFamily	Plexins	PLXNA3 PLXNA2	4.93e-04	9	68	2	683
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL7 OSBPL9	8.98e-04	12	68	2	670
GeneFamily	WD repeat domain containing	WDR36 EML5 POC1A WDSUB1 WDR72	3.05e-03	262	68	5	362
GeneFamily	V-type ATPases	ATP6V1C1 ATP6V1C2	3.35e-03	23	68	2	415
ToppCell	ASK440-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	CYP2J2 JCHAIN NEURL1 RASGEF1A FAM227B LARGE1	1.44e-06	168	93	6	127559d1a083c68cda9fce143afcc3eec168df17
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Otof_(eccentric_SPN,_iSPN-like_markers)\|Striatum / BrainAtlas - Mouse McCarroll V32	FBXO40 SCN11A TSPEAR GPAT2	6.66e-06	58	93	4	af702c318fc970707660e5d0cfb7b08df3a6e809
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Otof_(eccentric_SPN,_iSPN-like_markers)-\|Striatum / BrainAtlas - Mouse McCarroll V32	FBXO40 SCN11A TSPEAR GPAT2	6.66e-06	58	93	4	538f572db2f34b71058cf09d2db374a906f53580
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TSPEAR GPR87 GOLT1A WDR72	1.26e-05	68	93	4	cfd75c373e10b3761666ccd445ba74755efeb95f
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TSPEAR GPR87 GOLT1A WDR72	1.26e-05	68	93	4	c25fb921dc83eecdc337353894829ae6b5192353
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TSPEAR GPR87 GOLT1A WDR72	1.26e-05	68	93	4	712f5f4d3a1e0c0db1a340332876206b93bdac31
ToppCell	Bronchial_Biopsy-Immune-Neutrophils\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF283 TLR5 RASGEF1A DSEL ABCC6	2.29e-05	162	93	5	985adca17b0c99563feef7910f3da5df31e636b6
ToppCell	PND01-03-samps-Myeloid-Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FCGR1BP PIK3CG DOCK10 B3GNT7 ADIPOR2	2.43e-05	164	93	5	49733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SMIM13 CYP2J2 INSR PACS2 CLDN12	2.73e-05	168	93	5	de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FCGR1BP PIK3CG DOCK10 LONRF3 ADIPOR2	2.80e-05	169	93	5	305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POC1A TLR5 DOCK10 B3GNT7 ADIPOR2	2.97e-05	171	93	5	845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SMIM13 FCGR1A FCGR1BP TRABD TLR5	3.22e-05	174	93	5	eaaf17a06efc09ed4752b449827b1f0f424d3dad
ToppCell	severe_influenza-Plasmablast\|severe_influenza / disease group, cell group and cell class (v2)	EML5 CYP2J2 JCHAIN ATP6V1C2 MCM10	3.22e-05	174	93	5	8c6c4d794373e774ecb3382cb7163b4246b98780
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TLR5 HSD17B13 B3GNT7 TTC6	3.65e-05	89	93	4	a707477b4aad91817ead162474e9a3c92326f60b
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TLR5 HSD17B13 B3GNT7 TTC6	3.65e-05	89	93	4	1d2891e2ab271eae6ded2891208bd2bf37a17500
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TLR5 HSD17B13 B3GNT7 TTC6	3.65e-05	89	93	4	e58b9da18cce5553e18f716c6637fedaaf4858fa
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TLR5 HSD17B13 B3GNT7 TTC6	3.65e-05	89	93	4	4b807b23f0c315c8293a62278d48c67c9be25a1c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CG MAP4K1 JCHAIN CLEC2D DOCK10	3.79e-05	180	93	5	65c069585737302a69b9a01476f4eb8b50cb2bfd
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HELZ2 DOCK10 NDST4 SLC24A3 LONRF3	4.10e-05	183	93	5	6e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 DOCK10 NDST4 SLC24A3 LONRF3	4.32e-05	185	93	5	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 DOCK10 NDST4 SLC24A3 LONRF3	4.32e-05	185	93	5	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_only / Treatment groups by lineage, cell group, cell type	VLDLR MAP4K1 NEURL1 DOCK10 CCDC178	5.96e-05	198	93	5	d205dfcfe1f20e1e21bf84759e723d9e6e610a5c
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells-mDC\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PIK3CG MAP4K1 TRABD GPX4 DOCK10	5.96e-05	198	93	5	e8002972410e4803d85263ba2642e6855cef83e9
Disease	colorectal cancer, hormone replacement therapy	INSR TLR5 SLC24A3 GALNT16	1.69e-04	88	92	4	EFO_0003961, MONDO_0005575
Disease	gastric adenocarcinoma (is_implicated_in)	UBR5 XPO1	5.19e-04	11	92	2	DOID:3717 (is_implicated_in)
Disease	sweet liking measurement	AGMO PNLIPRP3	1.42e-03	18	92	2	EFO_0010156
Disease	glucuronate measurement	PTDSS1 WDR72	1.42e-03	18	92	2	EFO_0010486
Disease	Colorectal Carcinoma	NDST3 NEURL1 GPX4 TSPEAR ARFGEF1 GPR87 DSEL ABCC6	1.59e-03	702	92	8	C0009402
Disease	goiter	INSR FAM227B	2.33e-03	23	92	2	EFO_0004283
Disease	childhood trauma measurement	NDST3 SORCS3	2.54e-03	24	92	2	EFO_0007979
Disease	stomach carcinoma (is_marker_for)	ATP6V1C1 XPO1	2.54e-03	24	92	2	DOID:5517 (is_marker_for)
Disease	response to antiviral drug, cirrhosis of liver	NDST4 PLXNA2	2.54e-03	24	92	2	EFO_0001422, EFO_0010123
Disease	pallidum volume	ARSG WDR72	2.75e-03	25	92	2	EFO_0006933
Disease	Impaired glucose tolerance	INSR GPX4	2.75e-03	25	92	2	C0271650

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDERVFKIWKTHFLS	FAM227B	181	Q96M60
FKIWKTHFLSEASIA	FAM227B	186	Q96M60
TLFSNWKKLKLFVSH	CYP2J2	246	P51589
VSAAFAVKLFKSWIN	BZW1	181	Q7L1Q6
IKVQFHHLFSIWTTF	AGMO	271	Q6ZNB7
IRSGWKNIFSVFHLA	ARFGEF1	1271	Q9Y6D6
KVDHTVKENTFLWFT	ARSG	286	Q96EG1
FKVSIKFVSRVSWHL	AGO3	121	Q9H9G7
KQLRAGFFEHLEKWF	CCDC180	876	Q9P1Z9
FEVNILGHFWITKAL	HSD17B13	141	Q7Z5P4
FAHKLLQLSGVSLFW	ATG2B	216	Q96BY7
IFVIDKSWFNHLGKY	GALNT16	296	Q8N428
HKWNFSSGFIEAVFK	NWD2	1341	Q9ULI1
LFGNNLNFWLHKLIF	NDST3	271	O95803
LNFWLHKLIFIDAIS	NDST3	276	O95803
FKSIFRIHTETGNIW	ADIPOR2	136	Q86V24
NFVIALKRLHKDFLW	RIC1	1106	Q4ADV7
NWHQEFTRFVPKFKV	INO80	581	Q9ULG1
KIQFNAHIWTKSKFL	OSBPL9	516	Q96SU4
GKAFKFFHWNSNLTI	FCGR1BP	141	Q92637
TVKVWATHRQKFLFS	POC1A	126	Q8NBT0
IAELWAVFHKFKGQQ	LARGE1	251	O95461
GNITSVQFIWKKHLF	PNLIPRP3	411	Q17RR3
IKRHSFFSTIDWNKL	RPS6KA3	321	P51812
QLFNFLIIHSWARKV	DDX60	156	Q8IY21
TLWQEHFKLVVLFSQ	CCDC178	806	Q5BJE1
SNALKFWGLEIIHFN	ATXN3L	81	Q9H3M9
FTIRKFGKHWFNLNS	ATXN3L	121	Q9H3M9
KMLTNWFAFLLHKFL	PLXNA2	1436	O75051
LTNWFTFLLHKFLKE	PLXNA3	1416	P51805
HKIFVQGIIWDINSF	GPI	496	P06744
SLFLFGEVHKALWKT	MCM10	331	Q7L590
WSKHNLTITQGKLFF	INSR	441	P06213
FGNNLNFWLHKLIFI	NDST4	271	Q9H3R1
NFWLHKLIFIDAISF	NDST4	276	Q9H3R1
VKFFQLAAQWSSHVK	PACS2	861	Q86VP3
GLRKTFWFFFQRHKL	GOLT1A	51	Q6ZVE7
GLAVWIFFHIRNKTS	GPR87	61	Q9BY21
SVFVTVFGVHLNKWQ	SLC24A3	591	Q9HC58
FFRVLLQSHTKKEEW	LRRC66	71	Q68CR7
STLVHKFFLVFSKWE	PAPOLA	266	P51003
TQHVKVWISFAQFEL	CRNKL1	706	Q9BZJ0
VLKHSWFFFAIILKS	DOCK10	986	Q96BY6
TFNASFLLKLQKWTQ	GNRHR	51	P30968
VKFWSQHISFILVGI	GPR89A	336	B7ZAQ6
VKFWSQHISFILVGI	GPR89B	336	P0CG08
LFKHQKLLGEFSWLT	GPAT2	471	Q6NUI2
HREIWQFSSLFSKIK	FBXO40	636	Q9UH90
GKAFKFFHWNSNLTI	FCGR1A	141	P12314
LFWGVLAVFIKAVHV	JCHAIN	6	P01591
DTQFVSVGVKHVKFW	EML5	1526	Q05BV3
SIWVIFYNIHLNKKF	CLDN12	151	P56749
ILGNAIKWNFTKFLI	GPX4	156	P36969
TIVGLHIVFWFHKSN	HELZ2	2181	Q9BYK8
TFFNLTLKEIHFLKW	B3GNT7	211	Q8NFL0
AFLEFDSIIQKVKWH	SEC22C	111	Q9BRL7
LEFKWLHNNRELTKF	SDK2	56	Q58EX2
SGSWTLKLHFFQEVL	DSEL	1006	Q8IZU8
LKEFIFLHGKKWAAS	NYNRIN	1726	Q9P2P1
HLKIKSQDLFQSWVA	OSBPL7	121	Q9BZF2
GKWSAAFHNFIKVTL	MAP4K1	241	Q92918
SFILIWGNKTLKQTF	TAS2R20	276	P59543
LFKVITVFLNHSNLW	TAS2R40	96	P59535
NFSEAFIAWIHVKAL	ATP6V1C1	286	P21283
NFSEAFIAWIHIKAL	ATP6V1C2	331	Q8NEY4
AVFAWFQEIHAKNIL	TIGD6	81	Q17RP2
KAIWQVFHSTFLLGT	ABCC6	301	O95255
VFGHFSLRSEWQLVK	SORCS3	671	Q9UPU3
WHLFLSKFKFLRELV	SMIM13	31	P0DJ93
KEHSIKATLIWRLFF	CLEC2D	26	Q9UHP7
LTLGHEQFRLKWVSF	CLEC20A	381	Q6ZU45
KAFQKFLSQWKISHT	ERVK-25	716	P63136
TVQFNWFLHLVLGIK	PIK3CG	1081	P48736
RAHWKFLKTVVNKLF	XPO1	556	O14980
FKLVLDSIIWAFKHT	XPO1	871	O14980
KFQKAWNHFTIAIDT	TTC6	296	Q86TZ1
NFKKFWEISRQIHEF	RASGEF1A	406	Q8N9B8
LVQKEWISFGHKFAS	MTM1	406	Q13496
NIIAFWVDKKGRVFH	NEURL1	166	O76050
IANISHPFFFWLKLK	TAS2R9	111	Q9NYW1
TFKRAIAALSFWQKV	TRABD	196	Q9H4I3
TWAKVRTAKFFILEH	RASGEF1C	316	Q8N431
KTKWSNVGFHILLFD	WDR72	671	Q3MJ13
WFHGFITRKQTEQLL	SH2D7	51	A6NKC9
LKHKSFLEELLFWTI	UBR3	376	Q6ZT12
QIVKHSWFESFIIFV	SCN11A	1051	Q9UI33
QAQAWRHFTIGKKIF	TSPEAR	371	Q8WU66
KAFQKFLSQWKISHT	ERVK-19	721	Q9WJR5
IWIVSFTHILGFELK	WDSUB1	216	Q8N9V3
SKDFTWVQNALLKHL	TLR5	701	O60602
KAFFWKSQLITHQRT	ZNF605	316	Q86T29
IWQLTELNTFFLKHI	PTDSS1	296	P48651
KAFNWFATLTNHKRI	ZNF680	301	Q8NEM1
KVLLGRKVNWHDFAF	UBR5	2556	O95071
KAFFWGSSLAKHEII	ZNF283	326	Q8N7M2
GLLKFWNFKNKILIH	WDR36	561	Q8NI36
WNFKNKILIHSVSLS	WDR36	566	Q8NI36
QKLFWADLSQKAIFS	VLDLR	481	P98155
QQASLWFHSLKLSLK	LONRF3	676	Q496Y0
KIKHLRVFFVTASWS	SLC8A2	191	Q9UPR5
KIKHLRVFFITAAWS	SLC8A3	196	P57103