Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	poly(A) binding	PABPC3 PABPC4 PABPC1L PABPC1	4.06e-06	29	75	4	GO:0008143
GeneOntologyMolecularFunction	poly(U) RNA binding	PABPC3 PABPC4 PABPC1L PABPC1	7.82e-06	34	75	4	GO:0008266
GeneOntologyMolecularFunction	poly-purine tract binding	PABPC3 PABPC4 PABPC1L PABPC1	1.10e-05	37	75	4	GO:0070717
GeneOntologyMolecularFunction	poly-pyrimidine tract binding	PABPC3 PABPC4 PABPC1L PABPC1	1.37e-05	39	75	4	GO:0008187
GeneOntologyMolecularFunction	5-methylcytosine dioxygenase activity	TET2 TET1	4.17e-05	3	75	2	GO:0070579
GeneOntologyMolecularFunction	MutLalpha complex binding	MSH6 ATR	2.89e-04	7	75	2	GO:0032405
GeneOntologyMolecularFunction	zinc ion binding	TET2 AGBL4 ZZZ3 ZFHX4 ENPP2 TET1 NSD1 ZNF84 ADAMTS5 ZZEF1 NR1I3	4.71e-04	891	75	11	GO:0008270
GeneOntologyMolecularFunction	mismatch repair complex binding	MSH6 ATR	7.49e-04	11	75	2	GO:0032404
GeneOntologyMolecularFunction	single-stranded RNA binding	PABPC3 PABPC4 PABPC1L PABPC1	8.11e-04	111	75	4	GO:0003727
GeneOntologyMolecularFunction	STAT family protein binding	PARP9 HSF1	1.06e-03	13	75	2	GO:0097677
GeneOntologyCellularComponent	mCRD-mediated mRNA stability complex	PABPC3 PABPC1	1.84e-04	6	74	2	GO:0106002
GeneOntologyCellularComponent	cytoplasmic stress granule	PABPC3 PABPC4 PABPC1L PABPC1	3.76e-04	96	74	4	GO:0010494
MousePheno	abnormal female meiosis	ATR TET1 PABPC1L HSF1 BRWD1	2.70e-05	84	59	5	MP:0005168
Domain	PolyA	PABPC3 PABPC4 PABPC1L PABPC1	1.07e-09	5	73	4	SM00517
Domain	-	PABPC3 PABPC4 PABPC1L PABPC1	1.07e-09	5	73	4	1.10.1900.10
Domain	PABP	PABPC3 PABPC4 PABPC1L PABPC1	1.07e-09	5	73	4	PF00658
Domain	PABC	PABPC3 PABPC4 PABPC1L PABPC1	1.07e-09	5	73	4	PS51309
Domain	PABP_1234	PABPC3 PABPC4 PABPC1L PABPC1	1.07e-09	5	73	4	IPR006515
Domain	PABP_HYD	PABPC3 PABPC4 PABPC1L PABPC1	1.07e-09	5	73	4	IPR002004
Domain	RRM_dom_euk	PABPC3 PABPC4 PABPC1L PABPC1	1.80e-06	23	73	4	IPR003954
Domain	RRM_1	PABPC3 PABPC4 PABPC1L PABPC1	1.80e-06	23	73	4	SM00361
Domain	Tet_JBP	TET2 TET1	1.51e-05	2	73	2	PF12851
Domain	2OGFeDO_noxygenase_dom	TET2 TET1	1.51e-05	2	73	2	IPR024779
Domain	Tet_JBP	TET2 TET1	1.51e-05	2	73	2	SM01333
Domain	ZZ	ZZZ3 ZZEF1	2.21e-03	18	73	2	PF00569
Domain	ZF_ZZ_2	ZZZ3 ZZEF1	2.21e-03	18	73	2	PS50135
Domain	ZF_ZZ_1	ZZZ3 ZZEF1	2.21e-03	18	73	2	PS01357
Domain	Znf_ZZ	ZZZ3 ZZEF1	2.47e-03	19	73	2	IPR000433
Domain	ZnF_ZZ	ZZZ3 ZZEF1	2.47e-03	19	73	2	SM00291
Domain	PWWP	MSH6 NSD1	2.74e-03	20	73	2	SM00293
Domain	PWWP	MSH6 NSD1	3.61e-03	23	73	2	PF00855
Domain	PWWP_dom	MSH6 NSD1	3.61e-03	23	73	2	IPR000313
Domain	PWWP	MSH6 NSD1	3.93e-03	24	73	2	PS50812
Domain	WGR_domain	ART1 PARP9	3.93e-03	24	73	2	IPR008893
Pubmed	Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence.	PABPC3 PABPC1L PABPC1	9.63e-09	3	75	3	26134869
Pubmed	Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.	PABPC3 PABPC1L PABPC1	9.63e-09	3	75	3	25034140
Pubmed	Epab is dispensable for mouse spermatogenesis and male fertility.	PABPC3 PABPC1L PABPC1	9.63e-09	3	75	3	24599567
Pubmed	The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.	PABPC3 PABPC1L PABPC1	9.63e-09	3	75	3	26843391
Pubmed	Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.	PABPC3 PABPC4 PABPC1	9.63e-09	3	75	3	21940797
Pubmed	Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries.	PABPC3 PABPC1L PABPC1	9.63e-09	3	75	3	25370180
Pubmed	Epab and Pabpc1 are differentially expressed during male germ cell development.	PABPC3 PABPC1L PABPC1	9.63e-09	3	75	3	22814100
Pubmed	An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.	PABPC3 PABPC1L PABPC1	3.85e-08	4	75	3	15630085
Pubmed	HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.	PABPC3 PABPC4 PABPC1	9.60e-08	5	75	3	19956697
Pubmed	Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.	PABPC3 PABPC1L PABPC1	9.60e-08	5	75	3	26492470
Pubmed	MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty.	PABPC3 PABPC4 PABPC1	9.60e-08	5	75	3	33744966
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MSH6 ZZZ3 WIZ ZFHX4 DNAJA2 SPTLC1 CLSTN2 ASCC3 CSMD1 ZZEF1 IQCM RCOR2 SORL1 BRWD1	1.02e-07	1116	75	14	31753913
Pubmed	The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.	PABPC3 PABPC4 PABPC1	1.92e-07	6	75	3	10358005
Pubmed	Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos.	PABPC3 PABPC1L PABPC1	1.92e-07	6	75	3	30302808
Pubmed	Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes.	PABPC3 PABPC4 PABPC1	3.35e-07	7	75	3	10543404
Pubmed	Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.	PABPC3 PABPC1L PABPC1	5.35e-07	8	75	3	22621333
Pubmed	Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.	PABPC3 PABPC1L PABPC1	8.02e-07	9	75	3	28203794
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 ZZZ3 WIZ ZFHX4 TET1 HUWE1 ASCC3 RCOR2	3.40e-06	418	75	8	34709266
Pubmed	Distributive Processing by the Iron(II)/α-Ketoglutarate-Dependent Catalytic Domains of the TET Enzymes Is Consistent with Epigenetic Roles for Oxidized 5-Methylcytosine Bases.	TET2 TET1	4.59e-06	2	75	2	27362828
Pubmed	Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.	PABPC3 PABPC1	4.59e-06	2	75	2	19020299
Pubmed	Structural insight into substrate preference for TET-mediated oxidation.	TET2 TET1	4.59e-06	2	75	2	26524525
Pubmed	Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.	TET2 TET1	4.59e-06	2	75	2	30045709
Pubmed	Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.	TET2 TET1	4.59e-06	2	75	2	23415914
Pubmed	Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.	TET2 TET1	4.59e-06	2	75	2	30540950
Pubmed	Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation.	TET2 TET1	4.59e-06	2	75	2	32114381
Pubmed	Early Expression of Tet1 and Tet2 in Mouse Zygotes Altered DNA Methylation Status and Affected Embryonic Development.	TET2 TET1	4.59e-06	2	75	2	35955629
Pubmed	Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.	PABPC3 PABPC1	4.59e-06	2	75	2	26971890
Pubmed	Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.	TET2 TET1	4.59e-06	2	75	2	24214992
Pubmed	Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.	TET2 TET1	4.59e-06	2	75	2	24474761
Pubmed	Ten-eleven translocation protein 1 modulates medulloblastoma progression.	TET2 TET1	4.59e-06	2	75	2	33926529
Pubmed	Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming.	TET2 TET1	4.59e-06	2	75	2	24672749
Pubmed	Levels of free PABP are limited by newly polyadenylated mRNA in early Spisula embryogenesis.	PABPC3 PABPC1	4.59e-06	2	75	2	10954604
Pubmed	A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands.	TET2 TET1	4.59e-06	2	75	2	27288448
Pubmed	Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination.	TET2 TET1	4.59e-06	2	75	2	30606231
Pubmed	Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.	TET2 TET1	4.59e-06	2	75	2	34165552
Pubmed	The promoter of the Poly(A) binding protein 2 (Pabp2) retroposon is derived from the 5'-untranslated region of the Pabp1 progenitor gene.	PABPC3 PABPC1	4.59e-06	2	75	2	10534404
Pubmed	Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.	TET2 TET1	4.59e-06	2	75	2	26598602
Pubmed	The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes.	PABPC3 PABPC1	4.59e-06	2	75	2	9732454
Pubmed	Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.	TET2 TET1	4.59e-06	2	75	2	26586431
Pubmed	Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.	TET2 TET1	4.59e-06	2	75	2	35075236
Pubmed	TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.	TET2 CSMD1	4.59e-06	2	75	2	25695618
Pubmed	Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells.	TET2 TET1	4.59e-06	2	75	2	26328763
Pubmed	Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells.	TET2 TET1	4.59e-06	2	75	2	27778125
Pubmed	Nucleotide sequence of a mouse testis poly(A) binding protein cDNA.	PABPC3 PABPC1	4.59e-06	2	75	2	1630930
Pubmed	TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells.	TET2 TET1	4.59e-06	2	75	2	27863519
Pubmed	Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.	TET2 TET1	4.59e-06	2	75	2	28783731
Pubmed	Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells.	TET2 TET1	4.59e-06	2	75	2	28252217
Pubmed	Developmental expression of poly(A) binding protein mRNAs during spermatogenesis in the mouse.	PABPC3 PABPC1	4.59e-06	2	75	2	7893484
Pubmed	A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.	PABPC3 PABPC1 RCOR2	1.25e-05	21	75	3	19345177
Pubmed	Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.	TET2 TET1	1.37e-05	3	75	2	30074219
Pubmed	Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.	TET2 TET1	1.37e-05	3	75	2	24194590
Pubmed	PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.	TET2 TET1	1.37e-05	3	75	2	26325469
Pubmed	TET proteins in malignant hematopoiesis.	TET2 TET1	1.37e-05	3	75	2	19923888
Pubmed	Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.	TET2 TET1	1.37e-05	3	75	2	31433977
Pubmed	Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency.	TET2 TET1	1.37e-05	3	75	2	31844322
Pubmed	Selective targeting of TET catalytic domain promotes somatic cell reprogramming.	TET2 TET1	1.37e-05	3	75	2	32024762
Pubmed	Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.	TET2 TET1	1.37e-05	3	75	2	27184841
Pubmed	Human testis expresses a specific poly(A)-binding protein.	PABPC3 PABPC1	1.37e-05	3	75	2	11328870
Pubmed	Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.	TET2 TET1	1.37e-05	3	75	2	24838012
Pubmed	Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.	TET2 TET1	1.37e-05	3	75	2	21778364
Pubmed	Tet family proteins and 5-hydroxymethylcytosine in development and disease.	TET2 TET1	1.37e-05	3	75	2	22569552
Pubmed	Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins.	TET2 TET1	1.37e-05	3	75	2	26356709
Pubmed	Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.	TET2 TET1	1.37e-05	3	75	2	29662175
Pubmed	A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood-brain barrier.	TET2 TET1	1.37e-05	3	75	2	35235761
Pubmed	One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering.	TET2 TET1	1.37e-05	3	75	2	23992847
Pubmed	Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.	TET2 TET1	1.37e-05	3	75	2	19372391
Pubmed	Inhibition of Tet1- and Tet2-mediated DNA demethylation promotes immunomodulation of periodontal ligament stem cells.	TET2 TET1	1.37e-05	3	75	2	31611558
Pubmed	The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.	TET2 TET1	1.37e-05	3	75	2	25915124
Pubmed	Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.	PABPC3 PABPC1	1.37e-05	3	75	2	29578408
Pubmed	SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport.	PABPC3 PABPC1	1.37e-05	3	75	2	28756945
Pubmed	Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.	TET2 TET1	1.37e-05	3	75	2	25608811
Pubmed	Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.	TET2 TET1	1.37e-05	3	75	2	19420352
Pubmed	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs.	PABPC3 PABPC1	1.37e-05	3	75	2	29701755
Pubmed	Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.	TET2 TET1	1.37e-05	3	75	2	28218476
Pubmed	Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.	TET2 TET1	1.37e-05	3	75	2	23548903
Pubmed	MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL.	TET2 TET1	1.37e-05	3	75	2	31266538
Pubmed	5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.	TET2 TET1	1.37e-05	3	75	2	34919053
Pubmed	Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.	TET2 TET1	1.37e-05	3	75	2	24958354
Pubmed	One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.	TET2 TET1	1.37e-05	3	75	2	23643243
Pubmed	Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.	TET2 TET1	1.37e-05	3	75	2	34879277
Pubmed	Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response.	PABPC3 PABPC1	1.37e-05	3	75	2	28635594
Pubmed	Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.	TET2 TET1	1.37e-05	3	75	2	23352810
Pubmed	Oxygen regulation of TET enzymes.	TET2 TET1	1.37e-05	3	75	2	33410283
Pubmed	Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.	TET2 TET1	1.37e-05	3	75	2	21816367
Pubmed	Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.	TET2 TET1	1.37e-05	3	75	2	22445327
Pubmed	The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs.	PABPC3 PABPC1	1.37e-05	3	75	2	10076007
Pubmed	IGF2BP1 expression in human mesenchymal stem cells significantly affects their proliferation and is under the epigenetic control of TET1/2 demethylases.	TET2 TET1	1.37e-05	3	75	2	24915579
Pubmed	TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.	TET2 TET1	1.37e-05	3	75	2	26711177
Pubmed	miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.	TET2 TET1	1.37e-05	3	75	2	31941838
Pubmed	TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).	TET2 TET1	1.37e-05	3	75	2	12646957
Pubmed	Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.	TET2 TET1	1.37e-05	3	75	2	24735881
Pubmed	PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.	TET2 TET1	1.37e-05	3	75	2	24335252
Pubmed	Differential expression of ten-eleven translocation genes in endometrial cancers.	TET2 TET1	1.37e-05	3	75	2	28349832
Pubmed	Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.	TET2 TET1	1.37e-05	3	75	2	27345836
Pubmed	Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion.	TET2 TET1	1.37e-05	3	75	2	23453809
Pubmed	Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.	TET2 TET1	1.37e-05	3	75	2	20639862
Pubmed	Ten-Eleven Translocation Genes are Downregulated in Endometriosis.	TET2 TET1	1.37e-05	3	75	2	26917261
Pubmed	Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.	PABPC3 PABPC1	1.37e-05	3	75	2	28611064
Pubmed	A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway.	PABPC3 PABPC1	1.37e-05	3	75	2	37665675
Pubmed	Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.	A2M ADAMTS5	1.37e-05	3	75	2	14715656
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	ZZZ3 ZZEF1	1.16e-03	18	51	2	91
GeneFamily	PWWP domain containing	MSH6 NSD1	1.74e-03	22	51	2	1147
GeneFamily	RNA binding motif containing	PABPC3 PABPC4 PABPC1L PABPC1	3.04e-03	213	51	4	725
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	NOD1 CASP9	3.23e-03	30	51	2	959
Coexpression	PGF_UP.V1_UP	ZZZ3 ATR IL1RL1 ASCC3 MAPK6 THOC2	1.65e-05	190	74	6	M2674
Coexpression	GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_4H_CD4_TCELL_UP	SLC9A9 BMX SUSD4 ENPP2 ADAMTS5 BRWD1	1.86e-05	194	74	6	M4187
Coexpression	HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_DN	A2M PABPC4 IL1RL1	3.20e-05	22	74	3	M1191
ToppCell	PND01-03-samps-Mesenchymal-Pericyte-pericyte_E\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SLC9A9 OBSCN CLSTN2 PP2D1 PABPC1	3.29e-06	135	75	5	35928195cf34f055b353562c96f451aef2344d64
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RADIL SUSD4 SLC26A9 CEP152 CLSTN2	5.51e-06	150	75	5	47ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ZFHX4 RGS22 OBSCN CSMD1	1.48e-05	184	75	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ZFHX4 RGS22 OBSCN CSMD1	1.48e-05	184	75	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M ZFHX4 RGS22 OBSCN CSMD1	1.48e-05	184	75	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	A2M MSH6 DOCK8 HUWE1 UTY	1.56e-05	186	75	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	A2M ZZZ3 NSD1 HUWE1 UTY	1.77e-05	191	75	5	9454f642c3621370fa23640b631301346b300950
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M IKZF2 PABPC1L IL1RL1 BRWD1	1.87e-05	193	75	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M DOCK8 DAB2 PABPC1 SORL1	2.11e-05	198	75	5	00a54af5267bfe0eeab6720bf890dc4b6b803bfd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M DOCK8 DAB2 PABPC1 SORL1	2.11e-05	198	75	5	b50074297184bcc044d06e20bb1d3733b9bd8df7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	A2M SLC9A9 GALM DOCK8 PARP9	2.21e-05	200	75	5	4b937b1d0179d1d0e51931f35720e205d460a07e
Drug	Estropipate [7280-37-7]; Up 200; 9.2uM; PC3; HT_HG-U133A	ART1 CEP152 ADAMTS5 HUWE1 ZZEF1 TESK1 CEMIP	3.39e-06	198	73	7	4472_UP
Disease	Seckel syndrome 1	ATR CEP152	1.86e-05	3	74	2	C4551474
Disease	alpha-2-macroglobulin measurement	A2M TET2	1.72e-04	8	74	2	EFO_0020138
Disease	Hepatocellular Adenoma	A2M NR1I3	2.21e-04	9	74	2	C0206669
Disease	health literacy measurement	DAB2 UTP20 CSMD1	3.24e-04	53	74	3	EFO_0010104
Disease	creatinine measurement	TET2 ZZZ3 OBSCN DAB2 NSD1 CASP9 ASCC3 SORL1 CEMIP	8.43e-04	995	74	9	EFO_0004518
Disease	Malignant neoplasm of endometrium	MSH6 ATR	9.25e-04	18	74	2	C0007103
Disease	Carcinoma in situ of endometrium	MSH6 ATR	9.25e-04	18	74	2	C0346191
Disease	FEV/FEC ratio	TET2 AGBL4 KIAA0232 PABPC4 NSD1 SLC26A9 IL1RL1 ADAMTS5 CSMD1 SORL1	9.59e-04	1228	74	10	EFO_0004713
Disease	osteoarthritis (biomarker_via_orthology)	CASP9 ADAMTS5	1.26e-03	21	74	2	DOID:8398 (biomarker_via_orthology)
Disease	Seckel syndrome	ATR CEP152	1.39e-03	22	74	2	C0265202
Disease	diet measurement, fasting blood insulin measurement	CRACR2A CLSTN2	1.39e-03	22	74	2	EFO_0004466, EFO_0008111
Disease	Malignant neoplasm of breast	MSH6 SPTLC1 OBSCN UTP20 ADGRF4 TESK1 PABPC1 FAAH SORL1	1.44e-03	1074	74	9	C0006142
Disease	diet measurement, HOMA-IR	CRACR2A CLSTN2	1.52e-03	23	74	2	EFO_0004501, EFO_0008111
Disease	breast cancer (implicated_via_orthology)	MSH6 ATR	1.79e-03	25	74	2	DOID:1612 (implicated_via_orthology)
Disease	upper respiratory tract disorder	TET2 IL1RL1	2.25e-03	28	74	2	MONDO_0004867
Disease	Neoplasm of uncertain or unknown behavior of ovary	MSH6 ATR	2.41e-03	29	74	2	C0496920

Protein segments in the cluster

Peptide	Gene	Start	Entry
DFFQSGEIGGHCKLD	EOGT	176	Q5NDL2
LEFQFGDGSCKHLNS	CEP152	1441	O94986
FHCDDGFVKTQGSES	CSMD1	721	Q96PZ7
FDLCGGLDGFFAVKH	ADAMTS5	146	Q9UNA0
HSGFFVDGKFLCCQQ	BMX	121	P51813
CAKDFHGEIGFTCNQ	ADGRF4	66	Q8IZF3
QEFFQTCDAEGKGFI	CRACR2A	56	Q9BSW2
FAGEICAFKIHGQEL	CLSTN2	76	Q9H4D0
CNFFDFDTFGGHIKF	CEMIP	516	Q8WUJ3
FCEKFSGQLNSHGCF	A2M	286	P01023
VLFEQAFGFHGKCFQ	RCOR2	141	Q8IZ40
IKNGFLHFENFTCVD	NSD1	146	Q96L73
NFFSDCGHFPTQKQV	IQCM	386	A0A1B0GVH7
VFEAEVLTGFFCQGH	PARP9	761	Q8IXQ6
VCDENGSKGYGFVHF	PABPC1	131	P11940
KGFGFVSFERHEDAQ	PABPC1	231	P11940
FGAAGEHFFQKLSCT	RADIL	686	Q96JH8
YHFNALTCEGCKGFF	NR1I3	21	Q14994
YVCGGEGQHQFFAIK	DAB2	136	P98082
HDIGLNHKSCFNAFF	NDRG3	61	Q9UGV2
VCDENGSKGYAFVHF	PABPC4	131	Q13310
GNSFHVFDQGQFAKE	HSF1	41	Q00613
ENGLNKGFSFIFHED	KIAA0232	1006	Q92628
QFVSGGEDCFFINQF	MAPK6	596	Q16659
GFKDNLHAVFCLAEN	NPEPL1	301	Q8NDH3
NKDHFQFTNLFLCGL	NOD1	581	Q9Y239
NSGHSRCFGFVNFEK	PABPC1L	226	Q4VXU2
GKFFIGQFSDDRHCS	MSH6	566	P52701
FNGEGEQIRAFKCEH	IKZF2	461	Q9UKS7
KFLCSGGHNALFETF	HUWE1	1156	Q7Z6Z7
FTGQKLEVFGDCDNF	CRYGN	16	Q8WXF5
VCDENGSKGYGFVHF	PABPC3	131	Q9H361
KGFGFVSFERHEDAQ	PABPC3	231	Q9H361
LHNVGFADRGFFGCE	OBSCN	2046	Q5VST9
VEALCGFQFTFKHLD	DNAJA2	276	O60884
DFHLNGFDHNFCLKG	GALM	236	Q96C23
VHVDFNCLFNKGETF	ATR	2491	Q13535
AGDYTCKFIHNENGA	IL1RL1	176	Q01638
ENFHCDLNSDQFKGF	DOCK8	301	Q8NF50
LFFIQACGGEQKDHG	CASP9	281	P55211
KGHLIFDACFESGNL	AGBL4	41	Q5VU57
IEGQGHGAVFDCKFS	BRWD1	511	Q9NSI6
HGAVFDCKFSQDGQH	BRWD1	516	Q9NSI6
NQKFLGTHCTFGDDR	HAS1	326	Q92839
DLFFANEKGANFHDV	GLRA2	131	P23416
FSDGGHTFLQNFKGD	FAAH	381	O00519
SGKCFFQGDHGFDNK	ENPP2	466	Q13822
ADGKQKAFFTCFSHL	OR5G3	231	P0C626
CHTFGKNGLEFDTGI	RETSAT	106	Q6NUM9
KEHFGTFFECLQESL	UTP20	286	O75691
GKVESDFFCQLGHFN	UTY	86	O14607
FHKVCDEFGFQCQNG	SORL1	1321	Q92673
AGQLKNGDFHFTDCL	SLC9A9	191	Q8IVB4
NGDFHFTDCLFFGSL	SLC9A9	196	Q8IVB4
ALGCSNFFGSFFKIH	SLC26A9	371	Q7LBE3
VSFDDCFESIHGKNF	RGS22	351	Q8NE09
CHKNSIKFFTGDVFG	SAE1	146	Q9UBE0
FCGEFFENRKGLSSH	WIZ	1231	O95785
FQVHIQGFFCQDGDL	PLPPR1	41	Q8TBJ4
NGKECINFASFNFLG	SPTLC1	96	O15269
IASKFQNFGQFCPHD	TET1	1191	Q8NFU7
EHGDRVFFGKNLAFS	ASCC3	156	Q8N3C0
FYDSQGIHFKFCVEN	SENP5	661	Q96HI0
EDAAVNHQKSFCYFG	ZFHX4	3366	Q86UP3
DQCHDTLVQFGGFLA	THOC2	771	Q8NI27
LCKGHEGSFFSAFLN	TMEM179	96	Q6ZVK1
DQIKNCGFFYGHSAF	SLC35A5	291	Q9BS91
FEGSVARFHCQDGFK	SUSD4	76	Q5VX71
DFHCAEKIGAGFFSE	TESK1	56	Q15569
FCEGGFKIHEADINA	SERINC3	71	Q13530
IKRGHECDAFGKNFN	ZNF84	101	P51523
EECGNGFSLASHFQD	ZNF112	446	Q9UJU3
TCQKDFTNYFGHLEG	ZZEF1	1621	O43149
LTGGEFHFYNFGCKD	VWA3B	651	Q502W6
FGQTKVEECFHGENQ	TET2	776	Q6N021
AESGFVQHVGFKCDN	ZZZ3	811	Q8IYH5
GHSFVCDVNGFSFVK	PPIP5K1	326	Q6PFW1
GNKPNVCFFGLFDGH	PP2D1	196	A8MPX8
KHVAAQQFGEDTFFG	ART1	206	P52961